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51. Faik A, Mahfoud Filali S, Lazrak N, El Hassani S, Hajjaj-Hassouni N: Spinal cord compression due to vertebral osteochondroma: report of two cases. Joint Bone Spine; 2005 Mar;72(2):177-9
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  • Osteochondroma, or exostosis, is the most common of all benign bone tumors.

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  • (PMID = 15797501.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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52. Xu J, Xu CR, Wu H, Pan HL, Tian J: Osteochondroma in the lumbar intraspinal canal causing nerve root compression. Orthopedics; 2009 Feb;32(2):133
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  • Osteochondromas, which are benign bone tumors that usually develop on long bones, tubular bones, are rarely found in the spine.
  • Considering differential diagnosis, lumbar facet synovial cysts must be excluded as they can also cause myeloradiculopathy with the similar mechanism.
  • The tumor, approximately 6x7x11 mm, was identified after laminectomy of the L5 laminae.
  • Postoperative histopathologic examination confirmed our hypothesis of benign osteochondroma.
  • Computed tomography and MRI are helpful for the preoperatively precise indication of tumor extent and its relationships with the adjacent.

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  • (PMID = 19301786.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Kim J, Kumar R, Raymond AK, Ayala AG: Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature. Skeletal Radiol; 2010 Jun;39(6):583-7
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  • [Title] Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature.
  • Chondroblastoma is a benign bone tumor that typically arises in the epiphysis of a long bone.
  • We describe such a case of chondroblastoma arising in the iliac bone.
  • The radiographs and CT revealed an expansile lytic lesion in the right iliac bone.
  • The histopathology revealed the lesion to be a chondroblastoma with secondary features of aneurysmal bone cyst.
  • An en bloc surgical resection of the tumor was performed.
  • [MeSH-major] Bone Cysts, Aneurysmal / complications. Bone Cysts, Aneurysmal / diagnostic imaging. Bone Neoplasms / complications. Bone Neoplasms / diagnostic imaging. Chondroblastoma / complications. Chondroblastoma / diagnostic imaging. Ilium / diagnostic imaging. Tomography, X-Ray Computed

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  • [Cites] Skeletal Radiol. 2006 Jan;35(1):49-52 [16010594.001]
  • [Cites] Clin Orthop Relat Res. 1973 Sep;(95):300-12 [4585180.001]
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  • (PMID = 19936740.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 12
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5
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4. Niethard M, Rogalski M, Deja M, Zacher J: [Partial physeal growth arrest with increasing genu varum deformity caused by a cortical enchondroma--a case report]. Z Orthop Unfall; 2008 Nov-Dec;146(6):725-9
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  • The X-ray and MRI investigations have shown a benign lesion like osteofibroma of the mediodistal femur with an affection of the medial physis.
  • 1) resection of the benign lesion and arthroscopically assisted resection of the bony bar with fat-patch interposition;.
  • CONCLUSION: In cases of rare partial bridging of the physis induced by a benign bone tumour one can achieve early correction of axial deviation during growth with resection, interposition of a fat patch and temporary hemiepiphyseodesis.
  • [MeSH-major] Arthroscopy. Bone Malalignment / surgery. Bone Plates. Cartilage, Articular / surgery. Chondroma / surgery. Femur / surgery. Growth Plate / surgery. Knee Joint / surgery

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  • (PMID = 19085720.001).
  • [ISSN] 1864-6697
  • [Journal-full-title] Zeitschrift für Orthopädie und Unfallchirurgie
  • [ISO-abbreviation] Z Orthop Unfall
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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55. Figl M, Leixnering M: Retrospective review of outcome after surgical treatment of enchondromas in the hand. Arch Orthop Trauma Surg; 2009 Jun;129(6):729-34
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  • BACKGROUND: Tumours of the skeleton of the hand are rare.
  • While the majority of bone tumours are benign (89.4%), a small number show signs of malignancy (4.4%).
  • Among the benign bone tumours of the skeleton of the hand, enchondromas are the most common, at 35-65%.
  • The most common site of an enchondroma was the proximal phalanx in 17 cases, followed by the metacarpal bone in 8 cases and the middle phalanx in 5 cases.
  • For accurate diagnosis, conventional X-ray examination and if necessary, a contrast medium MRI should be performed.
  • Depending on its spread, the defect in the extirpation cavity should be filled with autogenous spongy bone.
  • [MeSH-major] Bone Neoplasms / surgery. Chondroma / surgery. Hand / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Transplantation. Female. Fingers / pathology. Fingers / surgery. Fractures, Spontaneous / diagnosis. Fractures, Spontaneous / pathology. Fractures, Spontaneous / surgery. Hand Injuries / diagnosis. Hand Injuries / pathology. Hand Injuries / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18726106.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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56. Cai Y, Mohseny AB, Karperien M, Hogendoorn PC, Zhou G, Cleton-Jansen AM: Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. J Pathol; 2010 Jan;220(1):24-33
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  • Osteosarcoma is the most common malignant bone tumour, with a peak incidence in children and young adolescents, suggesting a role of rapid bone growth in its pathogenesis.
  • Therefore, in this study, we examined nuclear beta-catenin expression in 52 human osteosarcoma biopsies, 15 osteoblastomas (benign bone tumours), and four human osteosarcoma cell lines by immunohistochemistry.
  • Stimulation of the Wnt/beta-catenin pathway by GIN significantly reduced cell proliferation in the cell lines MG-63 and U-2-OS and enhanced differentiation in the cell lines HOS and SJSA-1, as shown by an increase in alkaline phosphatase (ALP) activity and mineralization.
  • [MeSH-major] Bone Neoplasms / physiopathology. Osteosarcoma / physiopathology. Wnt Proteins / physiology. beta Catenin / metabolism
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Cell Proliferation. Glycogen Synthase Kinase 3 / antagonists & inhibitors. Glycogen Synthase Kinase 3 / physiology. Hedgehog Proteins / physiology. Humans. Intercellular Signaling Peptides and Proteins / metabolism. Mice. Neoplasm Proteins / metabolism. Neoplasm Proteins / physiology. Osteoblasts / pathology. Recombinant Proteins / pharmacology. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / drug effects. Signal Transduction / physiology. Tumor Cells, Cultured. Wnt3 Protein

