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Items 1 to 100 of about 1189
1. Andreani SM, Ratnasingham K, Dang HH, Gravante G, Giordano P: Crohn's disease of the vulva. Int J Surg; 2010;8(1):2-5
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  • [Title] Crohn's disease of the vulva.
  • Crohn's involvement of the Vulva is unfamiliar and difficult to treat.
  • The aim is to review the presentation, clinical course and different treatments of Vulva Crohn's disease (CD).
  • We have reviewed the literature without language barrier from 1966 to 2009 through Pubmed with the following words: vulva and CD, vulvitis and CD, genital CD.
  • We included articles that had Crohn's involvement of the vulva arising from a distant site (metastatic) or arising from a Crohn's fistula from the perineum and/or anorectum.
  • Fifty-five cases of CD of the vulva were included in the final anlaysis of this review.
  • Vulva involvement is rare and gives long-term discomfort.
  • CD is often unrecognized cause of vulva pain and difficult to diagnose.
  • [MeSH-major] Crohn Disease / surgery. Vulvar Diseases / surgery
  • [MeSH-minor] Anti-Infective Agents / therapeutic use. Anti-Inflammatory Agents / therapeutic use. Combined Modality Therapy. Female. Humans. Metronidazole / therapeutic use. Prednisolone / therapeutic use

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  • [Copyright] Copyright 2009 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19800432.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Anti-Inflammatory Agents; 140QMO216E / Metronidazole; 9PHQ9Y1OLM / Prednisolone
  • [Number-of-references] 53
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2. Amouri M, Masmoudi A, Boudaya S, Amouri A, Ben Ali I, Bouassida S, Guermazi M, Turki H: Acquired lymphangioma circumscriptum of the vulva. Dermatol Online J; 2007;13(4):10
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  • [Title] Acquired lymphangioma circumscriptum of the vulva.
  • Lymphangiomas are rare benign proliferations of the lymphatic system.
  • Acquired lymphangioma circumscriptum of the vulva is induced by impaired lymph flow.
  • A 45-year-old female presented with swelling of the vulva for the past 8 years.
  • Her vulval swelling did not respond and was diagnosed as acquired lymphangioma circumscriptum.
  • She becomes the fifth reported case of acquired lymphangioma circumscriptum of the vulva with tubercular lymphadenitis.
  • [MeSH-major] Lymphangioma / etiology. Tuberculosis, Lymph Node / complications. Vulvar Neoplasms / etiology
  • [MeSH-minor] Antitubercular Agents / therapeutic use. Female. Humans. Middle Aged

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  • (PMID = 18319007.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents
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3. O'Connell TX, Nathan LS, Satmary WA, Goldstein AT: Non-neoplastic epithelial disorders of the vulva. Am Fam Physician; 2008 Feb 1;77(3):321-6
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  • [Title] Non-neoplastic epithelial disorders of the vulva.
  • Lichen sclerosus, lichen planus, and lichen simplex chronicus are three of the most common non-neoplastic epithelial disorders of the vulva.
  • Lichen sclerosus is characterized by intense vulvar itching and can affect men and women of all ages, but it manifests most commonly in postmenopausal women.
  • Lichen planus is an inflammatory autoimmune disorder that can affect the vulva and the vagina; it peaks in incidence between ages 30 and 60.
  • There are three clinical variants of lichen planus affecting the vulva: erosive, papulosquamous, and hypertrophic.
  • Lichen simplex chronicus is caused by persistent itching and scratching of the vulvar skin, which results in a thickened, leathery appearance.
  • It is thought to be an atopic disorder in many cases and may arise in normal skin as a result of psychological stress or environmental factors.
  • Definitive diagnosis of non-neoplastic disorders depends on the histology of biopsied tissue.
  • [MeSH-major] Skin Diseases / diagnosis. Skin Diseases / therapy. Vulvar Diseases / diagnosis. Vulvar Diseases / therapy
  • [MeSH-minor] Dermatologic Agents / therapeutic use. Female. Humans. Lichen Planus / diagnosis. Lichen Planus / therapy. Neurodermatitis / diagnosis. Neurodermatitis / therapy. Patient Education as Topic. Vulvar Lichen Sclerosus / diagnosis. Vulvar Lichen Sclerosus / therapy

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  • [SummaryForPatientsIn] Am Fam Physician. 2008 Feb 1;77(3):330 [18297957.001]
  • (PMID = 18297956.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dermatologic Agents
  • [Number-of-references] 44
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4. Bertozzi S, Londero AP, Fruscalzo A, Marchesoni D, Lellé RJ: [Paget disease of the vulva: resolution after local treatment with imiquimod--report of a case and review of the literature]. Gynakol Geburtshilfliche Rundsch; 2009;49(4):326-30
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  • [Title] [Paget disease of the vulva: resolution after local treatment with imiquimod--report of a case and review of the literature].
  • [Transliterated title] Morbus Paget der Vulva: Remission durch Lokalbehandlung mit Imiquimod--Fallbericht und Literaturübersicht.
  • Paget disease is a rare disorder of the skin of the vulva, comprising less than 1% of vulvar neoplasms.
  • Thus, topical imiquimod is not only effective as treatment of vulvar intraepithelial neoplasia, but may also be used for selected patients with recurrent Paget disease as an alternative to repeat surgical interventions.
  • [MeSH-major] Aminoquinolines / administration & dosage. Antineoplastic Agents / administration & dosage. Neoplasm Recurrence, Local / drug therapy. Paget Disease, Extramammary / drug therapy. Vulvar Neoplasms / drug therapy
  • [MeSH-minor] Administration, Topical. Aged. Chemotherapy, Adjuvant. Colposcopy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Laser Therapy. Vulva / pathology. Vulva / surgery

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  • (PMID = 20530949.001).
  • [ISSN] 1423-0011
  • [Journal-full-title] Gynäkologisch-geburtshilfliche Rundschau
  • [ISO-abbreviation] Gynakol Geburtshilfliche Rundsch
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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5. Nava Flores EL, Alvarez Blanco MA, Figueroa Vadillo J, Cruz Ortiz H: [Aggressive angiomyxoma of the vulva. Case report and literature review]. Ginecol Obstet Mex; 2009 Oct;77(10):487-90
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  • [Title] [Aggressive angiomyxoma of the vulva. Case report and literature review].
  • [Transliterated title] Angiomixoma agresivo de la vulva. Informe de un caso y revisión de la bibliografía.
  • Aggressive angiomyxoma is a rare vulvovaginal, perineal or pelvic mesenchymal neoplasm with a marked tendency to local recurrence but does not metastasize.
  • A case of an aggressive angiomyxoma of vulva in a 39-years-old women with an illness of one year prior to examination, with a slow and progressive growth of the left vulvar region, without other symptoms.
  • During physical examination, a piriform tumor of 15x10 cm was found, located on the left labia majora, soft tissue dependent.
  • Wide resection of the tumor were performed.
  • Hystopathology reported an aggressive angiomyxoma of the vulva, with tumor in resection margins.
  • Aggressive angiomyxoma is a rare neoplasm 150 cases has been reported.
  • [MeSH-major] Myxoma / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 19902678.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 16
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6. Fábregues A, Colmenero I, Torrelo A, Azorín D, de Prada I, Contra T, González-Mediero I, Zambrano A: [Congenital botryoid rhabdomyosarcoma of the vulva]. Actas Dermosifiliogr; 2005 Apr;96(3):188-90
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  • [Title] [Congenital botryoid rhabdomyosarcoma of the vulva].
  • [Transliterated title] Rabdomiosarcoma botrioides congénito de vulva.
  • Rhabdomyosarcoma is the most frequent malignant soft tissue tumor in pediatric patients; however, the vulvar location and congenital appearance are exceptional.
  • We present the case of a newborn girl with botryoid rhabdomyosarcoma of the vulva, treated with chemotherapy, conservative surgery and autologous transplant.
  • [MeSH-major] Rhabdomyosarcoma / congenital. Vulvar Neoplasms / congenital
  • [MeSH-minor] Female. Humans. Infant, Newborn

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  • (PMID = 16476365.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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7. Aggarwal K, Gupta S, Jain VK, Marwah N: Congenital lymphangioma circumscriptum of the vulva. Indian Pediatr; 2009 May;46(5):428-9
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  • [Title] Congenital lymphangioma circumscriptum of the vulva.
  • Lymphangioma circumscriptum of the vulva is a disorder of lymphatic channels involving deep dermal tissues.
  • Most of these cases are confused with genital warts leading to improper diagnosis and treatment.
  • We present a three years young female child who had multiple skin colored papular lesions over the genitals.
  • [MeSH-major] Lymphangioma / pathology. Vulva / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Child, Preschool. Female. Humans

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  • (PMID = 19478357.001).
  • [ISSN] 0019-6061
  • [Journal-full-title] Indian pediatrics
  • [ISO-abbreviation] Indian Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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8. Okur MI, Köse R, Yildirim AM, Cobanoğlu B: Lymphangiectasia of the vulva accompanying congenital lymphedema. Dermatol Online J; 2009;15(4):13
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  • [Title] Lymphangiectasia of the vulva accompanying congenital lymphedema.
  • Lymphangiectasia is a benign condition with multiple dilated lymph vessels in the dermis.
  • Vulvar localization is rare and mostly depends on disturbing the lymphatic flow.
  • We present a patient with vulvar lesions and ipsilateral congenital lower extremity lymphedema.
  • Surgical excision eliminated the lymphangiectasia and improved the appearance of the edematous vulva.
  • [MeSH-major] Lymphangiectasis / etiology. Lymphedema / complications. Vulvar Diseases / etiology
  • [MeSH-minor] Adult. Cellulitis / complications. Female. Humans


9. Alvarado Gay FJ, Ramirez Arredondo Mdel C, de la Peña Gutiérrez M: [Sclerosing fibrous hemangiomas in vulva]. Ginecol Obstet Mex; 2009 Feb;77(2):110-3
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  • [Title] [Sclerosing fibrous hemangiomas in vulva].
  • [Transliterated title] Hemangioma fibroso esclerosante en la vulva.
  • We present a case report of a patient that went to consultation for tumoración presence at level vulvar of a year of evolution, with size of 8 x 6 cm, accompanied by pain with the deambulación and manipulation, the out taking of tumoración biopsy, later on resection by means of vulvectomia simple left and the result anatomohistopatológico was corroborated that reported hemangioma fibrous esclerosante.
  • [MeSH-major] Histiocytoma, Benign Fibrous. Vulvar Neoplasms
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 19365953.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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10. Horn LC, Schierle K, Klostermann K, Schnürch HG, Hantschmann P: [Pathoanatomical preparation and reporting of specimens from precancerous lesions and carcinomas of the vulva]. Pathologe; 2009 Feb;30(1):56-64
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  • [Title] [Pathoanatomical preparation and reporting of specimens from precancerous lesions and carcinomas of the vulva].
  • [Transliterated title] Pathologisch-anatomische Aufarbeitung und Befundung von Präparaten bei Präkanzerosen und Karzinomen der Vulva.
  • On the basis of varying morphology and pathogenesis, two types of vulvar intraepithelial neoplasias (VIN) have been defined: the common type (approximately 98%), classic VIN, is characterised by strong association to high-risk HPV infection (up to 90%), occurrence at younger age (median age 30-40 years) and multifocality.
  • It is usually diagnosed in combination with vulvar (keratinizing) squamous cell carcinoma.
  • Prognostically relevant factors in vulvar cancer include stage of disease, inguinal lymph node involvement, size of metastatic deposits and presence of extracapsular extension, depth of invasion and distance of the tumor from resection margins.
  • Tumor grade and the presence of lymphovascular space involvement are controversially discussed.
  • [MeSH-major] Precancerous Conditions / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma in Situ / genetics. Carcinoma in Situ / pathology. Diagnosis, Differential. Female. Genes, p53. Humans. Middle Aged. Neoplasm Invasiveness. Vulva / anatomy & histology. Vulva / pathology. Vulvar Diseases / pathology

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  • (PMID = 19130058.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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11. Hammock LA, Barrett TL: Inflammatory dermatoses of the vulva. J Cutan Pathol; 2005 Oct;32(9):604-11
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  • [Title] Inflammatory dermatoses of the vulva.
  • Inflammatory, non-neoplastic epidermal alterations of the vulva can be correctly diagnosed using classification schemes applied to skin elsewhere on the body.
  • A wide range of inflammatory disorders may occur on the vulva, and they may have a similar clinical presentation to HPV lesions.
  • Accordingly, as inflammatory dermatoses commonly occur on the vulva and are often curable with topical therapy, an awareness of these entities and an ability to distinguish them from HPV are imperative.
  • [MeSH-major] Skin Diseases / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Middle Aged. Papillomavirus Infections / pathology

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  • (PMID = 16176297.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 57
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12. Rausch D, Angermeier M, Capaldi L, Wharton G, Lawrence WD, Robinson-Bostom L: Multinucleated atypia of the vulva. Cutis; 2005 Feb;75(2):118-20
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  • [Title] Multinucleated atypia of the vulva.
  • Multinucleated atypia of the vulva (MAV) is an entity with a distinctive histologic pattern of multinucleation in the basal and middle layers of the squamous epithelium that may mimic human papillomavirus (HPV)-related squamous atypias.
  • MAV is rarely reported in the literature, and we believe it should be considered in the differential diagnosis of flesh-colored vulvar papules and vulvar epidermal atypias with multinucleated squamous cells.
  • We describe the case of a 49-year-old patient with the diagnosis of MAV.
  • Results of histopathologic examination revealed a focal area of multinucleation in the basal to middle epithelial layers of the vulvar squamous epithelium, accompanied by mild hyperkeratosis and chronic inflammation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lichen Sclerosus et Atrophicus / pathology. Papillomavirus Infections / pathology. Skin / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. In Situ Hybridization. Middle Aged. Postmenopause. Risk Assessment

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  • (PMID = 15773533.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Roh MR, Choi YJ, Lee KG: Papular acantholytic dyskeratosis of the vulva. J Dermatol; 2009 Jul;36(7):427-9
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  • [Title] Papular acantholytic dyskeratosis of the vulva.
  • We describe a 63-year-old woman with an asymptomatic papular eruption on the vulva.
  • These clinical and histological findings were consistent with the diagnosis of papular acantholytic dyskeratosis of the vulva which is a rare disorder, first described in 1984.
  • [MeSH-major] Acantholysis / pathology. Keratosis / pathology. Skin Diseases, Papulosquamous / diagnosis. Vulvar Diseases / pathology
  • [MeSH-minor] Female. Humans. Middle Aged

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  • (PMID = 19583693.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Kiyohara H, Kato S, Ohno T, Ohkubo Y, Tamaki T, Kamada T: Carbon ion radiotherapy for malignant melanoma of female genital organs. J Clin Oncol; 2009 May 20;27(15_suppl):e16548

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  • [Title] Carbon ion radiotherapy for malignant melanoma of female genital organs.
  • : e16548 Background: Malignant melanoma of the female genital organs is a very rare tumor and resistant to conventional photon radiotherapy.
  • We report six cases of female genital malignant melanoma those were well controlled locally by carbon ion radiotherapy (CIRT).
  • METHODS: Between November 2004 and October 2008, six patients with unresectable female genital malignant melanoma were treated with CIRT.
  • The tumor located in the vagina (4 patients), both the cervix and the vagina (1 patient), or both the vagina and the vulva (1 patient).
  • CONCLUSIONS: CIRT achieved favorable local tumor control without developing severe acute and late toxicity in the treatment of unresectable malignant melanoma of the female genital organs.

