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1. Leti Acciaro A, Gabrieli R, Landi A: A rare case of acral myxoinflammatory fibroblastic sarcoma at the hand. Musculoskelet Surg; 2010 May;94(1):53-7
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  • [Title] A rare case of acral myxoinflammatory fibroblastic sarcoma at the hand.
  • Most of the soft tissue tumefactions of the distal extremities are benign.
  • This neoplasm has a propensity for digits, presents a low rate of metastasis and is characterized by a high rate of local multiple and aggressive recurrence.

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  • (PMID = 20066525.001).
  • [ISSN] 2035-5114
  • [Journal-full-title] Musculoskeletal surgery
  • [ISO-abbreviation] Musculoskelet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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2. Batinac T, Zamolo G, Coklo M, Hadzisejdic I: Possible key role of granzyme B in keratoacanthoma regression. Med Hypotheses; 2006;66(6):1129-32
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  • Within the past few years, it has become evident that the molecular events regulating cell survival and apoptosis are important contributors to the overall kinetics of benign and malignant cell growth.
  • On the other hand, insufficient activation of cytotoxic T lymphocytes and decreased release or activity of granzyme B could be responsible for squamous cell-carcinoma progression and occasional aggressive behavior in keratoacanthomas.
  • [MeSH-major] Carcinoma, Squamous Cell / immunology. Keratoacanthoma / immunology. Models, Immunological. Neoplasm Regression, Spontaneous / immunology. Serine Endopeptidases / immunology. Signal Transduction / immunology. T-Lymphocytes / immunology

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  • (PMID = 16497444.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] EC 3.4.21.- / GZMB protein, human; EC 3.4.21.- / Granzymes; EC 3.4.21.- / Serine Endopeptidases
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3. Le Bellec Y, Asfazadourian H: [Bizarre parosteal osteochondromatous proliferation (Nora's lesion). Two case reports]. Chir Main; 2005 Oct;24(5):265-9
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  • [Transliterated title] Prolifération ostéocartilagineuse parostéale bizarre ou tumeur de Nora. A propos de deux cas.
  • It is a benign lesion, characterized by a proliferation of chondroid, bony and fibrous tissues.
  • The authors report two cases involving the hand.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Reoperation. Time Factors

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  • (PMID = 16277154.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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4. Nakatsura T, Nishimura Y: Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma. BioDrugs; 2005;19(2):71-7
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  • On the other hand, detection of PIVKA-II shows a lower false-positivity, but is not always sensitive enough to detect low levels secreted by small HCCs.
  • Expression of GPC3 mRNA and protein was evident in tumor cells from >80% of patients with melanoma and melanocytic nevus, which is a common benign lesion.
  • [MeSH-major] Antigens, Neoplasm. Carcinoma, Hepatocellular / diagnosis. Heparan Sulfate Proteoglycans. Melanoma / diagnosis. Molecular Diagnostic Techniques / trends

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  • (PMID = 15807627.001).
  • [ISSN] 1173-8804
  • [Journal-full-title] BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
  • [ISO-abbreviation] BioDrugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Glypicans; 0 / Heparan Sulfate Proteoglycans
  • [Number-of-references] 59
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5. Abdalla RJ, Cohen M, Nóbrega J, Forgas A: SYNOVIAL GIANT CELL TUMOR OF THE KNEE. Rev Bras Ortop; 2009 Jan;44(5):437-40
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  • Synovial giant cell tumor is a benign neoplasm, rarely reported in the form of malignant metastasis.
  • Synovial giant cell tumor most frequently occurs on the hand, and, most uncommon, on the ankle and knee.

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  • (PMID = 27004193.001).
  • [ISSN] 2255-4971
  • [Journal-full-title] Revista brasileira de ortopedia
  • [ISO-abbreviation] Rev Bras Ortop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC4783680
  • [Keywords] NOTNLM ; Giant cell tumor / Knee / Neoplasm / Synovial
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6. Ishida M, Egawa S, Aoki T, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Unno M, Moriya T, Horii A, Furukawa T: Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas. Pancreas; 2007 Nov;35(4):348-52
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  • OBJECTIVES: Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas encompasses a spectrum of neoplasms with both morphological and immunohistochemical variations of mucin glycoproteins.
  • Characteristically, the gastric-type IPMNs were likely to be diagnosed as benign, to be confined to branch ducts, and to have fair prognoses.
  • On the other hand, the intestinal-type IPMNs were likely to be diagnosed as malignant, occupy the main duct, and have poor prognoses.
  • [MeSH-minor] Aged. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Mucin 5AC. Mucin-1 / analysis. Mucin-2. Mucins / analysis. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 18090241.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins
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7. Lindegaard J, Heegaard S, Toft PB, Nysom K, Prause JU: Malignant transformation of a medulloepithelioma of the optic nerve. Orbit; 2010 Jun;29(3):161-4
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  • Visual acuity was hand motions.
  • A benign non-teratoid medulloepithelioma of the optic nerve was surgically removed.
  • This is the first case described of a benign medulloepithelioma of the optic nerve, later transforming into a malignant tumour.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumors, Primitive / pathology. Optic Nerve Neoplasms / pathology

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  • (PMID = 20497085.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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8. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • [Title] Chondroid syringoma of the hand: a rare localization.
  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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9. De Corso E, Politi M, Marchese MR, Pirronti T, Ricci R, Paludetti G: Advanced giant cell reparative granuloma of the mandible: radiological features and surgical treatment. Acta Otorhinolaryngol Ital; 2006 Jun;26(3):168-72
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  • Giant cell reparative granuloma accounts for 1%-7% of all benign lesions of the jaw.
  • [MeSH-minor] Adult. Female. Humans. Ilium / transplantation. Neoplasm Staging

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  • (PMID = 17063987.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
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10. Furukawa H, Ikuma H, Asakura-Yokoe K, Uesaka K: Preoperative staging of biliary carcinoma using 18F-fluorodeoxyglucose PET: prospective comparison with PET+CT, MDCT and histopathology. Eur Radiol; 2008 Dec;18(12):2841-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On the other hand, eight benign lesions did not show any specific accumulation.
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasm Staging. Patient Selection. Preoperative Care. Prospective Studies. Radiopharmaceuticals. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 18509655.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Controlled Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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11. Jang HJ, Kim TK, Wilson SR: Imaging of malignant liver masses: characterization and detection. Ultrasound Q; 2006 Mar;22(1):19-29
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  • On the other hand, metastasis shows prompt brief arterial hypervascularity, with either a rim or diffuse pattern and rapid washout, seen as perfusion defects during the portal venous phase.
  • This pattern of complete rapid washout of metastases within the homogeneously enhanced background liver parenchyma can improve their detection and also improve differentiation from hepatocellular carcinoma or benign focal lesions.
  • All malignant lesions generally show negative enhancement or washout during the extended portal venous phase, and this pattern is useful to differentiate them from benign lesions.
  • [MeSH-minor] Cholangiocarcinoma / ultrasonography. Hemangioendothelioma / ultrasonography. Humans. Lymphoma / ultrasonography. Microbubbles. Neoplasm Metastasis

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  • (PMID = 16641790.001).
  • [ISSN] 0894-8771
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 26
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12. Zhang YX, Chen HL, Ye B, Yang F, Yu LY: [Study on expression and methylation of caveolin 1 gene in non-small cell lung cancers]. Zhonghua Bing Li Xue Za Zhi; 2008 May;37(5):300-4
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  • METHODS: Immunohistochemistry and quanta Qd600 staining were used to detect the expression of Cav-1 in tissues from benign lung lesions (n = 17) and NSCLC (n = 123).
  • On the other hand, Cav-1 protein immunoreactivity was remarkably higher in advanced tumor stage: 72.7% in stage III A + III B, compared with 9.4% in stage I A + I B and 38.3% in stage II A + II B (P = 0.001).
  • [MeSH-minor] Aged. DNA Methylation. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging / methods. Somatoform Disorders

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  • (PMID = 18956646.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Caveolin 1
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13. Liao CH, Chueh SC, Lai MK, Hsiao PJ, Chen J: Laparoscopic adrenalectomy for potentially malignant adrenal tumors greater than 5 centimeters. J Clin Endocrinol Metab; 2006 Aug;91(8):3080-3
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  • We report a series of LA or hand-assisted LA for large (>5 cm) adrenal tumors.
  • Final pathology revealed eight malignant (four adrenocortical carcinomas and four metastatic carcinomas) and 31 benign tumors (14 cortical adenomas, eight pheochromocytomas, six myelolipomas, and three ganglioneuromas).
  • A hand-assisted device was used in 10 patients.
  • Only the tumor size was larger and length of postoperative hospital stay longer for those in the hand-assisted group.
  • Hand-assisted LA is a good alternative to open conversion if a difficult dissection is encountered intraoperatively.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adolescent. Adult. Aged. Child. Child, Preschool. Ganglioneuroma / pathology. Ganglioneuroma / surgery. Humans. Middle Aged. Myelolipoma / pathology. Myelolipoma / surgery. Neoplasm Metastasis. Pheochromocytoma / pathology. Pheochromocytoma / surgery. Prognosis. Survival Rate

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  • [CommentIn] Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):210-1 [17262068.001]
  • (PMID = 16720665.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Toma R, Ferris S, Coombs CJ, Johnstone BR, McCombe DB: Lipoblastoma: An important differential diagnosis of tumours of the hand in children. J Plast Surg Hand Surg; 2010 Nov;44(4-5):257-9
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  • [Title] Lipoblastoma: An important differential diagnosis of tumours of the hand in children.
  • Lipoblastoma is a rare benign neoplasm of infancy and childhood with the potential for locally invasive, rapid growth.
  • We present two cases of lipoblastoma of the hand that were excised within a three month period with no evidence of recurrence at 14, and 12, months respectively.
  • [MeSH-major] Hand. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 21446824.001).
  • [ISSN] 2000-6764
  • [Journal-full-title] Journal of plastic surgery and hand surgery
  • [ISO-abbreviation] J Plast Surg Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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15. Carpino F, Pezzoli F, Petrozza V, Carpino G, Evangelista A, Mutone D, Reali M, Gaudio C: Angiosarcoma of the heart: structural and ultrastructural study. Eur Rev Med Pharmacol Sci; 2005 Jul-Aug;9(4):231-40
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  • Nearly 70% of primary cardiac tumours are benign, the majority of which are represented by myxomas.
  • The most frequent primary cardiac neoplasm is the angiosarcoma that represents 31% of primary cardiac malignant.
  • On the other hand, some less-differentiated solid areas were present and irregularly surrounded the differentiated vascular areas.

