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[Title] Renal neoplasms in younger adults: analysis of 112 tumors from a single institution according to the new 2004 World Health Organization classification and 2002 American Joint Committee on Cancer Staging System.

Recent modification of the World Health Organization histologic classification and the American Joint Committee on Cancer staging system of adult renal tumors further highlighted the need for case analysis in this age group.

The tumors were reevaluated according to the 2004 World Health Organization classification and the 2002 American Joint Committee on Cancer staging system.

Seventeen percent of these tumors had multilocular cystic features involving more than 50% of the tumor volume (55%-85%).

The number of oncocytomas was also significantly lower in younger adults than in older adults (2% vs 11%, P < .001), and this presumably age-related benign neoplasm was not identified in patients younger than 40 years in this study.

In contrast, the miscellaneous tumor category showed a remarkable increase, from 4% in older adults to 26% in younger adults (P < .001).

Younger female adults tended to have more benign miscellaneous neoplasms than did their male counterparts (64% vs 36%, P < .001).

Malignant and benign renal neoplasms tend to have a contrasting sex distribution in younger adults.

[MeSH-minor] Adult. Age Distribution. Female. Humans. Male. Neoplasm Staging. Sex Distribution

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(PMID = 15794671.001).

[ISSN] 1543-2165

[Journal-full-title] Archives of pathology & laboratory medicine

[ISO-abbreviation] Arch. Pathol. Lab. Med.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Malignant Natural-Killer cell neoplasm presenting as a mucous cyst on the distal interphalangeal joint of the finger.

The analysis revealed the presence of a Natural-Killer cell neoplasm.

This case illustrates and stresses the importance of a pathohistological examination when doubts arise about the initial diagnosis of a benign tumorous lesion.

[MeSH-minor] Aged. Cysts / diagnosis. Fingers. Humans. Male

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(PMID = 19084980.001).

[ISSN] 1434-3916

[Journal-full-title] Archives of orthopaedic and trauma surgery

[ISO-abbreviation] Arch Orthop Trauma Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Germany

   

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Although most primary bone tumors and soft tissue tumors arise around the knee joint, many patients with tumoral conditions attribute their symptoms to traumatic events.

Arthroscopy is the preferred method for diagnosis and treatment of knee joint disease, but even a minimally invasive procedure may have adverse consequences in the presence of an unsuspected neoplasm.

In addition, arthroscopy is a useful adjunct during surgical treatment of patients with certain juxta-articular benign bone tumors.

In this Current Concepts review, we consider the risks and benefits of arthroscopy in the presence of tumors about the knee joint.

[MeSH-major] Arthroscopy. Bone Neoplasms / surgery. Knee Joint

[MeSH-minor] Biopsy. Humans. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery

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(PMID = 16651168.001).

[ISSN] 1526-3231

[Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

[ISO-abbreviation] Arthroscopy

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 29

   

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The study was set up to correlate diagnosis, staging and treatment with the outcome.

Oncological and functional results were recorded for all patients at periodic, diagnosis-related controls, until death or the latest follow-up examination (from 0 to 211 months, median 47 months, 25th-75th percentile 22-85 months).

Of the 35 patients with a recurrent or contaminated tumor, 16 (45.7%) suffered at least one complication; by contrast, complications arose in 31 (31.3%) of the 99 patients who had had no previous treatment and who underwent the whole of their treatment in the same center (P = 0.125).

Re-operations were mostly due to tumor recurrences, but also to hardware failures, wound dehiscence, hematomas and aortic dissection.

En bloc resection is able to improve the prognosis of aggressive benign and low-grade malignant tumors in the spine; however, complications are not rare and possibly fatal.

[MeSH-minor] Adult. Aged. Aortic Rupture / mortality. Equipment Failure. Female. Humans. Male. Middle Aged. Mortality. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Radiotherapy / adverse effects. Reoperation / mortality. Retrospective Studies. Surgical Wound Dehiscence / mortality. Surgical Wound Infection / mortality. Treatment Outcome

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(PMID = 19690899.001).

[ISSN] 1432-0932

[Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

[ISO-abbreviation] Eur Spine J

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Other-IDs] NLM/ PMC2899819

   

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While prostate tumor tissues with Gleason scores >or= 7, displayed predominantly nuclear CXCR5 expression patterns, PCa specimens with Gleason scores <or= 6 showed predominantly membrane and cytoplasmic expression patterns that were comparable to benign prostatic hyperplasia (BPH).

