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[Title] Enhanced progenitor cell recruitment and endothelial repair after selective endothelial injury of the mouse kidney.

Primary and/or secondary injury of the renal microvascular endothelium is a common finding in various renal diseases.

However, these mechanisms have so far not been studied after selective microvascular injury in the kidney.

The present study investigated the time course of EPC and HSC stimulation and homing following induction of selective EC injury in the mouse kidney along with various angiogenic factors potentially involved in EC repair and progenitor cell stimulation.

Progenitor cells could be first detected in the circulation and the spleen before they selectively homed to the diseased kidney.

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(PMID = 20237239.001).

[ISSN] 1522-1466

[Journal-full-title] American journal of physiology. Renal physiology

[ISO-abbreviation] Am. J. Physiol. Renal Physiol.

[Language] ENG

[Grant] United States / NIDDK NIH HHS / DK / R01 DK045462; United States / NIDDK NIH HHS / DK / DK-052783; United States / NIDDK NIH HHS / DK / DK-054602; United States / NIDDK NIH HHS / DK / DK-45462

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Angiogenic Proteins; 11096-26-7 / Erythropoietin; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.10.1 / Receptor, TIE-2

[Other-IDs] NLM/ PMC2886821

   

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[Title] Living with a kidney transplant: a qualitative investigation of quality of life.

Research has shown that transplantation improves quality of life for patients with end stage renal disease (ESRD), although it does not return to pre-kidney failure levels.

This study used focus groups to explore the experience of living with a transplanted kidney.

These may necessitate constant vigilance, reduced spontaneity and preoccupation with self-care to maintain the kidney's health; being treated differently from others; pressure not to let themselves and others down; and the urge to increase their knowledge about their condition.

[MeSH-major] Kidney Transplantation. Quality of Life. Survivors / psychology

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(PMID = 17584816.001).

[ISSN] 1359-1053

[Journal-full-title] Journal of health psychology

[ISO-abbreviation] J Health Psychol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance.

We previously showed that administration and anti-donor anti-class II serum on the day of transplantation induce tolerance to a kidney allograft in the LEW-1W to LEW-1A strain combination.

In this study, we used DNA microarrays to compare gene patterns involved in anti-donor anti-class II tolerated or untreated syngeneic kidney transplants in this strain combination.

Through this model, we showed that AKT1 gene, WNT pathway and NO synthesis are strictly connected to each other and may play an important role in kidney tolerance and rejection processes, with AKT1 gene being the center of this complex network of interactions.

[MeSH-major] Gene Expression Regulation. Kidney Transplantation / immunology. Proto-Oncogene Proteins c-akt / genetics. Transplantation Tolerance

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[Copyright] © 2010 Wiley-Liss, Inc.

(PMID = 20607729.001).

[ISSN] 1097-4644

[Journal-full-title] Journal of cellular biochemistry

[ISO-abbreviation] J. Cell. Biochem.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Histocompatibility Antigens Class II; 0 / Wnt Proteins; 31C4KY9ESH / Nitric Oxide; EC 2.7.11.1 / Akt1 protein, rat; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt

   

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[Title] [Effect of tongshenluo capsule on the components of extracellular matrix and their metabolism in kidney of rats with diabetic nephropathy].

OBJECTIVE: To investigate the effect of Tongshenluo Capsule (TSL) on the components of extracellular matrix (ECM) and their metabolism in kidney of rats with diabetic nephropathy (DN), and to explore its mechanism of kidney protecting.

Levels of fasting blood glucose (FBG) and 24-h urinary micro-content of albumin (24 h mAlb) were determined dynamically; the serum glycosyl hemoglobin (HbA1c)was determined after the last medication; the ultrastructural changes of kidney were observed by transmission electron microscope; the expressions of collagen IV (IV-C), fibronctin (FN), laminin(LN), and the ECM metabolism influencing factors, including MMP-2, tissue inhibitor of metalloproteinase (TIMP-2), transfer growth factor-beta1 (TGF-beta1) in renal tissue were detected by immunohistological chemistry and image collecting analytical system.

CONCLUSION: TSL plays a role of kidney protection by decreasing the ECM components expression and regulate ECM metabolism.

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(PMID = 17526172.001).

[ISSN] 1003-5370

[Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi

[Language] CHI

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / Capsules; 0 / Collagen Type IV; 0 / Drugs, Chinese Herbal; 0 / Fibronectins; 0 / Laminin

   

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[Title] [Expression of nestin in human kidney and its clinical significance].

OBJECTIVE: To study the expression and significance of nestin (a type of cytoskeletal protein) in normal and diseased human kidneys.

METHODS: Diseased kidney tissues were obtained from needle biopsies in 32 patients with glomerulonephritis (including 8 cases of membranous glomerulopathy, 3 cases of focal segmental glomerulosclerosis, 17 cases of IgA nephropathy with proteinuria and 4 cases of IgA nephropathy without proteinuria).

Control kidney tissues were obtained from nephrectomy specimens for renal tumors.

The expression of nestin in the control kidney tissues was studied using immunoelectronic microscopy and immunohistochemistry.

The expression of nestin in the diseased kidney tissues was detected by immunohistochemistry and real-time reverse transcription-polymerase chain reaction.

RESULTS: In normal kidney tissues, nestin was detected at the periphery of glomerular capillary loops.

However, the glomerular nestin expression levels in cases of IgA nephropathy with proteinuria, membranous glomerulopathy and focal segmental glomerulosclerosis were significantly lower than those in the normal kidneys and IgA nephropathy without proteinuria.

CONCLUSION: Nestin may play an important role in maintaining the normal function of podocytes in human kidney.

[MeSH-minor] Adult. Gene Expression Regulation. Humans. Immunohistochemistry. Kidney. Kidney Diseases / metabolism. Kidney Diseases / pathology. Kidney Glomerulus / metabolism. Kidney Glomerulus / pathology. Middle Aged. Nestin. Proteinuria / metabolism

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(PMID = 18956648.001).

[ISSN] 0529-5807

[Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology

[ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin

   

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[Title] A composite kidney stone phantom with mechanical properties controllable over the range of human kidney stones.

A novel composite kidney stone phantom has been developed.

This stone phantom is producible with mechanical properties mimicking the range of tensile fracture strength and acoustic properties of human kidney stones and is an inorganic/organic composite material, as are natural kidney stones.

Diametral compression testing was used to measure tensile fracture strength, which determines the acoustic comminution behavior of kidney stones.

Both the tensile fracture strength (controllable from 1 to approximately 5 MPa) and acoustic properties (C(L) = 2700-4400 m/s and C(T)=1600-2300m/s) of these composite phantom stones match those of a wide variety of human kidney stones.

[MeSH-major] Kidney Calculi / physiopathology. Phantoms, Imaging

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(PMID = 19878912.001).

[ISSN] 1878-0180

[Journal-full-title] Journal of the mechanical behavior of biomedical materials

[ISO-abbreviation] J Mech Behav Biomed Mater

[Language] eng

[Grant] United States / NIDDK NIH HHS / DK / R01 DK052985; United States / NIDDK NIH HHS / DK / R01 DK052985; United States / NIDDK NIH HHS / DK / R37 DK052985

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] Netherlands

[Other-IDs] NLM/ NIHMS498637; NLM/ PMC3756310

   

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[Title] Doppler ultrasonographic indexes in kidney transplant recipients: its relationship with kidney function.

INTRODUCTION: Doppler ultrasonography (DU) is mostly used for assessment of both graft and native kidneys' vascular status.

In this study, correlation between the DU indexes and kidney allograft function was evaluated.

MATERIALS AND METHODS: Hospital records of 273 kidney transplant patients (154 men and 119 women) were reviewed.

In all cases, DU had been performed 1 month after kidney transplantation.

We evaluated the data on the resistive index (RI) and pulsatility index (PI) in the interlobar arteries and renal artery stenosis (RAS), and renal vessels thrombosis were determined.

Concurrent serum creatinine and cyclosporine values were assessed in relation to the DU findings.

RESULTS: The RI and PI had significant linear correlations with serum creatinine (P = .03 and P = .002, respectively).

Also, there were direct linear correlations between the age of the patients and the RI and PI values.

Despite this finding, RI and PI were significantly lower in patients with RAS than in the patients with patent renovascular tributary (0.59 +/- 0.15 versus 0.65 +/- 0.11; P = .03 and 1.02 +/- 0.40 versus 1.18 +/- 0.46; P = .049, respectively).

There were no associations between serum cyclosporine level or panel reactive antibodies and the RI or PI.

CONCLUSIONS: The RI and PI are valuable DU markers for determining the kidney allograft function and the related vascular complications.

[MeSH-major] Kidney Transplantation / ultrasonography. Renal Artery Obstruction / ultrasonography. Thrombosis / ultrasonography

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(PMID = 19363282.001).

