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1. Niederle MB, Hackl M, Kaserer K, Niederle B: Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocr Relat Cancer; 2010 Dec;17(4):909-18
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  • [Title] Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters.
  • Using the current WHO classification, the tumor, nodes, metastases (TNM) staging and Ki67 grading and the standard diagnostic procedure proposed by the European Neuroendocrine Tumor Society (ENETS), GEP-NETs from 285 patients (male: 148; female: 137) were recorded.
  • The stomach (23%) was the main site, followed by appendix (21%), small intestine (15%) and rectum (14%).
  • About 46.0% were classified as benign, 15.4% as uncertain, 31.9% as well differentiated malignant and 6.7% as poorly differentiated malignant.
  • Patients with benign or uncertain tumours were significantly younger than patients with malignant tumours.
  • Among the malignant tumours of the digestive tract, 1.49% arose from neuroendocrine cells.
  • NETs of the digestive tract are more common than previously reported; the majority show benign behaviour, are located in the stomach and are well differentiated.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Neuroendocrine Tumors / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Age Factors. Austria / epidemiology. Female. Histocytochemistry. Humans. Incidence. Male. Middle Aged. Neoplasm Staging / methods. Prospective Studies

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  • (PMID = 20702725.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Fingleton B, Powell WC, Crawford HC, Couchman JR, Matrisian LM: A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. Hybridoma (Larchmt); 2007 Feb;26(1):22-7
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  • Immunostaining of MMP-7 in normal tissues or benign tumors of intestinal, breast, and prostatic origin indicates that this protein is normally localized luminally in glandular epithelium.
  • The localization pattern would suggest that in normal or early stage tumors, MMP-7 is most likely not directly involved in extracellular matrix degradation.
  • In contrast, advanced colon tumors show MMP-7 in invading cells at the advancing edge of the tumor.

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  • (PMID = 17316082.001).
  • [ISSN] 1554-0014
  • [Journal-full-title] Hybridoma (2005)
  • [ISO-abbreviation] Hybridoma (Larchmt)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA60867; United States / NCI NIH HHS / CA / R01 CA84360; United States / NIAMS NIH HHS / AR / AR36457; United States / NCI NIH HHS / CA / R01 CA084360; United States / NIAMS NIH HHS / AR / P30 AR48311; United States / NIAMS NIH HHS / AR / P30 AR048311; United States / NCI NIH HHS / CA / R01 CA100126; United States / NCI NIH HHS / CA / R01 CA060867
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Enzyme Precursors; EC 3.4.24.23 / Matrix Metalloproteinase 7
  • [Other-IDs] NLM/ NIHMS403810; NLM/ PMC3838102
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3. Engelman RW, Jackson RJ, Coppola D, Wharton W, Cantor AB, Pledger WJ: Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice. Exp Mol Pathol; 2007 Jun;82(3):234-44
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  • Although gamma-irradiated p21(+/-) mice develop a broad spectrum of tumors, gamma-irradiated p21(-/-) mice develop significantly more metastatic cancers.
  • To evaluate the expression of p21 in tissues prone or resistant to tumorigenesis as a function of gamma-irradiation, and to determine whether phenotypic loss of p21 heterozygosity occurs during tumor progression in p21(+/-) mice, tissues and tumors from gamma-irradiated mice were evaluated immunohistochemically.
  • The percentage of tumors in p21(+/-) mice that were nuclear p21-positive declined with progression to metastasis (p<0.0001).
  • Benign tumors were more often p21-positive and comprised of larger subsets of nuclear p21-positive cells than were malignant tumors of the same histopathological type, while metastatic cancers were nuclear p21-negative (p=0.0003).
  • Mesenchymal tumors, though rare, were more likely metastatic than were epithelial tumors (p=0.0004), and these were invariably nuclear p21-negative.
  • Prepubescent epithelial tissues from which most tumors later originated in mice with reduced p21 gene dosage (i.e., harderian gland, ovary, small intestine, and lung) were p21 expressive within 4 h of gamma-irradiation (p=0.0625), so that p21/Ki67 ratios increased post-gamma-irradiation (p=0.03).
  • Cellular subclones of malignant tumors, especially those of mesenchymal cell origin, which lack nuclear p21 may more readily acquire the genetic alterations of the metastatic phenotype.

