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1. Ferris RL, Xi L, Raja S, Hunt JL, Wang J, Gooding WE, Kelly L, Ching J, Luketich JD, Godfrey TE: Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neck. Cancer Res; 2005 Mar 15;65(6):2147-56
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  • [Title] Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neck.
  • Clinical staging of cervical lymph nodes from patients with squamous cell carcinoma of the head and neck (SCCHN) has only 50% accuracy compared with definitive pathologic assessment.
  • Consequently, both clinically positive and clinically negative patients frequently undergo neck dissections that may not be necessary.
  • To address this potential overtreatment, sentinel lymph node (SLN) biopsy is currently being evaluated to provide better staging of the neck.
  • We used quantitative reverse transcription-PCR (QRT-PCR) to screen 40 potential markers for their ability to detect SCCHN metastases to cervical lymph nodes.
  • Seven markers were identified with good characteristics for identifying metastatic disease, and these were validated using a set of 26 primary tumors, 19 histologically positive lymph nodes, and 21 benign nodes from patients without cancer.
  • Four markers discriminated between positive and benign nodes with accuracy >97% but only one marker, pemphigus vulgaris antigen (PVA), discriminated with 100% accuracy in both the observed data and a statistical bootstrap analysis.
  • The automated analysis with PVA provided perfect discrimination between histologically positive and benign lymph nodes and correctly identified two lymph nodes with micrometastatic tumor deposits.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Lymph Nodes / pathology. Reverse Transcriptase Polymerase Chain Reaction / methods. Sentinel Lymph Node Biopsy / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 15781625.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA90665-01
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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2. Baghi M, Mack MG, Wagenblast J, Hambek M, Rieger J, Bisdas S, Gstoettner W, Engels K, Vogl T, Knecht R: Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results? Anticancer Res; 2007 Sep-Oct;27(5B):3571-5
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  • [Title] Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results?
  • AIM: To evaluate the accuracy of ultrasmall paramagnetic iron oxide (USPIO: Sinerem)-enhanced MRI in patients with head and neck cancer and enlarged lymph nodes compared with current staging examinations using histology as a gold standard.
  • PATIENTS AND METHODS: Seventeen patients with a histologically proven squamous cell cancer of the head and neck (SCCHN) and different N-stages underwent a non-enhanced and a USPIO-enhanced MRI examination.
  • One patient showed a lymph node of 6 mm in the short axial diameter which was suggested as being metastatic in Sinerem-enhanced MRI according to the enhancement pattern of Sinerem.
  • [MeSH-major] Ferric Compounds / metabolism. Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 17972519.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
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3. Vandecaveye V, De Keyzer F, Hermans R: Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy. Cancer Imaging; 2008;8:173-80
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  • [Title] Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy.
  • In patients with head and neck squamous cell carcinoma (SCC), nodal metastases are an adverse prognostic factor compromising long term patient survival.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) remain the primary imaging modalities for locoregional staging of head and neck SCC.
  • Next to evaluation of the primary tumour, both modalities facilitate detection of non-palpable lymph nodes (LN).
  • However, both modalities rely on size-related and morphological criteria to differentiate between benign and malignant lymph nodes, decreasing the sensitivity for detection of small metastases.
  • The added value of DW-MRI to conventional imaging for staging of lymph nodes in head and neck cancer is discussed, before and after treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Diffusion Magnetic Resonance Imaging / methods. Echo-Planar Imaging / methods. Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Lymphatic Diseases / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Neck / pathology. Neoplasm Staging. Postoperative Care / methods. Preoperative Care / methods. Radiotherapy, Adjuvant. Sensitivity and Specificity. Surgical Procedures, Operative / methods. Survival Rate. Treatment Outcome

