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1. Krohn J, Monge OR: [Conjunctival primary acquired melanosis]. Tidsskr Nor Laegeforen; 2005 Sep 22;125(18):2480-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Conjunctival primary acquired melanosis].
  • [Transliterated title] Primaer akkvirert melanose i conjunctiva.
  • BACKGROUND: Pigmented lesions of the conjunctiva may represent primary acquired melanosis.
  • If histological examination reveals atypical melanocytes in the epithelial layer of the conjunctiva, there is a close to 50% risk of transformation to a conjunctival malignant melanoma.
  • A combination of surgical excision and cryotherapy is the most widely recommended treatment for conjunctival primary acquired melanosis with atypia.
  • RESULTS AND INTERPRETATION: Pigmented conjunctival lesions arising in adults may represent primary acquired melanosis with atypia.
  • [MeSH-major] Conjunctival Diseases. Melanosis
  • [MeSH-minor] Aged. Antibiotics, Antineoplastic / administration & dosage. Conjunctival Neoplasms / etiology. Conjunctival Neoplasms / pathology. Cryotherapy. Diagnosis, Differential. Humans. Male. Melanoma / etiology. Melanoma / pathology. Middle Aged. Mitomycin / administration & dosage. Ophthalmic Solutions / administration & dosage

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  • (PMID = 16186865.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Ophthalmic Solutions; 50SG953SK6 / Mitomycin
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2. Offret H, Porras J, Fabre M, Offret O, Labetoulle M: [Adenomatous hyperplasia of the conjunctiva]. J Fr Ophtalmol; 2008 Dec;31(10):1037-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatous hyperplasia of the conjunctiva].
  • [Transliterated title] Hyperplasie adénomateuse de la conjonctive.
  • We report a case of adenomatous hyperplasia of the conjunctiva.
  • A 42-year-old man was referred for a left conjunctival lesion involving the caruncle; the histopathological patterns revealed benign adenomatous hyperplasia, a disease that may originate in the conjunctiva.
  • Adenomatous hyperplasia of the conjunctiva is a benign condition.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Diseases / pathology

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  • (PMID = 19107081.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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3. Offret H, Quillard J, Offret O, Labetoulle M: [Transitional carcinoma of the conjunctiva]. J Fr Ophtalmol; 2007 Sep;30(7):768-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Transitional carcinoma of the conjunctiva].
  • [Transliterated title] Carcinome transitionnel de la conjonctive.
  • We report a case of transitional carcinoma originating from the conjunctiva.
  • An 86-year-old woman was referred for a right conjunctival swelling lasting 6 months after a first surgical excision.
  • Transitional carcinoma may originate in the conjunctiva.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Conjunctival Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17878831.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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4. Oduntan AO: Cellular inflammatory response induced by sensory denervation of the conjunctiva in monkeys. J Anat; 2005 Mar;206(3):287-94

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cellular inflammatory response induced by sensory denervation of the conjunctiva in monkeys.
  • Clinical evidence has shown that the conjunctiva also responds to sensory denervation, but little is known of the cytology of the conjunctival tissue response to denervation.
  • The purpose of this study therefore was to investigate the cytological aspects of tissue response induced in the conjunctiva of monkeys by sensory denervation.
  • These various operations were performed for other experimental purposes, but the conjunctival tissues from the animals were suitable and available to study the cytology of the inflammatory response induced in the tissue following the sensory denervation.
  • Complete or severe ophthalmic nerve transection induced significant inflammatory responses, which were largely confined to the tarsal region of the conjunctiva.
  • The number of macrophages in the conjunctiva also increased.
  • The restriction of the conjunctival tissue response to the tarsal region was considered to be due to the friction between the tarsal conjunctiva (and the hard tarsal plate) and the cornea during blinking.
  • This study shows that sensory denervation of the conjunctiva elicits an inflammatory response characterized by substantial infiltration of the epithelium by neutrophil and macrophage and disorganization of the conjunctival tissue.
  • [MeSH-major] Conjunctiva / immunology. Conjunctiva / innervation. Keratitis / immunology. Neurons, Afferent

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  • (PMID = 15733301.001).
  • [ISSN] 0021-8782
  • [Journal-full-title] Journal of anatomy
  • [ISO-abbreviation] J. Anat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 35
  • [Other-IDs] NLM/ PMC1571469
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5. Panneton WM, Hsu H, Gan Q: Distinct central representations for sensory fibers innervating either the conjunctiva or cornea of the rat. Exp Eye Res; 2010 Mar;90(3):388-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinct central representations for sensory fibers innervating either the conjunctiva or cornea of the rat.
  • The eyeball however indents this laminar sheet and is shrouded by different layers: the cornea/sclera, the conjunctiva, and hairy skin.
  • The HRP cocktail was injected either into the stroma of the cornea, the mucosa of the conjunctiva, or the supraorbital and infraorbital nerves.
  • Injections of the conjunctiva densely labeled laminae I-III in the C1 dorsal horn, while laminae IV-V were diffusely labeled.
  • In other cases the cornea was injected either after cutting the supraorbital and infraorbital nerves or the conjunctiva was injected after enucleating the eyeball.
  • Injecting the conjunctiva after enucleating the eyeball densely labeled the C1 projection to the dorsal horn, a small patch in lamina I in the MDH, as well as the rostral trigeminal complex.
  • We also propose the palpebral conjunctiva mucosa is represented in the C1 dorsal horn, and speculate that the bulbar conjunctiva overlaps with that of the cornea in lamina I.
  • The relationship of the cornea and conjunctiva is intimate, and investigators must be very careful when attempting to stimulate them in isolation.

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  • (PMID = 20004193.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL064772-02; United States / NHLBI NIH HHS / HL / R01 HL064772; United States / NHLBI NIH HHS / HL / R01 HL64772; United States / NHLBI NIH HHS / HL / HL064772-04; United States / NHLBI NIH HHS / HL / R01 HL064772-03; United States / NHLBI NIH HHS / HL / R01 HL064772-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • [Other-IDs] NLM/ NIHMS167556; NLM/ PMC2824013
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6. Coman OA, Tăranu B, Ghiţă Cristescu I, Fulga I: Particularities of vascular reactivity of the conjunctiva and iris in rats. Rom J Morphol Embryol; 2008;49(1):53-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Particularities of vascular reactivity of the conjunctiva and iris in rats.
  • Considering that the conjunctiva and iris are developed from different embryological origins, an analysis of any possible differences in the density and type of adrenoceptors between these two areas was tried.
  • Six groups (six rats per group) were used by recording the iris and conjunctival vessels after eye instillations with solutions of adrenaline 0.1%, isoprenaline chlorhydrate 0.00002% and distilled water.
  • The analysis of the two groups treated with adrenaline 0.1% showed a different reactivity of the vessels from the conjunctiva and iris, respectively.
  • On the contrary, the conjunctival vessels showed initially mild, but significant vasodilatation, while vasoconstriction started later and was not as intense as for the iris vessels.
  • On the contrary, the conjunctival vessels showed a significant vasodilatation.
  • The differences in the vascular reactivity of the two ocular areas (conjunctiva and iris) to vasoactive amines (epinephrine, isoprenaline) support the idea that beta 2 adrenergic receptors are present only in conjunctiva vessels but not in iris vessels, while alpha adrenoceptors are present in both vascular territories.
  • [MeSH-major] Conjunctiva / blood supply. Iris / blood supply. Vascular Resistance / physiology

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  • (PMID = 18273503.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Ophthalmic Solutions; L628TT009W / Isoproterenol; YKH834O4BH / Epinephrine
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7. Ha SW, Lee JM, Jeung WJ, Ahn HB: Clinical effects of conjunctiva-Müller muscle resection in anophthalmic ptosis. Korean J Ophthalmol; 2007 Jun;21(2):65-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical effects of conjunctiva-Müller muscle resection in anophthalmic ptosis.
  • PURPOSE: To evaluate the clinical effects of conjunctiva-Muller muscle resection through conjunctival incision in anophthalmic patients with mild ptosis.
  • METHODS: Conjunctiva-Müller muscle resection was performed by one surgeon in 8 patients (8 eyes) who had received evisceration or enucleation and responded to 10% phenylephrine solution to correct ptosis.
  • The Müller muscle was resected 7.5 to 9 mm through conjunctival incision during surgery to match the MRD 1 of sound eye.
  • CONCLUSIONS: Conjunctiva-Müller muscle resection is one of the effective methods of correcting mild ptosis in anophthalmic patients.
  • [MeSH-major] Anophthalmos / complications. Blepharoptosis / surgery. Conjunctiva / surgery. Facial Muscles / surgery. Ophthalmologic Surgical Procedures / methods

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  • (PMID = 17592234.001).
  • [ISSN] 1011-8942
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2629698
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8. Camesasca FI, Bianchi C, Beltrame G, Caporossi A, Piovella M, Rapisarda A, Tassinari G, Zeppa L, Dexamethasone-Tobramycin Combination Study Group FT: Control of inflammation and prophylaxis of endophthalmitis after cataract surgery: A multicenter study. Eur J Ophthalmol; 2007 Sep-Oct;17(1):733-742

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pertaining to the two therapeutic regimens, efficacy, side effects, and clinical findings such as uncorrected visual acuity, intraocular pressure, edema or hyperemia of eyelids and/or conjunctiva, conjunctival and/or ciliary vessels congestion, decreased corneal transparency, corneal edema, Descemet folds, anterior chamber Tyndall and depth, and posterior synechiae were also comparable.

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  • (PMID = 28221513.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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9. Cengiz Y, Altintas O, Manav Ay G, Caglar Y: Comparison of the effectiveness of mitomycin-C and Viscoat on delayed adjustable strabismus surgery in rabbits. Eur J Ophthalmol; 2005 Sep - Oct 2005;15(5):530-535
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: When length and strength of the adjustment, adhesions between muscle and sclera, and adhesions between muscle and conjunctiva were taken into consideration, there was no statistically significant difference among M, V, and C groups at postoperative weeks 1 and 3.

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  • (PMID = 28221456.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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10. Bonci PO, Bonci PA, Lia A: Suspension made with amniotic membrane: Clinical trial. Eur J Ophthalmol; 2005 Jul-Aug;15(4):441-445

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: In all patients, after 15 to 30 days the corneas became negative to fluorescein staining test and the epithelium seemed more complete and regular, there was an evident decrease of phlogistic situation in the conjunctiva, and an improvement of symptoms was referred by patients.

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  • (PMID = 28221412.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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11. Adiguzel U, Karabacak T, Sari A, Oz O, Cinel L: Cyclooxygenase-2 expression in primary and recurrent pterygium. Eur J Ophthalmol; 2007 Nov-Dec;17:879-884

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Pterygium is a proliferative, inflammatory, and invasive ocular surface disease associated with excessive ultraviolet radiation exposure and has several tumor-like characteristics.
  • METHODS: Immunohistochemical staining using a primary antibody for COX-2 was performed on 30 specimens with primary pterygium (20 pterygium without recurrence and 10 pterygium which recurred during a 12-month follow-up), 11 specimens with recurrent pterygium, and 8 specimens of conjunctival tumor.
  • As a control we used 10 specimens of normal conjunctiva.
  • RESULTS: Higher expression of COX-2 was detected in conjunctival tumor (87.5%) specimens and recurrent pterygium specimens (72.7%) compared to the both normal conjunctiva (30%) and primary pterygium without recurrence (30%).

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  • (PMID = 28221578.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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12. Rivas L, Lopez-Garcia JS, Murube J, Garcia-Lozano I: Different conjunctival adaptive response in patients with aqueous-deficient and with mucous-deficient dry eyes. Eur J Ophthalmol; 2007 Mar-Apr;17(2):160

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Different conjunctival adaptive response in patients with aqueous-deficient and with mucous-deficient dry eyes.
  • PURPOSE: To describe the different cellular adaptive patterns found in the conjunctival epithelium from patients with aqueous-deficient and mucous-deficient dry eyes.
  • METHODS: The authors studied different conjunctival areas, by impression cytology and by biopsy, 50 eyes with facial nerve paralysis (FNP), 50 eyes with ocular cicatricial pemphigoid (OCP), and 50 eyes from patients with primarily Sjgren syndrome (1SS).
  • Eyes with OCP, during clinical grades 1 and 2, showed a slow deterioration of the nonsecretory cells; but from clinical grade 3, there was a significant increase of the cellular size and the thickness of the conjunctiva.
  • From clinical grade 3 appeared a significant increase of nonsecretory cellular size and thickness of conjunctiva, with a significant decrease in goblet cell counts, and a PAS-negative staining.

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  • (PMID = 28221601.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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13. Mansour AM, Uwaydat SH, Chan CC: Long-term follow-up in Bietti crystalline dystrophy. Eur J Ophthalmol; 2007 Jul-Aug;17:680-682

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Two brothers are presented including the clinical findings, fluorescein angiography, electrophysiology (electroretinography [ERG], electrooculography [EOG], adaptometry), optical coherence tomography (OCT), and transmission electron microscopy of bulbar conjunctiva and peripheral blood lymphocytes.
  • RESULTS: The most striking features were deposits in the retina that were formed de novo with old ones replaced by choroidal atrophy in advanced stage of the disease.
  • Cytoplasmic lipid crystalline inclusions were found in lymphocytes and conjunctival fibroblasts by transmission electron microscopy.

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  • (PMID = 28221571.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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14. Keijser S, Missotten GS, De Wolff-Rouendaal D, Verbeke SL, Van Luijk CM, Veselic-Charvat M, De Keizer RJ: Impression cytology of melanocytic conjunctival tumours using the Biopore membrane. Eur J Ophthalmol; 2007 Jul-Aug;17:501-506

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impression cytology of melanocytic conjunctival tumours using the Biopore membrane.
  • PURPOSE: To compare a new Biopore membrane impression cytology method with the routinely used exfoliative cytology in patients with a melanocytic lesion of the conjunctiva.
  • METHODS: Sixty-eight consecutive patients with a conjunctival melanocytic lesion underwent Biopore membrane impression cytology as well as exfoliative cytology.
  • CONCLUSIONS: Biopore cytology can be used for cytologic sampling of conjunctival melanocytic lesions.

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  • (PMID = 28221541.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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15. Ta CN, Sinnar S, He L, Myung D, Mino De Kaspar H: Prospective randomized comparison of 1-day versus 3-day application of topical levofloxacin in eliminating conjunctival flora. Eur J Ophthalmol; 2007 Sep-Oct;17(1):689-695

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prospective randomized comparison of 1-day versus 3-day application of topical levofloxacin in eliminating conjunctival flora.
  • Conjunctival cultures were obtained prior to (T0) and after the application of antibiotics (T1).
  • Conjunctival cultures were obtained at timepoints T2 and T3.
  • RESULTS: A 1-day application of topical levofloxacin significantly reduced (p = 0.0004) the number of eyes with positive conjunctival cultures from 41 eyes (82%) to 23 eyes (46%).
  • CONCLUSIONS: The application of topical 0.5% levofloxacin for 1 or 3 days significantly reduced the number of eyes with positive conjunctival cultures.
  • The addition of 5% povidone-iodine further eliminated bacteria from the conjunctiva.