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(PMID = 19610059.001).

[ISSN] 1097-0215

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / U54 CA118638; United States / NCRR NIH HHS / RR / G12 RR003034; United States / NCI NIH HHS / CA / U54 CA118623; United States / NCI NIH HHS / CA / U54 CA118948; United States / NIMHD NIH HHS / MD / P60 MD000525-03; United States / NIMHD NIH HHS / MD / MD00525; United States / NIMHD NIH HHS / MD / P60 MD000525; United States / NIAID NIH HHS / AI / AI057808; United States / NCI NIH HHS / CA / U54 CA118638-06; United States / NIGMS NIH HHS / GM / S06 GM008248; United States / NIGMS NIH HHS / GM / GM09248; United States / NIAID NIH HHS / AI / R01 AI057808; United States / NIDDK NIH HHS / DK / DK58967; United States / NIAID NIH HHS / AI / AI057808-05; United States / NCI NIH HHS / CA / U54 CA118638-07; United States / NCI NIH HHS / CA / U24 CA086359; United States / NIGMS NIH HHS / GM / GM08248; United States / NCI NIH HHS / CA / U56 CA092078; United States / NIAID NIH HHS / AI / R01 AI057808-05; United States / NCI NIH HHS / CA / CA086359; United States / NCI NIH HHS / CA / CA092078

[Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / CXCL13 protein, human; 0 / CXCR5 protein, human; 0 / Chemokine CXCL13; 0 / RNA, Messenger; 0 / Receptors, CXCR5; EC 3.4.24.- / Matrix Metalloproteinases

[Other-IDs] NLM/ NIHMS137666; NLM/ PMC3600527

   

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In this study, we present the first evidence that CXCL13, the only ligand for CXCR5, and IL-6 were significantly elevated in PCa patient serum compared to serum from subjects with benign prostatic hyperplasia (BPH), or high-grade prostatic intraepithelial neoplasia (HGPIN) as well as normal healthy donors (NHD).

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(PMID = 19375853.001).

[ISSN] 1872-7980

[Journal-full-title] Cancer letters

[ISO-abbreviation] Cancer Lett.

[Language] ENG

[Grant] United States / NCRR NIH HHS / RR / G12 RR003034-27; United States / NCRR NIH HHS / RR / G12 RR003034-23; United States / NCRR NIH HHS / RR / G12 RR003034; United States / NCI NIH HHS / CA / U24 CA086359-10; United States / NIMHD NIH HHS / MD / P60 MD000525-03; United States / NIMHD NIH HHS / MD / MD00525; United States / NIMHD NIH HHS / MD / P60 MD000525; United States / NIAID NIH HHS / AI / AI057808; United States / NCRR NIH HHS / RR / RR003034-23; United States / NIGMS NIH HHS / GM / S06 GM008248; United States / NIGMS NIH HHS / GM / GM09248; United States / NCRR NIH HHS / RR / RR03034; United States / NIGMS NIH HHS / GM / GM008248-22; United States / NIAID NIH HHS / AI / R01 AI057808; United States / NIDDK NIH HHS / DK / DK58967; United States / NCI NIH HHS / CA / U24CA86359.; United States / NCI NIH HHS / CA / U24 CA086359; United States / NIGMS NIH HHS / GM / GM08248; United States / NIGMS NIH HHS / GM / S06 GM008248-22; United States / NCI NIH HHS / CA / U56 CA092078; United States / NCI NIH HHS / CA / CA086359-10; United States / NCI NIH HHS / CA / CA092078

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] Ireland

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CXCL13 protein, human; 0 / CXCR5 protein, human; 0 / Chemokine CXCL13; 0 / Integrins; 0 / Interleukin-6; 0 / Receptors, CXCR5; EC 3.4.21.77 / Prostate-Specific Antigen

[Other-IDs] NLM/ NIHMS140687; NLM/ PMC3600557

   

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[Title] Benign fibro-osseous lesions of the craniofacial complex. A review.

Benign fibro-osseous lesions of the craniofacial complex are represented by a variety of disease processes that are characterized by pathologic ossifications and calcifications in association with a hypercellular fibroblastic marrow element.