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  • (PMID = 18824423.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 27
  • [Other-IDs] NLM/ PMC2556503
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4. Rosário PW, Tavares Júnior WC, Biscolla RP, Purisch S, Maciel RM: [Usefulness of neck ultrasonography in the follow-up of patients with differentiated thyroid cancer]. Arq Bras Endocrinol Metabol; 2007 Jun;51(4):593-600
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  • [Title] [Usefulness of neck ultrasonography in the follow-up of patients with differentiated thyroid cancer].
  • [Transliterated title] Emprego da ultra-sonografia cervical no seguimento de pacientes com carcinoma diferenciado de tireóide.
  • Neck ultrasonography (US) is recommended for the assessment of all patients with thyroid carcinoma after initial therapy, since even low-risk patients with undetectable stimulated thyroglobulin (Tg) may present cervical metastases.
  • Cervical lymph nodes with a diameter > 5 mm presenting thin calcifications and/or cystic degeneration have almost always a malignant etiology.
  • In the absence of these characteristics, a round shape and the absence of an echogenic hilum are "suspicious" findings, whereas elongated lymph nodes with a visible echogenic hilum are considered benign.
  • In the presence of "suspicious" lymph nodes upon US, fine-needle aspiration cytology and measurement of Tg in the needle lavage fluid are useful and complementary exams for the definition of the etiology, with the combination of the two methods showing elevated sensitivity and 100% specificity.
  • US is also useful before thyroidectomy, even contributing in some cases to modify the surgical planning, and before ablation for the measurement of thyroid remnants and detection of persistent lymph node metastases.
  • Another application of this imaging method is to guide the injection of ethanol (sclerotherapy) or the introduction of electrodes for radiofrequency ablation in selected cases of isolated lymph node metastases as an alternative to traditional therapies.
  • [MeSH-major] Carcinoma, Papillary / ultrasonography. Lymph Nodes / ultrasonography. Neck / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Follow-Up Studies. Humans. Lymphatic Metastasis. Neoplasm Staging. Sensitivity and Specificity

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  • (PMID = 17684621.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 39
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5. Schmidt D, Szikszai A, Linke R, Bautz W, Kuwert T: Impact of 131I SPECT/spiral CT on nodal staging of differentiated thyroid carcinoma at the first radioablation. J Nucl Med; 2009 Jan;50(1):18-23
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  • In addition to planar whole-body scintigraphy, SPECT/CT of the neck was performed using a hybrid camera combining a double-head SPECT camera with either a 2-slice (n=23) or a 6-slice (n=34) spiral CT scanner.
  • In particular, SPECT/CT reclassified as benign 6 of 11 lesions considered to be lymph node metastases and 11 of 15 lesions considered to be indeterminate.
  • Furthermore, SPECT/CT allowed the identification of 11 lymph node metastases classified as thyroid remnant or as indeterminate on planar imaging.
  • CONCLUSION: SPECT/CT determines lymph node involvement at radioablation performed for thyroid cancer more accurately than does planar imaging.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Iodine Radioisotopes / metabolism. Lymph Nodes / pathology. Lymph Nodes / radiography. Lymph Nodes / radionuclide imaging. Lymph Nodes / surgery. Male. Middle Aged. Neoplasm Staging. Tomography, Emission-Computed, Single-Photon. Tomography, Spiral Computed. Whole Body Imaging

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  • [CommentIn] J Nucl Med. 2009 Aug;50(8):1386; author reply 1386 [19617337.001]
  • (PMID = 19091884.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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6. Mack MG, Rieger J, Baghi M, Bisdas S, Vogl TJ: Cervical lymph nodes. Eur J Radiol; 2008 Jun;66(3):493-500
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  • [Title] Cervical lymph nodes.
  • The lymph node staging is a very important prognostic parameter for patients with presenting with head neck cancer and is influencing the selection of the different therapeutic strategies including surgery, chemotherapy, radiotherapy or a combination of them.
  • The accuracy of imaging techniques, such as US, MR imaging, and CT, depends on the appropriateness of radiological criteria used for diagnosing lymph node metastases.
  • Size of nodes and evidence of necrosis are still the most important radiological criteria.
  • A spherical lymph node larger than 10mm is an indicator for a malignant node, whereas an oval shape and/or a fatty hilus are more benign signs.
  • But there are many limitations and different cut offs published in the literature, indicating that the size of a lymph node is not a reliable criteria for the assessment of lymph nodes in the head and neck region.
  • Today new high-resolution MRI sequences and the development of specific contrast agents are offering new possibilities in the diagnostic work-up of head and neck lymph nodes.
  • This is causing a signal decrease on T2-weighted MR images in benign lymph nodes after administration of USPIO's, whereas malignant lymph nodes do not show a significant signal decrease.
  • Based on the fact, that the size evaluation of lymph nodes in the head and neck has not changed during the last decade, this paper will mainly focus on MRI with new contrast agents and new techniques as diffusion weighted imaging (DWI).
  • [MeSH-major] Diagnostic Imaging. Head and Neck Neoplasms / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Contrast Media. Dextrans. Ferrosoferric Oxide. Humans. Iron. Lymph Nodes / pathology. Magnetite Nanoparticles. Neoplasm Invasiveness / diagnosis. Neoplasm Staging. Oxides. Prognosis