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  • (PMID = 28221506.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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16. Merle H, Donnio A, Richer R, Dubreuil F, Arfi S: Isolated conjunctival ulcerations as the first sign of Behets disease. Eur J Ophthalmol; 2006 Sep-Oct 2006;16(5):751-752

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated conjunctival ulcerations as the first sign of Behets disease.
  • PURPOSE: To report an unusual incident of isolated conjunctival ulcerations which preceded all other signs of Behets disease.
  • METHODS: Description of a 34-year-old woman of West Indian origin with an unremarkable medical history presenting with bilateral bulbar conjunctival ulcerations.
  • RESULTS: The authors noted the presence of a diffuse bilateral conjunctival hyperemia which was more pronounced at the temporal bulbar conjunctiva of the right eye and the nasal conjunctiva of the left eye, each having one ulceration.
  • One month later, the appearance of buccogenital aphthosis led to the diagnosis of Behets disease.
  • CONCLUSIONS: This observation is unusual, as the conjunctival ulcerations are isolated and precede the onset of all other symptoms of Behets disease.
  • Conjunctival ulcerations are rarely seen with Behets disease, but are characteristic enough to be included among the diagnostic criteria.

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  • (PMID = 28221629.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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17. Keklikci U, Soker SI, Soker Cakmak S, Ozkul S, Sakalar YB, Unlu K: Unilateral vernal keratoconjunctivitis: A case report. Eur J Ophthalmol; 2007 Nov-Dec;17:973-975

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Impression cytology specimens were taken from both upper eyelid tarsal conjunctiva.
  • On impression cytology examination, there was a significant increase in inflammation, presence of a honeycomb pattern, plasma cells, and mucus strands in the upper tarsal conjunctiva of the specimens.
  • CONCLUSIONS: Giant papillary conjunctivitis must be considered in differential diagnosis of unilateral vernal conjunctivitis.
  • Impression cytology method may be combined with the clinical findings in vernal keratoconjunctivitis diagnosis.

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  • (PMID = 28221593.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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18. Caca I, Unlu K, Buyukbayram H, Ari S: Conjunctival deposits as the first sign of systemic sarcoidosis in a pediatric patient. Eur J Ophthalmol; 2006 Jan - Feb;16(1):160-162

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival deposits as the first sign of systemic sarcoidosis in a pediatric patient.
  • In this study, the authors present a sarcoidosis patient without systemic signs diagnosed by histopathologic analysis of conjunctival deposits.
  • METHODS: A 10-year-old girl had bilateral, focal, multilobular, multiple pale yellow deposits in bulbar conjunctiva for a year.
  • A conjunctival biopsy was performed.
  • Conjunctival deposits were the first manifestation of sarcoidosis in the patient and the diagnosis of sarcoidosis was confirmed with a conjunctival biopsy.
  • CONCLUSIONS: To the authors' knowledge, this is the second study that reports a sarcoidosis patient with non-systemic involvement diagnosed after histopathologic analysis of conjunctival deposits. (Eur J Ophthalmol 2006; 16: 168-70).

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  • (PMID = 28221479.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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19. Arora R, Monga S, Mehta DK, Raina UK, Gogi A, Gupta SD: Malignant fibrous histiocytoma of the conjunctiva. Clin Exp Ophthalmol; 2006 Apr;34(3):275-8
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  • [Title] Malignant fibrous histiocytoma of the conjunctiva.
  • Eleven of these were classified as benign, and the rest were malignant fibrous histiocytomas.
  • Benign fibrous histiocytomas have been reported in the orbit, eyelid, episclera and conjunctiva.
  • Malignant fibrous histiocytoma has been well described in the orbit, but rarely as a primary conjunctival tumour.
  • The rarity of the tumour makes its diagnosis and management a challenge.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 16671910.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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20. Zembowicz A, Mandal RV, Choopong P: Melanocytic lesions of the conjunctiva. Arch Pathol Lab Med; 2010 Dec;134(12):1785-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanocytic lesions of the conjunctiva.
  • CONTEXT: Melanocytic proliferations are among the most common neoplasms of the conjunctiva.
  • OBJECTIVE: To comprehensively review clinical aspects, pathologic features, and management of melanocytic proliferations of the conjunctiva.
  • CONCLUSIONS: Classification, state of the art, and practical aspects of pathology of melanocytic proliferations of the conjunctiva are discussed.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanocytes / pathology. Melanoma / pathology. Melanosis / pathology. Nevus / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Proliferation. Humans

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  • (PMID = 21128776.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. Meyer P, Messerli J: [Inflammation of the conjunctiva]. Ther Umsch; 2009 Mar;66(3):153-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammation of the conjunctiva].
  • Inflammations of the conjunctiva represent some of the most frequent eye diseases in general and ophthalmologic practice.
  • [MeSH-minor] Adrenal Cortex Hormones / administration & dosage. Adrenal Cortex Hormones / therapeutic use. Adult. Anti-Bacterial Agents / administration & dosage. Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Conjunctivitis, Allergic / diagnosis. Conjunctivitis, Allergic / drug therapy. Conjunctivitis, Allergic / etiology. Conjunctivitis, Bacterial / diagnosis. Conjunctivitis, Bacterial / drug therapy. Conjunctivitis, Viral / diagnosis. Conjunctivitis, Viral / prevention & control. Diagnosis, Differential. Ectropion / diagnosis. Fluorescent Antibody Technique. Histamine Antagonists / administration & dosage. Histamine Antagonists / therapeutic use. Humans. Immune System Diseases / complications. Keratoconjunctivitis / diagnosis. Keratoconjunctivitis Sicca / diagnosis. Keratoconjunctivitis Sicca / etiology. Keratoconjunctivitis Sicca / therapy. Medical History Taking. Ophthalmic Solutions. Pemphigoid, Bullous / diagnosis. Pemphigoid, Bullous / therapy. Rosacea / diagnosis. Rosacea / drug therapy. Seasons. Trachoma / diagnosis. Trachoma / drug therapy

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  • (PMID = 19266461.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Histamine Antagonists; 0 / Ophthalmic Solutions
  • [Number-of-references] 0
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22. Malik A, Bhala S, Arya SK, Narang S, Punia RP, Sood S: Isolated cavernous hemangioma of conjunctiva. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):385-6
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  • [Title] Isolated cavernous hemangioma of conjunctiva.
  • A 70-year-old Indian female presented with a lobulated, violet-colored mass in the left eye involving the medial bulbar conjunctiva and caruncle.
  • Excisional biopsy was performed, and histopathologic examination confirmed the diagnosis of cavernous hemangioma of conjunctiva involving the caruncle.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Hemangioma, Cavernous / pathology

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  • [CommentIn] Ophthal Plast Reconstr Surg. 2011 Nov-Dec;27(6):464-5; author reply 465 [22072200.001]
  • (PMID = 20639785.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Lascaratos G, Gupta M, Bridges L, MacRae M: Myofibroma of the conjunctiva invading the cornea in infancy. J Pediatr Ophthalmol Strabismus; 2010;47 Online:e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myofibroma of the conjunctiva invading the cornea in infancy.
  • The authors report a novel case of solitary infantile myofibroma originating from the conjunctiva and encroaching over the limbus.
  • To the authors' knowledge, this is the first reported case of myofibroma originating from the conjunctiva and this case highlights the importance of considering myofibromatosis in the differential diagnosis of unusual conjunctival lesions.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Cornea / pathology. Myofibroma / pathology
  • [MeSH-minor] Actins / analysis. Biomarkers, Tumor / analysis. Female. Humans. Infant. Neoplasm Invasiveness. Vimentin / analysis

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21214145.001).
  • [ISSN] 1938-2405
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Vimentin
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24. Chong YY, Yodaiken M: MALT conjunctiva lymphoma. Ann Ophthalmol (Skokie); 2008 Fall-Winter;40(3-4):175-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MALT conjunctiva lymphoma.
  • We present a case of conjunctiva lymphoma that was diagnosed incidentally in the clinic.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology

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  • (PMID = 19230358.001).
  • [ISSN] 1530-4086
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Zinzani PL, Alinari L, Stefoni V, Loffredo A, Pichierri P, Polito E: Rituximab in primary conjunctiva lymphoma. Leuk Res; 2005 Jan;29(1):107-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rituximab in primary conjunctiva lymphoma.
  • Our experience with a patient with a primary conjunctiva lymphoma who was treated with conventional dose of rituximab obtaining a complete response without acute and late local toxicity for the eye.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Conjunctival Neoplasms / drug therapy. Lymphoma, Non-Hodgkin / drug therapy

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  • (PMID = 15541482.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
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26. Kim HJ, Shields CL, Eagle RC Jr, Shields JA: Fibrous histiocytoma of the conjunctiva. Am J Ophthalmol; 2006 Dec;142(6):1036-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibrous histiocytoma of the conjunctiva.
  • PURPOSE: To review the clinical features and course of six patients with fibrous histiocytoma (FH) of the conjunctiva.
  • METHODS: Chart review of six consecutive patients with unilateral cases of conjunctival FH was conducted.
  • The tumor was present for a mean of three months (median, five months; range, one to 12 months) and was unilateral (one right eye, five left eyes).
  • In all cases, the tumor was a tan, dome-shaped limbal mass in the conjunctival stroma with visible intrinsic vessels.
  • The mean tumor basal dimension was 7 mm (median, 5 mm; range, 4 to 11 mm).
  • Surgical resection was performed in all cases, and histopathologic study demonstrated benign FH in four cases and malignant FH in two cases.
  • Those cases with benign FH showed no recurrence over nine months (median, eight months; range, three to 18 months).
  • CONCLUSION: FH is a rare conjunctival tumor that can show benign or malignant features.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17157587.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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27. Efron N, Al-Dossari M, Pritchard N: In vivo confocal microscopy of the bulbar conjunctiva. Clin Exp Ophthalmol; 2009 May;37(4):335-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo confocal microscopy of the bulbar conjunctiva.
  • BACKGROUND: The aim of this work is to develop a more complete qualitative and quantitative understanding of the in vivo histology of the human bulbar conjunctiva.
  • METHODS: Laser scanning confocal microscopy (LSCM) was used to observe and measure morphological characteristics of the bulbar conjunctiva of 11 healthy human volunteer subjects.
  • RESULTS: The superficial epithelial layer of the bulbar conjunctiva is seen as a mass of small cell nuclei.
  • The conjunctival stroma is comprised of a dense meshwork of white fibres, through which traverse blood vessels containing cellular elements.
  • Goblet cells are also observed in the deeper epithelial layers, as well as conjunctival microcysts and mature forms of Langerhans cells.
  • The bulbar conjunctiva has a mean thickness of 32.9 +/- 1.1 microm, and a superficial and basal epithelial cell density of 2212 +/- 782 and 2368 +/- 741 cells/mm(2), respectively.
  • CONCLUSIONS: LSCM is a powerful technique for studying the human bulbar conjunctiva in vivo and quantifying key aspects of cell morphology.
  • The observations presented here may serve as a useful marker against which changes in conjunctival morphology due to disease, surgery, drug therapy or contact lens wear can be assessed.
  • [MeSH-major] Conjunctiva / cytology. Goblet Cells / cytology. Langerhans Cells / cytology

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  • (PMID = 19594558.001).
  • [ISSN] 1442-9071
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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28. Yokoi N, Inatomi T, Kinoshita S: Surgery of the conjunctiva. Dev Ophthalmol; 2008;41:138-58

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery of the conjunctiva.
  • In addition to the lacrimal gland, the meibomian gland, cornea, and conjunctiva also contribute to the formation of the tear film via the production of goblet-cellderived mucin and the expression of membrane-associated mucin.
  • The conjunctiva can be linked with dry eye through various mechanisms such as inflammation, disturbance of the tear film, and conjunctival fibrosis.
  • Thus, normalization of the conjunctiva is important for the management of dry eye.
  • MATERIALS AND METHODS: Conjunctival diseases associated with dry eye include conjunctivochalasis, superior limbic keratoconjunctivitis, pterygium and pinguecula, and severe ocular surface diseases such as Stevens-Johnson syndrome and ocular cicatricial pemphigoid.
  • The major concept of conjunctival surgery for dry eye is to smoothen the surface in order (1) to reduce blink-associated microtrauma, (2) to reconstruct the tear meniscus and conjunctival fornix and their respective functions as reservoirs for tears, and (3) to reduce conjunctival inflammation by the removal of abnormal fibrous tissue combined with the use of mitomycin C and/or amniotic membrane.
  • Therefore, the resection of redundant conjunctiva and abnormal tissue in pterygium is an effective procedure for normalizing the tear film.
  • If cicatrizing conjunctivitis results in tear-film instability due to conjunctival inflammation and squamous metaplasia, reconstruction of ocular surface epithelium is vital for its resolution.
  • CONCLUSION: In order to effectively manage dry eye due to conjunctival disease, it is important to understand not only the surgical procedure but also the pathomechanisms of conjunctival changes leading to signs and symptoms of tear-film deficiencies.
  • [MeSH-major] Conjunctiva / surgery. Conjunctival Diseases / surgery. Dry Eye Syndromes / surgery. Ophthalmologic Surgical Procedures

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  • (PMID = 18453766.001).
  • [ISSN] 0250-3751
  • [Journal-full-title] Developments in ophthalmology
  • [ISO-abbreviation] Dev Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 42
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29. Bielory L, Ghafoor S: Histamine receptors and the conjunctiva. Curr Opin Allergy Clin Immunol; 2005 Oct;5(5):437-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histamine receptors and the conjunctiva.
  • PURPOSE OF REVIEW: The purpose of this review is to evaluate the effect of histamine on various receptors in the conjunctiva.
  • A Medline search from 1980 was performed on the histamine receptor subtypes H1, H2 and H3 in the human conjunctiva.
  • RECENT FINDINGS: In the conjunctiva, histamine has been shown to induce various physiological and immunological changes through both H1 and H2 receptor stimulation.
  • Histamine binding to conjunctival H1 receptors through the phospholipase C-dependent inositol phosphate pathway leads to the symptom of pruritus while histamine stimulation of the conjunctival H2 receptors has been indirectly shown to cause vasodilation.
  • SUMMARY: The effect of histamine on conjunctival H1 receptors appears to be the primary target for ocular allergy treatment as it is primarily involved in ocular pruritus.
  • The exact interaction of the conjunctival H2 receptors appears to work in a complementary fashion to the H1 receptor in controlling other features of ocular allergy such as vasodilation and injection.
  • [MeSH-major] Conjunctiva / immunology. Conjunctivitis, Allergic / drug therapy. Conjunctivitis, Allergic / immunology. Histamine Antagonists / pharmacology. Receptors, Histamine / immunology