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  • [CommentIn] J Pathol. 2010 Jan;220(1):1-4 [19890890.001]
  • (PMID = 19882675.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DKK1 protein, human; 0 / Hedgehog Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Neoplasm Proteins; 0 / Recombinant Proteins; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / beta Catenin; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3
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57. Rodríguez Paramás A, Lendoiro Otero C, González García JA, Souviron Encabo R, Scola Yurrita B: [Temporal bone chondroblastoma. A clinical case and literature review]. Acta Otorrinolaringol Esp; 2006 Aug-Sep;57(7):336-8
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  • [Title] [Temporal bone chondroblastoma. A clinical case and literature review].
  • [Transliterated title] Condroblastoma de hueso temporal. Caso clínico y revisión de la literatura.
  • After radiologic diagnosis, intraoperatory biopsy and surgical removal, the anatomopathological result confirmed the histology of chondroblatoma, with a satisfactory postoperative evolution.
  • The chondroblastoma is a benign bone tumor typically located in the epiphysis of long bones and the temporal bone is an excepcional location as we have verified through a literature review.
  • [MeSH-major] Chondroblastoma. Skull Neoplasms. Temporal Bone

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  • (PMID = 17036998.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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58. Ramboaniaina S, Hoang DV, Berger M: [Aneurysmal carpal scaphoid cyst. A case report]. Chir Main; 2009 Feb;28(1):46-9
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  • Aneurysmal bone cyst is a rare, benign bone tumor and its location in the carpal scaphoid has never been described in the literature.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Scaphoid Bone / radiography

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  • (PMID = 19095484.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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59. Schnirring-Judge M, Visser J: Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case. J Foot Ankle Surg; 2009 Jul-Aug;48(4):495-505
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  • [Title] Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case.
  • Osteochondroma, which is also known as exostosis, is the most common benign bone tumor.
  • In this review, we describe the clinical and diagnostic imaging characteristics of benign bone tumors and, in particular, the osteochondroma and its surgical management.
  • [MeSH-major] Bone Neoplasms / surgery. Hallux / surgery. Osteochondroma / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasms, Post-Traumatic / pathology. Young Adult

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  • (PMID = 19577730.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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60. Aldea S, Bonneville F, Poirier J, Chiras J, George B, Carpentier A: Acute spinal cord compression in hereditary multiple exostoses. Acta Neurochir (Wien); 2006 Feb;148(2):195-8; discussion 198
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  • Osteocartilaginous exostoses are benign bone tumors frequently found in the metaphysis of long bones but rarely in the spine.


61. Matysiakiewicz J, Tomasik P, Miszczyk L, Spindel J, Widuchowski J, Koczy B, Chrobok A, Mrozek T: Manifestations, diagnosis and surgical treatment of enchondroma--own experience. Ortop Traumatol Rehabil; 2010 Mar-Apr;12(2):155-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Manifestations, diagnosis and surgical treatment of enchondroma--own experience.
  • BACKGROUND: An enchondroma is a rather common benign tumour of bone that originates from cartilage.The course is usually benign but they have a tendency to recur and are sometimes invasive, especially when developing in long bones.
  • RESULTS: The tumours were mostly located in phalanges of the fingers--55 cases (37%), and metacarpal bones--21 cases (14%).
  • A total of 170 surgical procedures were performed, mostly (120 procedures) tumour resections with bone graft implantation.
  • CONCLUSION: Total resection of the enchondroma combined with spongy bone grafting is the main treatment of chondroma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Chondroma / diagnosis. Chondroma / surgery

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  • (PMID = 20453254.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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62. Katthagen BD, Prub A: [Bone allografting]. Orthopade; 2008 Aug;37(8):764-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Bone allografting].
  • [Transliterated title] Transplantation allogenen Knochens.
  • Bone allografts facilitate bone reconstruction in orthopedic surgery.
  • After implantation, bone allografts become necrotic but are incorporated and remodeled in the recipient bone with good regenerative capacity.
  • We use bone allografts in about 3% of all elective orthopedic operations in our hospital.
  • We use bone allografts regularly in acetabuloplasty in cases of severe residual hip dysplasia.
  • Bone allografts are most often used in revision total joint arthroplasty.
  • In cases of reconstruction of defects in benign bone tumors and tumor-like lesions, bone allografts are often suitable.
  • In fibrous dysplasia, corticocancellous bone allografts are even the treatment of choice.
  • [MeSH-major] Bone Transplantation / methods. Orthopedic Procedures
  • [MeSH-minor] Acetabulum / surgery. Adult. Arthroplasty, Replacement. Bone Banks. Bone Neoplasms / surgery. Bone Regeneration. Bone Remodeling / physiology. Child. Disinfection. Follow-Up Studies. Hip Dislocation, Congenital / surgery. Humans. Prosthesis Failure. Reoperation. Transplantation, Homologous

