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1. Hu Y, Zhang T, Wu J, Li Y, Lu X, Qian F, Yin Z, Ma Z: Autologous transplantation of RPE with partial-thickness choroid after mechanical debridement of Bruch membrane in the rabbit. Invest Ophthalmol Vis Sci; 2008 Jul;49(7):3185-92
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  • [Title] Autologous transplantation of RPE with partial-thickness choroid after mechanical debridement of Bruch membrane in the rabbit.
  • The graft consists of a sheet of a partial-thickness choroid with RPE attached.
  • After mechanical debridement of Bruch membrane, partial-thickness RPE-choroid sheets were transplanted onto the subretinal space in 25 rabbits.
  • In addition, two partial-thickness RPE-choroid sheets were analyzed by transmission electron microscopy (TEM).
  • RESULTS: TEM revealed that the partial-thickness RPE-choroid graft consisted of retinal pigment epithelial cells, Bruch membrane, choriocapillaris, and ruptured middle vessels.
  • CONCLUSIONS: A partial-thickness RPE-choroid graft showed improved integration with the host choroid and photoreceptors.
  • [MeSH-major] Bruch Membrane / surgery. Choroid / transplantation. Debridement. Pigment Epithelium of Eye / transplantation

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  • (PMID = 18390637.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9009-81-8 / Rhodopsin
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2. Pandiri AK, Cortes AL, Lee LF, Gimeno IM: Marek's disease virus infection in the eye: chronological study of the lesions, virus replication, and vaccine-induced protection. Avian Dis; 2008 Dec;52(4):572-80
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  • The early lesions involved iris, ciliary body, and choroid layer, and were characterized by endothelial cell hypertrophy, vasculitis, and infiltration of lymphocytes (mainly CD8+), plasma cells, macrophages, and heterophils.
  • Expression of early MDV-antigen pp38 in the cells infiltrating choroid layer was detected as early as 11 dpi.
  • [MeSH-minor] Animals. Choroid / pathology. Female. Immunohistochemistry. Male. Retina / pathology. Time Factors

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  • (PMID = 19166047.001).
  • [ISSN] 0005-2086
  • [Journal-full-title] Avian diseases
  • [ISO-abbreviation] Avian Dis.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Marek Disease Vaccines
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3. Jovanova-Nesic K, Jovicic S, Sovilj M, Spector NH: Magnetic brain stimulation upregulates adhesion and prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target. Int J Neurosci; 2009;119(9):1399-418
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  • [Title] Magnetic brain stimulation upregulates adhesion and prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target.
  • [MeSH-major] Cell Adhesion / physiology. Choroid Plexus / metabolism. Deep Brain Stimulation. Encephalomyelitis, Autoimmune, Experimental / prevention & control. Intercellular Adhesion Molecule-1 / biosynthesis. Matrix Metalloproteinase 2 / biosynthesis. Vascular Cell Adhesion Molecule-1 / biosynthesis

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  • (PMID = 19922364.001).
  • [ISSN] 1563-5279
  • [Journal-full-title] The International journal of neuroscience
  • [ISO-abbreviation] Int. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Vascular Cell Adhesion Molecule-1; 126547-89-5 / Intercellular Adhesion Molecule-1; EC 3.4.24.24 / Matrix Metalloproteinase 2
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4. Wimmers S, Coeppicus L, Rosenthal R, Strauss O: Expression profile of voltage-dependent Ca2+ channel subunits in the human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol; 2008 May;246(5):685-92
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  • BACKGROUND: The secretion of a variety of factors by the retinal pigment epithelium (RPE) is essential for the structural integrity of the neuronal retina and choroid, but also plays a pivotal role in the etiology of diseases such as choroidal neovascularisation.

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  • (PMID = 18270725.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Protein Subunits; 0 / RNA, Messenger; SY7Q814VUP / Calcium
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5. Hirata Y, Nishiwaki H: The choroidal circulation assessed by laser-targeted angiography. Prog Retin Eye Res; 2006 Mar;25(2):129-47
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  • The choroid plays an important role in supplying nutrients to and removing waste products from the outer region of the retina.
  • Carboxyfluorescein (CF), encapsulated in heat-sensitive liposomes, is released locally in the choroid through the application of a heat beam provided by an infrared laser.
  • [MeSH-major] Choroid / blood supply. Fluorescein Angiography / methods. Lasers. Microcirculation / physiology

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  • (PMID = 16226483.001).
  • [ISSN] 1350-9462
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 81
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6. Daghighi MH, Rezaei V, Zarrintan S, Pourfathi H: Intracranial physiological calcifications in adults on computed tomography in Tabriz, Iran. Folia Morphol (Warsz); 2007 May;66(2):115-9
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  • The structures evaluated consisted of (A) the pineal gland, (B) the choroid plexus, (C) the habenula, (D) the basal ganglia, (E) the tentorium cerebelli, sagittal sinus and falx cerebri, (F) vessels and (G) lens and other structures which could be calcified.
  • Of the 1569 subjects, 71.0% had pineal calcification, 66.2% had choroid plexus calcification, 20.1% had habenular calcification, 7.3% had tentorium cerebelli, sagittal sinus or falx cerebri calcifications, 6.6% had vascular calcification, 0.8% had basal ganglia calcification and 0.9% had lens and other non-defined calcifications.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Aging / physiology. Basal Ganglia / anatomy & histology. Basal Ganglia / physiology. Basal Ganglia / radiography. Calcification, Physiologic / physiology. Choroid Plexus / anatomy & histology. Choroid Plexus / physiology. Choroid Plexus / radiography. Craniocerebral Trauma / pathology. Craniocerebral Trauma / physiopathology. Female. Habenula / anatomy & histology. Habenula / physiology. Habenula / radiography. Humans. Iran. Lens, Crystalline / anatomy & histology. Lens, Crystalline / physiology. Lens, Crystalline / radiography. Male. Middle Aged. Pineal Gland / anatomy & histology. Pineal Gland / physiology. Pineal Gland / radiography. Sex Characteristics

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  • (PMID = 17594669.001).
  • [ISSN] 0015-5659
  • [Journal-full-title] Folia morphologica
  • [ISO-abbreviation] Folia Morphol. (Warsz)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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7. Chen XG, He SZ: [Gene expression patterns of choroidal neovascularization induced by krypton laser photocoagulation]. Zhonghua Yan Ke Za Zhi; 2005 Apr;41(4):317-20
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  • METHODS: Total RNA was isolated from normal choroid and choroid tissues with neovascularization induced by krypton laser photocoagulation in Brown Norway rat.

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  • (PMID = 15924692.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 5I8I620HVX / Krypton
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8. Bottalico JN, Chen X, Tartaglia M, Rosario B, Yarabothu D, Nelson L: Second-trimester genetic sonogram for detection of fetal chromosomal abnormalities in a community-based antenatal testing unit. Ultrasound Obstet Gynecol; 2009 Feb;33(2):161-8
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  • The sonographic detection of a major congenital anomaly or a sonographic marker (increased nuchal skinfold, short humerus, short femur, echogenic bowel, pyelectasis, echogenic intracardiac focus, absence or hypoplasia of fifth mid phalanx or choroid plexus cyst) was recorded.
  • Major structural defects and sonographic markers, excluding hypoplastic fifth digit and choroid plexus cyst, occurred significantly more frequently in Down syndrome cases compared with normal ones.

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  • (PMID = 19173242.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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9. Meyer G: Building a human cortex: the evolutionary differentiation of Cajal-Retzius cells and the cortical hem. J Anat; 2010 Oct;217(4):334-43
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  • A significant source of CR cells is the cortical hem, a putative signalling centre at the interface of the prospective hippocampus and the choroid plexus.
  • In this review, we analyze the multiple sources of reelin/p73 positive CR cells at the interface of various telencephalic centres and the choroid plexus of the lateral ventricles.
  • The close association between cortical hem and choroid plexus suggests a concerted role in the evolutionary increase of CR cells, amplification of the reelin signal in the marginal zone, and cortical expansion.
  • [MeSH-major] Cell Adhesion Molecules, Neuronal / metabolism. Cell Differentiation / physiology. Cerebral Cortex / cytology. Cerebral Cortex / physiology. Choroid Plexus / metabolism. DNA-Binding Proteins / metabolism. Extracellular Matrix Proteins / metabolism. Hippocampus / metabolism. Nerve Tissue Proteins / metabolism. Nuclear Proteins / metabolism. Serine Endopeptidases / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] © 2010 The Author. Journal of Anatomy © 2010 Anatomical Society of Great Britain and Ireland.
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  • (PMID = 20626498.001).
  • [ISSN] 1469-7580
  • [Journal-full-title] Journal of anatomy
  • [ISO-abbreviation] J. Anat.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules, Neuronal; 0 / DNA-Binding Proteins; 0 / Extracellular Matrix Proteins; 0 / Nerve Tissue Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / reelin protein
  • [Other-IDs] NLM/ PMC2992412
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10. Hahn P, Song Y, Ying GS, He X, Beard J, Dunaief JL: Age-dependent and gender-specific changes in mouse tissue iron by strain. Exp Gerontol; 2009 Sep;44(9):594-600
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  • Brain, liver, heart, retina, and retinal pigment epithelium (RPE)/choroid were dissected from male and female mice of young adult (2-6 month old) and aged (16-19 month old) C57BL/6, DBA/2J, and BALB/c mice.
  • Brain, liver, and heart iron increased by 30-70% in aged vs. young adult groups of all strains, while retina and RPE/choroid iron had variable age-related changes.
  • Males had as much as 2- to 3-fold more brain, RPE/choroid, and retinal iron, while females had as much as 2- to 3-fold more liver iron.

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  • (PMID = 19563877.001).
  • [ISSN] 1873-6815
  • [Journal-full-title] Experimental gerontology
  • [ISO-abbreviation] Exp. Gerontol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01 EY015240
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Reactive Oxygen Species; E1UOL152H7 / Iron
  • [Other-IDs] NLM/ NIHMS716733; NLM/ PMC4552188
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11. Dickens DS, Dothage JA, Heideman RL, Ballard ET, Jubinsky PT: Successful treatment of an unresectable choroid plexus carcinoma in a patient with Li-Fraumeni syndrome. J Pediatr Hematol Oncol; 2005 Jan;27(1):46-9
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  • [Title] Successful treatment of an unresectable choroid plexus carcinoma in a patient with Li-Fraumeni syndrome.
  • Choroid plexus carcinoma (CPC) is an uncommon central nervous system tumor requiring complete surgical excision for favorable outcome.
  • Following a partial resection of the tumor the patient received chemotherapy consisting of cyclophosphamide, etoposide, and carboplatin.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma / drug therapy. Choroid Plexus Neoplasms / drug therapy. Li-Fraumeni Syndrome / drug therapy. Neoplasm Metastasis / drug therapy

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  • (PMID = 15654279.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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12. Okamoto H, Mineta T, Ueda S, Nakahara Y, Shiraishi T, Tamiya T, Tabuchi K: Detection of JC virus DNA sequences in brain tumors in pediatric patients. J Neurosurg; 2005 Apr;102(3 Suppl):294-8
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  • METHODS: Genomic DNA sequences were isolated from 62 brain tumors (32 medulloblastomas, 18 ependymomas, five choroid plexus papillomas, and seven pilocytic astrocytomas) and analyzed for the presence of JC virus DNA by Southern blot hybridization and direct sequencing.
  • The JC virus DNA sequence was detected in five ependymomas and one choroid plexus papilloma.
  • Immunohistochemical studies revealed nuclear expression of the large T-antigen in a choroid plexus papilloma.
  • CONCLUSIONS: The results of this study provide molecular evidence of the association between JC virus and the development of certain ependymomas and choroid plexus papillomas.
  • [MeSH-minor] Antigens, Viral, Tumor / genetics. Astrocytoma / pathology. Astrocytoma / virology. Base Sequence. Blotting, Southern. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / virology. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / virology. Child. Child, Preschool. Ependymoma / pathology. Ependymoma / virology. Female. Humans. Infant. Male. Medulloblastoma / pathology. Medulloblastoma / virology. Papilloma, Choroid Plexus / pathology. Papilloma, Choroid Plexus / virology. Polymerase Chain Reaction. Supratentorial Neoplasms / pathology. Supratentorial Neoplasms / virology

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  • (PMID = 15881753.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
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13. Van den Hof MC, Wilson RD, Diagnostic Imaging Committee, Society of Obstetricians and Gynaecologists of Canada, Genetics Committee, Society of Obstetricians and Gynaecologists of Canada: Fetal soft markers in obstetric ultrasound. J Obstet Gynaecol Can; 2005 Jun;27(6):592-636
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  • The screening ultrasound at 16 to 20 weeks should evaluate 8 markers, 5 of which (thickened nuchal fold, echogenic bowel, mild ventriculomegaly, echogenic focus in the heart, and choroid plexus cyst) are associated with an increased risk of fetal aneuploidy, and in some cases with nonchromosomal problems, while 3 (single umbilical artery, enlarged cisterna magna, and pyelectasis) are only associated with an increased risk of nonchromosomal abnormalities when seen in isolation (II-2 B).