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  • (PMID = 16128044.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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16. Nalbantoglu U, Gereli A, Kocaoglu B, Aktas S: Fibro-osseous pseudotumor of the digits: a rare tumor in an unusual location. J Hand Surg Am; 2008 Feb;33(2):273-6
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  • Fibro-osseous pseudotumor of the digits (FOPT) is a rare benign lesion of the hand.
  • When FOPT originates in an unusual anatomic region (other than the digits), it can imitate a malignant neoplasm, and consequently surgical treatment can be improper.

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  • (PMID = 18294555.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Browne TJ, Fletcher CD: Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology; 2006 Mar;48(4):453-61
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  • AIMS: To describe 13 new cases of a rare soft tissue neoplasm currently known as haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL) and to further its characterization.
  • Twelve of 13 lesions were located in the ankle/foot region; one involved the hand.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16487368.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 9011-92-1 / Hemosiderin
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18. Sayed DM, el-Attar MM, Hussein AA: Evaluation of flow cytometric immunophenotyping and DNA analysis for detection of malignant cells in serosal cavity fluids. Diagn Cytopathol; 2009 Jul;37(7):498-504
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  • The mean of DI differed statistically in patients with malignant effusions than in benign one.
  • On the other hand, although DNA ploidy examination had better sensitivity; it had no advantage over conventional cytopathological examination in identification of malignant cells.
  • [MeSH-major] DNA, Neoplasm / genetics. Flow Cytometry / methods. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neoplasms / genetics. Neoplasms / metabolism. Neoplasms / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19217060.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neoplasm Proteins
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19. Kalajian AH, Cely SJ, Malone JC, Burruss JB, Callen JP: Hydroxyurea-associated dermatomyositis-like eruption demonstrating abnormal epidermal p53 expression: a potential premalignant manifestation of chronic hydroxyurea and UV radiation exposure. Arch Dermatol; 2010 Mar;146(3):305-10
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  • While hydroxyurea-associated nonmelanoma skin cancers are known to be associated with significant morbidity and occasional mortality, to date, dermatomyositis-like eruption has been considered a benign entity, other than its ability to mimic true dermatomyositis leading to inappropriate immunosuppression.
  • Accordingly, we suggest that dermatomyositis-like eruption, previously considered a benign entity, may represent a premalignant precursor of hydroxyurea-associated nonmelanoma skin cancers warranting discontinuation of hydroxyurea therapy.
  • [MeSH-minor] Aged, 80 and over. DNA, Neoplasm / genetics. Diagnosis, Differential. Drug Eruptions / etiology. Drug Eruptions / pathology. Epidermis / metabolism. Epidermis / pathology. Fatal Outcome. Female. Hand Dermatoses / chemically induced. Hand Dermatoses / pathology. Humans. Nucleic Acid Synthesis Inhibitors / adverse effects


20. Ma L, Liu FR, Zhang SL: [Detection of circulating hypermethylated tumor-specific RASSF1A DNA in ovarian cancer patients]. Zhonghua Bing Li Xue Za Zhi; 2005 Dec;34(12):785-7
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  • RESULTS: The RASSF1A gene was not methylated in peripheral blood samples from 51 normal patients and 51 patients with benign ovarian tumors.
  • On the other hand, hypermethylation of RASSF1A gene was more frequently encountered in stage III and IV than stage I and II tumors (P < 0.05).
  • [MeSH-minor] Carcinoma, Endometrioid / blood. Carcinoma, Endometrioid / pathology. Cystadenocarcinoma, Mucinous / blood. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Serous / blood. Cystadenocarcinoma, Serous / pathology. Female. Humans. Neoplasm Staging

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  • (PMID = 16545186.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins
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21. Scope A, Tabanelli M, Busam KJ, Rabinovitz H, Braun RP, Marghoob AA: Dispelling the myth of the "benign hair sign" for melanoma. J Am Acad Dermatol; 2007 Mar;56(3):413-6
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  • [Title] Dispelling the myth of the "benign hair sign" for melanoma.
  • The vast majority of melanocytic lesions with hair, such as congenital melanocytic nevi, are benign.
  • However, there is a notion that the presence of one or more hairs in a melanocytic lesion is confirmatory for the benign nature of the lesion.
  • Thus, integrating all clinical and dermoscopic findings, rather than relying on a single criterion for the lesion at hand should guide clinicians to the correct diagnosis.
  • [MeSH-major] Hair / pathology. Melanoma / pathology. Neoplasm Invasiveness. Skin Neoplasms / pathology

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  • (PMID = 17156892.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Ben Brahim E, Sfia M, Tangour M, Makhlouf R, Cribier B, Chatti S: Malignant eccrine spiradenoma: a new case report. J Cutan Pathol; 2010 Apr;37(4):478-81
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  • In most cases, it arises in pre-existing benign eccrine spiradenoma.
  • Microscopically, there were two distinct morphological components: a benign eccrine spiradenoma and a malignant eccrine spiradenoma of low grade with extensive necrosis.
  • Extensive sampling to look for a probable previously benign component is necessary.
  • In the other hand, malignant changes can be easily missed without adequate sampling.
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 19614990.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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23. Ji Y, Zhu XZ, Lou WH, Wang DQ, Jin DY, Zeng MS, Zeng HY: [Clinicopathologic analysis of 92 cases of pancreatic cystic neoplasm]. Zhonghua Bing Li Xue Za Zhi; 2007 Mar;36(3):160-5
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  • [Title] [Clinicopathologic analysis of 92 cases of pancreatic cystic neoplasm].
  • METHODS: Ninety-two cases of cystic neoplasm of pancreas were retrieved from the Department archival file during the period from 1999 to 2005.
  • They consisted of intraductal papillary mucinous neoplasm (36/92), serous cystic neoplasm (18/92), solid pseudopapillary tumor (18/92), mucinous cystic neoplasm (14/92), cystic pancreatic ductal adenocarcinoma (4/92) and cystic pancreatic endocrine neoplasm (2/92).
  • In general, serous cystic neoplasm expressed MUC1, while mucinous cystic neoplasm was positive for MUC-5AC, intraductal papillary mucinous neoplasm for MUC-2 and cystic pancreatic ductal adenocarcinoma for MUC-1.
  • On the other hand, solid pseudopapillary tumor expressed alpha-antitrypsin, alpha-antichymotrypsin, vimentin and progesterone receptor.
  • Two-thirds of pancreatic cystic neoplasms are premalignant or malignant and warrant surgical resection, whereas the remaining one-third (including pseudocyst and serous cystadenoma) are benign and can be treated conservatively.

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  • (PMID = 17535681.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1
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24. Chang YJ, Mittal V, Remine S, Manyam H, Sabir M, Richardson T, Young S: Correlation between clinical and histological findings in parathyroid tumors suspicious for carcinoma. Am Surg; 2006 May;72(5):419-26
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  • Among 168 patients who underwent parathyroid excision, 14 (8.3%) had hyperplasia of the parathyroid, 121 (72%) had benign adenoma, 25 (14.8%) had other benign lesions, and 8 (4.7%) patients had primary carcinoma of the parathyroid confirmed by pathology.
  • Our mean serum calcium level was 11.57 mg/dL, which was lower than the mean level (12 mg/dL) for benign hyperparathyroidism.
  • On the other hand, 17 patients with benign histology had tumors greater than 3 cm, and an additional 18 had palpable masses on physical examination.
  • [MeSH-minor] Adenoma / blood. Adenoma / diagnosis. Adenoma / surgery. Aged, 80 and over. Calcium / blood. Female. Humans. Hyperparathyroidism / etiology. Male. Middle Aged. Mitosis. Neoplasm Invasiveness. Parathyroidectomy

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  • (PMID = 16719197.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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25. Kujala S, Kallioinen M, Forsman M, Ryhänen J: Intraosseous schwannoma of the middle phalanx. Scand J Plast Reconstr Surg Hand Surg; 2006;40(5):318-20
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  • Intraosseous schwannoma is an extremely rare, benign neoplasm.
  • Only a few cases involving the bones of the hand have been reported, and none of these cases has involved middle phalanx.

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  • (PMID = 17065125.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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26. Rubin G, Wolovelsky A, Rinott M, Rozen N: Osteoid osteoma of the hamate: an unusual cause of ulnar-sided wrist pain. Orthopedics; 2010 Jul;33(7):513
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  • Osteoid osteoma is a benign skeletal neoplasm of unknown etiology that is composed of osteoid and woven bone.
  • Its incidence is 11% of benign tumors and 3% of all primary bone tumors, with 6% to 13% of all cases occurring in the hand.