The definitive diagnosis can rarely be rendered on the basis of histopathologic features alone; rather, procurement of a final diagnosis is usually dependent upon assessment of microscopic, clinical and imaging features together.

[MeSH-major] Cementoma / diagnosis. Fibroma, Ossifying / diagnosis. Fibrous Dysplasia of Bone / diagnosis. Osteitis Deformans / diagnosis. Skull Neoplasms / diagnosis

[MeSH-minor] DNA, Neoplasm / analysis. Humans. Mutation

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(PMID = 20614314.001).

[ISSN] 1936-0568

[Journal-full-title] Head and neck pathology

[ISO-abbreviation] Head Neck Pathol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Neoplasm

[Other-IDs] NLM/ PMC2807558

[Keywords] NOTNLM ; Benign fibroosseous lesions / Cementoma / Cementoosseous dysplasia / Fibrous dysplasia / Ossifying fibroma / Osteitis deformans

   

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[Title] Pseudogout mimicking an infratemporal fossa tumor.

METHODS AND RESULTS: We present a case of a 71-year-old woman who presented with worsening facial pain, trismus, and a large mass in her infratemporal fossa with minimal associated temporomandibular joint destruction.

CONCLUSION: The clinical and radiological features of patients with tophaceous pseudogout frequently mimic those of a benign or malignant neoplasm of the infratemporal fossa, often resulting in more radical surgery.

[MeSH-major] Chondrocalcinosis / diagnosis. Chondrocalcinosis / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / surgery. Temporal Bone / surgery

[MeSH-minor] Aged. Diagnosis, Differential. Facial Pain / etiology. Female. Humans. Otorhinolaryngologic Surgical Procedures / methods. Temporomandibular Joint / pathology. Treatment Outcome. Trismus / etiology

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(PMID = 19283846.001).

[ISSN] 1097-0347

[Journal-full-title] Head & neck

[ISO-abbreviation] Head Neck

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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Routine light microscopy supplemented with immunohistochemistry in cases of metastatic or spindle cell melanoma are standards of care for the diagnosis and staging of melanoma.

Not all melanocytic tumors can be confidently classified as melanoma or benign nevus by histology, however.

In addition, tumor thickness and ulceration, the current American Joint Classification on Cancer prognosticators for primary cutaneous (stages I and II) melanoma used in clinical practice, do not perfectly predict an individual's clinical course.

Recent advances in molecular techniques and bioinformatics mandate testing and use of novel methods for the detection, diagnosis, and classification of melanocytic tumors that can accurately predict tumor behavior and help in selecting the most optimal and individualized therapy.

[MeSH-minor] Cytogenetic Analysis. Dermatology / methods. Humans. Immunohistochemistry. Molecular Diagnostic Techniques. Neoplasm Staging. Prognosis

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(PMID = 19095155.001).

[ISSN] 1879-1131

[Journal-full-title] Clinics in dermatology

[ISO-abbreviation] Clin. Dermatol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 288

   

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There is no study discussing the differential diagnosis of clavicular lesions based on the site of occurrence or age at presentation.

This study aims to determine whether the distribution of lesions affecting the clavicle and age at presentation aid in the differential diagnosis of focal clavicular lesions.

Virtually, all patients had been referred as suspected neoplasm.

Patients <20 years (n = 27) had non-neoplastic or benign lesions.

The lesions most commonly affected the medial third (n = 35) and were predominantly non-neoplastic or benign.

The middle third was affected in 15 patients and showed both benign and malignant lesions.

CONCLUSIONS: The clavicle is not a primary common site for any particular tumour; hence, diagnosis of the lesions can be challenging.

Our study has suggested that few factors like age and site of the lesions may be helpful in diagnosis.

[MeSH-major] Bone Diseases / diagnosis. Clavicle / pathology

[MeSH-minor] Adult. Biopsy. Bone Neoplasms / diagnosis. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Osteomyelitis / diagnosis. Tomography, X-Ray Computed / methods

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(PMID = 18483738.001).

[ISSN] 0364-2348

[Journal-full-title] Skeletal radiology

[ISO-abbreviation] Skeletal Radiol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

   

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Mediastinal node staging was determined using the American Joint Committee on Cancer (AJCC) staging system.

After lymph nodes with calcification and bilateral hilar distribution were considered benign, sensitivity and specificity of PET/CT were 75% and 89% on a per-patient basis and 66% and 96% on a per-node station basis.