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  • (PMID = 16131920.001).
  • [ISSN] 1528-4050
  • [Journal-full-title] Current opinion in allergy and clinical immunology
  • [ISO-abbreviation] Curr Opin Allergy Clin Immunol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histamine Antagonists; 0 / Histamine H1 Antagonists; 0 / Histamine H2 Antagonists; 0 / Receptors, Histamine
  • [Number-of-references] 23
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30. Haefliger IO, Vysniauskiene I, Figueiredo AR, Piffaretti JM: Superficial conjunctiva cauterization to reduce moderate conjunctivochalasis. Klin Monbl Augenheilkd; 2007 Apr;224(4):237-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superficial conjunctiva cauterization to reduce moderate conjunctivochalasis.
  • On the inferior bulbar conjunctiva 10 to 20 superficial burns were performed with an electrical bipolar cauter to reduce moderate conjunctivochalasis.
  • RESULTS: In each patient, gentle and superficial cauterization induced contraction of the bulbar conjunctiva and reduction of the conjunctivochalasis.
  • CONCLUSIONS: Gentle superficial cauterization of the inferior bulbar conjunctiva can induced significant reduction of a moderate conjunctivochalasis.
  • [MeSH-major] Conjunctiva / pathology. Conjunctiva / surgery. Conjunctival Diseases / pathology. Conjunctival Diseases / surgery. Electrocoagulation / methods. Eyelid Diseases / pathology. Eyelid Diseases / surgery

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  • (PMID = 17458782.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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31. Cho SH, Na KS: Haemangioendothelioma on the conjunctiva of the upper eyelid. Clin Exp Ophthalmol; 2006 Nov;34(8):794-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Haemangioendothelioma on the conjunctiva of the upper eyelid.
  • A 62-year-old man visited the authors' clinic complaining of a mass on the palpebral conjunctiva of the right upper eyelid.
  • Herein, an unusual case of Kaposiform haemangioendothelioma affecting the conjunctiva of the upper eyelid on a middle-aged man is reported.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Eyelid Neoplasms / pathology. Hemangioendothelioma / pathology
  • [MeSH-minor] Administration, Oral. Biomarkers, Tumor / analysis. Glucocorticoids / therapeutic use. Humans. Male. Middle Aged. Prednisolone / therapeutic use

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  • (PMID = 17073904.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucocorticoids; 9PHQ9Y1OLM / Prednisolone
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32. Baumüller S, Kosanetzky N, Charbel Issa P, Holz FG, Löffler KU: [Vascular lesion of the conjunctiva]. Ophthalmologe; 2009 Sep;106(9):832-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vascular lesion of the conjunctiva].
  • [Transliterated title] Vaskuläre Läsion der Bindehaut.
  • Based on the results of the early indocyanine green angiography, MRI and sonography, a racemose hemangioma of the conjunctiva was diagnosed.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / therapy. Hemangioma / diagnosis. Hemangioma / therapy

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  • [Cites] Surv Ophthalmol. 2008 May-Jun;53(3):227-49 [18501269.001]
  • [Cites] Surv Ophthalmol. 2004 Jan-Feb;49(1):3-24 [14711437.001]
  • [Cites] Br J Ophthalmol. 2004 Aug;88(8):1092-3 [15258032.001]
  • [Cites] Acta Ophthalmol Scand. 2007 Nov;85(7):764-71 [17711544.001]
  • [Cites] Ophthalmology. 2004 Sep;111(9):1747-54 [15350332.001]
  • (PMID = 19557417.001).
  • [ISSN] 1433-0423
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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33. Berman EL, Shields CL, Sagoo MS, Eagle RC Jr, Shields JA: Multifocal blue nevus of the conjunctiva. Surv Ophthalmol; 2008 Jan-Feb;53(1):41-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multifocal blue nevus of the conjunctiva.
  • Blue nevus is a congenital benign melanocytic tumor that classically occurs in the skin and carries low potential for malignant transformation.
  • We report an unusual case of widely dispersed multifocal common blue nevus of the conjunctiva simulating conjunctival melanoma.
  • In conclusion, conjunctival blue nevus can be multifocal and masquerade as melanoma.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Nevus, Blue / pathology
  • [MeSH-minor] Biopsy. Cryosurgery / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Melanoma / diagnosis. Middle Aged

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  • (PMID = 18191656.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Charbel Issa P, Meyer-ter-Vehn T, Guthoff R, Klink T, Holz FG, Löffler K: [Malignant melanoma of the conjunctiva]. Klin Monbl Augenheilkd; 2008 Jul;225(7):663-6
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  • [Title] [Malignant melanoma of the conjunctiva].
  • [Transliterated title] Malignes Melanom der Bindehaut.
  • BACKGROUND: Malignant melanoma of the conjunctiva is a rare tumour.
  • Early disease stages may be difficult to distinguish from benign lesions such as pigmented nevi or primary acquired melanosis.
  • We describe the therapeutic procedure and histological findings in two patients and review the epidemiology and pathogenesis of malignant conjunctival melanoma.
  • Two female patients (84 and 85 years old, respectively) presented with a pigmented tumor close to the limbus with surrounding conjunctival pigmentation and involvement of the cornea.
  • RESULTS: Following complete excision of the tumour, conjunctival malignant melanoma arising from primary acquired melanosis was diagnosed histologically.
  • There was no recurrence of the tumor within the follow-up period (24 and 6 months).
  • [MeSH-major] Conjunctival Neoplasms / epidemiology. Conjunctival Neoplasms / pathology. Melanoma / epidemiology. Melanoma / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Incidence

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  • (PMID = 18642211.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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35. Pópulo H, Soares P, Rocha AS, Silva P, Lopes JM: Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma. Melanoma Res; 2010 Apr;20(2):107-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma.
  • It usually arises in the uvea, mostly in the choroid and less frequently in the conjunctiva.
  • The etiopathogenesis of uvea and conjunctiva melanomas is still poorly understood.
  • The aim of this study was to evaluate the contribution of the mTOR pathway in uvea and conjunctiva melanomas.
  • We analysed specific mTOR pathway effectors using immunohistochemical analysis of 30 uvea and eight conjunctiva melanoma samples.
  • In conjunctiva melanomas, overactivation of the mTOR pathway, as confirmed by high phospho-AKT Ser473 and Thr308, S6 and p4EBP1 Thr37/46 levels, was associated with adverse prognostic parameters (mitotic index and tumour thickness).
  • Conjunctiva melanomas displayed high expression of phospho-mTOR effectors in contrast with uvea melanomas, in which PTEN seemed to downregulate the mTOR pathway.
  • Characterizing the expression of PTEN, AKT and pS6 Ser235/236 might be a useful predictive tool for deciding whether to use mTOR inhibitors to treat conjunctiva melanomas.

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  • (PMID = 20173664.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases; EC 3.1.3.67 / PTEN Phosphohydrolase
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36. Boehlke CS, Frueh BR, Flint A, Elner VM: Malignant fibrous histiocytoma of the lateral conjunctiva and anterior orbit. Ophthal Plast Reconstr Surg; 2007 Jul-Aug;23(4):338-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant fibrous histiocytoma of the lateral conjunctiva and anterior orbit.
  • A 25-year-old woman presented for evaluation of a rapidly enlarging mass of the left bulbar conjunctiva.
  • Debulking biopsy was performed, which led to the diagnosis of myxoid malignant fibrous histiocytoma.
  • Histopathology showed involvement of the conjunctiva substantia propria, superior conjunctival fornix, and episclera, as well as extension from the lateral rectus muscle sheath.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Neoplasm Proteins / analysis. Ophthalmologic Surgical Procedures. Tomography, X-Ray Computed

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  • (PMID = 17667121.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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37. Owen CG, Newsom RS, Rudnicka AR, Barman SA, Woodward EG, Ellis TJ: Diabetes and the tortuosity of vessels of the bulbar conjunctiva. Ophthalmology; 2008 Jun;115(6):e27-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diabetes and the tortuosity of vessels of the bulbar conjunctiva.
  • OBJECTIVES: Diabetes is associated with loss of capillaries and macrovessel dilation in the conjunctiva, similar to well-known vessel changes in the retina.
  • However, little is known about the effect of diabetes on the tortuosity of vessels of the conjunctiva.
  • The authors examined the tortuosity of conjunctival vessels in participants with and without diabetes.
  • Increased tortuosity associated with diabetes among conjunctival capillaries mirrors established vessel changes observed in the retina.
  • Conjunctival angiopathy associated with diabetes may contribute to susceptibility to anterior eye disease among patients with diabetes.
  • [MeSH-major] Ciliary Arteries / physiopathology. Conjunctiva / blood supply. Diabetic Retinopathy / physiopathology. Peripheral Vascular Diseases / physiopathology

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  • (PMID = 18423868.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Messmer EM, Mackert MJ, Zapp DM, Kampik A: In vivo confocal microscopy of normal conjunctiva and conjunctivitis. Cornea; 2006 Aug;25(7):781-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo confocal microscopy of normal conjunctiva and conjunctivitis.
  • PURPOSE: To analyze the appearance of normal conjunctiva and conjunctival inflammation by in vivo confocal microscopy.
  • METHODS: Conjunctiva of 15 normal patients and 21 patients with conjunctivitis including bacterial, papillary, follicular, granulomatous, and cicatrizing disease were analyzed by the Heidelberg retina tomograph (HRTII)/Rostock cornea modul (RCM).
  • RESULTS: Scans of normal bulbar and tarsal conjunctiva corresponded well to the established anatomy except for a prominent, thickened epithelial basement membrane observed by in vivo microscopy.
  • Presumed goblet cells were visible throughout the conjunctival epithelium.
  • Adenoid structures and hair follicles were discernible in the tarsal conjunctiva in vivo.
  • Conjunctival perfusion could be observed directly.
  • Acute and chronic inflammatory cells, conjunctival papillary, and follicular reactions, as well as conjunctival cicatrization, could be discriminated.
  • In a patient with conjunctival granuloma, in vivo confocal microscopy disclosed suture material inside the lesion.
  • CONCLUSION: Confocal microscopy using near-infrared laser light is a useful new tool in the analysis of conjunctival tissue in vivo.
  • It is a valuable aid in the differential diagnosis of conjunctival inflammation and thus may guide therapeutical decisions.
  • [MeSH-major] Conjunctiva / cytology. Conjunctivitis / pathology

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  • (PMID = 17068454.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Reddy S, Finger PT, Kurli M, Bui A, Iacob CE: Conjunctival malignant melanoma-associated pseudomelanoma of the apposing tarsal conjunctiva. Cornea; 2006 Oct;25(9):1121-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival malignant melanoma-associated pseudomelanoma of the apposing tarsal conjunctiva.
  • PURPOSE: To describe a case of conjunctival malignant melanoma associated with pseudomelanomatous alteration of the apposing tarsal conjunctiva.
  • METHODS: A 93-year-old woman presented with an elevated, pigmented mass on her superior bulbar conjunctiva.
  • The tumor was associated with increased pigmentation of the apposing superior tarsal conjunctiva.
  • An excisional biopsy of the epibulbar melanoma and pigmented tarsal conjunctiva was performed.
  • RESULTS: Histopathologic evaluation of the epibulbar tumor revealed epithelioid melanocytes diagnostic of malignant melanoma.
  • CONCLUSION: Noncontiguous pigmented conjunctival tumor can be found in apposition to an epibulbar melanoma.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Eyelid Diseases / pathology. Melanoma / pathology. Melanosis / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Humans

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  • (PMID = 17133070.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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40. Fukushima A, Ozaki A, Ishida W, van Rooijen N, Fukata K, Ueno H: Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis. Cell Biol Int; 2005 Apr;29(4):277-86

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis.
  • Macrophages infiltrate the conjunctiva in severe cases of allergic conjunctivitis (AC) such as atopic keratoconjunctivitis (AKC).
  • We investigated whether macrophage infiltration in the conjunctiva in this EC model is inhibited by clodronate liposomes (CL2MDP-lip).
  • Intravenous injection of CL2MDP-lip decreased the number of ED2-positive cells in the conjunctiva.
  • Thus, we conclude that CL2MDP-lip inhibits infiltration of macrophages into the conjunctiva within 24 h of antigen challenge.

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  • (PMID = 15893479.001).
  • [ISSN] 1065-6995
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Liposomes; 0813BZ6866 / Clodronic Acid
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41. Steven P, Gebert A: Conjunctiva-associated lymphoid tissue - current knowledge, animal models and experimental prospects. Ophthalmic Res; 2009;42(1):2-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctiva-associated lymphoid tissue - current knowledge, animal models and experimental prospects.
  • The conjunctiva contains organized lymphoid tissue that consists of intraepithelial lymphocytes, subepithelial lymphoid follicles and adjacent lymphatics and blood vessels.
  • This conjunctiva-associated lymphoid tissue (CALT) is assumed to play a key role in the protection of the ocular surface by initiating and regulating immune responses.
  • [MeSH-major] Conjunctiva / physiology. Lymphoid Tissue / physiology. Models, Animal

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  • (PMID = 19478534.001).
  • [ISSN] 1423-0259
  • [Journal-full-title] Ophthalmic research
  • [ISO-abbreviation] Ophthalmic Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 64
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42. Westekemper H, Meller S, Citak S, Schulte C, Steuhl KP, Homey B, Meller D: Differential chemokine expression in chronic GVHD of the conjunctiva. Bone Marrow Transplant; 2010 Aug;45(8):1340-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential chemokine expression in chronic GVHD of the conjunctiva.
  • In chronic GVHD after BMT, the conjunctiva represents a target organ.
  • We examined the expression of chemokines in the conjunctiva in cases of chronic GVHD.
  • Clinical data were collected and tear film analysis and conjunctival cytology were carried out.
  • Conjunctival biopsies were taken from all participants.
  • Chronic GVHD of the conjunctiva is characterised by the expression of Th1-associated chemokines.
  • Taken together, our results confirm that the conjunctiva is a target organ in this T cell-mediated process and add to molecular understanding of conjunctival GVHD.
  • [MeSH-major] Bone Marrow Transplantation / adverse effects. Chemokines / analysis. Conjunctival Diseases / pathology. Graft vs Host Disease / pathology

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  • (PMID = 20140022.001).
  • [ISSN] 1476-5365
  • [Journal-full-title] Bone marrow transplantation
  • [ISO-abbreviation] Bone Marrow Transplant.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chemokines; 0 / Receptors, Chemokine
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43. Bonini S, Micera A, Iovieno A, Lambiase A, Bonini S: Expression of Toll-like receptors in healthy and allergic conjunctiva. Ophthalmology; 2005 Sep;112(9):1528; discussion 1548-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Toll-like receptors in healthy and allergic conjunctiva.
  • PURPOSE: To investigate the expression of toll-like receptors (TLRs) in healthy and active vernal keratoconjunctivitis (VKC) conjunctiva.
  • METHODS: Normal and VKC conjunctiva were evaluated for TLR-2, TLR-4, and TLR-9 mRNA and proteins by relative real-time polymerase chain reaction and immunohistochemistry.
  • RESULTS: Toll-like receptor 2, TLR-4, and TLR-9 were expressed in normal and VKC conjunctival epithelium and stroma, both with a more intense immunoreactivity in the stroma.
  • CONCLUSIONS: Toll-like receptors are expressed in healthy and allergic conjunctiva.
  • [MeSH-major] Conjunctiva / metabolism. Conjunctivitis, Allergic / metabolism. Membrane Glycoproteins / metabolism. Receptors, Cell Surface / metabolism