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20608627.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Ozalp T, Yercan H, Okçu G, Ozdemir O, Coskunol E, Bégué T, Calli I: [Giant-cell tumor of the hand: midterm results in five patients]. Rev Chir Orthop Reparatrice Appar Mot; 2007 Dec;93(8):842-7
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  • [Title] [Giant-cell tumor of the hand: midterm results in five patients].
  • [Transliterated title] Tumeur à cellules géantes de la main: résultats du traitement: 5 cas au recul moyen de 7, 8 ans.
  • PURPOSE OF THE STUDY: Giant-cell bone tumors are benign but have great potential for recurrence.
  • Frequently observed in epiphyseal areas of tubular bones, these tumors are rarely found in hand localizations.
  • We examined the characteristic features of giant-cell tumors of the hand and analyzed the pertinence of surgical treatment.
  • CASE REPORTS: Five patients treated between 1973 and 2000 for giant-cell tumors involving the hand bones were reviewed retrospectively.
  • DISCUSSION: Treatment of giant-cell tumors involving the hand bones is designed to eradicate the tumor and also protect hand function while keeping in mind the aggressive nature of these benign tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumors / surgery. Hand Bones / surgery
  • [MeSH-minor] Adult. Aged. Amputation. Bone Transplantation. Curettage. Female. Finger Phalanges / surgery. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Soft Tissue Neoplasms / surgery. Thumb / surgery. Time Factors. Treatment Outcome

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  • (PMID = 18166957.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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28. Ali F, Brown A, Gottwald L, Thomas J: Basal cell carcinoma with matrical differentiation in a transplant patient: a case report and review of the literature. J Cutan Pathol; 2005 Jul;32(6):445-8
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  • BACKGROUND: Shadow cells, characterized by basaloid squamous cells with a distinct well-defined border and a central unstained area as a shadow of lost nuclei, are characteristic of pilomatricoma, a distinct neoplasm of hair matrix differentiation.
  • METHODS: A 58-year-old male cardiac transplant patient with a nodule on the dorsum of left hand was studied.
  • RESULTS: The H&E-stained sections of the hand lesion revealed multiple nodular masses of basaloid follicular germinative cells.
  • CONCLUSION: BCC with matrical differentiation is a distinct pathologic entity and a rare subtype of BCC featuring shadow and matrical cells, typically seen in pilomatricoma, a benign hair matrix neoplasm.
  • [MeSH-minor] Diagnosis, Differential. Hair Diseases / pathology. Hand / pathology. Humans. Male. Middle Aged. Pilomatrixoma / pathology

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  • (PMID = 15953381.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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29. Nakasu S, Fukami T, Jito J, Nozaki K: Recurrence and regrowth of benign meningiomas. Brain Tumor Pathol; 2009;26(2):69-72
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  • [Title] Recurrence and regrowth of benign meningiomas.
  • However, even benign meningiomas sometimes show relatively rapid growth and may recur after total removal.
  • We investigated 135 benign meningiomas, of which 120 were totally removed (Simpson's grade I-III).
  • On the other hand, the histological features of sheet-like growth, prominent nucleoli, and necrosis did not correlate with recurrence, because they were relatively rare in grade I tumors.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 19856217.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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30. Angeles-Angeles A: [Endocrine neoplasm of the stomach. Study of thirteen cases]. Gac Med Mex; 2005 May-Jun;141(3):207-13
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  • [Title] [Endocrine neoplasm of the stomach. Study of thirteen cases].
  • [Transliterated title] Tumores endocrinos del estómago. Análisis de 13 casos.
  • A Thirteen patients with primary endocrine neoplasm of the stomach were studied for 20 years.
  • These two forms of neoplasm showed important differences: those associated with atrophic gastritis had hypergastrinemia, all of the multiple small tumors confined to the corpus and fundus were well differentiated carcinoids associated with intestinal metaplasia and G cell hyperplasia in antrum and ECL cell hyperplasia in corpus and fundus.
  • Tumors were clinically benign, with an excellent prognosis.
  • All patients are currently alive with no evidence of neoplasm.
  • Two patients died as a consequence of the neoplasm; all of them were moderately differentiated and in none of the cases we found evidence of endocrine hyperplasia.
  • On the other hand, neuroendocrine carcinomas have a very poor prognosis with fatal outcome of patients.

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  • (PMID = 16025986.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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31. Lü BJ, Zhu J, Gao L, Xie L, Xu JY, Lai MD: [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):706-10
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  • RESULTS: The FNAC diagnostic failure (2); non-neoplastic lesions (12); benign neoplasm (82) and malignant neoplasm (17).
  • The three inaccurately diagnosed cases of FNAC are, as follows: reactive lymphoid hyperplasia of lymph node mistaken as non-Hodgkin lymphoma, mucoepidermoid carcinoma diagnosed as "scanty atypical cells present" and primary lymphoepithelial carcinoma mistaken as benign lymphoepithelial lesion.
  • On the basis of FNAC, 97.4% (110 /113) were correctly depicted as benign (95/96; 99.0%) or malignant (15/17; 88.2%).
  • Furthermore, 90.3% (102 /113) (specificity = 91.9%; 102/111) were accurately diagnosed, including 91.7% (88/96) benign lesions (specificity = 92.6% ; 88/95) and 82.4% (14/17) malignant tumors (specificity = 87.5%; 14/16).
  • CONCLUSIONS: FNAC is reliable in distinguishing benign and malignant salivary gland lesions.
  • On the other hand, due to the pitfalls in cytologic diagnosis of certain salivary gland tumors, tissue biopsy for histologic examination may be necessary.

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  • (PMID = 16536312.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Yano T, Shoji F, Baba H, Koga T, Shiraishi T, Orita H, Kohno H: Significance of the urinary 8-OHdG level as an oxidative stress marker in lung cancer patients. Lung Cancer; 2009 Jan;63(1):111-4
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  • The diagnosis included 81 primary lung cancers, 9 metastatic lung cancers and 10 benign lung diseases.
  • The urinary 8-OHdG level increased in the order of metastatic lung cancer, primary lung cancer and benign disease.
  • On the other hand, the capacity to repair oxidative DNA modifications might be impaired to some extent in cancer patients.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Oxygen / metabolism. Prospective Studies. Smoking

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  • (PMID = 18676055.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; G9481N71RO / Deoxyguanosine; S88TT14065 / Oxygen
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33. Abd El-Wahed MM: Expression and subcellular localization of maspin in human ovarian epithelial neoplasms: correlation with clinicopathologic features. J Egypt Natl Canc Inst; 2005 Sep;17(3):173-83
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  • They included 18 benign, 14 low malignant potential (LMP) and 46 malignant epithelial ovarian neoplasms, in addition to seven specimens from normal ovarian tissues as a control.
  • RESULTS: Immunohistochemical study of maspin expression using streptavidin biotin immunoperoxidase method revealed that, normal ovarian surface epithelium did not express maspin as well as benign serous and mucinous ovarian epithelial neoplasm.
  • However, all benign Brenner ovarian tumors were maspin positive.
  • On the other hand, 57.14% of LMP tumors showed weak maspin expression and 63% of malignant ovarian epithelial tumors showed maspin expression with 39.1% over expression.

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  • (PMID = 16799655.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen; 0 / SERPIN-B5; 0 / Serine Proteinase Inhibitors; 0 / Serpins
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34. Chiang ER, Chen TH: Multiple glomus tumors in gastrocnemius muscle: a case report. Arch Orthop Trauma Surg; 2008 Jan;128(1):29-31
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  • Glomus tumors are rare benign tumors that account 1-5% of soft tissue tumors of the hand.
  • [MeSH-major] Glomus Tumor / diagnosis. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17624538.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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35. Pérez de la Fuente T, Vega C, Gutierrez Palacios A, Sanchez Lorenzo J, Gonzalez Sarasua J: Glomangiosarcoma of the hypothenar eminence: a case report. Chir Main; 2005 Jun-Aug;24(3-4):199-202
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  • There are only two cases described on the hand before instead of the benign glomus tumor is usually located at this level.
  • Histochemically the glomangiosarcoma shows features that remind a benign glomus tumor, except for the malignant glomus tumor arising de novo.
  • This neoplasm is considered a low grade malignant tumor with tendency to local recurrence, though metastasis have been reported.
  • [MeSH-major] Glomus Tumor / pathology. Hand / surgery. Skin Neoplasms / pathology

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  • (PMID = 16121631.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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36. Maes L, Kalala JP, Cornelissen M, de Ridder L: Progression of astrocytomas and meningiomas: an evaluation in vitro. Cell Prolif; 2007 Feb;40(1):14-23
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  • By verifying the proliferation capacity, human telomerase reverse transcriptase (hTERT) expression and in vitro invasion, in a group of highly malignant glioblastomas, benign meningiomas and astrocytomas, at the initial stage of progression, we have analysed putative progression in vitro for proliferation and telomerase expression.
  • The group of benign meningiomas had a labelling index of 2.2 (SD = 2.7).
  • The group of benign meningiomas had a labelling index of 12.4 (SD = 19.2) for hTERT.
  • On the other hand, hTERT expression and cell proliferation are not linked directly to invasion in vitro.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Telomerase / analysis. Tumor Cells, Cultured

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  • (PMID = 17227292.001).
  • [ISSN] 0960-7722
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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37. Yamauchi N, Watanabe A, Hishinuma M, Ohashi K, Midorikawa Y, Morishita Y, Niki T, Shibahara J, Mori M, Makuuchi M, Hippo Y, Kodama T, Iwanari H, Aburatani H, Fukayama M: The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Mod Pathol; 2005 Dec;18(12):1591-8
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  • Then, we evaluated the feasibility of GPC3-immunohistochemistry in the pathological diagnosis of benign and malignant hepatocellular lesions by applying these monoclonal antibodies to formalin-fixed and paraffin-embedded specimens.
  • On the other hand, there was only weak and focal staining in low-grade (2/8) and high-grade dysplastic nodules (6/8).
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Hepatocellular / diagnosis. Heparan Sulfate Proteoglycans / metabolism. Liver Neoplasms / diagnosis