[ISSN] 1735-8582

[Journal-full-title] Iranian journal of kidney diseases

[ISO-abbreviation] Iran J Kidney Dis

[Language] eng

[Publication-type] Journal Article

[Publication-country] Iran

[Chemical-registry-number] 0 / Biomarkers; AYI8EX34EU / Creatinine

   

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[Title] Trends in the survival of patients diagnosed with kidney or urinary bladder cancer in the Nordic countries 1964-2003 followed up to the end of 2006.

BACKGROUND: Previous studies have shown systematic differences between the Nordic Countries in population-based relative survival following a kidney or urinary bladder cancer diagnosis.

RESULTS: The survival following bladder cancer was higher than for kidney cancer and highest for men.

Survival increased over the years in all countries, more for kidney cancer than bladder cancer.

For Danish kidney cancer patients, the rate of increase over all the years has been lower than in the other countries, especially among women, resulting in a survival in Denmark some 10-20% points lower than elsewhere in 1999-2003.

The differences were mainly found in the first year following diagnosis, where a higher excess mortality in Denmark was observed.

Survival decreased with higher age at diagnosis.

CONCLUSION: The increasing 5-year relative survival in all the Nordic countries for both kidney and bladder cancer are promising, but for kidney cancer a higher percentage detected coincidentally during an imaging investigation for other diseases could play a role.

Denmark had the lowest survival, despite their known practice of including benign conditions with invasive bladder cancers.

The lower Danish survival after kidney and bladder cancer in the first year after diagnosis could be due to later diagnosis on average, a higher co-morbidity from smoking-related diseases, and perhaps, less adequate cancer treatment and management in Denmark.

[MeSH-major] Kidney Neoplasms / mortality. Urinary Bladder Neoplasms / mortality

[MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Denmark / epidemiology. Female. Finland / epidemiology. Follow-Up Studies. Humans. Iceland / epidemiology. Incidence. Male. Mass Screening. Middle Aged. Mortality / trends. Neoplasm Staging. Norway / epidemiology. Registries. Risk Factors. Survival Analysis. Survival Rate / trends. Sweden / epidemiology

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(PMID = 20156116.001).

[ISSN] 1651-226X

[Journal-full-title] Acta oncologica (Stockholm, Sweden)

[ISO-abbreviation] Acta Oncol

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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[Title] Standard criteria donor pancreas donation status is associated with improved kidney transplant outcomes.

BACKGROUND: Organ donor characteristics can be used to predict outcomes in kidney transplantation.

We hypothesized that pancreas donation status could reflect organ quality and be predictive of kidney graft outcomes following Standard Criteria Donor (SCD) kidney transplantation.

METHODS: We performed a retrospective analysis of deceased donor kidney alone (DD KA) transplants reported to SRTR from 1992 to 2005.

Group 1 = kidney alone recipients from pancreas donors (KA, P+) and Group 2 = kidney alone recipients from non-pancreas donors (KA, P-).

CONCLUSION: Donor pancreas donation status is an independent predictor of improved outcomes of SCD kidney recipients.

Further study of the pancreas organ donor pre-procurement is warranted to optimize not only pancreas utilization but also kidney graft outcomes.

[MeSH-major] Graft Rejection / prevention & control. Graft Survival / physiology. Kidney Transplantation. Pancreas Transplantation. Tissue Donors. Tissue and Organ Procurement / standards

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(PMID = 19732097.001).

[ISSN] 1399-0012

[Journal-full-title] Clinical transplantation

[ISO-abbreviation] Clin Transplant

[Language] eng

[Publication-type] Journal Article

[Publication-country] Denmark

   

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[Title] Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells.

Ischemia causes kidney tubular cell damage and abnormal renal function.

The kidney is capable of morphological restoration of tubules and recovery of function.

We studied kidney repair in chimeric mice expressing GFP or bacterial beta-gal or harboring the male Y chromosome exclusively in bone marrow-derived cells.

Upon i.v. injection of bone marrow mesenchymal stromal cells, postischemic functional renal impairment was reduced, but there was no evidence of differentiation of these cells into tubular cells of the kidney.

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[CommentIn] J Clin Invest. 2005 Jul;115(7):1705-8 [16007248.001]

(PMID = 16007251.001).

[ISSN] 0021-9738

[Journal-full-title] The Journal of clinical investigation

[ISO-abbreviation] J. Clin. Invest.

[Language] ENG

[Grant] United States / NIDDK NIH HHS / DK / R37 DK039773; United States / NIDDK NIH HHS / DK / DK 39773; United States / NIDDK NIH HHS / DK / DK 38452; United States / NIDDK NIH HHS / DK / P01 DK038452; United States / NIDDK NIH HHS / DK / R01 DK039773

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Recombinant Proteins; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins

[Other-IDs] NLM/ PMC1159124

   

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[Title] Fatal and nonfatal hemorrhagic complications of living kidney donation.

OBJECTIVE: After anecdotal reports of severe hemorrhage from failure of surgical clips to sustain closure of renal artery stumps in live donor nephrectomies were received, this study was designed to identify specific surgical techniques that are associated with an increased risk of failure to control bleeding and might represent opportunities to improve patient safety.

BACKGROUND: Preventing complications for living kidney donors must be paramount in addressing end-stage renal failure through living kidney donation.

Open and laparoscopic approaches to living kidney donation use several vascular control methods, some of which may be more prone to failure and life-endangering hemorrhage than others.

METHODS: To define hemorrhagic complications of living kidney donation, a survey was sent to all 893 surgeon-members of the American Society of Transplant Surgeons.

Descriptive and bivariate analyses were used to ascertain study participant characteristics, most frequently used vascular control techniques, and incidence of events (death, transfusion, reexploration or conversion to open nephrectomy, or contralateral [remaining kidney] renal failure).

Among arterial control problems, 2 resulted in donor death and 2 resulted in renal failure; 19 episodes required transfusion.

Locking and standard clips applied to the renal artery were associated with the greatest risks.

CONCLUSIONS: Significant hemorrhagic complications occur with living kidney donation in both open and laparoscopic approaches.

[MeSH-major] Hemorrhage / etiology. Kidney Transplantation / adverse effects. Living Donors. Nephrectomy / adverse effects. Surgical Instruments / adverse effects

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[Cites] Clin Transplant. 1999 Feb;13(1 Pt 2):108-12 [10081646.001]

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[CommentIn] Ann Surg. 2006 Oct;244(4):629; author reply 629-30 [16998373.001]

(PMID = 16371747.001).

[ISSN] 0003-4932

[Journal-full-title] Annals of surgery

[ISO-abbreviation] Ann. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC1449959

   

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[Title] Body fat measurement in chronic kidney disease: implications in research and clinical practice.

PURPOSE OF REVIEW: The paradoxical and inverse association between body mass index and mortality risk in patients with end-stage renal disease has raised a question of whether an increased fat mass is good or bad for patients with chronic kidney disease.

The purpose of this review is to update the concept on body fat in patients with chronic kidney disease.

Following the initiation of dialysis, chronic kidney disease patients gain body weight due mainly to increased fat mass.

In predialysis chronic kidney disease, there is also an inverse association between body mass index and mortality risk.

The metabolic syndrome and a high body mass index are independent predictors for development of chronic kidney disease and end-stage renal disease, respectively.

In diabetic patients with chronic kidney disease, however, a high initial body mass index is associated with a slower decline in glomerular filtration rate.

SUMMARY: The impacts of fat mass on survival and renal function appear to vary depending upon the absence or presence, and stages of chronic kidney disease.

Further research is required for optimal nutritional management and improved outcomes of patients with chronic kidney disease.

[MeSH-major] Adipose Tissue. Kidney Failure, Chronic / pathology

[MeSH-minor] Anthropometry. Humans. Kidney Function Tests. Predictive Value of Tests. Survival Rate

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(PMID = 18089973.001).

[ISSN] 1062-4821

[Journal-full-title] Current opinion in nephrology and hypertension

[ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Number-of-references] 25

   

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[Title] The development of a real-time PCR to detect pathogenic Leptospira species in kidney tissue.

To assess the suitability of these PCR methods for diagnosis, a trial was performed on kidneys taken from adult pigs with evidence of leptospiral infection, primarily a history of reproductive disease and serological evidence of exposure to pathogenic leptospires (n=180) and aborted pig foetuses (n=24).

In a subsidiary experiment, the 'pathogenic' PCR was used to analyse kidney samples from rodents (n=7) collected as part of vermin control in a zoo, with show animals with high microagglutination titres to Leptospira species, and five were positive.

Fifteen PCR amplicons from 1 mouse, 2 rat and 14 pig kidney samples, were selected at random from positive PCRs (n=30) and sequenced.

The only successful culture was from this mouse kidney and the isolate was confirmed to be L. inadai by classical serology.

