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1. Baba Y, Kato Y, Ogawa K: Hyperplasia of lymphoid structures in the hypopharynx: a case report. J Med Case Rep; 2010;4:388

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperplasia of lymphoid structures in the hypopharynx: a case report.
  • INTRODUCTION: Ectopic tonsillar tissue simulating a benign tumor of the hypopharynx is described in this report.
  • Because clinical observation revealed benign features, tumor tissue was laryngoscopically resected.
  • CONCLUSIONS: Although ectopic tonsillar tissue of the hypopharynx is relatively rare, it should be kept in mind during differential diagnosis.

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  • (PMID = 21118489.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3002377
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2. Luna-Ortiz K, Campos-Ramos E, Carmona-Luna T, Mohar-Betancourt A, Ferrari-Carballo T: Laser resection of liposarcoma of the hypopharynx. Med Oral Patol Oral Cir Bucal; 2009 May;14(5):E252-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laser resection of liposarcoma of the hypopharynx.
  • Primary liposarcoma of the hypopharynx (piriform sinus) is extremely rare.
  • The tumor recurred 4 years postoperatively and the patient was again surgically intervened using the same approach.
  • [MeSH-major] Hypopharyngeal Neoplasms / surgery. Laser Therapy. Liposarcoma / surgery

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  • (PMID = 19218900.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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3. Wang SH, Yang XM, Zeng YC, He XB, Dong ZG, Yu FL, Qi HZ, Zhou JP, Xiao ZA, Tang QL, Yang S, Xie DH: [Reconstructive methods for hypopharynx and cervical esophagus]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2007 Jun;32(3):524-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Reconstructive methods for hypopharynx and cervical esophagus].
  • OBJECTIVE: To review the surgical treatment for reconstructing hypopharynx and cervical esophagus after hypopharyngo-oesophagectomy, and to evalue its efficacy.
  • METHODS: Different methods were adopted to reconstruct the hypopharynx and cervical esophagus among 25 cases, including 14 cases of carcinoma of the hypopharynx and 11 of carcinoma of hypopharynx and cervical esophagus.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagoplasty / methods. Hypopharyngeal Neoplasms / surgery. Hypopharynx / surgery

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  • (PMID = 17611339.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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4. Popescu CR, Bertesteanu SV, Mirea D, Grigore R, lonescu D, Popescu B: The epidemiology of hypopharynx and cervical esophagus cancer. J Med Life; 2010 Oct-Dec;3(4):396-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The epidemiology of hypopharynx and cervical esophagus cancer.
  • At the beginning of the 21st century the hypopharynx and the cervical esophagus cancer represents a major issue for all countries of the world.
  • The epidemiology of the hypopharynx and cervical esophagus cancer deals with the spread of the disease in the human population with regard to sex, age, profession, time and space, as well as risk factors that contribute to these phenomena.
  • The epidemiology of the hypopharynx and cervical esophagus cancer includes three major areas of interest: descriptive (the study of the spread in mass population), analytical (the study of causal risk factors on the disease) and experimental (that verifies by experiments on animals the prior identified hypothesis).
  • [MeSH-major] Alcohol Drinking / epidemiology. Asbestosis / epidemiology. Esophageal Neoplasms / epidemiology. Hypopharyngeal Neoplasms / epidemiology. Registries / statistics & numerical data
  • [MeSH-minor] Animals. Female. Genetic Predisposition to Disease / epidemiology. Humans. Hypopharynx. Male. Patient Care Team. Risk Assessment. Risk Factors

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  • (PMID = 21254737.001).
  • [ISSN] 1844-122X
  • [Journal-full-title] Journal of medicine and life
  • [ISO-abbreviation] J Med Life
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3019060
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5. Nemec SF, Formanek M, Noebauer-Huhmann IM, Krestan CR, Frühwald J, Peloschek P, Herneth AM, Czerny C: [Pathological changes of the hypopharynx in the focus of imaging]. Radiologe; 2009 Jan;49(1):36-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pathological changes of the hypopharynx in the focus of imaging].
  • [Transliterated title] Pathologische Veränderungen des Hypopharynx im Brennpunkt der Bildgebung.
  • The spectrum of pathological changes in anatomical sections of the hypopharynx ranges from benign pathologies to hypopharyngeal carcinoma.
  • Especially in radiological oncology, it is extremely important in regions which are clinically difficult to assess to determine the exact localization and extent of hypopharyngeal pathologies to plan the optimal therapy for the patient.
  • This article demonstrates the radiological appearance of pathological changes of the hypopharynx and discusses in particular the hypopharynx carcinoma in the focus of pre-therapeutic and post-therapeutic imaging.
  • [MeSH-major] Hypopharyngeal Neoplasms / diagnosis. Hypopharynx / pathology. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Pharyngeal Diseases / diagnosis. Positron-Emission Tomography
  • [MeSH-minor] Contrast Media / administration & dosage. Humans. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Tomography, Spiral Computed. Zenker Diverticulum / diagnosis. Zenker Diverticulum / pathology

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  • (PMID = 19023556.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 36
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6. I H, Kim JS, Shim YM: Giant fibrovascular polyp of the hypopharynx: surgical treatment with the biappoach. J Korean Med Sci; 2006 Aug;21(4):749-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant fibrovascular polyp of the hypopharynx: surgical treatment with the biappoach.
  • Fibrovascular polyps of the esophagus and hypopharynx are benign tumors of the upper digestive tract.
  • The majority of these polyps are located in the upper part of the esophagus but the hypopharyngeal fibrovascular polyps are only rarely seen.
  • The authors report here on a case of a 63-yr-old-man with a giant fibrovascular polyp of the hypopharynx that extended into the stomach; this polyp was removed through simultaneous transcervical and transabdominal approaches because of the huge size of the polyp.
  • [MeSH-major] Hypopharynx. Pharyngeal Diseases / diagnosis. Polyps / diagnosis

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  • (PMID = 16891825.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2729903
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7. Chedid HM, Franzi SA, Rapoport A, Curioni OA: Impact of combination therapy on disease free survival in hypopharynx cancer. Rev Col Bras Cir; 2010 Dec;37(6):385-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of combination therapy on disease free survival in hypopharynx cancer.
  • OBJECTIVE: To evaluate the disease-free survival in hypopharyngeal tumors submitted to postoperative radiotherapy.
  • CONCLUSION: The initial manifestation of squamous cell carcinoma of the hypopharynx happens in advanced stages (III and IV), with superior five-year disease-free survival in clinical stage III.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Hypopharyngeal Neoplasms / therapy

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  • (PMID = 21340251.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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8. Latoo M, Lateef M, Khan M, Majid S, Islam MS, Ali J, Nawaz I, Ahmed S: Angiolipoma of hypopharynx: A diagnostic dilemma. Indian J Otolaryngol Head Neck Surg; 2007 Jun;59(2):176-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiolipoma of hypopharynx: A diagnostic dilemma.
  • We present a 48-year-old male with fibrovascular polyp of hypopharynx.
  • Diagnosis was established by barium swallow and oesophagoscopy.Transoral route was used to remove the polyp and histopathology reported as angiolipoma.

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  • (PMID = 23120425.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451778
  • [Keywords] NOTNLM ; Barium swallow / Fibrovascular polyp / Regurgitation / Videoendoscopy
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9. Franzen A, Theegarten D: [Carcinosarcoma of the larynx and hypopharynx]. Laryngorhinootologie; 2007 Mar;86(3):209-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinosarcoma of the larynx and hypopharynx].
  • [Transliterated title] Karzinosarkome des Larynx und Hypopharynx.
  • INTRODUCTION: A carcinosarcoma is an uncommon neoplasm with both malignant epithelial and malignant mesenchymal components.
  • The tumor entity has been described in many epithelial organs.
  • Manifestation in the larynx and the hypopharynx is rare.
  • PATIENTS: This report recounts two patients, one with a carcinosarcoma of the vocal cords and the other with a hypopharynx tumour.
  • DISCUSSION: Carcinosarcomas of the larynx and hypopharynx are typically described in elderly men.
  • Crucial for the diagnosis is the revelation of a carcinoma together with sarcoma in the histology and immunohistochemistry both in the primary and secondary side.
  • The histogenesis of carcinosarcoma is not yet clear--it seems that a pluripotent cell produces both tumour components.
  • Despite of an often large tumor volume the preservation of the larynx seems to be possible in many cases, because exophytic tumours are pre-potent.
  • [MeSH-major] Carcinosarcoma. Hypopharyngeal Neoplasms. Laryngeal Neoplasms. Vocal Cords
  • [MeSH-minor] Endoscopy. Follow-Up Studies. Humans. Hypopharynx / pathology. Hypopharynx / surgery. Immunohistochemistry. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17410642.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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10. Schlottmann A, Witt G, Dahl R, Kleemann D, Glass A: [24-hour pH monitoring of the hypopharynx in 545 patients with special regard to a critical data evaluation]. Laryngorhinootologie; 2006 Aug;85(8):573-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [24-hour pH monitoring of the hypopharynx in 545 patients with special regard to a critical data evaluation].
  • [Transliterated title] Ergebnisse der 24-Stunden-pH-Metrie des Hypopharynx von 545 Patienten unter besonderer Berücksichtigung einer kritischen Auswertung.
  • BACKGROUND: Although a number of reports exist on 24-hour pH monitoring of the hypopharynx, no consensus has been reached about evaluation standards.
  • [MeSH-major] Gastric Acidity Determination / instrumentation. Gastroesophageal Reflux / diagnosis. Hypopharynx / physiology. Monitoring, Ambulatory / instrumentation

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  • (PMID = 16755458.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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11. Bak NB, Rasmussen N: [Mediastinal abscess caused by self-mutilation of the hypopharynx]. Ugeskr Laeger; 2010 May 24;172(21):1609-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mediastinal abscess caused by self-mutilation of the hypopharynx].
  • [Transliterated title] Mediastinal absces forårsaget af selvmutilering i hypopharynx.
  • [MeSH-major] Abscess / etiology. Hypopharynx / injuries. Mediastinitis / etiology. Self Mutilation / complications

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  • (PMID = 20525475.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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12. Bernal-Sprekelsen M, Dazert S, Sudhoff H, Blanch JL, Vilaseca I: [Complications of transoral laser surgery for malignant tumors of the larynx and hypopharynx]. Laryngorhinootologie; 2009 Jan;88(1):28-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Complications of transoral laser surgery for malignant tumors of the larynx and hypopharynx].
  • [Transliterated title] Komplikationen in der transoralen Laserchirurgie maligner Tumoren des Larynx und Hypopharynx.
  • [MeSH-major] Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / surgery. Laryngoscopy. Laser Therapy. Postoperative Complications / etiology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Pneumonia, Aspiration / etiology. Postoperative Hemorrhage / etiology. Reoperation. Risk Factors

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  • (PMID = 19205077.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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13. Nishimura G, Sano D, Hanashi M, Yamanaka S, Tanigaki Y, Taguchi T, Horiuchi C, Matsuda H, Mikami Y, Tsukuda M: Myxofibrosarcoma of the hypopharynx. Auris Nasus Larynx; 2006 Mar;33(1):93-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxofibrosarcoma of the hypopharynx.
  • Hypopharyngeal myxofibrosarcoma has not been reported previously.
  • We report the first case of a patient with myxofibrosarcoma of the hypopharynx.
  • Sarcomas are rare in the hypopharynx, but we have to bear in mind their possibility.
  • [MeSH-major] Fibrosarcoma / pathology. Hypopharyngeal Neoplasms / pathology

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  • (PMID = 16183234.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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14. Fritzsche K, Breitenstein K, Esser D: [Patients with malignancies of the oro- and hypopharynx as well as the larynx. Significance/importance of oncological aftercare consultation]. HNO; 2010 Aug;58(8):756-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Patients with malignancies of the oro- and hypopharynx as well as the larynx. Significance/importance of oncological aftercare consultation].
  • [Transliterated title] Patienten mit Malignomen des Oro- und Hypopharynx sowie Larynx. Stellenwert der onkologischen Nachsorgesprechstunde.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / therapy. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / therapy. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Second Primary / diagnosis. Oropharyngeal Neoplasms / diagnosis. Oropharyngeal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Cooperative Behavior. Disease Progression. Endoscopy. Female. Humans. Interdisciplinary Communication. Male. Middle Aged. Neoplasm Staging. Patient Care Team. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 20694544.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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15. Koscielny S, Gottschall R: [Perforation of the hypopharynx as a rare life-threatening complication of endotracheal intubation]. Anaesthesist; 2006 Jan;55(1):45-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Perforation of the hypopharynx as a rare life-threatening complication of endotracheal intubation].
  • [Transliterated title] Die Perforation des Hypopharynx als seltene, lebensbedrohliche Komplikation der endotrachealen Intubation.
  • MATERIALS AND METHODS: Two cases of hypopharyngeal perforation after intubation are presented and discussed.
  • The other initially showed minor symptoms but increasing difficulties in swallowing led to the diagnosis of a retropharyngeal abscess.
  • CONCLUSIONS: Physicians performing endotracheal intubation or dealing with patients after intubation, should be aware of the clinical symptoms because only early diagnosis and therapy can prevent development of mediastinitis.
  • To prevent hypopharyngeal injury a thorough evaluation of the "difficult airway" and the atraumatic performance of direct laryngoscopy and endotracheal intubation are mandatory.
  • [MeSH-major] Hypopharynx / injuries. Intubation, Intratracheal / adverse effects