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  • (PMID = 15920546.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Glypicans; 0 / Heparan Sulfate Proteoglycans
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38. Neves AF, Araújo TG, Biase WK, Meola J, Alcântara TM, Freitas DG, Goulart LR: Combined analysis of multiple mRNA markers by RT-PCR assay for prostate cancer diagnosis. Clin Biochem; 2008 Oct;41(14-15):1191-8
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  • DESIGN AND METHODS: AR, SRD5A2, KLK2, PSMA, and PCA3 transcripts were analyzed by multiplex RT-PCR assay in 73 prostatic tissue samples from patients with prostate cancer (PCa) and benign hyperplasia (BPH).
  • AR, KLK2, PSMA, and PCA3 genes displayed increased transcriptional levels in the cancer specimens; on the other hand, SRD5A2 mRNA levels were higher in the BPH samples.
  • [MeSH-minor] 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / genetics. 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / metabolism. Aged. Aged, 80 and over. Antigens, Neoplasm / genetics. Antigens, Neoplasm / metabolism. Gene Expression Profiling. Genes, Neoplasm. Humans. Kallikreins / genetics. Kallikreins / metabolism. Male. Middle Aged. Odds Ratio. Prostate-Specific Antigen / genetics. Prostate-Specific Antigen / metabolism. Prostatic Hyperplasia / diagnosis. Prostatic Hyperplasia / enzymology. Prostatic Hyperplasia / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptors, Androgen / genetics. Receptors, Androgen / metabolism

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  • (PMID = 18640109.001).
  • [ISSN] 1873-2933
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AR protein, human; 0 / Antigens, Neoplasm; 0 / RNA, Messenger; 0 / Receptors, Androgen; 0 / prostate cancer antigen 3, human; EC 1.3.99.5 / 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; EC 3.4.21.- / Kallikreins; EC 3.4.21.77 / Prostate-Specific Antigen
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39. Puhaindran ME, Pratt J, Manoso MW, Healey JH, Mintz DN, Athanasian EA: Predictive value of magnetic resonance imaging in determining presence of residual disease after marginal excision of unsuspected soft tissue sarcomas of the hand. J Hand Surg Am; 2010 Sep;35(9):1479-84
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  • [Title] Predictive value of magnetic resonance imaging in determining presence of residual disease after marginal excision of unsuspected soft tissue sarcomas of the hand.
  • PURPOSE: Diagnosis of a soft tissue sarcoma of the hand is at times made only in retrospect after marginal excision of a presumed benign soft tissue mass.
  • METHODS: We retrospectively studied case records and imaging studies for all patients with soft tissue sarcomas of the hand evaluated and treated at our institution from 1996 to 2005.
  • Pathology examination after definitive wide resection or partial hand amputation showed that 15 patients had residual tumor, 9 gross and 6 microscopic.
  • The sensitivity of MRI in detecting residual soft tissue sarcoma of the hand was 60%, specificity was 78%, positive predictive value was 69%, and negative predictive value was 70%.
  • The sensitivity of MRI in detecting gross residual soft tissue sarcoma of the hand was 89%, specificity was 79%, positive predictive value was 62%, and negative predictive value was 95%.
  • CONCLUSIONS: Magnetic resonance imaging does not reliably detect residual gross or microscopic soft tissue sarcoma after marginal excision of unsuspected soft tissue sarcomas of the hand, with residual tumor not readily distinguished from postoperative change.
  • [MeSH-major] Hand / pathology. Magnetic Resonance Imaging / methods. Neoplasm, Residual / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Child. Cohort Studies. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Reoperation. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Surgical Procedures, Operative / methods. Young Adult

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  • [Copyright] Copyright 2010. Published by Elsevier Inc.
  • (PMID = 20807625.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Simonetti S, Mignogna C, La Mantia V, Lanza F, Insabato L: Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report. Tumori; 2009 Jan-Feb;95(1):101-3
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  • Intraosseous cavernomas are very rare benign lesions representing less than 1% of all skeletal tumors and most frequently observed in vertebrae and head and neck bones.
  • Solitary hemangiomas of the hand bones are exceptionally rare.
  • We report a case of this neoplasm in the distal epiphysis of the third metacarpal bone in a 68-year-old man, along with the clinicopathological findings.

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  • (PMID = 19366066.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Tissier F: Classification of adrenal cortical tumors: what limits for the pathological approach? Best Pract Res Clin Endocrinol Metab; 2010 Dec;24(6):877-85
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  • Most adrenocortical tumors are benign; adrenocortical carcinomas are rare but their prognosis is poor and their therapeutics are sparse.
  • In most adrenocortical tumors, the morphological approach in particular by Weiss system, brings sufficient elements to establish the differential diagnosis between a benign and a malignant tumor.
  • But some tumors of Weiss score of 2 or 3 can raise problems: are they benign, malignant or are they of uncertain malignant potential?
  • On the other hand, some Weiss criteria are difficult to evaluate as, for example, sinusoidal invasion.
  • [MeSH-minor] Adrenal Cortex / metabolism. Adrenal Cortex / pathology. Animals. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 21115156.001).
  • [ISSN] 1878-1594
  • [Journal-full-title] Best practice & research. Clinical endocrinology & metabolism
  • [ISO-abbreviation] Best Pract. Res. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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42. Lorenzoni PJ, Lange MC, Kay CS, Silvado CE, Scola RH, Werneck LC: [Fibrolipomatous hamartoma of the median nerve: case report]. Arq Neuropsiquiatr; 2005 Sep;63(3B):881-4
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  • [Transliterated title] Hamartoma fibrolipomatoso de nervo mediano: relato de caso.
  • Fibrolipomatous hamartoma is a rare benign neoplasm that in some cases is associated with macrodactylia.
  • We describe a 31-year-old man who had a tissue enlargement in the wrist, second and third fingers of the left hand since infancy.
  • At 23-years-old he began with continuous, progressive and high intensity pain that occurred more frequently at night, localized in the left hand.
  • Investigation with X-ray, ultrasonography, electrodiagnosis, magnetic resonance image of the left wrist and hand showed carpal tunnel syndrome with macrodactylia by fibrolipomatous hamartoma of the median nerve.

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  • (PMID = 16258677.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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43. Al-Shaham AA, Samher AA: Cemento-ossifying fibroma of the maxilla. J Plast Surg Hand Surg; 2010 Dec;44(6):318-21
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  • In 1992 The World Health Organization adopted a new classification that included these fibromas as benign osseous tumours.
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neoplasm Invasiveness / pathology. Neoplasm Staging. Risk Assessment. Surgical Procedures, Operative / methods. Time Factors. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 21446812.001).
  • [ISSN] 2000-6764
  • [Journal-full-title] Journal of plastic surgery and hand surgery
  • [ISO-abbreviation] J Plast Surg Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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44. Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R: A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation. Urology; 2005 Nov;66(5):1066-71
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  • RESULTS: In 18 patients, 42 nodes were sampled, of which 25 were benign and 17 were malignant.
  • On the other hand, the sensitivity of size criteria for detecting malignant nodes was 70.5%, the specificity was 68%, and the accuracy was 69%.
  • [MeSH-minor] Adult. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Nanostructures. Neoplasm Staging. Pilot Projects. Prospective Studies


45. Ankem MK, Hedican SP, Pareek G, Waterman BJ, Moon TD, Selvaggi SM, Nakada SY: Examination of laparoscopic retrieval bag washings for malignant cells after hand-assisted laparoscopic radical nephrectomy and intact specimen removal. Urology; 2006 Jul;68(1):50-2
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  • [Title] Examination of laparoscopic retrieval bag washings for malignant cells after hand-assisted laparoscopic radical nephrectomy and intact specimen removal.
  • OBJECTIVES: Port site metastases after hand-assisted laparoscopic radical nephrectomy have been described in the literature.
  • METHODS: We prospectively obtained washings from the LapSac retrieval bag after hand-assisted laparoscopic radical nephrectomy and intact specimen removal for renal cell carcinoma.
  • RESULTS: We performed 30 hand-assisted laparoscopic radical nephrectomies for suspected renal cell carcinoma with the above protocol.
  • One specimen was benign and one showed transitional cell carcinoma; these were excluded from the study.
  • [MeSH-major] Carcinoma, Renal Cell / surgery. Diagnostic Techniques, Urological. Kidney Neoplasms / surgery. Laparoscopy. Neoplasm Seeding. Nephrectomy

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  • (PMID = 16806416.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, Furukawa K, Mitsuhashi N, Takeuchi D, Takayashiki T, Suda K, Miyazaki M: Surgical strategy for mucin-producing bile duct tumor. J Hepatobiliary Pancreat Sci; 2010 May;17(3):236-40
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  • Because mucin produced by these tumors causes recurrent cholangitis and obstructive jaundice, surgical resection should be indicated even if these tumors are regarded as benign.
  • On the other hand, when precise diagnosis is completed preoperatively and the lesion is diagnosed as adenoma or carcinoma with invasion confined to the ductal wall and limited superficial spreading, limited resections preserving organ functions as much as possible can be considered as a choice among surgical procedures.
  • [MeSH-minor] Bile Ducts, Extrahepatic / metabolism. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Digestive System Surgical Procedures. Hepatectomy. Humans. Neoplasm Invasiveness. Pancreaticoduodenectomy. Prognosis

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  • (PMID = 19649559.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 20
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47. Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT: Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol; 2009 Oct;36 Suppl 1:60-5
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  • A perineurioma is a benign peripheral nerve sheath neoplasm thought to be derived from cells of the perineurium, the cellular sheathing of peripheral nerve fascicles.
  • In 2002, Huang and Sung described a 16-year-old boy with one sclerosing perineurioma on each hand.
  • [MeSH-minor] Adult. Arm / pathology. Arm / surgery. Female. Hand / pathology. Hand / surgery. Humans. Immunohistochemistry