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  • (PMID = 17207793.001).
  • [ISSN] 0014-4800
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA67360; United States / NCI NIH HHS / CA / P01 CA078038-040004; United States / NCI NIH HHS / CA / CA078038-040004; United States / NCI NIH HHS / CA / CA067360-09; United States / NCI NIH HHS / CA / R01 CA067360-09; United States / NCI NIH HHS / CA / R01 CA067360; United States / NCI NIH HHS / CA / CA78038
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen
  • [Other-IDs] NLM/ NIHMS24071; NLM/ PMC2039892
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4. Jeda A, Karoń J, Rak M: [The nodule of the small intestine--a rare case of benign metastasizing leiomyoma]. Ginekol Pol; 2009 Sep;80(9):716-9
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  • [Title] [The nodule of the small intestine--a rare case of benign metastasizing leiomyoma].
  • [Transliterated title] Guzek jelita cienkiego--rzadki przypadek mieśniaka przerzutowego (benign metastasizing leiomyoma).
  • The diagnosis of benign metastasizing leiomyoma BML is a casuic case.
  • The term is used to describe a entity of neoplasms characterized by a proliferation of smooth muscle cells with low mitotic index, usually located outside female genital organs.
  • In the world literature there are reports of benign metastasizing leiomyomas in the lungs, skull base and spine, the lymph nodes of the small pelvis and the heart.
  • In the following study the authors analyzed a case of a 72-year-old woman in which, during hysterectomy due to uterine leiomyomas, a nodule of the small intestine was found, confirmed histologically as leiomyoma.
  • [MeSH-major] Ileal Neoplasms / secondary. Leiomyoma / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Humans. Hysterectomy. Intestine, Small. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 19886249.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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5. Sailer J, Zacherl J, Schima W: MDCT of small bowel tumours. Cancer Imaging; 2007;7:224-33
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  • [Title] MDCT of small bowel tumours.
  • Primary benign and malignant neoplasm of the small bowel are rare.
  • Early detection of small bowel neoplasms is desirable but challenging for both clinicians and radiologists.
  • Conventional double contrast enteroclysis was the method of choice in small bowel imaging but is increasingly being replaced by cross-sectional imaging methods as computed tomography (CT) and magnetic resonance imaging (MRI).
  • Multidetector CT (MDCT) produces high-resolution cross-sectional imaging of the abdomen and the small bowel.
  • It allows multiplanar visualisation of small bowel tumours, demonstrates signs of small bowel obstruction as well as the mural and extramural extent of small bowel malignancies.
  • The best visualisation of small bowel neoplasms is achieved with CT enteroclysis or enterography and this review discusses these techniques and MDCT characteristics of small bowel tumours.
  • [MeSH-major] Gastrointestinal Neoplasms / radiography. Intestine, Small. Tomography, X-Ray Computed / methods

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  • (PMID = 18083648.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 30
  • [Other-IDs] NLM/ PMC2151330
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6. Kim SY, Jeon TJ, Hong JH, Kim GS, Oh TH, Seo DD, Shin WC, Choi WC: [An adult case of small bowel intussusception caused by hemangioma presenting with intestinal bleeding]. Korean J Gastroenterol; 2008 Sep;52(3):183-7
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  • [Title] [An adult case of small bowel intussusception caused by hemangioma presenting with intestinal bleeding].
  • Unlike childhood intussusception, adult intussusception has an identifiable leading lesion such as malignant or benign neoplasm.
  • There were few cases of small bowel intussusception caused by hemangioma in adults, but those reports were presented with abdominal pain.
  • This report describes a 65-year-old female who suffered from small bowel intussusception caused by hemangioma presenting with intestinal bleeding.
  • Abdominal computed tomography showed the target sign of small bowel with a leading point of mass.
  • This mass turned out to be a hemangioma after the small bowel resection.
  • Therefore, small bowel intussusception by hemangioma should be also considered as a bleeding focus when an adult patient presented intestinal bleeding without bleeding focus in the stomach and colon.
  • Herein we report a case of small bowel intussusception caused by hemangioma presenting with intestinal bleeding.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Hemangioma / complications. Intestinal Neoplasms / complications. Intestine, Small. Intussusception / diagnosis