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  • (PMID = 18337039.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
  • [Number-of-references] 45
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7. Yoshimura Y, Nariai Y, Obara S, Mishima K, Yoshimura H, Maruyama R: Development or existence of non-metastatic lymph nodes in the previously operated neck: a good prognostic sign for oromaxillary squamous cell carcinoma? Oral Oncol; 2005 Apr;41(4):404-15
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  • [Title] Development or existence of non-metastatic lymph nodes in the previously operated neck: a good prognostic sign for oromaxillary squamous cell carcinoma?
  • The aim of this study is to clarify the clinicopathological features of patients having non-metastatic lymph nodes in the previously operated neck for oromaxillary squamous cell carcinoma (OSCC).
  • The clinicopathological factors of 9 such patients were comparatively analyzed with those of 78 other patients who underwent neck dissection (ND).
  • (1) These 9 patients were alive and without OSCC for periods ranging from 1 year to 15 years and 9 months since their initial cancer treatments. (2) The interval between ND and clinical and/or imaging recognition of newly developed lymph nodes with suspicion of recurrence was significantly longer in these 9 patients. (3) The initially removed lymph nodes tended to be in a less advanced stage of disease. (4) Retrospectively, discrimination of non-metastatic lymph nodes from metastatic nodes was difficult in only one patient. (5) Each of the extirpated lymph nodes from 7 of the 9 patients showed a varying grade of reactive lymphadenitis on histopathology.
  • In conclusion, the occurrence of benign hyperplastic lymph nodes in the previously operated neck region suggested favorable prognosis, though the immunological mechanism is not understood.
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 15792613.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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8. Nakamura T, Sumi M: Nodal imaging in the neck: recent advances in US, CT and MR imaging of metastatic nodes. Eur Radiol; 2007 May;17(5):1235-41
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  • [Title] Nodal imaging in the neck: recent advances in US, CT and MR imaging of metastatic nodes.
  • The presence of lymph node metastasis in the neck in patients with head and neck cancer is an important prognostic determinant in staging cancers and in planning surgery and chemo- and radiotherapy for the cancer patients.
  • Therefore, metastatic nodes should be effectively differentiated from benign lymphadenopathies and nodal lymphomas.
  • Here, we review recent advances in the diagnostic imaging of metastatic nodes in the neck, with emphasis placed on the diagnostic performance of MR imaging, Doppler sonography, and CT.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Neoplasm Staging. Tomography, X-Ray Computed. Ultrasonography, Doppler

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  • (PMID = 17252236.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 45
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9. Krestan C, Herneth AM, Formanek M, Czerny C: Modern imaging lymph node staging of the head and neck region. Eur J Radiol; 2006 Jun;58(3):360-6
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  • [Title] Modern imaging lymph node staging of the head and neck region.
  • The aim of this paper is to describe the modern imaging methods, their techniques, ability, and performance in staging head and neck lymph nodes.
  • Also, the imaging morphologies of benign and malignant lymph nodes according to the different imaging techniques will be delineated.
  • Imaging examples of the different modalities of benign and malignant transformed lymph nodes will be demonstrated.
  • Furthermore, the diagnostic sensitivity of each modality will be delineated and further aspects of modern lymph node staging of the head and neck region such as those with special contrast agents will be described.
  • Also the value of biopsy techniques including recently developed ultrasonography guided needle biopsy with molecular analysis of the cells of about 97-100% accuracy in diagnosing benign from malignant lymph nodes will be mentioned.
  • Overall, the reader will get an overview of the present imaging modalities to potentially stage correctly lymph nodes in the head and neck region to facilitate the therapeutic procedure.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology
  • [MeSH-minor] Biopsy, Needle / methods. Contrast Media / administration & dosage. Diagnosis, Differential. Ferric Compounds. Humans. Image Enhancement / methods. Lymphatic Metastasis. Magnetic Resonance Imaging / methods. Medical Illustration. Neoplasm Staging. Sensitivity and Specificity. Tomography, X-Ray Computed / methods. Ultrasonography, Doppler, Color / methods