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  • (PMID = 16003544.001).
  • [ISSN] 0003-2417
  • [Journal-full-title] Der Anaesthesist
  • [ISO-abbreviation] Anaesthesist
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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16. Jecker P, Schuon R, Hlawatsch A: [Ultrasound of hypopharyngeal and oesophageal cancer: possibilities and limitations to staging and planning of therapy]. Ultraschall Med; 2005 Aug;26(4):312-7
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ultrasound of hypopharyngeal and oesophageal cancer: possibilities and limitations to staging and planning of therapy].
  • [Transliterated title] Die sonographische Beurteilbarkeit des Hypopharynx und des extrathorakalen Osophagus: Möglichkeiten und Grenzen für Staging und Therapieplanung.
  • Sonographic examination of the hypopharynx and the extrathoracic oesophagus can be difficult.
  • The aim of the present prospective study was to demonstrate that the combination of ultrasonography and endoscopy provides a sufficient basis for the planning of surgical interventions in patients suffering from hypopharyngeal cancer or cancer of the proximal oesophagus.
  • In 10 patients with squamous cell carcinoma of the hypopharynx/proximal oesophagus (8T4, 2T2) and 2 patients with a T4 squamous cell carcinoma of the larynx, both preoperative CT and ultrasound were performed and compared with the extent of the tumour seen during endoscopy.
  • With ultrasound, the T4 tumours of the hypopharynx were recognized well as opposed to the T2 tumours which were not detected.
  • In contrast to CT, intralaryngeal tumour spread was not seen with ultrasound as long as the laryngeal skeleton was intact.
  • Nevertheless, these results show that in all patients included in this study the extent of the tumour could have been estimated correctly by using ultrasound plus endoscopic examination alone.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Carcinoma, Squamous Cell / ultrasonography. Esophageal Neoplasms / therapy. Esophageal Neoplasms / ultrasonography. Hypopharyngeal Neoplasms / therapy. Hypopharyngeal Neoplasms / ultrasonography
  • [MeSH-minor] Female. Humans. Male. Neoplasm Staging. Reproducibility of Results. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Hypopharyngeal cancer.
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  • (PMID = 16123926.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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17. Mesia R, Vázquez S, Grau JJ, García-Sáenz JA, Bayona C, Galceran JC, Irigoyen A, Lozano A, Mañós M, Cruz JJ, Spanish Head and Neck Cancer Research Group: A single-arm phase II trial to evaluate the combination of cetuximab plus docetaxel, cisplatin, and 5-fluorouracil (TPF) as induction chemotherapy (IC) in patients (pts) with unresectable SCCHN. J Clin Oncol; 2009 May 20;27(15_suppl):6015

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary sites were: oropharynx, 23; hypopharynx, 16; oral cavity, 5; larynx, 4.41(82%) pts received all 4 cycles of cetuximab TPF; 47 pts received ≥2 C and were evaluable for response using RECIST.
  • 3 pts received <2 C (2 deaths from intercurrent disease and febrile neutropenia, 1 secondary neoplasm diagnosed).

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  • (PMID = 27962422.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Billan S, Abdah-Bortnyak R, Mezid F, Bernstein Z, Gez E, Nasrallah H, Kuten A: Neoadjuvant docetaxel, cisplatin, and 5-fluorouracil before concurrent chemoradiotherapy or concurrent cetuximab-radiotherapy in locally advanced squamous cell carcinoma of the head and neck. J Clin Oncol; 2009 May 20;27(15_suppl):e17045

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Between march 2007 and november 2008, 29 previously untreated patients (19 male and 4 female) with stage III-IV squamous cell carcinoma of the oral cavity, larynx, oropharynx, or hypopharynx were included to the study.

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  • (PMID = 27961767.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Bohlen G, Raabe A, Dahm-Daphi J, Dikomey E, Schild SE, Dunst J, Rades D: Development of a new micro-injection-system for adenoviral gene delivery (MAGD). J Clin Oncol; 2009 May 20;27(15_suppl):e22167

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Because the injection arms can be moved in x-,y- and z-direction, virus injection can easily performed for irregular tumor volumes.
  • The efficacy of the MAGD was tested in 4 human squamous cell carcinoma cell lines from oro-/hypopharynx (FaDu, UD- SCC2, UD-SCC6, and UD-SCC7a).

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  • (PMID = 27963674.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Castro G Jr, de Lima AG, Lopes DR, Ortegosa MV, Rosalmeida MC, Gil E, Cavalcanti Leal AI, Federico MH, Villar RC, Snitcovsky I: Oral mucositis prevention by low-level laser therapy in head and neck cancer patients submitted to concurrent chemoradiation: A prospective randomized study. J Clin Oncol; 2009 May 20;27(15_suppl):6019

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: 73 pts were included (77% male; mean age 53 y); primary site: oropharynx (31 pts), larynx (15), nasopharynx (10), hypopharynx (8), oral cavity (7 pts), UPS (2); 36 pts received prophylactic LLL.

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  • (PMID = 27962426.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Ferris RL, Feinstein T, Grandis J, Johnson R, Branstetter B, Gooding W, Argiris A: Serum biomarkers as predictors of clinical outcome after cetuximab-based therapy in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol; 2009 May 20;27(15_suppl):6035

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Median age 54 years (21-74); male: 27; stage IV: 29; primary site: oropharynx, 16; larynx, 4; hypopharynx, 3, nasopharynx, 3; oral cavity, 3; and unknown, 2.

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  • (PMID = 27961910.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Fayette J, Montella A, Bachelot T, Pommier P, Girodet D, Racadot S, Montbarbon X, Favier B, Zrounba P: Paclitaxel in relapsed squamous cell carcinoma of head and neck (SSCHN): Retrospective study of a single institution. J Clin Oncol; 2009 May 20;27(15_suppl):e17047

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Localizations of primitive tumor: oral cavity (14%), oropharynx (30%), hypopharynx (39%) larynx (7%), rhinopharynx (4%), or other (6%).

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  • (PMID = 27961770.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Haritha C, Shankar V: Oral morphine gargles: A cost effective approach for pain relief in patients with chemoradiation induced acute oral mucositis in head and neck cancers. J Clin Oncol; 2009 May 20;27(15_suppl):e20504

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2007, with adv. head and neck cancers (54 oropharynx, 42 hypopharynx & 10 nasopharynx) were included in the study.

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  • (PMID = 27960947.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Mercke C, Wickart-Johansson G, Sjödin H, Adell G, Nyman J, Haugen H: Upfront chemotherapy and accelerated radiotherapy with EGFR inhibition for locally advanced inoperable head and neck cancer. J Clin Oncol; 2009 May 20;27(15_suppl):6040

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Patients (pts) had previously untreated stage III/IV M0,WHO 0-1, unresectable squamous cell carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx and were scheduled for 2 cycles of TPF (docetaxel 75 mg/m2 and cisplatin 75 mg/m2 day 1 and 5-FU 1,000 mg/m2 96 hours CI) every 3 weeks followed by RT (68 Gy/4.5 weeks) with E given one week before (400 mg/m2) and weekly during RT (250 mg/m2).
  • Neck dissection was planned for pts with N2-3 and complete response (CR) at the primary tumour.
  • Tumour response was evaluated according to RECIST with CT, MRI or PET/CT after CT and at 6 weeks follow up.
  • Median age 57, 60 males, 3 oral cavity, 44 oropharynx, 10 larynx, and 11 hypopharynx.
  • 30 pts were followed beyond 6 weeks and evaluated for response and early toxicity: stage IV disease 24 (T4, n = 6, N3, n = 3), median age 60, 25 males, 18 oropharynx, 5 larynx, and 7 hypopharynx.
  • Vital tumour in resected specimen 0/13.

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  • (PMID = 27961904.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Lefebvre J, Pointreau Y, Rolland F, Alfonsi M, Baudoux A, Sire C, de Raucourt D, Bardet E, Tuchais C, Calais G, Groupe Oncologie Radiotherapie Tete Et Cou (GORTEC): Sequential chemoradiotherapy (SCRT) for larynx preservation (LP): Preliminary results of the randomized phase II TREMPLIN study. J Clin Oncol; 2009 May 20;27(15_suppl):6010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Previously untreated patients (pts) with larynx or hypopharynx squamous cell carcinoma and candidates for a total laryngectomy were eligible for this randomized phase II study.
  • RESULTS: From March 2006 to April 2008 (end of accrual), 153 pts with stage III-IV larynx/hypopharynx cancer were enrolled in the study and could start ICT.

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  • (PMID = 27962406.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Lan CT, Amirkhan RH, Gray T, Xie Y, Dowell JE: ERCC-1 (E) expression and its effect on survival in patients (pts) receiving concurrent cisplatin (C) and radiation (R) for locally advanced head and neck cancer (HNC). J Clin Oncol; 2009 May 20;27(15_suppl):e17033

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Scoring was as follows: 0 = 0% of tumor nuclei were positive, 1+ = less than 50%, 2+ = 50-75% and 3+ = 75-100%.
  • Median age 59 (range 41 - 80); 99% male; 7% stage II, 19% stage III, 73% stage IV; primary site - 4% oral cavity, 56% oropharynx, 14% hypopharynx, 23% larynx, 3% nasopharynx; Tumor grade - 60% moderately differentiated, 4% well differentiated, 15% poorly differentiated, 21% not specified; Performance status 0-25%, 1-45%, 2-8%, unknown-22%; E scoring was 0 in 0%, 1+ (14%), 2+ (42%), 3+ (44%).
  • In multivariate analysis, the only significant predictor was hypopharynx with a HR of 3.18 (95% CI 1.02-9.88; p = 0.046).

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  • (PMID = 27961810.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Specenier PM, Lalami Y, Vermorken J, Lacombe D, El-Hariry I, Bogaerts J, Awada A: EORTC 24051: Unexpected side effects of a phase I study of TPF induction chemotherapy (IC) followed by chemoradiation (CRT) with lapatinib (LAP), a dual EGFR/ErbB2 inhibitor, in patients with locally advanced larynx and hypopharynx squamous cell carcinoma (LA-LxHxSCC). J Clin Oncol; 2009 May 20;27(15_suppl):6017

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] EORTC 24051: Unexpected side effects of a phase I study of TPF induction chemotherapy (IC) followed by chemoradiation (CRT) with lapatinib (LAP), a dual EGFR/ErbB2 inhibitor, in patients with locally advanced larynx and hypopharynx squamous cell carcinoma (LA-LxHxSCC).
  • : 6017 Background: CRT is considered a standard approach for LA-LxHxSCC.
  • METHODS: Eligible tumors were SCCHN: T3-T4 larynx (Lx), T2-T4 hypopharynx (Hx) N0-3 M0.
  • RESULTS: Seven male patients were included; tumor sites: LX (n = 3) / Hx: (n = 4), median age 59 years (range: 47-79), WHO PS 0-1, no severe or uncontrolled comorbidity.
  • CONCLUSIONS: These data suggest that LAP should not be combined with TPF IC regimen for LA-LxHxSCC due to prohibited toxicity.

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  • (PMID = 27962424.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Savaraj N, Dinh V, Chua L, Bustillo P, Nissim K: Role of concurrent chemoradiotherapy in organ preservation for locally advanced head and neck cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e17044

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is unclear, though, whether this could be accomplished in other tumor sites without sacrificing locoregional control and/or survival.
  • Out of these patients, 52% had stage III disease and 50% had primary sites in the oropharynx; the remaining included larynx and hypopharynx.
  • Overall survival was best for laryngeal and oropharyngeal cancer (63 and 46 months, respectively) compared to hypopharyngeal cancer (22 months).
  • Although organ preservation is possible for the majority of patients with locally advanced head and neck cancer, however, the poor survival seen in hypopharyngeal cancer needs further investigation.