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  • [CommentIn] J Obstet Gynaecol Can. 2006 Oct;28(10):865-6 [17140500.001]
  • (PMID = 16100637.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng; fre
  • [Publication-type] Guideline; Journal Article; Practice Guideline
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Biomarkers
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14. Grunwald I, Dillmann K, Roth C, Backens M, Reith W: [Supratentorial tumors]. Radiologe; 2007 Jun;47(6):471-85
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  • Further diagnostic procedures as well as the interpretation of the findings vary depending on the tumor location.
  • The supratentorial extracranial tumors include the choroid plexus, colloid cysts, meningeoma, infantile myofibromatosis and lipoma.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Supratentorial Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 17541538.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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15. Jung TY, Jung S: Third ventricular chordoid glioma with unusual aggressive behavior. Neurol Med Chir (Tokyo); 2006 Dec;46(12):605-8
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  • The tumor was subtotally removed via a transcallosal approach.
  • The tumor and hydrocephalus recurred after 3 months.
  • This very short duration before recurrence suggests that neuroimaging follow up may be necessary in patients with subtotally removed choroid glioma.
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17185888.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Kortvely E, Hauck SM, Duetsch G, Gloeckner CJ, Kremmer E, Alge-Priglinger CS, Deeg CA, Ueffing M: ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations. Invest Ophthalmol Vis Sci; 2010 Jan;51(1):79-88
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  • Recent evidence suggests that in patients homozygous for the risk allele, the lack of synthesis of the poorly characterized ARMS2 is causative of this disorder.
  • ARMS2 is mostly confined to choroid pillars in human eyes, representing a part of extracellular matrix and corresponding to the principal sites of drusen formation.

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  • (PMID = 19696174.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARMS2 protein, human; 0 / Antibodies, Monoclonal; 0 / Calcium-Binding Proteins; 0 / Extracellular Matrix Proteins; 0 / HMCN1 protein, human; 0 / Immunoglobulins; 0 / Peptide Fragments; 0 / Proteins; 0 / fibulin
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17. Amaral J, Fariss RN, Campos MM, Robison WG Jr, Kim H, Lutz R, Becerra SP: Transscleral-RPE permeability of PEDF and ovalbumin proteins: implications for subconjunctival protein delivery. Invest Ophthalmol Vis Sci; 2005 Dec;46(12):4383-92
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  • Subconjunctival Fl-PEDF or Fl-ovalbumin administration in vivo revealed movement of full-length protein into the choroid and retina as early as 1 hour.

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  • (PMID = 16303924.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Nerve Growth Factors; 0 / Serpins; 0 / pigment epithelium-derived factor; 9006-59-1 / Ovalbumin; TPY09G7XIR / Fluorescein
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18. Drago A, Serretti A: Focus on HTR2C: A possible suggestion for genetic studies of complex disorders. Am J Med Genet B Neuropsychiatr Genet; 2009 Jul 5;150B(5):601-37
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  • Its role in important brain structures such as the midbrain, the lateral septal complex, the hypothalamus, the olfactory bulb, the pons, the choroid plexus, the nucleus pallidus, the striatum and the amygdala, the nucleus accumbens and the anterior cingulated gyrus candidate it as a promising target for genetic association studies.

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  • [Copyright] 2008 Wiley-Liss, Inc.
  • (PMID = 18802918.001).
  • [ISSN] 1552-485X
  • [Journal-full-title] American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • [ISO-abbreviation] Am. J. Med. Genet. B Neuropsychiatr. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Serotonin, 5-HT2C
  • [Number-of-references] 470
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19. Caldwell JD, Shapiro RA, Jirikowski GF, Suleman F: Internalization of sex hormone-binding globulin into neurons and brain cells in vitro and in vivo. Neuroendocrinology; 2007;86(2):84-93
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  • SHBG uptake was seen in specific parts of the choroid plexus and periventricular cells as well as into cells in the paraventricular nucleus, the medial forebrain bundle, and the habenula.
  • [MeSH-minor] Animals. Cell Line, Tumor. Estrogen Receptor alpha / genetics. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / genetics. Estrogen Receptor beta / metabolism. Female. Glioma. Humans. In Vitro Techniques. Injections, Intraventricular. Iodine Radioisotopes. Lateral Ventricles. Mice. Neuroblastoma. Ovariectomy. Rats. Rats, Sprague-Dawley. Signal Transduction / physiology. Transfection

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17684316.001).
  • [ISSN] 1423-0194
  • [Journal-full-title] Neuroendocrinology
  • [ISO-abbreviation] Neuroendocrinology
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / R21 MH 069810
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Iodine Radioisotopes; 0 / Sex Hormone-Binding Globulin
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20. Parwani AV, Stelow EB, Pambuccian SE, Burger PC, Ali SZ: Atypical teratoid/rhabdoid tumor of the brain: cytopathologic characteristics and differential diagnosis. Cancer; 2005 Apr 25;105(2):65-70
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  • [Title] Atypical teratoid/rhabdoid tumor of the brain: cytopathologic characteristics and differential diagnosis.
  • BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is a highly aggressive neoplasm with a unique cytogenetic profile.
  • Although the clinicopathologic and radiologic features of AT/RT have been described previously, to the authors' knowledge the cytomorphologic profile of this tumor has not been studied well.
  • Cytomorphologic features consisted of hypercellularity (eight of eight tumors); predominantly large tissue fragments with tumor cells surrounding proliferating capillaries depicting a "papillary-like" appearance (five of eight tumors); large, round, "plasmacytoid" cells and characteristic "rhabdoid" cells (i.e., intermediate-sized cells with granular to fibrillary, brightly eosinophilic cytoplasm with or without globoid "inclusions"; large, eccentrically located, round-to-reniform nuclei with single prominent nucleoli; eight of eight tumors); small, round, primitive "neuronal-appearing" cells with a high nuclear to cytoplasmic ratio (five of eight patients); and bizarre, multinucleated giant cells (two of eight tumors).
  • Cytomorphologic features are unique and lead to an accurate diagnosis in the right clinicoradiologic context.
  • The differential diagnosis includes medulloblastoma (in cerebellar tumors), primitive neuroectodermal tumor (in suprasellar tumors), choroid plexus carcinoma, and malignant glioma.
  • [MeSH-major] Brain Neoplasms / pathology. Rhabdoid Tumor / pathology
  • [MeSH-minor] Adolescent. Child, Preschool. Diagnosis, Differential. Female. Glioma / pathology. Humans. Infant. Male. Medulloblastoma / pathology. Neuroectodermal Tumors, Primitive. Retrospective Studies


21. Dietrich MO, Muller A, Bolos M, Carro E, Perry ML, Portela LV, Souza DO, Torres-Aleman I: Western style diet impairs entrance of blood-borne insulin-like growth factor-1 into the brain. Neuromolecular Med; 2007;9(4):324-30
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  • Rats under a cafeteria diet showed reduced passage of systemic IGF-1 across the choroid plexus, a main site of IGF-1 entrance into the brain through the cerebrospinal fluid.
  • Furthermore, the IGF-1 receptor at the choroid plexus of rats fed with a cafeteria diet showed enhanced sensitivity toward IGF-1 while receptor levels remained unchanged.
  • Examination of possible mechanisms underlying reduced entrance of systemic IGF-1 to the brain showed that triglycerides that increased in blood after a cafeteria diet, diminished the passage of IGF-1 across choroid plexus epithelia.
  • This effect of triglycerides was achieved by altering the interaction of IGF-1 with megalin, a choroid plexus transporter involved in transcytosis of IGF-1 from the circulation into the brain.

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  • (PMID = 17999206.001).
  • [ISSN] 1535-1084
  • [Journal-full-title] Neuromolecular medicine
  • [ISO-abbreviation] Neuromolecular Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipids; 67763-96-6 / Insulin-Like Growth Factor I
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22. Tenenbaum T, Essmann F, Adam R, Seibt A, Jänicke RU, Novotny GE, Galla HJ, Schroten H: Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro. Brain Res; 2006 Jul 19;1100(1):1-12
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  • [Title] Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro.
  • The choroid plexus epithelium constitutes the structural basis of the blood-cerebrospinal fluid barrier.
  • We previously demonstrated that Streptococcus suis (S. suis), a relevant cause of bacterial meningitis in pigs and humans, affects porcine choroid plexus epithelial cell (PCPEC) barrier function and integrity.
  • Through inflammation in the choroid plexus during bacterial meningitis, the blood-cerebrospinal fluid barrier function will be compromised.
  • [MeSH-major] Caspases / metabolism. Choroid Plexus / metabolism. Epithelial Cells / metabolism. HMGB1 Protein / metabolism. Streptococcal Infections / metabolism. Streptococcus suis

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  • (PMID = 16781680.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / HMGB1 Protein; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 3.4.22.- / Caspases
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23. Szmydynger-Chodobska J, Chung I, Chodobski A: Chronic hypernatremia increases the expression of vasopressin and voltage-gated Na channels in the rat choroid plexus. Neuroendocrinology; 2006;84(5):339-45
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  • [Title] Chronic hypernatremia increases the expression of vasopressin and voltage-gated Na channels in the rat choroid plexus.
  • The choroid plexus (CP) epithelium is one of the extrahypothalamic sources of arginine vasopressin (AVP).
  • [MeSH-major] Arginine Vasopressin / genetics. Choroid Plexus / metabolism. Hypernatremia / genetics. Sodium Channels / genetics

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  • (PMID = 17164538.001).
  • [ISSN] 0028-3835
  • [Journal-full-title] Neuroendocrinology
  • [ISO-abbreviation] Neuroendocrinology
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS49479
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Protein Subunits; 0 / RNA, Messenger; 0 / Sodium Channels; 113-79-1 / Arginine Vasopressin
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24. Schniederjan MJ, Shehata B, Brat DJ, Esiashvili N, Janss AJ: De novo germline TP53 mutation presenting with synchronous malignancies of the central nervous system. Pediatr Blood Cancer; 2009 Dec 15;53(7):1352-4
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  • [Title] De novo germline TP53 mutation presenting with synchronous malignancies of the central nervous system.
  • We present a case of a 14-year-old male with a germline TP53 mutation who presented with synchronous primitive neuroectodermal tumor and choroid plexus carcinoma.
  • This case identifies a rare, de novo, germline TP53 mutation presenting with synchronous CNS malignancies and exhibiting a more fulminant course than typical cases of Li-Fraumeni syndrome.
  • [MeSH-major] Brain Neoplasms / genetics. Carcinoma / genetics. Choroid Plexus Neoplasms / genetics. Codon, Nonsense. Genes, p53. Germ-Line Mutation. Neoplasms, Multiple Primary / genetics. Neuroectodermal Tumors, Primitive / genetics. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Alveolar / secondary