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  • (PMID = 27960818.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Stock I: [Fungal diseases of vulva and vagina caused by Candida species]. Med Monatsschr Pharm; 2010 Sep;33(9):324-33; quiz 335-6

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  • [Title] [Fungal diseases of vulva and vagina caused by Candida species].
  • [Transliterated title] Pilzerkrankungen der Vulva und Vagina durch Candida-arten.
  • Fungal diseases of vulva and vagina attributed to Candida species (vulvovaginal candidosis) are the most frequent mycoses of women.
  • [MeSH-minor] Candida / physiology. Diagnosis, Differential. Female. Humans. Infant, Newborn. Risk Factors

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  • (PMID = 21192442.001).
  • [ISSN] 0342-9601
  • [Journal-full-title] Medizinische Monatsschrift für Pharmazeuten
  • [ISO-abbreviation] Med Monatsschr Pharm
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antifungal Agents
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16. Uke MS, Kulkarni MB, Ajit D, Gujral S: Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):907-10

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  • [Title] Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report.
  • BACKGROUND: Hidradenoma papilliferum is a rare benign tumor of the vulva that occurs mainly in women in the skin of the anogenital region.
  • Clinically it may mimic a carcinoma, so the correct cytologic interpretation of the tumor cells with subsequent careful histologic confirmation is essential for good management.
  • Fine needle aspiration cytology and vulvar scraping of the lesion were reported as a malignant tumor, and the case was referred to our center for further management.
  • Repeat vulvar smears showed mainly groups and clusters of benign-looking glandular cells and were interpreted as a benign tumor.
  • Subsequent histology confirmed the diagnosis of hidradenoma papilliferum.
  • The clinical presentation should not mislead the cytologic interpretation of the tumor cells.
  • [MeSH-major] Acrospiroma / diagnosis. Cytological Techniques. Sweat Gland Neoplasms / diagnosis. Vulva / pathology
  • [MeSH-minor] Female. Humans. Middle Aged

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  • (PMID = 21053567.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Kabir N, Ara I, Ahmed A, Muhsin AU: Verrucous carcinoma of vulva. Mymensingh Med J; 2007 Jul;16(2 Suppl):S53-56
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  • [Title] Verrucous carcinoma of vulva.
  • Vulval carcinoma is an uncommon disease of old women and may manifest as verrucous carcinoma.
  • Invasive carcinoma of vulva usually appears long time after intraepithelial neoplasia or chronic irritation.
  • We are presenting one young lady of 21 years who noticed whitening of vulva since her childhood and irregular vulval itching in that area.
  • Further investigation revealed the lesion to be as verrucous carcinoma of vulva.
  • Any persistent complaints of vulva like itching, discharge, even ulcer should be taken care of for detection of intraepithelial vulvar cancer.

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  • (PMID = 17917632.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
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18. Stehman FB, Look KY: Carcinoma of the vulva. Obstet Gynecol; 2006 Mar;107(3):719-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the vulva.
  • The objective of this review is to summarize the published data about squamous carcinoma of the vulva and to identify promising areas for future investigation.
  • Rather than the routine use of complete radical vulvectomy, a radical wide excision of the vulvar lesion to achieve at least a 1-cm gross margin appears sufficient to treat the primary lesion.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Vulvar Neoplasms / therapy
  • [MeSH-minor] Female. Humans. Lymphatic Metastasis. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Postoperative Complications / epidemiology. Prognosis. Quality of Life

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  • (PMID = 16507947.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 168
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19. Dainese E, Sessa F, Riva C, Placidi C, Capella C: ["Proximal type" epithelioid sarcoma of the vulva: differential diagnosis with other extrarenal rhabdoid tumors]. Pathologica; 2005 Jun;97(3):133-6
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  • [Title] ["Proximal type" epithelioid sarcoma of the vulva: differential diagnosis with other extrarenal rhabdoid tumors].
  • [Transliterated title] Sarcoma epitelioide di tipo prossimale della vulva: diagnosi differenziale con altri tumori rabdoidi extrarenali.
  • Proximal type epithelioid sarcoma is a rare neoplasia in which morphological findings are characterized by nodular proliferation of epithelioid cells with focal rhabdoid features.
  • It shares some histological features with other neoplasias and this gives an account of several differential diagnosis with other extrarenal rhabdoid tumors.
  • Immunohistochemical and ultrastructural analysis are important in defining this entity: vimentin, cytokeratin, EMA and often CD34 expression of tumoral cells, moreover ultrastructurally evidence of large paranuclear whorls of intermediate filaments, are requested for diagnosis.
  • A correct diagnostic framing is necessary because of the aggressive clinical behaviour of this tumor, that has a tendency to early spreading.
  • We describe a case of vulvar proximal type epithelioid sarcoma in a 34 years old woman.
  • [MeSH-major] Diagnostic Errors. Sarcoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Epidermal Cyst / diagnosis. Female. Humans. Intermediate Filaments / pathology. Lymph Node Excision. Mucin-1 / analysis. Neoplasm Proteins / analysis. Reoperation. Rhabdoid Tumor / classification. Rhabdoid Tumor / diagnosis

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  • (PMID = 16259280.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Neoplasm Proteins
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20. Masmoudi A, Bouassida S, Ayadi L, Elloumi Y, Khabir A, Boudawara T, Turki H, Zahaf A: [Giant sebaceous gland hyperplasia of the vulva]. Ann Dermatol Venereol; 2006 Jun-Jul;133(6-7):571-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant sebaceous gland hyperplasia of the vulva].
  • [Transliterated title] Hyperplasie géante des glandes sébacées de la vulve.
  • BACKGROUND: Sebaceous gland hyperplasia is an epithelial tumour with sebaceous differentiation.
  • In this paper, we report a new case of sebaceous gland hyperplasia of the vulva.
  • The cutaneous biopsy confirmed the diagnosis of sebaceous gland hyperplasia of the vulva.
  • [MeSH-major] Sebaceous Glands / pathology. Vulva / pathology
  • [MeSH-minor] Adult. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / surgery

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  • (PMID = 16885847.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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21. Tjalma WA, Colpaert CG: Myxoid leiomyosarcoma of the vulva. Gynecol Oncol; 2005 Feb;96(2):548-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid leiomyosarcoma of the vulva.
  • BACKGROUND: Myxoid leiomyosarcoma (MLMS) of the vulva is a mesenchymal tumor with only five reported cases in the literature.
  • CASE: We report an 85-year-old woman with a unilateral nonulcerating, painless vulvar mass.
  • Initial biopsies were benign.
  • However, clinically, this lesion was suspicious for a soft tissue tumor.
  • Definitive histology revealed a myxoid leiomyosarcoma of the vulva.
  • CONCLUSIONS: Vulvar myxoid leiomyosarcomas are rare and can be confused with other benign or malignant tumors.
  • It is important to be aware of this rare tumor variant, in order to plan appropriate treatment.
  • [MeSH-major] Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans

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  • (PMID = 15661250.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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22. Verma S: Pregnancy-induced lymphangiectasias of the vulva. Int J STD AIDS; 2008 Mar;19(3):211-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pregnancy-induced lymphangiectasias of the vulva.
  • More so because these lesions occurring on the vulva can mimic various other entities and can sometimes be misconstrued as sexually transmitted disease by persons involved in primary care.
  • [MeSH-major] Lymphangiectasis / etiology. Pregnancy Complications / diagnosis. Vulvar Diseases / etiology
  • [MeSH-minor] Adult. Female. Humans. Pregnancy

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  • (PMID = 18397567.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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23. Thompson BE, Lamont LB, Kimble J: Germ-line induction of the Caenorhabditis elegans vulva. Proc Natl Acad Sci U S A; 2006 Jan 17;103(3):620-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germ-line induction of the Caenorhabditis elegans vulva.
  • Development of the Caenorhabditis elegans vulva serves as a paradigm for intercellular signaling during animal development.
  • In wild-type animals, the somatic gonadal anchor cell generates the LIN-3/EGF ligand to induce vulval fates in the underlying hypodermis, whereas FBF, FOG-1, and FOG-3 control germ-line development.
  • Here we report that FBF functions redundantly with FOG-1 and FOG-3 to control vulval induction: animals lacking FBF and either FOG-1 or FOG-3 have multiple vulvae, the Muv phenotype.
  • The fog; fbf Muv phenotype is generated by aberrant induction of vulval precursor cells (VPCs): in wild-type animals, three VPCs are induced to form a single vulva, but, in fog; fbf mutants, four or five VPCs are typically induced, resulting in ectopic vulvae.
  • The simplest interpretation is that FOG-1, FOG-3, and FBF act in the germ line to influence vulval fates.

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  • (PMID = 16407099.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM069454; United States / NIGMS NIH HHS / GM / T32 GM007215; United States / NIGMS NIH HHS / GM / GM069454; United States / NIGMS NIH HHS / GM / T32 GM07215
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / FOG-3 protein, C elegans; 0 / RNA, Messenger; 0 / RNA-Binding Proteins; 0 / fem-3-binding protein, C elegans; 0 / fog-1 protein, C elegans; 148412-70-8 / Lin-3 protein, C elegans; 62229-50-9 / Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC1334682
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24. Okur MI, Yildirim AM, Köse R: Severe haematoma of the vulva and defloration caused by goring. Eur J Obstet Gynecol Reprod Biol; 2005 Apr 1;119(2):250-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Severe haematoma of the vulva and defloration caused by goring.
  • Haematoma of the vulva may occur following a trauma due to its highly vascular structure.
  • We present a case of haematoma of the vulva caused by goring by a cow.
  • [MeSH-major] Hematoma / etiology. Hymen / injuries. Vagina / injuries. Vulva / injuries. Vulvar Diseases / etiology
  • [MeSH-minor] Adolescent. Animals. Cattle. Female. Horns. Humans. Suture Techniques

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  • (PMID = 15808390.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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25. Dordević M, Jovanović B, Mitrović S, Dordević G: Ectopic mammary tissue in vulva. Vojnosanit Pregl; 2008 May;65(5):407-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic mammary tissue in vulva.
  • CASE REPORT: A woman, 27-year old, admitted to Obstetrics and Gynecology Clinic Kragujevac for surgery, of goose-egg size, vulva tumor, of elastic consistency.
  • Excision of the tumor was completely done in the total endotracheal anesthesia.
  • CONCLUSION: Ectopic mammary tissue in vulva in adult period is very rarely seen, and can be changed pathologically as well as normally positioned breast tissue into benign cystic changes, benign tumors, adenomas and fibroadenomas and tumors.
  • [MeSH-major] Choristoma / pathology. Mammary Glands, Human. Vulvar Diseases / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18630137.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia
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26. Hauth EA, Kimmig R, Forsting M: [Diagnosis of vulval and vaginal neoplasms with magnetic resonance imaging]. Gynakol Geburtshilfliche Rundsch; 2007;47(4):226-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis of vulval and vaginal neoplasms with magnetic resonance imaging].
  • [Transliterated title] Verwendung der Magnetresonanztomographie in der Diagnostik von Neoplasien der Vulva und Vagina.
  • Magnetic resonance imaging (MRI) is widely accepted as an established method in the diagnostic imaging of diseases of the female pelvis.
  • This review article describes the role of MRI in the diagnosis of neoplasms of the vulva and the vagina.
  • MRI is useful in the pretherapeutic staging of vulval and vaginal neoplasms in order to assess tumor size, local tumor extent and presence of lymph node metastases.
  • Further indications for MRI are the diagnosis of posttherapeutic changes and tumor recurrence.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Vagina / pathology. Vaginal Neoplasms / diagnosis. Vulva / pathology. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17914269.001).
  • [ISSN] 1423-0011
  • [Journal-full-title] Gynäkologisch-geburtshilfliche Rundschau
  • [ISO-abbreviation] Gynakol Geburtshilfliche Rundsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 26
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27. Kimball KJ, Straughn JM, Conner MG, Kirby TO: Recurrent basosquamous cell carcinoma of the vulva. Gynecol Oncol; 2006 Aug;102(2):400-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent basosquamous cell carcinoma of the vulva.
  • BACKGROUND: Basosquamous cell carcinoma (BSC) of the vulva is a rare entity with interesting prognostic and therapeutic implications.
  • CASE: A case of recurrent BSC of the vulva treated with unilateral radical vulvectomy and unilateral lymph node dissection is reported.
  • CONCLUSION: BSC is a rare disorder of the vulva.
  • The metastatic potential of this tumor is not fully understood, but likely is intermediate between squamous cell carcinoma and basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Basosquamous / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Lymph Node Excision