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  • (PMID = 27961781.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Herchenhorn D, Souza AL, Souza AM, Boasquevisque ET, Boasquevisque EM, Dias FL, Small I, Knust R: Prognostic impact of radiology response and tumor volume among patients with locally advanced squamous cell carcinoma of the head and neck (LASCHNC) treated with concomitant chemoradiation. J Clin Oncol; 2009 May 20;27(15_suppl):e17035

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic impact of radiology response and tumor volume among patients with locally advanced squamous cell carcinoma of the head and neck (LASCHNC) treated with concomitant chemoradiation.
  • Tumor volume as well as post-treatment CT radiology response have been studied in small retrospective series.
  • An analysis of tumor volume and CT radiology response-score to endoscopic and pathologic responses as well as disease free survival was performed.
  • METHODS: In a single institution phase I-II study LASCHNC of oropharynx, hypopharynx and larynx were treated with concurrent radiation, cisplatin and erlotinib.
  • Tumor volume was measured by multiplying the longest diameter by 0,523. (Cancer Res Clin Oncol.
  • 2005), CT post-treatment changes score used as proposed by Pamejier et al., using a 3-point CT-score: 1 = expected post-treatment changes; 2 = focal mass with a maximal diameter of < 1 cm and/or asymmetric obliteration of laryngeal tissue planes; 3 = focal mass with a diameter of > 1 cm, or < 50% estimated tumor volume reduction.
  • RESULTS: Median tumor volume (mTV) was 21cm3 (0.3 to 178), median disease free survival (mDFS) in pts with tumor volume greater than mTV was 20.4 months and not reached in patients with tumor volume lower than mTV, log-rank 5.9, p = 0.015.
  • The median tumor volume reduction by CT was 84% (-62 a 100%), 8pts were classified as score 1 (23.5%), 1pt score 2 (2.9%), 25pts score 3 (73%).
  • CONCLUSIONS: There is a great variability in TV in LASCHNC, small tumor volumes were related to longer DFS and there is no correlation between tumor reduction and post-treatment CT score.

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  • (PMID = 27961799.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Hasegawa Y, Hanai N, Terada A, Ozawa T, Goto M: Orotate phosphoribosyl transferase and XPA expressions as predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers. J Clin Oncol; 2009 May 20;27(15_suppl):6084

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orotate phosphoribosyl transferase and XPA expressions as predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers.
  • METHODS: Sixty-four tumor specimens from patients undergoing radical treatment for squamous cell carcinomas of the oro- and hypopharynx in stage II, III, or IV, were included in the present study.
  • There were 30 primary tumors sites in the oropharynx and 34 in the hypopharynx, respectively.

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  • (PMID = 27961950.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Grau JJ, Caballero M, Verger E, Blanch JL: Actual proportion of patients (pts) receiving chemotherapy or cetuximab for head and neck squamous carcinoma (HNSC). J Clin Oncol; 2009 May 20;27(15_suppl):e17058

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary tumor was located in glottis (41%), supraglottis (19%), hypopharynx (11%), oropharynx (20%), or mouth (9%).

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  • (PMID = 27961819.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Galper SL, Deshpande H, Rose MG, Decker RH: Cetuximab versus cisplatin concurrent with IMRT in locally advanced head and neck cancer (LAHNC). J Clin Oncol; 2009 May 20;27(15_suppl):e17030

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patient charts and Tumor Registry data were reviewed for acute and late toxicity and for local/regional failure (LRF), distant metastases and death.
  • RESULTS: The ExRT cohort was significantly older (median age 71 vs 58, p=0.005) and had more larynx/hypopharynx primaries (44% vs 27%).

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  • (PMID = 27961805.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Buentzel J, Micke O, Glatzel M, Bruns F, Kisters K, Muecke R: Evaluation of the effect of selenium on radiation-induced toxicities in head neck cancer patients. J Clin Oncol; 2009 May 20;27(15_suppl):e20698

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumour localizations: oral cancer 15 patients, oropharynx 19 patients, hypopharynx 5 patients, CUP 1 patient.
  • Both groups were well balanced according age, gender, localization and stage of the tumour.

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  • (PMID = 27961744.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Richmon JD, Brumund KT: Reconstruction of the hypopharynx: current trends. Curr Opin Otolaryngol Head Neck Surg; 2007 Aug;15(4):208-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of the hypopharynx: current trends.
  • PURPOSE OF REVIEW: Reconstruction of the hypopharynx continues to present a clinical challenge for the reconstructive surgeon.
  • Increased availability of surgeons trained in microvascular reconstruction and the continued high published success rates have made free flaps an attractive option for hypopharyngeal reconstruction.
  • SUMMARY: With continued publication of overall high success rates coupled with superior functional outcome and increased availability of surgeons trained in microvascular reconstruction, fasciocutaneous free flap reconstruction of the hypopharynx will probably surpass intestinal flaps in reliability and popularity.
  • [MeSH-major] Hypopharynx / surgery. Reconstructive Surgical Procedures / methods

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  • (PMID = 17620892.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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35. Luers JC, Preuss SF, Bovenschulte H, Mackenrodt KA, Beutner D: [Perforation of the hypopharynx after endotracheal intubation]. Anaesthesist; 2008 May;57(5):483-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Perforation of the hypopharynx after endotracheal intubation].
  • A case of perforating injury to the hypopharynx following uneventful intubation is reported.
  • [MeSH-major] Hypopharynx / injuries. Intraoperative Complications / etiology. Intubation, Intratracheal / adverse effects

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  • [Cites] Anesthesiology. 1999 Dec;91(6):1703-11 [10598613.001]
  • [Cites] Laryngoscope. 1982 May;92(5):583-5 [7078336.001]
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  • (PMID = 18373072.001).
  • [ISSN] 0003-2417
  • [Journal-full-title] Der Anaesthesist
  • [ISO-abbreviation] Anaesthesist
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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36. Ruan Y, Chen W, Cui P, Gao P: [The treatment for hypopharynx stenosis using platysma pedicle flap]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Aug;20(15):694-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The treatment for hypopharynx stenosis using platysma pedicle flap].
  • OBJECTIVE: To evaluate the possibility and reliability of platysma pedicle flap transfer in the correction of hypopharynx stenosis,and delineate the operation skills and clinical results.
  • METHOD: Ten patients with hypopharynx stenosis underwent hypopharynx reconstruction using platysma pedicle flap.
  • The results indicate that the platysma pedicle flap is an ideal transplant for hypopharynx reconstruction.
  • [MeSH-major] Constriction, Pathologic / surgery. Hypopharynx / surgery. Reconstructive Surgical Procedures / methods

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  • (PMID = 17037017.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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37. Becker M, Burkhardt K, Dulguerov P, Allal A: Imaging of the larynx and hypopharynx. Eur J Radiol; 2008 Jun;66(3):460-79
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of the larynx and hypopharynx.
  • The purpose of this article is to review currently used imaging protocols for the evaluation of pathologic conditions of the larynx and hypopharynx, to describe key anatomic structures in the larynx and hypopharynx that are relevant to tumor spread and to discuss the clinical role of Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and PET CT in the pretherapeutic workup and posttherapeutic follow-up of patients with squamous cell carcinoma of this region.
  • A detailed discussion of the characteristic neoplastic submucosal invasion patterns, including extension to the preepiglottic space, paraglottic space and laryngeal cartilages and the implications of imaging for tumor staging and treatment planning is provided.
  • As the majority of non-neoplastic conditions do not require imaging the role of CT and MRI is discussed in some particular situations, such as to delineate cysts and laryngoceles, abscess formation in inflammatory conditions, to evaluate laryngeal and hypopharyngeal involvement in granulomatous and autoimmune diseases, and to evaluate the extent of laryngeal fractures due to severe blunt trauma.
  • [MeSH-major] Diagnostic Imaging. Laryngeal Diseases / diagnosis. Pharyngeal Diseases / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / diagnosis. Hypopharynx / anatomy & histology. Hypopharynx / injuries. Hypopharynx / pathology. Larynx / anatomy & histology. Larynx / injuries. Larynx / pathology. Lymphatic Metastasis / diagnosis. Magnetic Resonance Imaging / methods. Neoplasm Invasiveness / diagnosis. Neoplasm Metastasis / diagnosis. Neoplasm Staging. Tomography, Emission-Computed / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 18495402.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 43
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38. Satou Y, Omori T, Tagawa M: [Treatment of superficial carcinoma in the hypopharynx]. Nihon Jibiinkoka Gakkai Kaiho; 2006 Jul;109(7):581-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of superficial carcinoma in the hypopharynx].
  • With technical advances in endoscopy, it has become to possible to find superficial carcinoma even in the hypopharynx.
  • We treated 67 superficial carcinomas (49 cases) of the hypopharynx with local mucosal resection in our hospital, mainly with EMR.
  • With ELPS, it was very easy to recognize lugol-voiding lesions in the hypopharynx, and ELPS enabled us to do en bloc resection even for large lesions that could not be treated with EMR or with microscopic surgery.
  • Diagnosis and treatment of superficial carcinoma of the hypopharynx may thus improve patient prognosis and QOL.

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  • (PMID = 16910578.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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39. Firat Y, Kizilay A, Sogutlu G, Mizrak B: Primary mucosa-associated lymphoid tissue lymphoma of hypopharynx. J Craniofac Surg; 2007 Sep;18(5):1189-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mucosa-associated lymphoid tissue lymphoma of hypopharynx.
  • Mucosa-associated lymphoid tissue lymphomas are low-grade B-cell lymphomas that arise from a number of extranodal sites, including both nonmucosal and mucosal organs such as the hypopharynx.
  • We reported a patient with a primary hypopharynx mucosa-associated lymphoid tissue lymphoma presenting with a swallowing dysfunction and severe throat pain.
  • The last biopsies of the hypopharynx revealed no evidence of lymphoid infiltrate.
  • Mucosa-associated lymphoid tissue lymphoma involving the hypopharynx is rare and there is no consensus on its treatment.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology

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  • (PMID = 17912113.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Rice MJ, Mancuso AA, Gibbs C, Morey TE, Gravenstein N, Deitte LA: Cricoid pressure results in compression of the postcricoid hypopharynx: the esophageal position is irrelevant. Anesth Analg; 2009 Nov;109(5):1546-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cricoid pressure results in compression of the postcricoid hypopharynx: the esophageal position is irrelevant.
  • Measurements were made of the postcricoid hypopharynx, airway compression, and lateral displacement of the cricoid ring during the application of CP.
  • RESULTS: The hypopharynx, not the esophagus, is what lies behind the cricoid ring and is compressed by CP.
  • The distal hypopharynx, the portion of the alimentary canal at the cricoid level, was fixed with respect to the cricoid ring and not mobile.
  • With CP, the mean anterioposterior diameter of the hypopharynx was reduced by 35% and the lumen likely obliterated, and this compression was maintained even when the cricoid ring was lateral to the vertebral body.
  • The hypopharynx and cricoid ring move together as an anatomic unit.
  • [MeSH-major] Cricoid Cartilage / anatomy & histology. Esophagus / anatomy & histology. Hypopharynx / anatomy & histology


41. Tsunoda A, Ishihara A, Kishimoto S, Tsunoda R, Tsunoda K: Head torsion technique for detailed observation of larynx and hypopharynx. J Laryngol Otol; 2007 May;121(5):489-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Head torsion technique for detailed observation of larynx and hypopharynx.
  • We introduce here an easy but effective method for detailed observation of the larynx and hypopharynx.
  • In addition, observation of the opposite side of the hypopharynx also becomes easier.
  • This is a simple but very effective technique for laryngeal and hypopharyngeal observation.
  • [MeSH-major] Endoscopy / methods. Hypopharynx / anatomy & histology. Larynx / anatomy & histology

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  • (PMID = 17164027.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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42. Foote RL: Radiotherapy alone for early-stage squamous cell carcinoma of the larynx and hypopharynx. Int J Radiat Oncol Biol Phys; 2007;69(2 Suppl):S31-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiotherapy alone for early-stage squamous cell carcinoma of the larynx and hypopharynx.
  • PURPOSE: To describe and illustrate examples of early-stage larynx and hypopharynx cancer that can be successfully treated with radiotherapy alone.
  • RESULTS: Early-stage larynx and hypopharynx cancer is defined by tumor extent based on physical and imaging examination.
  • CONCLUSIONS: Radiotherapy alone is appropriate treatment for properly selected early-stage squamous cell carcinoma of the larynx and hypopharynx.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / radiotherapy
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local / diagnosis. Neoplasm Staging. Practice Guidelines as Topic. Radiation Oncology. Radiotherapy Dosage. Societies, Medical

