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1. Acs G, Zhang PJ, McGrath CM, Acs P, McBroom J, Mohyeldin A, Liu S, Lu H, Verma A: Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. Am J Pathol; 2003 Jun;162(6):1789-806
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  • [Title] Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression.
  • Tissue hypoxia is a characteristic property of cervical cancers that makes tumors resistant to chemo- and radiation therapy.
  • In addition to human papillomavirus infection, increased bcl-2 expression and decreased apoptosis are thought to play a role in the progression of cervical neoplasia.
  • Using reverse transcriptase-polymerase chain reaction and Western blotting we showed that HeLa and SiHa cervical carcinoma cells and human cervical carcinomas express EpoR, and that hypoxia enhances EpoR expression.
  • Exogenous Epo stimulated tyrosine phosphorylation and inhibited the cytotoxic effect of cisplatin in HeLa cervical carcinoma cells.
  • Using immunohistochemistry, we examined the expression of Epo, EpoR, p16, hypoxia-inducible factor (HIF)-1alpha, and bcl-2 in benign and dysplastic cervical squamous epithelia and invasive squamous cell carcinomas (ISCCs).
  • EpoR expression in benign epithelia was confined to the basal cell layers, whereas in dysplasias it increasingly appeared in more superficial cell layers and showed a significant correlation with severity of dysplasia.
  • Expression of Epo and HIF-1alpha was increased in dysplasias compared to benign epithelia.
  • Significant correlation was found between expression of EpoR, and p16 and bcl-2 in benign and dysplastic squamous epithelia.
  • Our results suggest that increased expression of Epo and EpoR may play a significant role in cervical carcinogenesis and tumor progression.
  • Hypoxia-inducible Epo signaling may play a significant role in the aggressive behavior and treatment resistance of hypoxic cervical cancers.

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • MedlinePlus Health Information. consumer health - Cervical Cancer.
  • International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .
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  • (PMID = 12759237.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS037814; United States / NINDS NIH HHS / NS / NS37814
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Messenger; 0 / Receptors, Erythropoietin; 0 / Recombinant Proteins; 0 / Transcription Factors; 11096-26-7 / Erythropoietin
  • [Other-IDs] NLM/ PMC1868129
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2. Smaga A, Paszkowski T, Wo┼║niak S, Walczak R: [Analysis of physiologic and abnormal pictures of uterine cervix by means of infrared thermography]. Ginekol Pol; 2003 Sep;74(9):847-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of physiologic and abnormal pictures of uterine cervix by means of infrared thermography].
  • RATIONALE FOR THE STUDY: Diagnosis of the uterine cervix lesions remains a key element of the women's health care especially in the context of the cervical carcinoma prophylaxis.
  • The infrared mapping constitutes a new generation biophysical diagnostic method of potential application in medicine.
  • OBJECTIVE: The study was planned to analyze uterine cervix thermograms in both physiology and pathology of this organ.
  • In order to establish a physiologic standard, 14 thermograms of the normal cervix were analyzed in detail.
  • Furthermore, thermograms of such cervical lesions as endocervical polyp (3 patients), erosion (PAP II) (11 cases), CIN I-III (9 patients) and invasive cancer (6 patients) were studied.
  • The diagnosis was based on clinical, cytologic and colposcopic criteria as well as on the pathology report.
  • RESULTS: Comparisons between the studied groups revealed significant differences between invasive cervical cancer and benign lesions or healthy cervix.
  • The difference in mean whole portion temperature between the normal cervix and invasive planoepithelial cancer amounted to 1.4 degrees C while in comparison to other lesions it did not exceed 0.5 degree C.
  • Statistical analysis of the averaged profiles of cervical temperatures has also shown significant differences between invasive cancer and the remaining groups--by 1.5 degrees C in average.
  • The established thermographic mapping patterns of the normal cervix may form a basis for the future evaluation of the diagnostic application of computer thermography in gynecology.
  • 2. Statistically significant differences were found in thermographic profiles of the portion between the normal cervix and such cervical lesions as endocervical polyp, erosion (PAP II), CIN and invasive cancer.
  • 3. Invasive cervical cancer reveals thermographic pattern of relatively high specificity within the analyzed cervical lesions.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / diagnosis. Cervix Uteri / pathology. Infrared Rays. Thermography / standards. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Body Temperature. Female. Humans. Middle Aged. Neoplasm Invasiveness. Predictive Value of Tests. Risk Factors. Sensitivity and Specificity. Uterine Cervical Diseases / diagnosis






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