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  • (PMID = 16624392.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Mottl H, Rob L, Stary J, Kodet R, Drahokoupilova E: Langerhans cell histiocytosis of vulva in adolescent. Int J Gynecol Cancer; 2007 Mar-Apr;17(2):520-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Langerhans cell histiocytosis of vulva in adolescent.
  • Langerhans cell histiocytosis (LCH) affecting child vulva alone is a very rare disease.
  • Only 13 cases of primary vulvar LCH have been previously reported in the medical literature.
  • We describe an additional case in which the LCH was confined to the vulva, with review of the literature.
  • A metastatic work-up did not reveal any evidence of the disease except on the vulva.
  • The patient was diagnosed with a recurrent disorder in the vulva 8 months after the completion of primary chemotherapy.
  • Primary LCH of vulva is very unusual, but we have to keep in mind this possibility when an adolescent girl presents with an atypical chronic lesion on the vulva.
  • This patient appears to be the first case of adolescent 16.5 year old having a solely cutaneous lesion of the vulva.
  • [MeSH-major] Histiocytosis, Langerhans-Cell / diagnosis. Vulvar Diseases / diagnosis
  • [MeSH-minor] Adolescent. Female. Humans

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  • (PMID = 17362323.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Sáenz AM, Cirocco A, Avendaño M, González F, Sardi JR: Papular acantholytic dyskeratosis of the vulva. Pediatr Dermatol; 2005 May-Jun;22(3):237-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papular acantholytic dyskeratosis of the vulva.
  • We describe an 11-year-old girl with a persistent pruritic papular eruption on the vulva.
  • Those findings were consistent with a diagnosis of acantholytic dyskeratosis.
  • [MeSH-major] Acantholysis / diagnosis. Keratosis / diagnosis. Vulvar Diseases / diagnosis
  • [MeSH-minor] Biopsy. Child. Diagnosis, Differential. Female. Humans

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  • (PMID = 15916573.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Fernandez Flores A, Mallo S: Langerhans cell histiocytosis of vulva. Dermatol Online J; 2006;12(1):15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Langerhans cell histiocytosis of vulva.
  • Cutaneous involvement of the vulva by Langerhans cell histiocytosis in women older than 70 is a rare phenomenon.
  • We present a case of a 72-year-old woman, who had cutaneous vulvar involvement by Langerhans-cell histiocytosis, diagnosed by biopsy.
  • [MeSH-major] Histiocytosis, Langerhans-Cell / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Administration, Topical. Adrenal Cortex Hormones / administration & dosage. Adrenal Cortex Hormones / therapeutic use. Aged. Female. Groin. Humans. Skin Diseases / drug therapy. Skin Diseases / metabolism. Skin Diseases / pathology. Treatment Outcome

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  • (PMID = 16638383.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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31. Haidopoulos D, Diakomanolis E, Rodolakis A, Voulgaris Z, Vlachos G, Michalas S: Coexistence of verrucous and squamous carcinoma of the vulva. Aust N Z J Obstet Gynaecol; 2005 Feb;45(1):60-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of verrucous and squamous carcinoma of the vulva.
  • AIM: To evaluate the coexistence of verrucous and squamous carcinoma of the vulva and to assess the clinical course, survival and rate of recurrent disease of these patients.
  • METHODS: The records of 17 patients who were diagnosed with verrucous carcinoma of the vulva over a 12-year period were studied retrospectively.
  • Presence of genuine verrucous carcinoma or coexistence of verrucous and squamous carcinoma of the vulva on vulvar biopsies, results of histopathological assessment of final vulva and inguino-femoral node specimens and histological evaluation of recurrent disease specimens were the main outcome measures.
  • Three women (17.5%) presented with local relapse of the tumour, and were managed by wide local excision of the tumour.
  • CONCLUSIONS: In the present study, 35% of patients with verrucous carcinomas of the vulva had coexistent squamous carcinoma.
  • Separation of the cases of genuine verrucous carcinoma from coexistent verrucous and squamous tumours is based on the establishment of correct diagnosis by a large and deep vulvar biopsy as well as the meticulous assessment of the specimen by the pathologist.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Verrucous / pathology. Neoplasms, Multiple Primary / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Humans. Middle Aged

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  • (PMID = 15730367.001).
  • [ISSN] 0004-8666
  • [Journal-full-title] The Australian & New Zealand journal of obstetrics & gynaecology
  • [ISO-abbreviation] Aust N Z J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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32. Farage M, Maibach H: Lifetime changes in the vulva and vagina. Arch Gynecol Obstet; 2006 Jan;273(4):195-202
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  • [Title] Lifetime changes in the vulva and vagina.
  • The morphology and physiology of the vulva and vagina change over a lifetime.
  • The mucosa of the vulvar vestibule, which originates from the embryonic endoderm, is non-keratinized.
  • At birth, the vulva and vagina exhibit the effects of residual maternal estrogens.
  • During puberty, the vulva and vagina acquire mature characteristics in a sequential fashion in response to adrenal and gonadal maturation.
  • Vulvar skin thickness remains unchanged but menstrual cycle-associated changes in ortho- and parakeratosis occur at the cytological level.
  • The vulva and vagina further adapt to the needs of pregnancy and delivery.
  • Post-menopausal changes in skin barrier function, skin hydration, and irritant susceptibility have been observed on exposed skin but not on the vulva.
  • [MeSH-major] Aging / physiology. Sexual Development / physiology. Vulva / physiology
  • [MeSH-minor] Female. Humans. Menopause / physiology. Vagina / embryology. Vagina / growth & development. Vagina / physiology

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  • (PMID = 16208476.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 58
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33. Farage M, Warren R, Wang-Weigand S: The vulva is relatively insensitive to menses-induced irritation. Cutan Ocul Toxicol; 2005;24(4):243-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The vulva is relatively insensitive to menses-induced irritation.
  • Skin patch testing of menses and venous blood on the vulva (labia majora) and the upper arm was performed to assess the potential contribution of these biological fluids to vulvar irritation during menstruation.
  • The relative insensitivity of the vulva to irritation by menses or blood was not predictable a priori because some irritants elicit heightened responses on the vulva relative to the arm (3).
  • These results suggest that the vulva (labia majora) may be adapted to be less sensitive to menses-induced skin irritation than other anatomical sites.

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  • (PMID = 17040890.001).
  • [ISSN] 1556-9527
  • [Journal-full-title] Cutaneous and ocular toxicology
  • [ISO-abbreviation] Cutan Ocul Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Namazi MR, Maghsoodi M: Association of angiokeratoma of the vulva with angioma serpiginosum. J Drugs Dermatol; 2008 Sep;7(9):882-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of angiokeratoma of the vulva with angioma serpiginosum.
  • Angioma serpiginosum is a rare benign vascular disorder usually beginning in childhood.
  • Angiokeratoma of the vulva is an uncommon lesion occurring in older women.
  • [MeSH-major] Angiokeratoma / pathology. Hemangioma / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Buttocks / pathology. Female. Humans. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 19112804.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Bakken IJ, Bratt H, Skjeldestad FE, Nordbø SA: [Detection of chlamydia trachomatis in urine, vulval and cervical swabs]. Tidsskr Nor Laegeforen; 2005 Jun 16;125(12):1629-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection of chlamydia trachomatis in urine, vulval and cervical swabs].
  • [Transliterated title] Påvisning av Chlamydia trachomatis i urin-, vulva- og cervixprøver.
  • In this study, vulval swabs and urine are compared to conventional cervix samples.
  • MATERIALS AND METHODS: Vulval swabs, urine and cervix samples from 541 young, healthy women were tested for Chlamydia by polymerase chain reaction technique.
  • The sensitivity (cervix 22/22, urine 21/22 and vulva 21/22) and specificity (no false negative results) were high for all sampling sites.
  • INTERPRETATION: Urine samples or vulval swabs can replace conventional cervix swabs for the detection of Chlamydia.
  • [MeSH-major] Cervix Uteri / microbiology. Chlamydia trachomatis / isolation & purification. Urine / microbiology. Vulva / microbiology
  • [MeSH-minor] Adolescent. Adult. Chlamydia Infections / epidemiology. Chlamydia Infections / pathology. Chlamydia Infections / urine. Female. Humans. Norway / epidemiology. Polymerase Chain Reaction. Prevalence. Sensitivity and Specificity. Vaginal Smears

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  • (PMID = 15976824.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Norway
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36. Lucas EW Jr, Branton P, Mecklenburg FE, Moawad GN: Ectopic breast fibroadenoma of the vulva. Obstet Gynecol; 2009 Aug;114(2 Pt 2):460-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic breast fibroadenoma of the vulva.
  • BACKGROUND: Ectopic breast (extramammary) fibroadenomas of the vulva are rare, cosmetically disfiguring, and very difficult to distinguish from other labial masses on physical examination.
  • Extramammary tissue is susceptible to similar benign and malignant changes seen in the breast.
  • CASE: We report a case of a young woman who presented with an unknown progressively enlarging mass in the vulva.
  • CONCLUSION: Clinicians should include extramammary lesions in their preoperative differential diagnosis of vulvar masses since some may become neoplastic.
  • Treatment is complete excision and renal imaging should be considered after a confirmed histopathologic diagnosis.
  • [MeSH-major] Breast. Choristoma / pathology. Fibroadenoma / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 19622961.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Malliah R, Gilhooly P, Lambert WC, Heller DS: Sebaceous hyperplasia of the vulva: case report and review of the literature. J Low Genit Tract Dis; 2006 Jan;10(1):55-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous hyperplasia of the vulva: case report and review of the literature.
  • The occurrence of the lesion on the vulva is exceptionally rare.
  • We report a case of sebaceous hyperplasia of the vulva with an unusual presentation.
  • [MeSH-major] Sebaceous Glands / pathology. Vulva / pathology
  • [MeSH-minor] Administration, Topical. Biopsy. Clobetasol / administration & dosage. Clobetasol / analogs & derivatives. Clobetasol / therapeutic use. Diagnosis, Differential. Female. Humans. Hyperplasia / drug therapy. Hyperplasia / pathology. Middle Aged. Vasoconstrictor Agents / administration & dosage. Vasoconstrictor Agents / therapeutic use

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  • (PMID = 16378033.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasoconstrictor Agents; 9P6159HM7T / halobetasol; ADN79D536H / Clobetasol
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38. Schlager B, Röseler W, Zheng M, Gutierrez A, Sommer RJ: HAIRY-like transcription factors and the evolution of the nematode vulva equivalence group. Curr Biol; 2006 Jul 25;16(14):1386-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HAIRY-like transcription factors and the evolution of the nematode vulva equivalence group.
  • BACKGROUND: Nematode vulva formation provides a paradigm to study the evolution of pattern formation and cell-fate specification.
  • The Caenorhabditis elegans vulva is generated from three of six equipotent cells that form the so-called vulva equivalence group.
  • During evolution, the size of the vulva equivalence group has changed: Panagrellus redivivus has eight, C. elegans six, and Pristionchus pacificus only three cells that are competent to form vulval tissue.
  • In P. pacificus, programmed cell death of individual vulval precursor cells alters the size of the vulva equivalence group.
  • RESULTS: We have identified the genes controlling this cell-death event and the molecular mechanism of the reduction of the vulva equivalence group.
  • Mutations in Ppa-hairy, a gene that is unknown from C. elegans, result in the survival of two precursor cells, which expands the vulva equivalence group.
  • Ppa-HAIRY and Ppa-GROUCHO form a molecular module that represses the Hox gene Ppa-lin-39 and thereby reduces the size of the vulva equivalence group.
  • CONCLUSIONS: We conclude that the vulva equivalence group in Pristionchus is patterned by a HAIRY/GROUCHO module, which is absent in Caenorhabditis.
  • [MeSH-major] Basic Helix-Loop-Helix Transcription Factors / physiology. Biological Evolution. Helminth Proteins / physiology. Nematoda / growth & development. Repressor Proteins / physiology. Vulva / growth & development
  • [MeSH-minor] Amino Acid Sequence. Animals. Apoptosis. Base Sequence. Caenorhabditis elegans / cytology. Caenorhabditis elegans / growth & development. Caenorhabditis elegans / metabolism. Cell Differentiation / genetics. Female. Gene Expression Regulation, Developmental. Helix-Loop-Helix Motifs. Homeodomain Proteins / genetics. Homeodomain Proteins / metabolism. Molecular Sequence Data. Mutation. Protein Structure, Tertiary. Sequence Alignment