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  • (PMID = 17848288.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Weide D, Thayer MK, Newton AF, Betz O: Comparative morphology of the head of selected sporophagous and non-sporophagous aleocharinae (Coleoptera: Staphylinidae): musculature and hypopharynx-prementum complex. J Morphol; 2010 Aug;271(8):910-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative morphology of the head of selected sporophagous and non-sporophagous aleocharinae (Coleoptera: Staphylinidae): musculature and hypopharynx-prementum complex.
  • 28-30) have shifted posteriorly to the gula, which might enhance the movement posterad of the hypopharynx and partly compensate for the loss of M. 48.
  • We also analyzed the general organization of the hypopharynx-prementum complex and the fine structure of the mandibles through SEM studies.
  • In these species, the hypopharynx is elevated and displaced anteriorly, bearing a bowl-like depression on its surface that functions as a mortar where spores are ground between the hypopharynx and the mandibles.
  • [MeSH-minor] Animals. Feeding Behavior. Head / anatomy & histology. Hypopharynx / anatomy & histology. Mandible / anatomy & histology. Muscles / anatomy & histology. Phylogeny. Pollen. Spores, Fungal. Tomography, X-Ray

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  • [Copyright] J. Morphol. 271:910-931, 2010. (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20535815.001).
  • [ISSN] 1097-4687
  • [Journal-full-title] Journal of morphology
  • [ISO-abbreviation] J. Morphol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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44. Ndiaye IC, Diom ES, Diop F, Tall A, Ndiaye M, Essalki I, Déguénonvo R, Diallo BK, Diouf R, Diop EM: Squamous carcinoma of the hypopharynx in children in Sénégal: between disarray and enigma. Int J Pediatr Otorhinolaryngol; 2009 Mar;73(3):357-61
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  • [Title] Squamous carcinoma of the hypopharynx in children in Sénégal: between disarray and enigma.
  • INTRODUCTION: The squamous carcinoma of the hypopharynx constitutes the first reason of hospitalization in our department.
  • OBJECTIVES: To specify the place of the children in hypopharynx cancers.
  • In 5 cases the lesion was spreading to the totality of the hypopharynx.
  • DISCUSSION: Our set is the richest set through the world of hypopharyngeal cancers in children.
  • CONCLUSION: The cancer of the hypopharynx essentially affects the young women in Sénégal without alcohol or tobacco consumption.
  • [MeSH-major] Carcinoma, Squamous Cell. Hypopharyngeal Neoplasms

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  • (PMID = 19135726.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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45. Güvenç MG, Dereköylü L, Korkut N, Oz F, Oz B: Intravascular papillary endothelial hyperplasia (Masson lesion) of the hypopharynx and larynx. Ear Nose Throat J; 2008 Dec;87(12):700-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravascular papillary endothelial hyperplasia (Masson lesion) of the hypopharynx and larynx.
  • Masson lesion is characterized by a benign intravascular papillary hyperplasia and subsequent thrombosis.
  • In this article, we report a case of intravascular papillary endothelial hyperplasia of the hypopharynx and larynx, which caused dysphagia in an 18-year-old female patient.
  • We discuss the clinical and histopathologic features, differential diagnosis, and treatment of this uncommon entity.
  • [MeSH-major] Endothelium, Vascular / pathology. Hemangiosarcoma / pathology. Hyperplasia / pathology. Hypopharyngeal Neoplasms / pathology. Laryngeal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Diagnosis, Differential. Endoscopy / methods. Female. Humans. Severity of Illness Index

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  • (PMID = 19105147.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Cimino-Mathews A, Broman JH, Westra WH, Illei PB: Iron pill-induced tumefactive mucosal injury of the hypopharynx. Am J Surg Pathol; 2010 Nov;34(11):1720-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Iron pill-induced tumefactive mucosal injury of the hypopharynx.
  • Iron pill-induced mucosal injury of the airways with massive necrosis and stricture of the lower airways is known to occur, but symptomatic injury of the hypopharyngeal mucosa secondary to therapeutic oral iron ingestion has not been described.
  • We report iron-sulfate-induced mucosal injury of the hypopharynx in a patient receiving therapeutic oral iron supplementation.
  • Imaging studies and clinical examination revealed an ulcerated and protuberant hypopharyngeal mass.
  • [MeSH-major] Ferrous Compounds / adverse effects. Hematinics / adverse effects. Hypopharynx / drug effects. Ulcer / chemically induced

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  • (PMID = 20975344.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ferrous Compounds; 0 / Hematinics; 0 / Tablets; 39R4TAN1VT / ferrous sulfate
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47. Ferlito A, Rinaldo A: Paraneoplastic syndromes in patients with cancer of the larynx and hypopharynx. Ann Otol Rhinol Laryngol; 2007 Jul;116(7):502-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraneoplastic syndromes in patients with cancer of the larynx and hypopharynx.
  • These associations of symptoms and signs are not directly related to the site or local manifestations of a malignant tumor or its metastases, but their recognition may facilitate the detection of malignancies or recurrences.
  • Different oncotypes have rarely been associated with paraneoplastic syndromes in patients with cancer of the larynx and hypopharynx.
  • [MeSH-major] Hypopharyngeal Neoplasms / epidemiology. Laryngeal Neoplasms / epidemiology. Paraneoplastic Syndromes / classification. Paraneoplastic Syndromes / epidemiology. Skin Neoplasms / epidemiology
  • [MeSH-minor] Diagnosis, Differential. Humans. Prevalence. Skin Diseases / diagnosis. Skin Diseases / epidemiology

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  • (PMID = 17727081.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 123
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48. Benazzo M, Bertino G, Spasiano R, Gatti P, Capelli M: [Decisional algorithm in extended neoplasms of the hypopharynx and the cervical esophagus]. Suppl Tumori; 2005 May-Jun;4(3):S190-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Decisional algorithm in extended neoplasms of the hypopharynx and the cervical esophagus].
  • [Transliterated title] L'algoritmo decisionale nelle neoplasie estese dell'ipofaringe ed esofago cervicale.
  • Hypopharynx reconstruction must deal with restoration of not a simple tubed conduit but a complex arrangement of constrictive and propulsive forces with fine sensory circuits.
  • The chosen surgical approach should guarantee both complete removal of tumor and re-establishement of the two primary functions of the district: first swallowing and then phonation.
  • We retrospectively reviewed data of 67 patients who had undergone oncologic reconstruction of hypopharynx with either pedicled or free flaps at the ENT Department of IRCCS Policlinico S Matteo, University of Pavia, between November 1994 and July 2004.
  • In conclusion, the data collected suggest that free flaps rapresent the first choice for both partial and total oncologic hypopharyngeal reconstruction, while pedicled flaps should be taken into account when free ones contraindicated by general or vascular conditions.
  • [MeSH-major] Algorithms. Esophageal Neoplasms / surgery. Hypopharyngeal Neoplasms / surgery. Reconstructive Surgical Procedures / methods

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  • (PMID = 16437981.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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49. Disa JJ, Pusic AL, Mehrara BJ: Reconstruction of the hypopharynx with the free jejunum transfer. J Surg Oncol; 2006 Nov 1;94(6):466-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of the hypopharynx with the free jejunum transfer.
  • This review will examine indications, operative technique, postoperative management, and expected outcomes for the hypopharyngeal reconstruction with the free jejunum flap.
  • The free jejunal transfer can be rapidly harvested in most instances and transplanted to the hypopharyngeal region with a greater than 95% success rate.
  • The jejunum fee flap is most useful for circumferential defects of the hypopharynx, but can also be used for partial defects.
  • [MeSH-major] Hypopharynx / surgery. Jejunum / transplantation. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 17061270.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 72
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50. Sesterhenn AM, Muller HH, Wiegand S, Teymoortash A, Folz BJ, Werner JA: Cancer of the oro- and hypopharynx - when to expect recurrences? Acta Otolaryngol; 2008 Aug;128(8):925-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer of the oro- and hypopharynx - when to expect recurrences?
  • CONCLUSION: Relapse-free survival (RFS) of patients suffering from cancers located in the oro- and hypopharynx (COH) is strongly related to the localization and initial tumor stage; 25% of relapses remain undetected by the patients themselves.
  • Most of these relapses are already incurable at the time of diagnosis.
  • The aim of the present study was the assessment of time intervals between initial diagnosis of the primary tumor and its relapse.
  • RESULTS: RFS was strongly related to the location of the primary tumor.
  • The median RFS of patients suffering from oropharyngeal cancer was longer (86 months) than that of patients with hypopharyngeal carcinomas (45 months).
  • Patients with COH revealed an accumulation of recurrent disease within the first 33 months after initial diagnosis.
  • [MeSH-major] Hypopharyngeal Neoplasms / therapy. Neoplasm Recurrence, Local / diagnosis. Oropharyngeal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 18612853.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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51. Liu B, Pan Z, Ji W: [Remaining laryngeal flap reconstruction of the hypopharynx in pyriform sinus carcinoma resection]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Mar;20(6):241-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Remaining laryngeal flap reconstruction of the hypopharynx in pyriform sinus carcinoma resection].
  • OBJECTIVE: To discuss the feasibility of using remaining laryngeal flap to reconstruct the hypopharyngeal defect in pyriform sinus carcinoma resection.
  • METHOD: Seven patients with pyriform sinus carcinoma to reconstruct hypopharyngeal defect with remaining laryngeal flap were summarized.
  • Half the hypopharynx and half the larynx were resected and unaffected half the larynx was reserved.
  • The food canal was reconstructed with the pulled-down mucosa of the base of the tongue, the unaffected half of the larynx and the remnant hypopharyngeal mucosa.
  • No hypopharyngeal stenosis was observed.
  • CONCLUSION: To the selected cases with pyriform sinus carcinoma, reconstruction of hypopharyngeal defect with laryngeal flap is simple and safe.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery. Hypopharynx / surgery. Larynx / surgery

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  • (PMID = 16739372.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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52. Xiao Q, Hu GH, Zhong SX, Qian Y, Zeng Q, Hong SL: Reconstruction of hypopharynx and cervical oesophagus for treatment of advanced hypopharyngeal carcinoma and recurrent laryngeal carcinoma. Asian J Surg; 2010 Jan;33(1):14-9
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of hypopharynx and cervical oesophagus for treatment of advanced hypopharyngeal carcinoma and recurrent laryngeal carcinoma.
  • OBJECTIVE: To review our treatment strategy and outcomes in reconstructing the hypopharynx and cervical oesophagus with five techniques for advanced hypopharyngeal carcinoma and recurrent laryngeal carcinoma.
  • Defects of the hypopharynx and cervical oesophagus were reconstructed using the remaining laryngeal mucosa flap, pectoralis major myocutaneous flap, forearm free flap, jejunal free flap or latissimus dorsi myocutaneous flap.

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  • [Copyright] Copyright (c) 2010 Asian Surgical Association. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20497877.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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53. Wan GL, Sun JW, Fang R, Hu YM, Wang YF: [Transoral endoscopic CO2 laser surgery for hypopharynx in experimental animals]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 May;43(5):369-73
MedlinePlus Health Information. consumer health - Endoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Transoral endoscopic CO2 laser surgery for hypopharynx in experimental animals].
  • OBJECTIVE: To explore the substantial resection limits of CO2 laser surgery for hypopharynx and the course of wound healing in animals, for the purpose of evaluating the clinic usefulness of transoral CO2 laser surgery in the treatment of selected hypopharyngeal carcinomas.
  • Group one (11 dogs) received left piriform sinus resection, group two (12 dogs) received the resection of posterior wall of the hypopharynx.
  • The whole larynx and hypopharynx were taken out and the specimens were examined by naked eyes and under microscope.
  • In group two (resection of the posterior wall of the hypopharynx), the wound surface was (7.0 +/- 0.5) cm2 and the healing time was (39.8 +/- 1.9) d.
  • CONCLUSIONS: Transoral CO2 laser was suitable for partial hypopharynx resection.
  • [MeSH-major] Endoscopy. Hypopharynx / surgery. Laser Therapy. Pharyngectomy / methods

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  • (PMID = 18717315.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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54. Martin A, Jäckel MC, Christiansen H, Mahmoodzada M, Kron M, Steiner W: Organ preserving transoral laser microsurgery for cancer of the hypopharynx. Laryngoscope; 2008 Mar;118(3):398-402

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Organ preserving transoral laser microsurgery for cancer of the hypopharynx.
  • OBJECTIVE: To assess the feasibility of transoral laser microsurgery (TLM) in the treatment of hypopharyngeal cancer, with a special focus on piriform sinus carcinomas, and to report the oncologic and functional outcomes.
  • METHODS: A total of 172 patients with previously untreated squamous cell carcinoma of the hypopharynx were eligible for this study (1986-2003).
  • The whole group of 172 hypopharyngeal cancer patients was analyzed, with an additional special focus on the homogenous group of piriform sinus carcinomas (n = 150).
  • [MeSH-major] Carcinoma / surgery. Hypopharyngeal Neoplasms / surgery. Laser Therapy. Microsurgery / methods