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  • (PMID = 19077515.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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7. Yiğitler C, Ataç K, Yiğit T, Güleç B, Balkan M, Oner K: [A rare cause of bleeding intestinal intussusception in adult: jejunal lipoma]. Ulus Travma Acil Cerrahi Derg; 2007 Jul;13(3):237-40
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  • [Title] [A rare cause of bleeding intestinal intussusception in adult: jejunal lipoma].
  • [Transliterated title] Erişkinde nadir bir intestinal intussusepsiyon ve kanama nedeni: Jejunal lipom.
  • Small bowel neoplasms are usually diagnosed when patients are referred with complications such as hemorrhage or obstruction.
  • Intestinal lipomas are the third most frequent benign tumors among all intestinal neoplasms and their definite diagnosis is usually obtained after histopathological examination of the resected specimen.
  • A 76 year-old male patient with partial intestinal obstruction and rectal bleeding at admittance was found to have an abdominal mass on ultrasound.
  • The diagnosis of lipoma was confirmed with histopathological examination of the mass removed by an elective intestinal resection.
  • This case was reported as the intestinal lipoma leading a jejunojejunal intussusception associated with bleeding, could be diagnosed preoperatively.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Intussusception / diagnosis. Intussusception / etiology. Jejunal Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 17978901.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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8. Chen CY, Lin XZ, Wu HC, Shiesh SC: The value of biliary amylase and Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in diagnosing biliary malignancies. Clin Biochem; 2005 Jun;38(6):520-5
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  • [Title] The value of biliary amylase and Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in diagnosing biliary malignancies.
  • BACKGROUND/OBJECTIVES: Elevated concentrations of Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in pancreatic juice have been reported in patients with pancreatic adenocarcinoma and have been considered as a promising tumor marker.
  • At a cut-off value of 46 U/L, the biliary amylase distinguished patients with malignant obstruction from those with benign obstruction with a sensitivity of 66% and a specificity of 74%.
  • The divergent extent and duration of biliary obstruction caused by neoplasm and gallstones may contribute to the significant difference in the amylase activity in bile.
  • [MeSH-major] Amylases / analysis. Antigens, Neoplasm / analysis. Bile / enzymology. Bile Duct Neoplasms / diagnosis. Biomarkers, Tumor / analysis. Lectins, C-Type / analysis
  • [MeSH-minor] Biliary Tract Diseases / diagnosis. Diagnosis, Differential. Female. Humans. Male. Retrospective Studies. Taiwan

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  • (PMID = 15885230.001).
  • [ISSN] 0009-9120
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Lectins, C-Type; 0 / pancreatitis-associated protein; EC 3.2.1.- / Amylases
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9. Mortuaire G, Pasquesoone X, Leroy X, Chevalier D: Respiratory epithelial adenomatoid hamartomas of the sinonasal tract. Eur Arch Otorhinolaryngol; 2007 Apr;264(4):451-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Respiratory epithelial adenomatoid hamartomas of the sinonasal tract.
  • We report the clinicopathologic features of two cases of respiratory epithelial adenomatoid harmartoma (REAH) of the sinonasal tract.
  • The two patients were evaluated by a gastroenterologist to assess intestine colocalization.
  • Fine histopathological analysis is necessary to avoid aggressive surgery for this benign lesion.
  • [MeSH-major] Adenomatoid Tumor / pathology. Hamartoma / pathology. Paranasal Sinus Neoplasms / pathology. Respiratory Mucosa / pathology
  • [MeSH-minor] Adult. Endoscopy. Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 May;97(5):607-12 [15153874.001]
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  • (PMID = 17089137.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. Majewska U, Banaś D, Braziewicz J, Góźdź S, Kubala-Kukuś A, Kucharzewski M: Trace element concentration distributions in breast, lung and colon tissues. Phys Med Biol; 2007 Jul 7;52(13):3895-911
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The concentrations of Fe, Cu, Zn and Se in cancerous and benign tissues of breast, lung and intestine (colon) have been determined.
  • Finally, the log-rank test has been applied to compare the elemental concentration distributions between cancerous and benign tissues of the same organ, between cancerous tissues and between benign tissues taken from different organs.
  • Comparing benign and malignant neoplastic tissues, statistically significant differences have been found between Fe and Se concentration distributions of breast as well as for Cu and Zn in the case of lung tissues and in the case of colon tissues for Zn.
  • The concentrations of all elements have been found to be statistically different in cancer tissues as well as in benign ones when comparing the different organs, i.e. groups 'breast-colon' and 'breast-lung'.
  • For benign tissues of lung and colon a statistically significant difference has been found only for Zn.
  • [MeSH-major] Breast / metabolism. Breast Neoplasms / metabolism. Colon / metabolism. Colonic Neoplasms / metabolism. Lung / metabolism. Lung Neoplasms / metabolism. Spectrometry, X-Ray Emission / methods. Trace Elements / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Iron / chemistry. Male. Middle Aged. Neoplasm Metastasis. Selenium / chemistry. Zinc / chemistry