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  • (PMID = 18584151.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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63. Abou-Elhamd KE: Frontal sinus cementifying ossifying fibroma. Saudi Med J; 2005 Mar;26(3):470-2
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  • Cementifying ossifying fibroma is a fibro-osseous lesion which produces cementum.
  • Cementifying ossifying fibroma is a mesodermal, non-odontogenic tumor of ectopic multipotential periodontal membrane blast cells.
  • Although, it is a benign bone tumor, it has an aggressive destructive behavior in patients under 20 years of age with high tendency for recurrence.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fibroma, Ossifying / diagnosis. Frontal Sinus

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  • (PMID = 15806222.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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64. Gebert C, Brinkschmidt C, Bielack S, Bernhardt T, Jürgens H, Böcker W, Winkelmann W, Bürger H, Gosheger G: The potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions. Int J Surg Pathol; 2006 Jul;14(3):187-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions.
  • Matrix-producing bone lesions consist of a wide variety of benign and malignant conditions.
  • With respect to morphology, an overlap exists between benign and malignant bone tumors that causes difficulties in the final determination of the tumor.
  • This study was conducted to show the potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions.
  • Thirty benign bone tumors were evaluated by conventional comparative genomic hybridization.
  • In contrast benign tumors or tumor-like lesions did not reveal any chromosomal alterations.
  • Comparative genomic hybridization is a useful adjunct in the complicated differential diagnostic algorithms of matrix-producing bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chromosome Aberrations. DNA, Neoplasm / genetics. Molecular Diagnostic Techniques / methods. Osteosarcoma / diagnosis

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  • (PMID = 16959697.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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65. Fraquet N, Faizon G, Rosset P, Phillipeau J-, Waast D, Gouin F: Long bones giant cells tumors: treatment by curretage and cavity filling cementation. Orthop Traumatol Surg Res; 2009 Oct;95(6):402-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long bones giant cells tumors: treatment by curretage and cavity filling cementation.
  • OBJECTIVE: Giant cell tumors (GCT) of bone are benign tumors with local aggressiveness that most of the time occur around the metaphyseal area of long bones, often in contact with the articular cartilage.
  • Twenty-six of these tumors were present around the knee: 14 at the distal femur and 12 at the proximal tibia.
  • Preoperative radiological evaluation with standard X-rays showed that the tumor measured a mean 71x45mm, for a mean volume of 78cm(3).
  • Two cases of minor osteoarthritis progression were noted (one less than 50% and a simple densification of subchondral bone), requiring no specific treatment.
  • Diagnosis of recurrence can be made earlier because of the thin scalable border at the bone-cement interface.
  • [MeSH-major] Bone Cements / therapeutic use. Bone Neoplasms / surgery. Femur / surgery. Giant Cell Tumor of Bone / surgery. Orthopedic Procedures / methods. Tibia / surgery

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19767256.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Cements
  • [General-notes] NLM/ Original DateCompleted: 20100201
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66. Kim WJ, Kim KJ, Lee SK, Choy WS: Solitary pelvic osteochondroma causing L5 nerve root compression. Orthopedics; 2009 Dec;32(12):922
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor, accounting for more than one-third of all benign bone tumors.
  • Thus, surgical excision is not routinely recommended unless the tumor causes clinical symptoms or cosmetic distress.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / surgery. Decompression, Surgical / methods. Osteochondroma / complications. Osteochondroma / surgery. Pelvic Bones / radiography. Pelvic Bones / surgery. Radiculopathy / etiology. Radiculopathy / surgery

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  • [Copyright] Copyright 2009, SLACK Incorporated.
  • (PMID = 19968229.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Ozyurek S, Rodop O, Kose O, Cilli F, Mahirogullari M: Aneurysmal bone cyst of the fifth metacarpal. Orthopedics; 2009 Aug;32(8)
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  • [Title] Aneurysmal bone cyst of the fifth metacarpal.
  • Aneurysmal bone cyst is a rare, rapidly growing, and destructive benign bone tumor that even more rarely involves the bones of the hand.
  • Various treatment options for aneurysmal bone cyst have been reported in the literature, but controversy exists regarding optimal treatment.
  • Physical and radiographic examination of the hand was consistent with aneurysmal bone cyst.
  • After biopsy, pathologic examination confirmed the diagnosis of aneurysmal bone cyst.
  • En-block resection of the tumor and autologous bicortical strut graft fixation with Kirschner wires was performed.
  • Radiographic examination demonstrated the osseous integration of the graft with no signs of recurrence.
  • [MeSH-major] Bone Cysts, Aneurysmal / radiography. Bone Cysts, Aneurysmal / surgery. Bone Transplantation. Metacarpal Bones / radiography. Metacarpal Bones / surgery. Osteotomy