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  • (PMID = 18091337.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Takahashi T, Higo R, Nakata H, Sugasawa M: Leiomyosarcoma of the hypopharynx: a case report. Auris Nasus Larynx; 2008 Jun;35(2):304-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyosarcoma of the hypopharynx: a case report.
  • Cases of leiomyosarcoma in the head and neck are very rare with only four reports of a leiomyosarcoma originating in the hypopharynx.
  • A rare case of leiomyosarcoma of the hypopharynx is described.
  • A smooth-surfaced tumor was found extending from the postcricoid to an area in the left pyriform sinus, and the vocal cord on the left side was fixed.
  • Imaging studies, including FDG-PET CT imaging showed the tumor in the postcricoid, but no distinguishable distant metastases.
  • In immunohistochemical staining, the tumor was positive for desmin and muscle actin, while it was negative for myoglobin, myogenin, cytokeratin, and S-100 protein.
  • Those features lead to the diagnosis of a leiomyosarcoma.
  • Immunohistochemical staining and electron microscopic examination are essential for a definite diagnosis of leiomyosarcoma.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Leiomyosarcoma / pathology

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  • (PMID = 18258399.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin
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56. Lapeyre M, Bailly C, Toledano I, Montalban A, Russier M: [Hypopharynx and larynx cancers: propositions for the selection and the delineation of peritumoral microscopic disease volumes (lymph nodes excluded)]. Cancer Radiother; 2010 Nov;14 Suppl 1:S43-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hypopharynx and larynx cancers: propositions for the selection and the delineation of peritumoral microscopic disease volumes (lymph nodes excluded)].
  • [Transliterated title] Cancer de l'hypopharynx et du larynx : proposition de sélection et délimitation des volumes cibles microscopiques péri-tumoraux (aires ganglionnaires exclues).
  • This article reviews the concept of selectivity in peritumoral microscopic disease to be included in the Clinical Target Volume (CTV) for elective treatment for larynx and hypopharynx squamous cell carcinoma (50 Gy or 54-60 Gy for SIB-IMRT), using the local tumoral spread.
  • [MeSH-major] Hypopharyngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / radiotherapy
  • [MeSH-minor] Humans. Hypopharynx / anatomy & histology. Hypopharynx / radiation effects. Larynx / anatomy & histology. Larynx / radiation effects. Lymph Nodes / pathology. Lymph Nodes / radiography. Neoplasm Metastasis. Radiotherapy, Conformal / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21129669.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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57. Biszewska J, Rzewnicki I, Rózańska-Kudelska M, Wierzba U, Jackiewicz M: [Progression of larynx and hypopharynx cancer in the last ten years]. Pol Merkur Lekarski; 2005 Sep;19(111):351-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Progression of larynx and hypopharynx cancer in the last ten years].
  • Epidemiological analysis of patients with the larynx and hypopharynx cancer, who were treated in the Department of Otolaryngology in Bialystok from 1999 to 2004 was performed.
  • (1) number of patients, (2) sex, (3) profession and place of living, (4) primary site of the tumour, (5) clinical advancement stage of the disease.
  • The most common site of the primary tumour was the supraglottic region (56.9%).
  • The analysis showed that the numbers of patients with T3/T4 clinical advancement stage of the tumour was larger (64.9%).
  • [MeSH-major] Hypopharyngeal Neoplasms / epidemiology. Laryngeal Neoplasms / epidemiology
  • [MeSH-minor] Employment. Female. Humans. Male. Neoplasm Staging. Poland / epidemiology. Sex Distribution

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  • (PMID = 16358867.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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58. Nagano H, Yoshifuku K, Kurono Y: A useful procedure for observing the cervical esophagus via the hypopharynx. Auris Nasus Larynx; 2010 Dec;37(6):713-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A useful procedure for observing the cervical esophagus via the hypopharynx.
  • OBJECTIVE: The aim of the study was to evaluate upper gastrointestinal endoscopy with movable over tube (i.e., the movable over tube method) for observing the hypopharynx to cervical esophagus, for use in treatment, and to determine its safety.
  • The patients consisted of nine cases of globus sensation, eight cases of hypopharyngeal cancer (post-chemoradiotherapy), three cases of hypopharyngeal cancer (untreated), two cases of hoarseness, two cases of unknown primary carcinoma, two cases of foreign body, one case of esophageal cancer, and one case of dysphagia.
  • We used upper gastrointestinal endoscopy with movable over tube to examine the hypopharynx to the cervical esophagus in subjects.
  • RESULTS: With the movable over tube method, which was performed under pharyngeal surface anesthesia and an infusion of diazepam (5-10mg/kg body weight), one could observe from the hypopharynx to cervical esophagus without any blind spots.
  • CONCLUSIONS: The results suggest that the movable over tube method is an easy, useful, and safe method to observe the region from the hypopharynx to the cervical esophagus.
  • [MeSH-major] Endoscopy, Gastrointestinal / instrumentation. Endoscopy, Gastrointestinal / methods. Esophageal Diseases / pathology. Esophagoplasty / methods. Hypopharynx / pathology. Pharyngeal Diseases / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Deglutition Disorders / pathology. Equipment Design. Esophageal Neoplasms / pathology. Esophagitis / pathology. Female. Foreign Bodies / pathology. Foreign Bodies / radiography. Foreign Bodies / surgery. Humans. Hypopharyngeal Neoplasms / pathology. Male. Middle Aged. Neck. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2010. Published by Elsevier Ireland Ltd.
  • (PMID = 20434284.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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59. Suhara T, Moriyama K, Hosokawa Y, Ai K, Takeda J: [Airway management in a patient with cavernous hemangioma of the hypopharynx and larynx]. Masui; 2010 May;59(5):618-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Airway management in a patient with cavernous hemangioma of the hypopharynx and larynx].
  • A 48-year-old woman was diagnosed with cavernous hemangioma of hypopharynx and larynx, which extended to the trachea and mediastinum.
  • She was scheduled for tracheostomy and open surgical excision of hypopharynx hemangioma under general anesthesia.
  • Although tracheal intubation was successfully accomplished without injuring the hypopharynx hemangioma, tracheostomy was difficult because of bleeding from the surgical site.
  • Her airway was managed with endotracheal tube for 7 days, and open surgical excision of hypopharynx hemangioma was performed on day 7.
  • [MeSH-major] Anesthesia, General. Hemangioma, Cavernous / surgery. Hypopharyngeal Neoplasms / surgery. Intubation, Intratracheal / methods. Laryngeal Neoplasms / surgery. Neoplasms, Multiple Primary

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  • (PMID = 20486575.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; 0 / Piperidines; P10582JYYK / remifentanil
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60. Sowa J, Konarska A: [Larynx and hypopharynx cancer morbidity in West Pomerania region in the years 1990-2000]. Otolaryngol Pol; 2007;61(4):433-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Larynx and hypopharynx cancer morbidity in West Pomerania region in the years 1990-2000].
  • 1413 patient (1236 males and 177 females) with cancer of larynx or hypopharynx were treated in the ENT Department of the Pomeranian Medical Academy in Szczecin from 1990 to 2000.
  • In the paper, based on the review of the cases history the following aspects have been determinated: incidence rate of the laryngeal cancer in the West Pomerania region, cigarette smoking, size and primary site of the tumor, nodular metastases and clinical stage of the disease.
  • The most common primary site of the tumor was supraglottis--788 cases (56.6%), next glottis--433 cases (29.9%), hypopharynx 172 cases (12.2%), subglottis--10 case (0.7%), and also 10 cases (0.7%) unindentified.
  • With regard the local manifestation of tumor (T) the most numerous group was T4--580 case (41%) and then T3--452 cases (32%).
  • There was also a statistically significant increase of the number of patients with hypopharyngeal cancer and at stage IV of the disease.
  • [MeSH-major] Hypopharyngeal Neoplasms / epidemiology. Laryngeal Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology

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  • (PMID = 18260227.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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61. Joo YH, Sun DI, Cho KJ, Cho JH, Kim MS: The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):945-50
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx.
  • The aim of this study was to analyze the prevalence and prognostic importance of paratracheal lymph nodes in squamous cell carcinoma of the hypopharynx.
  • A retrospective review of 64 previously untreated patients with squamous cell carcinoma (SCC) of the hypopharynx that underwent surgery was performed.
  • There was a significant correlation between paratracheal lymph node metastasis and cervical metastasis (p = 0.005), and the primary tumor site (postcricoid, 57.1%; pyriform sinus, 20.0%; posterior pharyngeal wall, 8.3%) (p = 0.039).
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hypopharyngeal Neoplasms / pathology. Lymphatic Metastasis / pathology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Laryngectomy. Lymph Node Excision. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasm Staging. Pharyngectomy. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies

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  • [Cites] Head Neck. 2000 Jul;22(4):380-5 [10862022.001]
  • [Cites] Laryngoscope. 2006 Jul;116(7):1268-72 [16826073.001]
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  • (PMID = 19949954.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2857797
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62. Motoyama S, Saito R, Maruyama K, Okuyama M, Sasaki K, Wako M, Kitamura A, Ogawa J: Sound spectrogram analysis in patients receiving Kawahara's surgical voice restoration for advanced carcinoma of the hypopharynx and cervical esophagus. Dis Esophagus; 2007;20(1):42-6
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sound spectrogram analysis in patients receiving Kawahara's surgical voice restoration for advanced carcinoma of the hypopharynx and cervical esophagus.
  • Between 2002 and 2005, 10 consecutive patients underwent laryngopharyngoesophagectomy with Kawahara's surgical voice restoration for advanced carcinoma of the hypopharynx and/or cervical esophagus at Akita University Hospital, Japan.

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  • (PMID = 17227309.001).
  • [ISSN] 1120-8694
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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63. Pathak B, Yu DC, Linden BC: Transoral closure of a perforation of the hypopharynx from blunt trauma. J Pediatr Surg; 2009 Dec;44(12):2402-5
MedlinePlus Health Information. consumer health - Neck Injuries and Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral closure of a perforation of the hypopharynx from blunt trauma.
  • Hypopharyngeal perforation secondary to blunt trauma is a rare injury.
  • Here, we present a case of a 17-year-old adolescent boy who had a hypopharyngeal tear from direct blunt trauma to the anterior neck received during a high school football game.
  • Rigid endoscopy diagnosed a 3-cm linear tear in the posterior hypopharynx.
  • [MeSH-major] Football / injuries. Hypopharynx / injuries. Hypopharynx / surgery. Lacerations / surgery. Neck Injuries / surgery. Wounds, Nonpenetrating / complications

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  • (PMID = 20006037.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Ikeda Y, Tsukuda M, Ishitoya J, Arai Y, Matsuda H, Katori H, Taguchi T, Yoshida T, Ono M, Sakuma Y, Yagisawa M, Saito N: Four cases of simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach. Otolaryngol Head Neck Surg; 2005 May;132(5):788-93
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Four cases of simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach.
  • OBJECTIVE: To study the efficacy of intensive chemotherapy for simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach.
  • METHODS: From April 2000 to March 2002, we treated 4 patients who had simultaneous triple primary cancers, including hypopharyngeal, esophageal, and gastric carcinomas.
  • RESULTS: In 3 of 4 patients, all 3 primary cancers could be controlled by intensive induction chemotherapy and concurrent chemoradiotherapy for hypopharyngeal cancer and by endoscopic mucosal resection or argon plasma coagulation for esophageal and gastric carcinomas.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Esophageal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / drug therapy. Stomach Neoplasms / drug therapy

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  • (PMID = 15886636.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Wiedemann K, Graser A, Lang RA, Rader T, Suckfuell M: [Persistent pharyngeocutaneous fistula after transcervical resection of a diverticulum of the hypopharynx]. HNO; 2009 Dec;57(12):1275-9
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  • [Title] [Persistent pharyngeocutaneous fistula after transcervical resection of a diverticulum of the hypopharynx].
  • CASE: A 26-year-old white male patient had undergone resection of a diverticulum of the hypopharynx and myotomy of the cricopharyngeal muscle elsewhere.
  • [MeSH-major] Cutaneous Fistula / etiology. Fistula / etiology. Hypopharynx / surgery. Pharyngeal Diseases / etiology. Postoperative Complications / etiology. Zenker Diverticulum / surgery