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  • (PMID = 16687230.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
  • [Number-of-references] 28
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10. Dangore-Khasbage S, Degwekar SS, Bhowate RR, Banode PJ, Bhake A, Choudhary MS, Lohe VK: Utility of color Doppler ultrasound in evaluating the status of cervical lymph nodes in oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Aug;108(2):255-63
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  • [Title] Utility of color Doppler ultrasound in evaluating the status of cervical lymph nodes in oral cancer.
  • STUDY DESIGN: In a prospective study, 70 cervical lymph nodes in 30 known primary oral cancer patients were evaluated with CDUS during a period of 8 months.
  • The intranodal perfusion sites and vascular resistance were the key CDUS features used to differentiate between reactive and metastatic cervical lymph nodes.
  • Histopathologic confirmations were obtained by excisional biopsy of the lymph nodes.
  • The results of preoperative clinical palpation of cervical lymph nodes and CDUS evaluation were compared with histopathologic outcome.
  • RESULTS: Clinical evaluation suspected 61 cervical lymph nodes to be malignant.
  • According to the CDUS, out of 70 nodes, 49 lymph nodes showed features of benign lymphadenopathy and 21 lymph nodes showed features of malignant lymphadenopathy, whereas histopathologic evaluations were in favor of reactive for 57 (81.42%) and for malignant lymphadenopathy in 13 (18.57%).
  • [MeSH-major] Lymph Nodes / ultrasonography. Lymphatic Metastasis / ultrasonography. Mouth Neoplasms / pathology. Ultrasonography, Doppler, Color
  • [MeSH-minor] Female. Humans. Lymphatic Diseases / pathology. Lymphatic Diseases / ultrasonography. Male. Neck. Neoplasm Staging / methods. Prospective Studies. Regional Blood Flow. Sensitivity and Specificity. Sentinel Lymph Node Biopsy. Statistics, Nonparametric

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  • (PMID = 19272807.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Pietarinen-Runtti P, Apajalahti S, Robinson S, Passador-Santos F, Leivo I, Mäkitie AA: Cystic neck lesions: clinical, radiological and differential diagnostic considerations. Acta Otolaryngol; 2010 Feb;130(2):300-4
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  • [Title] Cystic neck lesions: clinical, radiological and differential diagnostic considerations.
  • CONCLUSIONS: Metastatic disease should always be considered as a potential differential diagnosis in the adult patient with a cystic neck lesion.
  • OBJECTIVES: The most common cause of a cystic neck lesion in young adults is a branchial cleft cyst (BCC).
  • In older patients metastatic lymph nodes may be easily misdiagnosed as BCC.
  • This study aimed to investigate the incidence of unsuspected carcinoma in routinely excised cervical cysts at a tertiary care teaching hospital and to determine the characteristics of benign BCC and cystic malignancy in preoperative imaging.
  • PATIENTS AND METHODS: A total of 196 consecutive adult patients operated on with the initial diagnosis of benign lateral cervical cyst were identified and the hospital charts and imaging studies were reviewed.
  • Therefore, the incidence of unsuspected carcinoma in the cystic neck lesions initially diagnosed as BCC was 3.6%.
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Incidence. Male. Middle Aged. Neck. Neoplasm Staging. Prevalence. Survival Rate. Young Adult

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  • (PMID = 19593684.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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12. Boi F, Maurelli I, Pinna G, Atzeni F, Piga M, Lai ML, Mariotti S: Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma. J Clin Endocrinol Metab; 2007 Jun;92(6):2115-8
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  • [Title] Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma.
  • OBJECTIVE: The aim of the study was to evaluate the usefulness of calcitonin (CT) assay in fine-needle aspiration biopsy (FNAB) wash-out fluid alone or combined with cytology in the presurgical study of medullary thyroid carcinoma (MTC) patients with thyroid nodules (TNs) and of suspicious neck MTC recurrences/metastases.
  • SUBJECTS AND METHODS: A total of 36 ultrasound-guided FNABs were performed in neck masses from 23 patients with borderline or high basal and pentagastrin-stimulated serum CT.
  • Cytology and CT-FNAB were performed on a total of 18 TNs and three neck lymph nodes (LNs) from 12 patients examined before thyroidectomy, and on six suspicious local recurrences (LRs) and nine LNs from nine totally thyroidectomized MTC patients.
  • Of the 15 negative CT-FNAB suspicious masses (eight TNs, six LNs, and one LR), five displayed a benign lesion at histology.
  • The remaining 10 cases, all with benign cytology, were not operated on, and no evidence of MTC was detected at follow-up.
  • [MeSH-minor] Adult. Aged. Body Fluids / metabolism. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Thyroid Nodule / metabolism. Thyroid Nodule / pathology