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  • (PMID = 17664584.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Trace Elements; E1UOL152H7 / Iron; H6241UJ22B / Selenium; J41CSQ7QDS / Zinc
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11. Nahal A, Meterissian S: Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma. Am J Clin Oncol; 2009 Aug;32(4):353-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Soft tissue tumors with dual adipocytic and smooth muscle differentiation are generally rare with most being benign.
  • RESULTS: Based on the literature, lipoleiomyosarcomas favor body cavities and visceral sites although an occurrence in the intestine has been reported.
  • CONCLUSIONS: This is the first reported case of an intestinal lipoleiomyosarcoma.
  • [MeSH-major] Leiomyosarcoma / pathology. Liposarcoma / pathology. Neoplasm Invasiveness / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Colectomy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Middle Aged. Neoplasm Staging. Pelvic Pain / diagnosis. Pelvic Pain / etiology. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19363435.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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12. Sugár I, Forgács B, István G, Bognár G, Sápy Z, Ondrejka P: Gastrointestinal stromal tumors (GIST). Hepatogastroenterology; 2005 Mar-Apr;52(62):409-13
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  • [Title] Gastrointestinal stromal tumors (GIST).
  • BACKGROUND/AIMS: Gastrointestinal stromal tumors (GIST) are the most frequent non-epithelial tumors of the alimentary tract.
  • GIST's occur throughout the gastrointestinal tract but are generally located in the stomach and the intestine.
  • The tumor size, mitotic rate, cellularity and nuclear pleomorphism are the most important parameters characterizing the biological behavior of tumors.
  • The diagnostic procedures are similar to those of other gastrointestinal neoplasms but only a half of the patients will have correct preoperative histological diagnosis.
  • RESULTS: All but one proved to be benign.
  • CONCLUSIONS: GIST is a rare neoplasm of the GI tract.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Incidental Findings. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 15816446.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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13. Yimyaem P, Saranrittichai S, Sinawat P, Dhiensiri T: Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant. J Med Assoc Thai; 2009 Jan;92(1):114-9
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  • [Title] Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant.
  • Benign intestinal tumors are rare in children; however, the authors describe an inflammatory myofibroblastic tumor (IMT) of the terminal ileum in a 2-month-old infant who presented with an intestinal obstruction.
  • A review of the literature for this rare condition was done to delineate the natural history of this tumor and to do a histological confirmation of its benign nature.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Ileal Diseases / pathology. Intestinal Obstruction / pathology

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  • (PMID = 19260252.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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14. Coco C, Rizzo G, Manno A, Mattana C, Verbo A: Surgical treatment of small bowel neoplasms. Eur Rev Med Pharmacol Sci; 2010 Apr;14(4):327-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of small bowel neoplasms.
  • Small intestinal neoplasms are uncommon cancers.
  • Benign small intestinal tumors (e.g., leiomyoma, lipoma, hamartoma, or desmoid tumor) usually are asymptomatic but may present with complications.
  • Primary malignancies of the small intestine, including adenocarcinoma, leiomyosarcoma, carcinoid, and lymphoma, are often symptomatic and may present with intestinal obstruction, jaundice, bleeding, or pain.
  • Metastatic neoplasms may involve the small intestine via contiguous spread, peritoneal metastases or hematogenous metastases.
  • Because the small intestine is relatively inaccessible to routine endoscopy, diagnosis of small intestinal neoplasms is often delayed for months after onset of symptoms.
  • During last years the increase of small bowel endoscopy and other diagnostic tools allow earlier non-operative diagnosis.
  • Even though radical resection of small bowel cancer plays an important role, the 5 yr overall survival remains low.
  • [MeSH-major] Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery. Humans. Laparoscopy. Lymphoma / pathology. Lymphoma / surgery. Neoplasm Metastasis