[MeSH-minor] Contrast Media. Endemic Diseases. False Positive Reactions. Female. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Radiography, Thoracic. Sensitivity and Specificity. Tomography, X-Ray Computed

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(PMID = 19430783.001).

[ISSN] 1619-7089

[Journal-full-title] European journal of nuclear medicine and molecular imaging

[ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging

[Language] eng

[Publication-type] Clinical Trial; Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Contrast Media; 0Z5B2CJX4D / Fluorodeoxyglucose F18

   

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INTRODUCTION: A synovial chondromatosis is a rare benign neoplasm on the synovium.

Although described as a benign disease, it can be very destructive and can cause severe osteoarthritis and pain.

To the best of our knowledge, we report the first known case of an extensive presentation of this intra-articular and extra-articular disease of the knee joint.

CONCLUSIONS: Although synovial chondromatosis is described as a benign disease, it can be very destructive and debilitating.

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[Cites] J Bone Joint Surg Am. 2007 Jun;89(6):1321-8 [17545437.001]

(PMID = 20416049.001).

[ISSN] 1752-1947

[Journal-full-title] Journal of medical case reports

[ISO-abbreviation] J Med Case Rep

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2873448

   

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[Title] Isolated cardiac metastasis from a histologically "benign" giant-cell tumor of the distal end of the femur: a case report.

[MeSH-major] Bone Neoplasms / pathology. Femur / pathology. Giant Cell Tumor of Bone / secondary. Heart Neoplasms / secondary

[MeSH-minor] Adult. Biopsy, Needle. Disease Progression. Fatal Outcome. Heart Failure / diagnosis. Humans. Immunohistochemistry. Male. Neoplasm Staging. Orthopedic Procedures / methods. Tomography, X-Ray Computed / methods

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(PMID = 21084583.001).

[ISSN] 1535-1386

[Journal-full-title] The Journal of bone and joint surgery. American volume

[ISO-abbreviation] J Bone Joint Surg Am

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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METHODS: CRC cell lines (n = 6) and tumor specimens (n = 139) from patients with different American Joint Committee on Cancer (AJCC) stages of CRC were assessed.

CXCR4 expression in tumor and benign specimens was assessed by quantitative real-time reverse transcription polymerase chain reaction and correlated with disease recurrence and overall survival.

RESULTS: High CXCR4 expression in tumor specimens (n = 57) from AJCC stage I/II patients was associated with increased risk for local recurrence and/or distant metastasis (risk ratio, 1.35; 95% CI, 1.09 to 1.68; P = .0065).

High CXCR4 expression in primary tumor specimens (n = 35) from AJCC stage IV patients correlated with worse overall median survival (9 months v 23 months; RR, 2.53; 95% CI, 1.19 to 5.40; P = .016).

[MeSH-major] Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Gene Expression Profiling. Liver Neoplasms / genetics. Liver Neoplasms / secondary. Neoplasm Recurrence, Local / genetics. Receptors, CXCR4 / biosynthesis

[MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / physiopathology. Prognosis. Risk Factors. Signal Transduction. Survival Analysis. Tumor Cells, Cultured

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(PMID = 15837989.001).

[ISSN] 0732-183X

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / R01-CA90848-02

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Receptors, CXCR4

   

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Myositis ossificans circumscripta is a form of heterotopic ossification that is benign in nature associated to a trauma, but may appear clinically and radiologically as a malignant neoplasm.

We discuss some of the difficulties of diagnosis and histological evolution of the lesion.

KEYWORDS: Myositis ossificans; Thigh; Differential diagnosis; Nontraumatic.

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[Cites] Clin Radiol. 2002 Dec;57(12):1058-66 [12475528.001]

[Cites] Orthop Rev. 1992 Nov;21(11):1319-26 [1461667.001]

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(PMID = 21629528.001).

[ISSN] 1918-3011

[Journal-full-title] Journal of clinical medicine research

[ISO-abbreviation] J Clin Med Res

[Language] eng

[Publication-type] Journal Article

[Publication-country] Canada

[Other-IDs] NLM/ PMC3104644

   

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[Title] Surgical management of 121 benign proximal fibula tumors.

Patients with aggressive benign tumors in the proximal fibula may require en bloc resection.