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  • [CommentIn] Curr Biol. 2006 Jul 25;16(14):R532-3 [16860726.001]
  • (PMID = 16860737.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Helminth Proteins; 0 / Homeodomain Proteins; 0 / Repressor Proteins
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39. Tian H, Schlager B, Xiao H, Sommer RJ: Wnt signaling induces vulva development in the nematode Pristionchus pacificus. Curr Biol; 2008 Jan 22;18(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Wnt signaling induces vulva development in the nematode Pristionchus pacificus.
  • The Caenorhabditis elegans vulva is induced by a member of the epidermal growth factor (EGF) family that is expressed in the gonadal anchor cell, representing a prime example of signaling processes in animal development.
  • Comparative studies indicated that vulva induction has changed rapidly during evolution.
  • By analyzing deletion mutants in five Wnt pathway genes, we show that Wnt signaling induces vulva formation in Pristionchus pacificus.
  • Several Wnt ligands and receptors act redundantly in vulva induction, and Ppa-egl-20/Wnt; Ppa-mom-2/Wnt; Ppa-lin-18/Ryk triple mutants are strongly vulvaless.
  • In contrast, previous studies indicated that Ppa-lin-17, one of the Frizzled-type receptors, has a negative role in vulva formation.
  • Thus, an unexpected complexity of Wnt signaling is involved in vulva induction and vulva repression in P. pacificus.
  • This study provides the first molecular identification of the inductive vulva signal in a nematode other than Caenorhabditis.
  • [MeSH-minor] Animals. Caenorhabditis elegans / growth & development. Caenorhabditis elegans / metabolism. Female. Signal Transduction / physiology. Vulva / growth & development

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  • (PMID = 18207741.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Wnt Proteins
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40. Goldstein AT, Anhalt GJ, Klingman D, Burrows LJ: Mucous membrane pemphigoid of the vulva. Obstet Gynecol; 2005 May;105(5 Pt 2):1188-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucous membrane pemphigoid of the vulva.
  • Blistering and scarring may occur in the eyes, mouth, esophagus, larynx, and on the vulva.
  • Scarring can result in severe structural changes to the vulva that may mimic the findings of other inflammatory dermatologic disorders of the vulva, including lichen sclerosus and lichen planus.
  • CASE: A 58-year-old woman presented with vulvar erosions, esophagitis, and laryngeal blisters.
  • The clinical picture and the histopathology of a vulvar biopsy were suggestive of erosive lichen planus.
  • CONCLUSION: This case illustrates the importance of examining extragenital mucosal surfaces of any woman presenting with vulvar lesions.
  • In addition, it demonstrates the importance of vulvar biopsy and the usefulness of direct immunofluorescence to differentiate between conditions with similar clinical and histopathologic changes.
  • [MeSH-major] Mycophenolic Acid / analogs & derivatives. Pemphigoid, Benign Mucous Membrane / diagnosis. Pemphigoid, Benign Mucous Membrane / drug therapy. Vulvar Diseases / diagnosis. Vulvar Diseases / drug therapy
  • [MeSH-minor] Biopsy, Needle. Drug Therapy, Combination. Female. Fluorescent Antibody Technique, Direct. Follow-Up Studies. Humans. Immunohistochemistry. Middle Aged. Prednisone / therapeutic use. Severity of Illness Index. Treatment Outcome

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  • (PMID = 15863576.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9242ECW6R0 / mycophenolate mofetil; HU9DX48N0T / Mycophenolic Acid; VB0R961HZT / Prednisone
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41. Yang CC, Cold CJ, Yilmaz U, Maravilla KR: Sexually responsive vascular tissue of the vulva. BJU Int; 2006 Apr;97(4):766-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sexually responsive vascular tissue of the vulva.
  • OBJECTIVE: To better understand the genital changes that occur during the female sexual response, using a gross anatomical and histological study of the vascular tissue of the vulva, supplemented with magnetic resonance imaging (MRI).
  • RESULTS: There are five vascular compartments of the female external genitalia, found in the clitoris, clitoral bulbs, labia minora, urethra, and vestibule/vagina.
  • CONCLUSIONS: The vulva contains a substantial amount of vascular tissue.
  • [MeSH-major] Arousal / physiology. Sexual Behavior / physiology. Vulva / anatomy & histology
  • [MeSH-minor] Female. Humans. Libido / physiology. Magnetic Resonance Imaging / methods

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  • [CommentIn] BJU Int. 2006 Aug;98(2):463-4 [16879696.001]
  • (PMID = 16536770.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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42. Schlosser BJ: Contact dermatitis of the vulva. Dermatol Clin; 2010 Oct;28(4):697-706

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contact dermatitis of the vulva.
  • Contact dermatitis of the vulva is common, with irritant contact dermatitis occurring more frequently than allergic contact dermatitis.
  • Patients with chronic vulvar dermatoses are at greater risk and should continually be reassessed for possible contact dermatitis.
  • Patient education and follow-up are essential in optimizing treatment and preventing recurrence of vulvar contact dermatitis.
  • [MeSH-major] Dermatitis, Allergic Contact / diagnosis. Dermatitis, Allergic Contact / drug therapy. Dermatitis, Irritant / diagnosis. Dermatitis, Irritant / drug therapy. Vulvitis / diagnosis. Vulvitis / drug therapy
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Anti-Infective Agents / therapeutic use. Estrogens / therapeutic use. Female. Histamine Antagonists / therapeutic use. Humans

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20883913.001).
  • [ISSN] 1558-0520
  • [Journal-full-title] Dermatologic clinics
  • [ISO-abbreviation] Dermatol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Anti-Infective Agents; 0 / Estrogens; 0 / Histamine Antagonists
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43. Gagné HM: Colposcopy of the vagina and vulva. Obstet Gynecol Clin North Am; 2008 Dec;35(4):659-69; x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colposcopy of the vagina and vulva.
  • Colposcopic evaluation of the vagina and vulva is an important adjunct to cervical colposcopy because human papillomavirus disease can be multifocal and multicentric.
  • Other reasons for vulvar and vaginal colposcopy include cytology unexplained by cervical findings, vaginal and vulvar symptoms, and diethylstilbestrol exposure.
  • Vaginal and vulvar intraepithelial neoplastic lesions are important cancer precursors to evaluate and treat.
  • [MeSH-major] Colposcopy / methods. Papillomavirus Infections / diagnosis. Vagina / cytology. Vaginal Diseases / diagnosis. Vulva / cytology. Vulvar Diseases / diagnosis
  • [MeSH-minor] Biopsy. Female. Humans. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / pathology. Vulvar Neoplasms / diagnosis. Vulvar Neoplasms / pathology

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  • (PMID = 19061824.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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44. Baron M, Hitzel A, Sartor A, d'Anjou J, Dessogne P: [Paget's disease of the vulva: interest of sentinel lymph node analysis]. Gynecol Obstet Fertil; 2006 Jul-Aug;34(7-8):619-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Paget's disease of the vulva: interest of sentinel lymph node analysis].
  • [Transliterated title] Maladie de Paget de la vulve: intérêt de l'étude du ganglion sentinelle.
  • Paget's disease of the vulva is difficult to diagnose, as far as the extent of this lesion is concerned, since it is often coupled with invasive adenocarcinoma of the vulva.
  • Thus, we present two cases of Paget's disease of the vulva, with use of sentinel lymph node analysis- a non-validated technique in this very context.
  • [MeSH-major] Paget Disease, Extramammary / diagnosis. Sentinel Lymph Node Biopsy. Vulvar Diseases / diagnosis
  • [MeSH-minor] Adenocarcinoma / complications. Aged. Diagnosis, Differential. Female. Humans. Vulvar Neoplasms / complications

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  • (PMID = 16854611.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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45. Mharrech A, Benchakroun N, Tawfiq N, Jouhadi H, Acharki A, Sahraoui S, Benider A: [Small-cell carcinoma of the vulva]. J Gynecol Obstet Biol Reprod (Paris); 2006 Dec;35(8 Pt 1):834-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Small-cell carcinoma of the vulva].
  • [Transliterated title] Le carcinome à petites cellules de la vulve: à propos d'un cas avec revue de la littérature.
  • Small-cell carcinoma is a rare and aggressive malignancy; this tumor is lethal due to the propensity to metastasize early in the course of the disease.
  • Small-cell cancer also rarely may occur in the female genital tract, usually in the cervix.
  • This article concerns the fifth reported case of small-cell carcinoma of the vulva in a 34-year-old women who had developed a vulvar mass3 months earlier.
  • Small-cell carcinoma of the vulva is a very rare tumor.
  • Similarly to small-cell cancers arising in other sites, it appears that regional therapy is not a sufficient treatment for this tumor.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / surgery. Vulvar Neoplasms / drug therapy. Vulvar Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Fatal Outcome. Female. Humans. Lymph Node Excision

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  • (PMID = 17151543.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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46. Hwang C, Kim YJ, Seo YJ, Park JK, Lee JH, Lee Y: Isolated Langerhans cell histiocytosis of the vulva in an infant. Pediatr Dermatol; 2009 Nov-Dec;26(6):751-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated Langerhans cell histiocytosis of the vulva in an infant.
  • Langerhans cell histiocytosis affecting only the vulva of a child is very rare.
  • We report a 1-year-old female infant with isolated Langerhans cell histiocytosis presenting as pruritic papules confined to the vulva, confirmed by histopathology with immunohistochemical staining.
  • [MeSH-major] Histiocytosis, Langerhans-Cell / pathology. Skin Diseases / pathology. Vulva / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Biopsy. Dermis / pathology. Female. Humans. Infant


47. Thomas M, George R, Thomas M: Linear epidermolytic acanthoma of vulva: an unusual presentation. Indian J Dermatol Venereol Leprol; 2010 Jan-Feb;76(1):49-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linear epidermolytic acanthoma of vulva: an unusual presentation.
  • Epidermolytic acanthoma (EA) is a rare benign tumor that shows epidermolytic hyperkeratosis (EH) on histopathology.
  • We diagnosed an unusual case of EA of the vulva presenting in a linear pattern in a 50-year-old lady based on the clinical features and typical histopathological findings and stress the importance of considering epidermolytic acanthoma in the differential diagnosis of verrucous lesions of the genitalia.
  • [MeSH-major] Acanthoma / diagnosis. Skin Neoplasms / diagnosis. Vulvar Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • [CommentIn] Indian J Dermatol Venereol Leprol. 2010 Sep-Oct;76(5):563; author reply 563-4 [20827001.001]
  • (PMID = 20061731.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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48. Georgantopoulou C, Aird I: Management of myoepithelioma of the vulva--case report and review of the literature. Eur J Gynaecol Oncol; 2009;30(2):203-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of myoepithelioma of the vulva--case report and review of the literature.
  • Myoepithelioma of the vulva is a rare condition, with only three cases having been reported so far.
  • We present our case together with a review of all relevant literature in order to collect and summarise the experience accrued so far, and draw conclusions regarding the management of these myoepitheliomas when they appear on the vulva.
  • It seems that vulval myoepitheliomas can be of low- or high-grade malignancy and that the grade, which determines the prognosis, should be the main factor to consider when planning the management.
  • We also conclude that the clinical behaviour of these tumours of the vulva most probably follow the course of the myoepitheliomas that affect the soft tissues in general.
  • [MeSH-minor] Adult. Female. Humans. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery

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  • (PMID = 19480256.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 9
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49. Zheng M, Messerschmidt D, Jungblut B, Sommer RJ: Conservation and diversification of Wnt signaling function during the evolution of nematode vulva development. Nat Genet; 2005 Mar;37(3):300-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservation and diversification of Wnt signaling function during the evolution of nematode vulva development.
  • Cell-fate specification and cell-cell signaling have been well studied during vulva development in Caenorhabditis elegans and provide a paradigm in evolutionary developmental biology.
  • A common aspect of vulva formation in both species is the polarization of the P7.p lineage, which is responsible for vulval symmetry.
  • In C. elegans, Wnt signaling is crucial for P7.p cell-fate patterning; nothing is known about vulval symmetry in P. pacificus.
  • In addition, mutations in Ppa-lin-17 (encoding Frizzled) and morpholino knock-down of Ppa-lin-44 (encoding Wnt), Ppa-egl-20 (encoding Wnt), Ppa-mig-5 (encoding Dsh), Ppa-apr-1 (encoding APC) and Ppa-bar-1 (encoding beta-catenin) results in gonad-independent vulva differentiation, indicating that these genes have a role in a negative signaling process.
  • In contrast, in C. elegans, Wnt signaling has a positive role in vulva induction, and mutations in bar-1 result in a hypoinduced phenotype.
  • Therefore, whereas the molecular mechanisms that generate vulval symmetry are conserved, the genetic control of vulva induction diversified during evolution.
  • [MeSH-major] Caenorhabditis elegans / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Signal Transduction. Vulva / growth & development
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Female. Membrane Proteins / chemistry. Membrane Proteins / genetics. Molecular Sequence Data. Sequence Homology, Amino Acid. Wnt Proteins

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  • (PMID = 15696167.001).
  • [ISSN] 1061-4036
  • [Journal-full-title] Nature genetics
  • [ISO-abbreviation] Nat. Genet.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AY562975
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Wnt Proteins
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50. Sadownik LA, Crawford RI: Post-surgical treatment of melanoma in situ of the vulva with imiquimod. J Obstet Gynaecol Can; 2010 Aug;32(8):771-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-surgical treatment of melanoma in situ of the vulva with imiquimod.
  • BACKGROUND: Melanoma in situ is a rare malignant lesion of the vulva.
  • CASE: We describe a case of melanoma in situ of the vulva in a 72-year-old woman that reoccurred after surgical excision and was treated successfully with topical 5% imiquimod.
  • CONCLUSION: There may be a role for imiquimod in treating melanoma in situ of the vulva.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Melanoma / drug therapy. Melanoma / surgery. Vulvar Neoplasms / drug therapy. Vulvar Neoplasms / surgery
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans

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  • (PMID = 21050510.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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51. El Demellawy D, Saleh R, Daya D, Alowami S: Malignant giant cell tumor of the vulva. Int J Gynecol Pathol; 2010 Jan;29(1):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant giant cell tumor of the vulva.
  • Giant cell malignant fibrous histiocytoma or giant cell tumor of the soft parts (GCTSP) is a rare soft tissue tumor.
  • GCTSP has an unpredictable behavior; the majority of the reported cases showed benign histology and those that showed malignant morphologic features were extremely rare.
  • To the best of our knowledge, GCTSP has never been reported to involve the vulva in the English literature.
  • We report the first case of malignant GCTSP of the vulva.
  • Histologic features and the immunoprofile of the tumor and differential diagnosis are discussed in detail.
  • Although extremely rare, consideration of the potential occurrence of GCTSP in the vulva is recommended to avoid a potential diagnostic pitfall.
  • [MeSH-major] Giant Cell Tumors / secondary. Neoplasm Recurrence, Local / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Fatal Outcome. Female. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Lymphatic Metastasis / pathology

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  • (PMID = 19952930.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Levavi H, Sabah G, Kaplan B, Tytiun Y, Braslavsky D, Gutman H: Granular cell tumor of the vulva: six new cases. Arch Gynecol Obstet; 2006 Jan;273(4):246-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the vulva: six new cases.
  • Five to sixteen percent occur in the vulva.
  • We present our experience with granular cell tumors of the vulva in six patients, all of whom had wide local excisions and were followed-up in our outpatient clinic for 3-171 months.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Foot Diseases / surgery. Humans. Middle Aged. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery. Toes / surgery

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  • (PMID = 16133461.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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53. Khunger N: Combination technique of radiofrequency ablation with sclerotherapy in acquired lymphangiectasis of the vulva. J Cutan Aesthet Surg; 2009 Jan;2(1):33-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combination technique of radiofrequency ablation with sclerotherapy in acquired lymphangiectasis of the vulva.
  • Aquired lymphangiectasis of the vulva is an uncommon condition and only few cases have been reported following tuberculous lymphadenitis.

