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1. Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W: Giant-cell tumour of bone. The long-term results of treatment by curettage and bone graft. J Bone Joint Surg Br; 2004 Mar;86(2):212-6
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  • Giant-cell tumour of bone (GCT) is a locally benign aggressive tumour.
  • The use of adjuvant agents, such as phenol or liquid nitrogen has been recommended to destroy the remaining tumour cells after curettage, and filling of the defect with methylmethacrylate cement has been advocated.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Curettage / methods. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Antibiotic Prophylaxis / methods. Chlorides / therapeutic use. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Surgical Wound Infection / etiology. Treatment Outcome. Zinc Compounds / therapeutic use

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  • (PMID = 15046435.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chlorides; 0 / Zinc Compounds; 86Q357L16B / zinc chloride
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2. Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA: Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J; 2006;26:69-76
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  • [Title] Ethanol as a local adjuvant for giant cell tumor of bone.
  • Giant cell tumor is an aggressive benign neoplasm of bone.
  • A number of adjuvant agents have been used to supplement intralesional curettage to reduce the otherwise high local recurrence rate.
  • No report on its use in a group of patients with giant cell tumor is available.
  • Until such evidence becomes available, the use of adjuvant ethanol offers a compromise between higher toxicity adjuvants and no chemical adjuvant at all.
  • [MeSH-major] Bone Neoplasms / therapy. Ethanol / therapeutic use. Giant Cell Tumor of Bone / therapy

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  • (PMID = 16789453.001).
  • [ISSN] 1541-5457
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
  • [Other-IDs] NLM/ PMC1888590
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3. Mitra R: Osteitis Condensans Ilii. Rheumatol Int; 2010 Jan;30(3):293-6
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  • Osteitis Condensans Ilii (OCI) is a benign cause of axial low back pain.
  • The location of the sclerosis has been traditionally confined to the ilium and may give the false impression of sacro-iliac joint involvement.
  • Treatments for the condition are primarily conservative (therapies, non-steroidal anti-inflammatory medications, and steroid injections), with surgical resection being reserved for refractory cases.
  • [MeSH-major] Ilium / pathology. Ilium / physiopathology. Low Back Pain / etiology. Low Back Pain / physiopathology. Osteitis / diagnosis. Osteitis / physiopathology
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Diagnosis, Differential. Humans. Neoplasm Metastasis / diagnosis. Radiography. Radiology. Sacroiliac Joint / diagnostic imaging. Sacroiliac Joint / pathology. Sacroiliac Joint / physiopathology. Spondylitis, Ankylosing / diagnosis. Steroids / therapeutic use

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  • (PMID = 19711079.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Steroids
  • [Number-of-references] 24
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4. Takahashi S, Okada K, Nagasawa H, Shimada Y, Sakamoto H, Itoi E: Osteosarcoma occurring in osteogenesis imperfecta. Virchows Arch; 2004 May;444(5):454-8
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  • High-dose ifosfamide therapy caused marked tumor regression of multiple lung metastases.
  • Immunohistochemically, the tumor cells were diffusely positive for the p53 protein.
  • The radiographic characteristics, including irregularly distributed osteolytic lesions and cortical discontinuity, should not be confused with hyperplastic callus formation, a benign process.
  • A biopsy is critical to establish the differential diagnosis between osteosarcoma and common hyperplastic callus formation in OI; however, it must be applied with great care.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Combined Modality Therapy. DNA Mutational Analysis. DNA, Neoplasm / analysis. Doxorubicin / administration & dosage. Humans. Ifosfamide / therapeutic use. Immunohistochemistry. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Methotrexate / administration & dosage. Radiography, Thoracic. Thigh / pathology. Thigh / surgery. Tomography, X-Ray Computed. Treatment Outcome. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / genetics