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  • (PMID = 20496543.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 51
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15. Amosenko FA, Korchagina EL, Matveeva TI, Vaganov IuE, Vlasov SB, Poltavets NV, Veselov VV, Gar'kavtseva RF, Poliakov AV: [Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]. Genetika; 2010 May;46(5):700-8
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  • To estimate diagnostic value of K-ras mutations during cancer risk group formation, they were studied in the samples of sporadic carcinomas (n = 33) and malignant (n = 13) polyps of large intestine obtained during surgery or polypectomy.
  • Mutation frequency in carcinomas, benign and malignant polyps was 43, 49, and 69%, respectively.
  • In the healthy tissue of the large intestine, no changes in codons 12 and 13 in the K-ras gene were observed.
  • In patients with colorectal carcinoma the mutation frequency in the K-ras gene was not associated with disease onset age, location, and the extent of tumor differentiation while it was associated with the stage of tumor process.
  • The maximum mutation frequency was revealed in polyps of patients over 70 years of age as well as in the adenomas of villous histology and large size ((1 cm).
  • [MeSH-major] Adenocarcinoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Neoplasm / genetics. Genes, ras / genetics. Mutation

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  • (PMID = 20583607.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Codon; 0 / DNA, Neoplasm
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16. Willis S, Schumpelick V: [Open colon surgery]. Chirurg; 2005 Nov;76(11):1073-81
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  • The surgical aim is resection of the affected intestinal region and the according lymph drainage region.
  • In case of benign underlying disease, the operational method depends largely on the extent to which the intestine is affected and can include anything from simple colotomy and polyp removal to colectomy for toxic megacolon.
  • [MeSH-major] Colectomy / methods. Colorectal Neoplasms / surgery. Lymph Node Excision / methods. Sigmoid Neoplasms / surgery
  • [MeSH-minor] Anastomosis, Surgical / methods. Colon / pathology. Colonic Polyps / mortality. Colonic Polyps / pathology. Colonic Polyps / surgery. Humans. Neoplasm Invasiveness / pathology. Neoplasm Staging. Postoperative Complications / mortality. Surgical Staplers. Surgical Wound Dehiscence / mortality. Survival Analysis. Suture Techniques

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  • [Cites] Br J Surg. 1988 May;75(5):409-15 [3292002.001]
  • [Cites] Dis Colon Rectum. 2004 Mar;47(3):271-7; discussion 277-8 [14991487.001]
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  • [Cites] Chirurg. 2004 Nov;75(11):1071-8 [15316639.001]
  • (PMID = 16240155.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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17. Van Weyenberg SJ, Meijerink MR, Jacobs MA, Van der Peet DL, Van Kuijk C, Mulder CJ, Van Waesberghe JH: MR enteroclysis in the diagnosis of small-bowel neoplasms. Radiology; 2010 Mar;254(3):765-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR enteroclysis in the diagnosis of small-bowel neoplasms.
  • PURPOSE: To evaluate the diagnostic accuracy and interobserver variance of magnetic resonance (MR) enteroclysis in the diagnosis of small-bowel neoplasms, with small-bowel endoscopy, surgery, histopathologic analysis, and follow-up serving as standards of reference, and to identify MR enteroclysis characteristics capable of enabling discrimination between benign and malignant small-bowel neoplasms.
  • Only studies explicitly performed to investigate or exclude the presence of small-bowel neoplasms were included.
  • Tumor characteristics were compared with the Student t test and the Fisher exact test.
  • RESULTS: Readers 1 and 2 interpreted 31 and 33 studies, respectively, as depicting a small-bowel neoplasm and 19 and 17 studies, respectively, as depicting small-bowel malignancy.
  • In 32 patients, the presence of small-bowel neoplasm was confirmed.
  • In 19 of these patients, the neoplasm was malignant.
  • Sensitivity and specificity in the diagnosis of small-bowel neoplasms was 0.91 and 0.95, respectively, for reader 1 and 0.94 and 0.97, respectively, for reader 2; the kappa value was 0.95.
  • CONCLUSION: Eighty-six of 91 studies were correctly interpreted, resulting in an overall diagnostic accuracy of 0.95 for MR enteroclysis in the detection of small-bowel neoplasms.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small. Magnetic Resonance Imaging / methods