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  • (PMID = 19708623.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Gibbs CP, Lewis VO, Peabody T: Beyond bone grafting: techniques in the surgical management of benign bone tumors. Instr Course Lect; 2005;54:497-503
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  • [Title] Beyond bone grafting: techniques in the surgical management of benign bone tumors.
  • The traditional surgical treatment of benign bone tumors has been curettage and autologous bone graft or marginal resection of expendable bones.
  • Recently, however, surgeons have been evaluating the results of treatments using limited surgical approaches, including percutaneous treatments, alternatives to autograft bone, and thermal or cytotoxic adjuvant therapies.
  • This process has been facilitated by the availability of multiple bone grafting materials and substitutes, the use of cross-sectional imaging, and technology such as that used with radiofrequency ablation.
  • Techniques using these therapies in two benign bone tumor models are described.
  • The use of percutaneous radiofrequency ablation, now used for both benign and malignant disease, is reviewed as a surgical alternative for osteoid osteoma.
  • The role of adjuvant therapies such as liquid nitrogen and phenol, as well as the indications for resection, are described in the management of giant cell tumors of bone.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Giant Cell Tumor of Bone / surgery. Osteoma, Osteoid / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Bone Transplantation / methods. Humans. Prosthesis Implantation / methods

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  • (PMID = 15948474.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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69. Tsuchiya H, Morsy AF, Matsubara H, Watanabe K, Abdel-Wanis ME, Tomita K: Treatment of benign bone tumours using external fixation. J Bone Joint Surg Br; 2007 Aug;89(8):1077-83
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  • [Title] Treatment of benign bone tumours using external fixation.
  • We present a retrospective study of patients suffering from a variety of benign tumours in whom external fixators were used to treat deformity and limb-length discrepancy, and for the reconstruction of bone defects.
  • The diagnosis was Ollier's disease in 12 limbs, fibrous dysplasia in 11, osteochondroma in eight, giant cell tumour in five, osteofibrous dysplasia in five and non-ossifying fibroma in two.
  • [MeSH-major] Bone Neoplasms / surgery. External Fixators. Fracture Fixation / methods. Neoplasms, Connective Tissue / surgery. Osteochondrodysplasias / surgery. Osteochondroma / surgery

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  • (PMID = 17785749.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Reize F, Buess E: Humeral osteochondroma causing a subscapularis tear: a rare source of shoulder dysfunction. Arch Orthop Trauma Surg; 2007 Jan;127(1):67-70
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  • The proximal humerus is a well-known site of predilection for the solitary osteochondroma-the most common benign bone tumor.
  • The patient was successfully treated by open resection of the tumor and reattachment of the tendon with suture anchors.
  • [MeSH-major] Bone Neoplasms / complications. Humerus. Osteochondroma / complications. Rotator Cuff / injuries

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  • (PMID = 16927096.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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71. Goessmann H, Zorger N, Schreyer AG: [Aneurysmic bone cyst of the head of the mandible: a rare site of a benign bone tumor]. Rofo; 2009 Sep;181(9):902-4
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  • [Title] [Aneurysmic bone cyst of the head of the mandible: a rare site of a benign bone tumor].
  • [Transliterated title] Aneurysmatische Knochenzyste des Mandibulaköpfchens: eine seltene Lokalisation des benignen Knochentumors.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Magnetic Resonance Imaging. Mandibular Diseases / diagnosis. Sternoclavicular Joint. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Biopsy. Bone Plates. Curettage. Diagnosis, Differential. Female. Humans. Mandibular Condyle / pathology. Mandibular Condyle / surgery. Recurrence. Reoperation

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  • (PMID = 19582659.001).
  • [ISSN] 1438-9010
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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72. Montañez-Heredia E, Serrano-Montilla J, Merino-Ruiz ML, Amores-Ramírez F, Villalobos-Martín J: Osteoid osteoma: CT-guided radiofrequency ablation. Acta Orthop Belg; 2009 Feb;75(1):75-80
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  • Osteoid osteoma is a benign bone tumour; its main symptom is pain, which is sometimes resistant to analgesic or anti-inflammatory medication.
  • [MeSH-major] Bone Neoplasms / surgery. Osteoma, Osteoid / surgery

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  • (PMID = 19358403.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Belgium
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73. Wicart P, Seringe R: [Protective limp]. Arch Pediatr; 2008 Mar;15(3):340-8
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  • The diagnosis of acute transient synovitis (irritable hip) should only be made after excluding other conditions including benign bone tumours (such as ostioid osteoma), malignant tumours, inflammatory monoarthritis, primary osteochondritis of the hip, trauma with or without fracture, apophysitis, leukemia, etc.
  • The diagnosis of acute transient synovitis should be questioned if the condition persists for more than seven days.
  • After the age of nine years, the diagnosis that is important not to miss is proximal femoral epiphysiolysis, because this condition can have serious implications for the future function of the hip.
  • Finally, a psychogenic aetiology, tendinitis, or sprain should not be considered in children, and they risk delaying the diagnosis of a potentially serious condition.