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  • [Cites] Schweiz Med Wochenschr. 2000 Apr 22;130(16):590-6 [10842775.001]
  • [Cites] Laryngorhinootologie. 2003 May;82(5):358-63 [12800082.001]
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  • (PMID = 17882393.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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66. Bień S, Kamiński B, Zyłka S, Mezyk R, Piasta Z: Evolution of the epidemiology and clinical characteristics of larynx and hypopharynx carcinoma in Poland from 1991 to 2001. Eur Arch Otorhinolaryngol; 2008 Jul;265 Suppl 1:S39-46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolution of the epidemiology and clinical characteristics of larynx and hypopharynx carcinoma in Poland from 1991 to 2001.
  • A retrospective analysis was performed of 12,888 cases of larynx and hypopharynx carcinoma diagnosed in 19 ENT Departments in Poland during an 11-year period from 1991 to 2001.
  • An assessment of basic epidemiological data, including also tumor site and disease stage at the time of diagnosis, was conducted.
  • Majority of cases (57.4%) presented with local advanced stage (T3+T4) carcinoma of the larynx and hypopharynx, with the highest rate (81.0%) for the pyriform sinus carcinomas, and with the lowest rate for glottic tumors (41.8%).
  • Distant metastases at the time of diagnosis were registered in 2.2% of the analyzed cases, with the highest percentage in the posterior pharyngeal wall (7.6%) and pyriform sinus (7.4%) carcinomas.
  • [MeSH-major] Hypopharyngeal Neoplasms / epidemiology. Laryngeal Neoplasms / epidemiology

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  • [Cites] Otolaryngol Pol. 2001;55(2):135-7 [11494727.001]
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  • (PMID = 17955255.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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67. Chu PY, Chang SY: Reconstruction of the hypopharynx after surgical treatment of squamous cell carcinoma. J Chin Med Assoc; 2009 Jul;72(7):351-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of the hypopharynx after surgical treatment of squamous cell carcinoma.
  • Squamous cell carcinoma of the hypopharynx (HPSCC) tends to present with an advanced stage.
  • Radical surgery may result in a large surgical defect of the hypopharyngeal and cervical esophageal regions.
  • The ideal method for hypopharyngeal reconstruction should have the following attributes if possible: single-stage procedure, high success rate of tissue transfer, low donor-site morbidity, low fistula and stenosis rates, restoration of the ability to speak and swallow, able to achieve successful reconstruction in a heavily radiated area and tolerance of postoperative radiotherapy.
  • Finally, we will introduce the technique of laryngotracheal flap reconstruction, which was developed in our institution and has proved to be a simple and reliable method for hypopharyngeal reconstruction.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery. Hypopharynx / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 19581140.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 26
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68. Hall SF, Groome PA, Irish J, O'Sullivan B: The natural history of patients with squamous cell carcinoma of the hypopharynx. Laryngoscope; 2008 Aug;118(8):1362-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The natural history of patients with squamous cell carcinoma of the hypopharynx.
  • OBJECTIVES/HYPOTHESIS: To provide the baseline information on the natural history of patients with squamous cell carcinoma of the hypopharynx to help clinicians, researchers, and patients assess the relative effectiveness of treatment options when the best treatment is not known and newer treatments are being proposed.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / epidemiology
  • [MeSH-minor] Aged. Aged, 80 and over. Cardiovascular Diseases / epidemiology. Cause of Death. Comorbidity. Diabetes Mellitus / epidemiology. Disease Progression. Female. Gastrointestinal Diseases / epidemiology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm, Residual / epidemiology. Ontario / epidemiology. Registries. Respiratory Tract Diseases / epidemiology. Retrospective Studies. Socioeconomic Factors

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  • (PMID = 18496152.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Völker HU, Scheich M, Nowack I, Metzger A, Haubitz I, Puppe B, Hagen R, Müller-Hermelink HK, Völter C: Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx--value of conventional evaluation and additional immunohistochemical staining of D2-40. World J Surg Oncol; 2009;7:25
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx--value of conventional evaluation and additional immunohistochemical staining of D2-40.
  • However, the importance of this immunohistochemical staining was not investigated in squamous cell carcinomas (SCC) of larynx and hypopharynx.
  • AIM: This study was performed to compare the diagnostic potential of conventional and immunohistochemical determination of L1 in SCC of larynx and hypopharynx with special respect to the predictive value for nodal metastasizing and prognosis.
  • METHODS: 119 SCCs of the larynx (n = 70) respectively hypopharynx (n = 49) were investigated.
  • L1 was searched microscopically in a standardized magnification (x200) in serial sections of tumor samples (1 section per cm tumor diameter).
  • Only in SCC of hypopharynx, a combination of both methods revealed patients with a significant worse prognosis.
  • CONCLUSION: The status of lymphatic vessel invasion should be documented in standardized tumor reports.
  • [MeSH-major] Antibodies, Monoclonal. Hypopharyngeal Neoplasms / diagnosis. Laryngeal Neoplasms / diagnosis. Lymphangiogenesis / immunology. Lymphatic Diseases / diagnosis

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  • (PMID = 19261178.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / monoclonal antibody D2-40
  • [Other-IDs] NLM/ PMC2653073
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70. Jaquet Y, Pilloud R, Grosjean P, Radu A, Monnier P: Extended endoscopic mucosal resection in the esophagus and hypopharynx: a new rigid device. Eur Arch Otorhinolaryngol; 2007 Jan;264(1):57-62
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extended endoscopic mucosal resection in the esophagus and hypopharynx: a new rigid device.
  • We present a new device allowing for the diagnosis and treatment of extended superficial lesions of the esophagus and hypopharynx such as early squamous cell carcinoma, intestinal metaplasia with high grade intraepithelial neoplasia or early adenocarcinoma arising in Barrett's esophagus.
  • The deep resection margin was precisely located at the submucosal level, a prerequisite for a safe resection of superficial cancers of the esophagus and hypopharynx.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Endoscopy / methods. Esophageal Neoplasms / pathology. Esophageal Neoplasms / surgery. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Minimally Invasive Surgical Procedures / instrumentation
  • [MeSH-minor] Barrett Esophagus / pathology. Barrett Esophagus / surgery. Early Diagnosis. Equipment Design. Humans. Mucous Membrane / pathology

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  • (PMID = 17043858.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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71. Hall SF, Groome PA, Irish J, O'Sullivan B: TNM-based stage groupings in head and neck cancer: application in cancer of the hypopharynx. Head Neck; 2009 Jan;31(1):1-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TNM-based stage groupings in head and neck cancer: application in cancer of the hypopharynx.
  • BACKGROUND: The purpose of this study was to test the Union Internationale Contre le Cancer (UICC)/TNM category-based head and neck cancer stage grouping systems proposed in the literature for their ability to create clinically relevant prognostic groups of like-patients with cancer of the hypopharynx.
  • METHODS: Population-based retrospective survival study of 595 patients with squamous cell carcinoma of the hypopharynx across Ontario, Canada, from January 1990 to January 2000.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Hypopharyngeal Neoplasms / classification
  • [MeSH-minor] Aged. Cause of Death. Female. Head and Neck Neoplasms / classification. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasm Staging / classification. Prognosis

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2009.
  • (PMID = 19031408.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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72. Kruk-Zagajewska A, Paprzycki W, Gawecki W, Borucki Ł, Banaszewski J: [Paratracheal lymph nodes in patients with larynx and hypopharynx cancer in radiological and clinical examination]. Otolaryngol Pol; 2008;62(3):278-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Paratracheal lymph nodes in patients with larynx and hypopharynx cancer in radiological and clinical examination].
  • INTRODUCTION: Paratracheal lymph nodes receive the lymph from the larynx, hypopharynx, esophagus, thyroid gland and trachea.
  • It is evaluated, that metastases to these nodes occur in about 10-30% of patients with cancer of the larynx, hypopharynx or cervical esophagus.
  • MATERIAL AND METHODS: The investigation was performed in 15 patients with advanced larynx and/or hypopharynx cancer.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / secondary. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / surgery

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  • (PMID = 18652149.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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73. Yannopoulos P, Lytras D, Paraskevas KI: Esophageal reconstruction with intraoperative dilatation of the hypopharynx for the management of chronic corrosive esophageal strictures. A technical tip. Eur J Cardiothorac Surg; 2006 Dec;30(6):940-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Esophageal reconstruction with intraoperative dilatation of the hypopharynx for the management of chronic corrosive esophageal strictures. A technical tip.
  • Chronic corrosive strictures of the upper cervical esophagus and hypopharynx resulting from ingestion of caustic substances are a challenging surgical entity when repeated endoscopic dilatations fail to yield satisfactory results.
  • We describe three cases of corrosive upper cervical esophageal strictures treated with intraoperative dilatation of the proximal hypopharyngeal stump and concurrent 'stenting' of the pharyngeal anastomosis with the conduit replacing the esophagus.
  • [MeSH-minor] Adolescent. Adult. Aged. Anastomosis, Surgical / methods. Chronic Disease. Dilatation / methods. Esophagus / surgery. Humans. Hypopharynx / surgery. Intraoperative Care / methods. Male. Stents

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  • (PMID = 17049870.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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74. Anttonen A, Leppä S, Heikkilä P, Grenman R, Joensuu H: Effect of treatment of larynx and hypopharynx carcinomas on serum syndecan-1 concentrations. J Cancer Res Clin Oncol; 2006 Jul;132(7):451-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of treatment of larynx and hypopharynx carcinomas on serum syndecan-1 concentrations.
  • We studied S-syndecan-1 levels longitudinally in a series of patients diagnosed with locoregional squamous cell larynx or hypopharynx carcinoma (n=44) and who we treated with surgery and/or radiation therapy.
  • Syndecan-1 expression was assessed from formalin-fixed and paraffin-embedded tumour samples using immunohistochemistry.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Squamous Cell / therapy. Hypopharyngeal Neoplasms / therapy. Laryngeal Neoplasms / therapy. Membrane Glycoproteins / blood. Proteoglycans / blood

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  • (PMID = 16557382.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / Proteoglycans; 0 / SDC1 protein, human; 0 / Syndecan-1; 0 / Syndecans; 103107-01-3 / Fibroblast Growth Factor 2
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75. Kim JK, Park KK: Foregut duplication cyst of the hypopharynx: a rare cause of upper airway obstruction. J Pediatr Surg; 2007 Jun;42(6):E5-7
MedlinePlus Health Information. consumer health - Throat Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Foregut duplication cyst of the hypopharynx: a rare cause of upper airway obstruction.
  • Foregut duplication cysts of the hypopharynx are extremely rare, and only 6 cases, all of which have been described as solid lesions and contained heterotopic gastric epithelium, could be found during our literature review.
  • We present a unique case of a hypopharyngeal foregut duplication cyst that was grossly cystic and had no heterotopic epithelium microscopically.
  • However, the hypopharyngeal location of a cyst is a clue for the diagnosis of duplication on endoscopic examination.
  • [MeSH-major] Airway Obstruction / etiology. Cysts / complications. Hypopharynx / abnormalities. Pharyngeal Diseases / complications

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  • (PMID = 17560193.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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76. Lins e Horta Hd, Guimarães FF, Rocha LO, Guimarães RE, Valadares ER: Squamous cell carcinoma of the hypopharynx in a young woman with Fanconi's anemia. Braz J Otorhinolaryngol; 2006 Nov-Dec;72(6):845-8
MedlinePlus Health Information. consumer health - Throat Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma of the hypopharynx in a young woman with Fanconi's anemia.
  • Fanconi's anemia is a rare autosomal recessive disorder characterized by congenital malformation, bone marrow failure and genomic instability, with a predisposition to develop malignancies, especially the leukemias and upper aerodigestive tract tumors.
  • In this paper we report the case of a 24-year-old woman with Fanconi's anemia who developed a squamous cell carcinoma of the hypopharynx; she had none of the traditional risk factors, such as smoking and alcohol abuse.
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Hypopharynx

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  • (PMID = 17308840.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 12
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77. Chaukar DA, Prabhudesai SG, Bhambhani NL, Pathak KA, Sanghvi VD: Differentiated thyroid cancer invading the hypopharynx: A case report. Indian J Otolaryngol Head Neck Surg; 2006 Jan;58(1):92-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiated thyroid cancer invading the hypopharynx: A case report.
  • Invasion of the upper aerodigestive tract by these cancers is infrequent and hypopharyngeal invasion is still rare.
  • We report a 51 year old man with thyroid cancer invading the hypopharynx, who was successfully managed with complete resection along with a partial pharyngectomy.