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  • (PMID = 16023216.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / TLR2 protein, human; 0 / TLR4 protein, human; 0 / TLR9 protein, human; 0 / Toll-Like Receptor 2; 0 / Toll-Like Receptor 4; 0 / Toll-Like Receptor 9; 0 / Toll-Like Receptors
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44. Efron N, Al-Dossari M, Pritchard N: In vivo confocal microscopy of the palpebral conjunctiva and tarsal plate. Optom Vis Sci; 2009 Nov;86(11):E1303-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo confocal microscopy of the palpebral conjunctiva and tarsal plate.
  • PURPOSE: The aim of this work is to develop a more complete understanding of the in vivo histology of the human palpebral conjunctiva and tarsal plate.
  • METHODS: The upper eyelids of 11 healthy human volunteer subjects were everted, and laser scanning confocal microscopy was used to examine the various tissue layers of the palpebral conjunctiva and tarsal plate.
  • Occasional conjunctival microcysts and Langerhans cells are observed.
  • CONCLUSIONS: Laser scanning confocal microscopy is capable of studying the human palpebral conjunctiva, tarsal plate, and acini of meibomian glands in vivo.
  • [MeSH-major] Conjunctiva / anatomy & histology. Eyelids / anatomy & histology. Microscopy, Confocal
  • [MeSH-minor] Adult. Blood Vessels / anatomy & histology. Conjunctival Diseases / pathology. Cysts / pathology. Epithelial Cells / cytology. Epithelium / anatomy & histology. Female. Humans. Langerhans Cells / cytology. Male. Meibomian Glands / anatomy & histology. Young Adult

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  • (PMID = 19770809.001).
  • [ISSN] 1538-9235
  • [Journal-full-title] Optometry and vision science : official publication of the American Academy of Optometry
  • [ISO-abbreviation] Optom Vis Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Lin J, Zhang P, Li Y, Zheng J, Zhong X, Zhang W, Nie L, Zhang B: [The comparison of HE staining and giemsa staining in detection of eosinophilic granulocytes in conjunctiva scroping]. Yan Ke Xue Bao; 2005 Jun;21(2):79-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The comparison of HE staining and giemsa staining in detection of eosinophilic granulocytes in conjunctiva scroping].
  • The infected palpabral conjunctiva of both eyes were scroped and stained separately with Giemsa staining and HE staining.

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  • (PMID = 17165333.001).
  • [ISSN] 1000-4432
  • [Journal-full-title] Yan ke xue bao = Eye science
  • [ISO-abbreviation] Yan Ke Xue Bao
  • [Language] CHI
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Azure Stains; 0 / Coloring Agents; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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46. Michels KS, Vagefi MR, Steele E, Zwick OM, Torres JJ, Seiff SR, Dailey RA: Müller muscle-conjunctiva resection to correct ptosis in high-risk patients. Ophthal Plast Reconstr Surg; 2007 Sep-Oct;23(5):363-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Müller muscle-conjunctiva resection to correct ptosis in high-risk patients.
  • PURPOSE: Müller muscle-conjunctiva resection could be seen as a relative contraindication in patients with a prior history of a glaucoma filtering procedure, corneal disease, or corneal surgery.
  • The concern centers around the theoretical risk of bleb-related complications or corneal damage from the palpebral conjunctival sutures.
  • Our study aimed to determine whether any bleb- or cornea-related complications arose in patients who underwent Müller muscle-conjunctiva resection for ptosis correction.
  • METHODS: A retrospective chart review was performed on 2 practices of oculofacial plastic surgeons from 2000 to 2006, including patients who had ptosis correction by Müller muscle-conjunctiva resection.
  • RESULTS: Forty-three patients and 55 eyes with a history of a glaucoma filtering procedure (13 patients/15 eyes), corneal disease (1 patient/1 eye), or corneal surgery (29 patients/39 eyes) who underwent Müller muscle-conjunctiva resection were identified.
  • CONCLUSIONS: Müller muscle-conjunctiva resection can provide an effective means for ptosis repair in patients with a prior history of a glaucoma filtering procedure, corneal disease, or corneal surgery.
  • [MeSH-major] Blepharoptosis / surgery. Conjunctiva / surgery. Oculomotor Muscles / surgery

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  • (PMID = 17881985.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Diebold Y, Enríquez de Salamanca A, Calonge M, Sáez V, Callejo S, Stern ME: Alpha2-adrenergic receptors are present in normal human conjunctiva. Curr Eye Res; 2005 Dec;30(12):1121-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alpha2-adrenergic receptors are present in normal human conjunctiva.
  • PURPOSE: Despite the passage of medications, including antiglaucoma drugs, through the ocular surface, and despite the increasing relevance of neurogenic inflammation in the ocular surface, the presence of some neuroreceptors in the conjunctiva has not been ascertained.
  • This study describes the presence of alpha2-adrenergic receptors in normal human conjunctiva.
  • METHODS: Immunofluorescence microscopy, electrophoresis, and Western blot analyses were done in human conjunctival biopsies and rat control tissues.
  • RESULTS: Immunoreactivity for alpha2A- and alpha2B-, but not alpha2C-adrenergic receptors was evenly distributed in epithelial cells of human conjunctiva cryosections.
  • CONCLUSIONS: Normal human conjunctival epithelial cells express alpha2A-, alpha2B-, and alpha2C-adrenergic receptors.
  • [MeSH-major] Conjunctiva / metabolism. Receptors, Adrenergic, alpha-2 / metabolism

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  • (PMID = 16354626.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Adrenergic, alpha-2
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48. Mochizuki K, Yamada T, Mori Y, Sawada A, Mori I, Ohnishi Y: Case of atypical fibroxanthoma in the palpebral conjunctiva. Jpn J Ophthalmol; 2008 Sep-Oct;52(5):404-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case of atypical fibroxanthoma in the palpebral conjunctiva.
  • BACKGROUND: We report a case of atypical fibroxanthoma that developed in the palpebral conjunctiva.
  • CASE: A 94-year-old woman had a hemorrhagic tumor in the right lower palpebral conjunctiva that was resected, and adjunctive cryotherapy was applied to the surgical bed.
  • OBSERVATIONS: The tumor was bleeding and appeared as a pale red, elastic but firm nodule approximately 15x16x8 mm in size.
  • The tumor stained positive for vimentin, CD68, and CD10, weakly for CD74 and CD99, and was negative for keratin (wide), KL-1, alpha-fetoprotein, myoglobin, S-100, alpha-smooth muscle actin, desmin, leukocyte common antigen, and glial fibrillary acidic protein immunohistochemically.
  • From these findings, we diagnosed the tumor as an atypical fibroxanthoma.
  • CONCLUSIONS: An atypical fibroxanthoma in the palpebral conjunctiva is very rare.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / analysis. Conjunctival Diseases. Cryosurgery. Female. Humans. Neoplasm Proteins / analysis. Xanthomatosis

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  • [Cites] J Cutan Pathol. 2007 May;34(5):415-9 [17448198.001]
  • [Cites] Australas J Dermatol. 2004 May;45(2):106-9 [15068457.001]
  • [Cites] J Cutan Pathol. 2006 Sep;33 Suppl 2:24-8 [16972949.001]
  • [Cites] Arch Ophthalmol. 1991 Jul;109(7):922-3 [2064569.001]
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  • [Cites] Ophthal Plast Reconstr Surg. 2005 Mar;21(2):103-8 [15778662.001]
  • (PMID = 18991043.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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49. Kobayashi A, Yoshita T, Sugiyama K: In vivo findings of the bulbar/palpebral conjunctiva and presumed meibomian glands by laser scanning confocal microscopy. Cornea; 2005 Nov;24(8):985-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo findings of the bulbar/palpebral conjunctiva and presumed meibomian glands by laser scanning confocal microscopy.
  • OBJECTIVE: To report in vivo laser scanning confocal microscopic findings of the normal human conjunctiva and presumed meibomian glands and to investigate the potential application of this confocal microscope (HRT II Rostock Cornea Module) as a diagnostic device for normal and abnormal ocular surface structures.
  • The temporal bulbar conjunctiva, approximately 5 mm away from the limbus, and the upper tarsus conjunctiva of each patient were examined in vivo by a laser confocal microscope.
  • Also, presumed meibomian glands beneath the tarsal conjunctiva were examined.
  • In the superficial epithelial cell layer of the bulbar conjunctiva, numerous bright nuclei were observed.
  • We also observed many Langerhans cells with characteristic dendritic morphology and goblet cells with relatively homogeneous brightness in the bulbar conjunctiva.
  • Most interestingly, the palpebral conjunctival epithelium with invaginations or crypts was observed.
  • In addition, weblike structures, presumably meibomian glands, were observed beneath the palpebral conjunctival epithelium.
  • CONCLUSIONS: These results indicate that in vivo laser confocal microscopy can be used not only to visualize the bulbar conjunctiva but the upper tarsus conjunctiva and possibly subconjunctival meibomian glands.
  • Further investigations of conjunctival and meibomian gland pathologies may further elucidate the potential of this device in clinical ophthalmology.
  • [MeSH-major] Conjunctiva / ultrastructure. Meibomian Glands / ultrastructure

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  • (PMID = 16227847.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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50. Shin YJ, Lee HI, Kim MK, Wee WR, Lee JH, Koh JH, Lee HJ, Lee JL, Min BM, Sohn YS, Kim HY: Biocompatibility of nanocomposites used for artificial conjunctiva: in vivo experiments. Curr Eye Res; 2007 Jan;32(1):1-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biocompatibility of nanocomposites used for artificial conjunctiva: in vivo experiments.
  • PURPOSE: To evaluate the biocompatibility of nanocomposites used for artificial conjunctiva.
  • The disks were inserted underneath the conjunctiva to measure their inflammation-inducing properties.
  • To investigate epithelial adhesion and goblet cell differentiation, the disks were transplanted after round conjunctival excision.
  • Cultivated conjunctival epithelial cells on nanocomposite were then transplanted onto the abdomen of Balb/c athymic mice.
  • The reepithelialization of conjunctival cells was accomplished in more than 75% of all disks except for the PCL+C.
  • CONCLUSIONS: Nanocomposites of PCL were biocompatible in rabbit conjunctiva, suggesting that PCL may be considered as a candidate for use in the development of artificial conjunctiva.
  • [MeSH-major] Artificial Organs. Caproates. Coated Materials, Biocompatible. Conjunctiva / surgery. Lactones. Nanocomposites

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  • (PMID = 17364729.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Caproates; 0 / Coated Materials, Biocompatible; 0 / Lactones; 502-44-3 / caprolactone; 9002-89-5 / Polyvinyl Alcohol; 9003-39-8 / Povidone; 9012-76-4 / Chitosan
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51. Foster JA, Holck DE, Perry JD, Wulc AE, Burns JA, Cahill KV, Morgenstern KE: Fibrin sealant for Müller muscle-conjunctiva resection ptosis repair. Ophthal Plast Reconstr Surg; 2006 May-Jun;22(3):184-7
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  • [Title] Fibrin sealant for Müller muscle-conjunctiva resection ptosis repair.
  • PURPOSE: To determine the safety and efficacy of fibrin sealant for use in Müller muscle-conjunctiva resection ptosis repair.
  • All patients underwent Müller muscle-conjunctiva resection ptosis repair with fibrin sealant used for wound closure.
  • RESULTS: Müller muscle-conjunctiva resection ptosis repair with fibrin sealant used for wound closure was performed on 53 eyelids of 33 patients.
  • CONCLUSIONS: Müller muscle-conjunctiva resection ptosis repair with fibrin sealant used for wound closure may allow for predictable results with few complications and appears to be an acceptable alternative to traditional suture techniques.
  • [MeSH-major] Blepharoptosis / surgery. Conjunctiva / surgery. Eyelids / surgery. Fibrin Tissue Adhesive / therapeutic use. Oculomotor Muscles / surgery. Ophthalmologic Surgical Procedures. Tissue Adhesives / therapeutic use. Wound Healing / drug effects

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  • (PMID = 16714926.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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52. Cain C, Phillips TE: Developmental changes in conjunctiva-associated lymphoid tissue of the rabbit. Invest Ophthalmol Vis Sci; 2008 Feb;49(2):644-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Developmental changes in conjunctiva-associated lymphoid tissue of the rabbit.
  • PURPOSE: Organized conjunctiva-associated lymphoid tissue (O-CALT) is constantly exposed to environmental antigens and plays a central role in the common mucosal immune system.
  • METHODS: Fluorescence stereomicroscopy was used to measure the number and size of conjunctival follicles stained with propidium iodide in rabbits ranging in age from 2 days to 57 months.
  • This disappearance was most pronounced in the superior conjunctiva.
  • Average follicle diameter increased with age, except in the superior conjunctiva of aged rabbits, where the few remaining follicles were generally smaller.
  • CONCLUSIONS: Age-related changes in rabbit O-CALT are similar to those that have been reported for the human conjunctiva.
  • [MeSH-major] Aging / physiology. Conjunctiva / cytology. Lymphoid Tissue / cytology

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  • (PMID = 18235010.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 13779; United States / NIGMS NIH HHS / GM / GM 56901-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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53. Nadri S, Soleimani M, Kiani J, Atashi A, Izadpanah R: Multipotent mesenchymal stem cells from adult human eye conjunctiva stromal cells. Differentiation; 2008 Mar;76(3):223-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multipotent mesenchymal stem cells from adult human eye conjunctiva stromal cells.
  • This work focused on characterizing a new source of MSCs from stromal cells from human eye conjunctiva.
  • In this study, after conjunctiva biopsies and culture of stromal segment of this tissue, fibroblast-like (SH2+, SH3+, CD29+, CD44+, CD166+, CD13+) human stromal cells, which can be differentiated toward the osteogenic, adipogenic, chondrogenic, and neurogenic lineages, were obtained.
  • Taken together, the results indicate that conjunctiva stromal-derived cells are a new source of multipotent MSCs and despite originating from an adult source, they express undifferentiated stem cell markers.
  • [MeSH-major] Conjunctiva / cytology. Mesenchymal Stromal Cells / cytology. Multipotent Stem Cells / cytology. Stromal Cells / cytology