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  • (PMID = 19187114.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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48. Hatori M, Watanabe M, Kotake H, Kokubun S: Chondrosarcoma of the ring finger: a case report and review of the literature. Tohoku J Exp Med; 2006 Mar;208(3):275-81
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  • Enchondromas are the most common benign cartilaginous bone tumors arising in the medullary cavity of the small bones of the hand.
  • In conclusion, details of radiological as well as pathological findings are essential for differential diagnosis between benign enchondroma and chondrosarcoma in the hand.
  • Chondrosarcoma of the hand requires a prompt and more radical treatment than enchondroma.
  • [MeSH-minor] Aged, 80 and over. Chondroma / diagnosis. Diagnosis, Differential. Disease-Free Survival. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16498237.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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49. Attasaranya S, Pais S, LeBlanc J, McHenry L, Sherman S, DeWitt JM: Endoscopic ultrasound-guided fine needle aspiration and cyst fluid analysis for pancreatic cysts. JOP; 2007;8(5):553-63
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  • CONTEXT: Endoscopic ultrasound (EUS) with EUS-guided fine needle aspiration (EUS-FNA) has been increasingly utilized to differentiate malignant/pre-malignant pancreatic cysts from those that are benign or have low malignant potential.
  • There were more women in the mucinous cystic neoplasm group compared to the non-mucinous cystic neoplasm group (88% vs. 47%; P=0.011) but the two groups were otherwise similar.
  • Median cyst fluid CEA for the mucinous cystic neoplasm group (277 ng/mL; n=14) was significantly higher (P=0.002) than the non-mucinous cystic neoplasm group (1.5 ng/mL; n=21).
  • Cyst fluid CEA greater than 800 ng/mL had a sensitivity of 42.9% (95% CI: 21.3-67.4%) and specificity of 95.2% (95% CI: 75.6-99.9%) for the diagnosis of mucinous cystic neoplasm.
  • On the other hand, a cyst fluid CEA greater than a best cut-off ranging from 3.5 to 8.5 ng/mL had a sensitivity of 92.9% (95% CI: 66.5-100%), a specificity of 66.7% (14/21; 95% CI: 45.2-83.0%), and an accuracy of 81.1% with a frequency of cases correctly identified of 77.1% (95% CI: 60.7-88.2%).

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  • (PMID = 17873459.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Mucins
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50. Pham TT, Selim MA, Burchette JL Jr, Madden J, Turner J, Herman C: CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol; 2006 Feb;33(2):123-8
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  • BACKGROUND: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC).
  • On the other hand, expression of CD10 by basaloid cells was identified in 20 (87%) cases of BCC.

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  • (PMID = 16420307.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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51. Slesarenko YA, Sampson SP, Gould ES, Dagum AB: Recurrent enchondroma protuberans: a case report. J Hand Surg Am; 2005 Nov;30(6):1318-21
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  • Enchondroma protuberans is a rare benign tumor.
  • We present a case of late recurrence of a previously reported enchondroma protuberans in the hand.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroma / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16344196.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Fnini S, Labsaili N, Messoudi A, Largab A: [Giant cell tumor of the thumb proximal phalanx: resection-iliac graft and double arthrodesis]. Chir Main; 2008 Feb;27(1):54-7
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  • [Transliterated title] Tumeur à cellules géantes de la phalange proximale du pouce: résection-autogreffe iliaque et arthrodèse bipolaire.
  • Giant cell tumours (GCT) of bone are frequent, with variable behaviour, high risk of recurrence and an often benign histological appearance.
  • Their location in the hand is uncommon, and there are few publications on the subject.
  • [MeSH-minor] Arthrodesis. Biopsy. Bone Nails. Bone Transplantation. Finger Joint. Follow-Up Studies. Fracture Fixation, Internal / instrumentation. Fractures, Spontaneous / etiology. Fractures, Spontaneous / surgery. Humans. Male. Metacarpophalangeal Joint. Middle Aged. Neoplasm Staging. Patient Satisfaction. Time Factors. Treatment Outcome

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  • (PMID = 18248835.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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53. Kondo T, Tanaka Y: Malignant pilomatricoma in the parietal area. Pathol Oncol Res; 2006;12(4):251-3
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  • Malignant pilomatricoma, a locally aggressive counterpart of benign pilomatricoma, is also referred to as pilomatrix carcinoma.
  • Most cases are excised as benign tumors; however, when the excision is incomplete local recurrence is likely, and distant metastases have also been reported.
  • Because of the rarity of malignant pilomatricoma, no welldefined standards in the surgical management of this neoplasm have been established.

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54. Haque AU, Moatasim A: Giant cell tumor of bone: a neoplasm or a reactive condition? Int J Clin Exp Pathol; 2008;1(6):489-501
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  • [Title] Giant cell tumor of bone: a neoplasm or a reactive condition?
  • Giant cell tumor of bone (GCTB) is a benign but locally aggressive bone tumor of young adults.
  • On the other hand, dilatation of the thin-walled blood vessels results in formation of ABCs.

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  • (PMID = 18787633.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480584
  • [Keywords] NOTNLM ; Giant cell tumor / aneurysmal bone cyst / bone / bone matrix / hemorrhage / osteoclast / osteoclastoma / telomerase
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55. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-major] Hand / pathology. Liposarcoma / pathology

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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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56. Zeng Y, Yang WT, Zhang GH, Zhu XZ: [Study of HOXA5 gene expression in breast carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2005 Sep;34(9):569-74
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  • METHODS: TaqMan real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was applied on 60 cases of primary breast carcinoma and 24 cases of benign mammary lesions in order to detect mRNA expression of HOXA5 gene.
  • (1) The relative expression level of HOXA5 mRNA ranged from 0.73 to 193.07 (average = 20.85) in primary breast carcinoma, in contrast to 5.42 to 81.91 (average = 30.94) in benign mammary lesions.
  • Compared with benign mammary lesions, a significant reduction in expression of HOXA5 mRNA was noted in primary breast carcinoma (P < 0.01). (2) There was a decreased or completely diminished HOXA5 protein expression in breast carcinoma. (3) HOXA5 mRNA expression was significantly lower in lymph node-positive cases, when compared with that in lymph node-negative cases (P < 0.05).
  • On the other hand, moderately or strongly positive HOXA5 staining was noted in lymph node-negative cases. (4) Neither mRNA nor protein expression of HOXA5 gene correlated with clinicopathologic parameters such as age of patients, size of tumor, clinical stage, pathologic subtype or histologic grade (P > 0.05).
  • [MeSH-minor] Adult. Aged. Breast / metabolism. Breast / pathology. Female. Gene Expression Regulation, Neoplastic. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Staging. Papilloma, Intraductal / metabolism. Papilloma, Intraductal / pathology. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 16468307.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / HOXA5 protein, human; 0 / Homeodomain Proteins; 0 / RNA, Messenger
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57. Rammeh-Rommani S, Mokni M, Stita W, Trabelsi A, Hamissa S, Sriha B, Tahar-Yacoubi M, Korbi S: [Uterine smooth muscle tumors: retrospective epidemiological and pathological study of 2760 cases]. J Gynecol Obstet Biol Reprod (Paris); 2005 Oct;34(6):568-71
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  • [Transliterated title] Les tumeurs musculaires lisses de l'utérus: étude épidémiologique et anatomo-pathologique rétrospective de 2760 cas.
  • Most of them are benign.
  • On the other hand 87.5% of leiomyosarcomas had unique nodules (p=0,04).
  • [MeSH-minor] Female. Humans. Leiomyoma / epidemiology. Leiomyoma / pathology. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 16208199.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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58. Avshalumov K, Williford P, Sangueza OP, Goldenberg G: Atypical fibroxanthoma presenting in a patient with stage III mycosis fungoides. J Dermatolog Treat; 2008;19(2):118-20
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  • We report a 77-year-old female who was referred for Mohs micrographic surgery (MMS) of an AFX on the right hand.
  • The pathologic specimen revealed a relatively well-circumscribed neoplasm in the upper dermis composed of atypical spindle cells with pleomorphism, hyperchromatic nuclei, and brisk mitotic activity.
  • One year after the initial MMS, our patient developed another tumor on the right hand, which measured 4x6 mm.
  • This neoplasm underwent a fusiform excision with clear margins.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Mycosis Fungoides / pathology. Skin Neoplasms / pathology

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  • (PMID = 18484429.001).
  • [ISSN] 0954-6634
  • [Journal-full-title] The Journal of dermatological treatment
  • [ISO-abbreviation] J Dermatolog Treat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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59. Travaini LL, Petralia G, Trifirò G, Ravasi L, Galetta D, Carbone G, Falcini F, Spaggiari L, Bellomi M, Paganelli G: [18F]FDG positron emission tomography/computed tomography and multidetector computed tomography roles in thymic lesion treatment planning. Lung Cancer; 2008 Sep;61(3):362-8
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  • Our retrospective study aims to assess multidetector computed tomography and 2-[(18)F]fluoro-2-deoxyglucose positron emission tomography/computed tomography ([(18)F]FDG-PET/CT) capacity to distinguish benign from malignant thymic lesions.
  • RESULTS: In the group of benign lesions MDCT correctly identified well-defined margins of masses in 8 out of 8 patients whereas [(18)F]FDG-PET/CT was negative in 7 out of 8 patients.
  • On the other hand [(18)F]FDG-PET/CT showed increased radiotracer uptake in 12/12 patients.
  • However, they are two non-invasive complementary techniques which can be used to differentiate benign from high-risk malignant thymic lesions.
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Retrospective Studies

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  • (PMID = 18358558.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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60. A J, Kc BR, Basnet SB, Panth R, Shrestha RL, Chand P, Thapa BB: Adamantinoma of tibial shaft. JNMA J Nepal Med Assoc; 2009 Oct-Dec;48(176):331-4
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  • Adamantinoma is an extremely rare primary bony neoplasm.
  • On the other hand adamantinoma mimics many benign conditions, so it is doubly important to establish correct tissue diagnosis to avoid radical surgery with morbidities.