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19711436.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon, Nonsense; 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine; Q20Q21Q62J / Cisplatin
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25. Mennel S, Hausmann N, Meyer CH, Peter S: Photodynamic therapy and indocyanine green guided feeder vessel photocoagulation of choroidal neovascularization secondary to choroid rupture after blunt trauma. Graefes Arch Clin Exp Ophthalmol; 2005 Jan;243(1):68-71
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  • [Title] Photodynamic therapy and indocyanine green guided feeder vessel photocoagulation of choroidal neovascularization secondary to choroid rupture after blunt trauma.
  • METHODS: A 61-year-old woman developed subfoveal CNV originating from a choroid tear 8 years after blunt head trauma.
  • New feeder vessel formation and growth of CNV in case of traumatic choroid rupture could not be treated effectively by these two laser treatment modalities to prevent severe deterioration of visual acuity.
  • [MeSH-major] Choroid / injuries. Choroidal Neovascularization / therapy. Coloring Agents. Indocyanine Green. Laser Coagulation. Photochemotherapy. Wounds, Nonpenetrating / complications

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  • (PMID = 15660279.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Photosensitizing Agents; 0 / Porphyrins; 0X9PA28K43 / verteporfin; IX6J1063HV / Indocyanine Green
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26. Pälvimäki EP, Majasuo H, Syvälahti E, Hietala J: Serotonin 5-HT2C receptor-mediated phosphoinositide hydrolysis in rat choroid plexus after fluoxetine and citalopram treatments. Pharmacol Res; 2005 May;51(5):419-25
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  • [Title] Serotonin 5-HT2C receptor-mediated phosphoinositide hydrolysis in rat choroid plexus after fluoxetine and citalopram treatments.
  • The present study was conducted in order to determine the effects of acute and chronic fluoxetine and citalopram treatments on the density and function of 5-HT2C receptors in the rat choroid plexus.
  • [MeSH-major] Choroid Plexus / drug effects. Citalopram / pharmacology. Fluoxetine / pharmacology. Phosphatidylinositols / metabolism. Receptor, Serotonin, 5-HT2C / physiology. Serotonin Uptake Inhibitors / pharmacology

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  • (PMID = 15749456.001).
  • [ISSN] 1043-6618
  • [Journal-full-title] Pharmacological research
  • [ISO-abbreviation] Pharmacol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amphetamines; 0 / Ergolines; 0 / Inositol Phosphates; 0 / Phosphatidylinositols; 0 / Receptor, Serotonin, 5-HT2C; 0 / Serotonin 5-HT2 Receptor Agonists; 0 / Serotonin 5-HT2 Receptor Antagonists; 0 / Serotonin Uptake Inhibitors; 01K63SUP8D / Fluoxetine; 0DHU5B8D6V / Citalopram; 64584-34-5 / 4-iodo-2,5-dimethoxyphenylisopropylamine; SML95FK06I / mesulergine
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27. Persson A, Fan X, Widegren B, Englund E: Cell type- and region-dependent coxsackie adenovirus receptor expression in the central nervous system. J Neurooncol; 2006 May;78(1):1-6
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  • The most marked staining positivity was found in the choroid plexus and the pituitary gland.

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  • (PMID = 16314939.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. Machado RA, Brizot ML, Carvalho MH, Waissman AL, Bunduki V, Zugaib M: Sonographic markers of exencephaly below 10 weeks' gestation. Prenat Diagn; 2005 Jan;25(1):31-3
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  • Both cases presented an irregular cephalic pole, and, in the case seen at 8 weeks 4 days, brain vesicles were also absent, whereas in the case seen at 9 weeks 3 days, the midline echo was indistinguishable with disorganized choroid plexuses.
  • In both cases, anencephaly was evident at 11 and 12 weeks' gestation and the postmortem confirmed the diagnosis.

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  • [Copyright] Copyright (c) 2005 John Wiley & Sons, Ltd.
  • [CommentIn] Prenat Diagn. 2005 Jul;25(7):627 [16034839.001]
  • (PMID = 15662695.001).
  • [ISSN] 0197-3851
  • [Journal-full-title] Prenatal diagnosis
  • [ISO-abbreviation] Prenat. Diagn.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Rummer JL, Roshan-Moniri M, Balfry SK, Brauner CJ: Use it or lose it? Sablefish, Anoplopoma fimbria, a species representing a fifth teleostean group where the betaNHE associated with the red blood cell adrenergic stress response has been secondarily lost. J Exp Biol; 2010 May;213(Pt 9):1503-12
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  • Although sablefish lack a SB, we observed a well-defined choroid rete at the eye.
  • However, sablefish have not lost the choroid rete at the eye (unlike in the other four groups), which may still function with the Root effect to oxygenate the retina, but the low pH onset of the Root effect may ensure haemoglobin (Hb)-O(2) binding is not compromised at the respiratory surface during a general acidosis in the absence of RBC betaNHE.
  • The sablefish may represent an anomaly within the framework of Root effect evolution, in that they possess a moderate Root effect and a choroid rete at the eye, but lack the RBC betaNHE and the SB system.

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  • (PMID = 20400635.001).
  • [ISSN] 1477-9145
  • [Journal-full-title] The Journal of experimental biology
  • [ISO-abbreviation] J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Agonists; 0 / Sodium-Hydrogen Antiporter; L628TT009W / Isoproterenol; S88TT14065 / Oxygen
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30. Sangave A, Faia LJ, Yeh S, Chan CC, Nussenblatt RB, Sen HN: A case of rapid progression and vision loss in a patient with primary intraocular lymphoma. Ocul Immunol Inflamm; 2010 Apr;18(2):99-100
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  • RESULTS: Repeat MRI of the brain and orbits at this time revealed a 0.8 x 2.4-cm lesion of the left choroid plexus.
  • [MeSH-major] Blindness / diagnosis. Eye Neoplasms / complications. Lymphoma, B-Cell / complications

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  • (PMID = 20370335.001).
  • [ISSN] 1744-5078
  • [Journal-full-title] Ocular immunology and inflammation
  • [ISO-abbreviation] Ocul. Immunol. Inflamm.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA EY000222-24
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine; YL5FZ2Y5U1 / Methotrexate
  • [Other-IDs] NLM/ NIHMS227987; NLM/ PMC2923390
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31. Israel D, Chua S Jr: Leptin receptor modulation of adiposity and fertility. Trends Endocrinol Metab; 2010 Jan;21(1):10-6
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  • The leptin receptor was discovered as a leptin binding protein, which is highly expressed in the choroid plexus.

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  • (PMID = 19854659.001).
  • [ISSN] 1879-3061
  • [Journal-full-title] Trends in endocrinology and metabolism: TEM
  • [ISO-abbreviation] Trends Endocrinol. Metab.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK057621; United States / NIDDK NIH HHS / DK / DK057621; United States / NIDDK NIH HHS / DK / P30 DK063608-049006; United States / NICHD NIH HHS / HD / U54 HD058155-01A17074; United States / NICHD NIH HHS / HD / 1U54HD058155; United States / NIDDK NIH HHS / DK / R01 DK057621-09; United States / NIDDK NIH HHS / DK / P01DK26687; United States / NIDDK NIH HHS / DK / P30 DK026687; United States / NICHD NIH HHS / HD / U54 HD058155; United States / NIDDK NIH HHS / DK / P30 DK063608
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Leptin
  • [Number-of-references] 67
  • [Other-IDs] NLM/ NIHMS147632; NLM/ PMC2818174
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32. Reyes-Irisarri E, Pérez-Torres S, Miró X, Martínez E, Puigdomènech P, Palacios JM, Mengod G: Differential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expression. Synapse; 2008 Jan;62(1):74-9
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  • Using the systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) as an inflammation model in rats, we found an increase in PDEB2 mRNA expression in choroid plexus.

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17960764.001).
  • [ISSN] 0887-4476
  • [Journal-full-title] Synapse (New York, N.Y.)
  • [ISO-abbreviation] Synapse
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Lipopolysaccharides; 0 / RNA, Messenger; EC 3.1.4.17 / Cyclic Nucleotide Phosphodiesterases, Type 4
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33. Boxma A, Lequin M, Ramenghi LA, Kros M, Govaert P: Sonographic detection of the optic radiation. Acta Paediatr; 2005 Oct;94(10):1455-61
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  • For each infant, one first week standard coronal image was used for measurement of grey values around the para-atrial region of interest (PAROI) relative to the choroid plexus.
  • RESULTS: The hyperechoic para-atrial area, subjectively detected in 84% of the patients, was situated bilaterally between the inner end of the lateral fissure and the upper third of the choroid plexus.
  • The average ratio of grey value around the PAROI to the choroid plexus was 0.787 (SD = 0.072, median 0.791).
  • [MeSH-major] Chorioamnionitis / ultrasonography. Choroid Plexus / ultrasonography. Infant, Premature, Diseases / ultrasonography. Lateral Ventricles / ultrasonography. Leukomalacia, Periventricular / ultrasonography
  • [MeSH-minor] Adult. Brain Diseases / diagnosis. Cohort Studies. Diagnosis, Differential. Female. Fetal Development / physiology. Gestational Age. Humans. Infant, Newborn. Infant, Premature. Intensive Care Units, Neonatal. Magnetic Resonance Imaging. Male. Observer Variation. Pregnancy. Sensitivity and Specificity. Ultrasonography, Doppler

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  • (PMID = 16299877.001).
  • [ISSN] 0803-5253
  • [Journal-full-title] Acta paediatrica (Oslo, Norway : 1992)
  • [ISO-abbreviation] Acta Paediatr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Norway
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34. Mongkolrattanothai K, Ramakrishnan S, Zagardo M, Gray B: Ventriculitis and choroid plexitis caused by multidrug-resistant Nocardia pseudobrasiliensis. Pediatr Infect Dis J; 2008 Jul;27(7):666-8
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  • [Title] Ventriculitis and choroid plexitis caused by multidrug-resistant Nocardia pseudobrasiliensis.
  • We describe a case of ventriculitis and choroid plexitis caused by a multidrug-resistant Nocardia pseudobrasiliensis in an immunocompetent child.
  • Difficulties establishing an etiologic diagnosis, inconsistencies of antibiotic susceptibility testing, and the side effects of various antimicrobials presented challenges to her treatment and eventual favorable outcome.
  • [MeSH-major] Cerebral Ventricles / microbiology. Cerebral Ventricles / pathology. Drug Resistance, Multiple, Bacterial. Encephalitis / microbiology. Nocardia / isolation & purification. Nocardia Infections / diagnosis

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  • (PMID = 18520971.001).
  • [ISSN] 0891-3668
  • [Journal-full-title] The Pediatric infectious disease journal
  • [ISO-abbreviation] Pediatr. Infect. Dis. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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35. Gorbatov M, Miller J, Yu PK, Cringle SJ, Yu DY: Ablation of subretinal tissue with optical fiber delivered 266 nm laser pulses. Exp Eye Res; 2010 Aug;91(2):257-63
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  • Choroid segments dissected from fresh porcine eyes, with or without the retinal pigment epithelium (RPE), were clamped in a fluid bath.
  • Lower radiation doses did not disrupt Bruch's membrane, but did damage the choroidal tissue and produce vacuoles in the underlying choroid.
  • The full thickness of the choroid was ablated by 200 pulses of 0.40 J/cm(2).
  • [MeSH-major] Bruch Membrane / radiation effects. Choroid / radiation effects. Lasers, Solid-State / adverse effects. Optical Fibers. Radiation Injuries, Experimental / etiology. Retinal Pigment Epithelium / radiation effects. Ultraviolet Rays

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20510242.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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36. Zhang YS, Yao L, Hao YL, Zou Y, Xu HJ, Fan QY: [Preliminary study of biomarker in blood or cerebrospinal fluid of rat following manganese exposure]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2010 Mar;28(3):186-9
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  • However the trend and range of Mn increase in cerebrospinal fluid (CSF) was the same as that in brain tissue including striatum, cortex, hippocampus and choroid plexus.