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  • (PMID = 17405835.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9007-12-9 / Calcitonin
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13. Bisdas S, Baghi M, Huebner F, Mueller C, Knecht R, Vorbuchner M, Ruff J, Gstoettner W, Vogl TJ: In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck. Eur Radiol; 2007 Jan;17(1):251-7
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  • [Title] In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck.
  • Benign and malignant neoplasms as well as metastatic lymph nodes of 39 patients were examined using localized single voxel magnetic resonance spectroscopy (MRS) [repetition time (TR) 1500, echo time (TE) 135) at 1.5 T.
  • The Cho/Cr ratios in all malignant neoplasms (mean: 5.2, range: 1.7-17.8) were significantly elevated relative to those in the normal muscle structures (mean: 0.9, range: 0.2-1.4), while those in the benign neoplasms were elevated (mean: 24.4, range: 1.4-59.7) with respect to those in the malignant ones.
  • The average Cho/Cr ratio in the metastatic lymph nodes was significantly higher (mean: 4.8, range: 3.3-5.6) than that for benign lymphoid hyperplasia (mean: 2.2, range: 1.0-3.0).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Magnetic Resonance Spectroscopy. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 16703309.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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14. Seyhan T, Borman H, Bal N: Malignant eccrine spiradenoma of the scalp. J Craniofac Surg; 2008 Nov;19(6):1608-12
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  • Malignant eccrine spiradenoma is a rare neoplasm generally arising from long-standing benign eccrine spiradenomas; it is rarely seen on the scalp.
  • A 27-year-old woman with a malignant eccrine spiradenoma of the scalp, which had occurred 8 months after the inadequate excision of a benign eccrine spiradenoma, was treated at our hospital.
  • A biopsy of the sentinel lymph nodes in the right periparotid and left occipital regions was performed, and the nodes showed no metastases.
  • We report a case of a malignant eccrine spiradenoma of the scalp with cranial involvement that arose from an inadequately removed, long-standing, benign eccrine spiradenoma in a young patient.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Alopecia / diagnosis. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy. Skin Transplantation

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  • (PMID = 19098562.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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15. Wang CP, Lee CY, Lou PJ, Yen RF, Hsiao JK, Ko JY: Role of ultrasound-guided fine needle aspiration in assessing the impalpable cervical node with increased 18F-fluorodeoxyglucose uptake on positron emission tomography scanning: preliminary communication. J Laryngol Otol; 2008 Dec;122(12):1349-53

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  • This paper reports the use of ultrasound-guided fine needle aspiration to determine the nature of impalpable cervical nodes that are positive on positron emission tomography scanning.
  • METHODS: Ultrasound-guided fine needle aspiration was performed in 10 cancer patients with suspicious cervical nodes revealed by positron emission tomography scan.
  • The lymph nodes were located in the supraclavicular region in four patients, the level II region in four, the level IV region in one and the accessory chain in one.
  • Cytological examination revealed a benign or reactive lesion in two patients, who at the time of writing were alive and well, 19 and 36 months after examination.
  • CONCLUSIONS: Ultrasound-guided fine needle aspiration is a minimally invasive procedure which enables cytological examination of suspicious cervical lymph nodes detected by positron emission tomography scanning, allowing further treatment to be planned.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Lymph Nodes / pathology. Positron-Emission Tomography / methods
  • [MeSH-minor] Adult. Aged. Female. Fluorodeoxyglucose F18. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck. Neoplasm Staging / methods. Radiopharmaceuticals. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Interventional. Whole Body Imaging

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  • (PMID = 18549513.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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16. Lind P, Igerc I, Kohlfürst S: [Diagnosis, treatment and follow-up in the case of differentiated thyroid cancer]. Wien Med Wochenschr; 2005 Oct;155(19-20):429-35
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  • Treatment of thyroid cancer includes total thyroidectomy and staging lymphadenectomy, in the case of lymph node metastases, radical neck dissection of the ipsilateral side.
  • As growth of benign and malignant thyroid cells depends on TSH stimulation, thyroid hormone therapy using TSH suppressive doses (TSH, <0.03 mU/l) follows radioiodine remnant ablation.
  • Standard follow-up of differentiated thyroid cancer includes measurement of serum thyroglobulin, US of the neck and I-131 whole-body scintigraphy (I-131 WBS).
  • In case of elevated thyroglobulin, US is the method of choice to detect local recurrences and lymph node metastases of the neck.
  • [MeSH-major] Carcinoma / surgery. Iodine Radioisotopes / therapeutic use. Neoplasm Recurrence, Local / diagnosis. Thyroid Neoplasms / surgery. Thyroidectomy
  • [MeSH-minor] Biopsy, Fine-Needle. Combined Modality Therapy. Diagnostic Imaging. Humans. Lymph Nodes / pathology. Neck Dissection. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Thyroid Function Tests