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  • [Cites] Int J Dermatol. 1979 Jan-Feb;18(1):65-6 [761961.001]
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  • (PMID = 20300370.001).
  • [ISSN] 0974-5157
  • [Journal-full-title] Journal of cutaneous and aesthetic surgery
  • [ISO-abbreviation] J Cutan Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2840920
  • [Keywords] NOTNLM ; Radiofrequency ablation / sclerotherapy / vulvar lymphangiectasis
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54. Chang SE, Lee DK, Choi JH, Moon KC, Koh JK: Majocchi's granuloma of the vulva caused by Trichophyton mentagrophytes. Mycoses; 2005 Nov;48(6):382-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Majocchi's granuloma of the vulva caused by Trichophyton mentagrophytes.
  • We report a case of Majocchi's granuloma caused by Trichophyton mentagrophytes on the vulva in a 23-year-old girl who had used topical steroids for many years.
  • [MeSH-major] Granuloma / microbiology. Tinea / microbiology. Trichophyton / isolation & purification. Vulva / microbiology. Vulvar Diseases / microbiology
  • [MeSH-minor] Adult. Antifungal Agents / therapeutic use. Female. Humans. Itraconazole / therapeutic use

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  • (PMID = 16262873.001).
  • [ISSN] 0933-7407
  • [Journal-full-title] Mycoses
  • [ISO-abbreviation] Mycoses
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antifungal Agents; 304NUG5GF4 / Itraconazole
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55. Moodley M, Jordaan A: Ewing's sarcoma of the vulva--a case report. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1177-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ewing's sarcoma of the vulva--a case report.
  • Extraosseous Ewing's sarcoma of the vulva is extremely rare with only three such cases described.
  • A 26-year-old woman presented with Ewing's sarcoma of the vulva.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Lung Neoplasms / therapy. Sarcoma, Ewing / therapy. Vulvar Neoplasms / therapy
  • [MeSH-minor] Adult. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Female. Humans. Ifosfamide / administration & dosage. Radiotherapy. Vincristine / administration & dosage

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  • (PMID = 16343207.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; UM20QQM95Y / Ifosfamide
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56. Vignes S, Arrault M, Trévidic P: Surgical resection of vulva lymphoedema circumscriptum. J Plast Reconstr Aesthet Surg; 2010 Nov;63(11):1883-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical resection of vulva lymphoedema circumscriptum.
  • BACKGROUND: Lymphangioma circumscriptum, a rare, benign disease that can be either congenital or acquired, involves the deep dermis and subcutaneous lymphatics.
  • OBJECTIVE: This study aims to analyse the efficacy of surgical resection of vulva lymphangioma circumscriptum (VLC).
  • [MeSH-major] Gynecologic Surgical Procedures / methods. Lymphangiectasis / surgery. Lymphangioma / surgery. Vulvar Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Middle Aged. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20004630.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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57. Fong YE, López-Terrada D, Zhai QJ: Primary Ewing sarcoma/peripheral primitive neuroectodermal tumor of the vulva. Hum Pathol; 2008 Oct;39(10):1535-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Ewing sarcoma/peripheral primitive neuroectodermal tumor of the vulva.
  • We report a case of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) arising in the vulva in a 17-year-old adolescent girl.
  • Primary extraskeletal ES/pPNET is uncommon and only rarely affects the female genital tract.
  • This report described another very rare case of ES/pPNET arising in the vulva and confirmed by molecular analysis.
  • [MeSH-major] Neuroectodermal Tumors, Primitive, Peripheral / pathology. Sarcoma, Ewing / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adolescent. Base Sequence. Biomarkers, Tumor. DNA, Neoplasm / analysis. Female. Glycogen / metabolism. Humans. Molecular Sequence Data. Neoplasms, Multiple Primary. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Periodic Acid-Schiff Reaction. Proto-Oncogene Protein c-fli-1. RNA-Binding Protein EWS. Sequence Analysis, DNA. Transcription Factors / genetics. Transcription Factors / metabolism

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  • (PMID = 18602673.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS; 0 / Transcription Factors; 9005-79-2 / Glycogen
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58. Gerszten K, Selvaraj RN, Kelley J, Faul C: Preoperative chemoradiation for locally advanced carcinoma of the vulva. Gynecol Oncol; 2005 Dec;99(3):640-4
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative chemoradiation for locally advanced carcinoma of the vulva.
  • OBJECTIVE: A twice daily (BID) radiation treatment schedule (interval of 4-6 h) delivered concurrent with chemotherapy for advanced or critically located carcinoma of the vulva was modeled on the schema developed by the Gynecology Oncology Group (GOG).
  • METHODS: A retrospective review was conducted of the records of 18 patients with vulvar cancer.
  • The regional nodes and primary tumor were prescribed 44.6 Gy.
  • Resection of the primary tumor bed and inguinal dissection was planned at 4-6 weeks post-treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / therapy. Vulvar Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cisplatin / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Middle Aged. Neoadjuvant Therapy. Preoperative Care. Retrospective Studies. Treatment Outcome

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  • (PMID = 16169579.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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59. Venizelos ID, Mandala E, Tatsiou ZA, Acholos V, Goutzioulis M: Primary langerhans cell histiocytosis of the vulva. Int J Gynecol Pathol; 2006 Jan;25(1):48-51
MedlinePlus Health Information. consumer health - Vulvar Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary langerhans cell histiocytosis of the vulva.
  • Langerhans cell histiocytosis (LCH) of the female genital tract is very rare.
  • A review of the literature revealed that only 12 cases of primary vulvar LCH have previously been published.
  • We describe an additional case of LCH in which the disease was confined to the vulva.
  • On histological and immunohistochemical examination, the tumor fulfilled the criteria of LCH.
  • A metastatic workup did not reveal any evidence of disease beyond the vulva.
  • [MeSH-major] Histiocytosis, Langerhans-Cell / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Antigens, CD1 / metabolism. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Female. Humans. Middle Aged. Radiotherapy, Adjuvant. S100 Proteins / metabolism. Treatment Outcome

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  • (PMID = 16306784.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Biomarkers, Tumor; 0 / CD1a antigen; 0 / S100 Proteins
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60. Jianhong L, Xuewu J, Xianliang H: An exceptional combined malformation: duplication of the urinary and intestinal tracts and the vulva (04-80CR). J Pediatr Surg; 2005 Mar;40(3):E5-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An exceptional combined malformation: duplication of the urinary and intestinal tracts and the vulva (04-80CR).
  • The authors reported the surgical treatment of a 2-year-old girl with complete duplication of the kidney, ureter, bladder, urethra, and the vulva, associated with intestinal duplication and complete duplication of the appendix and colon.
  • After a series of preoperative examinations, exploratory operation including reduction of intestinal malrotation, fusion of bladder and colon, obliteration of the duplicated urethra, resection of the intestinal and appendiceal duplications, and cosmetic repair of the vulva was performed.
  • [MeSH-major] Abnormalities, Multiple / pathology. Intestines / abnormalities. Urinary Tract / abnormalities. Vulva / abnormalities
  • [MeSH-minor] Anal Canal / abnormalities. Anal Canal / surgery. Appendectomy. Appendix / abnormalities. Child, Preschool. Colon / abnormalities. Colon / surgery. Female. Humans. Kidney / abnormalities. Nephrectomy. Torsion Abnormality / congenital. Torsion Abnormality / surgery. Ureter / abnormalities. Ureter / surgery. Urinary Bladder / abnormalities. Urinary Bladder / surgery

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  • (PMID = 15793715.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Dash S, Verghese J, Nizami DJ, Awasthi RT, Jaishi S, Sunil M: Severe haematoma of the vulva--a report of two cases and a clinical review. Kathmandu Univ Med J (KUMJ); 2006 Apr-Jun;4(2):228-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Severe haematoma of the vulva--a report of two cases and a clinical review.
  • Haematoma of the vulva may occur following blunt trauma due to its highly vascular structure.
  • We present two cases of haematoma of the vulva caused by domestic violence, following a kick on the perineum and falling astride on the perineum.
  • [MeSH-major] Hematoma / surgery. Vulva / injuries. Wounds, Nonpenetrating / surgery
  • [MeSH-minor] Adolescent. Adult. Domestic Violence. Female. Humans

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  • (PMID = 18603903.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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62. Mehta V, Balachandran C, Rao L, Geeta V: Giant granular cell tumor of the vulva. Indian J Dermatol Venereol Leprol; 2010 May-Jun;76(3):263-5
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant granular cell tumor of the vulva.
  • A 55-year-old lady presented with a large skin colored growth on her vulva since the age of 15 years, which gradually increased to the present state, with the development of a new lesion on her left thigh.
  • Biopsy followed by immunohistochemistry showed features consistent with a granular cell tumor.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Middle Aged

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  • (PMID = 20445297.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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63. Hoque SR, Patel M, Farrell AM: Childhood cicatricial pemphigoid confined to the vulva. Clin Exp Dermatol; 2006 Jan;31(1):63-4
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  • [Title] Childhood cicatricial pemphigoid confined to the vulva.
  • Cicatricial pemphigoid or benign mucous membrane pemphigoid is an autoimmune bullous disease predominantly affecting the mucosal surfaces and healing with scar formation.
  • Localized cicatricial pemphigoid of the vulva in children is rare.
  • [MeSH-major] Pemphigoid, Benign Mucous Membrane / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Administration, Topical. Anti-Inflammatory Agents / administration & dosage. Betamethasone Valerate / administration & dosage. Child. Clobetasol / administration & dosage. Clobetasol / analogs & derivatives. Female. Humans. Treatment Outcome

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  • (PMID = 16309485.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 9IFA5XM7R2 / Betamethasone Valerate; ADN79D536H / Clobetasol
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64. Zauner H, Sommer RJ: Evolution of robustness in the signaling network of Pristionchus vulva development. Proc Natl Acad Sci U S A; 2007 Jun 12;104(24):10086-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolution of robustness in the signaling network of Pristionchus vulva development.
  • One system in which such microevolutionary studies can be performed is vulva development in the nematode Pristionchus pacificus.
  • Three vulval precursor cells respond to redundant cell-cell interactions, including signals from the gonad and the epidermal cell P8.p.
  • Interestingly, P. pacificus P8.p is involved in cell fate specification of the future vulva cells by lateral inhibition but is incompetent to respond to the inductive signal from the gonad itself.
  • We show that vulva misspecification events differ between Pristionchus strains and species.
  • Surprisingly, in some recombinant inbred lines of two distinct P. pacificus isolates, P8.p gained competence to form vulva tissue, a trait that was never observed in P. pacificus isolates.
  • [MeSH-major] Evolution, Molecular. Nematoda / embryology. Signal Transduction. Vulva / embryology
  • [MeSH-minor] Animals. Cell Lineage. Embryo, Nonmammalian. Female. Inbreeding. Models, Biological. Recombination, Genetic. Species Specificity

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  • [Cites] Development. 2000 Aug;127(15):3295-303 [10887085.001]
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  • (PMID = 17551021.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1891216
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65. Vaupel P, Mayer A, Höckel M: Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva. Eur J Gynaecol Oncol; 2006;27(2):142-6
Hazardous Substances Data Bank. OXYGEN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva.
  • INTRODUCTION: Cancers of the vulva are relatively rare and, therefore, little is known about the pathophysiological role of tumor oxygenation in this entity.
  • METHODS: Data are presented on the oxygenation status of primary (n = 15) and recurrent (n = 19) cancers of the vulva, as measured by the Eppendorf pO2 histography system.
  • RESULTS: Contrary to other tumor entities, no significant differences in the oxygenation status between primary (median pO2 = 13 mmHg; hypoxic fraction < or = 5 mmHg = 37%) and recurrent (median pO2 = 11 mmHg; hypoxic fraction < or = 5 mmHg = 45%) tumors were found.
  • Oxygenation was significantly lower in cancers of the vulva than in the subcutis.
  • Anemic patients had significantly poorer tumor oxygenation compared with patients whose cHb values were within the normal range (p = 0.02).
  • CONCLUSIONS: The oxygenation of vulvar cancers is similar to other tumor entities, but does not show more severe hypoxia in recurrent cases.
  • Anemia is associated with a poorer oxygenation status in vulvar cancers, whereas in the normal tissue no impact of cHb values on the median pO2 was observed.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Neoplasm Recurrence, Local / metabolism. Oxygen / metabolism. Oxygen Consumption. Vulvar Neoplasms / metabolism
  • [MeSH-minor] Anemia. Cell Hypoxia. Female. Humans

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  • (PMID = 16620056.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] S88TT14065 / Oxygen
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66. Kim JH, Choi YS, Lee TS: A case of epithelioid sarcoma arising in the vulva. J Gynecol Oncol; 2008 Sep;19(3):202-4

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  • [Title] A case of epithelioid sarcoma arising in the vulva.
  • Epithelioid sarcoma of vulva is extremely rare.
  • Early diagnosis is difficult because of its benign appearance as a painless subcutaneous nodule.
  • We report a case of epithelioid sarcoma that occurred in the left vulva with a brief review of literature.