[MeSH-major] Kidney / microbiology. Leptospira / isolation & purification. Leptospirosis / veterinary. Polymerase Chain Reaction / veterinary. Swine Diseases / microbiology

[MeSH-minor] Animals. Kidney Diseases / microbiology. Kidney Diseases / veterinary. Swine. Temperature

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(PMID = 17961617.001).

[ISSN] 0034-5288

[Journal-full-title] Research in veterinary science

[ISO-abbreviation] Res. Vet. Sci.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Effect of inflammation on kidney function and pharmacokinetics of COX-2 selective nonsteroidal anti-inflammatory drugs rofecoxib and meloxicam.

We studied (a) the effects of inflammation on the renal function and pharmacokinetics of rofecoxib and meloxicam;.

(b) whether inflammation could exacerbate reduced electrolytes excretion changes observed with NSAIDs; and (c) the influence of inflammation on distribution of these drugs into the kidney.

The ratios of the kidney:plasma concentrations were not significantly altered by inflammation following either drug.

Inflammation altered kidney function, demonstrated by increases in BUN and plasma creatinine.

Since we have observed similar patterns of the effect of NSAIDs on kidney under healthy and inflammatory conditions, one may conclude that inflammation does not exacerbate the adverse effect.

[MeSH-major] Arthritis, Experimental / physiopathology. Arthritis, Rheumatoid / physiopathology. Cyclooxygenase 2 Inhibitors / pharmacokinetics. Kidney / metabolism. Kidney / physiopathology. Lactones / pharmacokinetics. Sulfones / pharmacokinetics. Thiazines / pharmacokinetics. Thiazoles / pharmacokinetics

[MeSH-minor] Administration, Oral. Animals. Area Under Curve. Kidney Function Tests. Male. Rats. Rats, Sprague-Dawley

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(PMID = 18344196.001).

[ISSN] 0260-437X

[Journal-full-title] Journal of applied toxicology : JAT

[ISO-abbreviation] J Appl Toxicol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Lactones; 0 / Sulfones; 0 / Thiazines; 0 / Thiazoles; 0QTW8Z7MCR / rofecoxib; 71125-38-7 / meloxicam

   

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[Title] Pregnancy and birth after kidney donation: the Norwegian experience.

Reports on pregnancies in kidney donors are scarce.

Linkage with the Norwegian Renal Registry provided data on pregnancies of kidney donors 1967-2002.

A random sample from the Medical Birth Registry was control group, as was pregnancies in kidney donors prior to donation.

No differences were observed in the occurrence of adverse pregnancy outcome in kidney donors and in the general population in unadjusted analysis.

Our finding of more frequent preeclampsia in pregnancies after kidney donation in the secondary analysis must be interpreted with caution, as the number of events was low.

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[CommentIn] Am J Transplant. 2009 Apr;9(4):661-8 [19344459.001]

(PMID = 18853953.001).

[ISSN] 1600-6143

[Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

[ISO-abbreviation] Am. J. Transplant.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Denmark

   

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[Title] Giant renal calculus in a solitary functioning kidney.

We report a case of giant renal calculus 230 x 140 mm in size and weighing 1,350 g in a solitary functioning kidney treated by nephrolithotomy.

A giant renal calculus in his right kidney and atrophic nonfunctioning left kidney was diagnosed by ultrasonography, IVP and CT scan.

This case is the largest and the heaviest stone reported in the literature in a solitary functioning kidney.

[MeSH-major] Kidney Calculi

[MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Nephrostomy, Percutaneous. Tomography, X-Ray Computed. Urodynamics

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(PMID = 17192742.001).

[ISSN] 0042-1138

[Journal-full-title] Urologia internationalis

[ISO-abbreviation] Urol. Int.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Switzerland

   

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[Title] Epidemiology of non-dialysis-requiring chronic kidney disease and cardiovascular disease.

PURPOSE OF REVIEW: To review recent literature about the relationship between non-dialysis-requiring chronic kidney disease and cardiovascular disease as well as possible explanatory factors.

This risk is not linearly associated with level of kidney function.

Chronic kidney disease is associated with a larger burden of traditional vascular risk factors but is also linked to abnormalities in a variety of nontraditional pathways such as dysregulation of mineral metabolism and arterial calcification, vessel stiffness and endothelial dysfunction, insulin resistance, inflammation, malnutrition, and anemia, among others.

Other novel kidney-specific proteins (e.g. renalase) may play direct mediating roles.

The relative contribution of these factors to excess cardiovascular disease in chronic kidney disease remains unclear.

SUMMARY: Recent evidence demonstrates the importance of non-dialysis-requiring chronic kidney disease as a potent predictor of cardiovascular disease and its complications.

Randomized trials should be performed to determine whether modification of traditional and nontraditional risk factors can reduce incident cardiovascular disease as well as which interventions can optimize treatment outcomes in persons with chronic kidney disease and cardiovascular disease.

[MeSH-major] Cardiovascular Diseases / epidemiology. Kidney Diseases / epidemiology

[MeSH-minor] Chronic Disease. Glomerular Filtration Rate. Humans. Renal Dialysis. Risk Factors

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(PMID = 16609298.001).

[ISSN] 1062-4821

[Journal-full-title] Current opinion in nephrology and hypertension

[ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Number-of-references] 67

   

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[Title] Medication adherence in successful kidney transplant recipients.

OBJECTIVE: To explore the medication-taking behavior of successful kidney transplant recipients and determine what behaviors were common among this group.

METHODS: Open-ended interviews were conducted by telephone with 19 individuals who had successfully maintained a transplanted kidney for 25 years or more.

RESULTS: Four themes emerged as participants described the behaviors they developed to adhere successfully to the immunosuppressive medication required for maintaining their transplanted kidneys.

Kidney transplant recipients identified the importance of developing and maintaining medication-taking skills and routines on medication adherence.

CONCLUSIONS: Interventions focusing on medication-taking skills, habit formation, and resources for problem solving may improve immunosuppressive medication adherence and clinical outcomes in kidney transplant recipients.

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[Cites] Transplantation. 2000 Oct 27;70(8):1240-4 [11063348.001]

[Cites] Circulation. 2008 Jan 29;117(4):e25-146 [18086926.001]

[Cites] Clin Transplant. 2001 Oct;15(5):330-6 [11678959.001]

[Cites] Transplant Proc. 2003 Mar;35(2):796-7 [12644142.001]

[Cites] J Healthc Qual. 2003 Mar-Apr;25(2):20-5 [12659076.001]

[Cites] Clin Nurse Spec. 2003 Jul;17(4):200-8; quiz 209-30 [12869867.001]

[Cites] Am J Hosp Pharm. 1979 Oct;36(10):1321-5 [507073.001]

[Cites] Transplantation. 1995 Feb 15;59(3):340-7 [7871562.001]

[Cites] Clin Transplant. 1997 Dec;11(6):618-22 [9408696.001]

[Cites] J Heart Lung Transplant. 1998 Sep;17(9):854-63 [9773856.001]

[Cites] Manag Care Interface. 2004 Sep;17(9):44-8 [15521285.001]

[Cites] Am J Transplant. 2007 Dec;7(12):2704-11 [17868065.001]

[Cites] Am J Kidney Dis. 2007 Feb;49(2):294-300 [17261432.001]

[Cites] Clin Transplant. 2006 May-Jun;20(3):359-68 [16824155.001]

[Cites] Acta Gastroenterol Belg. 2005 Jul-Sep;68(3):347-52 [16268422.001]

[Cites] Kidney Int. 2001 Oct;60(4):1565-70 [11576374.001]

(PMID = 19588667.001).

[ISSN] 1526-9248

[Journal-full-title] Progress in transplantation (Aliso Viejo, Calif.)

[ISO-abbreviation] Prog Transplant

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / U24 CA092656; United States / NCI NIH HHS / CA / R24 CA092656; United States / NINR NIH HHS / NR / P30 NR003979; United States / NINR NIH HHS / NR / P30 NR003979-15; None / None / / P30 NR003979-15

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Immunosuppressive Agents

[Other-IDs] NLM/ NIHMS266536; NLM/ PMC3071038

   

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[Title] Peritransplant immunoadsorption: a strategy enabling transplantation in highly sensitized crossmatch-positive cadaveric kidney allograft recipients.

BACKGROUND: Kidney transplant recipients with a current positive complement-dependent cytotoxicity crossmatch (CDCXM) are at high risk for hyperacute rejection and graft loss.

In this analysis, we evaluated effectiveness of peritransplant IA as an anti-humoral strategy to overcome a current positive CDCXM in presensitized renal allograft recipients.

METHODS: Between 1999 and 2003, 40 high risk cadaveric kidney allograft recipients (median CDC panel reactive antibody [PRA] level, 77%; number of retransplants, n = 38) were subjected to peritransplant IA with protein A (one pretransplant IA session followed by a course of repeat posttransplant IA sessions) in addition to preemptive antilymphocyte antibody therapy.

CONCLUSION: Our results demonstrate that peritransplant IA enables successful cadaveric kidney transplantation in the context of a positive CDCXM.