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  • (PMID = 16424998.001).
  • [ISSN] 0043-5341
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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17. Kung B, Aftab S, Wood M, Rosen D: Malignant melanoma metastatic to the thyroid gland: a case report and review of the literature. Ear Nose Throat J; 2009 Jan;88(1):E7
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  • We describe the case of a 68-year-old man who presented with a neck mass in the posterior triangle.
  • He underwent a left modified radical neck dissection, and the mass was discovered to be a positive lymph node.
  • Patients who present with a thyroid nodule and who have a history of malignancy present a diagnostic dilemma: Is the nodule benign, a new primary, or a distant metastasis?
  • [MeSH-major] Melanoma / secondary. Neoplasm Invasiveness / pathology. Thyroid Neoplasms / secondary. Thyroid Nodule / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Follow-Up Studies. Humans. Immunohistochemistry. Lymph Nodes / pathology. Male. Neck Dissection. Neoplasm Staging. Risk Assessment. Thyroidectomy / methods. Treatment Outcome

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  • (PMID = 19172560.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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18. Pietniczka-Załeska M, Kukwa A: [The parotid gland's tumours in material of Otolaryngology Department Medical Academy in Warsaw in 1990-2006]. Otolaryngol Pol; 2008;62(4):395-9

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  • In 222 cases they made a partial parotidectomy, in 63 total, in 11 radical parotidectomy, in 21 cases radical parotidectomy widened for the radical neck dissection, where 8 patients were subjected to the radical saving surgery - subtotal petrosectomy and craniotomy.
  • The frequency of incidence of benign tumours was 81%.
  • (1) There were 81% cases of benign neoplasm and 19% malignant neoplasm in presented material. (2) The result of parotid gland treatment depends on tumor's histopathology, the period of disease, the size of tumour, its expansion into the neighbourhood, infiltrating of the facial nerve and metastases into the lymph nodes. (3) Radical resection of tumour and metastases, reconstructing the continuity of tissues and maintaining the quality of patients life, should be the principle of surgical treatment.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18837210.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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19. Koo BS, Lim HS, Lim YC, Yoon YH, Kim YM, Park YH, Rha KS: Occult contralateral carcinoma in patients with unilateral papillary thyroid microcarcinoma. Ann Surg Oncol; 2010 Apr;17(4):1101-5
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  • The frequency, pattern, and predictive factors for occult contralateral carcinoma in these patients were analyzed with respect to the following variables: age, gender, tumor size, multifocality of primary tumor, presence of perithyroidal invasion, lymphovascular invasion or capsular invasion, presence of central lymph node metastasis, and the presence of coexistent benign nodules in the contralateral lobe based on preoperative evaluation and final pathology.
  • In multivariate analysis, multifocality of the primary tumor (P = 0.026, odds ratio = 7.714) and the presence of coexistent benign nodule in the contralateral lobe by preoperative evaluation (P = 0.036, odds ratio = 3.500) were independent predictive factors for occult contralateral PTMC presence.
  • However, there were no significant differences between the presence of occult contralateral carcinomas and age, gender, tumor size, perithyroidal invasion, lymphovascular invasion, capsular invasion, central lymph node metastasis, and coexistent benign nodules by final pathology.
  • [MeSH-major] Carcinoma, Papillary / pathology. Lymph Nodes / pathology. Thyroid Neoplasms / pathology. Thyroidectomy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Risk Factors. Treatment Outcome

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  • (PMID = 20066517.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Stodulski D, Rzepko R, Kowalska B, Stankiewicz C: [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review]. Otolaryngol Pol; 2007;61(5):687-93
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  • BACKGROUND: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands.
  • Own material is presented because of rarity and clinicopathologic specificity of this neoplasm.
  • The following clinical factors were evaluated: age, sex, symptoms (time of lasting, evolution), tumor size, invasion of the adjacent structures and facial nerve, neck nodes, clinical stage, treatment outcome.
  • One pathologist reviewed histological material of 18 out of 19 patients who had been operated and pathological factors such as sensitivity and accuracy of fine needle aspiration biopsy, grade, histology and proportion of malignant component in tumor, lymph nodes metastases were analyzed.
  • Duration of symptoms of benign PA was from 2 to 40 years (mean 17.8 years).
  • In 14 patients, the neck was evaluated clinically as No, in 5, examination identified enlarged lymph nodes.
  • Adjacent structures were invaded by neoplasm in 5 cases.
  • Pathologic examination showed metastases to the lymph nodes in 7 out of 10 patients with prior neck dissection.
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18552001.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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21. Sheth S, Hamper UM: Role of sonography after total thyroidectomy for thyroid cancer. Ultrasound Q; 2008 Sep;24(3):147-54
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  • High-resolution neck ultrasound plays a vital role in the evaluation and management of patients after total thyroidectomy for thyroid cancer.
  • This technique is increasingly used by endocrinologists and head and neck surgeons to detect potential locoregional recurrences or metastases and map malignant lymph nodes before reoperation.
  • It is also invaluable as guidance for fine-needle aspiration of suspicious lesions.Thorough knowledge of the compartments of the neck and meticulous scanning technique are essential for success.The purpose of this article is to review the common pattern of recurrences of differentiated thyroid cancer, describe our scanning protocol, and depict the characteristics of benign, indeterminate, and suspicious lesions in the postthyroidectomy neck.
  • [MeSH-major] Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / ultrasonography. Thyroid Neoplasms / radiography. Thyroid Neoplasms / surgery. Thyroidectomy. Ultrasonography / methods