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  • (PMID = 20635692.001).
  • [ISSN] 1001-9391
  • [Journal-full-title] Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
  • [ISO-abbreviation] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antimicrobial Cationic Peptides; 0 / Cation Transport Proteins; 0 / Hamp protein, rat; 0 / Hepcidins; 0 / RNA, Messenger; 0 / solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2; 42Z2K6ZL8P / Manganese; E1UOL152H7 / Iron; EC 6.3.2.19 / Ubiquitin-Protein Ligases; EC 6.3.2.19 / parkin protein
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37. Runkel F, Büssow H, Seburn KL, Cox GA, Ward DM, Kaplan J, Franz T: Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25. Mamm Genome; 2006 Mar;17(3):203-10
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  • Melanosomes of melanocytes associated with hair follicles and the choroid layer of the eye, as well as melanosomes in the neural tube-derived pigment epithelium of the retina, were larger and irregularly shaped in homozygous mutants compared with those of wild-type controls.
  • RT-PCR analyses revealed the skipping of exon 25 in Lyst(bg-grey) mutants, which is predicted to cause a missense D2399E mutation and the loss of the following 77 amino acids encoded by exon 25 but leave the C-terminal end of the protein intact.


38. Fuchsjäger-Mayrl G, Wally B, Rainer G, Buehl W, Aggermann T, Kolodjaschna J, Weigert G, Polska E, Eichler HG, Vass C, Schmetterer L: Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension. Br J Ophthalmol; 2005 Oct;89(10):1293-7
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  • CONCLUSIONS: This study indicates augmented blood flow in the optic nerve head and choroid after 6 months of treatment with dorzolamide, but not with timolol.
  • [MeSH-minor] Aged. Choroid / blood supply. Double-Blind Method. Female. Glaucoma, Open-Angle / drug therapy. Glaucoma, Open-Angle / physiopathology. Heart Rate / drug effects. Hemodynamics / drug effects. Humans. Intraocular Pressure / drug effects. Laser-Doppler Flowmetry. Male. Middle Aged. Optic Disk / blood supply. Regional Blood Flow / drug effects. Regression Analysis. Retinal Vessels / drug effects

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  • (PMID = 16170119.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Sulfonamides; 0 / Thiophenes; 817W3C6175 / Timolol; 9JDX055TW1 / dorzolamide
  • [Other-IDs] NLM/ PMC1772863
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39. Poché RA, Larina IV, Scott ML, Saik JE, West JL, Dickinson ME: The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease. Dev Dyn; 2009 Sep;238(9):2318-26
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  • Here, we demonstrate that the Flk1-myr::mCherry transgenic mouse is an extremely useful live reporter with broad applicability to retinal, hyaloid, and choroid vascular research.

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  • [Copyright] 2009 Wiley-Liss, Inc.
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  • (PMID = 19253403.001).
  • [ISSN] 1097-0177
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / P20EB007076; United States / NICHD NIH HHS / HD / T32 HD055200; United States / NHLBI NIH HHS / HL / R01 HL097520; United States / NEI NIH HHS / EY / T32EY07102; United States / NHLBI NIH HHS / HL / R01HL077187; United States / NIBIB NIH HHS / EB / R01 EB005173; United States / NHLBI NIH HHS / HL / R01 HL077187; United States / NHLBI NIH HHS / HL / HL077187-03; United States / NHLBI NIH HHS / HL / R01 HL077187-03; United States / NIBIB NIH HHS / EB / R01EB005173-01/05; United States / NEI NIH HHS / EY / R21 EY020632; United States / NICHD NIH HHS / HD / T32HD055200; United States / NIBIB NIH HHS / EB / P20 EB007076; United States / NEI NIH HHS / EY / T32 EY007102
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Other-IDs] NLM/ NIHMS90807; NLM/ PMC2901875
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40. Yu DY, Cringle SJ: Oxygen distribution in the mouse retina. Invest Ophthalmol Vis Sci; 2006 Mar;47(3):1109-12
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  • METHODS: Oxygen-sensitive microelectrodes were used to measure oxygen tension as a function of depth through the retina and choroid in anesthetized mice (n = 8).

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  • (PMID = 16505048.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] S88TT14065 / Oxygen
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41. Wollack JB, Makori B, Ahlawat S, Koneru R, Picinich SC, Smith A, Goldman ID, Qiu A, Cole PD, Glod J, Kamen B: Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model. J Neurochem; 2008 Mar;104(6):1494-503
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  • [Title] Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model.
  • Choroid plexus epithelial cells express high levels of folate receptor alpha (FRalpha) suggesting that the choroid plays an important role in CNS folate trafficking and maintenance of CSF folate levels.
  • We have characterized 5-methyltetrahydrofolate (5-MTHF) uptake and metabolism by primary rat choroid plexus epithelial cells in vitro.
  • The proton-coupled folate transporter, proton-coupled folate transporter (PCFT), mRNA was also shown to be expressed in choroid plexus epithelial cells.
  • [MeSH-major] Choroid Plexus / cytology. Epithelial Cells / metabolism. Folic Acid / pharmacokinetics. Vitamin B Complex / pharmacokinetics

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  • (PMID = 18086128.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-82621
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Cell Cycle Proteins; 0 / Folate Receptors, GPI-Anchored; 0 / Receptors, Cell Surface; 0 / Tetrahydrofolates; 10028-17-8 / Tritium; 12001-76-2 / Vitamin B Complex; 134-35-0 / 5-methyltetrahydrofolate; 935E97BOY8 / Folic Acid; EC 3.1.- / Endodeoxyribonucleases; EC 3.1.- / mENase protein, Coprinus cinereus
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42. Joó JG, Tóth Z, Beke A, Papp C, Tóth-Pál E, Csaba A, Szigeti Z, Rab A, Papp Z: Etiology, prenatal diagnostics and outcome of ventriculomegaly in 230 cases. Fetal Diagn Ther; 2008;24(3):254-63
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  • The main diagnostic criterion for ventriculomegaly was the transverse diameter of the ventricular atrium at the level of the glomus of the chorioid plexus measuring >10 mm, irrespective of gestational age.
  • Based on the ultrasonographic diagnosis of ventriculomegaly, TORCH serological examination is also recommended since treating toxoplasmosis by medication may have a promising prognosis for the pregnancy.

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18765939.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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43. Kanoski SE, Zhang Y, Zheng W, Davidson TL: The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis; 2010;21(1):207-19
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  • We found that HE-diet consumption produced a decrease in mRNA expression of tight junction proteins, particularly Claudin-5 and -12, in the choroid plexus and the BBB.

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  • (PMID = 20413889.001).
  • [ISSN] 1875-8908
  • [Journal-full-title] Journal of Alzheimer's disease : JAD
  • [ISO-abbreviation] J. Alzheimers Dis.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES017055; United States / NICHD NIH HHS / HD / R01HD44179; United States / NIEHS NIH HHS / ES / ES008146; United States / NIEHS NIH HHS / ES / R01 ES008146; United States / NICHD NIH HHS / HD / R01 HD044179; United States / NICHD NIH HHS / HD / R01 HD028792; United States / NICHD NIH HHS / HD / R01 HD29792; United States / NIEHS NIH HHS / ES / R21 ES017055; United States / NICHD NIH HHS / HD / P01 HD052112; United States / NIEHS NIH HHS / ES / R56 ES008146
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dietary Fats; 0 / Membrane Proteins
  • [Other-IDs] NLM/ NIHMS806439; NLM/ PMC4975946
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44. Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K: Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization. Invest Ophthalmol Vis Sci; 2009 Sep;50(9):4410-5
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  • The mRNA expression of CD44 and HA synthase (HAS)-2 in the retinal pigment epithelium (RPE)-choroid complex was evaluated by DNA microarray and real-time RT-PCR analyses 3 days after laser treatment.
  • [MeSH-minor] Animals. Antibodies, Blocking / pharmacology. Choroid / metabolism. Disease Models, Animal. Dose-Response Relationship, Drug. Fluorescent Antibody Technique, Indirect. Gene Expression Profiling. Glucuronosyltransferase / genetics. Hymecromone / analogs & derivatives. Hymecromone / pharmacology. Macrophages / physiology. Male. Mice. Mice, Inbred C57BL. Oligonucleotide Array Sequence Analysis. RNA, Messenger / metabolism. Retinal Pigment Epithelium / metabolism. Reverse Transcriptase Polymerase Chain Reaction


45. Primavera V, Querques G, Guigui B, Turco I, Iaculli C, Russo V, Delle Noci N: [Choroidal metastasis from clinically regressed prostate adenocarcinoma: imaging of a rare case]. J Fr Ophtalmol; 2008 Nov;31(9):877-82
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  • [Transliterated title] Métastase choroïdienne d'un adénocarcinome de la prostate: iconographie d'un cas rare.
  • Fluorescein angiography, indocyanine-green angiography, and optical coherence tomography are useful tools in the diagnosis and follow-up of prostatic adenocarcinoma metastatic to the choroid.
  • [MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Prostatic Neoplasms / pathology

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  • (PMID = 19107059.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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46. Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM: Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol; 2008 Jun;294(6):F1422-32
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  • Our results strongly suggest that the protein does not operate as a cotransporter in tissues where there is little or no pH gradient, such as choroid plexus, lung, or mammary gland.

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  • (PMID = 18367661.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-19567; United States / NIGMS NIH HHS / GM / GM-61390
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antineoplastic Agents; 0 / Dipeptides; 0 / Oligopeptides; 0 / Protons; 0 / SLC15A1 protein, human; 0 / Symporters; 0 / hydrogen-coupled oligopeptide transporter PepT2; 10028-17-8 / Tritium; 280111G160 / Cefadroxil; 29816-01-1 / glycylsarcosine; 88755TAZ87 / Aminolevulinic Acid
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47. Mitchell SE, Nogueiras R, Rance K, Rayner DV, Wood S, Dieguez C, Williams LM: Circulating hormones and hypothalamic energy balance: regulatory gene expression in the Lou/C and Wistar rats. J Endocrinol; 2006 Sep;190(3):571-9
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  • There was no difference in Ob-R gene expression in, or [(125)I]leptin binding to, the choroid plexus.
  • [MeSH-minor] Agouti-Related Protein. Animals. Choroid Plexus / chemistry. Choroid Plexus / metabolism. Corticosterone / blood. Gene Expression. Ghrelin. In Situ Hybridization / methods. Insulin / blood. Intercellular Signaling Peptides and Proteins / genetics. Leptin / blood. Leptin / pharmacology. Neuropeptide Y / genetics. Peptide Hormones / blood. Protein Binding. Random Allocation. Rats. Rats, Mutant Strains. Rats, Wistar. Receptors, Cell Surface / metabolism. Receptors, Leptin. Suppressor of Cytokine Signaling Proteins / metabolism. Thyrotropin / blood. Thyroxine / blood. Triiodothyronine / blood

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  • (PMID = 17003258.001).
  • [ISSN] 0022-0795
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Agouti-Related Protein; 0 / Ghrelin; 0 / Hypothalamic Hormones; 0 / Insulin; 0 / Intercellular Signaling Peptides and Proteins; 0 / Leptin; 0 / Neuropeptide Y; 0 / Peptide Hormones; 0 / Receptors, Cell Surface; 0 / Receptors, Leptin; 0 / Socs3 protein, rat; 0 / Suppressor of Cytokine Signaling Proteins; 06LU7C9H1V / Triiodothyronine; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine; W980KJ009P / Corticosterone
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48. Soni V, Kohli DV, Jain SK: Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil. J Drug Target; 2005 May;13(4):245-50
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  • Complex multi-strand tight junctions between adjacent cerebral endothelial cells and between choroid plexus epithelial cells form a physical barrier and prevent the passage of water soluble drugs from the blood into the brain, whereas the inward passage of lipid soluble drugs is restricted by drug efflux pumps which act as a functional barrier.