[MeSH-major] Graft Survival / immunology. Histocompatibility Testing. Immunosorbents / immunology. Kidney Transplantation / immunology

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(PMID = 15785376.001).

[ISSN] 0041-1337

[Journal-full-title] Transplantation

[ISO-abbreviation] Transplantation

[Language] eng

[Publication-type] Clinical Trial; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Immunosorbents

   

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[Title] Dysplastic kidney and not renal agenesis is the commonly associated anomaly in infants with seminal vesicle cyst.

OBJECTIVE: To determine whether the association of seminal vesicle cyst (SVC) and renal anomaly in young children correlates with previously reported cases of SVCs in adolescent and adult patients, as congenital SVCs, although rare, are frequently described in association with ipsilateral renal agenesis, mainly in adolescent and adult patients, whereas reports on SVCs in younger children are sparse.

PATIENTS AND METHODS: We report on nine infants (median age 4 months) with congenital SVCs, all of them associated with ipsilateral dysplastic kidneys.

All patients had ultrasonography of the renal system and voiding cysto-urethrography.

RESULTS: The SVCs were found incidentally during ultrasonography for the renal anomaly.

Three patients had dysplastic and six had multicystic dysplastic kidneys.

In previous reported adult cases of SVCs the most common associated renal anomaly was agenesis of the ipsilateral kidney (25 of 44 cases), whereas only one case of dysplastic kidney was reported.

CONCLUSION: As the appearance of renal agenesis might result from a former congenital dysplastic kidney, our findings indicate that cases of ipsilateral renal agenesis in adult patients with congenital SVCs might represent former dysplastic or multicystic dysplastic kidney.

[MeSH-major] Cysts / etiology. Genital Diseases, Male / etiology. Kidney / abnormalities. Multicystic Dysplastic Kidney / complications. Seminal Vesicles

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(PMID = 19040535.001).

[ISSN] 1464-410X

[Journal-full-title] BJU international

[ISO-abbreviation] BJU Int.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Multiple high-intensity focused ultrasound probes for kidney-tissue ablation.

BACKGROUND AND PURPOSE: To investigate kidney-tissue ablation by high-intensity focused ultrasound (HIFU) using multiple and single probes.

MATERIALS AND METHODS: Ultrasound beams (1.75 MHz) produced by a piezoceramic element (focal distance 80 mm) were focused at the center of renal parenchyma.

Lesion dimensions were examined in perfused and unperfused ex vivo porcine kidneys at different power levels (40, 60, and 80 W) and treatment times (4, 6, and 8 seconds).

Lesions in perfused kidneys were smaller than those in unperfused kidneys.

CONCLUSIONS: Ex vivo, kidney-tissue ablation by means of multiple HIFU probes offers significant advantages over single HIFU probes in respect of lesion size and formation.

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(PMID = 16253077.001).

[ISSN] 0892-7790

[Journal-full-title] Journal of endourology

[ISO-abbreviation] J. Endourol.

[Language] ENG

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] [Lymphocele and kidney transplantation].

INTRODUCTION: Lymphocele is a special complication following kidney transplantation.

The authors examined the factors associated with an increased occurrence of clinically significant perinephric fluid collections and/or lymphoceles among sirolimus-treated renal transplant recipients.

In both subgroups the serum creatinine levels were elevated at the time of diagnosis from a nadir of 179.5 +/- 141.7 to 359.9 +/- 259.6 mmol/l (Group III, sirolimus treated) and from 222.6 +/- 205.9 to 383.7 +/- 255.2 mmol/l (Group IV, sirolimus free).

Despite an Influenza A + Chlamydia pneumonia and acute rejection which was followed by a GI bleeding and stomach resection he fully recovered and is doing well with an excellent kidney function a year after.

[MeSH-major] Immunosuppressive Agents / adverse effects. Kidney Transplantation / adverse effects. Lymphocele / etiology

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(PMID = 17656338.001).

[ISSN] 0030-6002

[Journal-full-title] Orvosi hetilap

[ISO-abbreviation] Orv Hetil

[Language] hun

[Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article

[Publication-country] Hungary

[Chemical-registry-number] 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine; MRK240IY2L / Azathioprine; VB0R961HZT / Prednisone; W36ZG6FT64 / Sirolimus

   

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[Title] Acidosis and progression of chronic kidney disease.

PURPOSE OF REVIEW: Chronic kidney disease progressively impairs the ability of kidneys to excrete hydrogen ions owing to the reduced capacity of the kidney to synthesize ammonia resulting in metabolic acidosis.

There is good experimental evidence that metabolic acidosis contributes to protein energy wasting disorder and progression of chronic kidney disease (CKD).

RECENT FINDINGS: Three recent publications have confirmed the experimental evidence and the only randomized controlled study of its kind has suggested that the correction of acidosis by sodium bicarbonate in patients with advanced CKD is associated with attenuation of the rate of decline of renal function, reduction in the incidence of end stage renal disease and improvement of nutritional parameters.

SUMMARY: In light of these recent studies, it appears that this cheap and simple strategy, which is in line with current renal recommendations, has the potential of translating into significant economic, quality of life and clinical outcome benefits in an expanding pool of patients with CKD.

[MeSH-major] Acidosis / complications. Kidney Diseases / complications

[MeSH-minor] Animals. Disease Progression. Glomerular Filtration Rate. Humans. Kidney / physiopathology

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(PMID = 20539229.001).

[ISSN] 1473-6543

[Journal-full-title] Current opinion in nephrology and hypertension

[ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

   

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[Title] Epithelial-mesenchymal-epithelial cycling in kidney repair.

PURPOSE OF REVIEW: Tubule repair following acute kidney injury involves epithelial de-differentiation followed by cell migration and proliferation and eventual re-differentiation.

RECENT FINDINGS: Epithelial de-differentiation after kidney injury or in epithelial culture systems is controlled by secreted factors such as transforming growth factor beta and hepatocyte growth factor as well as cell-cell and cell-matrix interactions.

SUMMARY: This review focuses on the underlying molecular mechanism of epithelial de-differentiation and re-differentiation in tubule repair in vivo and formation in vitro, thus giving insight into possible strategies for improving recovery following acute kidney injury and preventing progression to chronic kidney disease.

[MeSH-major] Epithelium / physiology. Kidney / physiology. Mesoderm / physiology

[MeSH-minor] Animals. Cell Differentiation / physiology. Humans. Kidney Diseases / pathology. Kidney Diseases / physiopathology. Kidney Tubules / growth & development. Kidney Tubules / physiology. Wnt Proteins / metabolism

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(PMID = 18660674.001).

[ISSN] 1062-4821

[Journal-full-title] Current opinion in nephrology and hypertension

[ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 0 / Wnt Proteins

[Number-of-references] 58

   

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[Title] Education for patients with chronic kidney disease in Taiwan: a prospective repeated measures study.

AIM: To investigate the physical, knowledge and quality of life outcomes of an educational intervention for patients with early stage chronic kidney disease.

BACKGROUND: A comprehensive predialysis education care team can be effective in slowing the progression of chronic kidney disease.

A predialysis, team-delivered educational intervention covering renal function health care, dietary management of renal function and the effects of Chinese herb medication on renal function was designed and implemented.

Study outcomes included physical indicators, knowledge (renal function protection, use of Chinese herbs and renal function and diet) and quality of life.

The primary indicator of renal function, glomerular filtration rate, remained stable throughout the 12 months of follow-up, despite the relatively older mean age of study participants.

CONCLUSION: A predialysis education care team can provide effective disease-specific knowledge and may help retard deterioration of renal function in persons with early-stage chronic kidney disease.

[MeSH-major] Kidney Diseases / physiopathology. Patient Education as Topic

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(PMID = 19012761.001).

[ISSN] 1365-2702

[Journal-full-title] Journal of clinical nursing

[ISO-abbreviation] J Clin Nurs

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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[Title] Evidence-based management of patients undergoing PCI: contrast-induced acute kidney injury.

Contrast-induced acute kidney injury (CI-AKI) is one of the leading causes of hospital-acquired acute kidney injury.

CI-AKI is highly prevalent in patients with well-known risk factors, including older age, chronic renal insufficiency, congestive heart failure, and diabetes.

[MeSH-major] Angioplasty, Balloon, Coronary. Contrast Media / adverse effects. Kidney Diseases / prevention & control. Radiography, Interventional / adverse effects

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[Copyright] (c) 2010 Wiley-Liss, Inc.

(PMID = 20333702.001).

[ISSN] 1522-726X

[Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

[ISO-abbreviation] Catheter Cardiovasc Interv

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Contrast Media; 0 / Protective Agents; 8MDF5V39QO / Sodium Bicarbonate; INU8H2KAWG / Fenoldopam; VTD58H1Z2X / Dopamine; WYQ7N0BPYC / Acetylcysteine

[Number-of-references] 47

   

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[Title] Effect of polyphenol-containing azuki bean (Vigna angularis) extract on blood pressure elevation and macrophage infiltration in the heart and kidney of spontaneously hypertensive rats.