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  • (PMID = 18776787.001).
  • [ISSN] 1536-0253
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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22. Li G, Wu YT, Chen Y, Li TJ, Gao Y, Zhang J, Zhang ZY, Ma XC: Soft-tissue osteoma in the pterygomandibular space: report of a rare case. Dentomaxillofac Radiol; 2009 Jan;38(1):59-62
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  • Osteoma is a slow-growing, benign and uncommon neoplasm located primarily in the region of the maxillofacial skeleton.
  • Clinical examination did not reveal any extraoral swelling, facial asymmetry or difficulty in mouth opening, and the regional lymph nodes were non-palpable.
  • [MeSH-major] Head and Neck Neoplasms / radiography. Osteoma / radiography. Soft Tissue Neoplasms / radiography

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  • (PMID = 19114426.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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23. Antony FC, Sanclemente G, Shaikh H, Trelles AS, Calonje E: Pigment synthesizing melanoma (so-called animal type melanoma): a clinicopathological study of 14 cases of a poorly known distinctive variant of melanoma. Histopathology; 2006 May;48(6):754-62
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  • The head and neck represented the most common site.
  • The clinical diagnosis was of melanoma in seven cases, blue naevus in three cases, benign naevus in three cases and a pigmented basal cell carcinoma in one case.
  • Six patients had no recurrence, three had local recurrence in the form of satellite nodules adjacent to the scar, four had spread to the regional lymph nodes and one patient had distant metastases to the liver.
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Immunohistochemistry. MART-1 Antigen. Male. Melanocytes / chemistry. Melanocytes / pathology. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local. Nevus, Blue / metabolism. Nevus, Blue / pathology. Nevus, Pigmented / metabolism. Nevus, Pigmented / pathology. S100 Proteins / analysis

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  • (PMID = 16681693.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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24. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
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  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The patient was a 16-year-old girl with a 3-year history of a painless mass on the right side of her neck.
  • Cervical lymph nodes were evaluated with ultrasonography preoperatively to exclude metastasis and no pathologic lymph nodes were noted.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Ferlito A, Devaney KO, Rinaldo A: Primary carcinoid tumor of the middle ear: a potentially metastasizing tumor. Acta Otolaryngol; 2006 Mar;126(3):228-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The concept of a carcinoid tumor in the gastrointestinal tract and lung is well established; less often, patients develop carcinoid tumors in the head and neck region.
  • One particularly uncommon site of origin of carcinoid tumors in the head and neck area is the middle ear.
  • Middle ear carcinoids have previously been approached as benign entities, lacking any capacity for metastasizing.
  • This in turn suggests that, as is the case with pulmonary carcinoid tumors, middle ear carcinoids should be thought of as low-grade malignancies which, while relatively slow-growing, nevertheless possess a limited capacity for spreading to regional lymph nodes.
  • [MeSH-major] Carcinoid Tumor / secondary. Ear Neoplasms / pathology. Ear, Middle. Lymphatic Metastasis / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Immunohistochemistry. Male. Neoplasm Staging. Prognosis. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 16618645.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 21
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26. Hindié E, Zanotti-Fregonara P, Duron F, Keller I, Bouchard P, Devaux JY: Should 'low-risk' thyroid cancer patients with residual thyroglobulin be re-treated with iodine 131? Clin Endocrinol (Oxf); 2007 Mar;66(3):329-34
Hazardous Substances Data Bank. THYROGLOBULIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This finding was interpreted as benign (131)I thymic uptake.
  • One patient had a gradual increase in the thyroglobulin level, and underwent resection of nonfunctioning neck lymph nodes.
  • The authors also briefly discuss the hypothesis that enhanced thymus might be a source of benign thyroglobulin secretion.
  • [MeSH-minor] Adult. Biomarkers / blood. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Iodine Radioisotopes / therapeutic use. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Prospective Studies. Radiopharmaceuticals / therapeutic use. Retreatment. Risk Assessment / methods. Thymus Gland / radionuclide imaging. Thymus Gland / secretion. Thyroidectomy. Whole-Body Counting