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  • (PMID = 17825086.001).
  • [ISSN] 1432-0436
  • [Journal-full-title] Differentiation; research in biological diversity
  • [ISO-abbreviation] Differentiation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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54. Gaton DD, Lichter H, Avisar I, Slodovinic D, Solomon AS: Lymphocytic reaction to ultraviolet radiation on rabbit conjunctiva. Ann Ophthalmol (Skokie); 2007;39(2):128-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphocytic reaction to ultraviolet radiation on rabbit conjunctiva.
  • We examined the clinical and histological effects of controlled UV radiation on the conjunctiva and cornea of rabbit eyes by duration of exposure (0.5-4 hours daily for 5 consecutive days).
  • Longer UV exposure (day 1-day 5) was associated with increased conjunctival redness, corneal erosion, edema and opacity.
  • [MeSH-major] Conjunctiva / pathology. Conjunctiva / radiation effects. Cornea / pathology. Cornea / radiation effects. Lymphocytes / pathology. Ultraviolet Rays / adverse effects
  • [MeSH-minor] Animals. Cataract / etiology. Conjunctival Diseases / etiology. Conjunctival Diseases / pathology. Corneal Diseases / etiology. Corneal Diseases / pathology. Corneal Edema / etiology. Dose-Response Relationship, Radiation. Rabbits. Severity of Illness Index. Time Factors

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  • (PMID = 17984501.001).
  • [ISSN] 1558-9951
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Lorenzini PF, Picoli SU: [Aerobic bacterial microbiota of the conjunctiva of cornea donors]. Arq Bras Oftalmol; 2007 Mar-Apr;70(2):229-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Aerobic bacterial microbiota of the conjunctiva of cornea donors].
  • [Transliterated title] Microbiota bacteriana aeróbia da conjuntiva de doadores de córnea.
  • PURPOSE: To determine aerobic bacterial microbiota of the conjunctiva of cornea donors and its patterns of susceptibility to antibiotics; verify the number of corneas used for transplant and the average time of preservation in solutions with gentamicin and streptomycin; trace the profile of donors and receptors of cornea.
  • METHODS: Clinical specimens were collected from the inferior bag of the conjunctiva of both eyes of 40 cornea donors.
  • RESULTS: The frequency of positive cultures of the conjunctiva of cornea donors was 72.5%, with Gram-positive totalling 81.6% and only 18.4% of the samples were identified as Gram-negative.
  • [MeSH-major] Bacteria, Aerobic. Conjunctiva / microbiology. Tissue Donors

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  • (PMID = 17589692.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Gentamicins; 6Q205EH1VU / Vancomycin; Y45QSO73OB / Streptomycin
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56. Efron N, Al-Dossari M, Pritchard N: Confocal microscopy of the bulbar conjunctiva in contact lens wear. Cornea; 2010 Jan;29(1):43-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Confocal microscopy of the bulbar conjunctiva in contact lens wear.
  • PURPOSE: The aim of this study was to investigate the capabilities of laser scanning confocal microscopy (LSCM) for undertaking qualitative and quantitative investigations of the response of the bulbar conjunctiva to contact lens wear.
  • METHODS: LSCM was used to observe and measure morphological characteristics of the bulbar conjunctiva of 11 asymptomatic soft contact lens wearers and 11 healthy volunteer subjects (controls).
  • RESULTS: The appearance of the bulbar conjunctiva is consistent with known histology of this tissue based on light and electron microscopy.
  • The thickness of the bulbar conjunctival epithelium of lens wearers (30.9 +/- 1.1 microm) was less than that of controls (32.9 +/- 1.1 microm) (P < 0.0001).
  • Superficial and basal bulbar conjunctival epithelial cell densities in contact lens wearers were 91% and 79% higher, respectively, than that in controls (P < 0.0001).
  • Conjunctival microcysts were observed in greater numbers, and were larger in size, in lens wearers compared with controls.
  • CONCLUSIONS: The effects of contact lens wear on the human bulbar conjunctiva can be investigated effectively at a cellular level using LSCM.
  • The observations in this study suggest that contact lens wear can induce changes in the bulbar conjunctiva such as epithelial thinning and accelerated formation and enlargement of microcysts, increased epithelial cell density, but has no impact on goblet or Langerhans cell density.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Diseases / diagnosis. Contact Lenses / adverse effects. Cysts / diagnosis. Epithelial Cells / pathology

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  • (PMID = 19907292.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Yang H, Xiang Y, Zhang XN: [Experimental study on the effects of chitosan on the conjunctiva scar formation and symblepharon]. Zhonghua Yan Ke Za Zhi; 2006 Apr;42(4):313-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experimental study on the effects of chitosan on the conjunctiva scar formation and symblepharon].
  • OBJECTIVE: To study the effects of chitosan on preventing symblepharon, reducing conjunctiva scar formation and promoting epithelial healing in the treatment of keratoconjunctival alkali burn.
  • The symblepharon, conjunctiva scar formation and the inflammatory reaction of cornea and conjunctiva were observed by slit lamp.
  • The amount of collagen in the conjunctiva and the scar formation process was evaluated by sirius red staining 30 d after alkali burn.
  • RESULTS: The degrees of the symblepharon and conjunctiva scar formation in the treatment group were less than those in the experimental control group (u = 2.1159, P < 0.05).
  • The amount of collagen in the conjunctiva was increased and the conjunctiva scar was formed after alkali burn, but the amount of collagen, which was evaluated by the area (Q = 32.1450, P < 0.01) and integral spectra (Q = 22.4767, P < 0.01) of sirius red staining in the treatment group was much lower than that of the experimental control group.
  • [MeSH-major] Biocompatible Materials / pharmacology. Chitosan / pharmacology. Cicatrix / prevention & control. Conjunctival Diseases / prevention & control. Eye Burns / complications

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  • (PMID = 16762207.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 9012-76-4 / Chitosan
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58. Svidovyĭ VI, Gazizova IR: [Evaluating microcirculation state in eye conjunctiva of machinery construction industry workers]. Med Tr Prom Ekol; 2008;(5):45-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evaluating microcirculation state in eye conjunctiva of machinery construction industry workers].
  • The authors studied changes in microcirculatory vessels of conjunctiva, through biomicroscopy and calibrometric angiographic parameters in the examinees, and determined significant changes - narrowed arterioles, RBC aggreggation sites - in the workers with long length of service.

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  • (PMID = 18589905.001).
  • [ISSN] 1026-9428
  • [Journal-full-title] Meditsina truda i promyshlennaia ekologiia
  • [ISO-abbreviation] Med Tr Prom Ekol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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59. Motoishi M, Enokibori T, Katsuki Y, Tsuchiya M, Hatakenaka R: Mucosa-associated lymphoid tissue lymphoma involving lung and conjunctiva. Gen Thorac Cardiovasc Surg; 2008 May;56(5):246-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucosa-associated lymphoid tissue lymphoma involving lung and conjunctiva.
  • A 68-year-old man was found to have tumors of the left lung and left conjunctiva.
  • Histological examination revealed diffuse proliferations of centrocyte-like cells with lymphoepithelial lesions, and a diagnosis of mucosa-associated lymphoid tissue (MALT) lymphoma was made.
  • Conjunctival tumor biopsy was performed and the diagnosis was confirmed.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Lung Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology

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  • (PMID = 18470693.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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60. Alkatan HM, Al-Motlak MA, Al-Shedoukhy AA: Metastatic Squamous Spindle Cell Carcinoma of the conjunctiva. Saudi J Ophthalmol; 2010 Oct;24(4):155-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic Squamous Spindle Cell Carcinoma of the conjunctiva.
  • Conjunctival Squamous Cell Carcinoma (CSCC) is one of the important ocular surface tumors.
  • A single case of spindle squamous cell carcinoma tumor-related death due to bone and lung metastasis has been reported in Sweden in 1995.
  • We are reporting a similar case of SSCC of the conjunctiva with eventual death because of bilateral lung metastasis in our area.
  • Proper identification of this type of tumor by ocular pathologists and the need for future detailed clinicopathologic studies on CSCC in Saudi Arabia is emphasized.

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  • (PMID = 23960894.001).
  • [ISSN] 1319-4534
  • [Journal-full-title] Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
  • [ISO-abbreviation] Saudi J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3729720
  • [Keywords] NOTNLM ; Conjunctiva / Metastasis / Squamous Spindle Cell Carcinoma
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61. Yaman A, Ozbek Z, Saatci AO, Durak I, Lebe B: Topical steroids in the management of Churg-Strauss syndrome involving the conjunctiva. Cornea; 2007 May;26(4):498-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Topical steroids in the management of Churg-Strauss syndrome involving the conjunctiva.
  • PURPOSE: To discuss a case of Churg-Strauss syndrome that developed bilateral conjunctival involvement while recovering from miliary tuberculosis.
  • The diagnosis was confirmed by liver biopsy.
  • He had bilateral irregular, pink-yellow, gravel-like infiltrations involving the bulbar conjunctiva.
  • Biopsy revealed granulomas with central fibrinoid necrosis, histiocytes, and eosinophils, suggestive of conjunctival involvement of Churg-Strauss syndrome.
  • CONCLUSIONS: Churg-Strauss syndrome may rarely involve the conjunctiva, and conjunctival lesions respond favorably to topical steroids.
  • [MeSH-major] Churg-Strauss Syndrome / drug therapy. Conjunctival Diseases / drug therapy. Dexamethasone / administration & dosage. Glucocorticoids / administration & dosage

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  • (PMID = 17457205.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Glucocorticoids; 0 / Ophthalmic Solutions; 7S5I7G3JQL / Dexamethasone
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62. Zhu WQ, Xu JJ, Sun XH, Zheng TY, Le QH: [Normal human bulbar conjunctiva on confocal microscopy in vivo]. Zhonghua Yan Ke Za Zhi; 2009 Apr;45(4):344-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Normal human bulbar conjunctiva on confocal microscopy in vivo].
  • OBJECTIVE: To analyze the morphology of human bulbar conjunctiva by in vivo laser scanning confocal microscopy.
  • In vivo laser scanning confocal microscopic examinations were performed on the superior, inferior, nasal and temporal bulbar conjunctiva and the images were recorded.
  • The morphology of bulbar conjunctiva was analyzed and the density of epithelial cells, dendritic cells and goblet cells were calculated.
  • RESULTS: Superficial epithelial cells of bulbar conjunctiva were characterized as large loose-arranged cells with a hyporeflective nucleus.
  • There was a significant difference among three kinds of conjunctival epithelium (F = 1160.312, P = 0.000).
  • The dendritic cell appeared to be hyperreflective corpuscular particles with dendritic processes scattered among conjunctival epithelial cells.
  • Bulbar conjunctival substantia propria, beneath the basement membrane, was mainly composed of highly vascularized, loose connective tissues which were irregularly arranged fibers or a network of fibers, punctiform hyperreflective immune cells and sharp flows of blood vessels.
  • CONCLUSION: In vivo laser scanning confocal microscopy is a useful tool in the analysis of the bulbar conjunctival morphology, which provided a fast and noninvasive method for the diagnosis of ocular surface diseases.
  • [MeSH-major] Conjunctiva / anatomy & histology. Microscopy, Confocal / methods

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  • (PMID = 19575968.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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63. Yamanaka O, Saika S, Ohnishi Y, Kim-Mitsuyama S, Kamaraju AK, Ikeda K: Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice. Mol Vis; 2007;13:1730-9
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  • [Title] Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice.
  • PURPOSE: To examine the effects of blocking p38 mitogen-activated protein kinase (MAPK) on post-injury conjunctival scarring in mice.
  • A circumferential incision was made in the equatorial conjunctiva by scissors in the right eye of generally anesthetized adult C57BL/6 mice.
  • RESULTS: The in vivo DN-p38MAPK gene introduction blocked the phospho-p38 expression with reduction of myofibroblast generation and suppression of mRNA expression of connective tissue growth factor (CTGF) and monocyte/macrophage chemoattractant protein-1 (MCP-1) in the mouse-injured conjunctiva.
  • [MeSH-major] Cicatrix / prevention & control. Conjunctiva / enzymology. Conjunctiva / injuries. Wound Healing. Wounds, Penetrating / enzymology. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors

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  • (PMID = 17960111.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; 0 / CTGF protein, human; 0 / Collagen Type I; 0 / Ctgf protein, mouse; 0 / Enzyme Inhibitors; 0 / Extracellular Matrix Proteins; 0 / Imidazoles; 0 / Immediate-Early Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Pyridines; 0 / Smad Proteins; 0 / alpha 2(I) collagen; 139568-91-5 / Connective Tissue Growth Factor; 9007-34-5 / Collagen; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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64. Looi A, Kazim M, Cortes M, Rootman J: Orbital reconstruction after eyelid- and conjunctiva-sparing orbital exenteration. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):1-6
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  • [Title] Orbital reconstruction after eyelid- and conjunctiva-sparing orbital exenteration.
  • PURPOSE: To describe the technique and results of eyelid- and conjunctiva-sparing orbital exenteration with temporalis transfer and dermis-fat graft.
  • CONCLUSIONS: Eyelid- and conjunctiva-sparing orbital exenteration with temporalis transfer and dermis-fat graft is a useful technique that minimizes the usual deformity and achieves good results.
  • Case selection is emphasized, as this technique is mainly reserved for histopathologically benign orbital lesions that exhibit local aggressive behavior and for malignant lesions only if there is no eyelid, lacrimal gland, or orbital fissure involvement nor significant conjunctival or deep extension of an intraocular tumor.
  • [MeSH-major] Conjunctiva / surgery. Eyelids / surgery. Orbit Evisceration. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 16418657.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Mondal SK: Mucosa-associated lymphoid tissue lymphoma in conjunctiva. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):407-8
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  • [Title] Mucosa-associated lymphoid tissue lymphoma in conjunctiva.
  • A case of primary mucosa-associated lymphoid tissue (MALT) lymphoma (marginal zone B-cell lymphoma of MALT according to WHO classification) in conjunctiva, which presented as a slowly growing salmon-colored mass at limbus of left eye is reported.
  • Immunohistochemical analysis using monoclonal antibodies showed that the tumor cells are leukocyte common antigen (CD45)+, CD20+, CD3-, CD5-, CD10- and CD43-, which confirmed the B-cell lineage of lymphoma.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, B-Cell, Marginal Zone / pathology
  • [MeSH-minor] Antigens, CD / analysis. Biomarkers, Tumor / analysis. Humans. Limbus Corneae / pathology. Male. Middle Aged

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  • (PMID = 18723973.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor
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66. Fukushima A, Yamaguchi T, Ozaki A, Taniguchi T, Udaka K, Ueno H: Fyn regulates eosinophil infiltration into the conjunctiva by downregulating the Th2 response. Graefes Arch Clin Exp Ophthalmol; 2005 Oct;243(10):1043-9
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  • [Title] Fyn regulates eosinophil infiltration into the conjunctiva by downregulating the Th2 response.
  • RESULTS: Infiltration of eosinophils into the conjunctiva induced by active immunization was significantly increased in fyn-/- mice relative to WT mice.
  • CONCLUSIONS: Fyn regulates infiltration of eosinophils into the conjunctiva through downregulation of Th2 responses.
  • [MeSH-major] Conjunctiva / pathology. Conjunctivitis, Allergic / immunology. Down-Regulation / physiology. Eosinophils / pathology. Proto-Oncogene Proteins c-fyn / pharmacology. Th2 Cells / immunology