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  • [Cites] Ann Otol Rhinol Laryngol. 1977 Nov-Dec;86(6 Pt 1):751-5 [596772.001]
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  • (PMID = 23120251.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450624
  • [Keywords] NOTNLM ; Hypopharynx / papillary cancer / upper aerodigestive tract / well differentiated thyroid cancer
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78. Nishimura G, Horiuchi C, Yoshida T, Kawakami M, Yabuki K, Matsuda H, Mikami Y, Tsukuda M: Fibromatous polyp of the hypopharynx. Auris Nasus Larynx; 2006 Sep;33(3):333-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibromatous polyp of the hypopharynx.
  • We treated a patient with hypopharyngeal fibromatous polyp and speculated the mechanism of this disease.
  • The greater part of hypopharyngeal tumors is squamous cell carcinomas, and benign tumors are really uncommon.
  • Fibromatous polyp is not thought to be a true tumor, but the symptoms are almost the same as tumorous diseases, e.g., discomfort in the throat, swallowing difficulty and respiratory distress.
  • [MeSH-major] Hypopharyngeal Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Aged. Follow-Up Studies. Humans. Hypopharynx / pathology. Hypopharynx / surgery. Laryngoscopy. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16504437.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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79. Hung CC, Lee JC, Hsiao LC, Lin YS: Vocal cord immobility caused by the long-standing impaction of a fishbone in the hypopharynx. Laryngoscope; 2009 Jan;119(1):228-30
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  • [Title] Vocal cord immobility caused by the long-standing impaction of a fishbone in the hypopharynx.
  • We report a case of vocal cord immobility secondary to long-standing impaction of a fishbone in the hypopharynx for at least 9 months.
  • The diagnosis was made by computed tomography (CT) and rigid laryngoscopy because no reliable history was available.
  • [MeSH-major] Foreign Bodies / surgery. Hypopharynx / injuries. Vocal Cord Paralysis / etiology. Vocal Cord Paralysis / surgery. Vocal Cords / injuries. Wounds, Penetrating / etiology. Wounds, Penetrating / surgery

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  • (PMID = 19117334.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Taguchi T, Tsukuda M, Mikami Y, Matsuda H, Horiuchi C, Yoshida T, Nishimura G, Ishitoya J, Katori H: Concurrent chemoradiotherapy with cisplatin, 5-fluorouracil, methotrexate, and leucovorin in patients with advanced resectable squamous cell carcinoma of the larynx and hypopharynx. Acta Otolaryngol; 2006 Apr;126(4):408-13
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  • [Title] Concurrent chemoradiotherapy with cisplatin, 5-fluorouracil, methotrexate, and leucovorin in patients with advanced resectable squamous cell carcinoma of the larynx and hypopharynx.
  • In terms of larynx preservation, the present regimen appears to be useful for patients with advanced resectable squamous cell carcinoma (SCC) of the larynx and hypopharynx.
  • OBJECTIVES: To evaluate the efficacy and toxicity of concurrent chemoradiotherapy in patients with advanced resectable SCC of the larynx and hypopharynx, and to demonstrate the feasibility of larynx preservation.
  • RESULTS: The 3-year disease-specific survival rates of patients with laryngeal or hypopharyngeal SCC were 81.3% and 78%, respectively.
  • The 3-year disease-specific survival rates with larynx preservation of patients with laryngeal or hypopharyngeal SCC were 46.7% and 59%, respectively.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Hypopharynx. Laryngeal Neoplasms / drug therapy. Pharyngeal Neoplasms / drug therapy

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  • (PMID = 16608794.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 12001-76-2 / Vitamin B Complex; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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81. Rydzewski B, Golusiński P, Szewczyk A, Krokowicz A: [An unusual location of a foreign body in the posterior hypopharynx--case report]. Otolaryngol Pol; 2008;62(2):209-11
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  • [Title] [An unusual location of a foreign body in the posterior hypopharynx--case report].
  • The 64 years old female suffering from severe pain in the hypopharynx and dysphagia was introduced to the ENT Emergency Unit of the F.
  • The laryngological examination showed the piece of the needle protruding from the back wall of the hypopharynx.
  • [MeSH-major] Foreign Bodies / radiography. Hypopharynx / radiography. Needlestick Injuries / radiography

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  • (PMID = 18637449.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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82. Lou HF, Xiao SF, Zhao EM, Guo M, Wang QG, Qin Y: [Selective neck dissection on the treatment of neck metastases in 63 patients with squamous cell carcinoma of hypopharynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Mar;43(3):202-7
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  • [Title] [Selective neck dissection on the treatment of neck metastases in 63 patients with squamous cell carcinoma of hypopharynx].
  • OBJECTIVE: To analyze the prevalence and distribution of cervical node metastases in squamous cell carcinoma of hypopharynx and evaluate the efficacy of selective neck dissection (SND) on the treatment of the neck metastases.
  • METHODS: A retrospective review was performed for 63 patients with squamous cell carcinoma of hypopharynx from January 1990 to December 2004.
  • CONCLUSIONS: Lymphatic metastases was the most significant prognostic factor of hypopharyngeal squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery. Neck Dissection

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  • (PMID = 18630283.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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83. Morshed K, Szymański M, Gołabek W: Reconstruction of the hypopharynx with U-shaped pectoralis major myocutaneous flap after total pharyngo-laryngectomy. Eur Arch Otorhinolaryngol; 2005 Apr;262(4):259-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of the hypopharynx with U-shaped pectoralis major myocutaneous flap after total pharyngo-laryngectomy.
  • In 11 patients with hypopharynx and larynx cancer, total pharyngo-laryngectomy and excision of the cervical part of the esophagus and neck dissections were performed; the defects were closed with pectoralis major myocutaneous flaps.
  • [MeSH-major] Hypopharynx / surgery. Laryngectomy. Pectoralis Muscles / transplantation. Pharyngectomy. Surgical Flaps
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / surgery. Deglutition / physiology. Humans. Hypopharyngeal Neoplasms / surgery. Male. Middle Aged. Recovery of Function / physiology. Suture Techniques. Treatment Outcome

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  • [Cites] Arch Otolaryngol. 1973 Apr;97(4):340-6 [4699544.001]
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  • (PMID = 15175883.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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84. Altundag O, Gullu I, Altundag K, Yalcin S, Ozyar E, Cengiz M, Akyol F, Yucel T, Hosal S, Sozeri B: Induction chemotherapy with cisplatin and 5-fluorouracil followed by chemoradiotherapy or radiotherapy alone in the treatment of locoregionally advanced resectable cancers of the larynx and hypopharynx: results of single-center study of 45 patients. Head Neck; 2005 Jan;27(1):15-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Induction chemotherapy with cisplatin and 5-fluorouracil followed by chemoradiotherapy or radiotherapy alone in the treatment of locoregionally advanced resectable cancers of the larynx and hypopharynx: results of single-center study of 45 patients.
  • BACKGROUND: Induction chemotherapy with cisplatin and fluorouracil and radiotherapy is an effective alternative to surgery in patients with carcinoma of the larynx and hypopharynx who are treated for organ preservation.
  • METHODS: We designed a protocol to evaluate the possibility of organ preservation in patients with advanced, resectable carcinoma of the larynx and hypopharynx.
  • With a median follow-up of 13.7 months, 23 (51.1%) of all patients and 63.3% of surviving patients have had a preservation of the larynx or hypopharynx and remain disease free.
  • CONCLUSION: Organ preservation, with multimodality treatment, may be achievable in some of the patients with resectable, advanced larynx or hypopharynx cancers without apparent compromise of survival.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / therapy. Hypopharyngeal Neoplasms / therapy. Laryngeal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Cisplatin / adverse effects. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Male. Middle Aged. Neck Dissection / methods. Neoplasm Recurrence, Local. Neoplasm, Residual / surgery. Radiotherapy, Adjuvant. Salvage Therapy. Treatment Outcome

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  • [Copyright] Copyright 2004 Wiley Periodicals, Inc.
  • (PMID = 15515158.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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85. Wadasaki K, Matsuura K, Murakami Y, Kenjo M, Kaneyasu Y, Fujita M, Ito K, Tatsukawa R, Takeno Y, Hirakawa K: [Treatment results of concurrent chemoradiotherapy with CDDP or CDGP plus 5-FU for carcinoma of the oropharynx and hypopharynx]. Gan To Kagaku Ryoho; 2007 Sep;34(9):1393-6
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  • [Title] [Treatment results of concurrent chemoradiotherapy with CDDP or CDGP plus 5-FU for carcinoma of the oropharynx and hypopharynx].
  • Twenty-eight patients with oropharyngeal or hypopharyngeal carcinoma received concurrent chemoradiotherapy with CDDP or CDGP plus 5-FU between January 2001 and April 2006.
  • Concurrent chemoradiotherapy with CDDP or CDGP plus 5-FU seemed to be effective for advanced carcinomas of the oropharynx and hypopharynx.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Hypopharyngeal Neoplasms / therapy. Oropharyngeal Neoplasms / therapy

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  • (PMID = 17876135.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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86. Chu PY, Chang SY, Huang JL, Tai SK: Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol; 2010 May-Jun;31(3):168-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx.
  • PURPOSE: The aim of the present study was to compare the incidence, patterns, and survival of second primary malignancy (SPM) in patients with squamous cell carcinoma of the larynx (LSCC) and hypopharynx (HPSCC).
  • Data including age, sex, risk factors, subsites and TNM stage of primary tumor, treatment, site and incidence of SPM, and prognosis were collected from medical charts.
  • The factors influencing the appearance of SPM included early T stage, tobacco use, and less tumor recurrence.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / surgery. Neoplasms, Second Primary / surgery

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20015735.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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87. Walor D, Berdon W, Anderson N, Holt PD, Fox M: Gaseous distention of the hypopharynx and cervical esophagus with nasal CPAP: a mimicker of pharyngeal perforation and esophageal atresia. Pediatr Radiol; 2005 Dec;35(12):1196-8
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  • [Title] Gaseous distention of the hypopharynx and cervical esophagus with nasal CPAP: a mimicker of pharyngeal perforation and esophageal atresia.
  • Gaseous distention of the hypopharynx is also common.
  • OBJECTIVE: To determine the incidence of hypopharyngeal distention in infants on CPAP.
  • MATERIALS AND METHODS: We performed a retrospective review of the chest radiographs of 57 premature infants treated with CPAP during a 4-week period to find the presence and degree of hypopharyngeal distention.
  • RESULTS: Of the 57 radiographs, 14 (25%) revealed gaseous distention of the hypopharynx and/or cervical esophagus.
  • CONCLUSION: Awareness that CPAP-related hypopharyngeal distention is common should help radiologists avoid erroneous consideration of esophageal atresia or hypopharyngeal perforation.
  • [MeSH-major] Continuous Positive Airway Pressure / adverse effects. Esophageal Atresia / diagnosis. Esophagus / pathology. Hypopharynx / pathology. Pharyngeal Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Dilatation, Pathologic / etiology. Humans. Incidence. Infant, Newborn. Infant, Premature. Infant, Very Low Birth Weight. Intensive Care Units, Neonatal. Radiography. Retrospective Studies. Treatment Outcome

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  • [Cites] Crit Care Med. 1975 Mar-Apr;3(2):76-8 [1098852.001]
  • [Cites] Semin Neonatol. 2002 Oct;7(5):379-89 [12464500.001]
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  • (PMID = 16096824.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Damascelli B, Patelli G, Tichá V, Di Tolla G, Frigerio LF, Garbagnati F, Lanocita R, Marchianò A, Spreafico C, Mattavelli F, Bruno A, Zunino F: Feasibility and efficacy of percutaneous transcatheter intraarterial chemotherapy with paclitaxel in albumin nanoparticles for advanced squamous-cell carcinoma of the oral cavity, oropharynx, and hypopharynx. J Vasc Interv Radiol; 2007 Nov;18(11):1395-403
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  • [Title] Feasibility and efficacy of percutaneous transcatheter intraarterial chemotherapy with paclitaxel in albumin nanoparticles for advanced squamous-cell carcinoma of the oral cavity, oropharynx, and hypopharynx.
  • MATERIALS AND METHODS: Sixty previously untreated patients with locally advanced squamous-cell carcinoma (SCC) of the oral cavity, oropharynx, or hypopharynx in stage T3/4 and any nodal stage received two to four cycles of nanoparticle albumin-bound paclitaxel by infusion into the external carotid artery or one of its branches, without premedication, at an initial dose of 230 mg/m2 and subsequently a reduced dose of 150 mg/m2.