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  • [Copyright] (c) RSNA, 2010
  • (PMID = 20177091.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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18. Kelly RJ, Barrett C, Swan N, McDermott R: Metastatic phyllodes tumor causing small-bowel obstruction. Clin Breast Cancer; 2009 Aug;9(3):193-5
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  • [Title] Metastatic phyllodes tumor causing small-bowel obstruction.
  • Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas.
  • Metastases to the small intestine are extremely rare, with only 1 case of metastatic spread to the duodenum reported in the literature.
  • This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction.
  • Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems.
  • The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Ileal Neoplasms / secondary. Intestinal Obstruction / etiology. Phyllodes Tumor / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19661046.001).
  • [ISSN] 1938-0666
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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19. Anurova OA, Snigur PV, Filippova NA, Sel'chuk VIu: [Morphological characteristics of stromal gastrointestinal tumors]. Arkh Patol; 2006 Jan-Feb;68(1):10-3
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  • [Title] [Morphological characteristics of stromal gastrointestinal tumors].
  • Stromal tumors are singled out from smooth muscle and neurogenic neoplasms into a special group due to differences in CD117 expression caused by mutation of c-kit gene.
  • Out of 57 stromal tumors, 37 (64,9%) located in the stomach, 17 (29,8%) in the small intestine and 3 (5,3%) in the colon.
  • Immunohistochemically, all the tumors expressed CD117 and vimentine.
  • Smooth muscle actin was found in 82% tumors, S-100 protein in 75%, neuron-specific enolase in 66% cases.
  • Malignant tumors were in 93% cases, and in 7% benign.
  • [MeSH-major] Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology. Neoplasm Proteins / biosynthesis
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Liver Neoplasms / metabolism. Liver Neoplasms / mortality. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Male. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / mortality. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 16544528.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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20. Siddique K, Bhandari S, Basu S: Giant mesenteric lymphangioma: a rare cause of a life-threatening complication in an adult. BMJ Case Rep; 2010;2010
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  • Mesenteric cyst lymphangiomas (MCLs) are rare benign tumours of unknown aetiology seen mostly in children.
  • [MeSH-major] Intestinal Obstruction / etiology. Intestine, Small / surgery. Lymphangioma, Cystic / pathology. Mesenteric Cyst / pathology. Mesentery / pathology. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Abdomen, Acute / diagnosis. Abdomen, Acute / etiology. Anastomosis, Surgical. Critical Illness. Follow-Up Studies. Humans. Magnetic Resonance Imaging / methods. Male. Neoplasm Invasiveness / pathology. Neoplasm Staging. Rare Diseases. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Vomiting / diagnosis. Vomiting / etiology. Young Adult