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  • (PMID = 21105562.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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66. Tanaka M, Kobayashi K, Mizumoto K, Yamaguchi K: Clinical aspects of intraductal papillary mucinous neoplasm of the pancreas. J Gastroenterol; 2005 Jul;40(7):669-75
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  • [Title] Clinical aspects of intraductal papillary mucinous neoplasm of the pancreas.
  • Intraductal papillary mucinous neoplasm (IPMN) is a spectrum of neoplasia in the pancreatic duct epithelium characterized by cystic dilation of the main and/or branch pancreatic duct.
  • Most branch duct IPMNs are benign, whereas the other two types are often malignant.
  • The prognosis is favorable after complete resection of benign and noninvasive malignant IPMNs.
  • On the other hand, asymptomatic branch duct IPMNs without mural nodules can be observed without resection for a considerably long time.
  • [MeSH-minor] Age Distribution. Aged. Aged, 80 and over. Cholangiopancreatography, Endoscopic Retrograde / methods. Endosonography / methods. Female. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Neoplasm Staging. Prognosis. Risk Assessment. Sex Distribution. Survival Analysis

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  • (PMID = 16082582.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 58
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67. Teefey SA, Dahiya N, Middleton WD, Gelberman RH, Boyer MI: Ganglia of the hand and wrist: a sonographic analysis. AJR Am J Roentgenol; 2008 Sep;191(3):716-20
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  • [Title] Ganglia of the hand and wrist: a sonographic analysis.
  • MATERIALS AND METHODS: A computer search of sonography and pathology reports for hand and wrist ganglia was performed.
  • Solid-appearing ganglia, although unusual, may mimic a benign neoplasm or synovitis.
  • [MeSH-major] Ganglion Cysts / ultrasonography. Hand / ultrasonography. Ultrasonography / methods. Wrist / ultrasonography

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  • (PMID = 18716098.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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68. Chamberlain AM, Anderson KL, Hoch B, Trumble TE, Weisstein JS: Benign parosteal osteochondromatous proliferation of the hand originally diagnosed as osteochondroma: a report of two cases and review. Hand (N Y); 2010 Mar;5(1):106-10
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  • [Title] Benign parosteal osteochondromatous proliferation of the hand originally diagnosed as osteochondroma: a report of two cases and review.
  • Bizarre parosteal osteochondromatous proliferation (BPOP) is a rare cartilaginous neoplasm that often presents in the long bones of the hands and feet.
  • BPOP is a benign but locally aggressive fibro-osseous mass that has striking clinical, radiographic, and histologic similarities with osteochondroma.

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  • (PMID = 19669236.001).
  • [ISSN] 1558-9455
  • [Journal-full-title] Hand (New York, N.Y.)
  • [ISO-abbreviation] Hand (N Y)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2820629
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69. Wada I, Shimizu N, Seto Y: [Treatment of neuroendocrine tumors of the digestive tract]. Gan To Kagaku Ryoho; 2009 Oct;36(10):1606-10
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  • Neuroendocrine tumors of the digestive tract are relatively rare and comprise benign and malignant tumors.
  • Endoscopic submucosal dissection(ESD)or local resection can be performed in low grade and early stage tumors; on the other hand, curative resection with lymph node dissection is recommended for neuroendocrine carcinoma.
  • [MeSH-minor] Combined Modality Therapy. Humans. Neoplasm Metastasis / drug therapy. Neoplasm Metastasis / pathology. Neoplasm Staging. Prognosis

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  • (PMID = 19838017.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antinematodal Agents
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70. Itoi T, Neuhaus H, Chen YK: Diagnostic value of image-enhanced video cholangiopancreatoscopy. Gastrointest Endosc Clin N Am; 2009 Oct;19(4):557-66
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  • Pilot studies suggest that chromoendocholangioscopy using methylene blue or cholangioscopy using AFI can distinguish benign from malignant bile duct lesions.
  • On the other hand, the NBI system enhances the imaging of certain features such as mucosal structures and microvessels in pancreatobiliary lesions.
  • In patients with main-duct-type intraductal papillary mucinous neoplasm, peroral pancreatoscopy can be used to determine extent of tumor involvement.
  • Although many technical hurdles still need to be overcome, image-enhanced cholangiopancratoscopy appears to be a promising modality to improve diagnostic accuracy of pancreatobiliary diseases, particularly in distinguishing benign from malignant lesions.

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  • (PMID = 19917461.001).
  • [ISSN] 1558-1950
  • [Journal-full-title] Gastrointestinal endoscopy clinics of North America
  • [ISO-abbreviation] Gastrointest. Endosc. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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71. Yamaoka H, Ohtsu K, Sueda T, Yokoyama T, Hiyama E: Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors. Oncol Rep; 2006 Mar;15(3):551-6
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  • Hepatoblastoma (HBL), a major childhood malignant neoplasm, represents the most frequent malignant liver tumor in childhood.
  • We investigated the genetic alterations of the CTNNB1 coding beta-catenin protein and expression of several genes downstream of Wnt signals in 4 benign and 17 malignant pediatric liver tumors (PLTs) consisting of 15 HBL, 1 hepatocellular carcinoma, and 1 hepatic immature sarcoma.
  • On the other hand, the expression of cyclin D1, a gene downstream of beta-catenin, might play a role in tumor progression.
  • [MeSH-minor] Cadherins / analysis. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / metabolism. Child. Child, Preschool. Cyclin D1 / analysis. DNA Mutational Analysis. DNA, Neoplasm / chemistry. DNA, Neoplasm / genetics. Female. Hepatoblastoma / diagnosis. Hepatoblastoma / genetics. Hepatoblastoma / metabolism. Humans. Immunohistochemistry. Infant. Male. Prognosis


72. Bertin M, Angriman I, Scarpa M, Mencarelli R, Ranzato R, Ruffolo C, Polese L, Iacobone M, D'Amico DF: Prognosis of gastrointestinal stromal tumors. Hepatogastroenterology; 2007 Jan-Feb;54(73):124-8
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  • Mitotic index (MI) and size neoplasm were the main pathological criteria for malignity.
  • On the other hand, criteria of benign behavior did not completely predict the long-term clinical outcome.

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  • (PMID = 17419245.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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73. Hua K, Feng W, Cao Q, Zhou X, Lu X, Feng Y: Estrogen and progestin regulate metastasis through the PI3K/AKT pathway in human ovarian cancer. Int J Oncol; 2008 Nov;33(5):959-67
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  • We investigated nm23-H1, AKT and pAKT expression by using immunohistochemical staining in ovarian clear cell adenocarcinoma, ovarian benign, borderline and malignant serous tumors and analyzed their relationship with prognostic factors.
  • On the other hand, it reinforced the effect of progestin.
  • [MeSH-minor] Cell Line, Tumor. Cell Movement. Dose-Response Relationship, Drug. Female. Humans. Medroxyprogesterone Acetate / pharmacology. Middle Aged. NM23 Nucleoside Diphosphate Kinases / metabolism. Neoplasm Metastasis. Neoplasm Staging. Phosphorylation. Prognosis. Protein Kinase Inhibitors / pharmacology. RNA Interference. RNA, Small Interfering / metabolism. Signal Transduction / drug effects. Time Factors

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  • (PMID = 18949358.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Estrogens; 0 / NM23 Nucleoside Diphosphate Kinases; 0 / Progestins; 0 / Protein Kinase Inhibitors; 0 / RNA, Small Interfering; C2QI4IOI2G / Medroxyprogesterone Acetate; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.4.6 / NME1 protein, human
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74. Kawano K, Ono K, Yada N, Takahashi Y, Kashima K, Yokoyama S, Yanagisawa S: Malignant calcifying epithelial odontogenic tumor of the mandible: report of a case with pulmonary metastasis showing remarkable response to platinum derivatives. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jul;104(1):76-81
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  • The primary tumor revealed typical histological features of benign CEOT showing sheets of polyhedral epithelial cells associated with abundant eosinophilic amyloid-like materials.
  • On the other hand, the locally recurrent tumors had malignant features, such as increased nuclear pleomorphism with frequent mitotic figures and vascular invasion of tumor cells, as well as increased proliferative activity assessed by immunostaining for Ki-67.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Lung Neoplasms / drug therapy. Mandibular Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy. Odontogenic Cyst, Calcifying / drug therapy

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  • (PMID = 17577547.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; Q20Q21Q62J / Cisplatin
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75. Gaeta M, Mazziotti S, Minutoli F, Genitori A, Toscano A, Rodolico C, Blandino A: MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm. Skeletal Radiol; 2009 Jun;38(6):571-8
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  • [Title] MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm.
  • Dynamic enhancement pattern corresponded to the type usually seen in benign soft tissue lesions.

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  • (PMID = 19255757.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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76. Maes L, Kalala JP, Cornelissen M, De Ridder L: PCNA, Ki-67 and hTERT in residual benign meningiomas. In Vivo; 2006 Mar-Apr;20(2):271-5
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  • [Title] PCNA, Ki-67 and hTERT in residual benign meningiomas.
  • BACKGROUND: Relapse in individual patients after incomplete/residual removal of meningiomas cannot be predicted by histology alone as re-growth occurs even in histologically benign meningiomas.
  • On the other hand, a statistical difference between the two groups of meningiomas was found for hTERT; however, it is no absolute predictor for relapse at the individual patient level.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Cell Proliferation. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual / metabolism. Neoplasm, Residual / pathology

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  • (PMID = 16634530.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; EC 2.7.7.49 / Telomerase
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77. Nazerani S, Motamedi MH, Keramati MR: Diagnosis and management of glomus tumors of the hand. Tech Hand Up Extrem Surg; 2010 Mar;14(1):8-13
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  • [Title] Diagnosis and management of glomus tumors of the hand.
  • AIM AND BACKGROUND: Glomus tumors are hamartomas that account for 1% to 5% of all soft tissue tumors of the hand.
  • These tumors are usually benign.
  • MATERIALS AND METHODS: Eight patients who were diagnosed with glomus tumor of the hand were treated.
  • CONCLUSIONS: Glomus tumor is a rare disease; we encountered only 0.26% cases in our patients (3014 patients referring for hand surgery) during a 10-year period.
  • [MeSH-major] Glomus Tumor / diagnosis. Glomus Tumor / surgery. Hand. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Nails, Malformed / etiology. Neoplasm Recurrence, Local. Postoperative Complications