QUESTIONS/PURPOSES: We therefore analyzed the incidence of peroneal nerve palsy, knee stability, and local recurrence following surgical treatment of benign proximal fibula tumors.

METHODS: We retrospectively reviewed the charts of 120 patients (121 tumors) with histologically confirmed aggressive benign tumors of the proximal fibula.

The most common diagnosis was osteochondroma (38%) followed by giant cell tumor (19%).

[MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Curettage / adverse effects. Female. Humans. Joint Instability / etiology. Joint Instability / physiopathology. Knee Joint / physiopathology. Male. Middle Aged. Neoplasm Recurrence, Local. Osteotomy / adverse effects. Peroneal Neuropathies / etiology. Range of Motion, Articular. Retrospective Studies. Surgical Wound Dehiscence / etiology. Time Factors. Treatment Outcome. Venous Thrombosis / etiology. Young Adult

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[Cites] Clin Orthop Relat Res. 2002 Sep;(402):110-21 [12218476.001]

[Cites] Clin Orthop Relat Res. 2007 Jan;454:198-201 [16936590.001]

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(PMID = 20625947.001).

[ISSN] 1528-1132

[Journal-full-title] Clinical orthopaedics and related research

[ISO-abbreviation] Clin. Orthop. Relat. Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2947668

   

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This SI pattern is unusual for common benign liver lesions and may be helpful in the MR imaging diagnosis of colorectal liver metastases. (c) RSNA, 2010.

[MeSH-major] Colorectal Neoplasms / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Magnetic Resonance Imaging / methods

[MeSH-minor] Adult. Aged. Female. Humans. In Vitro Techniques. Linear Models. Male. Middle Aged. Neoplasm Staging. Prospective Studies

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(PMID = 20123902.001).

[ISSN] 1527-1315

[Journal-full-title] Radiology

[ISO-abbreviation] Radiology

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland.

METHODS: The concentrations of salivary CEA and CA-50 were assayed in 80 patients of oral and salivary malignant tumors, 40 patients of benign tumors and 80 health controls.

RESULTS: Salivary CEA and CA-50 levels were significantly higher in malignant tumors than in benign tumors and in health controls, respectively (P < 0.001).

This may be more useful as prognostic indicators in early diagnosis of oral and salivary malignant tumors.

[MeSH-major] Adenoma / blood. Antigens, Tumor-Associated, Carbohydrate / analysis. Carcinoembryonic Antigen / analysis. Mouth Neoplasms / blood. Saliva / chemistry. Salivary Gland Neoplasms / blood

[MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunoradiometric Assay. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Young Adult

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(PMID = 19322585.001).

[ISSN] 1432-1335

[Journal-full-title] Journal of cancer research and clinical oncology

[ISO-abbreviation] J. Cancer Res. Clin. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / CA-50 antigen; 0 / Carcinoembryonic Antigen

   

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[Title] MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm.

Dynamic enhancement pattern corresponded to the type usually seen in benign soft tissue lesions.

CONCLUSION: Focal myositis is an uncommon pseudotumour which should be considered in the differential diagnosis of muscular masses and myopathies.

[MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Young Adult

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(PMID = 19255757.001).

[ISSN] 1432-2161

[Journal-full-title] Skeletal radiology

[ISO-abbreviation] Skeletal Radiol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

   

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[Title] Rare benign tumors of the mandibular condyle: report of 2 cases and literature review.

[MeSH-minor] Adult. Diagnosis, Differential. Dislocations / etiology. Dislocations / surgery. Facial Asymmetry / etiology. Facial Asymmetry / surgery. Female. Humans. Neoplasm Invasiveness. Rare Diseases. Temporomandibular Joint Disc / surgery. Temporomandibular Joint Disorders / etiology. Temporomandibular Joint Disorders / surgery

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(PMID = 17719407.001).

[ISSN] 0278-2391

[Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

[ISO-abbreviation] J. Oral Maxillofac. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] United States

[Number-of-references] 25

   

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[Title] A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases.

Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis.

Vascular invasion outside the boundary of the tumor can be seen.

Metastasis, with identical morphology to the primary tumor, occurs in a few percent of cases, usually to the lung.

[MeSH-major] Bone Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local. Tibia / pathology

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(PMID = 20860830.001).