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  • (PMID = 22778193.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
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21. Strobel K, Haerle SK, Stoeckli SJ, Schrank M, Soyka JD, Veit-Haibach P, Hany TF: Head and neck squamous cell carcinoma (HNSCC)--detection of synchronous primaries with (18)F-FDG-PET/CT. Eur J Nucl Med Mol Imaging; 2009 Jun;36(6):919-27
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of the 56 second cancers, 46 (82%) were found in the aerodigestive tract in the following locations: lung (26, 46%), head and neck (15, 17%), oesophagus (5, 9%).
  • Ten second cancers (18%) were located outside the aerodigestive tract (colon, five; stomach, lymphoma, breast, thymus and kidney, one each).
  • False-positive PET/CT findings were mainly related to benign FDG uptake in the intestine due to benign or precancerous polyps or physiological FDG uptake in other head and neck regions.
  • Synchronous cancers were predominantly located in the aerodigestive tract, primarily in the lung, head and neck and oesophagus.
  • [MeSH-major] Fluorodeoxyglucose F18. Head and Neck Neoplasms / diagnostic imaging. Neoplasms, Multiple Primary / diagnostic imaging. Neoplasms, Squamous Cell / diagnostic imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. False Positive Reactions. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / diagnostic imaging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19205699.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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22. Orlandi M, Inauen W: [Chronic gastrointestinal bleeding]. Ther Umsch; 2006 May;63(5):327-32
MedlinePlus Health Information. consumer health - Gastrointestinal Bleeding.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Occult bleeding from the gastrointestinal tract is typically identified by either a positive stool test for occult blood or by the presence of iron deficiency anemia.
  • The major cause of iron deficiency anemia is blood loss from the gastrointestinal tract.
  • In most of these patients, the bleeding source responsible for the chronic blood loss is located in the small bowel.
  • The most common cause for gastrointestinal bleeding of small bowel origin is angiodysplasia, tumors of the small intestine (primary benign or malignant tumors or metastatic lesions) and various other causes (such as ulcers caused by nonsteroidal antiinflammatory drugs, aortoenteric fistula, diverticula, endometriosis and hemobilia).
  • After negative upper and lower endoscopy, examination of the small bowel is warranted.
  • Methods to evaluate the small bowel include enteroscopy, capsule endoscopy, small bowel radiographic studies and angiography.
  • Explorative surgery with intraoperative enteroscopy is generally reserved for patients with ongoing transfusion requirement and in those under the age of 5O years (to rule out a small bowel neoplasm).

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  • (PMID = 16739891.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 6
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23. Sulentić P, Abdović S, Filipović J, Tomas D: Pedunculated myolipoma incidentally found in hernial sac: a case report. Acta Clin Croat; 2009 Jun;48(2):171-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of a very rare adipocytic tumor found during corrective surgery for incisional abdominal hernia is presented.
  • During surgery of incisional hernia, a part of small intestine along with a pedunculated tumor was found in hernial sac.
  • The tumor was attached to the medial intra-abdominal peritoneum.
  • On examination, the tumor presented as a totally encapsulated dimorphic benign neoplasm composed of mature adipocytes and well-differentiated smooth muscle cells.
  • Tumor cells were negative for HMB45, estrogen and progesterone.
  • This tumor commonly presents as a large quiescent mass in retroperitoneum in adult females and to our knowledge this is the first report of myolipoma in hernial sac.
  • Characteristic findings, differential diagnosis, prognosis and the possible origin of such a neoplasm are discussed.
  • [MeSH-major] Hernia, Abdominal / surgery. Lipoma / diagnosis. Peritoneal Neoplasms / diagnosis

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  • (PMID = 19928417.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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24. Salem PA, Estephan FF: Immunoproliferative small intestinal disease: current concepts. Cancer J; 2005 Sep-Oct;11(5):374-82
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for immunoproliferative small intestinal disease .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoproliferative small intestinal disease: current concepts.
  • Immunoproliferative small intestinal disease is a distinctive lymphoproliferative disorder.
  • Among these disorders, it is the only disease associated with a specific and characteristic abnormal protein, and also an identifiable, at least in some patients, early phase with a benign-looking histo-pathologic expression.
  • In contrast to primary nonimmunoproliferative small intestinal lymphomas, in which the pathology in the intestine is usually focal and involving specific segments of the intestine and leaving the segments between the involved areas free of disease, the pathology in immunoproliferative small intestinal disease is diffuse, with a mucosal cellular infiltrate involving large segments of the intestine and sometimes the entire length of the intestine, thus producing malabsorption.
  • Additional research is indicated not only to understand this specific lymphoproliferative disorder but also to understand lymphomas in general.
  • [MeSH-major] Immunoproliferative Small Intestinal Disease
  • [MeSH-minor] Humans. Laparotomy. Neoplasm Staging. Prognosis