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  • (PMID = 19471567.001).
  • [ISSN] 2005-0380
  • [Journal-full-title] Journal of gynecologic oncology
  • [ISO-abbreviation] J Gynecol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2676464
  • [Keywords] NOTNLM ; Epithelioid sarcoma / Treatment / Vulva
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67. Kiontke K, Barrière A, Kolotuev I, Podbilewicz B, Sommer R, Fitch DH, Félix MA: Trends, stasis, and drift in the evolution of nematode vulva development. Curr Biol; 2007 Nov 20;17(22):1925-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends, stasis, and drift in the evolution of nematode vulva development.
  • As a model, we used the nematode vulva, a highly conserved, essential organ, the development of which has been intensively studied in the model systems Caenorhabditis elegans and Pristionchus pacificus.
  • RESULTS: For 51 rhabditid species, we analyzed more than 40 characteristics of vulva development, including cell fates, fate induction, cell competence, division patterns, morphogenesis, and related aspects of gonad development.
  • This taxon-dense phylogeny provides for the first time a highly resolved picture of rhabditid evolution and allows the reconstruction of the number and directionality of changes in the vulva development characters.
  • [MeSH-major] Biological Evolution. Caenorhabditis elegans / embryology. Genetic Drift. Vulva / embryology
  • [MeSH-minor] Animals. Female. Phylogeny


68. Hatch KD, Davis JR: Complete resolution of Paget disease of the vulva with imiquimod cream. J Low Genit Tract Dis; 2008 Apr;12(2):90-4
Hazardous Substances Data Bank. Imiquimod .

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  • [Title] Complete resolution of Paget disease of the vulva with imiquimod cream.
  • We report on 2 women with vulva EMPD who achieved biopsy-confirmed resolution of their disease after topical application of imiquimod 5% cream.
  • [MeSH-major] Aminoquinolines / administration & dosage. Antineoplastic Agents / administration & dosage. Paget Disease, Extramammary / drug therapy. Vulvar Neoplasms / drug therapy
  • [MeSH-minor] Administration, Topical. Aged. Biopsy. Female. Follow-Up Studies. Humans. Male. Ointments. Vaginal Creams, Foams, and Jellies

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  • (PMID = 18369301.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Ointments; 0 / Vaginal Creams, Foams, and Jellies; 99011-02-6 / imiquimod
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69. Giger OT, Lacoste E, Honegger C, Padberg B, Moch H, Varga Z: Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva. Virchows Arch; 2007 Apr;450(4):471-4
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva.
  • We describe a phyllodes tumor of borderline malignancy in the labium majus of a 49-year-old woman.
  • The histogenetic origin of phyllodes tumors in the vulva is controversial.
  • Strong immunoreactivity for NY-BR-1, a novel breast differentiation antigen, was demonstrated within the epithelial components of the phyllodes tumor.
  • A similar expression pattern was observed in mammary-like glands of the vulva.
  • These findings provide further evidence that phyllodes tumors of the vulva might derive from mammary-like glands in the labium majus or from ectopic breast tissue.
  • [MeSH-major] Antigens, Neoplasm / analysis. Breast. Choristoma / pathology. Phyllodes Tumor / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 17318573.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / breast cancer antigen NY-BR-1, human
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70. Tran TA, Carlson JA: Plasmacytoid squamous cell carcinoma of the vulva. Int J Gynecol Pathol; 2008 Oct;27(4):601-5
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  • [Title] Plasmacytoid squamous cell carcinoma of the vulva.
  • Although neoplastic cells with a plasmacytoid appearance have been reported in a variety of tumors, to the best of our knowledge, a plasmacytoid squamous cell carcinoma (SCC) of the vulva or skin has heretofore not been described.
  • We document the case of a 92-year-old female patient with a history of multiple excisions for vulvar verrucous and SCCs, who presented with a 3-cm, symptomatic, polypoid mass of the left upper vulva.
  • Based on the tumor location, morphology, and immunohistochemical results, the diagnosis of plasmacytoid SCC of the vulva was rendered.
  • Like other plasmacytoid malignancies, vulvar plasmacytoid SCC is a rare and likely aggressive variant of SCC, which can pose significant diagnostic challenges.
  • Squamous cell carcinoma should also be considered in the differential diagnosis of neoplasms with plasmacytoid cytology.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Fatal Outcome. Female. Humans. Immunohistochemistry

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  • (PMID = 18753957.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Kolotuev I, Podbilewicz B: Changing of the cell division axes drives vulva evolution in nematodes. Dev Biol; 2008 Jan 1;313(1):142-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changing of the cell division axes drives vulva evolution in nematodes.
  • Vulval epithelial tubes invaginate through concerted cell migration, ring formation, stacking of rings and intra-ring cell fusion in the nematodes Caenorhabditis elegans, Oscheius tipulae and Pristionchus pacificus.
  • We hypothesize that each ring is formed from pairs of symmetrically positioned primordial vulval cells following three premises: If the final cell division is left-right, the daughters will fuse, migrate and form only one ring.
  • We test the ring hypothesis and found coincidence between the patterns of vulva cell divisions and the number of rings for 12 species.
  • We find heterochronic variations in the timing of division, migration and fusion of the vulval cells between species.
  • We report a unique ring-independent pathway of vulva formation in Panagrellus redivivus. C. elegans lin-11(n389) mutation results in cell fate transformations including changes in the orientation of vulval cell division. lin-11 animals have an additional ring, as predicted by the ring hypothesis.
  • We propose that the genetic pathway determining how vulval cells invaginate evolves through ring-dependent and ring-independent mechanisms.
  • [MeSH-minor] Animals. Cell Division. Female. Vulva / cytology. Vulva / embryology

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  • (PMID = 18031720.001).
  • [ISSN] 1095-564X
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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72. Stephen JK, Chen KM, Raitanen M, Grénman S, Worsham MJ: DNA hypermethylation profiles in squamous cell carcinoma of the vulva. Int J Gynecol Pathol; 2009 Jan;28(1):63-75
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  • [Title] DNA hypermethylation profiles in squamous cell carcinoma of the vulva.
  • In this study, we examined the contribution of aberrant methylation of promoter regions in methylation-prone tumor suppressors to the pathogenesis of vulvar cancer.
  • Thirteen cell lines from 12 patients with squamous cell carcinoma of the vulva were evaluated for aberrant methylation status and gene copy number alterations, concomitantly, using the methylation-specific multiplex ligation-dependent probe amplification assay.
  • Of the 22 tumor suppressor genes examined, aberrant methylation was observed for 9 genes: tumor protein p73 (TP73), fragile histidine triad (FHIT), von Hippel-Lindau (VHL), adenomatosis polyposis coli (APC), estrogen receptor 1 (ESR1), cyclin-dependent kinase inhibitor 2B (CDKN2B), death-associated protein kinase 1 (DAPK1), glutathione S-transferase pi (GSTP1), and immunoglobin superfamily, member 4 (IGSF4).
  • Frequent genetic alterations of loss and gain of gene copy number included gain of GSTP1 and multiple endocrine neoplasia type 1 (MEN1), and loss of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) and IGSF4 in over 50% of the squamous cell carcinoma of the vulva cell lines.
  • These findings underscore the contribution of both genetic and epigenetic events to the underlying pathogenesis of squamous cell carcinoma of the vulva.

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  • (PMID = 19047905.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE015990; United States / NIDCR NIH HHS / DE / R01 DE015990-05; United States / NIDCR NIH HHS / DE / DE 15990
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS52427; NLM/ PMC2605778
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73. Kato H, Kanematsu M, Sato E, Ito N, Furui T, Hirose Y: Magnetic resonance imaging findings of fibroepithelial polyp of the vulva: radiological-pathological correlation. Jpn J Radiol; 2010 Oct;28(8):609-12
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging findings of fibroepithelial polyp of the vulva: radiological-pathological correlation.
  • We describe the magnetic resonance (MR) imaging findings in a 20-year-old woman with a fibroepithelial polyp of the vulva.
  • Although the MRI findings of fibroepithelial polyps of the vulva are often similar to those of aggressive angiomyxoma, angiomyofibroblastoma, and cellular angiofibroma, a fibroepithelial polyp should be considered when radiological images demonstrate the following features: stratiform hypointense areas surrounded by patchy hyperintense areas on T2-weighted MRI and hyperintense areas on T1-weighted MRI.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neoplasms, Fibroepithelial / diagnosis. Polyps / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Young Adult

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  • (PMID = 20972861.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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74. Ninomiya R, Kishi K, Imanishi N, Nakajima H, Nakajima T: Reconstruction of vulva using pudendal thigh gluteal fold bilobed flap. J Plast Reconstr Aesthet Surg; 2010 Feb;63(2):e130-2
MedlinePlus Health Information. consumer health - Vaginal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of vulva using pudendal thigh gluteal fold bilobed flap.
  • In reconstructing a large defect of the vulva, we combined the gluteal fold and the pudendal thigh flaps and made a bilobed flap.
  • Thus, the gluteal fold pudendal thigh bilobed flap seems to be ideal for reconstructing large vulvar defects.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps. Vaginal Neoplasms / surgery. Vulva / surgery
  • [MeSH-minor] Adult. Buttocks / surgery. Female. Humans

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  • [Copyright] 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19595655.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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75. Buljan M, Poduje S, Situm M, Bulat V, Bolanča Z, Tomas D: Multiple angiokeratomas of the vulva: case report and literature review. Acta Dermatovenerol Croat; 2010;18(4):271-5
MedlinePlus Health Information. consumer health - Vulvar Cancer.

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  • [Title] Multiple angiokeratomas of the vulva: case report and literature review.
  • Angiokeratomas of the vulva are relatively rare finding and a limited number of cases have been reported in the literature.
  • Clinically, angiokeratomas of the vulva are benign vascular lesions usually occurring in middle-aged or older women.
  • Histopathologic analysis of the lesion confirmed the diagnosis of angiokeratoma, and all lesions were electrocauterized under local anesthesia.
  • [MeSH-major] Angiokeratoma / diagnosis. Skin Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Dermis / pathology. Electrocoagulation. Female. Humans. Middle Aged

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  • (PMID = 21251446.001).
  • [ISSN] 1847-6538
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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76. Narendra H, Ray S, Rao L, Geetha V: Malignant extrarenal rhabdoid tumor of the vulva in an adult. J Cancer Res Ther; 2010 Jan-Mar;6(1):82-5
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant extrarenal rhabdoid tumor of the vulva in an adult.
  • Sarcomas of the vulva account for only 1-3% of all vulvar malignancies.
  • Most common vulvar sarcomas are leiomyosarcomas, malignant fibrohistiocytomas, and aggressive angiomyxomas.
  • Malignant rhabdoid tumor (MRT) of the kidney is a distinctive clinicopathological entity that is recognized as a highly aggressive renal tumor of childhood.
  • MRT of the vulva is a rare and very aggressive neoplasm.
  • [MeSH-major] Rhabdoid Tumor / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Female. Gynecologic Surgical Procedures. Humans. Middle Aged. Radiotherapy, Adjuvant

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  • (PMID = 20479553.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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77. Brown CJ, Wong M, Davis CC, Kanti A, Zhou X, Forney LJ: Preliminary characterization of the normal microbiota of the human vulva using cultivation-independent methods. J Med Microbiol; 2007 Feb;56(Pt 2):271-6
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  • [Title] Preliminary characterization of the normal microbiota of the human vulva using cultivation-independent methods.
  • The objective of this study was to perform a preliminary characterization of the microbial populations of the normal human vulva.
  • Even among this limited number of individuals, the microbiota of the human vulva was found to be quite diverse.
  • The results indicated that the microbiota of the vulva includes populations known to be commensals of the microbiota of the skin, colon and vagina, and is much more complex than previously thought, suggesting that more extensive investigations are warranted.
  • [MeSH-major] Bacteria / classification. Bacteria / isolation & purification. Vulva / microbiology
  • [MeSH-minor] Adult. Biodiversity. DNA, Bacterial / chemistry. DNA, Bacterial / genetics. DNA, Ribosomal / chemistry. DNA, Ribosomal / genetics. Female. Humans. Molecular Sequence Data. Phylogeny. RNA, Ribosomal, 16S / genetics. Sequence Analysis, DNA