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  • (PMID = 18314314.001).
  • [ISSN] 0929-693X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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74. van de Luijtgaarden AC, Veth RP, Slootweg PJ, Wijers-Koster PM, Schultze Kool LJ, Bovee JV, van der Graaf WT: Metastatic potential of an aneurysmal bone cyst. Virchows Arch; 2009 Nov;455(5):455-9
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  • [Title] Metastatic potential of an aneurysmal bone cyst.
  • Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa.
  • Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient.
  • Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor.
  • [MeSH-major] Bone Cysts, Aneurysmal / pathology. Bone Neoplasms / pathology. Neoplasms, Second Primary / pathology. Osteosarcoma / pathology. Proto-Oncogene Proteins / genetics. Ubiquitin Thiolesterase / genetics

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  • [Cites] Genes Chromosomes Cancer. 2000 Jun;28(2):233-4 [10825009.001]
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  • (PMID = 19838726.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Proto-Oncogene Proteins; 2S9ZZM9Q9V / Bevacizumab; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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75. Ben hadj Hamida F, Jlaiel R, Ben Rayana N, Mahjoub H, Mellouli T, Ghorbel M, Krifa F: [Craniofacial fibrous dysplasia: a case report]. J Fr Ophtalmol; 2005 Oct;28(8):e6
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  • Fibrous dysplasia is classified among benign bone tumors.
  • It is a bone development anomaly characterized by hamartoma proliferation of fibrous tissue within the medullary bone, with secondary bony metaplasia, producing immature, newly formed and weakly calcified bone, without maturation of the osteoblast.
  • Its diagnosis is not always straightforward because the functional symptomology is often absent or not specific.
  • Medical imagery is necessary and in difficult cases a bone biopsy.
  • [MeSH-major] Facial Bones. Fibrous Dysplasia, Polyostotic / diagnosis. Skull

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  • (PMID = 16249758.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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76. Finstein JL, Hosalkar HS, Ogilvie CM, Lackman RD: Case reports: an unusual complication of radiofrequency ablation treatment of osteoid osteoma. Clin Orthop Relat Res; 2006 Jul;448:248-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor traditionally treated nonoperatively or by operative excision.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / adverse effects. Osteoma, Osteoid / surgery. Skin / pathology. Skin Diseases / etiology. Tibia

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  • [CommentIn] Clin Orthop Relat Res. 2006 Oct;451:290-1; author reply 291-2 [16906101.001]
  • [CommentIn] Clin Orthop Relat Res. 2007 Jul;460:285; author reply 285-6 [17534193.001]
  • (PMID = 16826123.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Heck RK, Pope WD, Ahn JI, Smith RA, Webber BL: Histologic evaluation of the depth of necrosis produced by argon beam coagulation: implications for use as adjuvant treatment of bone tumors. J Surg Orthop Adv; 2009;18(2):69-73
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  • [Title] Histologic evaluation of the depth of necrosis produced by argon beam coagulation: implications for use as adjuvant treatment of bone tumors.
  • Argon beam coagulation (ABC) has been advocated as adjuvant treatment after curettage of aggressive benign bone tumors.
  • This study was done to evaluate the depth of necrosis in cancellous bone treated with ABC.
  • A 6-month-old pig was sacrificed and 20 1.5-cm cortical windows were created in the metaphyseal areas of the humeri, femora, and tibiae, exposing the underlying cancellous bone.
  • [MeSH-major] Bone Neoplasms / surgery. Bone and Bones / pathology. Laser Coagulation / instrumentation. Lasers, Excimer / therapeutic use

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  • (PMID = 19602333.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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78. Adams SC, Potter BK, Robinson PG, Temple HT: Giant cell tumor of the distal femur associated with complete tumor necrosis. Orthopedics; 2010 Sep;33(9):688
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  • [Title] Giant cell tumor of the distal femur associated with complete tumor necrosis.
  • Giant cell tumor is a benign tumor of bone with a predilection for juxta-articular locations.
  • Although not malignant, giant cell tumor often exhibits unpredictable and locally aggressive behavior, and in rare cases can metastasize in the absence of histologic malignancy.
  • Partial tumor necrosis has been infrequently reported within typical giant cell tumor.
  • A 17-year-old girl presented with a right distal femur giant cell tumor associated with complete tumor necrosis on histopathologic analysis.
  • The etiology, prevalence, and implications of complete necrosis in previously untreated giant cell tumor of bone remain unclear, as there are no previously published reports.
  • There were no radiographic signs of the necrotic tumor space remodeling with new bone.
  • The patient was treated with standard extended intralesional curetting through a generous cortical window permitting visualization of the entire lesion, and systematic high speed burring and thermal electrocautery ablation of the periphery, followed by micro particulate allogenic bone grafting.
  • At short-term follow-up, she had healed well with no evidence of tumor recurrence.
  • This article presents the first case, to our knowledge, of complete spontaneous tumor necrosis in a previously untreated bone giant cell tumor.
  • Increased understanding of spontaneous tumor necrosis associated with giant cell tumor may help guided future targeted medical and surgical treatment modalities.
  • [MeSH-major] Femoral Neoplasms / pathology. Giant Cell Tumor of Bone / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20839701.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Al-Balas H, Omari H, Mustafa Z, Matalka I: Osteoid osteoma of the odontoid process of the axis associated with atlanto-axial fusion. Br J Radiol; 2009 Jul;82(979):e126-8
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  • Osteoid osteoma is a primary benign bone tumour with characteristic imaging and pathological features.
  • The case was diagnosed pre-operatively using plain radiography, multiplanar helical CT, contrast-enhanced MRI and radioisotope bone scanning.
  • [MeSH-major] Atlanto-Axial Joint / abnormalities. Odontoid Process. Osteoma, Osteoid / diagnosis. Spinal Neoplasms / diagnosis