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  • (PMID = 20216046.001).
  • [ISSN] 1531-6572
  • [Journal-full-title] Techniques in hand & upper extremity surgery
  • [ISO-abbreviation] Tech Hand Up Extrem Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Korzeniewska M, Kołomecki K, Stepień H, Naze M, Stepień T, Kuzdak K: [Assessment of pro- and antiangiogenic factors blood serum concentrations in patients with hormonal inactive adrenal tumors]. Endokrynol Pol; 2005 Jan-Feb;56(1):39-44
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  • On the other hand the mean VEGF (334.2 pg/ml) concentration in patients with benign adrenocortical adenoma wasn't significant different than in control group (p>0.05) but mean sVEGFR-1 (21.7 pg/ml) and sVEGFR-2 (7106.4 pg/ml) concentrations were significantly lower than in the control (p<0.05).
  • [MeSH-minor] Adrenocortical Adenoma / blood. Adrenocortical Adenoma / pathology. Adrenocortical Carcinoma / blood. Adrenocortical Carcinoma / pathology. Adrenocortical Carcinoma / secondary. Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Vascular Endothelial Growth Factor Receptor-1 / blood. Vascular Endothelial Growth Factor Receptor-2 / blood

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  • (PMID = 16335673.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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79. Ergun T, Lakadamyali H, Derincek A, Tarhan NC, Ozturk A: Magnetic resonance imaging in the visualization of benign tumors and tumor-like lesions of hand and wrist. Curr Probl Diagn Radiol; 2010 Jan-Feb;39(1):1-16
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  • [Title] Magnetic resonance imaging in the visualization of benign tumors and tumor-like lesions of hand and wrist.
  • The differential diagnosis of benign tumors and tumor-like lesions of the hand and wrist region is important with regard to choosing the therapy (medical versus surgical), or to decide to just follow-up the lesion.
  • However, diagnostic confusion is not uncommon as there are numerous lesions affecting the hand and wrist region.
  • This pictorial essay offers a practical radiological approach to benign tumors and tumor-like lesions of the hand and wrist region based on most frequently observed MRI findings.
  • [MeSH-major] Hand / pathology. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis. Wrist / pathology
  • [MeSH-minor] Adult. Aged. Arteriovenous Malformations / diagnosis. Contrast Media. Diagnosis, Differential. Female. Giant Cell Tumors / diagnosis. Humans. Image Enhancement / methods. Lipoma / diagnosis. Male. Middle Aged. Neoplasm Staging. Young Adult

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  • (PMID = 19931109.001).
  • [ISSN] 1535-6302
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 49
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80. Sakurai H, Kaji M, Mukai K, Suemasu K: Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case. Surg Today; 2010;40(2):146-9
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  • [Title] Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case.
  • An ectopic hamartomatous thymoma is an extremely rare benign neoplasm that commonly occurs in the lower neck region.

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  • (PMID = 20107954.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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81. Shigematsu K, Kobata Y, Yajima H, Kawamura K, Maegawa N, Takakura Y: Giant-cell tumors of the carpus. J Hand Surg Am; 2006 Sep;31(7):1214-9
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  • Giant cell tumor (GCT) of bone is a rare, benign tumor with some aggressive characteristics such as a high recurrence rate.
  • [MeSH-minor] Amputation. Bone Transplantation. Cryosurgery. Curettage. Humans. Neoplasm Recurrence, Local

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  • (PMID = 16945730.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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82. Taleb C, Gouzou S, Mantovani G, Liverneaux P: Treatment of benign bone tumours of the hand using osteoscopy. Chir Main; 2010 Apr;29(2):78-81
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  • [Title] Treatment of benign bone tumours of the hand using osteoscopy.
  • Curettage and bone grafting are used traditionally to treat benign bone tumours of the hand.
  • This is a report on three benign metacarpal bone tumours treated with three different endoscopic approaches: multiportal, extended uniportal and oblique uniportal.
  • All things considered, the oblique osteoscopic uniportal approach seems to be the best option for the management of benign bone tumours of the hand.
  • [MeSH-minor] Adult. Bone Cements / therapeutic use. Bone Diseases, Developmental / surgery. Chondroma / surgery. Clinical Protocols. Female. Fluoroscopy. Humans. Male. Neoplasm Recurrence, Local / prevention & control. Treatment Outcome

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20153235.001).
  • [ISSN] 1769-6666
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Cements
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83. Yanagawa T, Watanabe H, Shinozaki T, Takagishi K: Curettage of benign bone tumors without grafts gives sufficient bone strength. Acta Orthop; 2009 Feb;80(1):9-13
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  • [Title] Curettage of benign bone tumors without grafts gives sufficient bone strength.
  • We report the outcome in patients with benign bone tumors that were treated with curettage but no filling.
  • PATIENTS AND METHODS: We retrospectively studied 78 patients (mean age at the time of operation was 27 (6-73) years, 44 men) who had had a benign bone tumor curetted with no filling of the defect.
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Remodeling / physiology. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19234882.001).
  • [ISSN] 1745-3682
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Other-IDs] NLM/ PMC2823236
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84. Puhaindran ME, Healey JH, Athanasian EA: Single ray amputation for tumors of the hand. Clin Orthop Relat Res; 2010 May;468(5):1390-5
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  • [Title] Single ray amputation for tumors of the hand.
  • Single ray amputation after hand trauma or infection can result in good aesthetic and functional outcomes.
  • The role of this procedure in the management of aggressive benign or malignant hand tumors has been described only in case reports and small case series.
  • The other was treated with radiotherapy alone, as local tumor control would have required a hand amputation.
  • Our study suggests single ray amputation for hand tumors has a low local recurrence rate and high functional scores.
  • [MeSH-major] Amputation / methods. Bone Neoplasms / surgery. Hand / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 19655212.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853661
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85. Czernobilsky B: Uterine tumors resembling ovarian sex cord tumors: an update. Int J Gynecol Pathol; 2008 Apr;27(2):229-35
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  • In the former, the sex cord component constitutes a minor portion of an endometrial stromal neoplasm, whereas in the latter, it is the predominant or exclusive component of a uterine wall lesion composed of a variety of mesenchymal elements.
  • In group 1 tumors, the prognosis depends on the type, grade, and stage of the underlying stromal neoplasm.
  • Group 2 tumors seemed to be benign, although because of the occasional recurrence of these tumors, they should be considered of low-grade malignant potential.
  • Endometrial stromal tumors with sex cord-like elements, on the other hand, usually express only 1 sex cord marker, mostly calretinin.

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  • (PMID = 18317219.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 40
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86. Kawamura K, Yajima H, Morishita T, Honoki K, Takakura Y: Plexiform schwannoma of the ulnar nerve. Scand J Plast Reconstr Surg Hand Surg; 2005;39(2):120-2
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  • Plexiform schwannoma is a rare benign neurogenic tumour; we report a case that arose in the ulnar nerve of a 59-year-old woman.
  • Exploration showed a continuous multinodular tumour that involved the ulnar nerve from the hand to the upper arm; the length of the tumour was 35 cm.

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  • (PMID = 16019742.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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87. Satpathy A, Moss C, Raafat F, Slator R: Spontaneous regression of a rare tumour in a child: angiolymphoid hyperplasia with eosinophilia of the hand: case report and review of the literature. Br J Plast Surg; 2005 Sep;58(6):865-8
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  • [Title] Spontaneous regression of a rare tumour in a child: angiolymphoid hyperplasia with eosinophilia of the hand: case report and review of the literature.
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign, idiopathic vasculoproliferative condition manifested by multiple or solitary subcutaneous nodules, usually in the head and neck region of young adults.
  • We report an 11-year-old girl with histologically confirmed ALHE on the dorsum of her left hand, which underwent complete spontaneous regression within 10 weeks.
  • Angiolymphoid hyperplasia is a benign disease and it is important to recognise this condition so that early superficial lesions can be observed for 3-6 months pending spontaneous regression.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Hand. Neoplasm Regression, Spontaneous

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  • (PMID = 16086996.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 30
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88. Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA: Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J; 2006;26:69-76
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  • Giant cell tumor is an aggressive benign neoplasm of bone.

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  • (PMID = 16789453.001).
  • [ISSN] 1541-5457
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
  • [Other-IDs] NLM/ PMC1888590
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89. Torosyan Y, Dobi A, Naga S, Mezhevaya K, Glasman M, Norris C, Jiang G, Mueller G, Pollard H, Srivastava M: Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription. Cancer Res; 2006 Oct 1;66(19):9609-16
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  • On the other hand, wild-type p53 restored 5-LOX expression in DU145 to levels comparable to benign prostate epithelial cells.
  • [MeSH-major] Adenocarcinoma / pathology. Annexin A7 / physiology. Arachidonate 15-Lipoxygenase / biosynthesis. Arachidonate 5-Lipoxygenase / biosynthesis. Arachidonic Acids / pharmacology. Neoplasm Proteins / physiology. Prostatic Neoplasms / pathology. Tumor Suppressor Protein p53 / physiology

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  • (PMID = 17018618.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A7; 0 / Arachidonic Acids; 0 / DNA-Binding Proteins; 0 / Neoplasm Proteins; 0 / Recombinant Fusion Proteins; 0 / Tumor Suppressor Protein p53; 207137-56-2 / Interleukin-4; 7S5I7G3JQL / Dexamethasone; EC 1.13.11.33 / ALOX15B protein, human; EC 1.13.11.33 / Arachidonate 15-Lipoxygenase; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
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90. Kosmidis C, Efthimiadis C, Anthimidis G, Karayannopoulou G, Grigoriou M, Vassiliadou K, Berovali E, Fachantidis P, Fahantidis E: Kaposi's sarcoma of the hand mimicking squamous cell carcinoma in a woman with no evidence of HIV infection: a case report. J Med Case Rep; 2008;2:213
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  • [Title] Kaposi's sarcoma of the hand mimicking squamous cell carcinoma in a woman with no evidence of HIV infection: a case report.
  • INTRODUCTION: Kaposi's sarcoma is a vascular neoplasm mainly affecting the skin of the lower extremities.
  • Although it is the most common neoplasm affecting patients with AIDS, sporadic cases in HIV-negative people have been reported.
  • It is a lesion mainly affecting men and its clinical presentation presents a challenge, as it can resemble other benign or malignant skin lesions.
  • The patient had a 6-month history of a slowly progressing pigmented lesion on the dorsum of her left hand.