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  • (PMID = 16051536.001).
  • [ISSN] 1061-186X
  • [Journal-full-title] Journal of drug targeting
  • [ISO-abbreviation] J Drug Target
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ligands; 0 / Liposomes; 0 / Transferrin; U3P01618RT / Fluorouracil; VW78417PU1 / Technetium Tc 99m Pentetate
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49. Parris JJ, Cooke VG, Skarnes WC, Duncan MK, Naik UP: JAM-A expression during embryonic development. Dev Dyn; 2005 Aug;233(4):1517-24
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  • In addition, JAM-A gene activity was found in the developing liver, choroid plexuses, and gut tubes.

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15977176.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY012221; United States / NEI NIH HHS / EY / EY015279; United States / NHLBI NIH HHS / HL / HL63960; United States / NCRR NIH HHS / RR / P20 RR16472
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / F11r protein, mouse; 0 / Receptors, Cell Surface
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50. Schmidt-Erfurth U, Niemeyer M, Geitzenauer W, Michels S: Time course and morphology of vascular effects associated with photodynamic therapy. Ophthalmology; 2005 Dec;112(12):2061-9
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  • Changes at the level of the CNV lesion and the collateral choroid were documented over time with respect to vascular closure, leakage resulting from vascular barrier breakdown, and alteration of physiologic perfusion.
  • At 5 hours after verteporfin therapy, 3-dimensional FA identified an extensive increase in hyperfluorescent prominence as well as lesion extension in most verteporfin-treated eyes (65%), resulting from increased permeability and leakage due to a vascular barrier breakdown in the collateral choroid.
  • Simultaneously, documented best by 3-dimensional ICGA, TAG demonstrated perfusion defects within the adjacent choroid, which started as early as 1 day after verteporfin therapy and persisted during extended follow-up.
  • CONCLUSIONS: Three-dimensional angiography demonstrates a characteristic sequence of changes in the vascular architecture of the CNV lesion and the collateral choroid after verteporfin therapy.
  • Choroidal neovascularization occlusion is associated with immediate massive exudation and is followed by occlusive effects within the collateral choroid.
  • [MeSH-major] Choroid / blood supply. Choroid / pathology. Choroidal Neovascularization / pathology. Macular Degeneration / pathology. Photochemotherapy

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  • (PMID = 16325705.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Photosensitizing Agents; 0 / Porphyrins; 129497-78-5 / verteporfin; IX6J1063HV / Indocyanine Green
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51. Shamji MF, Vassilyadi M, Lam CH, Montes JL, Farmer JP: Congenital tumors of the central nervous system: the MCH experience. Pediatr Neurosurg; 2009;45(5):368-74
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  • METHODS: A retrospective review was performed of congenital brain tumor patients surgically treated at the Montreal Children's Hospital (MCH) over a 22-year period.
  • Median age (p = 0.93) and gender (p = 0.57) did not differ by location, and predominant histologies were choroid plexus papilloma and primitive neuroectodermal tumor.
  • CONCLUSIONS: Congenital brain tumor patients represent fewer than 2% of patients treated at MCH.
  • [MeSH-major] Brain Neoplasms / surgery. Decompression, Surgical. Laminectomy. Papilloma, Choroid Plexus / surgery. Rhabdoid Tumor / surgery. Spinal Neoplasms / surgery

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19907201.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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52. Bonanomi MT, Almeida MT, Cristofani LM, Odone Filho V: Retinoblastoma: a three-year-study at a Brazilian medical school hospital. Clinics (Sao Paulo); 2009 May;64(5):427-34
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  • The mean age at diagnosis was 33.8 months for unilateral cases, and 19.15 months for bilateral cases (p=0.015).
  • In unilateral and bilateral disease, pathology data revealed choroid involvement in 50% and 30%, respectively, and optic nerve invasion in 92% and 50%, respectively.

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53. Nakata K, Crabb JW, Hollyfield JG: Crystallin distribution in Bruch's membrane-choroid complex from AMD and age-matched donor eyes. Exp Eye Res; 2005 Jun;80(6):821-6
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  • [Title] Crystallin distribution in Bruch's membrane-choroid complex from AMD and age-matched donor eyes.
  • Here we compare the distribution of several crystallins in drusen, Bruch's membrane and choroid from AMD and non-AMD age-matched control eyes.
  • [MeSH-major] Bruch Membrane / chemistry. Choroid / chemistry. Crystallins / analysis. Macular Degeneration / metabolism

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  • (PMID = 15939038.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 014239; United States / NEI NIH HHS / EY / EY 014240; United States / NEI NIH HHS / EY / EY 015638
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Crystallins; 0 / alpha-Crystallin A Chain; 0 / alpha-Crystallin B Chain
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54. Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Rickman CB, Bok D, Hageman GS, Johnson LV: The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res; 2010 Mar;29(2):95-112
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  • Third, we identify and characterize the local complement system in the RPE-choroid complex - thus adding a new dimension of biological complexity to the role of the complement system in ocular aging and AMD.

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
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  • (PMID = 19961953.001).
  • [ISSN] 1873-1635
  • [Journal-full-title] Progress in retinal and eye research
  • [ISO-abbreviation] Prog Retin Eye Res
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R24 EY017404-01; United States / NEI NIH HHS / EY / R24 EY014799; United States / NEI NIH HHS / EY / EY014799-05; United States / NEI NIH HHS / EY / P30 EY005722; United States / NEI NIH HHS / EY / P30 EY000331-42S19002; United States / NEI NIH HHS / EY / EY017404-02; United States / NEI NIH HHS / EY / R24 EY017404-04; United States / NEI NIH HHS / EY / P30 EY005722-24; United States / NEI NIH HHS / EY / R24 EY017404-02; United States / NEI NIH HHS / EY / EY014799; United States / NEI NIH HHS / EY / P30 EY000331; United States / NEI NIH HHS / EY / EY005722-24; United States / NEI NIH HHS / EY / R24 EY017404-03; United States / NEI NIH HHS / EY / EY011286-10; United States / NEI NIH HHS / EY / EY000331-42S19002; United States / NEI NIH HHS / EY / EY00331; United States / NEI NIH HHS / EY / EY017404-01; United States / NEI NIH HHS / EY / R24 EY017404; United States / NEI NIH HHS / EY / R01 EY011286; United States / NEI NIH HHS / EY / EY017404-04; United States / NEI NIH HHS / EY / R24 EY014799-05; United States / NEI NIH HHS / EY / R01 EY011286-10; United States / NEI NIH HHS / EY / EY017404-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 9007-36-7 / Complement System Proteins
  • [Number-of-references] 116
  • [Other-IDs] NLM/ NIHMS163756; NLM/ PMC3641842
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55. Warren FM, Shelton C, Wiggins RH 3rd, Herrod HC, Harnsberger HR: Imaging characteristics of metastatic lesions to the cerebellopontine angle. Otol Neurotol; 2008 Sep;29(6):835-8
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  • There were several identifiable patterns of metastases to the CPA/IAC, including the flocculus (5), pia/arachnoid (12), dura (7), and choroid plexus (3).
  • Characteristics that differentiate metastatic lesions from benign lesions of the CPA include vasogenic edema on T2 and FLAIR imaging and multiple central nervous system lesions and lesions that are eccentric to the IAC.
  • CONCLUSION: Recognizing characteristic patterns of spread to the CPA and IAC can aid the clinician in the diagnosis of metastatic lesions to this area.

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  • (PMID = 18636029.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Barry RJ, de Moura LR, Marshall JC, Fernandes BF, Orellana ME, Antecka E, Martins C, Burnier MN: Expression of C-kit in retinoblastoma: a potential therapeutic target. Br J Ophthalmol; 2007 Nov;91(11):1532-6
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  • Immunoreactivity was correlated with the presence or absence of invasion into the choroid and optic nerve and the degree of tumour differentiation.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Proto-Oncogene Proteins c-kit / metabolism. Retinal Neoplasms / metabolism. Retinoblastoma / metabolism
  • [MeSH-minor] Cell Differentiation. Child. Child, Preschool. Choroid / pathology. Female. Humans. Immunoenzyme Techniques. Infant. Male. Neoplasm Invasiveness. Optic Nerve / pathology. Prognosis

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  • (PMID = 17591671.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ PMC2095433
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57. Kubo Y, Ogasawara K, Kakino S, Kashimura H, Yoshida K, Ogawa A: Cerebrospinal fluid adrenomedullin concentration correlates with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage. Cerebrovasc Dis; 2008;25(1-2):164-9
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  • BACKGROUND: Adrenomedullin (AM), a vasorelaxant peptide, is secreted into the cerebrospinal fluid (CSF) from the choroid plexus and can exert natriuretic effects in the kidney.

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18212522.001).
  • [ISSN] 1421-9786
  • [Journal-full-title] Cerebrovascular diseases (Basel, Switzerland)
  • [ISO-abbreviation] Cerebrovasc. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 114471-18-0 / Natriuretic Peptide, Brain; 148498-78-6 / Adrenomedullin; 85637-73-6 / Atrial Natriuretic Factor
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58. Boedtkjer E, Praetorius J, Füchtbauer EM, Aalkjaer C: Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice. Am J Physiol Cell Physiol; 2008 Feb;294(2):C591-603
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  • We find that the NBCn1 promoter is active in a number of tissues where NBCn1 has previously been functionally or immunohistochemically identified, including a broad range of blood vessels (vascular smooth muscle cells and endothelial cells), kidney thick ascending limb and medullary collecting duct epithelial cells, the epithelial lining of the kidney pelvis, duodenal enterocytes, choroid plexus epithelial cells, hippocampus, and retina.

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  • (PMID = 18077606.001).
  • [ISSN] 0363-6143
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Slc4a7 protein, mouse; 0 / Sodium-Bicarbonate Symporters
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59. Ishunina TA, van Beurden D, van der Meulen G, Unmehopa UA, Hol EM, Huitinga I, Swaab DF: Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease. Neurobiol Aging; 2005 Feb;26(2):173-94
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  • In addition, P-450arom-ir was clearly diminished in ependymal and choroid plexus cells in AD.

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  • (PMID = 15582747.001).
  • [ISSN] 0197-4580
  • [Journal-full-title] Neurobiology of aging
  • [ISO-abbreviation] Neurobiol. Aging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / RNA, Messenger; EC 1.14.14.1 / Aromatase
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60. Vasconcellos LP, Santos AR, Veiga JC, Schilemann I, Lancellotti CL: Supratentorial intraventricular schwannoma of the choroid plexus. Arq Neuropsiquiatr; 2009 Dec;67(4):1100-2
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  • [Title] Supratentorial intraventricular schwannoma of the choroid plexus.
  • [MeSH-major] Choroid Plexus Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 20069228.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Brazil
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61. Buckle C, Smith JK: Choroid plexus papilloma of the third ventricle. Pediatr Radiol; 2007 Jul;37(7):725
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  • [Title] Choroid plexus papilloma of the third ventricle.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Magnetic Resonance Imaging. Papilloma, Choroid Plexus / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Male

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  • (PMID = 17464502.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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62. Yorty JL, Tevethia SS, Schell TD: Rapid accumulation of adoptively transferred CD8+ T cells at the tumor site is associated with long-term control of SV40 T antigen-induced tumors. Cancer Immunol Immunother; 2008 Jun;57(6):883-95
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  • [Title] Rapid accumulation of adoptively transferred CD8+ T cells at the tumor site is associated with long-term control of SV40 T antigen-induced tumors.
  • We previously established a model to study CD8(+) T cell (T(CD8))-based adoptive immunotherapy of cancer using line SV11 mice that develop choroid plexus tumors in the brain due to transgenic expression of Simian Virus 40 large T antigen (Tag).
  • In the current study, we compared the kinetics and magnitude of Tag-specific T(CD8) accumulation at the tumor site following adoptive transfer with a high dose of either Tag-immune or naïve donor cells or decreasing doses of Tag-immune lymphocytes.
  • A similar delay in the peak of epitope IV-specific T(CD8) accumulation was observed when tenfold fewer Tag-immune donor cells were administered, reducing control of tumor progression.
  • We also provide evidence that although multiple specificities are represented in the Tag immune donor lymphocytes, epitope IV-specific donor T(CD8) play a predominant role in control of tumor growth.