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  • (PMID = 19541938.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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80. Tsai WC, Liao CJ, Wu CT, Liu CY, Lin SC, Young TH, Wu SS, Liu HC: Clinical result of sintered bovine hydroxyapatite bone substitute: analysis of the interface reaction between tissue and bone substitute. J Orthop Sci; 2010 Mar;15(2):223-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical result of sintered bovine hydroxyapatite bone substitute: analysis of the interface reaction between tissue and bone substitute.
  • BACKGROUND: Autogenic bone graft is the first choice for managing bone defects.
  • However, donor site-associated morbidity and limited bone volume are constraints in clinical applications.
  • Allografts can provide sufficient amounts for bone defects but have a high risk of infection.
  • Bone substitute composed of hydroxyapatite (HA) is an alternative material for avoiding the aforementioned risks.
  • Sintered bovine bone is a naturally occurring HA that has been proved to have excellent bioactivity for inducing osteoblastic expression and new bone formation in animal studies.
  • The objective of this study was to evaluate the interactions between the tissue and the bone substitute composed of HA (sintered from bovine bone) in the human body.
  • METHODS: From 2003 to 2005, a total of 33 patients were enrolled to receive the sintered bovine HA as a bone substitute.
  • Inclusion criteria were fractures with bony defects, benign bone tumors with a cavity, and spinal fusions.
  • Bone healing was monitored by a series of radiographs, and bone microstructure was checked by scanning electron microscopy (SEM) and von Kossa staining.
  • New bone formation on the surface of the sintered bovine HA was seen under microscopic observation.
  • Tight bonding between the interface of the bone and the sintered bovine HA was shown with SEM/energy-dispersive spectroscopy and von Kossa staining.
  • CONCLUSIONS: Sintered bovine HA is a suitable material as a bone substitute to provide bone growth and promote bone healing.
  • [MeSH-major] Biocompatible Materials / therapeutic use. Bone Substitutes. Durapatite / therapeutic use. Fractures, Bone / surgery. Spinal Fusion / methods

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  • (PMID = 20358336.001).
  • [ISSN] 1436-2023
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 91D9GV0Z28 / Durapatite
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81. Ozalp T, Yercan H, Okçu G, Ozdemir O, Coskunol E, Bégué T, Calli I: [Giant-cell tumor of the hand: midterm results in five patients]. Rev Chir Orthop Reparatrice Appar Mot; 2007 Dec;93(8):842-7
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  • [Title] [Giant-cell tumor of the hand: midterm results in five patients].
  • [Transliterated title] Tumeur à cellules géantes de la main: résultats du traitement: 5 cas au recul moyen de 7, 8 ans.
  • PURPOSE OF THE STUDY: Giant-cell bone tumors are benign but have great potential for recurrence.
  • Frequently observed in epiphyseal areas of tubular bones, these tumors are rarely found in hand localizations.
  • We examined the characteristic features of giant-cell tumors of the hand and analyzed the pertinence of surgical treatment.
  • We noted complications, consequences of recurrence and later operations on the same tumor site in five cases.
  • CASE REPORTS: Five patients treated between 1973 and 2000 for giant-cell tumors involving the hand bones were reviewed retrospectively.
  • The surgical procedure was curettage for two, curettage with bone graft for two and amputation for one.
  • At 7.8 years follow-up recurrence was noted for four of the five tumors.
  • In all six episodes of recurrent tumor were treated.
  • DISCUSSION: Treatment of giant-cell tumors involving the hand bones is designed to eradicate the tumor and also protect hand function while keeping in mind the aggressive nature of these benign tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumors / surgery. Hand Bones / surgery
  • [MeSH-minor] Adult. Aged. Amputation. Bone Transplantation. Curettage. Female. Finger Phalanges / surgery. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Soft Tissue Neoplasms / surgery. Thumb / surgery. Time Factors. Treatment Outcome

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  • (PMID = 18166957.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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82. Ozturk C, Tezer M, Hamzaoglu A: Solitary osteochondroma of the cervical spine causing spinal cord compression. Acta Orthop Belg; 2007 Feb;73(1):133-6
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  • Osteochondromas are common benign tumours of bone that often occur in the metaphysodiaphyseal parts of long bones.
  • Radiographs, CT and MRI showed a solitary benign appearing expansile bone tumour arising from the left vertebral lamina of C-1, spreading to C-2, exerting an eccentric posterolateral compression on the spinal cord in the left part of the spinal canal and causing stenosis of the left neural foramen between C-1 and C-2.
  • [MeSH-minor] Bone Screws. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neck Pain / etiology. Orthopedic Fixation Devices. Spinal Fusion. Spinal Stenosis / etiology. Tomography, X-Ray Computed