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  • (PMID = 17302864.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 9010-34-8 / Thyroglobulin
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27. Schmidt M, Dietlein M, Schröder U, Schicha H: False-positive uptake of I-131 in a laryngocele mimicking thyroid remnant after thyroidectomy for papillary thyroid carcinoma. Clin Nucl Med; 2006 Nov;31(11):716-7
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  • Radioiodine therapy revealed intense radioiodine uptake of the neck, which was interpreted as thyroid remnant tissue.
  • Follow-up whole-body scans with iodine-131 in hypothyroidism 3 months and 1 year after radioiodine therapy revealed focal uptake in the neck.
  • Computed tomography and gadolinium-enhanced MRI of the neck demonstrated an ovoid lesion in the larynx without gadolinium enhancement.
  • Neither thyroid remnant tissue nor enlarged cervical lymph nodes could be demonstrated either on CT or on MRI.
  • Further examination of the patient in the ear, nose and throat department confirmed the finding of a laryngocele and biopsies demonstrated benign tissue.
  • Follow-up whole-body scans with iodine-131 in hypothyroidism 3 years and after injection of rhTSH 5 years after radioiodine therapy reproduced the focal uptake in the neck.
  • [MeSH-major] Carcinoma, Papillary / radionuclide imaging. Iodine Radioisotopes. Laryngeal Diseases / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging

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  • (PMID = 17053394.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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28. Reddy SS, Gadre SA, Adegboyega P, Gadre AK: Multiple pilomatrixomas: case report and literature review. Ear Nose Throat J; 2008 Apr;87(4):230-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pilomatrixoma is a rare, benign, circumscribed, calcifying epithelial neoplasm that is derived from hair matrix cells.
  • Based on the results of the clinical examination, she was provisionally diagnosed with either calcified sebaceous cysts or calcified lymph nodes.

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  • (PMID = 18478800.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Surgical treatment of benign tumours consisted, in 50% of cases, in superficial paroditectomy and in approximately 30% of total paroditectomy.
  • The lateral neck dissection most frequently carried out was of functional type in 54% and selective type in 46% with removal of levels I-III and II-IV in approximately 60% of cases.
  • Sentinel lymph node was observed in a limited number of centres.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.
  • Oncological results obtained were compared with those reported in the literature: in fact for all benign neoplasms relapse ratings are about 5%, while for malignant tumours the worst prognosis was in squamous cell carcinoma with median of 37.7 on survival and metastasis rate of 16.5%.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures. Surveys and Questionnaires

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  • [ErratumIn] Acta Otorhinolaryngol Ital. 2005 Oct;25(5):following 337
  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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30. Zhang J, Ji J, Yuan F, Chen J, Yan M, Yu YY, Liu BY, Yin HR, Lin YZ, Zhu ZG: [Transcription factor Sp1 expression in gastric cancer and its prognostic value]. Zhonghua Zhong Liu Za Zhi; 2005 Sep;27(9):531-3
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  • METHODS: By using immunohistochemistry, we studied the Sp1 expression patterns in 65 cases of gastric cancer with various clinico-pathologic characteristics, and 40 normal gastric mucosa specimens obtained from patients who underwent partial gastrectomy for benign gastric diseases.
  • The positively stained glandular cells were mainly limited to those in the neck region.
  • Sp1 protein expression was closely related to the depth of tumor invasion and TNM stage (P = 0.001, P = 0.026), but not related to the number of metastatic lymph nodes and Lauren's classification (P = 0.306, P = 0.667).
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Gastric Mucosa / metabolism. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis

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  • (PMID = 16438849.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Sp1 Transcription Factor
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31. Lemaire A, Nikolic I, Petersen T, Haney JC, Toloza EM, Harpole DH Jr, D'Amico TA, Burfeind WR: Nine-year single center experience with cervical mediastinoscopy: complications and false negative rate. Ann Thorac Surg; 2006 Oct;82(4):1185-9; discussion 1189-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pathology included lung cancer (n = 1,459), metastatic disease (n = 78), lymphoma (n = 51), and other benign disease (n = 557).
  • Thirty-two (57%) of the false negatives were due to metastatic disease in lymph nodes not normally biopsied during cervical mediastinoscopy (levels 5, 6, 8, or 9).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. False Negative Reactions. Female. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neck. Neoplasm Staging. Retrospective Studies

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  • (PMID = 16996905.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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