1. Hypertension is a major risk factor for myocardial infarction and renal damage, and it has also been shown to have pro-inflammatory actions that increase the formation of reactive oxygen species.

Therefore, the aim of the present study was to investigate the effect of polyphenol-containing azuki bean extract (ABE) on systolic blood pressure (SBP) and macrophage infiltration in the heart and kidney of spontaneously hypertensive rats (SHR).

Tail SBP and macrophage kinetics in the heart and kidney were examined.

4. Nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated superoxide (O2-) production was enhanced in the kidney and heart in SHR and WKY rats compared with levels in the absence of NADH or NADPH.

The NADPH-stimulated superoxide (O2-) levels in the kidney in untreated SHR was significantly higher than that in untreated WKY rats.

5. In immunohistochemical analyses, the number of macrophages in the heart and in the glomeruli and tubulointerstitium of the kidney was significantly higher in ABE-untreated SHR than in ABE-untreated WKY rats.

There were significant positive correlations between SBP and the number of ED1-positive macrophages in the heart and tubulointerstitial and glomerular areas of the kidney in WKY rats and SHR.

6. In conclusion, the results of the present study suggest that ABE attenuates the elevation of SBP and macrophage infiltration in the heart, as well as in the glomeruli and tubulointerstitium of the kidney, in our SHR model.

[MeSH-major] Antihypertensive Agents / pharmacology. Blood Pressure / drug effects. Fabaceae. Flavonoids / pharmacology. Heart / drug effects. Hypertension / drug therapy. Kidney / drug effects. Macrophages / drug effects. Phenols / pharmacology

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(PMID = 18047626.001).

[ISSN] 1440-1681

[Journal-full-title] Clinical and experimental pharmacology & physiology

[ISO-abbreviation] Clin. Exp. Pharmacol. Physiol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Australia

[Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Flavonoids; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols; 0 / Thiobarbituric Acid Reactive Substances; 0U46U6E8UK / NAD; 11062-77-4 / Superoxides

   

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[Title] The role of vitamin D receptor activation in chronic kidney disease.

Observational data indicate that there is a close inter-relationship between progressive renal dysfunction in patients with chronic kidney disease cardiovascular disease and mortality.

Continuously evidence indicates that deficiencies in vitamin D receptor activation represents one of key players in adversely affecting cardiovascular health, as well as inducing to secondary hyperparathyroidism in chromic kidney disease patients.

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[Cites] J Am Soc Nephrol. 1998 Aug;9(8):1427-32 [9697664.001]

[Cites] Contrib Nephrol. 2009;163:213-8 [19494616.001]

[Cites] N Engl J Med. 2004 Sep 23;351(13):1296-305 [15385656.001]

[Cites] J Am Soc Nephrol. 2005 Apr;16(4):1115-25 [15728786.001]

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(PMID = 20411052.001).

[ISSN] 1790-8019

[Journal-full-title] Hippokratia

[ISO-abbreviation] Hippokratia

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Other-IDs] NLM/ PMC2843577

[Keywords] NOTNLM ; cardiovascular disease / haemodialysis / vitamin D

   

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[Title] The prohibition of kidney sales and organ markets should remain.

RECENT FINDINGS: In 'natural experiments' performed in developing countries the outcome for kidney vendors, in terms of both their medical and psychosocial health, has been shown to be poor.

SUMMARY: Commercialization of living kidney donation does not serve the interests of the donors, endangers the health of recipients, and undermines the healthy development of the international transplant endeavor.

[MeSH-major] Financing, Organized / legislation & jurisprudence. Government Regulation. Health Policy / economics. Kidney Transplantation / economics. Living Donors / legislation & jurisprudence. Tissue and Organ Procurement / economics

[MeSH-minor] Altruism. Cost-Benefit Analysis. Crime / prevention & control. Gift Giving. Health Care Costs. Health Services Accessibility / economics. Health Services Accessibility / legislation & jurisprudence. Health Services Needs and Demand / economics. Health Services Needs and Demand / legislation & jurisprudence. Humans. Motivation. Organizational Objectives. Public Opinion. Renal Dialysis / economics. Risk Assessment. United States. Waiting Lists

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(PMID = 18685334.001).

[ISSN] 1531-7013

[Journal-full-title] Current opinion in organ transplantation

[ISO-abbreviation] Curr Opin Organ Transplant

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 37

   

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[Title] SCreening for Occult REnal Disease (SCORED): a simple prediction model for chronic kidney disease.

BACKGROUND: Despite the wide availability and low cost of serum creatinine measurement, at-risk populations are not routinely tested for chronic kidney disease (CKD).

METHODS: We used a cross-sectional analysis of a nationally representative, population-based survey to develop a system, SCORED (SCreening for Occult REnal Disease), that uses routinely available demographic and medical information to identify individuals with an increased likelihood of CKD.

Chronic kidney disease was defined as a glomerular filtration rate less than 60 mL/min per 1.73 m(2).

CONCLUSION: This scoring system, weighted toward common variables associated with CKD, may be a useful tool to identify individuals with a high likelihood of occult kidney disease.

[MeSH-major] Creatinine / blood. Kidney Failure, Chronic / diagnosis. Mass Screening / methods. Models, Biological. Population Surveillance

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(PMID = 17325299.001).

[ISSN] 0003-9926

[Journal-full-title] Archives of internal medicine

[ISO-abbreviation] Arch. Intern. Med.

[Language] eng

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] AYI8EX34EU / Creatinine

   

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[Title] Cyclosporine lymphocyte maximum level monitoring in de novo kidney transplant patients: a prospective study.

OBJECTIVES: To determine prospectively the temporal variations of cyclosporine-A lymphocyte maximum level, whole blood maximum concentration, and total lymphocyte count in patients with de novo kidney transplantation.

MATERIALS AND METHODS: Lymphocyte maximum level, whole blood maximum concentration, and total lymphocyte count were prospectively measured in 35 patients at 1, 2, and 3 months after kidney transplantation.

Cyclosporine-A lymphocyte maximum level seems to offer a more reliable alternative than does whole blood maximum concentration for cyclosporine-A monitoring in patients with kidney transplantation.

[MeSH-major] Cyclosporine / blood. Immunosuppressive Agents / blood. Kidney Transplantation. Lymphocytes / metabolism

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(PMID = 16827634.001).

[ISSN] 1304-0855

[Journal-full-title] Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

[ISO-abbreviation] Exp Clin Transplant

[Language] eng

[Publication-type] Journal Article

[Publication-country] Turkey

[Chemical-registry-number] 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine

   

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[Title] Social participation after successful kidney transplantation.

PURPOSE: To explore and describe the degree of social participation after kidney transplantation and to examine associated factors.

METHOD: A cross-sectional study on 239 adult patients 1-7.3 years after kidney transplantation was performed via in-home interviews on participation in obligatory activities (i.e., employment, education, household tasks) and leisure activities (volunteer work, assisting others, recreation, sports, clubs/associations, socializing, going out).

RESULTS: Kidney transplantation patients had a lower educational level, spent less time on obligatory activities, had part-time jobs more often, and participated less in sports compared to a control group from the general population.

CONCLUSIONS: Although kidney transplantation patients participate less in employment and sports, they do participate in household tasks, volunteer work, going out, socializing and other leisure activities.

[MeSH-major] Activities of Daily Living. Employment. Interpersonal Relations. Kidney Transplantation. Leisure Activities

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(PMID = 17364802.001).

[ISSN] 0963-8288

[Journal-full-title] Disability and rehabilitation

[ISO-abbreviation] Disabil Rehabil

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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[Title] Hereditary hypophosphatemias: new genes in the bone-kidney axis.

Hypophosphatemia due to isolated renal phosphate wasting is a genetically heterogeneous disease.

Hereditary hypophosphatemic rickets with hypercalciuria is another rare disorder of autosomal recessive inheritance.

The disease was mapped to a 1.6 Mbp region on chromosome 9q34, which contains SLC34A3, the gene encoding the renal sodium-phosphate cotransporter NaPi-IIc.

Thus, DMP1 and NaPi-IIc add two new members to the bone-kidney axis proposed since it was discovered that the first phosphatonin, FGF23, was of osteoblastic/osteocyte origin.

This provides a mechanism for the skeleton to communicate with the kidney to coordinate the mineralization of extracelular matrix and the renal handling of phosphate.

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(PMID = 17635744.001).

[ISSN] 1320-5358

[Journal-full-title] Nephrology (Carlton, Vic.)

[ISO-abbreviation] Nephrology (Carlton)

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Australia

[Chemical-registry-number] 0 / DMP1 protein, human; 0 / Extracellular Matrix Proteins; 0 / Phosphoproteins; 0 / SLC34A3 protein, human; 0 / Sodium-Phosphate Cotransporter Proteins, Type IIc

[Number-of-references] 22

   

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[Title] Improving on-line information for potential living kidney donors.