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  • (PMID = 17441673.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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83. Akhlaghpoor S, Aziz Ahari A, Ahmadi SA, Arjmand Shabestari A, Gohari Moghaddam K, Alinaghizadeh MR: Histological evaluation of drill fragments obtained during osteoid osteoma radiofrequency ablation. Skeletal Radiol; 2010 May;39(5):451-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Osteoid osteoma (OO) is a benign bone tumor diagnosed mainly on the basis of the patient's history and radiological data.
  • The aim of this study was to assess the diagnostic value of a histological evaluation of the bone fragments obtained during radiofrequency ablation (RFA).
  • Bone fragments collected from the drill were examined by two experienced pathologists, independently.
  • In 27 cases (69.2%) this diagnosis was confirmed pathologically.
  • CONCLUSION: Histological confirmation of OO based on drill fragments is similarly frequent as previously reported for standard bone biopsy.
  • [MeSH-major] Biopsy / methods. Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Bone and Bones / pathology. Catheter Ablation / methods. Osteoma, Osteoid / diagnosis. Osteoma, Osteoid / surgery

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  • [Cites] Skeletal Radiol. 2004 Mar;33(3):181-5 [14740185.001]
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  • (PMID = 20204353.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
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84. Futani H, Fukunaga S, Nishio S, Yagi M, Yoshiya S: Successful treatment of bilateral calcaneal intraosseous lipomas using endoscopically assisted tumor resection. Anticancer Res; 2007 Nov-Dec;27(6C):4311-4
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  • [Title] Successful treatment of bilateral calcaneal intraosseous lipomas using endoscopically assisted tumor resection.
  • BACKGROUND: Intraosseous lipoma is a rare benign bone tumor.
  • Curettage was performed through small bone fenestrations in the medial and lateral aspects under observation with a 2.7-mm-diameter Hopkins telescope.
  • The bone void was filled with beta-tricalcium phosphate (beta-TCP).
  • CONCLUSION: Endoscopically assisted curettage is feasible in patients with benign bone tumors of the calcanei to avoid a long period of non-weightbearing post-operatively.
  • [MeSH-major] Bone Neoplasms / surgery. Calcaneus / surgery. Curettage / methods. Endoscopy. Lipoma / surgery

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  • (PMID = 18214037.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Calcium Phosphates; 0 / beta-tricalcium phosphate
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85. Liu H, Sun J, Wang Y, Yang X, Zhu E: [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Nov;22(11):1349-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow].
  • OBJECTIVE: To investigate the clinical application of grafting with bioactive glass (BG) and autologous bone marrow for defect after resection and curettage of benign bone neoplasm.
  • METHODS: From January 2004 to May 2007, 34 patients with bone defects were repaired.
  • There were 14 cases of simple bone cysts, 6 cases of fibrous dysplasia, 3 cases of osteoid osteoma, 4 cases of non-ossifying fibroma, 2 cases of enchondroma and 3 cases of giant cell tumor of bone.
  • Tumor sizes varied from 2.0 cm x 1.5 cm x 1.0 cm to 9.0 cm x 3.0 cm x 2.5 cm.
  • Benign bone neoplasm was removed thoroughly with a curet or osteotome, bone defects ranged from 3.0 cm x 2.0 cm x 1.5 cm to 11.0 cm x 3.5 cm x 3.0 cm, which was closed-up with the mixtures of BG and autogenous red bone marrow.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone healing.
  • At averaged 16 weeks after operation, patients with bone tumor in lower limbs resumed walking independently and those with bone tumor in upper limbs resumed holding object.
  • There was no tumor recurrence during follow-up.
  • Radiographically, the interface between the implanted bone and host bone became fuzzy 1 month after implantation.
  • Two months after operation, the BG was absorbed gradually, new bone formation could be seen in the defects.
  • Four months after operation, implanted bone and host bone merged together, bone density increased.
  • Six to ten months after operation, the majority of the implanted BG was absorbed and substituted for new bone, bone remodeling was established.
  • CONCLUSION: BG may boast both bone conductive and bone inductive activities.
  • The combined grafting with BG and autologous bone marrow appears to be minimally invasive treatment to repair bone defects of benign bone neoplasm, with rare complications and no significant reverse reaction, and could repair bone defects completely.
  • [MeSH-major] Bone Marrow Transplantation. Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Bone and Bones / pathology. Child. Female. Follow-Up Studies. Glass. Humans. Male. Middle Aged. Transplantation, Autologous

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  • (PMID = 19068605.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes
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86. Simsek A, Sipahioğlu S, Ataoğlu O, Cila E: Clear cell chondrosarcoma of the proximal femur with intrapelvic extension. Arch Orthop Trauma Surg; 2005 Feb;125(1):66-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell chondrosarcoma is a rare tumor that can be easily confused with benign tumors.
  • The aim of this report is to present a case that is rare, initially diagnosed as aneurysmal bone cyst and then chondroblastoma, and has an interesting extension pattern.
  • A 41-year-old male patient was treated for an apparently benign cystic lesion of the right proximal femur by intralesional excision and bone grafting.
  • The pathological diagnosis was aneurysmal bone cyst.
  • Both tumors were resected with a wide margin on the femoral side and a marginal margin on the intrapelvic side.
  • Again, the pathological diagnosis was chondroblastoma.
  • Clinically and pathologically, clear cell chondrosarcoma may be confused with benign bone tumors.
  • This caused a delay in the final diagnosis of this patient and he received inadequate surgical treatment, leading to a hemipelvectomy.
  • We were unable to find an exact explanation for this finding and postulated that tumor cells might have been seeded into the inner wall of the acetabulum during acetabular preparation of the total hip prosthesis.
  • [MeSH-major] Chondrosarcoma / diagnosis. Femoral Neoplasms / diagnosis. Pelvic Neoplasms / secondary. Sarcoma, Clear Cell / diagnosis