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  • [Cites] Annu Rev Immunol. 1994;12:635-73 [7912089.001]
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  • (PMID = 15838661.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Interleukin-5; 207137-56-2 / Interleukin-4; 37341-29-0 / Immunoglobulin E; EC 2.7.10.2 / Fyn protein, mouse; EC 2.7.10.2 / Proto-Oncogene Proteins c-fyn
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67. Gulias-Cañizo R, Aranda-Rábago J, Rodríguez-Reyes AA: [Seborrheic keratosis of conjunctiva: a case report]. Arch Soc Esp Oftalmol; 2006 Apr;81(4):217-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Seborrheic keratosis of conjunctiva: a case report].
  • [Transliterated title] Queratosis seborreica de la conjuntiva: informe de un caso.
  • CASE REPORT: Pigmented conjunctival lesions are a diagnostic challenge for the clinician.
  • A 37-year-old man presented with a pigmented mass involving the conjunctiva of his right eye.
  • Clinically, a diagnosis of malignant melanoma was made and a wide excision of the tumor was performed.
  • The histopathologic diagnosis was seborrheic keratosis.
  • DISCUSSION: Seborrheic keratosis is a benign lesion which occurs on the eyelids and face of middle-aged and elderly individuals.
  • The occurrence of this lesion on the conjunctiva is rare, however there are 2 cases reported in the world literature.
  • Seborrheic keratosis should be considered in the differential diagnosis of conjunctival pigmented lesions.
  • [MeSH-major] Conjunctival Diseases / pathology. Keratosis, Seborrheic / pathology
  • [MeSH-minor] Adult. Conjunctiva / pathology. Conjunctiva / surgery. Humans. Male. Ophthalmologic Surgical Procedures

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  • (PMID = 16688646.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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68. Söker S, Nergiz Y, Cakmak S, Bahçeci S, Aytekin S: The demonstration of changes in bulbar conjunctiva surface epithelium in the psoriatic patients treated with PUVA. Ann Ophthalmol (Skokie); 2008;40(2):94-8
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  • [Title] The demonstration of changes in bulbar conjunctiva surface epithelium in the psoriatic patients treated with PUVA.
  • We investigated the effects of disease itself and PUVA treatment on surface epithelium of conjunctiva in psoriatic patients (PP) before PUVA and after PUVA therapy and in 32 healthy volunteers.
  • [MeSH-major] Conjunctiva / drug effects. Conjunctival Diseases / chemically induced. Goblet Cells / drug effects. PUVA Therapy / adverse effects. Psoriasis / drug therapy

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  • (PMID = 19013916.001).
  • [ISSN] 1530-4086
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Kiratli H, Poyraz C, Gököz A: Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia. Cornea; 2007 Oct;26(9):1136-7
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  • [Title] Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia.
  • PURPOSE: To describe a patient with a sebaceous adenoma of the bulbar conjunctiva, a distinctly unusual site for this tumor, associated with glioblastoma multiforme and chronic lymphocytic leukemia.
  • METHODS: A 69-year-old woman presented with a red nodule on the temporal bulbar conjunctiva.
  • RESULTS: Histopathologic examination of the tumor showed a sebaceous adenoma.
  • The patient died 5 months after the ocular diagnosis because of cardiovascular complications.
  • CONCLUSIONS: Sebaceous adenoma is an exceedingly rare tumor of the bulbar conjunctiva and may be associated with several systemic malignancies.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Brain Neoplasms / pathology. Conjunctival Neoplasms / pathology. Glioblastoma / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17893552.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Yamagami S, Yokoo S, Amano S, Ebihara N: Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva. Invest Ophthalmol Vis Sci; 2007 Oct;48(10):4476-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva.
  • METHODS: Normal human donor corneas with attached conjunctiva were examined by fluorescence microscopy after single and double staining for multiple markers.
  • CD68(+) cells were separated from the conjunctival tissues by using magnetic beads, and the expression of toll-like receptor (TLR) 2 and TLR4 was examined.
  • RESULTS: CD45(+) cells were detected in the substantia propria of the conjunctiva, and approximately 60% of these cells were CD68(+).
  • CD68(+) cells isolated from conjunctival tissues expressed TLR2 and TLR4 on flow cytometry.
  • Macrophage mannose receptor CD206 was expressed by BMCs in the substantia propria of the conjunctiva, but not by BMCs in the corneal stroma or epithelium.
  • CONCLUSIONS: These findings demonstrated that the main population of BMCs in the substantia propria of normal human conjunctiva is CD68(+)CD14(+)HLA-DR(+) cells.
  • [MeSH-major] Biomarkers / metabolism. Bone Marrow Cells / cytology. Conjunctiva / cytology. Leukocytes / cytology

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  • (PMID = 17898268.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD14; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers; 0 / CD68 antigen, human; 0 / HLA-DR Antigens; 0 / Lectins, C-Type; 0 / Mannose-Binding Lectins; 0 / Receptors, Cell Surface; 0 / Receptors, Scavenger; 0 / TLR2 protein, human; 0 / TLR4 protein, human; 0 / Toll-Like Receptor 2; 0 / Toll-Like Receptor 4; 0 / mannose receptor
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71. Motegi S, Tamura A, Matsushima Y, Nagai Y, Ishikawa O: Squamous cell carcinoma of the eyelid arising from palpebral conjunctiva. Eur J Dermatol; 2006 Mar-Apr;16(2):187-9
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  • [Title] Squamous cell carcinoma of the eyelid arising from palpebral conjunctiva.
  • We reported a 58-year-old Japanese man with squamous cell carcinoma (SCC) of the left upper eyelid arising from the palpebral conjunctiva.
  • The tumor had been incised by a former doctor under the diagnosis of chalazion.
  • Histopathological examination of the relapsed tumor revealed atypical squamous cells invading towards the eyelid skin from the epithelium of palpebral conjunctiva.
  • We performed a total resection of the tumor and reconstructed the upper eyelid by the technique of Mustarde's switch flap.
  • SCC of the palpebral conjunctiva is quite rare, however, it often resembles chronic conjunctivitis or chalazion.
  • It is important to consider the possibility of SCC in addition to sebaceous carcinoma when we see a patient with an eyelid lesion, even one which looks like a benign condition such as chronic conjunctivitis or chalazion.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Conjunctiva. Eyelid Neoplasms / pathology

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  • (PMID = 16581575.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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72. Bekibele CO, Baiyeroju AM, Olusanya BA, Ashaye AO, Oluleye TS: Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft. Eye (Lond); 2008 Jan;22(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft.
  • BACKGROUND: The use of conjunctiva autograft, adjunct antimetabolite therapy has been shown to be effective in preventing pterygium recurrence.
  • OBJECTIVE: To compare 5 fluorouracil (5-FU) to conjunctival autograft in the treatment of large, fleshy pterygium.
  • METHODS: A randomised controlled prospective study of outcome of pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft.
  • Thirty-five eyes with large pterygium treated with bare sclera conjunctival excision plus 5-FU were compared with 33 eyes treated with excision and conjunctival autograft alone.
  • RESULTS: Post-operative pterygium recurrence was observed in four (11.4%) eyes treated with 5-FU and 4 (12.1%) eyes treated with conjunctiva autograft (P>0.05).
  • The post-operative complications included, granuloma formation 11.4% for 5-FU and 3.0% for autograft and conjunctival discharge 5.7% for 5-FU group only.
  • CONCLUSION: 5-FU is marginally superior to conjunctival autograft in the prevention of pterygium recurrence but neither gives a more desirable single digit recurrence rate.
  • Randomised studies combining both conjunctival autograft and 5-FU in pterygium treatment is advocated to further explore their effect.
  • [MeSH-major] Antimetabolites / therapeutic use. Conjunctiva / transplantation. Fluorouracil / therapeutic use. Pterygium / therapy

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  • (PMID = 16778821.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites; U3P01618RT / Fluorouracil
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73. Yazici B: Use of conjunctiva-Müller muscle pedicle flap in surgical treatment of necrotizing scleritis. Ophthal Plast Reconstr Surg; 2008 Jan-Feb;24(1):19-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of conjunctiva-Müller muscle pedicle flap in surgical treatment of necrotizing scleritis.
  • METHODS: The surgical technique involved placing an autologous fascia lata graft over the scleral defect and covering the graft with an inferiorly based conjunctiva-Müller muscle pedicle flap from the upper eyelid.
  • In both cases, the eye integrity was preserved after repair with conjunctiva-Müller muscle flap, and postoperative visual acuity improved.
  • CONCLUSION: Conjunctiva-Müller muscle pedicle flap may provide efficient and safe scleral repair in eyes with necrotizing scleritis.
  • [MeSH-major] Conjunctiva / surgery. Fascia Lata / transplantation. Oculomotor Muscles / surgery. Scleritis / surgery. Surgical Flaps

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  • (PMID = 18209635.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Lin SM, Ferrucci S: Primary acquired melanosis of the conjunctiva. Optometry; 2006 May;77(5):223-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary acquired melanosis of the conjunctiva.
  • BACKGROUND: Primary acquired melanosis (PAM) presents as a unilateral patchy area of conjunctival pigmentation mostly found in middle-aged or elderly white patients.
  • The presence or absence of atypia is helpful in determining the potential for malignancy, because PAM without atypia is usually benign, whereas PAM with atypia may convert into a conjunctival melanoma.
  • Slit lamp examination found a large dark area of elevated conjunctival pigmentation at the medial canthus that extended onto the superior bulbar conjunctiva and superior palpebral conjunctiva in the left eye.
  • No conjunctival pigmentation had been noted previously.
  • The lesion was surgically excised, and the conjunctiva was reconstructed with an amniotic membrane graft.
  • [MeSH-major] Conjunctival Diseases / pathology. Melanosis / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male

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  • (PMID = 16651212.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Steven P, Rupp J, Hüttmann G, Koop N, Lensing C, Laqua H, Gebert A: Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue. Invest Ophthalmol Vis Sci; 2008 Apr;49(4):1512-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue.
  • PURPOSE: Conjunctiva-associated lymphoid tissue (CALT) is assumed to be a key location for the generation of adaptive immune mechanisms of the ocular surface, but functional studies of CALT are still lacking.
  • METHODS: The conjunctiva of female BALB/c mice was repeatedly challenged with topical Chlamydia trachomatis serovar C or a solution of ovalbumin and cholera toxin B.
  • [MeSH-major] Conjunctiva / cytology. Imaging, Three-Dimensional. Lymphoid Tissue / cytology. Microscopy, Fluorescence

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  • (PMID = 18385070.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9006-59-1 / Ovalbumin; 9012-63-9 / Cholera Toxin
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76. Fukuda K, Nishida T: Ocular allergic inflammation: interaction between the cornea and conjunctiva. Cornea; 2010 Nov;29 Suppl 1:S62-7
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  • [Title] Ocular allergic inflammation: interaction between the cornea and conjunctiva.
  • Severe ocular allergic diseases such as vernal keratoconjunctivitis are characterized not only by conjunctival allergic inflammation, including infiltration of T helper 2 cells and eosinophils into the conjunctiva, but also by various corneal disorders such as persistent epithelial defects and shield ulcer.
  • Although the cornea and conjunctiva are thought to influence each other during ocular allergic inflammation, direct evidence for interaction between these tissues in vivo has been lacking.
  • We have recently shown that removal of the corneal epithelium augmented late-phase clinical signs and conjunctival eosinophilia, whereas conjunctival inflammation delayed corneal epithelial wound healing, in a rat model of ocular allergy.
  • Conjunctival allergic inflammation and corneal epithelial disorders thus interact with each other in vivo to generate a vicious cycle, interruption of which might provide the basis for novel approaches to the treatment of severe ocular allergy.
  • [MeSH-major] Conjunctiva / immunology. Conjunctivitis, Allergic / complications. Corneal Diseases / etiology. Epithelium, Corneal / immunology

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  • (PMID = 20935545.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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77. Suner S, Crawford G, McMurdy J, Jay G: Non-invasive determination of hemoglobin by digital photography of palpebral conjunctiva. J Emerg Med; 2007 Aug;33(2):105-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-invasive determination of hemoglobin by digital photography of palpebral conjunctiva.
  • It is possible to derive an objective method that correlates conjunctiva color with measured hemoglobin and, when applied prospectively, is able to predict hemoglobin concentration in ED patients.
  • [MeSH-major] Conjunctiva / blood supply. Hemoglobinometry / methods. Hemoglobins / analysis. Photography / methods

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  • [CommentIn] J Emerg Med. 2009 Apr;36(3):307; author reply 307-8 [19095397.001]
  • (PMID = 17692757.001).
  • [ISSN] 0736-4679
  • [Journal-full-title] The Journal of emergency medicine
  • [ISO-abbreviation] J Emerg Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins
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78. Demir U, Demir T, Akpolat N: The effect of octreotide against oxidative damage in photosensitized conjunctiva and cornea of rabbits. Doc Ophthalmol; 2005 Mar-May;110(2-3):193-201

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of octreotide against oxidative damage in photosensitized conjunctiva and cornea of rabbits.
  • The purpose of this study was to determine the protective effect of octreotide against oxidative damage in rabbit conjunctiva and cornea exposed to ultraviolet radiation.
  • Histopathologic analysis of each group indicated that UVA group and PUVA group showed increasing edema (p<0.01), inflammation (p<0.05), fibroblast proliferation (p<0.05), dysplasia (p<0.05), hyperchromasia (p<0.01) in the conjunctiva.
  • [MeSH-minor] Animals. Cell Proliferation. Conjunctiva / drug effects. Conjunctiva / pathology. Conjunctiva / radiation effects. Cornea / drug effects. Cornea / pathology. Cornea / radiation effects. Disease Models, Animal. Male. Rabbits. Treatment Outcome. Ultraviolet Rays / adverse effects

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  • (PMID = 16328927.001).
  • [ISSN] 0012-4486
  • [Journal-full-title] Documenta ophthalmologica. Advances in ophthalmology
  • [ISO-abbreviation] Doc Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; RWM8CCW8GP / Octreotide
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79. Georgescu D, Cole E, Epstein G, Fountain T, Migliori M, Nguyen Q, Mannor G, Weinberg D: Müller muscle-conjunctiva resection for blepharoptosis in patients with glaucoma filtering blebs. Ophthal Plast Reconstr Surg; 2007 Jul-Aug;23(4):285-7
Hazardous Substances Data Bank. PHENYLEPHRINE .