5. Micheli A, Trapani S, Brizzi I, Campanacci D, Resti M, de Martino M: Myositis ossificans circumscripta: a paediatric case and review of the literature. Eur J Pediatr; 2009 May;168(5):523-9
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  • At onset, it is difficult to distinguish MOC from a musculoskeletal infection or neoplasm, particularly in absence of trauma, and a biopsy is frequently required.
  • Hypothesising a periarticular infection, a wide-spectrum antibiotic and an anti-inflammatory drug were given.
  • Three months after diagnosis, surgical excision was performed.
  • Our case study confirms the good prognosis of MOC and underlines how this benign condition should be considered in children presenting a tender and painful soft-tissue swelling.
  • [MeSH-major] Bone and Bones. Musculoskeletal Diseases. Myositis Ossificans / diagnosis. Myositis Ossificans / physiopathology
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents / therapeutic use. Biopsy. Child. Diagnosis, Differential. Humans. Lymphadenitis / diagnosis. Magnetic Resonance Imaging. Male. Muscle, Skeletal / metabolism. Muscle, Skeletal / pathology. Necrosis / pathology. Osteoblasts / metabolism. Sarcoma / pathology. Soft Tissue Injuries / diagnosis. Soft Tissue Injuries / metabolism. Soft Tissue Injuries / pathology

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  • (PMID = 19130083.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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  • [Number-of-references] 35
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6. de Prado Prieto L, García Olmos L, Rodríguez Salvanés F, Otero Puime A: [Evaluation of referrals in primary care]. Aten Primaria; 2005 Feb 28;35(3):146-51
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  • [Transliterated title] Evaluación de la demanda derivada en atención primaria.
  • The specialties that received more referrals are gynecologist, ophthalmology, dermatology, otorhinolaryngology, rehabilitation, orthopedic surgeon and general surgeon.
  • The most common conditions referred, 25.6% of all referrals, are gynecologist check, blindness, other illnesses of subcutaneous cellular tissue, arthrosis, joint pain, diabetes, benign neoplasm of skin, depression and hypoacusis.
  • Although people are more participative, have more information and the defensive medicine is increasing, the process of referral have not changed.

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  • (PMID = 15737271.001).
  • [ISSN] 0212-6567
  • [Journal-full-title] Atencion primaria
  • [ISO-abbreviation] Aten Primaria
  • [Language] SPA
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Spain
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7. Contreras A, Isasi C, Silveira J, Barbadillo C, Mulero J, Andreu JL: Intra-articular osteoid osteoma at the elbow: report of a case and review of the literature. J Clin Rheumatol; 2000 Aug;6(4):218-20
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  • Osteoid osteoma is a benign tumor that may occur in almost any part of any bone.
  • Diagnosis can be difficult, particularly when it is intra-articular.
  • In these cases, osteoid osteoma may present initially with symptoms suggestive of inflammatory arthritis, degenerative joint disease, neoplasm, or infection.
  • The patient did not have a typical pattern of pain, did not have the typical relief with anti-inflammatory agents, and misinterpretation of the radiographs led to a delay in the diagnosis and definitive treatment.
  • Surgical excision confirmed the diagnosis and resulted in resolution of the monoarthritis.
  • A definitive diagnosis depends on surgical excision and histologic confirmation.
  • Ahigh index of suspicion is necessary to make the diagnosis.

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  • (PMID = 19078475.001).
  • [ISSN] 1536-7355
  • [Journal-full-title] Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • [ISO-abbreviation] J Clin Rheumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Skubitz KM, Manivel JC: Giant cell tumor of the uterus: case report and response to chemotherapy. BMC Cancer; 2007;7:46
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  • [Title] Giant cell tumor of the uterus: case report and response to chemotherapy.
  • BACKGROUND: Giant cell tumor (GCT) is usually a benign but locally aggressive primary bone neoplasm in which monocytic macrophage/osteoclast precursor cells and multinucleated osteoclast-like giant cells infiltrate the tumor.
  • The etiology of GCT is unknown, however the tumor cells of GCT have been reported to produce chemoattractants that can attract osteoclasts and osteoclast precursors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Giant Cell Tumors / drug therapy. Uterine Neoplasms / drug therapy
  • [MeSH-minor] Angiogenesis Inhibitors / administration & dosage. Antibiotics, Antineoplastic / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Agents, Alkylating / administration & dosage. Bevacizumab. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Hysterectomy. Ifosfamide / administration & dosage. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Middle Aged. Treatment Outcome

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  • (PMID = 17359524.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibiotics, Antineoplastic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents, Alkylating; 2S9ZZM9Q9V / Bevacizumab; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 57
  • [Other-IDs] NLM/ PMC1832205
  •  go-up   go-down






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