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  • (PMID = 18003990.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Carriers; 0 / Serum Albumin; P88XT4IS4D / Paclitaxel
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89. Dubsky PC, Stift A, Rath T, Kornfehl J: Salvage surgery for recurrent carcinoma of the hypopharynx and reconstruction using jejunal free tissue transfer and pectoralis major muscle pedicled flap. Arch Otolaryngol Head Neck Surg; 2007 Jun;133(6):551-5
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  • [Title] Salvage surgery for recurrent carcinoma of the hypopharynx and reconstruction using jejunal free tissue transfer and pectoralis major muscle pedicled flap.
  • OBJECTIVE: To evaluate patients undergoing salvage surgery after recurrent squamous cell carcinoma of the hypopharynx.
  • PATIENTS: A total of 8 consecutive patients with recurrent hypopharyngeal squamous cell carcinoma.
  • RESULTS: The cohort of patients was heavily pretreated owing to late stages of disease at diagnosis.
  • CONCLUSIONS: Jejunal transfer and pectoralis major muscle flap were carried out in a single, reconstructive procedure after salvage resection in hypopharyngeal carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery. Jejunum / transplantation. Neoplasm Recurrence, Local / surgery. Pectoralis Muscles / transplantation. Reconstructive Surgical Procedures / methods. Salvage Therapy. Surgical Flaps

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  • (PMID = 17576905.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Nakamura K, Shioyama Y, Sasaki T, Ohga S, Saku M, Urashima Y, Yoshitake T, Nakashima T, Kuratomi Y, Komune S, Terashima H, Honda H: Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx. Int J Radiat Oncol Biol Phys; 2005 Jul 1;62(3):680-3
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  • [Title] Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx.
  • PURPOSE: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity.
  • Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery.
  • METHODS AND MATERIALS: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy.
  • Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer.
  • CONCLUSIONS: A majority of patients with early hypopharyngeal cancer was curable.
  • However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / radiotherapy. Hypopharyngeal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Laryngectomy. Male. Middle Aged. Neoplasm Staging. Neoplasms, Multiple Primary. Pharyngectomy. Radiotherapy Dosage. Salvage Therapy. Survival Rate

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  • (PMID = 15936545.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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91. Palencár D, Hedera J, Fedeles J, Dolezal J, Pind'ák D: Reconstruction of a circular defect of the hypopharynx and cervical part of esophagus by a free jejunal flap (case report). Acta Chir Plast; 2005;47(2):35-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of a circular defect of the hypopharynx and cervical part of esophagus by a free jejunal flap (case report).
  • Reconstruction of the hypopharynx and esophagus is desirable in cases of congenital deformities, corrosive injuries, or defects after tumor resections.
  • In this article, the authors present a case of complete hypopharynx closure in an oncology patient with a larynx carcinoma.
  • The patient underwent laser resection of the tumor followed by radiotherapy and chemotherapy.
  • During the course of healing the patient developed complete hypopharynx and cervical esophagus closure.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharynx / surgery. Jejunum / transplantation. Laryngeal Neoplasms / surgery

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  • (PMID = 16035154.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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92. Kimura T, Mukai M, Shiotani A, Moro K, Ikeda A, Okada Y: Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass. Arch Pathol Lab Med; 2005 Apr;129(4):e94-6
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  • [Title] Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass.
  • We report a case of basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component in an 82-year-old man.
  • The tumor (4.0 x 2.5 x 2.2 cm) was a pedunculated polypoid mass that was attached to the left pyriform sinus.
  • Histologically, most (70%) of the tumor was composed of malignant spindle cell proliferation, and the rest (30%) was basaloid squamous carcinoma.
  • The preoperative histologic diagnosis was difficult because the endoscopic biopsy specimens showed only spindle cell proliferation.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology

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  • (PMID = 15794698.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Tilly N, Johansson J, Isacsson U, Medin J, Blomquist E, Grusell E, Glimelius B: The influence of RBE variations in a clinical proton treatment plan for a hypopharynx cancer. Phys Med Biol; 2005 Jun 21;50(12):2765-77
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  • [Title] The influence of RBE variations in a clinical proton treatment plan for a hypopharynx cancer.
  • The treatment plan is evaluated by RBE weighted dose volume histograms (DVHs) and the calculation of tumour control probability (TCP) and normal tissue complication probability (NTCP) values.
  • The variable RBE correction yields DVHs for the clinical target volumes (CTVs), a primary advanced hypopharynx cancer and subclinical disease in the lymph nodes, that are slightly higher than those achieved by multiplying the absorbed dose with RBE=1.1.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / radiotherapy. Protons / therapeutic use

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  • (PMID = 15930601.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protons
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94. Yom SS, Machtay M, Biel MA, Sinard RJ, El-Naggar AK, Weber RS, Rosenthal DI: Survival impact of planned restaging and early surgical salvage following definitive chemoradiation for locally advanced squamous cell carcinomas of the oropharynx and hypopharynx. Am J Clin Oncol; 2005 Aug;28(4):385-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival impact of planned restaging and early surgical salvage following definitive chemoradiation for locally advanced squamous cell carcinomas of the oropharynx and hypopharynx.
  • METHODS: A retrospective review was performed for patients with resectable T3/4 cancers of the oropharynx and hypopharynx treated with RT +/- chemotherapy who underwent planned restaging clinically, radiographically (CT or MRI), and by direct laryngoscopy with biopsy at 4 to 8 weeks post-RT.
  • Neck dissection was performed at time of restaging in patients with primary tumor control and initial N2/N3 neck disease or persistent lymphadenopathy.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Hypopharyngeal Neoplasms / mortality. Hypopharyngeal Neoplasms / pathology. Neoplasm Recurrence, Local / surgery. Oropharyngeal Neoplasms / mortality. Oropharyngeal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy / methods. Carboplatin / administration & dosage. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Laryngoscopy. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Palliative Care. Radiation Dosage. Radiation Injuries / epidemiology. Remission Induction. Retrospective Studies. Salvage Therapy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16062081.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; U3P01618RT / Fluorouracil
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95. Wang HM, Hsueh CT, Wang CS, Chen IH, Liao CT, Tsai MH, Yeh SP, Chang JT: Phase II trial of cisplatin, tegafur plus uracil and leucovorin as neoadjuvant chemotherapy in patients with squamous cell carcinoma of the oropharynx and hypopharynx. Anticancer Drugs; 2005 Apr;16(4):447-53
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  • [Title] Phase II trial of cisplatin, tegafur plus uracil and leucovorin as neoadjuvant chemotherapy in patients with squamous cell carcinoma of the oropharynx and hypopharynx.
  • We evaluated the efficacy and toxicity of cisplatin, tegafur plus uracil and leucovorin as neoadjuvant chemotherapy for locally advanced squamous cell carcinoma (SCC) of the oropharynx and hypopharynx.
  • Evaluation after 3 cycles led to chemotherapy termination if primary tumor responses were less than partial responses.
  • We concluded that the outpatient PUL regimen was a moderately effective, less-toxic neoadjuvant chemotherapy for SCC of the oropharynx and hypopharynx.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Hypopharyngeal Neoplasms / drug therapy. Neoadjuvant Therapy. Oropharyngeal Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Female. Humans. Leucovorin / administration & dosage. Male. Maximum Tolerated Dose. Middle Aged. Neoplasm Staging. Survival Rate. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 15746582.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin
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96. Lü Z, Ma X, Pan Xg, Liu D, Luan X: [The expression and significance of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of hypopharynx]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Nov;22(21):961-4, 967
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The expression and significance of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of hypopharynx].
  • OBJECTIVE: To investigate the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of hypopharynx and reveal the correlation of the major clinicopathological parameters and prognosis.
  • METHOD: Samples of 48 hypopharyngeal carcinoma and 10 normal hypopharyngeal tissue were detected by immunohistochemistry method (SP method) for urokinase-type plasminogen activator (uPA) and its receptor (uPAR).
  • The correlation between the expression of urokinase-type plasminogen activator and its receptor and the major clinicopathological parameters of hypopharyngeal carcinoma were analyzed by rank sum test and Spearman correlation analysis.
  • RESULT: In 48 hypopharyngeal carcinoma specimens, positive expression rates of uPA and uPAR were 77.1% and 68.75% respectively, which were significantly higher than in normal tissues (P < 0.01).
  • The uPA and uPAR positive expression was correlated with pathological grading, lymph node metastases and growth mode of hypopharyngeal carcinoma.
  • CONCLUSION: The positive expression of uPA and uPAR in hypopharyngeal carcinoma were significantly higher than in normal tissues. uPAR is a new independent and strong biologically prognostic factors, which positive expression may be a powerful aid in evaluating metastatic potential and High-Risk patients in early stage of hypopharynx carcinoma ryngeal carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Hypopharyngeal Neoplasms / metabolism. Receptors, Urokinase Plasminogen Activator / metabolism. Urokinase-Type Plasminogen Activator / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 19157142.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Receptors, Urokinase Plasminogen Activator; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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97. Ozer E, Grecula JC, Agrawal A, Rhoades CA, Young DC, Schuller DE: Long-term results of a multimodal intensification regimen for previously untreated advanced resectable squamous cell cancer of the oral cavity, oropharynx, or hypopharynx. Laryngoscope; 2006 Apr;116(4):607-12
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  • [Title] Long-term results of a multimodal intensification regimen for previously untreated advanced resectable squamous cell cancer of the oral cavity, oropharynx, or hypopharynx.
  • BACKGROUND: Long-term disease control of an intensified treatment regimen for previously untreated stage III and IV resectable oral cavity, oropharyngeal, or hypopharyngeal squamous cell carcinoma was analyzed.
  • METHODS: Forty-three patients with previously untreated, advanced stage, resectable squamous carcinomas of the oral cavity, oropharynx, or hypopharynx were enrolled in a prospective phase II institutional clinical trial at a tertiary care National Cancer Institute-designated comprehensive cancer center.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / therapy. Mouth Neoplasms / therapy. Oropharyngeal Neoplasms / therapy. Otorhinolaryngologic Surgical Procedures / methods

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  • (PMID = 16585867.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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98. Honda K, Tanaka S, Tamura Y, Asato R, Hirano S, Ito J: Vocal cord fixation caused by an impacted fish bone in hypopharynx: report of a rare case. Am J Otolaryngol; 2007 Jul-Aug;28(4):257-9
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  • [Title] Vocal cord fixation caused by an impacted fish bone in hypopharynx: report of a rare case.
  • We report a rare case of vocal cord fixation caused by a fish bone in the hypopharynx.
  • The diagnosis was suggested by a clinical history and confirmed by a computed tomography scan.
  • [MeSH-major] Foreign Bodies / diagnosis. Hoarseness / etiology. Hypopharynx / injuries. Vocal Cords / injuries. Wounds, Penetrating / diagnosis
  • [MeSH-minor] Aged. Animals. Diagnosis, Differential. Female. Fishes. Humans. Laryngoscopy / methods. Tomography, X-Ray Computed

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  • (PMID = 17606043.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Distel LV, Fickenscher R, Dietel K, Hung A, Iro H, Zenk J, Nkenke E, Büttner M, Niedobitek G, Grabenbauer GG: Tumour infiltrating lymphocytes in squamous cell carcinoma of the oro- and hypopharynx: prognostic impact may depend on type of treatment and stage of disease. Oral Oncol; 2009 Oct;45(10):e167-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumour infiltrating lymphocytes in squamous cell carcinoma of the oro- and hypopharynx: prognostic impact may depend on type of treatment and stage of disease.
  • he purpose of this study was to evaluate the prognostic influence of various subtypes of tumour infiltrating lymphocytes (TIL) in head and neck cancer, in particular the potential influence of regulatory T cells (Treg) in relation to different treatment modalities was addressed.
  • A total of 115 patients with squamous cell carcinoma of the oro- and hypopharynx were selected.
  • [MeSH-major] Carcinoma, Squamous Cell / immunology. Hypopharyngeal Neoplasms / immunology. Lymphocytes, Tumor-Infiltrating / immunology. Oropharyngeal Neoplasms / immunology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. T-Lymphocytes, Regulatory / immunology

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  • (PMID = 19576838.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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100. Pivot X, Magné N, Guardiola E, Poissonnet G, Dassonville O, Francoual M, Formento JL, Bensadoun RJ, Demard F, Schneider M, Milano G: Prognostic impact of the epidermal growth factor receptor levels for patients with larynx and hypopharynx cancer. Oral Oncol; 2005 Mar;41(3):320-7
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  • [Title] Prognostic impact of the epidermal growth factor receptor levels for patients with larynx and hypopharynx cancer.
  • The aim of this study was to analyse prognostic factors for disease free interval (DFI) and overall survival (OS) among patients with larynx and hypopharynx cancer requiring a total laryngectomy.
  • The studied potential prognostic factors were age, gender, performans status, primary tumor localization, T status, N status, tumor volume and tumoral EGFR level (fmol/mg protein).
  • The multivariate analysis showed that both N status and tumor volume were significant for DFI and OS.
  • Among this group, patients with tumor EGFR levels lower and higher than 100 fmol/mg protein had 53% versus 22% and 51% versus 18% 5-year of DFI and OS rates, respectively (Log rank test: p = 0.001 and 0.0001).
  • [MeSH-major] Biomarkers, Tumor / analysis. Hypopharyngeal Neoplasms / chemistry. Laryngeal Neoplasms / chemistry. Receptor, Epidermal Growth Factor / analysis

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  • (PMID = 15743695.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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