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  • (PMID = 17244812.001).
  • [ISSN] 0022-2615
  • [Journal-full-title] Journal of medical microbiology
  • [ISO-abbreviation] J. Med. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ DQ975475/ DQ975476/ DQ975477/ DQ975478/ DQ975479/ DQ975480/ DQ975481/ DQ975482/ DQ975483/ DQ975484/ DQ975485/ DQ975486/ DQ975487/ DQ975488/ DQ975489/ DQ975490/ DQ975491/ DQ975492/ DQ975493/ DQ975494/ DQ975495/ DQ975496/ DQ975497/ DQ975498/ DQ975499/ DQ975500/ DQ975501/ DQ975502/ DQ975503/ DQ975504/ DQ975505/ DQ975506/ DQ975507/ DQ975508/ DQ975509/ DQ975510/ DQ975511/ DQ975512/ DQ975513/ DQ975514/ DQ975515/ DQ975516/ DQ975517/ DQ975518/ DQ975519/ DQ975520/ DQ975521/ DQ975522/ DQ975523/ DQ975524/ DQ975525/ DQ975526/ DQ975527/ DQ975528/ DQ975529/ DQ975530/ DQ975531/ DQ975532/ DQ975533/ DQ975534/ DQ975535/ DQ975536/ DQ975537/ DQ975538/ DQ975539/ DQ975540/ DQ975541/ DQ975542/ DQ975543/ DQ975544/ DQ975545/ DQ975546/ DQ975547/ DQ975548/ DQ975549/ DQ975550/ DQ975551/ DQ975552/ DQ975553/ DQ975554/ DQ975555/ DQ975556/ DQ975557/ DQ975558/ DQ975559/ DQ975560/ DQ975561/ DQ975562/ DQ975563/ DQ975564/ DQ975565/ DQ975566/ DQ975567/ DQ975568/ DQ975569/ 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DQ975970/ DQ975971/ DQ975972/ DQ975973/ DQ975974/ DQ975975/ DQ975976/ DQ975977/ DQ975978/ DQ975979/ DQ975980/ DQ975981/ DQ975982/ DQ975983/ DQ975984/ DQ975985/ DQ975986/ DQ975987/ DQ975988/ DQ975989/ DQ975990/ DQ975991/ DQ975992/ DQ975993/ DQ975994/ DQ975995/ DQ975996/ DQ975997/ DQ975998/ DQ975999/ DQ976000/ DQ976001/ DQ976002/ DQ976003/ DQ976004/ DQ976005/ DQ976006/ DQ976007/ DQ976008/ DQ976009/ DQ976010/ DQ976011/ DQ976012/ DQ976013/ DQ976014/ DQ976015/ DQ976016/ DQ976017/ DQ976018/ DQ976019/ DQ976020/ DQ976021/ DQ976022/ DQ976023/ DQ976024/ DQ976025/ DQ976026/ DQ976027/ DQ976028/ DQ976029/ DQ976030/ DQ976031/ DQ976032/ DQ976033/ DQ976034/ DQ976035/ DQ976036/ DQ976037/ DQ976038/ DQ976039/ DQ976040/ DQ976041/ DQ976042/ DQ976043/ DQ976044/ DQ976045/ DQ976046/ DQ976047/ DQ976048/ DQ976049/ DQ976050/ DQ976051/ DQ976052/ DQ976053/ DQ976054/ DQ976055/ DQ976056/ DQ976057/ DQ976058/ DQ976059/ DQ976060/ DQ976061/ DQ976062/ DQ976063/ DQ976064/ DQ976065/ DQ976066/ DQ976067/ DQ976068/ DQ976069/ 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DQ976270/ DQ976271/ DQ976272/ DQ976273/ DQ976274/ DQ976275/ DQ976276/ DQ976277/ DQ976278/ DQ976279/ DQ976280/ DQ976281/ DQ976282/ DQ976283/ DQ976284/ DQ976285/ DQ976286/ DQ976287/ DQ976288/ DQ976289/ DQ976290/ DQ976291/ DQ976292/ DQ976293/ DQ976294/ DQ976295/ DQ976296/ DQ976297/ DQ976298/ DQ976299/ DQ976300/ DQ976301/ DQ976302/ DQ976303/ DQ976304/ DQ976305/ DQ976306/ DQ976307/ DQ976308/ DQ976309/ DQ976310/ DQ976311/ DQ976312/ DQ976313/ DQ976314/ DQ976315/ DQ976316/ DQ976317/ DQ976318/ DQ976319/ DQ976320/ DQ976321/ DQ976322/ DQ976323/ DQ976324/ DQ976325/ DQ976326/ DQ976327/ DQ976328/ DQ976329/ DQ976330/ DQ976331/ DQ976332/ DQ976333/ DQ976334/ DQ976335/ DQ976336/ DQ976337/ DQ976338/ DQ976339/ DQ976340/ DQ976341/ DQ976342/ DQ976343/ DQ976344/ DQ976345/ DQ976346/ DQ976347/ DQ976348/ DQ976349/ DQ976350/ DQ976351/ DQ976352/ DQ976353/ DQ976354/ DQ976355/ DQ976356/ DQ976357/ DQ976358/ DQ976359/ DQ976360/ DQ976361
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR16448; United States / NCRR NIH HHS / RR / P20 RR16454
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Ribosomal; 0 / RNA, Ribosomal, 16S
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78. Decavalas G, Adonakis G, Androutsopoulos G, Gkermpesi M, Kourounis G: Sarcoidosis of the vulva: a case report. Arch Gynecol Obstet; 2007 Mar;275(3):203-5
MedlinePlus Health Information. consumer health - Vulvar Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sarcoidosis of the vulva: a case report.
  • Sarcoidosis of the vulva is a very rare condition.
  • The histology revealed sarcoidosis of the vulva.
  • [MeSH-major] Sarcoidosis / pathology. Vulva / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Biopsy. Female. Humans. Middle Aged

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  • (PMID = 16912856.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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79. Mamoon N, Mushtaq S, Akhter N, Aslam A, Chaudary A, Rashid M: Immature teratoma of the vulva with an inguinal lymph node metastasis: report of a case and review of literature. Int J Gynecol Pathol; 2010 Mar;29(2):197-200
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immature teratoma of the vulva with an inguinal lymph node metastasis: report of a case and review of literature.
  • Neoplasms of the vulva are rare and most commonly reported amongst them are epithelial tumors.
  • We report the only case of an immature teratoma of the vulva with inguinal lymph node metastasis.
  • [MeSH-major] Lymph Nodes / pathology. Teratoma / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Histocytochemistry. Humans. Lymphatic Metastasis

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  • (PMID = 20173508.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Jiao LX, Hu LN, Xiong ZA, Feng LH, Zhang Y, Tian YB, Chen WZ, Wang ZB: [Treatment of nonneoplastic epithelial disorders of skin and mucosa of vulva with focused ultrasound]. Zhonghua Fu Chan Ke Za Zhi; 2007 Jan;42(1):6-8
MedlinePlus Health Information. consumer health - Vulvar Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of nonneoplastic epithelial disorders of skin and mucosa of vulva with focused ultrasound].
  • OBJECTIVE: To explore the clinical efficacy of focused ultrasound for patients with white lesions of the vulva, as well as its safety and feasibility.
  • METHODS: Clinical data of 941 patients with white lesions of the vulva treated with focused ultrasound from June 2003 to December 2005 were retrospectively reviewed.
  • Meanwhile, pathological diagnosis was performed in all the patients before treatment, in which 498 cases were squamous hyperplasia, 342 cases were lichen sclerosus and 101 cases were lichen sclerosus with squamous hyperplasia.
  • The symptoms of pruritus in the vulva and the changes in the color and elasticity of the vulvar lesions were observed.
  • Pruritus of vulva recurred in 101 patients (11.2%) one year after treatment; however, these patients still had a response to the second or third treatment.
  • CONCLUSIONS: Focused ultrasound therapy is a highly effective instrument in treatment of white lesions of the vulva.
  • It can not only relieve the symptoms of itching, but is also helpful in recovering the color and elasticity of the vulva.
  • [MeSH-major] Ultrasonic Therapy / methods. Vulvar Diseases / therapy. Vulvar Lichen Sclerosus / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Edema / etiology. Edema / therapy. Female. Humans. Hyperplasia. Middle Aged. Retrospective Studies. Skin Diseases / etiology. Skin Diseases / therapy. Treatment Outcome. Vulva / pathology

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  • (PMID = 17331412.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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81. Thangavelu A, Andrew A, Buxton EJ: Groin recurrence following Stage 1A squamous cell carcinoma of the vulva. Gynecol Oncol; 2006 Apr;101(1):172-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Groin recurrence following Stage 1A squamous cell carcinoma of the vulva.
  • BACKGROUND: It has been well established that stage 1 squamous cell carcinomas of the vulva with a depth of stromal invasion less than 1 mm have a <1% risk of lymph node involvement.
  • CASE: We present two cases of stage 1A microinvasive cancer of the vulva that presented with groin recurrence 3 months and 3 years following their primary surgery respectively.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Neoplasm Recurrence, Local / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Female. Groin. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Middle Aged. Neoplasm Staging

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  • [CommentIn] Gynecol Oncol. 2006 Oct;103(1):375-6; author reply 376-7 [16890982.001]
  • (PMID = 16274738.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Pisani C, Poggiali S, De Padova L, Andreassi A, Bilenchi R: Basal cell carcinoma of the vulva. J Eur Acad Dermatol Venereol; 2006 Apr;20(4):446-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma of the vulva.
  • We describe a woman with BCC of the vulva treated with local resection.
  • Although the aetiology of vulvar BCC is not known, early diagnosis is important.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 16643146.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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83. Narayansingh GV, Miller ID, Sharma M, Welch CJ, Sharp L, Parkin DE, Cruickshank ME: The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva. Br J Cancer; 2005 Jan 31;92(2):222-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva.
  • Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma (SCC) of the vulva.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lymphatic Metastasis / pathology. Neoplasm Recurrence, Local / diagnosis. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Keratins / metabolism. Middle Aged. Prognosis. Retrospective Studies

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  • [Cites] Lancet. 2001 Jan 6;357(9249):15-20 [11197354.001]
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  • (PMID = 15655537.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2361832
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84. Baruah J, Roy KK, Rahman SM, Kumar S, Pushparaj M, Mirdha AR: Angiokeratoma of vulva with coexisting human papilloma virus infection: a case report. Arch Gynecol Obstet; 2008 Aug;278(2):165-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiokeratoma of vulva with coexisting human papilloma virus infection: a case report.
  • We report a 25-year-old unmarried girl who developed multiple papular lesions on both labia majora with the past history of documented HPV-6 viral infection in the vulva.
  • To the best of our knowledge this is the first case of angiokeratoma of vulva following chronic HPV infection.
  • [MeSH-major] Angiokeratoma / virology. Human papillomavirus 6 / isolation & purification. Papillomavirus Infections / complications. Skin Neoplasms / virology. Vulva
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18193251.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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85. Zhou J, Ha BK, Schubeck D, Chung-Park M: Myxoid epithelioid leiomyoma of the vulva: a case report. Gynecol Oncol; 2006 Oct;103(1):342-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid epithelioid leiomyoma of the vulva: a case report.
  • BACKGROUND: Smooth muscle tumors of the vulva are rare and sometimes create diagnostic difficulty because of unusual morphological features.
  • CASE: A 29-year-old African-American female presented with a vulval mass during her 5th week of pregnancy.
  • CONCLUSION: Up to now, there are only a few cases of myxoid epithelioid leiomyoma of the vulva reported in English literature.
  • We review previously reported cases and discuss the morphologic differential diagnosis.
  • The mass presented in this report was the largest benign epithelioid leiomyoma in the literature.
  • [MeSH-major] Leiomyoma, Epithelioid / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 16765425.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Félix MA: An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva. Bioessays; 2005 Aug;27(8):765-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva.
  • For example, Wnt signaling is recruited, sometimes redundantly with other molecular pathways, in four cell specification events during Caenorhabditis elegans vulva development, including the activation of vulval differentiation.
  • Strikingly,a recent study finds that Wnts act to repress vulval differentiation in the nematode Pristionchus pacificus,1 demonstrating evolutionary flexibility in the use of intercellular signaling pathways.
  • [MeSH-major] Intercellular Signaling Peptides and Proteins / metabolism. Vulva / embryology
  • [MeSH-minor] Animals. Caenorhabditis elegans. Caenorhabditis elegans Proteins / physiology. Cell Lineage. Evolution, Molecular. Female. Models, Biological. Mutation. Nematoda. Signal Transduction. Wnt Proteins

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 16015606.001).
  • [ISSN] 0265-9247
  • [Journal-full-title] BioEssays : news and reviews in molecular, cellular and developmental biology
  • [ISO-abbreviation] Bioessays
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Wnt Proteins
  • [Number-of-references] 40
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87. Ordon W, Malinowski A, Pawłowicz P: [Extensive vulva cancer with enormous tumor of the vagina]. Ginekol Pol; 2008 Jan;79(1):60-4
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  • [Title] [Extensive vulva cancer with enormous tumor of the vagina].
  • The following is a case report documenting a 53-year old patient with extremely advanced vulva cancer (stage IV).
  • The patient needed urgent operative treatment because of massive bleeding from large tumor located inside and out of the vagina.
  • The prime step was to stop tumor hemorrhage, perform cystotomy and decompression of the urinary bladder and exteriorization of artificial anus.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / surgery. Vaginal Neoplasms / pathology. Vaginal Neoplasms / surgery. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery
  • [MeSH-minor] Fatal Outcome. Female. Humans. Lymphatic Metastasis. Middle Aged. Reoperation