Individuals who consider becoming living kidney donors often search the internet for reliable information before contacting the transplant center.

Eighty-six unique websites on living kidney donation were found.

[MeSH-major] Information Dissemination. Internet. Kidney Transplantation. Living Donors

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(PMID = 17361119.001).

[ISSN] 0085-2538

[Journal-full-title] Kidney international

[ISO-abbreviation] Kidney Int.

[Language] eng

[Grant] United States / NIDDK NIH HHS / DK / K23-DK064689

[Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] [Bilateral angiomyolipoma of the kidney in patient with tuberous sclerosis].

Angiomyolipomas are relatively frequent tumours of the kidney.

It is believed that about 10 million people worldwide have such a tumour.

Due to the benign nature of angiomyolipomas, surgical treatment and embolisation of the tumours are generally not recommended, unless renal function is endangered, the symptoms are severe, or the kidney in question becomes completely dysfunctional.

We present a 24-year-old woman with tuberous sclerosis in whom bilateral kidney tumours were diagnosed 7 years earlier and in whom we carried out a left nephrectomy of a 5300 gram angiomyolipoma, which caused pain and complete loss of function.

Although tumourous, the right kidney was functional, so it was left untouched.

After an uneventful recovery, a close follow-up was recommended, as well as HLA typing, as it is highly probable that the right kidney will gradually become inadequate or completely dysfunctional, so that haemodialysis and/or kidney transplantation along with nephrectomy will become necessary.

[MeSH-major] Angiomyolipoma / complications. Kidney Neoplasms / complications. Tuberous Sclerosis / complications

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(PMID = 16640189.001).

[ISSN] 0370-8179

[Journal-full-title] Srpski arhiv za celokupno lekarstvo

[ISO-abbreviation] Srp Arh Celok Lek

[Language] srp

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Serbia and Montenegro

   

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[Title] Renal cell carcinoma in a horseshoe kidney presenting as an acute, left sided varicocele.

We present a rare case of renal cell carcinoma (RCC) in a horseshoe kidney presenting as an acute left sided varicocele.

A left sided varicocele is a well-described presentation of RCC, usually caused by tumour thrombus extending along the renal vein with resultant testicular vein occlusion.

However, in our case a tumour in the lower pole of a horseshoe kidney caused an acute varicocele by direct involvement and occlusion of the testicular vein.

[MeSH-major] Carcinoma, Renal Cell / complications. Kidney / abnormalities. Kidney Neoplasms / complications. Varicocele / etiology

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[Cites] Eur Urol. 1998;33(2):175-9 [9519360.001]

[Cites] Urology. 1976 Aug;8(2):146-8 [960345.001]

(PMID = 16835726.001).

[ISSN] 0301-1623

[Journal-full-title] International urology and nephrology

[ISO-abbreviation] Int Urol Nephrol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Netherlands

   

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[Title] Hypertension management in patients with chronic kidney disease.

Hypertension is one of the major risk factors for the development and progression of chronic kidney disease.

The loss of renal function leads to impaired renal autoregulation and renders the kidney vulnerable to the damaging effects of uncontrolled hypertension.

Mounting evidence indicates that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers slow the progression of chronic kidney disease through effects beyond lowering blood pressure.

Studies are needed to determine whether high doses of the single agent or combination therapy is most effective in providing renal protection.

Urinary protein excretion is a useful tool for monitoring and titrating therapy to maximize renal protection.

Changes in the serum creatinine concentration and hyperkalemia are complications of antihypertensive therapy in patients with chronic kidney disease that can be successfully managed to allow continued use of renin-angiotensin blockade.

[MeSH-major] Hypertension / prevention & control. Renal Insufficiency, Chronic / etiology. Renal Insufficiency, Chronic / prevention & control

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(PMID = 18775113.001).

[ISSN] 1534-3111

[Journal-full-title] Current hypertension reports

[ISO-abbreviation] Curr. Hypertens. Rep.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Antihypertensive Agents; EC 3.4.23.15 / Renin

[Number-of-references] 40

   

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[Title] [Management of anemia in chronic kidney disease].

[Transliterated title] Manejo de la anemia en la enfermedad renal cronica.

1. All patients with anemia secondary to CKD should be treated and evaluated for possible treatment, irrespective of underlying disease, associated comorbidity or possibility of kidney replacement therapy.

Normalization of Hb levels in CKD is associated with an improvement in health-related quality of life, but without differences in mortality or the rate of loss of kidney function (Strength of Recommendation A).

[MeSH-major] Anemia / drug therapy. Anemia / etiology. Kidney Diseases / complications

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(PMID = 19018741.001).

[ISSN] 0211-6995

[Journal-full-title] Nefrología : publicación oficial de la Sociedad Española Nefrologia

[ISO-abbreviation] Nefrologia

[Language] spa

[Publication-type] English Abstract; Journal Article; Practice Guideline

[Publication-country] Spain

   

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[Title] [Metabolic acidosis after kidney transplantation].

Metabolic acidosis is a common complication in patients after kidney transplantation.

It is caused by inability of transplanted kidney to regenerate bicarbonate buffer.

Although every type of acidosis may be present in these patients, the most frequent are renal tubular acidosis and uremic acidosis.

Ketoacidosis due to a post-transplant diabetes mellitus and bicarbonate loss in patients after simultaneous pancreas/kidney transplantation are rarely observed.

The proper diagnosis and appropriate treatment with oral supplements are essential.

[MeSH-major] Acidosis, Renal Tubular / metabolism. Kidney Transplantation / adverse effects

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(PMID = 16053226.001).

[ISSN] 0033-2240

[Journal-full-title] Przegla̧d lekarski

[ISO-abbreviation] Prz. Lek.

[Language] pol

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Poland

[Chemical-registry-number] 0 / Bicarbonates

[Number-of-references] 28

   

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[Title] Long-term effects of extracorporeal shock wave lithotripsy on renal function: our experience with 156 patients with solitary kidney.

PURPOSE: We studied the long-term impact of shock wave lithotripsy on renal function, stone recurrence and hypertension in patients with a solitary kidney.

Patients with a solitary kidney provide a unique opportunity to evaluate any clinically significant change in renal function.

MATERIALS AND METHODS: We retrospectively reviewed the records of 156 patients with stones in a solitary kidney treated with shock wave lithotripsy monotherapy.

Serum creatinine, systolic and diastolic blood pressure, new onset hypertension, calculated glomerular filtration rate, and kidney morphology were determined before and after treatment, and compared by chi-square, paired and unpaired t tests.

Renal obstruction caused by steinstrasse after shock wave lithotripsy occurred in 14 (8.9%) patients.

CONCLUSIONS: The demonstrated effectiveness, small number of complications at short-term followup, insignificant effect on renal function, blood pressure and relatively small number of recurrences at the long-term followup confirm that shock wave lithotripsy is not only effective but is also safe in the long run.

[MeSH-major] Kidney / abnormalities. Kidney / physiopathology. Kidney Calculi / physiopathology. Kidney Calculi / therapy. Kidney Failure, Chronic

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(PMID = 18423733.001).

[ISSN] 1527-3792

[Journal-full-title] The Journal of urology

[ISO-abbreviation] J. Urol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Prevalence of urogenital mycoplasmas and ureaplasmas in women after kidney transplantation.

BACKGROUND: The prevalence of urogenital mycoplasmas and ureaplasmas in kidney transplant and hemodialyzed patients was studied.

CONCLUSION: Our observation showed the necessity of careful examination of possible atypical pathogens in diagnostic materials from hemodialyzed and kidney transplant patients.

[MeSH-major] Female Urogenital Diseases / epidemiology. Kidney Transplantation / adverse effects. Mycoplasma Infections / epidemiology. Postoperative Complications / microbiology. Ureaplasma Infections / epidemiology

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(PMID = 19300187.001).

[ISSN] 1534-6080

[Journal-full-title] Transplantation

[ISO-abbreviation] Transplantation

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Secretory and cytosolic (pro)renin in kidney, heart, and adrenal gland.

Renin is commonly known as a secretory glycoprotein, which is expressed, stored, and secreted in a regulated manner by the kidney.

The rat kidney exclusively expresses secretory renin.

[MeSH-major] Adrenal Glands / metabolism. Cytosol / metabolism. Kidney / metabolism. Myocardium / metabolism. Renin / metabolism

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[Cites] Am J Physiol. 1992 Feb;262(2 Pt 1):E224-9 [1539649.001]

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(PMID = 18368380.001).

[ISSN] 0946-2716

[Journal-full-title] Journal of molecular medicine (Berlin, Germany)

[ISO-abbreviation] J. Mol. Med.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] Germany

[Chemical-registry-number] EC 3.4.23.15 / Renin

[Number-of-references] 30

   

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[Title] Role of crystal surface adhesion in kidney stone disease.