[ISSN] 1746-1596

[Journal-full-title] Diagnostic pathology

[ISO-abbreviation] Diagn Pathol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Bone Cements

[Other-IDs] NLM/ PMC2954972

   

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Osteoid osteoma is a benign skeletal neoplasm of unknown etiology that is composed of osteoid and woven bone.

Its incidence is 11% of benign tumors and 3% of all primary bone tumors, with 6% to 13% of all cases occurring in the hand.

Osteoid osteoma of the hamate can produce ulnar-sided wrist pain in the dorsal or volar aspect of the wrist, depending on the location of the tumor in the bone.

A tumor located in the hook will produce volar pain.

[MeSH-major] Arthralgia / diagnosis. Bone Neoplasms / pathology. Hamate Bone / pathology. Osteoma, Osteoid / pathology. Ulna / pathology

[MeSH-minor] Humans. Male. Treatment Outcome. Wrist Joint / pathology. Wrist Joint / physiopathology. Wrist Joint / surgery. Young Adult

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[Copyright] Copyright 2010, SLACK Incorporated.

(PMID = 20608627.001).

[ISSN] 1938-2367

[Journal-full-title] Orthopedics

[ISO-abbreviation] Orthopedics

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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Grade 1 chondrosarcomas have little or no metastatic potential and are often difficult to distinguish from painful benign enchondromas.

Patients were followed a minimum of 18 months (average, 47.2. months; range, 18-134 months) for evidence of recurrence and for assessment of Musculoskeletal Tumor Society (MSTS) functional score.

RESULTS: Two of the 46 patients had recurrences in the original tumor site (4.3% recurrence rate), which subsequently were removed by wide excision, and both patients were confirmed to be disease-free 36 and 30 months, respectively, after the second surgery.

[MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Recovery of Function. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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(PMID = 20574801.001).

[ISSN] 1528-1132

[Journal-full-title] Clinical orthopaedics and related research

[ISO-abbreviation] Clin. Orthop. Relat. Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC3049634

   

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At onset, it is difficult to distinguish MOC from a musculoskeletal infection or neoplasm, particularly in absence of trauma, and a biopsy is frequently required.

Three months after diagnosis, surgical excision was performed.

Our case study confirms the good prognosis of MOC and underlines how this benign condition should be considered in children presenting a tender and painful soft-tissue swelling.

[MeSH-major] Bone and Bones. Musculoskeletal Diseases. Myositis Ossificans / diagnosis. Myositis Ossificans / physiopathology

[MeSH-minor] Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents / therapeutic use. Biopsy. Child. Diagnosis, Differential. Humans. Lymphadenitis / diagnosis. Magnetic Resonance Imaging. Male. Muscle, Skeletal / metabolism. Muscle, Skeletal / pathology. Necrosis / pathology. Osteoblasts / metabolism. Sarcoma / pathology. Soft Tissue Injuries / diagnosis. Soft Tissue Injuries / metabolism. Soft Tissue Injuries / pathology

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(PMID = 19130083.001).

[ISSN] 1432-1076

[Journal-full-title] European journal of pediatrics

[ISO-abbreviation] Eur. J. Pediatr.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Germany

[Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents

[Number-of-references] 35

   

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BACKGROUND: Chondroblastoma is a rare benign bone lesion that occurs in young patients and has a high rate of recurrence.

METHODS: We retrospectively reviewed eighty-seven cases of chondroblastoma in patients with open physes at the time of diagnosis and treatment.

[MeSH-major] Bone Neoplasms / epidemiology. Chondroblastoma / epidemiology. Femur. Neoplasm Recurrence, Local / epidemiology. Tibia

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(PMID = 19723993.001).

[ISSN] 1535-1386

[Journal-full-title] The Journal of bone and joint surgery. American volume

[ISO-abbreviation] J Bone Joint Surg Am

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] United States

   

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[Title] Ethanol as a local adjuvant for giant cell tumor of bone.

Giant cell tumor is an aggressive benign neoplasm of bone.

No report on its use in a group of patients with giant cell tumor is available.

[MeSH-major] Bone Neoplasms / therapy. Ethanol / therapeutic use. Giant Cell Tumor of Bone / therapy

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COS Scholar Universe. author profiles.

Hazardous Substances Data Bank. ETHANOL .

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(PMID = 16789453.001).

