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1. Wang YQ, Sun YE, Zhang JM, Liu X: [Clinical practice of 99mTc-peplimycin imaging and radio guided surgery for lung neoplasms]. Ai Zheng; 2003 Jul;22(7):749-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical practice of 99mTc-peplimycin imaging and radio guided surgery for lung neoplasms].
  • BACKGROUND & OBJECTIVE: Intraoperatively,the routine method to differentiate malignant lung neoplasms from benign lesions is by the judgment of naked eye or frozen section.
  • It is not accurate to judge by naked eye and will take long time by frozen section.
  • This study was preliminary clinical practice of tumor imaging and radioimmunoguided surgery (RGS) using (99m)Tc-PPM (peplomycin) as a tumor tracer.
  • Region of interest (ROI) method was performed and tumor-to- normal-tissue (T/NT) ratio was calculated on the image.
  • T/NT ratio was obtained by comparing the radioactivity of the tumor tissue with the normal lung tissue.
  • RESULTS: The uptake ratios (T/NT) of (99m)Tc-PPM were different between malignant and benign lesion (P< 0.01).
  • The ratio (T/NT, x+/-2s) was regarded as the threshold for differentiation of malignant and benign lesions.
  • CONCLUSION: (99m)Tc-PPM is a useful agent in differentiating malignant lung neoplasm from benign lesions, and as a tumor tracer can be used in detecting tumor by GDP intraoperatively.
  • The RGS is a simple method that can help the surgeon in the intraoperative assessment of the tumor and the lymph node metastases.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Lung Neoplasms / radionuclide imaging. Lung Neoplasms / surgery. Peplomycin / administration & dosage. Technetium

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  • (PMID = 12866969.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 56H9L80NIZ / Peplomycin; 7440-26-8 / Technetium
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2. Robinson JW, Brownstein S, Jordan DR, Hodge WG: Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. Surv Ophthalmol; 2006 Sep-Oct;51(5):513-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature.
  • The woman was undergoing mitomycin C injections for ocular cicatricial pemphigoid, diagnosed in the same eye 2 years prior to identification of the neoplasm.
  • The tumor invaded the cornea, sclera, lacrimal gland, regional small nerves, and lymphatics, but did not show intraocular involvement.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Conjunctival Neoplasms / pathology. Conjunctivitis / complications. Pemphigoid, Benign Mucous Membrane / complications
  • [MeSH-minor] Basement Membrane / pathology. Biopsy. Drug Therapy, Combination. Female. Fluorometholone / therapeutic use. Humans. Middle Aged. Mitomycin / therapeutic use. Neoplasm Invasiveness. Ofloxacin / therapeutic use


3. McKenna M, Brodsky L: Extraesophageal acid reflux and recurrent respiratory papilloma in children. Int J Pediatr Otorhinolaryngol; 2005 May;69(5):597-605
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Recurrent respiratory papillomatosis (RRP) is a benign infectious disease which is caused by the human papilloma virus (HPV).
  • The clinical course of the papillomatosis and the diagnosis and treatment of reflux are compared over time.
  • Lapses in compliance with medications or behavioral and dietary recommendations in three out of four patients led to a rebound in symptoms and signs of RRP, including worsening of vocal quality and the endoscopic appearance of the larynx.
  • Prompt diagnosis and effective treatment of EERD should be considered in all patients with difficult to control RRP or with clinical presentation or endoscopic signs of EERD.
  • [MeSH-major] Gastroesophageal Reflux / complications. Gastroesophageal Reflux / diagnosis. Laryngeal Neoplasms / complications. Neoplasm Recurrence, Local / complications. Papilloma / complications
  • [MeSH-minor] Airway Obstruction / etiology. Airway Obstruction / therapy. Child. Child, Preschool. Humans. Male. Papillomaviridae. Papillomavirus Infections / complications. Papillomavirus Infections / therapy. Severity of Illness Index. Tumor Virus Infections / complications. Tumor Virus Infections / therapy

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  • [CommentIn] Int J Pediatr Otorhinolaryngol. 2006 Apr;70(4):757-8; author reply 759 [16242786.001]
  • (PMID = 15850681.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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4. Kadashev BA, Kutin MA, Kalinin PL, Trunin IuK, Alekseev SN, Shkarubo AN: [Comparative assessment of the results of different surgical treatments in patients with pituitary adenomas infiltrating the cavernous sinus]. Zh Vopr Neirokhir Im N N Burdenko; 2004 Jul-Sep;(3):14-7; discussion 17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign pituitary tumors or adenomas are highly common, occasionally inclined to infiltrate the adjacent structures, the cavernous sinus in particular.
  • Despite the fact that drug and radiation therapy are at present widely used treatments, surgical procedures remain highly topical.
  • Different modifications of two basic surgical methods (transcranial intradural and transsphenoidal) that fail to completely remove a tumor from the cavernous sinus in most cases are mostly frequently used as before.
  • Attempts to improve surgical procedures and introduction of current technologies have led to the emergence of an extradural method for tumor removal from the cavernous sinus and to the introduction of endoscopic monitoring during transsphenoidal operations.
  • However, this method has a number of limitations in cases with tumor being grown into the cavernous sinus especially when there is a medial displacement of the intracavernous segment of the internal carotid artery.
  • Moreover, secondary tumor nodes that may be removed by transcranial intradural access are a contraindication to its use.
  • With this, attempts to remove a tumor from the cavernous sinus fail to ensure the desired completeness of removal from the cavernous sinus.
  • The application of an intra-extradural access is the most adequate procedure for tumor removal from the cavernous sinus.
  • The two-stage removal is the most adequate procedure in cases of simultaneously significant spread of a tumor intracranially and into the structures of the base of the skull.
  • [MeSH-major] Adenoma / surgery. Cavernous Sinus / pathology. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery. Vascular Neoplasms / surgery
  • [MeSH-minor] Activities of Daily Living. Adult. Endocrine System Diseases / etiology. Eye Diseases / etiology. Female. Humans. Male. Neoplasm Invasiveness. Postoperative Complications / etiology. Retrospective Studies. Survival Rate

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  • (PMID = 15490633.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia
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5. Canovas D, Rennie IG, Nichols CE, Sisley K: Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory. Cancer; 2008 Apr 15;112(8):1787-94
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  • Tumor location, and the baseline invasion of the melanoma, affected the ability of aqueous and vitreous from different patients to regulate invasive behavior.
  • CONCLUSIONS: The findings suggest that in situ uveal melanoma development reflects an interaction between the tumor and the environment of the eye.
  • Exposure to the aqueous would therefore contribute to the benign nature of iris melanomas, whereas potential interaction with the vitreous appears to promote the aggressive behavior of posterior uveal melanomas.
  • [MeSH-major] Aqueous Humor / physiology. Melanoma / pathology. Uveal Neoplasms / pathology. Vitreous Body / physiopathology
  • [MeSH-minor] Adult. Aged. Anticarcinogenic Agents / pharmacology. Carcinogens / pharmacology. Cell Line, Tumor. Cell Proliferation. Chemotaxis / physiology. Choroid Neoplasms / pathology. Ciliary Body / pathology. Cytokines / drug effects. Female. Follow-Up Studies. Humans. Iris Neoplasms / pathology. Male. Middle Aged. Neoplasm Invasiveness. Tissue Culture Techniques. Tissue Inhibitor of Metalloproteinase-2 / drug effects. Tissue Inhibitor of Metalloproteinase-3 / drug effects. Transforming Growth Factor beta2 / drug effects

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  • (PMID = 18300240.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Carcinogens; 0 / Cytokines; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / Transforming Growth Factor beta2; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2
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