These studies have produced new insight into the specific chemical interactions that regulate kidney stone formation.

SUMMARY: The low adhesion force for calcium oxalate dihydrate predicts a decreased ability of these crystals to aggregate or attach to cells, and correlates with the relative absence of calcium oxalate dihydrate in kidney stones.

[MeSH-major] Calcium Oxalate / chemistry. Kidney Calculi / chemistry

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(PMID = 16775453.001).

[ISSN] 1062-4821

[Journal-full-title] Current opinion in nephrology and hypertension

[ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 2612HC57YE / Calcium Oxalate

[Number-of-references] 51

   

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[Title] Scarless single-port laparoscopic pelvic kidney nephrectomy.

INTRODUCTION: We report the first pelvic kidney removal through the umbilicus using a scarless pure single-port technique in a young woman.

PATIENTS AND METHODS: A 27-year-old woman presented with uro-sepsis and acute renal failure secondary to a dilated, chronically infected, nonfunctioning left-sided pelvic kidney with ureteropelvic obstruction causing an obstruction to the right kidney.

Definitive treatment involved removal of the diseased pelvic kidney through the umbilicus via a single-port access device (TriPor™; Olympus).

[MeSH-major] Acute Kidney Injury / surgery. Kidney Pelvis / surgery. Laparoscopy / methods. Nephrectomy / methods. Ureteral Obstruction / surgery

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(PMID = 20874248.001).

[ISSN] 1557-9034

[Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A

[ISO-abbreviation] J Laparoendosc Adv Surg Tech A

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Wait list death and survival benefit of kidney transplantation among nonrenal transplant recipients.

The disparity between the number of patients waiting for kidney transplantation and the limited supply of kidney allografts has renewed interest in the benefit from kidney transplantation experienced by different groups.

This study evaluated kidney transplant survival benefit in prior nonrenal transplant recipients (kidney after liver, KALi; lung, KALu; heart, KAH) compared to primary isolated (KA1) or repeat isolated kidney (KA2) transplant.

Following kidney transplant, patient survival was greatest for KA1, similar among KA2, KALi, KAH, and inferior for KALu.

Compared to the entire wait list, renal transplantation was associated with a survival benefit among all groups except KALu (p = 0.017; HR = 1.61; CI = 1.09-2.38), where posttransplant survival was inferior to the wait list population.

Recipients of KA1 kidney transplantation have the greatest posttransplant survival and compared to the overall kidney wait list, the greatest survival benefit.

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[Copyright] ©2010 The Authors Journal compilation©2010 The American Society of Transplantation and the American Society of Transplant Surgeons.

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(PMID = 20977641.001).

[ISSN] 1600-6143

[Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

[ISO-abbreviation] Am. J. Transplant.

[Language] ENG

[Grant] United States / NIDDK NIH HHS / DK / K23 DK078688; United States / NIDDK NIH HHS / DK / K23 DK078688-01

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Other-IDs] NLM/ NIHMS235283; NLM/ PMC2966021

   

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[Title] Expression of epidermal growth factor in the developing rat kidney.

Epidermal growth factor (EGF) is important in mammalian renal development.

In our study, we investigated the detailed distribution and the time of the first appearance of EGF in developing rat kidney.

Kidneys from embryonic 18 (E18)- and 20-day-old (E20) fetuses, postnatal 1 (P1)-, 3 (P3)-, 7 (P7)-, 14 (P14)-, and 21-day-old (P21) pups, and adults were processed for immunohistochemistry and electronmicroscopy.

In adult rat kidney, EGF immunoreactivity was found in distal tubule including the thick ascending limb (TAL) and portion 1 of distal convoluted tubule (DCT1), whereas no EGF immunoreactivity was seen in portion 2 of distal convoluted tubule (DCT2) and connecting tubule.

In developing kidney, EGF-positive cells first appeared at P3 and were localized in the middle portion of the differentiating TAL of the corticomedullary junction.

However, EGF-positive and EGF-negative cells were in the TAL in developing rat kidney.

Our results suggest that the expression of EGF in developing kidney plays an important role in the regulation of growth and differentiation of the loop of Henle during kidney development and that this may act in the paracrine mode.

[MeSH-major] Epidermal Growth Factor / biosynthesis. Gene Expression Regulation, Developmental / physiology. Kidney / growth & development

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(PMID = 15353402.001).

[ISSN] 1931-857X

[Journal-full-title] American journal of physiology. Renal physiology

[ISO-abbreviation] Am. J. Physiol. Renal Physiol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 62229-50-9 / Epidermal Growth Factor; G34N38R2N1 / Bromodeoxyuridine

   

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[Title] Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection.

Currently, there is an unmet clinical need for novel immunosuppressive agents for long-term prevention of kidney transplant rejection as alternatives to the nephrotoxic calcineurin inhibitor cyclosporine (CsA).

We investigated whether combined blockade of the T-cell K(+) channels K(Ca)3.1 and K(v)1.3, both of which regulate calcium signaling during lymphocyte activation, is effective in prevention of rejection of kidney allografts from Fisher rats to Lewis rats.

Kidney sections were stained with periodic acid-Schiff or hematoxylin-eosin and histochemically for markers of macrophages (CD68), T-lymphocytes (CD43), or cytotoxic T-cells (CD8).

Thus, selective blockade of T-lymphocyte K(Ca)3.1 and K(v)1.3 channels may represent a novel alternative therapy for prevention of kidney allograft rejection.

[MeSH-major] Graft Rejection / prevention & control. Immunosuppression / methods. Intermediate-Conductance Calcium-Activated Potassium Channels / immunology. Kidney Transplantation / immunology. Kv1.1 Potassium Channel / immunology. T-Lymphocytes / immunology

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[Cites] Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6 [10884437.001]

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(PMID = 19715983.001).

[ISSN] 1873-2623

[Journal-full-title] Transplantation proceedings

[ISO-abbreviation] Transplant. Proc.

[Language] eng

[Grant] United States / NIGMS NIH HHS / GM / R01 GM076063; United States / NIGMS NIH HHS / GM / R01 GM076063; United States / NIGMS NIH HHS / GM / R01 GM076063-04

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Cnidarian Venoms; 0 / Intermediate-Conductance Calcium-Activated Potassium Channels; 0 / Kcnn4 protein, rat; 0 / Pyrazoles; 0 / ShK neurotoxin; 0 / TRAM 34; 147173-20-4 / Kv1.1 Potassium Channel

[Other-IDs] NLM/ NIHMS370561; NLM/ PMC3343637

   

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[Title] Non-HLA T-cell reactivity during the first year after HLA-identical living-related kidney transplantation.

We wondered whether donor-reactive T-cell responses directed to minor histocompatibility antigens (mHAgs) or other non-HLA antigens also decrease after HLA-identical living-related (LR) kidney transplantation.

METHODS: We studied donor-reactive T-cell responses by IFN-gamma and granzyme B (GrB) Elispot assays in 15 HLA-identical LR kidney transplant recipients before, six months and one yr after transplantation.

CONCLUSIONS: Donor-reactivity could be detected before and after HLA-identical LR kidney transplantation, but was not related with the number of mHAg mismatches, and did not decrease after transplantation.

[MeSH-major] Graft Rejection / immunology. HLA Antigens / immunology. Kidney Transplantation / immunology. Minor Histocompatibility Antigens / immunology. T-Lymphocytes / immunology

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(PMID = 19563488.001).

[ISSN] 1399-0012

[Journal-full-title] Clinical transplantation

[ISO-abbreviation] Clin Transplant

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Denmark

[Chemical-registry-number] 0 / HLA Antigens; 0 / Minor Histocompatibility Antigens; 82115-62-6 / Interferon-gamma; EC 3.4.21.- / GZMB protein, human; EC 3.4.21.- / Granzymes

   

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[Title] A systematic review on steroid withdrawal between 3 and 6 months after kidney transplantation.

BACKGROUND: Steroid withdrawal (SW) after the first posttransplant months in patients receiving a kidney transplant has been recently discouraged in clinical guidelines.

METHODS: A systematic review and meta-analysis of randomized controlled trials assessing SW (beyond the second week after kidney transplantation) was performed.

CONCLUSIONS: SW after 3 to 6 months of kidney transplantation is associated with increased rates of acute rejection only if CsA is used but not with tacrolimus.

[MeSH-major] Adrenal Cortex Hormones / administration & dosage. Kidney Transplantation / immunology

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[CommentIn] Transplantation. 2010 Aug 27;90(4):350-2 [20548264.001]

[CommentIn] Transplantation. 2011 Mar 15;91(5):e27-8 [21336084.001]

[CommentIn] Transplantation. 2011 Mar 15;91(5):e25; author reply e26-7 [21336081.001]

(PMID = 20574419.001).