[ISSN] 1541-5457

[Journal-full-title] The Iowa orthopaedic journal

[ISO-abbreviation] Iowa Orthop J

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 3K9958V90M / Ethanol

[Other-IDs] NLM/ PMC1888590

   

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[Title] Nodular fasciitis of the hand over the metacarpophalangeal joint: a case report.

OBJECTIVE: This study describes a case of nodular fasciitis involving the hand and reviews the neoplasm's pertinent clinical, histologic, and pathologic features.

CONCLUSIONS: Nodular fasciitis is a self-limited, benign soft tissue tumor composed of fibroblasts and myofibroblasts that typically afflicts younger patients and rarely presents in the hand.

Because of its presentation, it can be easily mistaken for a malignant neoplasm.

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(PMID = 18725954.001).

[ISSN] 1937-5719

[Journal-full-title] Eplasty

[ISO-abbreviation] Eplasty

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2491338

   

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[Title] Knee reconstruction with preservation of the meniscus in tibial giant cell tumor.

Giant cell tumor of bone sometimes is an aggressive benign skeletal tumor.

Thus, maintaining joint function and achieving adequately wide resection introduces contradictory surgical goals.

We reconstructed 13 knees preserving the meniscus and reconstructing the tibial plateau with an iliac plate autograft after resection of a giant cell tumor involving one tibial plateau.

While resecting the tumor, the normal anatomic structures of the knee can be preserved or restored in many patients.

[MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Orthopedic Procedures / methods. Reconstructive Surgical Procedures / methods

[MeSH-minor] Adult. Bone Transplantation. Female. Humans. Ilium / transplantation. Male. Menisci, Tibial. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Tibia. Transplantation, Autologous. Young Adult

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[Cites] Clin Orthop Relat Res. 2002 Apr;(397):248-58 [11953616.001]

[Cites] Clin Orthop Relat Res. 2005 Jun;(435):211-8 [15930941.001]

[Cites] J Bone Joint Surg Br. 2004 Mar;86(2):212-6 [15046435.001]

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[Cites] J Bone Joint Surg Am. 1999 Jun;81(6):811-20 [10391546.001]

[Cites] Clin Orthop Relat Res. 2002 Apr;(397):259-70 [11953617.001]

(PMID = 18830792.001).

[ISSN] 1528-1132

[Journal-full-title] Clinical orthopaedics and related research

[ISO-abbreviation] Clin. Orthop. Relat. Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2628220

   

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OBJECTIVE: To investigate the expressions of VEGF in prostate cancer (PCa) and benign prostatic hyperplasia (BPH), their clinical significance and their relationship with that of ET-1.

VEGF and ET-1 may play a joint role in its development and progression.

[MeSH-minor] Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Prostatic Hyperplasia / metabolism. Prostatic Hyperplasia / pathology

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(PMID = 19102498.001).

[ISSN] 1009-3591

[Journal-full-title] Zhonghua nan ke xue = National journal of andrology

[ISO-abbreviation] Zhonghua Nan Ke Xue

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Endothelin-1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1

   

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Tumour types included 38 primary musculoskeletal malignancies, 8 metastatic tumours, 2 bony lymphomas and 2 benign lesions.

[MeSH-major] Arthroplasty, Replacement, Knee. Joint Diseases / surgery. Knee Joint / surgery. Limb Salvage. Neoplasms / surgery

[MeSH-minor] Adolescent. Adult. Aged. Amputation. Bone Neoplasms / surgery. Female. Follow-Up Studies. Humans. Intraoperative Complications. Joint Prosthesis. Male. Middle Aged. Muscle Neoplasms / surgery. Neoplasm Metastasis. Popliteal Artery / injuries. Postoperative Complications. Prosthesis Failure. Reoperation. Retrospective Studies. Surgical Wound Infection / etiology. Survival Rate. Treatment Outcome

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(PMID = 17291709.001).

[ISSN] 0748-7983

[Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

[ISO-abbreviation] Eur J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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METHODS: 20 patients with histologically benign GCT of the pelvis were included in this study.

RESULTS: 1 patient with a pubic tumor developed a local recurrence 1 year after intralesional resection and additional curettage of the margins.

[MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Pelvic Bones

[MeSH-minor] Adult. Aged. Bone Cements. Bone Transplantation. Curettage. Embolization, Therapeutic / methods. Female. Follow-Up Studies. Humans. Ilium / pathology. Ilium / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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(PMID = 19916695.001).