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  • [Title] Müller muscle-conjunctiva resection for blepharoptosis in patients with glaucoma filtering blebs.
  • PURPOSE: To study the safety and efficacy of Müller muscle-conjunctiva resection (MMCR) for blepharoptosis in patients with functional glaucoma-filtering blebs.
  • [MeSH-major] Blepharoptosis / surgery. Conjunctiva / surgery. Eyelids / surgery. Filtering Surgery. Glaucoma / surgery. Oculomotor Muscles / surgery

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  • (PMID = 17667098.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 1WS297W6MV / Phenylephrine
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80. Ebihara N, Nishikawa M, Murakami A: Disodium cromoglycate inhibits capsaicin-induced eosinophil infiltration of conjunctiva independent of mast cells. Jpn J Ophthalmol; 2006 May-Jun;50(3):205-10
Hazardous Substances Data Bank. CAPSAICIN .

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  • [Title] Disodium cromoglycate inhibits capsaicin-induced eosinophil infiltration of conjunctiva independent of mast cells.
  • PURPOSE: To investigate whether disodium cromoglycate (DSCG) inhibits capsaicin-induced eosinophil infiltration of the conjunctiva independent of mast cells.
  • METHODS: We administered 5 microl of capsaicin solution (10(-5) M) into the conjunctival sacs of mast cell-deficient W/W(v) mice (12 animals) and wild-type mice (12 animals).
  • The number of infiltrated eosinophils and the expression of vascular cell adhesion molecule-l (VCAM-1) in the conjunctiva were quantified by the staining method of Hansel and immunohistochemical analysis.
  • We also investigated whether treatment by depletion of neuropeptides or by DSCG administration could suppress the capsaicin-induced eosinophil infiltration of the conjunctiva.
  • RESULTS: In both W/W(v) and wild-type mice, eosinophil infiltration of conjunctival tissues was observed 3 h after capsaicin administration.
  • CONCLUSION: DSCG can directly inhibit neuropeptide-induced eosinophil infiltration of the conjunctiva independent of mast cells.
  • [MeSH-major] Anti-Asthmatic Agents / therapeutic use. Conjunctival Diseases / drug therapy. Cromolyn Sodium / therapeutic use. Eosinophilia / drug therapy. Mast Cells / pathology
  • [MeSH-minor] Animals. Capsaicin / toxicity. Conjunctiva / blood supply. Conjunctiva / drug effects. Conjunctiva / metabolism. Disease Models, Animal. Endothelium, Vascular / metabolism. Eyelids / blood supply. Eyelids / drug effects. Eyelids / metabolism. Immunohistochemistry. Male. Mice. Vascular Cell Adhesion Molecule-1 / biosynthesis

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  • (PMID = 16767373.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Asthmatic Agents; 0 / Vascular Cell Adhesion Molecule-1; Q2WXR1I0PK / Cromolyn Sodium; S07O44R1ZM / Capsaicin
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81. Pecorella I, Maurizio T, Antonio C, Giancarlo F: Progressive replacement of oral mucosa by conjunctiva in osteo-odonto-keratoprosthesis: preliminary observations. Cornea; 2006 Feb;25(2):193-5
MedlinePlus Health Information. consumer health - Corneal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Progressive replacement of oral mucosa by conjunctiva in osteo-odonto-keratoprosthesis: preliminary observations.
  • RESULTS: Six of the 7 clinically modified specimens corresponded microscopically to conjunctiva.
  • CONCLUSIONS: The production of local regulatory factors is a possible explanation for the survival of oral mucosa over the osteodental acrylic lamina, whereas their absence in distant areas may have induced the oral mucosa to transdifferentiate into a conjunctival-type lining.
  • Alternatively, conjunctival regrowth from forniceal stem cells should be taken into consideration.
  • [MeSH-major] Alveolar Process / transplantation. Bioprosthesis. Conjunctiva / cytology. Cornea / surgery. Corneal Diseases / surgery. Mouth Mucosa / transplantation. Prostheses and Implants

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  • (PMID = 16371780.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylates
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82. Wang M, Yoshida A, Kawashima H, Ishizaki M, Takahashi H, Hori J: Immunogenicity and antigenicity of allogeneic amniotic epithelial transplants grafted to the cornea, conjunctiva, and anterior chamber. Invest Ophthalmol Vis Sci; 2006 Apr;47(4):1522-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunogenicity and antigenicity of allogeneic amniotic epithelial transplants grafted to the cornea, conjunctiva, and anterior chamber.
  • METHODS: Intact AE from enhanced green fluorescence protein (EGFP) transgenic mice (C57BL/6 background) and wild-type C57BL/6 mice were transplanted onto cornea or conjunctiva, or inserted into the anterior chamber (AC) of normal BALB/c mice, C57BL/6 mice, or BALB/c mice presensitized to donor antigens.
  • RESULTS: In normal recipients, GFP+ cells were absent in EGFP donor-derived AE grafts by day 21 on cornea and by day 7 on conjunctiva.
  • DH was induced at 2 weeks, but failed to be induced at 4 weeks after grafting on cornea or at 8 weeks after grafting on conjunctiva and in the AC of normal recipients.
  • [MeSH-major] Amnion / immunology. Amnion / transplantation. Anterior Chamber / surgery. Conjunctiva / surgery. Cornea / surgery

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  • (PMID = 16565388.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoantigens; 0 / Luminescent Agents; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins
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83. Cauvain A, Delmer A, Godeau MJ, Molina T, Durdux C, Marinho E, Crickx B, Descamps V: [MALT (Mucosal Associated Lymphoid Tissue) lymphoma of the palpebral conjunctiva]. Ann Dermatol Venereol; 2006 Feb;133(2):168-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [MALT (Mucosal Associated Lymphoid Tissue) lymphoma of the palpebral conjunctiva].
  • [Transliterated title] Lymphome B de la zone marginale de type MALT de la conjonctive palpébrale.
  • BACKGROUND: MALT (Mucosal Associated Lymphoid Tissue) lymphomas of the conjunctiva belong to the extranodal marginal zone B-cell lymphomas.
  • CASE-REPORT: A pink papular tumor developed on the lower eyelid of a 59-year-old woman.
  • Histological examination yielded a diagnosis of conjunctival MALT lymphoma.
  • Treatment of conjunctival MALT lymphoma is standardized.
  • [MeSH-major] Conjunctival Neoplasms. Eyelid Neoplasms. Lymphoma, B-Cell, Marginal Zone
  • [MeSH-minor] Biopsy. Conjunctiva / pathology. Eyelids / pathology. Female. Follow-Up Studies. Humans. Middle Aged. Radiotherapy Dosage. Remission Induction. Time Factors

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  • (PMID = 16508604.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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84. Nagasaki T, Zhao J: Uniform distribution of epithelial stem cells in the bulbar conjunctiva. Invest Ophthalmol Vis Sci; 2005 Jan;46(1):126-32
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  • [Title] Uniform distribution of epithelial stem cells in the bulbar conjunctiva.
  • PURPOSE: To determine the distribution of epithelial stem cells in the bulbar conjunctiva by measuring homeostatic movements and mitosis of epithelial cells in this region.
  • METHODS: The ubiquitous GFP mouse was used to monitor movement of conjunctival epithelial cells.
  • Cell movement was determined by histology, analyzing the shape and distribution of GFP cell clusters in flat wholemount specimens, and by in vivo time-lapse microscopy, tracking the movement of GFP-positive cells in the bulbar conjunctiva near the limbus.
  • RESULTS: Similar to the corneal epithelium, only some of the conjunctival epithelial cells expressed a high level of GFP.
  • No stripe pattern of GFP was observed in any part of the conjunctiva, suggesting that directed cell movement was rare or nonexistent.
  • CONCLUSIONS: Epithelial cells of the bulbar conjunctiva near the limbus are mitotically active and yet they are generally immobile in a lateral direction, indicating that these cells are self-sufficient.
  • [MeSH-major] Conjunctiva / cytology. Epithelial Cells / cytology. Stem Cells / cytology

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  • (PMID = 15623764.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY00431
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins; 9007-49-2 / DNA; G34N38R2N1 / Bromodeoxyuridine
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85. Zhu W, Hong J, Zheng T, Le Q, Xu J, Sun X: Age-related changes of human conjunctiva on in vivo confocal microscopy. Br J Ophthalmol; 2010 Nov;94(11):1448-53
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  • [Title] Age-related changes of human conjunctiva on in vivo confocal microscopy.
  • AIMS: To analyse age-related changes of human conjunctiva by in vivo laser scanning confocal microscopy (LSCM).
  • The morphology and densities of conjunctival epithelial cells, goblet cells (GCs), dendritic cells (DCs) and the positive rate of conjunctival microcysts were analysed.
  • RESULTS: The morphology and the densities of both conjunctival epithelial cells and GCs showed no significant age-related differences.
  • The positive rates of conjunctival microcysts were 30% (6/20), 50% (10/20), 60% (12/20) and 75% (15/20) in each group, showing a substantial increase with age (p = 0.035).
  • Even though no significant changes in GCs densities could be seen in the different age groups, the increasing rates of conjunctival microcysts indicated that the cellular function of GCs declined while ageing.
  • [MeSH-major] Aging / physiology. Conjunctiva / cytology

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  • (PMID = 20494916.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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86. Kumagai N, Fukuda K, Fujitsu Y, Yamamoto K, Nishida T: Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis. Prog Retin Eye Res; 2006 Mar;25(2):165-87
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  • [Title] Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis.
  • Vernal keratoconjunctivitis (VKC) is a severe type of allergic conjunctival disease characterized by the presence both of various corneal epithelial and stromal lesions as well as of conjunctival proliferative changes such as giant papillae of the upper tarsal conjunctiva and limbal lesions.
  • The outer eye possesses specific allergological characteristics, one of which is communication between the cornea and conjunctiva through a thin layer of tear fluid.
  • Fibroblasts of the cornea and the conjunctiva are activated by proinflammatory and T helper 2 (Th2) cell-derived cytokines.
  • Exaggerated proliferation of and deposition of extracellular matrix by conjunctival fibroblasts likely exacerbate conjunctival inflammation.
  • Restoration of an intact corneal epithelium and inhibition of the activities of corneal and conjunctival fibroblasts may provide a basis for the development of new treatments for severe ocular allergic diseases such as VKC.
  • [MeSH-major] Conjunctiva / pathology. Conjunctivitis, Allergic / pathology. Corneal Stroma / pathology. Epithelium, Corneal / pathology

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  • (PMID = 16427347.001).
  • [ISSN] 1350-9462
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 200
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87. Dalfré JT, Rodrigues JP, Donato BG, Giancoli Neto A, de Carvalho JL, de Andrade Oliveira DI, Pereira MA, Fiorini JE: [Fungic microbiota of normal conjunctiva, sugar-cane and anemophilous fungi of the region of Monte Belo - Minas Gerais]. Arq Bras Oftalmol; 2007 May-Jun;70(3):445-9
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  • [Title] [Fungic microbiota of normal conjunctiva, sugar-cane and anemophilous fungi of the region of Monte Belo - Minas Gerais].
  • [Transliterated title] Microbiota fúngica da conjuntiva, da cana-de-açúcar e de anemófilos da região canavieira de Monte Belo - Minas Gerais.
  • AIM: To evaluate the incidence of fungi in the ocular conjunctiva of sugar-cane cutting workers as well in a sugar-cane plantation environment.
  • METHODS: Swabs were made from the ocular conjunctiva of one hundred workers of both sexes and material was collected from leaves, stalk, and the environmental air from the sugar-cane plantation.
  • CONCLUSION: The environmental conditions, the socioeconomic status and the general and personal poor hygienic conditions, together with lack of information about prophylactic standards, surely led to the high incidence of ocular conjunctiva fungus isolation (67%).
  • The isolated filamentous fungi were much more numerous than yeast, there being some correlation between these and the conjunctiva isolates.
  • [MeSH-major] Conjunctiva / microbiology. Crops, Agricultural / microbiology. Fungi / isolation & purification. Occupational Exposure. Saccharum / microbiology

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  • (PMID = 17768551.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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88. Suzuki T, Kawamura Y, Uno T, Ohashi Y, Ezaki T: Prevalence of Staphylococcus epidermidis strains with biofilm-forming ability in isolates from conjunctiva and facial skin. Am J Ophthalmol; 2005 Nov;140(5):844-850

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence of Staphylococcus epidermidis strains with biofilm-forming ability in isolates from conjunctiva and facial skin.
  • PURPOSE: To compare the prevalence of biofilm-forming strains of Staphylococcus epidermidis in the conjunctival and facial skin microflora.
  • METHODS: The prevalence of biofilm-forming ability of 10 S epidermidis strains obtained from the conjunctival sac of healthy volunteers was compared with 40 strains obtained from the facial skin of healthy volunteers.
  • Additionally, the prevalence of 36 S epidermidis strains obtained from the conjunctival sac of precataract patients to form biofilm was investigated.
  • RESULTS: The icaA gene was detected in 60% of the isolates from the conjunctival sac of volunteers and 15% of those from the facial skin.
  • Fifty percent of the isolates from the conjunctiva of volunteers and 5% from the facial skin were CRA positive.
  • Biofilm production was significantly greater in isolates from the conjunctiva of volunteers.
  • Of the nine pairs of isolates found in the same volunteers, six conjunctival sac isolates were positive for the icaA gene with biofilm-forming ability except one strain, whereas only one of the facial skin isolates was positive for the icaA gene and none exhibited biofilm-forming phenotype.
  • Sixty-nine percent and 44% of the isolates from the conjunctival sac of precataract patients were positive for icaA gene and CRA test, respectively.
  • CONCLUSIONS: The prevalence of biofilm-forming S epidermidis isolates is higher in the conjunctival sac than the facial skin.
  • [MeSH-major] Biofilms / growth & development. Conjunctiva / microbiology. Skin / microbiology. Staphylococcus epidermidis / physiology

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  • (PMID = 16310462.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA, Bacterial; 0 / Polysaccharides, Bacterial
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89. Detorakis ET, Zaravinos A, Spandidos DA: Growth factor expression in ophthalmic pterygia and normal conjunctiva. Int J Mol Med; 2010 Apr;25(4):513-6
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  • [Title] Growth factor expression in ophthalmic pterygia and normal conjunctiva.
  • The expression of growth factors in ophthalmic pterygium and phenotypically normal conjunctiva was examined and correlated with the clinical findings.
  • Fifteen specimens of ophthalmic pterygia and 8 specimens of phenotypically normal conjunctiva were examined.
  • Differences in the expression of these factors between pterygium and conjunctival specimens were examined, as well as correlations between RNA levels and clinical parameters. mRNA levels for VEGFA and FGF2 were significantly higher in pterygium, compared with conjunctival specimens, whereas the respective differences for other factors examined were statistically not significant.
  • [MeSH-major] Conjunctiva / metabolism. Conjunctiva / pathology. Gene Expression Regulation. Intercellular Signaling Peptides and Proteins / genetics. Intercellular Signaling Peptides and Proteins / metabolism. Pterygium / genetics