[ISSN] 1534-6080

[Journal-full-title] Transplantation

[ISO-abbreviation] Transplantation

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine

[Number-of-references] 23

   

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[Title] Successful simultaneous kidney-pancreas transplantation from extreme donors.

RESULTS: From January 2002 through January 2005, we performed 40 simultaneous kidney-pancreas transplants (SKPT) with Thymoglobulin induction, including 9 (22.5%) from EX and 31 from CONV DDs.

With a mean follow-up of 16.8 months in the EX DD group, patient and kidney graft survival rates are both 100%, and the pancreas graft survival rate is 89%.

With a mean follow-up of 21.7 months in the CONV DD group, patient and kidney graft survival rates are both 93.5% and the pancreas graft survival rate is 77.4%.

All patients with surviving grafts exhibited good initial (1 case of delayed kidney graft function in a CONV DD) and stable long-term kidney and pancreas graft function.

[MeSH-major] Antilymphocyte Serum / therapeutic use. Kidney Transplantation / physiology. Pancreas Transplantation / physiology. Tissue Donors / statistics & numerical data

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(PMID = 16298652.001).

[ISSN] 0041-1345

[Journal-full-title] Transplantation proceedings

[ISO-abbreviation] Transplant. Proc.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antilymphocyte Serum; 0 / Immunosuppressive Agents

   

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[Title] Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease.

Endothelin 1 is implicated in the development and progression of chronic kidney disease and associated cardiovascular disease.

We, therefore, studied the effects of selective endothelin-A receptor antagonism with BQ-123 on key independent surrogate markers of cardiovascular risk (blood pressure, proteinuria and renal hemodynamics, arterial stiffness, and endothelial function) in patients with nondiabetic chronic kidney disease.

In a double-blind, randomized crossover study, 22 subjects with proteinuric chronic kidney disease received, on 2 separate occasions, placebo or BQ-123.

Blood pressure, pulse wave velocity, flow-mediated dilation, renal blood flow, and glomerular filtration rate were monitored after drug dosing.

BQ-123 reduced blood pressure (mean arterial pressure: -7+/-1%; P<0.001 versus placebo) and increased renal blood flow (17+/-4%; P<0.01 versus placebo).

Nifedipine matched the blood pressure and renal blood flow changes seen with BQ-123.

Selective endothelin-A receptor antagonism reduced blood pressure, proteinuria, and arterial stiffness on top of standard treatment in renal patients.

If maintained longer term, selective endothelin-A receptor antagonism may confer cardiovascular and renal benefits in patients with chronic kidney disease.

[MeSH-major] Arteries / drug effects. Blood Pressure / drug effects. Kidney Failure, Chronic / drug therapy. Peptides, Cyclic / therapeutic use. Proteinuria / prevention & control

[MeSH-minor] Adult. Aged. Antihypertensive Agents / administration & dosage. Antihypertensive Agents / therapeutic use. Calcium Channel Blockers / administration & dosage. Calcium Channel Blockers / therapeutic use. Cross-Over Studies. Double-Blind Method. Endothelin Receptor Antagonists. Endothelin-1 / blood. Hemodynamics / drug effects. Hemodynamics / physiology. Humans. Middle Aged. Nifedipine / administration & dosage. Nifedipine / therapeutic use. Renal Circulation / drug effects. Sodium / urine. Treatment Outcome

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[CommentIn] Hypertension. 2009 Jul;54(1):29-31 [19506097.001]

(PMID = 19506099.001).

[ISSN] 1524-4563

[Journal-full-title] Hypertension (Dallas, Tex. : 1979)

[ISO-abbreviation] Hypertension

[Language] eng

[Grant] United Kingdom / British Heart Foundation / / PG/05/91

[Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Calcium Channel Blockers; 0 / Endothelin Receptor Antagonists; 0 / Endothelin-1; 0 / Peptides, Cyclic; 136553-81-6 / cyclo(Trp-Asp-Pro-Val-Leu); 9NEZ333N27 / Sodium; I9ZF7L6G2L / Nifedipine

   

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[Title] Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study examined the cross-sectional associations of serum phosphorus with ankle brachial index (ABI), pulse pressure, and large and small artery elasticity by radial artery waveform analysis among 1370 individuals (440 with moderate chronic kidney disease) who did not have clinical CVD and participated in the Multi-Ethnic Study of Atherosclerosis.

Participants with phosphorus levels >4 mg/dl had greater than four-fold risk for high ABI compared with participants with phosphate levels <3 mg/dl (relative risk 4.6; 95% confidence interval 1.6 to 13.2; P = 0.01) after adjustment for demographics, traditional CVD risk factors, and kidney function.

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(PMID = 19211667.001).

[ISSN] 1555-905X

[Journal-full-title] Clinical journal of the American Society of Nephrology : CJASN

[ISO-abbreviation] Clin J Am Soc Nephrol

[Language] ENG

[Grant] United States / NHLBI NIH HHS / HL / N01HC95169; United States / NHLBI NIH HHS / HC / N01-HC-95165; United States / NHLBI NIH HHS / HC / N01-HC-95169; United States / NHLBI NIH HHS / HL / N01HC95165; United States / NHLBI NIH HHS / HL / N01HC95159

[Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 27YLU75U4W / Phosphorus

[Other-IDs] NLM/ PMC2653665

   

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[Title] HBV reactivation after kidney transplantation.

In this study, we reviewed the virologic laboratory records from kidney recipients.

Out of 1512 patients, 228 had been diagnosed with resolved HBV infection (anti-HBc positive, HBsAg negative) but normal liver enzyme levels prior to kidney transplantation.

Reappearance of HBsAg after kidney transplantation was observed in two (0.9%) of those patients, which may be attributed to reactivation of a latent infection or to a new HBV infection.

Periodic follow-up of HBV serology for early diagnosis of reactivation is highly recommended in transplant recipients.

[MeSH-major] Hepatitis B / virology. Hepatitis B Surface Antigens / blood. Hepatitis B virus / physiology. Kidney Transplantation / adverse effects. Virus Activation

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(PMID = 15653420.001).

[ISSN] 1386-6532

[Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

[ISO-abbreviation] J. Clin. Virol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Hepatitis B Surface Antigens

   

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[Title] Pharmacodynamics of rituximab in kidney allotransplantation.

The anti-CD20 antibody rituximab has recently gained interest as a B-cell depleting agent in renal transplantation.

However, little is known about the pharmacodynamics of rituximab in renal transplant recipients.

We have therefore studied the effect of single-dose rituximab in combination with conventional triple immunosuppressive therapy on the B-cell population in peripheral blood as well as in tissues.

A total of 49 renal transplant recipients received single-dose rituximab, as induction therapy (n = 36) or as anti-rejection therapy (n = 13).

We counted B cells in peripheral blood and performed immunohistochemical staining on lymph nodes and kidney transplant tissue samples to assess the prevalence of B cells.

The immunohistochemical staining showed a complete elimination of B cells in kidney tissue and a reduction of B cells in lymph nodes.

In conclusion, single-dose rituximab in kidney transplant recipients evokes a long-term elimination of B cells in peripheral blood as well as within the kidney transplant.

[MeSH-major] Antibodies, Monoclonal / pharmacokinetics. Graft Rejection / drug therapy. Immunologic Factors / pharmacokinetics. Kidney Transplantation / pathology

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(PMID = 16925569.001).

[ISSN] 1600-6135

[Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

[ISO-abbreviation] Am. J. Transplant.

[Language] eng

[Databank-accession-numbers] ClinicalTrials.gov/ NCT00255593

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Denmark

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD19; 0 / Antigens, CD20; 0 / Immunologic Factors; 4F4X42SYQ6 / Rituximab

   

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[Title] BKV-infection in kidney graft dysfunction.

INTRODUCTION: BKV nephropathy (BKN) causes kidney graft loss, whose specific diagnosis is invasive and might be predicted by the early detection of active viral infection.

OBJECTIVE: Determine the BKV-infection prevalence in late kidney graft dysfunction by urinary decoy cell (DC) and viral DNA detection in urine (viruria) and blood (viremia; active infection).

METHODS: Kidney recipients with >1 month follow-up and creatinine >1.5 mg/dL and/or recent increasing >20% (n = 120) had their urine and blood tested for BKV by semi-nested PCR, DC searching, and graft biopsy.

Diagnosis efficacy of DC and viruria were compared to viremia.

Intense viruria was the single predictive test for active infection (3+; LR = 2.8).1,6-4,9 CONCLUSION: DC, BKV-viruria and -viremia are commun findings under late kidney graft dysfunction.

[MeSH-major] BK Virus / isolation & purification. Kidney Transplantation / adverse effects. Polyomavirus Infections / diagnosis. Primary Graft Dysfunction / virology. Tumor Virus Infections / diagnosis

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(PMID = 20563444.001).

[ISSN] 1678-4391

[Journal-full-title] The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

[ISO-abbreviation] Braz J Infect Dis

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Brazil

[Chemical-registry-number] 0 / DNA, Viral