[ISSN] 1745-3682

[Journal-full-title] Acta orthopaedica

[ISO-abbreviation] Acta Orthop

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Bone Cements

[Other-IDs] NLM/ PMC2823344

   

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[Title] Cemented distal femoral endoprostheses for musculoskeletal tumor: improved survival of modular versus custom implants.

We excluded two patients with cementless implants, 27 with expandable prostheses, and 39 who had a nontumor diagnosis.

The tumor was classified as Stage IIA/IIB in 122 patients, Stage IA/IB or benign in 43, and Stage III or metastatic in 21.

[MeSH-major] Bone Neoplasms / surgery. Femur / surgery. Joint Prosthesis. Prosthesis Failure. Reconstructive Surgical Procedures / instrumentation

[MeSH-minor] Adolescent. Adult. Aged. Cementation. Child. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prosthesis Design. Reoperation. Retrospective Studies. Young Adult

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(PMID = 20033359.001).

[ISSN] 1528-1132

[Journal-full-title] Clinical orthopaedics and related research

[ISO-abbreviation] Clin. Orthop. Relat. Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2895832

   

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There was no difference in baseline tumor characteristics between the two groups.

Given that higher radiation doses placed patients at greater risk for late complications such as fracture, fibrosis, edema, and joint stiffness, judicious avoidance of the postoperative boost while maintaining an equivalent rate of local control can reduce the risk of these difficult-to-treat morbidities.

[MeSH-minor] Adult. Aged. Aged, 80 and over. Amputation. Female. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / prevention & control. Histiocytoma, Benign Fibrous / radiotherapy. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / prevention & control. Leiomyosarcoma / radiotherapy. Leiomyosarcoma / surgery. Limb Salvage. Liposarcoma / pathology. Liposarcoma / prevention & control. Liposarcoma / radiotherapy. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm, Residual. Postoperative Care. Radiotherapy Dosage. Retreatment. Young Adult

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[Copyright] Copyright 2010 Elsevier Inc. All rights reserved.

[CommentIn] Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):959; author reply 959-60 [21621120.001]

(PMID = 20056340.001).

[ISSN] 1879-355X

[Journal-full-title] International journal of radiation oncology, biology, physics

[ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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The role of this procedure in the management of aggressive benign or malignant hand tumors has been described only in case reports and small case series.

The other was treated with radiotherapy alone, as local tumor control would have required a hand amputation.

Functional assessment based on the Musculoskeletal Tumor Society staging system showed an average of 27.5 (range, 21-30).

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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(PMID = 19655212.001).

[ISSN] 1528-1132

[Journal-full-title] Clinical orthopaedics and related research

[ISO-abbreviation] Clin. Orthop. Relat. Res.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2853661

   

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Giant cell tumours are rare bone tumours that are characteristically benign but locally aggressive, most frequently occurring in the distal femur with pathological fractures being common.

[MeSH-major] Femoral Fractures / epidemiology. Femoral Fractures / physiopathology. Femoral Neoplasms / physiopathology. Giant Cell Tumor of Bone / physiopathology

[MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local. Prospective Studies. Risk Factors

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(PMID = 16474936.001).

[ISSN] 0341-2695

[Journal-full-title] International orthopaedics

[ISO-abbreviation] Int Orthop

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Other-IDs] NLM/ PMC2532068

   

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[Title] Curettage of benign bone tumors without grafts gives sufficient bone strength.

BACKGROUND AND PURPOSE: The defect that results after curettage of a bone tumor is usually filled in the same way.

We report the outcome in patients with benign bone tumors that were treated with curettage but no filling.

PATIENTS AND METHODS: We retrospectively studied 78 patients (mean age at the time of operation was 27 (6-73) years, 44 men) who had had a benign bone tumor curetted with no filling of the defect.

The commonest tumor types were giant cell tumor of bone (27), fibrous dysplasia (13), enchondroma (9), and simple bone cyst (7).

Local recurrence occurred in 9 patients; 7 of them had a giant cell tumor.

[MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Remodeling / physiology. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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(PMID = 19234882.001).

[ISSN] 1745-3682

[Journal-full-title] Acta orthopaedica

[ISO-abbreviation] Acta Orthop

[Language] eng

[Publication-type] Journal Article

[Publication-country] Sweden

[Other-IDs] NLM/ PMC2823236