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  • (PMID = 20198298.001).
  • [ISSN] 1791-244X
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2; 62229-50-9 / Epidermal Growth Factor; 67763-96-6 / Insulin-Like Growth Factor I
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90. Nadri S, Soleimani M, Mobarra Z, Amini S: Expression of dopamine-associated genes on conjunctiva stromal-derived human mesenchymal stem cells. Biochem Biophys Res Commun; 2008 Dec 12;377(2):423-428
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  • [Title] Expression of dopamine-associated genes on conjunctiva stromal-derived human mesenchymal stem cells.
  • In the present study, human mesenchymal stem cells (MSCs) from eye conjunctiva stromal cells were differentiated into dopaminergic neurons.
  • In this work, after conjunctiva biopsy, mesenchymal stem cells were obtained via adherence to the plastic culture dishes.
  • [MeSH-major] Conjunctiva / cytology. Dopamine / biosynthesis. Gene Expression. Mesenchymal Stromal Cells / cytology. Neurons / cytology

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  • (PMID = 18851950.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] VTD58H1Z2X / Dopamine
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91. Fukushima A, Jian Z, Ishida W, Fukata K, Ozaki A, Ueno H: Interleukin-4-mediated infiltration of eosinophils into the conjunctiva and its suppression by interferon-gamma. Curr Eye Res; 2005 Feb;30(2):115-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interleukin-4-mediated infiltration of eosinophils into the conjunctiva and its suppression by interferon-gamma.
  • It has been suggested that IL-4 is responsible for the infiltration of eosinophils into the conjunctiva during the development of allergic conjunctivitis.
  • We investigated whether subconjunctival injection of IL-4 can induce eosinophils to infiltrate into the conjunctiva.
  • RESULTS: The subconjunctival injection of IL-4 induced eosinophil infiltration into the conjunctiva in a dose-dependent manner.
  • RT-PCR analysis demonstrated that IL-4 injection did not upregulate chemokine RNA expression in the conjunctiva.
  • Coinjection of IFN-gamma suppressed the infiltration of eosinophils into the conjunctiva induced by IL-4 injection.
  • CONCLUSIONS: The subconjunctival injection of IL-4 specifically induces eosinophils to infiltrate into the conjunctiva.
  • In addition, IFN-gamma in the conjunctiva can counteract this effect of IL-4.
  • [MeSH-major] Cell Movement / drug effects. Conjunctiva / cytology. Eosinophils / physiology. Interferon-gamma / pharmacology. Interleukin-4 / pharmacology

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  • (PMID = 15814469.001).
  • [ISSN] 0271-3683
  • [Journal-full-title] Current eye research
  • [ISO-abbreviation] Curr. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ccl11 protein, rat; 0 / Chemokine CCL11; 0 / Chemokines; 0 / Chemokines, CC; 0 / Cytokines; 0 / Drug Combinations; 0 / Recombinant Proteins; 207137-56-2 / Interleukin-4; 82115-62-6 / Interferon-gamma
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92. Aspiotis M, Gorezis S, Asproudis I, Tsanou E, Papadiotis E, Kamina S, Agnantis NJ, Bai M: Primary mantle cell lymphoma of the conjunctiva: a case report. Virchows Arch; 2006 Oct;449(4):472-5
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  • [Title] Primary mantle cell lymphoma of the conjunctiva: a case report.
  • Primary non-Hodgkin's lymphomas of the conjunctiva are uncommon.
  • In this study, we report an extremely rare case of conjunctival mantle cell lymphoma in a 78-year-old man, presenting as a unilateral epibulbar mass.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / pathology. Lymphoma, Mantle-Cell / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Humans. Immunohistochemistry. Male

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  • [Cites] Am J Hematol. 2003 Jun;73(2):87-96 [12749009.001]
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  • (PMID = 16969632.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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93. Khalfaoui T, Beltaief O, Meddeb Amel O: [Expression of Bax and Bcl-2 apoptotic factors in the conjunctiva of diabetic patients: a preliminary study]. J Fr Ophtalmol; 2007 Oct;30(8):799-806
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  • [Title] [Expression of Bax and Bcl-2 apoptotic factors in the conjunctiva of diabetic patients: a preliminary study].
  • [Transliterated title] Expression des facteurs apoptotiques Bax et Bcl-2 dans la conjonctive des patients diabétiques: étude préliminaire.
  • The aim of our study was to analyze the expression of apoptotic factors Bax and Bcl-2 in the bulbar conjunctiva of diabetic patients without retinopathy and to compare it to the expression of these factors in nondiabetic patients.
  • MATERIAL AND METHODS: Twenty-five conjunctival biopsies were obtained from diabetic patients without retinopathy.
  • Normal human conjunctiva was taken from 15 patients undergoing senile cataract surgery.
  • RESULTS: In the human diabetic conjunctiva, The Bax protein was highly expressed in all specimens (100%).
  • In normal conjunctiva, Bax showed a significant level, whereas Bcl-2 showed no trace of positivity.
  • Our results suggest that diabetic human conjunctiva, with its inflammatory and cicatricial phenomena, is a privileged target for apoptotic cell death.
  • [MeSH-major] Conjunctiva / physiopathology. Diabetes Mellitus / physiopathology. Proto-Oncogene Proteins c-bcl-2 / metabolism. bcl-2-Associated X Protein / metabolism

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  • (PMID = 17978676.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein
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94. Becht Ch: [Common immune mediated disorders of the conjunctiva in a general practice]. Praxis (Bern 1994); 2009 Apr 15;98(8):429-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Common immune mediated disorders of the conjunctiva in a general practice].
  • [Transliterated title] Allergische Augenerkrankungen in der Praxis.
  • The symptoms and signs help to diagnose an immune-mediated disorder of the conjunctiva in the general practice.
  • [MeSH-major] Conjunctivitis, Allergic / diagnosis
  • [MeSH-minor] Asthma / diagnosis. Asthma / etiology. Dermatitis, Atopic / diagnosis. Dermatitis, Atopic / etiology. Diagnosis, Differential. Humans. Patient Care Team. Referral and Consultation

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  • (PMID = 19373760.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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95. Kim JH, Bae HW, Lee KK, Kim TI, Kim EK: Seborrheic keratosis of the conjunctiva: a case report. Korean J Ophthalmol; 2009 Dec;23(4):306-8
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  • [Title] Seborrheic keratosis of the conjunctiva: a case report.
  • Seborrheic keratosis is a benign epithelial neoplasia that occurs mainly in the skin of the eyelids and face.
  • We describe a case of seborrheic keratosis of the conjunctiva confirmed by histopathology.
  • A 72-year-old man presented with a recurrent conjunctival mass involving the nasal side of his right eye.
  • Clinically, a diagnosis of conjunctival papilloma was made, and a mass excision was performed.
  • The histopathological analysis evidenced a conjunctival-covering epithelium with papillomatous changes and irregular acanthosis, at the expense of a proliferation of basaloid cells.
  • With the above findings, a diagnosis of conjunctival seborrheic keratosis was established.
  • The occurrence of seborrheic keratosis on the conjunctiva is rare.
  • Seborrheic keratosis should be considered in the differential diagnosis of conjunctival lesions.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Keratosis, Seborrheic / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Microscopy, Acoustic. Ophthalmologic Surgical Procedures / methods

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  • (PMID = 20046694.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2789958
  • [Keywords] NOTNLM ; Conjunctival mass / Papilloma / Seborrheic keratosis
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96. Yu DY, Morgan WH, Sun X, Su EN, Cringle SJ, Yu PK, House P, Guo W, Yu X: The critical role of the conjunctiva in glaucoma filtration surgery. Prog Retin Eye Res; 2009 Sep;28(5):303-28
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  • [Title] The critical role of the conjunctiva in glaucoma filtration surgery.
  • This review considers the critical role of the conjunctiva in determining the success or failure of glaucoma filtration surgery.
  • We propose that factors such as the degree of tissue damage during surgery, the surrounding tissue reaction to any surgical implant, and the degree of disruption of normal aqueous properties, are all factors which influence the successful formation of long term drainage channels from the conjunctiva, and that these channels are the key to successful filtration surgery.
  • We describe for the first time a novel type of drainage surgery which attempts to minimise surgical trauma to the overlying conjunctiva.
  • The rationale is that a healthy conjunctiva allows drainage channels to form and less opportunity for inflammation and scar tissue formation which are a frequent cause of failure in glaucoma filtration surgery.
  • A new philosophy in glaucoma drainage surgery is proposed in which minimisation of surgical trauma to the conjunctiva and the encouragement of the development of conjunctival drainage pathways, particularly lymphatic pathways, are central pillars to a successful outcome in glaucoma filtration surgery.
  • [MeSH-major] Conjunctiva / surgery. Filtering Surgery. Glaucoma / surgery

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  • (PMID = 19573620.001).
  • [ISSN] 1873-1635
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 187
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97. Terai N, Schlötzer-Schrehardt U, Lampel J, Böhm AG, Rummelt C, Schmidt E, Pillunat LE: Effect of latanoprost and timolol on the histopathology of the human conjunctiva. Br J Ophthalmol; 2009 Feb;93(2):219-24
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  • [Title] Effect of latanoprost and timolol on the histopathology of the human conjunctiva.
  • AIM: To investigate the effect of timolol and latanoprost on the extracellular matrix organisation, inflammatory infiltration, and expression of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in the human conjunctiva.
  • METHODS: Conjunctival biopsies were obtained from the inferior fornix during routine cataract surgery from 20 patients with primary open-angle glaucoma, who had received a monotherapy either with timolol or latanoprost, and from 10 non-glaucomatous patients.
  • RESULTS: The number of collagen fibres was significantly decreased in latanoprost-treated conjunctival specimens compared with timolol-treated eyes (p<0.01) but showed no difference to controls.
  • CONCLUSIONS: Latanoprost-treated conjunctival specimens showed a decreased stromal collagen density and a less pronounced inflammatory infiltration.
  • The upregulation of MMP-1 and MMP-3 in latanoprost-treated eyes might explain the reduced extracellular matrix accumulation in the conjunctival stroma.
  • [MeSH-major] Antihypertensive Agents / pharmacology. Conjunctiva / drug effects. Prostaglandins F, Synthetic / pharmacology. Timolol / pharmacology

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  • (PMID = 18971237.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antihypertensive Agents; 0 / CD68 antigen, human; 0 / Prostaglandins F, Synthetic; 0 / Tissue Inhibitor of Metalloproteinases; 6Z5B6HVF6O / latanoprost; 817W3C6175 / Timolol; 9007-34-5 / Collagen; EC 3.4.24.- / Matrix Metalloproteinases
  • [Other-IDs] NLM/ PMC2628534
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98. Aslan O, Teberik K, Yucel M, Gur N, Karakoc AE: Effect of topical netilmicin on the reduction of bacterial flora on the human conjunctiva. Eur J Ophthalmol; 2008 Jul-Aug;18(4):512-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of topical netilmicin on the reduction of bacterial flora on the human conjunctiva.
  • PURPOSE: To investigate the effects of topical netilmicin on human conjunctival bacterial flora.
  • After 1 day of netilmicin application cultures of the inferior palpebral conjunctiva were performed in both eyes.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Antibiotic Prophylaxis. Bacteria / drug effects. Conjunctiva / microbiology. Netilmicin / therapeutic use

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  • (PMID = 18609467.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Ophthalmic Solutions; 4O5J85GJJB / Netilmicin
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99. Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F: In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci; 2005 Dec;46(12):4594-9
Hazardous Substances Data Bank. HYDROGEN PEROXIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells.
  • PURPOSE: In a previous study, it was demonstrated that in vitro in a human conjunctiva-derived cell line, latanoprost in its commercial presentation appeared to be less toxic than the benzalkonium chloride (BAC) it contains as a preservative.
  • METHODS: Human conjunctiva-derived epithelial cells from the Chang cell line were exposed to three prostaglandins in their commercial presentation (latanoprost, travoprost, and bimatoprost) and to three concentrations of BAC (0.02%, 0.015%, and 0.005%), corresponding to the concentrations contained in the three prostaglandin eyedrops.
  • Each solution was diluted to 1/10 and was applied for 30 minutes Cellular membrane integrity, cytosolic H2O2, cytosolic O2*- and apoptosis were evaluated using neutral red, H2DCF-DA, hydroethidine, and Yopro-1 probes, respectively.
  • CONCLUSIONS: Latanoprost and travoprost were responsible for significant protective effects against BAC toxicity on conjunctiva-derived epithelial cells in vitro, probably related to their antioxidative properties.
  • [MeSH-major] Antihypertensive Agents / pharmacology. Antioxidants / pharmacology. Cloprostenol / analogs & derivatives. Conjunctiva / drug effects. Epithelial Cells / drug effects. Lipids / pharmacology. Prostaglandins F, Synthetic / pharmacology

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  • (PMID = 16303954.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amides; 0 / Antihypertensive Agents; 0 / Antioxidants; 0 / Benzalkonium Compounds; 0 / Lipids; 0 / Preservatives, Pharmaceutical; 0 / Prostaglandins F, Synthetic; 0 / Reactive Oxygen Species; 11062-77-4 / Superoxides; 4208238832 / Cloprostenol; 6Z5B6HVF6O / latanoprost; BBX060AN9V / Hydrogen Peroxide; QXS94885MZ / Bimatoprost; WJ68R08KX9 / Travoprost
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100. Chen W, Zhao K, Li X, Yoshitomi T: Keratoconjunctivitis sicca modifies epithelial stem cell proliferation kinetics in conjunctiva. Cornea; 2007 Oct;26(9):1101-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Keratoconjunctivitis sicca modifies epithelial stem cell proliferation kinetics in conjunctiva.
  • Changes in ocular surface epithelial morphology and significantly reduced density of conjunctival goblet cells were found in dry eye groups.
  • The number of conjunctival BrdU label-retaining cells in the rats with dry eye was significantly decreased compared with control rats (P < 0.01 for both groups).
  • Furthermore, BrdU labeling in the before dry eye induction group showed more label-retaining basal cells in the conjunctiva than labeling in the dry eye state group (P < 0.01).
  • CONCLUSIONS: Experimentally induced KCS in rats causes significant modification of epithelial stem cell proliferation kinetics in conjunctiva.
  • The modification of epithelial stem cell proliferation kinetics in conjunctiva may play a crucial role in the development of KCS and may be a therapeutic target for this condition.
  • [MeSH-major] Cell Proliferation. Conjunctiva / pathology. Epithelial Cells / pathology. Keratoconjunctivitis Sicca / pathology. Stem Cells / pathology

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  • (PMID = 17893543.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluoresceins; 3301-79-9 / 6-carboxyfluorescein; 451IFR0GXB / Scopolamine Hydrobromide; G34N38R2N1 / Bromodeoxyuridine
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