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  • (PMID = 18004562.001).
  • [ISSN] 0340-7004
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R37 CA025000; United States / NCI NIH HHS / CA / R01 CA025000-30; United States / NCI NIH HHS / CA / R01 CA025000; United States / NCI NIH HHS / CA / CA25000; None / None / / R01 CA025000-30
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Polyomavirus Transforming; 0 / Cytokines; 0 / Epitopes; 0 / Peptides
  • [Other-IDs] NLM/ NIHMS237232; NLM/ PMC2958109
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63. Wang X, Li GJ, Zheng W: Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Brain Res; 2006 Jun 30;1097(1):1-10
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  • This study was designed to test the hypothesis that Mn treatment, by acting on protein-mRNA binding between IRP and DMT1 mRNA, altered the expression of DMT1 in an immortalized choroidal epithelial Z310 cell line which was derived from rat choroid plexus epithelia, leading to a compartmental shift of Fe from the blood to the CSF.

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  • (PMID = 16729984.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R01 ES008146; United States / NIEHS NIH HHS / ES / R21 ES013118; United States / NIEHS NIH HHS / ES / ES013118; United States / NIEHS NIH HHS / ES / ES08164
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cation Transport Proteins; 0 / Iron-Binding Proteins; 0 / RNA, Messenger; 0 / solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2; 42Z2K6ZL8P / Manganese
  • [Other-IDs] NLM/ NIHMS568464; NLM/ PMC3980874
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64. Galt JR, Halkar RK, Evans CO, Osman NA, LaBorde D, Fox TH, Faraj BA, Kumar K, Wang H, Oyesiku NM: In vivo assay of folate receptors in nonfunctional pituitary adenomas with 99mTc-folate SPECT/CT. J Nucl Med; 2010 Nov;51(11):1716-23
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  • Receiver-operating-characteristic curve analysis of quantitative uptake yielded a tumor-to-background cutoff ratio of 3.5, with a sensitivity of 81% and specificity of 83%.
  • Scalp uptake yielded consistent results (over the brain, neck, and choroid plexus) for background when SPECT/CT misalignment artifacts were avoided.
  • [MeSH-major] Folate Receptors, GPI-Anchored / metabolism. Folic Acid / drug effects. Organotechnetium Compounds. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / metabolism. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 20956474.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS051439-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Folate Receptors, GPI-Anchored; 0 / Organotechnetium Compounds; 935E97BOY8 / Folic Acid
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65. Ren X, Zhou L, Terwilliger R, Newton SS, de Araujo IE: Sweet taste signaling functions as a hypothalamic glucose sensor. Front Integr Neurosci; 2009;3:12
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  • Expression was also observed in the intra-ventricular epithelial cells of the choroid plexus.


66. Wang L, Lin M: A novel cell wall-anchored peptidoglycan hydrolase (autolysin), IspC, essential for Listeria monocytogenes virulence: genetic and proteomic analysis. Microbiology; 2008 Jul;154(Pt 7):1900-13
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  • The findings that (i) the mutant was impaired for adhesion to certain eukaryotic cells, and (ii) both purified IspC and its C-terminal cell wall-binding domain were capable of binding sheep choroid plexus (SCP) epithelial cells and Vero cells, supported the role of IspC as an adhesin in virulence.
  • [MeSH-minor] Animals. Bacterial Adhesion. Cell Line, Tumor. Cercopithecus aethiops. Choroid Plexus / microbiology. Endothelial Cells / microbiology. Gene Expression Regulation, Bacterial. Humans. Mice. Mice, Inbred BALB C. Phenotype. Protein Binding. Protein Structure, Tertiary. Sequence Deletion. Sheep. Species Specificity. Vero Cells. Virulence. Virulence Factors / genetics. Virulence Factors / metabolism

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  • (PMID = 18599819.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Virulence Factors; EC 3.5.1.28 / N-Acetylmuramoyl-L-alanine Amidase
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67. Aydin A, Yilmaz S, Ozkan ZE, Ilgün R: Morphological investigations on the circulus arteriosus cerebri in mole-rats (Spalax leucodon). Anat Histol Embryol; 2008 Jun;37(3):219-22
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  • The branches supplying the medulla oblongata and the cerebellum originate from the basilar artery formed by union of the left and right vertebral arteries and the internal ophthalmic, the caudal cerebral, the choroid, the median cerebral, the rostral cerebral arteries originated from the internal carotid artery.

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  • (PMID = 18215205.001).
  • [ISSN] 1439-0264
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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68. Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Usui Y, Kurihara T, Koto T, Satofuka S, Shinoda H, Ozawa Y, Tsubota K, Kawakami Y, Ishida S: Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2. Invest Ophthalmol Vis Sci; 2007 Oct;48(10):4795-801
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  • One week after photocoagulation, mice were killed to harvest the choroid and splenocytes.
  • To confirm the specific immunogenicity of the epitope peptides in C57BL/6 mice, CD8 T cells isolated from harvested splenocytes were restimulated to measure interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha production through enzyme-linked immunospot assay and ELISA.
  • [MeSH-minor] Animals. CD4-Positive T-Lymphocytes. CD8-Positive T-Lymphocytes / immunology. Cytotoxicity, Immunologic. Disease Models, Animal. Dose-Response Relationship, Drug. Enzyme-Linked Immunosorbent Assay. Epitopes / immunology. Flow Cytometry. Immunity, Cellular. Interferon-gamma / metabolism. Lymphocyte Depletion. Male. Mice. Mice, Inbred C57BL. T-Lymphocytes, Cytotoxic / immunology. Tumor Necrosis Factor-alpha / metabolism. Vaccines, Subunit / administration & dosage

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  • (PMID = 17898306.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Epitopes; 0 / Oligopeptides; 0 / Tumor Necrosis Factor-alpha; 0 / Vaccines, Subunit; 82115-62-6 / Interferon-gamma; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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69. Steiner J, Bernstein HG, Bielau H, Berndt A, Brisch R, Mawrin C, Keilhoff G, Bogerts B: Evidence for a wide extra-astrocytic distribution of S100B in human brain. BMC Neurosci; 2007;8:2
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  • S100B was also found in ependymal cells, the choroid plexus epithelium, vascular endothelial cells, lymphocytes, and several neurones.

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  • (PMID = 17199889.001).
  • [ISSN] 1471-2202
  • [Journal-full-title] BMC neuroscience
  • [ISO-abbreviation] BMC Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nerve Growth Factors; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins; 0 / S100B protein, human
  • [Other-IDs] NLM/ PMC1769505
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70. Ahmed AE, Campbell GA, Jacob S: Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts. Neurotoxicology; 2005 Aug;26(4):633-40
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  • Immunohistochemical labeling (TUNEL) of apoptotic nuclei in the cortices and choroid plexuses were also increased in treated animals as compared to control.

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  • (PMID = 16112326.001).
  • [ISSN] 0161-813X
  • [Journal-full-title] Neurotoxicology
  • [ISO-abbreviation] Neurotoxicology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Acetonitriles; 0 / Aldehydes; 0 / Disinfectants; 29343-52-0 / 4-hydroxy-2-nonenal; 4Y8F71G49Q / Malondialdehyde; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; CN524K9DXD / chloroacetonitrile; G9481N71RO / Deoxyguanosine; GAN16C9B8O / Glutathione
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71. Araki M: Regeneration of the amphibian retina: role of tissue interaction and related signaling molecules on RPE transdifferentiation. Dev Growth Differ; 2007 Feb;49(2):109-20
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  • It was revealed that tissue interactions between the retinal pigmented epithelium and underlying connective tissues (the choroid) play a substantial role in transdifferentiation and that this is mediated by a diffusible signal such as fibroblast growth factor 2.

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  • (PMID = 17335432.001).
  • [ISSN] 0012-1592
  • [Journal-full-title] Development, growth & differentiation
  • [ISO-abbreviation] Dev. Growth Differ.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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72. Yokel RA: Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. J Alzheimers Dis; 2006 Nov;10(2-3):223-53
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  • Metal flux across the blood-brain barrier (the primary route of brain metal uptake) and the choroid plexuses as well as sensory nerve metal uptake from the nasal cavity are reviewed.

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  • (PMID = 17119290.001).
  • [ISSN] 1387-2877
  • [Journal-full-title] Journal of Alzheimer's disease : JAD
  • [ISO-abbreviation] J. Alzheimers Dis.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / 1 S15 ES06690; United States / NIEHS NIH HHS / ES / ES K04 174; United States / FIC NIH HHS / TW / F 06 TW02343
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Membrane Transport Proteins; 42Z2K6ZL8P / Manganese; 789U1901C5 / Copper; CPD4NFA903 / Aluminum; E1UOL152H7 / Iron; FXS1BY2PGL / Mercury; J41CSQ7QDS / Zinc
  • [Number-of-references] 285
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73. Chi ZH, Wang X, Wang ZY, Gao HL, Dahlstrom A, Huang L: Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells. Neuroreport; 2006 Nov 27;17(17):1807-11
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  • [Title] Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells.
  • The cellular localization of zinc transporter 7 protein in the mouse choroid plexus was examined in this study.
  • The results support the notion that zinc transporter 7 may participate in the transport of the cytoplasmic zinc into the Golgi apparatus, and may be involved in local packaging of zinc-binding proteins in the mouse choroid plexus.
  • [MeSH-major] Carrier Proteins / metabolism. Choroid Plexus / cytology. Epithelial Cells / ultrastructure. Golgi Apparatus / metabolism

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  • (PMID = 17164669.001).
  • [ISSN] 0959-4965
  • [Journal-full-title] Neuroreport
  • [ISO-abbreviation] Neuroreport
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / zinc-binding protein
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74. Kenney MC, Atilano SR, Boyer D, Chwa M, Chak G, Chinichian S, Coskun P, Wallace DC, Nesburn AB, Udar NS: Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients. Invest Ophthalmol Vis Sci; 2010 Aug;51(8):4289-97
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  • METHODS: Total DNA was isolated from retinas (AMD, n = 13; age-matched normal, n = 13), choroid (AMD, n = 3), and blood (AMD, n = 138; normal, n = 133).


75. Toivonen P, Kivelä T: Pigmented episcleral deposits after brachytherapy of uveal melanoma. Ophthalmology; 2006 May;113(5):865-73
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  • PARTICIPANTS: Two hundred eleven patients (108 males, 103 females; median age, 61 years; range, 14-88 years) who were treated with a single ruthenium and iodine plaque therapy (median dose to tumor base, 475 Gy and 392 Gy, respectively) for a choroidal and ciliary body melanoma.
  • Median tumor diameter and height were 12 mm and 5.5 mm, respectively.
  • The association of the deposits with tumor characteristics and survival was analyzed with logistic regression and Kaplan-Meier analysis, respectively.
  • The deposits increased in number until 7 years from irradiation, and decreased with increasing distance from tumor center.
  • Their association with plaque size and isotope rather than with tumor size suggests that radiation atrophy of retinal pigment epithelium and choroid in addition to tumor regression contributes to the formation of the deposits.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Atrophy. Choroid / pathology. Choroid / radiation effects. Female. Humans. Iodine Radioisotopes / adverse effects. Iodine Radioisotopes / therapeutic use. Macrophages / metabolism. Macrophages / pathology. Male. Middle Aged. Pigment Epithelium of Eye / pathology. Pigment Epithelium of Eye / radiation effects. Prospective Studies. Ruthenium Radioisotopes / adverse effects. Ruthenium Radioisotopes / therapeutic use. Survival Rate

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  • (PMID = 16530837.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Iodine Radioisotopes; 0 / Ruthenium Radioisotopes
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76. Castillo-Meléndez M, Yan E, Walker DW: Expression of erythropoietin and its receptor in the brain of late-gestation fetal sheep, and responses to asphyxia caused by umbilical cord occlusion. Dev Neurosci; 2005 Mar-Aug;27(2-4):220-7
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  • After 1 x UCO, EPO and EPO-R expressions were increased in astrocytes (periventricular and cortical WM, striatum, corpus callosum), choroid plexus epithelial cells, scattered neurons in cortical layers IV-VI, hippocampal CA1 neurons, and in the molecular and granule layers of the cerebellum.