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  • (PMID = 16259867.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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25. Majeski J: Endoscopic capsule retention in an intestinal anastomosis. Int Surg; 2009 Jul-Sep;94(3):254-7
MedlinePlus Health Information. consumer health - Intestinal Obstruction.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic capsule retention in an intestinal anastomosis.
  • CE has become a first line method of evaluating the small intestine for suspected abnormalities and disease.
  • Contraindications to CE include the presence of intestinal obstruction, fistulas, or structures.
  • Capsule retention has been reported in patients with a strictured or stenotic area of intestine caused by occult neoplasm, nonsteroidal anti-inflammatory drugs, Crohn's disease, radiation enteritis, or previous abdominal surgery.
  • Safe and effective use of CE has been reported in the evaluation of patients who have previously undergone surgical resection of the small intestine for benign or malignant disease.
  • This case report reviews the utilization and subsequent retention of an endoscopic capsule in a symptomatic patient who had a previous small bowel resection caused by the sequelae of radiation therapy to the abdomen and pelvis for endometrial cancer.
  • The resected segment of small intestine contained the endoscopic capsule, previous intestinal anastomosis, recurrent bowel strictures secondary to radiation enteritis, and a chronic ulcerated intestinal lumen caused by the retained endoscopic capsule.
  • This case report shows that use of CE cannot always be considered safe in patients who have had a previous surgical intestinal anastomosis.
  • CE should not be used in patients who have had a previous small bowel resection and anastomosis for symptomatic intestinal structures that developed because of radiation enteritis.
  • [MeSH-major] Capsule Endoscopy / adverse effects. Endometrial Neoplasms / surgery. Foreign Bodies / complications. Foreign Bodies / surgery. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Intestine, Small / surgery

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  • (PMID = 20187521.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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26. Schöniger S, Summers BA: Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken. Vet Pathol; 2009 Sep;46(5):904-15

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors.
  • In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established.
  • We describe peripheral nerve sheath tumors with microscopic, immunohistologic, and ultrastructural features similar to those in subtypes of human neurofibroma in 12 dogs, 2 horses, and 1 chicken.
  • The canine tumors were located in the skin, peripheral nerve, tongue, and large intestine.
  • The equine tumors were located in the subcutis of the neck and axilla.
  • The chicken was a mature white Leghorn chicken with an ocular neoplasm.
  • Two plexiform neurofibromas occurred together with diffuse ganglioneuromatosis in the large intestine of young dogs, as has also been reported in humans.
  • This investigation shows the existence of identical subtypes of neurofibroma in animals and humans and identifies similarities in tumor location and patient age between animals and humans.
  • This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.

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  • (PMID = 19429995.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Coste I, Freund JN, Spaderna S, Brabletz T, Renno T: Precancerous lesions upon sporadic activation of beta-catenin in mice. Gastroenterology; 2007 Apr;132(4):1299-308
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND & AIMS: Inappropriate activation of beta-catenin in adult tissues is associated with a wide variety of cancers, especially in the digestive tract.
  • Classic transgenic and knockout murine models in which beta-catenin is activated in large fields of cells have provided experimental support in favor of a role for this molecule in tumorigenesis.
  • No lesion was detected in the intestine or in the liver.
  • In addition, one third of female mutant mice developed benign perimammary papillomas.
  • CONCLUSIONS: These results challenge the view that activation of beta-catenin induces malignant cancerogenesis, because they show in mice that sporadically activated beta-catenin is sufficient for tumor initiation, yet without further malignant progression, and that it sensitizes cells to environmental hits.
  • This model represents a powerful tool to investigate the interplay between genetic and environmental factors in tumor progression.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Precancerous Conditions / pathology. RNA, Neoplasm / genetics. Skin Neoplasms / pathology. Stomach Neoplasms / pathology. beta Catenin / genetics
  • [MeSH-minor] Animals. Cell Line, Tumor. Disease Progression. Female. Immunohistochemistry. Mice. Mice, Inbred C57BL. Mice, Knockout. Neoplasms, Experimental. Phenotype. Polymerase Chain Reaction. Pregnancy

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • MedlinePlus Health Information. consumer health - Stomach Cancer.
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  • (PMID = 17408631.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 0 / beta Catenin
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