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  • (PMID = 18565232.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2442120
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91. Zahid M, Asif N, Sabir AB, Siddiqui YS, Julfiqar M: Metachronous multicentric giant cell tumour of the upper extremity in a skeletally immature girl : A rare presentation. Acta Orthop Belg; 2010 Oct;76(5):694-8
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  • Giant Cell tumour (GCT) or Osteoclastoma is a benign locally aggressive tumour with a tendency for local recurrence.
  • We report a young girl presenting with metachronous multicentric recurrent benign GCT, with the lesions involving the ipsilateral right hand and distal humerus.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Hand Bones. Humerus. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Neoplasm Recurrence, Local

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  • (PMID = 21138229.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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92. Tsai HT, Tsai YM, Yang SF, Wu KY, Chuang HY, Wu TN, Ho CK, Lin CC, Kuo YS, Wu MT: Lifetime cigarette smoke and second-hand smoke and cervical intraepithelial neoplasm--a community-based case-control study. Gynecol Oncol; 2007 Apr;105(1):181-8
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  • [Title] Lifetime cigarette smoke and second-hand smoke and cervical intraepithelial neoplasm--a community-based case-control study.
  • BACKGROUND: Both active cigarette smoking and human papillomavirus (HPV) infection are known risk factors for cervical intraepithelial neoplasm (CIN).
  • The association between second-hand smoke (SHS) and CIN has not been conclusively determined.
  • A total of 171 subjects with either their first case of inflammation (benign epithelial lesion) or > or = CIN1 by biopsy confirmation were assigned to a case group; 513 normal subjects with negative findings by Pap smears or biopsies were assigned to a control group.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / epidemiology. Smoking / adverse effects. Tobacco Smoke Pollution / adverse effects. Uterine Cervical Neoplasms / epidemiology


93. Leuschner I: [Lipofibromatosis in a 6-year-old girl: a case report]. Pathologe; 2010 Mar;31(2):150-2
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  • Lipofibromatosis is a benign disease but recurrences are not unusual.
  • [MeSH-minor] Adipose Tissue / pathology. Child. Diagnosis, Differential. Female. Hand / pathology. Humans. Neoplasm Invasiveness

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  • (PMID = 20076960.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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94. Melillo RM, Santoro M, Vecchio G: Differential diagnosis of thyroid nodules using fine-needle aspiration cytology and oncogene mutation screening: are we ready? F1000 Med Rep; 2010;2:62
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  • Thyroid nodules are a very common clinical finding, and although the majority of them are benign, thyroid carcinoma accounts for about 5-15% of nodules.
  • Although in most cases this examination clearly distinguishes benign from malignant lesions, some fine-needle aspiration (FNA) samples fall into undetermined thyroid cytology categories, which according to the most recent classification of thyroid FNAC consist of 'suspicious for malignancy', 'suspicious for follicular or Hurtle cell neoplasm', and 'follicular lesion of undetermined significance/atypia of undetermined significance'.
  • On the other hand, patients with 'atypia of undetermined significance' undergo repeated FNAs, and patients with 'suspicious for follicular or Hurtle cell neoplasm' are subjected to diagnostic lobectomy and subsequently, in the case of histological diagnosis of carcinoma, total thyroidectomy.

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  • (PMID = 21170417.001).
  • [ISSN] 1757-5931
  • [Journal-full-title] F1000 medicine reports
  • [ISO-abbreviation] F1000 Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2994260
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95. Liu DH, Wang XM, Zhang LJ, Dai SW, Liu LY, Liu JF, Wu SS, Yang SY, Fu S, Xiao XY, He DC: Serum amyloid A protein: a potential biomarker correlated with clinical stage of lung cancer. Biomed Environ Sci; 2007 Feb;20(1):33-40
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  • On the other hand, 11.6 kDa protein was also increased in 50% benign diseases of lung and 13% of other cancer controls.
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / pathology. Adult. Aged. Carcinoma, Small Cell / blood. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / blood. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Neoplasm Staging. Peptides / blood. Protein Array Analysis

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  • (PMID = 17458139.001).
  • [ISSN] 0895-3988
  • [Journal-full-title] Biomedical and environmental sciences : BES
  • [ISO-abbreviation] Biomed. Environ. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptides; 0 / Serum Amyloid A Protein
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96. Mahfouz S, Aziz AA, Gabal SM, el-Sheikh S: Immunohistochemical study of CD99 and EMA expression in ependymomas. Medscape J Med; 2008;10(2):41
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  • Tumors of the central nervous system (CNS) represent a unique, heterogeneous population of neoplasms and include both benign and malignant tumors.
  • EMA expression and pattern of distribution, on the other hand, cannot be employed to determine the type of variant or the degree of tumor aggressiveness, and hence cannot predict the behavior of ependymal neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Gene Expression Profiling. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Proteins / analysis. Sensitivity and Specificity

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  • (PMID = 18382710.001).
  • [ISSN] 1934-1997
  • [Journal-full-title] Medscape journal of medicine
  • [ISO-abbreviation] Medscape J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Mucin-1; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2270873
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97. Zhu Q, Hegde PU, Ricci A Jr, Kane M, Cronin EB, Ardeshirpour Y, Xu C, Aguirre A, Kurtzman SH, Deckers PJ, Tannenbaum SH: Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis. Radiology; 2010 Aug;256(2):367-78
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  • PURPOSE: To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast.
  • One hundred seventy-eight consecutive women (mean age, 52 years; range, 21-89 years) who underwent US-guided biopsy were imaged with a hand-held probe consisting of a coregistered US transducer and an NIR imager.
  • RESULTS: There were two in situ carcinomas (Tis), 35 T1 carcinomas, 24 T2-T4 carcinomas, and 114 benign lesions.
  • The mean maximum and mean average tHb of the benign group were 55.1 micromol/L +/- 22.7 and 39.1 micromol/L +/- 14.9, respectively.
  • Both mean maximum and mean average tHb levels were significantly higher in the malignant groups than they were in the benign group (P < .001).
  • CONCLUSION: The angiogenesis (tHb) contrast imaged by using the NIR technique with US holds promise as an adjunct to mammography and US for distinguishing early-stage invasive breast cancers from benign lesions.

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  • (PMID = 20571122.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB002136
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2909434
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98. Guo AT, Wei LX, Song X: [Histologic classification and prognostic implication of pseudomyxoma peritonei]. Zhonghua Bing Li Xue Za Zhi; 2007 Jul;36(7):474-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On the other hand, the presence of appendiceal tumor, parenchymal invasion of abdominal viscera, cellularity, architecture, nuclear atypia and mitotic activity of the peritoneal lesion significantly correlated with survival.
  • CONCLUSIONS: In general, the 10-year survival rate of PMP was low, despite the relatively benign-looking or low-grade pathologic appearance.
  • [MeSH-minor] Adult. Aged. Appendectomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Survival Rate. Young Adult

  • Genetic Alliance. consumer health - Pseudomyxoma peritonei.
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  • (PMID = 17845762.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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99. Murata S, Herman P, Iwashina M, Mochizuki K, Nakazawa T, Kondo T, Nakamura N, Lakowicz JR, Katoh R: Application of microscopic Forster resonance energy transfer to cytological diagnosis of the thyroid tumors. J Biomed Opt; 2005 May-Jun;10(3):034008
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  • We have employed the microscopic FRET imaging for investigation of six papillary carcinomas and eight benign cases.
  • We have not found significant difference of the mean FRET efficiency between the benign and malignant groups.
  • On the other hand, the texture analysis revealed a significant difference of the intranuclear spatial distribution of FRET efficiencies between the benign and malignant groups.
  • The results indicate that despite the similar average distance between the AT- and the GC-rich DNA segments in the papillary carcinomas and the benign cases, the former has more heterogeneous distribution of the AT- and the GC-rich DNA segments in nuclei compared to the benign groups.
  • [MeSH-major] DNA, Neoplasm / ultrastructure. Fluorescence Resonance Energy Transfer / methods. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Microscopy, Fluorescence, Multiphoton / methods. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
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  • [Copyright] 2005 Society of Photo-Optical Instrumentation Engineers.
  • (PMID = 16229652.001).
  • [ISSN] 1083-3668
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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100. Nonomura K, Shimamoto K, Hatasa K, Mizuno M, Machida K, Mizuno H, Tanaka H, Sakakibara S: Differential diagnosis of breast mass image-forming lesions based on changes in depth-width ratio and internal echo intensity by hand-held probe compression. J Med Ultrason (2001); 2008 Jun;35(2):63-9
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  • [Title] Differential diagnosis of breast mass image-forming lesions based on changes in depth-width ratio and internal echo intensity by hand-held probe compression.
  • However, this is only a subjective estimation under real-time observation; consequently, quantitative evaluation of tumor deformation and the percentage change in internal echo intensity was attempted based on changes in the depth-width ratio and in the internal echo intensity on hand-held probe compression.
  • We evaluated the usefulness of these measurements in the differential diagnosis of benign and malignant tumors.
  • METHODS: The subjects were 139 patients (89 benign and 50 malignant cases) who underwent breast ultrasonography with a 10-MHz (from 4-to 10-MHz) linear probe.
  • RESULTS: There was a significant difference in the D.I. between benign lesions (35.5% ± 14.7%) and malignant lesions (15.4% ± 6.2%) (P < 0.001).
  • The cut-off ratio in differentiating benign from malignant lesions was approximately 25%.
  • The rate of change in echo intensity of benign lesions (149.7% ± 34.3%) was significantly higher than that of malignant lesions (122.9% ± 19.9%) (P < 0.001).

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  • [Keywords] NOTNLM ; breast neoplasm / deformation index / mammary / tissue characterization / ultrasonography
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