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  • (PMID = 16046857.001).
  • [ISSN] 0378-5866
  • [Journal-full-title] Developmental neuroscience
  • [ISO-abbreviation] Dev. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Receptors, Erythropoietin; 11096-26-7 / Erythropoietin
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77. Borgwardt L, Højgaard L, Carstensen H, Laursen H, Nowak M, Thomsen C, Schmiegelow K: Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. J Clin Oncol; 2005 May 1;23(13):3030-7
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  • The FDG uptake in tumors was semiquantitatively calculated by a region-of-interest-based tumor hotspot/brain index.
  • The choroid plexus papilloma (n = 1) and the pilocytic astrocytomas (n = 3) had a mean index of 3.26 (n = 38; r = 0.57; P < .01).
  • Digitally performed PET/MRI coregistration increased information on tumor characterization in 90% of cases.
  • CONCLUSION FDG PET of the brain with MRI coregistration can be used to obtain a more specific diagnosis with respect to malignancy grading.
  • Improved PET/MRI imaging of the benign hypermetabolic tumors is needed to optimize clinical use.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Male. Prospective Studies. Regional Blood Flow. Sensitivity and Specificity

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  • (PMID = 15860860.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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78. Sinclair AJ, Walker EA, Burdon MA, van Beek AP, Kema IP, Hughes BA, Murray PI, Nightingale PG, Stewart PM, Rauz S, Tomlinson JW: Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation? J Clin Endocrinol Metab; 2010 Dec;95(12):5348-56
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  • OBJECTIVE: The aim was to characterize 11β-HSD1 in human cerebrospinal fluid (CSF) secretory [choroid plexus (CP)] and drainage [arachnoid granulation tissue (AGT)] structures, and to evaluate 11β-HSD1 activity after therapeutic weight loss in IIH.
  • [MeSH-minor] Adult. Biomarkers / cerebrospinal fluid. Biomarkers / metabolism. Choroid Plexus / pathology. Choroid Plexus / physiopathology. Chromatography, Liquid. Epithelial Cells / pathology. Female. Gas Chromatography-Mass Spectrometry. Humans. Mass Spectrometry. Obesity / blood. Obesity / cerebrospinal fluid. Obesity / complications. Obesity / urine. Polymerase Chain Reaction. RNA / genetics. RNA / isolation & purification. RNA, Messenger / genetics. Steroids / urine. Weight Loss

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  • (PMID = 20826586.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0601430; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Biomarkers; 0 / RNA, Messenger; 0 / Steroids; 63231-63-0 / RNA; EC 1.1.1.146 / 11-beta-Hydroxysteroid Dehydrogenase Type 1; WI4X0X7BPJ / Hydrocortisone
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79. Muniz A, Betts BS, Trevino AR, Buddavarapu K, Roman R, Ma JX, Tsin AT: Evidence for two retinoid cycles in the cone-dominated chicken eye. Biochemistry; 2009 Jul 28;48(29):6854-63
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  • First, we show that whole chicken retina in vitro, removed from the RPE/choroid and sclera, produces 11-cis retinoids upon light exposure, indicating the existence of RPE-independent isomerase (Isomerase II) activity in the retina.

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  • (PMID = 19492794.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / S06 GM008194; United States / NIGMS NIH HHS / GM / S06 GM008194-25S10076; United States / NIGMS NIH HHS / GM / GM08194
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Eye Proteins; 0 / Retinoids; 4G7DS2Q64Y / Progesterone; EC 2.3.- / Acyltransferases; EC 2.3.1.- / lecithin-retinol acyltransferase; O3C74ACM9V / Ethylmaleimide
  • [Other-IDs] NLM/ NIHMS129864; NLM/ PMC2733357
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80. Kamal MA, Jiang H, Hu Y, Keep RF, Smith DE: Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice. Am J Physiol Regul Integr Comp Physiol; 2009 Apr;296(4):R986-91
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  • With respect to endogenous carnosine levels, significant reductions were observed in Pept2 null compared with wild-type mice for choroid plexus (0.026 vs. 0.20 mmol/kg), olfactory bulb (1.12 vs. 1.79 mmol/kg), and spleen (0.019 vs. 0.029 mmol/kg).

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  • (PMID = 19225147.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / T32 GM007767; United States / NIGMS NIH HHS / GM / R01-GM-035498; United States / NINDS NIH HHS / NS / R01-NS-034709; United States / NIGMS NIH HHS / GM / T32-GM-007767; United States / NIGMS NIH HHS / GM / R01 GM035498
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Symporters; 0 / hydrogen-coupled oligopeptide transporter PepT2; 8HO6PVN24W / Carnosine
  • [Other-IDs] NLM/ PMC2698603
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81. Johnson PT, Brown MN, Pulliam BC, Anderson DH, Johnson LV: Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Invest Ophthalmol Vis Sci; 2005 Dec;46(12):4788-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Human donor eye tissue containing retina, RPE, and choroid was processed for confocal immunofluorescence microscopy, laser capture microdissection, and light and electron microscopy.

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  • (PMID = 16303980.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY11521; United States / NEI NIH HHS / EY / EY11527
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Nerve Tissue Proteins; 0 / beta-Crystallin A Chain
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82. Koyama S, Kimura T, Tokugawa Y, Koyama M, Murata Y, Shimizu T: Occurrence of fetal choroid plexus cysts in siblings: concerns regarding recurrence and chromosomal abnormality. J Obstet Gynaecol Res; 2005 Dec;31(6):562-4
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  • [Title] Occurrence of fetal choroid plexus cysts in siblings: concerns regarding recurrence and chromosomal abnormality.
  • Choroid plexus cysts (CPC) are a well-known ultrasound aneuploidy marker easily detectable at second-trimester ultrasound examination.
  • [MeSH-major] Brain Neoplasms / congenital. Central Nervous System Cysts / congenital. Choroid Plexus

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  • [CommentIn] J Obstet Gynaecol Res. 2006 Oct;32(5):529-30 [16984524.001]
  • (PMID = 16343260.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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83. Jasielska M, Semkova I, Shi X, Schmidt K, Karagiannis D, Kokkinou D, Mackiewicz J, Kociok N, Joussen AM: Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization. Invest Ophthalmol Vis Sci; 2010 Aug;51(8):3874-83
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  • [Title] Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization.
  • PURPOSE: Tumor necrosis factor alpha (TNF)-alpha contributes to inflammation-associated angiogenesis.
  • TNF-alpha expression in RPE/choroid was determined by Western blot analysis.
  • [MeSH-major] Choroid / metabolism. Choroidal Neovascularization / metabolism. Receptors, Tumor Necrosis Factor, Type I / physiology. Receptors, Tumor Necrosis Factor, Type II / physiology. Retinal Pigment Epithelium / metabolism. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 20335614.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Tumor Necrosis Factor, Type I; 0 / Receptors, Tumor Necrosis Factor, Type II; 0 / Tnfrsf1a protein, mouse; 0 / Tumor Necrosis Factor-alpha; EC 2.7.1.- / Bmx protein, mouse; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 8
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84. Nakayama H, Kitaichi K, Ito Y, Hashimoto K, Takagi K, Yokoi T, Takagi K, Ozaki N, Yamamoto T, Hasegawa T: The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats. Brain Res; 2007 Dec 12;1184:260-9
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  • Considering the earlier in vitro studies demonstrating that 1) OCT3 could transport dopamine (DA) and 2) the specific transport via OCT3 could be inhibited by METH, these results suggest that decreased OCT3 might decrease the efflux of METH and/or DA from brain, subsequently causing the development of behavioral sensitization.
  • Thus, in the present study, behavioral task related to DA and pharmacokinetic experiment were performed using rats treated with antisense against OCT3 (OCT3-AS) since no specific ligands for OCT3 are still available.
  • The continuous infusion of OCT3-AS into the third ventricle significantly decreased the expression of OCT3 in choroid plexus (CP) epithelial cells.
  • Both METH-induced hyperlocomotion and METH-induced extracellular DA levels in nucleus accumbens and prefrontal cortex were significantly increased in OCT3-AS-treated rats.
  • These results suggested that decreased OCT3 elevated the concentration of METH and/or DA in brain, subsequently enhancing dopaminergic neuronal transmission and increasing METH-induced hyperlocomotion.
  • In summary, OCT3 at the CP could regulate the effect of METH by controlling the levels of METH and/or DA in brain.

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  • (PMID = 17988657.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Central Nervous System Stimulants; 0 / Oligonucleotides, Antisense; 0 / Organic Anion Transporters, Sodium-Independent; 0 / organic anion transport protein 3; 44RAL3456C / Methamphetamine; VTD58H1Z2X / Dopamine
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85. Tian H, Lu Y, Sherwood AM, Hongqian D, Hong S: Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions. Invest Ophthalmol Vis Sci; 2009 Aug;50(8):3613-20
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  • [Title] Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions.
  • PURPOSE: To investigate the biosynthesis of resolvins E1 and D1 (RvE1 and RvD1) in choroid-retinal endothelial cells (CRECs) and leukocytes under inflammatory conditions and to define the mechanisms of anti-inflammatory actions of RvE1 and RvD1 in CRECs and leukocytes, cells crucial to posterior ocular inflammation.
  • RvE1 or RvD1 inhibited the expressions of vascular cell adhesion molecule-1, IL-8, macrophage inflammatory protein-1beta, regulated on activation normal T cell expressed and secreted, and tumor necrosis factor-alpha from CRECs or cocultures of CRECs and leukocytes.
  • [MeSH-minor] Animals. Blotting, Western. Cell Line. Cells, Cultured. Chemokine CCL4 / metabolism. Chemokine CCL5 / metabolism. Chemotaxis, Leukocyte. Choroid / blood supply. Coculture Techniques. Enzyme-Linked Immunosorbent Assay. Humans. Macaca mulatta. Protein Array Analysis. Retinal Vessels / cytology. Tandem Mass Spectrometry. Tumor Necrosis Factor-alpha / metabolism. Vascular Cell Adhesion Molecule-1 / metabolism

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  • (PMID = 19443724.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid; 0 / Chemokine CCL4; 0 / Chemokine CCL5; 0 / Tumor Necrosis Factor-alpha; 0 / Vascular Cell Adhesion Molecule-1; 0 / resolvin D1; 25167-62-8 / Docosahexaenoic Acids; AAN7QOV9EA / Eicosapentaenoic Acid
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86. Park KA, Kim HJ, Kim YD: Ectopic brain in the orbit with congenital adduction deficit and simultaneous abduction. Ophthal Plast Reconstr Surg; 2007 May-Jun;23(3):244-6
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  • Microscopic examination disclosed that the mass was brain tissue composed of arachnoid tissue, brain parenchyma, choroid plexus, and dura mater.
  • [MeSH-major] Brain. Choristoma / pathology. Enophthalmos / diagnosis. Ocular Motility Disorders / diagnosis. Oculomotor Muscles / abnormalities. Orbital Diseases / pathology
  • [MeSH-minor] Atrophy. Cysts / diagnosis. Female. Humans. Infant. Magnetic Resonance Imaging

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  • (PMID = 17519673.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Henderson RH, Cohen VM, Rath PP, Luthert P, Hungerford JL: Histopathologically proven mucinous cystadenocarcinoma metastatic to the choroid. Retin Cases Brief Rep; 2010;4(2):181-3
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  • [Title] Histopathologically proven mucinous cystadenocarcinoma metastatic to the choroid.
  • PURPOSE: To report the first case of conventional transcleral choroidal biopsy in the diagnosis of ovarian carcinoma metastatic to the choroid and to summarize the published cases of ovarian carcinoma metastatic to the choroid.
  • Transcleral choroidal biopsy allowed the diagnosis of metastatic mucinous cystadenocarcinoma of the ovary.
  • CONCLUSION: Ovarian carcinoma rarely metastases to the choroid and unlike breast carcinoma, concurrent central nervous system disease has not been reported.