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  • (PMID = 18510053.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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88. Nola M, Blazanovic A, Dotlic S, Morovic A, Tomicic I, Jukic S: Invasive squamous cell carcinoma of vulva: prognostic significance of clinicopathologic parameters. Croat Med J; 2005 Jun;46(3):436-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive squamous cell carcinoma of vulva: prognostic significance of clinicopathologic parameters.
  • AIM: To investigate the prognostic significance of several clinicopathologic parameters in patients with invasive squamous cell carcinoma of the vulva.
  • METHODS: We retrospectively studied 43 patients with invasive squamous cell carcinoma of the vulva treated with radical vulvectomy at the Department of Gynecology and Obstetrics at Zagreb University School of Medicine, Croatia, in the period from 1978-1996.
  • Cox proportional hazard analysis was performed to examine the prognostic significance of age, menstrual status, clinical stage, diameter and localization of the tumor, histological grade, nuclear grade, depth of tumor invasion, presence of vascular space invasion, tumor growth pattern, presence of lymph node metastasis, DNA ploidy, proliferative activity, and mode of therapy.
  • The results of univariate statistical analysis confirmed that statistically significant prognostic parameters included the age of patients (P=0.038), clinical stage (P=0.001), nuclear grade (P=0.002), the depth of tumor invasion (P<0.001), and presence of lymph node metastasis (P=0.001).
  • On the other hand, the results of multivariate statistical analysis showed that only the depth of tumor invasion (P<0.001) can be considered independent, statistically significant prognostic parameter.
  • CONCLUSION: Our data suggest that the depth of tumor invasion represents the most important prognostic parameter in the group of patients with invasive squamous vulvar carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Vulvar Neoplasms / mortality. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Croatia / epidemiology. Female. Humans. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 15861524.001).
  • [ISSN] 0353-9504
  • [Journal-full-title] Croatian medical journal
  • [ISO-abbreviation] Croat. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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89. Félix MA: Cryptic quantitative evolution of the vulva intercellular signaling network in Caenorhabditis. Curr Biol; 2007 Jan 23;17(2):103-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cryptic quantitative evolution of the vulva intercellular signaling network in Caenorhabditis.
  • BACKGROUND: The Caenorhabditis vulva is formed from a row of Pn.p precursor cells, which adopt a spatial cell-fate pattern-3 degrees 3 degrees 2 degrees 1 degrees 2 degrees 3 degrees -centered on the gonadal anchor cell.
  • Direct induction of the 1 degrees fate as in C. elegans appeared within the genus. C. briggsae displays a graded induction of 1 degrees and 2 degrees fates, with 1 degrees fate induction requiring a longer time than in C. elegans, and a reduced lateral inhibition of adjacent 1 degrees fates. C. remanei displays a strong lateral induction of 2 degrees fates relative to vulval-fate activation in the central cell.
  • CONCLUSIONS: Quantitative evolution in the roles of graded induction by LIN-3/EGF and Notch signaling is demonstrated for the Caenorhabditis vulva signaling network.
  • [MeSH-minor] Animals. Caenorhabditis elegans Proteins / physiology. Epidermal Growth Factor / physiology. Female. Gene Expression. Receptors, Notch / physiology. Vulva / embryology. ras Proteins / physiology

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  • [CommentIn] Curr Biol. 2007 Mar 6;17(5):R172-4 [17339017.001]
  • (PMID = 17240335.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / Receptors, Notch; 148412-70-8 / Lin-3 protein, C elegans; 62229-50-9 / Epidermal Growth Factor; EC 3.6.5.2 / ras Proteins
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90. Alo PL, Galati GM, Sebastiani V, Ricci F, Visca P, Mariani L, Romagnoli F, Lombardi G, Tondo UD: Fatty acid synthase expression in Paget's disease of the vulva. Int J Gynecol Pathol; 2005 Oct;24(4):404-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatty acid synthase expression in Paget's disease of the vulva.
  • We explored the immunohistochemical expression of fatty acid synthase (FAS) in Paget's disease of the vulva (PDV) and its association with clinico-pathological features.
  • [MeSH-major] Fatty Acid Synthases / analysis. Paget Disease, Extramammary / enzymology. Vulvar Neoplasms / enzymology
  • [MeSH-minor] Aged. Aged, 80 and over. Cytoplasm / enzymology. Female. Humans. Immunohistochemistry. Neoplasm Invasiveness

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  • (PMID = 16175090.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.3.1.85 / Fatty Acid Synthases
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91. Dalpé G, Brown L, Culotti JG: Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline. Development; 2005 Mar;132(6):1387-400
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  • [Title] Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline.
  • Vulva development in C. elegans involves cell fate specification followed by a morphogenesis phase in which homologous mirror image pairs within a linear array of primordial vulva cells form a crescent shape as they move sequentially towards a midline position within the array.
  • Here, we show that the semaphorin 1a SMP-1, and its plexin receptor PLX-1, are required for the movement of homologous pairs of vulva cells towards this midline position.
  • SMP-1 is upregulated on the lumen membrane of each primordial vulva cell as it enters the forming vulva and apparently attracts the next flanking homologous PLX-1-expressing vulva cells towards the lumen surface of the ring.
  • This smp-1- and plx-1-dependent process repeats until seven rings are stacked along the dorsoventral axis, creating a common vulva lumen.
  • Ectopic expression of SMP-1 suggests it has an instructive role in vulva cell migration.
  • At least two parallel acting pathways are required for vulva formation: one requires SMP-1, PLX-1 and CED-10; and another requires the MIG-2 Rac GTPase and its putative activator UNC-73.
  • [MeSH-major] Caenorhabditis elegans Proteins / metabolism. Nerve Tissue Proteins / metabolism. Receptors, Cell Surface / metabolism. Semaphorins / metabolism. Vulva / embryology
  • [MeSH-minor] Animals. Caenorhabditis elegans / embryology. Caenorhabditis elegans / metabolism. Female. Mutation. ras Proteins / metabolism

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  • (PMID = 15716342.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS41397
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / Nerve Tissue Proteins; 0 / Receptors, Cell Surface; 0 / Semaphorins; 0 / UNC-73 protein, C elegans; 0 / plx-1 protein, C elegans; EC 3.6.5.2 / ras Proteins
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92. Bakalianou K, Salakos N, Iavazzo C, Paltoglou G, Papadias K, Gregoriou O, Kondi-Pafiti A: Paget's disease of the vulva. A ten-year experience. Eur J Gynaecol Oncol; 2008;29(4):368-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paget's disease of the vulva. A ten-year experience.
  • BACKGROUND: Paget's disease of the vulva is a rare neoplasmatic lesion which mainly affects postmenopausal women.
  • [MeSH-major] Paget Disease, Extramammary / pathology. Vulva / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Prognosis. Retrospective Studies

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  • (PMID = 18714571.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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93. Dash S, Awasthi RT, Bandana K: Pedunculated angiomyxoma of the vulva - a rare clinical entity. Kathmandu Univ Med J (KUMJ); 2005 Oct-Dec;3(4):423-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pedunculated angiomyxoma of the vulva - a rare clinical entity.
  • BACKGROUND: Aggressive angiomyxoma is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females.
  • CASE: A 33-year-old parous woman with a slow growing pedunculated soft tissue tumour of the vulva which later underwent surface ulceration.
  • Pathological findings in the case were suggestive of an aggressive angiomyxoma, a distinctive soft tissue non-malignant tumour, which could, at times be locally aggressive.
  • [MeSH-major] Myxoma / pathology. Skin Neoplasms / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 16449849.001).
  • [ISSN] 1812-2027
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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94. Grabiec M, Walentowicz M, Marszałek A: Multiple skin metastases to vulva from carcinoma of the cervical stump. Ginekol Pol; 2010 Feb;81(2):140-3
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  • [Title] Multiple skin metastases to vulva from carcinoma of the cervical stump.
  • CASE: We present a case of skin metastases in patients with squamous cell carcinoma of the cervical stump after the previous supracervical hysterectomy for benign disease of the uterus.
  • The extensive skin changes on vulva and perineum occurred after radical trachelectomy and external radiation therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / secondary. Hysterectomy / adverse effects. Skin Neoplasms / secondary. Uterine Cervical Neoplasms / etiology. Vulvar Neoplasms / secondary
  • [MeSH-minor] Disease Progression. Fatal Outcome. Female. Humans. Middle Aged


95. Doufekas K, Duncan TJ, Williamson KM, Varma S, Nunns D: Mohs micrographic surgery for dermatofibrosarcoma protuberans of the vulva. Obstet Gynecol Int; 2009;2009:547672

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs micrographic surgery for dermatofibrosarcoma protuberans of the vulva.
  • Introduction. Dermatofibrosarcoma Protuberans (DFSP) is a rare cutaneous tumour of low/intermediate malignant potential, which occasionally arises on the vulva.
  • However, no report to date has described its use in vulval DFSP. Case History.
  • Representative vertical sections used in WLE assess less than 1% of the total tumour margin.
  • 100% of the tumour margin is microscopically examined.

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  • (PMID = 20041131.001).
  • [ISSN] 1687-9597
  • [Journal-full-title] Obstetrics and gynecology international
  • [ISO-abbreviation] Obstet Gynecol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2796212
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96. Mandal S, Dhingra K, Roy S, Khurana N: Aggressive angiomyxoma of the vulva presenting as a pedunculated swelling. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):259-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive angiomyxoma of the vulva presenting as a pedunculated swelling.
  • Aggressive angiomyxoma is a rare, locally aggressive soft tissue tumor that has high propensity for local recurrence.
  • It involves mainly the pelvis, vulva, perineum, vagina and urinary bladder in adult women in the reproductive age.
  • [MeSH-major] Myxoma / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness / pathology. Pregnancy

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  • (PMID = 18603701.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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97. Tanaka H, Umekawa T, Nagao K, Ishihara A, Toyoda N: Adenocarcinoma of mammary-like glands in the vulva successfully treated by weekly paclitaxel. Int J Gynecol Cancer; 2005 May-Jun;15(3):568-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of mammary-like glands in the vulva successfully treated by weekly paclitaxel.
  • The tumor appeared as cell clusters with linear arrangements.
  • This disease was diagnosed as an adenocarcinoma arising in mammary-like glands of the vulva.
  • In our case, the fine-needle aspiration cytology was a rapid and minimally invasive method of diagnosis, and the findings were extremely similar to those of the scirrhus type of primary breast carcinoma.
  • Rapid and accurate diagnosis made with this technique might contribute to a good prognosis in the early-staged cases.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents, Phytogenic / therapeutic use. Paclitaxel / therapeutic use. Vulvar Neoplasms / drug therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Humans. Mammary Glands, Human

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  • (PMID = 15882189.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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98. Cormio G, Loizzi V, Carriero C, Cazzolla A, Putignano G, Selvaggi L: Groin recurrence in carcinoma of the vulva: management and outcome. Eur J Cancer Care (Engl); 2010 May;19(3):302-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Groin recurrence in carcinoma of the vulva: management and outcome.
  • The aim of the study was to investigate the management and outcome of inguinal recurrence in vulvar carcinoma patients.
  • A retrospective chart review was conducted on 140 patients with squamous cell carcinoma of the vulva treated between 1994 and 2006.
  • Median interval between primary treatment of vulvar cancer and groin recurrence was 7 months.
  • One patient died following surgery; 19 patients died of disease with the median survival after diagnosis of inguinal recurrence of 9 months.
  • In univariate analysis, stage and grade at diagnosis, age and performance status at the recurrent disease, and the extent of residual tumour after resection of groin recurrence were predictors for survival.
  • Groin recurrences from vulvar carcinoma carry a poor prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Neoplasm Recurrence, Local / therapy. Vulvar Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy / methods. Female. Groin. Humans. Lymph Node Excision. Lymphatic Metastasis. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 19832900.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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99. Hanprasertpong J, Chichareon S, Wootipoom V, Buhachat R, Tocharoenvanich S, Geater A: Clinico-pathological profile of vulva cancer in southern Thailand: analysis of 66 cases. J Med Assoc Thai; 2005 May;88(5):575-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinico-pathological profile of vulva cancer in southern Thailand: analysis of 66 cases.
  • OBJECTIVE: To evaluate the clinico-pathologic findings and treatment outcome of women with vulva cancer in Southern Thailand.
  • Two most common presentations were vulva mass (89.4%) and pruritus (57.6%).
  • [MeSH-major] Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Retrospective Studies. Thailand. Treatment Outcome

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  • (PMID = 16149671.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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100. Li CZ, Bian DH, Wang L, Wang HQ, Cao YD, Yin NG, Zhao CL: [Short and long-term efficacy of focused ultrasound therapy for vulva dystrophy]. Zhonghua Fu Chan Ke Za Zhi; 2007 Jan;42(1):9-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Short and long-term efficacy of focused ultrasound therapy for vulva dystrophy].
  • OBJECTIVE: To investigate the short and long-term efficacy and complications, as well as the influential factors of focused ultrasound for the treatment of vulva dystrophy.
  • METHODS: Seventy-six eligible patients with vulva dystrophy were randomized and treated with focused ultrasound between 1999 and 2002.
  • Moreover, two patients (1 SH and 1 LS) had superficial ulcers on the treated vulva skin two weeks after ultrasound treatment, which were cured without any complications with local anti-inflammatory drugs for 2-3 weeks.
  • CONCLUSIONS: Vulva dystrophy can be treated with focused ultrasound effectively and safely.
  • [MeSH-major] Ultrasonic Therapy / methods. Vulva / pathology. Vulvar Diseases / therapy. Vulvar Lichen Sclerosus / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Blister / etiology. Blister / therapy. Colposcopy. Female. Follow-Up Studies. Humans. Hyperplasia. Middle Aged. Treatment Outcome

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  • (PMID = 17331413.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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