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  • (PMID = 25390397.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Matsumoto H, Nakamura Y, Iida H, Ito K, Ohguro H: Comparative assessment of distribution of blackcurrant anthocyanins in rabbit and rat ocular tissues. Exp Eye Res; 2006 Aug;83(2):348-56
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  • Following i.v. administration in rabbits, four ACs were identified in the plasma and several ocular tissues including the aqueous humor, cornea, sclera, choroid, ciliary body, iris and retina.

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  • (PMID = 16635490.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthocyanins
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89. Nimura M, Udagawa J, Hatta T, Hashimoto R, Otani H: Spatial and temporal patterns of expression of melanocortin type 2 and 5 receptors in the fetal mouse tissues and organs. Anat Embryol (Berl); 2006 Mar;211(2):109-17
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  • At different temporal patterns, MC2R, but not MC5R, was detected in the choroid plexus, while MC5R, but not MC2R, was expressed in the liver and in the nasal epithelium, and both MC2R and MC5R were expressed in the dorsal root ganglion and the trigeminal ganglion.

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  • (PMID = 16463171.001).
  • [ISSN] 0340-2061
  • [Journal-full-title] Anatomy and embryology
  • [ISO-abbreviation] Anat. Embryol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptor, Melanocortin, Type 2; 0 / Receptors, Corticotropin; 0 / Receptors, Melanocortin; 0 / melanocortin 5 receptor; 9002-60-2 / Adrenocorticotropic Hormone
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90. Im E, Kazlauskas A: PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis. Expert Opin Ther Targets; 2007 Apr;11(4):443-51
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  • Similarly, pathologic angiogenesis of the retina or choroid underscores blinding diseases that afflict a substantial percentage of the world's population.

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  • (PMID = 17373875.001).
  • [ISSN] 1744-7631
  • [Journal-full-title] Expert opinion on therapeutic targets
  • [ISO-abbreviation] Expert Opin. Ther. Targets
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY018344; United States / NEI NIH HHS / EY / EY016385
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Phosphatidylinositol 4,5-Diphosphate
  • [Number-of-references] 73
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91. Siu FK, Sham MH, Chow BK: The prenatal expression of secretin receptor. Ann N Y Acad Sci; 2006 Jul;1070:561-5
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  • In this article, using mouse embryos and by in situ hybridization, secretin receptor transcripts were detected in several developing brain regions including the cerebellar primordium and choroid plexus.

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  • (PMID = 16888225.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Gastrointestinal Hormone; 0 / secretin receptor
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92. Marowsky A, Burgener J, Falck JR, Fritschy JM, Arand M: Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism. Neuroscience; 2009 Oct 6;163(2):646-61
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  • We find sEH immunoreactivity almost exclusively in astrocytes throughout the brain, except in the central amygdala, where neurons are also positive for sEH. mEH immunoreactivity is abundant in brain vascular cells (endothelial and smooth muscle cells) and in choroid plexus epithelial cells.
  • [MeSH-minor] Animals. Astrocytes / enzymology. Astrocytes / metabolism. Blood Vessels / enzymology. Blood Vessels / metabolism. Cells, Cultured. Choroid Plexus / enzymology. Choroid Plexus / metabolism. Epithelial Cells / enzymology. Epithelial Cells / metabolism. Female. Immunohistochemistry. Male. Mass Spectrometry. Mice. Mice, Inbred C57BL. Mice, Knockout. Myocytes, Smooth Muscle / enzymology. Myocytes, Smooth Muscle / metabolism. Neurons / enzymology. Neurons / metabolism. Sex Characteristics

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  • (PMID = 19540314.001).
  • [ISSN] 1873-7544
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eicosanoids; 0 / Epoxy Compounds; EC 3.3.2.- / Epoxide Hydrolases
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93. Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR: Cavitary choroidal melanoma. Can J Ophthalmol; 2005 Oct;40(5):619-22
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  • The results of ultrasonography, magnetic resonance imaging, computed tomography, and immunohistochemical studies are presented for a 38-year-old woman who developed an amelanotic tumor in the posterior choroid.
  • Enucleation was performed and histopathologic examination showed a choroidal melanoma of spindle cell type, with intratumoral cavitations lined by flattened tumor cells.
  • Uveal melanoma should be included in the differential diagnosis of choroidal cavitary lesions.

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  • (PMID = 16391628.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Vimentin
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94. Lee J, Willer JR, Willer GB, Smith K, Gregg RG, Gross JM: Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye. Dev Biol; 2008 Jul 1;319(1):10-22
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  • Colobomas result from defects in optic stalk morphogenesis whereby the optic stalk extends into the retina and impedes the lateral edges of the choroid fissure from meeting and fusing.

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  • (PMID = 18479681.001).
  • [ISSN] 1095-564X
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P40 RR012546; United States / NCRR NIH HHS / RR / R01 RR020357; United States / NCRR NIH HHS / RR / RR020357-04; United States / NCRR NIH HHS / RR / R01 RR020357-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Membrane Proteins; 0 / Receptors, Cell Surface; 0 / Zebrafish Proteins; 0 / patched receptors; 0 / ptc2 protein, zebrafish
  • [Other-IDs] NLM/ NIHMS56256; NLM/ PMC2529176
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95. Yoshida Y, Ikematsu S, Muramatsu H, Sakakima H, Mizuma N, Matsuda F, Sonoda K, Umehara F, Ohkubo R, Matsuura E, Goto M, Osame M, Muramatsu T: Expression of the heparin-binding growth factor midkine in the cerebrospinal fluid of patients with neurological disorders. Intern Med; 2008;47(2):83-9
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  • MK was expressed in choroid plexus of normal brain and released there.
  • [MeSH-major] Cerebral Infarction / metabolism. Cerebrospinal Fluid / chemistry. Choroid Plexus / metabolism. Cytokines / cerebrospinal fluid. Cytokines / metabolism. Meningitis / metabolism

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  • (PMID = 18195496.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cytokines; 137497-38-2 / midkine
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96. Senanayake Pd, Drazba J, Shadrach K, Milsted A, Rungger-Brandle E, Nishiyama K, Miura S, Karnik S, Sears JE, Hollyfield JG: Angiotensin II and its receptor subtypes in the human retina. Invest Ophthalmol Vis Sci; 2007 Jul;48(7):3301-11
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  • The retina had the highest levels of Ang II receptors that were significantly higher than the optic nerve, retinal pigment epithelium-choroid complex, and ciliary body-iris complex (P < 0.05).

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  • (PMID = 17591902.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY013752; United States / NEI NIH HHS / EY / EY015638
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptide Fragments; 0 / Receptor, Angiotensin, Type 1; 0 / Receptor, Angiotensin, Type 2; 0 / angiotensin I (1-7); 11128-99-7 / Angiotensin II; 9041-90-1 / Angiotensin I; EC 3.4.15.1 / Peptidyl-Dipeptidase A; EC 3.4.17.- / angiotensin converting enzyme 2
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97. Biroccio A, Del Boccio P, Panella M, Bernardini S, Di Ilio C, Gambi D, Stanzione P, Sacchetta P, Bernardi G, Martorana A, Federici G, Stefani A, Urbani A: Differential post-translational modifications of transthyretin in Alzheimer's disease: a study of the cerebral spinal fluid. Proteomics; 2006 Apr;6(7):2305-13
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  • TTR in the cerebral spinal fluid (CSF) is primarily synthesized by the choroid plexus.

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  • (PMID = 16552785.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Prealbumin; 0 / Sulfhydryl Compounds
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98. Xu W, Ye P, Li Z, Shi J, Wang W, Yao K: Endostar, a recently introduced recombinant human endostatin, inhibits proliferation and migration through regulating growth factors, adhesion factors and inflammatory mediators in choroid-retinal endothelial cells. Mol Biol (Mosk); 2010 Jul-Aug;44(4):664-70
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  • [Title] Endostar, a recently introduced recombinant human endostatin, inhibits proliferation and migration through regulating growth factors, adhesion factors and inflammatory mediators in choroid-retinal endothelial cells.
  • In this study, we demonstrate that Endostar inhibits both the proliferation of the choroid-retinal endothelial cells through limiting the progression of the cell cycle and their migration.
  • Endostar also reduces the expression of the inflammatory mediator tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinases (MMPs) and vascular cell adhesion molecule-1 (VCAM-1).
  • [MeSH-major] Angiogenesis Inhibitors / pharmacology. Cell Movement / drug effects. Cell Proliferation / drug effects. Choroid / metabolism. Endostatins / pharmacology. Endothelial Cells / metabolism. Inflammation Mediators / metabolism. Intercellular Signaling Peptides and Proteins / biosynthesis. Recombinant Proteins / pharmacology. Retina / metabolism. Vascular Cell Adhesion Molecule-1 / biosynthesis

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  • (PMID = 20873226.001).
  • [ISSN] 0026-8984
  • [Journal-full-title] Molekuliarnaia biologiia
  • [ISO-abbreviation] Mol. Biol. (Mosk.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Endostatins; 0 / Inflammation Mediators; 0 / Intercellular Signaling Peptides and Proteins; 0 / Recombinant Proteins; 0 / Vascular Cell Adhesion Molecule-1; 0 / endostar protein
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99. Hahn P, Ying GS, Beard J, Dunaief JL: Iron levels in human retina: sex difference and increase with age. Neuroreport; 2006 Nov 27;17(17):1803-6
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  • We used atomic absorption spectrophotometry to assess quantitatively iron levels within the eye structures, retina and retinal pigment epithelium/choroid of normal human eyes of various ages and of both sexes.

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  • (PMID = 17164668.001).
  • [ISSN] 0959-4965
  • [Journal-full-title] Neuroreport
  • [ISO-abbreviation] Neuroreport
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY015240
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] E1UOL152H7 / Iron
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100. Tachikawa M, Fujinawa J, Takahashi M, Kasai Y, Fukaya M, Sakai K, Yamazaki M, Tomi M, Watanabe M, Sakimura K, Terasaki T, Hosoya K: Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. J Neurochem; 2008 Nov;107(3):768-78
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  • There was wide and distinct cerebral expression of CRT and localization of CRT on the brush-border membrane of choroid plexus epithelial cells.
  • The characteristics of GAA uptake by isolated choroid plexus and an immortalized rat choroid plexus epithelial cell line (TR-CSFB cells) used as an in vitro model of BCSFB are partially consistent with those of CRT.
  • These results suggest that CRT plays a role in the cerebral distribution of GAA and GAA uptake by the choroid plexus.
  • [MeSH-minor] Animals. Biological Transport. Cell Line. Cerebrospinal Fluid / chemistry. Cerebrospinal Fluid / metabolism. Choroid Plexus / metabolism. Convulsants / metabolism. Epithelial Cells / metabolism. Epithelial Cells / ultrastructure. Humans. Immunoblotting. Immunohistochemistry. In Situ Hybridization. Male. Mice. Microvilli / metabolism. Rats. Rats, Wistar. Reverse Transcriptase Polymerase Chain Reaction. Xenopus laevis

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  • (PMID = 18761709.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Convulsants; 0 / Membrane Transport Proteins; 0 / creatine transporter; GO52O1A04E / glycocyamine; TE7660XO1C / Glycine
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