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  • (PMID = 15558292.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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87. Abdulkareem FB, Eyesan SU, Akinde OR, Ezembakwe ME, Nnodu OE: Pathological study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria. West Afr J Med; 2007 Oct-Dec;26(4):306-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria.
  • BACKGROUND: Although primary bone tumours are relatively uncommon, they constitute the most important tumours in patients under 20 years.
  • OBJECTIVE: To update the literature on the relative frequency and clinico-pathologic characteristics of bone tumours in this environment.
  • MATERIALS AND METHODS: The clinical and histopathological records of patients presenting with diagnosis of bone tumours between 1999 and 2004 and managed at the National Orthopaedic Hospital, Igbobi, (NOHI) Lagos, Nigeria were review and where necessary, new ones were prepared from the paraffin blocks and stained with routine haematoxylin and eosin stain.
  • RESULTS: Seventy-seven cases were recorded; 61 (79.2%) benign and 16 (15.6%) malignant.
  • The male:female ratio for all tumours was 2:1.
  • The commonest benign bone tumours were osteochondroma and giant cell tumour accounting for 52 (67%) of all cases with > 60% in males.
  • The most common primary malignant bone tumour was osteosarcoma, all in males.
  • Four (5.2%) cases of metastatic bone tumours located commonly in the proximal femur and humerus were also recorded.
  • CONCLUSION: Osteochondroma and giant cell tumours are the commonest benign tumours while osteosarcoma is the most common primary bone tumour all occurring in the first two decades of life.
  • [MeSH-major] Bone Neoplasms / pathology

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  • (PMID = 18705432.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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88. Cantwell CP, Scanlon T, Dudeney S, O'Byrne J, Eustace S: CT guided radiofrequency ablation of intra-articular osteoid osteoma of the hip. Ir J Med Sci; 2005 Jul-Sep;174(3):97-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteoid osteoma is a painful benign bone tumour.
  • Image guided radiofrequency ablation can be clinically applied to ablate the tumour in a minimally invasive manner.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation. Hip / physiopathology. Joint Diseases / therapy. Osteoma, Osteoid / surgery

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  • (PMID = 16285350.001).
  • [ISSN] 0021-1265
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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89. Marioni G, Marchese-Ragona R, Guarda-Nardini L, Stramare R, Tognazza E, Marino F, Staffieri A: Giant cell tumour (central giant cell lesion) of the maxilla. Acta Otolaryngol; 2006 Jul;126(7):779-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour (central giant cell lesion) of the maxilla.
  • The giant cell tumour (GCT) is a benign, locally invasive lesion that accounts for about 20% of benign bone tumours.
  • Our successful maxillary reconstruction based on the association between autologous calvarial bone sticks bent with titanium miniplates and a temporalis muscle pedicled flap allowed the involvement of only one donor area for both hard and soft tissues.
  • [MeSH-major] Giant Cell Tumor of Bone / diagnosis. Giant Cell Tumor of Bone / surgery. Maxillary Neoplasms / diagnosis. Maxillary Neoplasms / surgery

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  • (PMID = 16803721.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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90. Wang J, Pei F, Tu C, Zhang H, Qiu X: Serum bone turnover markers in patients with primary bone tumors. Oncology; 2007;72(5-6):338-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum bone turnover markers in patients with primary bone tumors.
  • OBJECTIVES: It was the aim of this study to investigate parameters of bone turnover such as serum bone-specific alkaline phosphatase (BALP) and N-terminal midfragment of osteocalcin (N-MID), as well as serum C-terminal telopeptide of type I collagen (CTX) in patients with primary bone tumors and to investigate their validity in differentiating malignant from benign bone tumors.
  • METHODS: A total of 219 patients with primary bone tumors entered the study.
  • In each group, the patients were divided into several subgroups (osteosarcoma, benign bone tumors or tumor-like lesions, giant cell tumor, and other primary malignant bone tumors).
  • CONCLUSIONS: A high serum BALP level is valuable for the diagnosis of adult osteosarcoma, but its use in the development of a differential diagnosis in the teenage patients is not advised because serum BALP levels are also affected by age, pubertal stage and growth velocity.
  • Both serum N-MID and serum CTX are hardly useful in the differential diagnosis of primary bone tumors.
  • [MeSH-major] Alkaline Phosphatase / blood. Biomarkers, Tumor / blood. Bone Neoplasms / blood. Bone Neoplasms / metabolism

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18187955.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Collagen Type I; 104982-03-8 / Osteocalcin; EC 3.1.3.1 / Alkaline Phosphatase
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91. Sponer P, Urban K, Urbanová E: [Scintigraphic detection of osteoblast activity after implantation of BAS-0 bioactive glass-ceramic material into long bone defects]. Acta Chir Orthop Traumatol Cech; 2006 Jun;73(3):176-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Scintigraphic detection of osteoblast activity after implantation of BAS-0 bioactive glass-ceramic material into long bone defects].
  • PURPOSE OF THE STUDY: The aim of the study was to demonstrate, by three-phase bone scintigraphy, radionuclide uptake at the site of defects in long bones filled with the non-resorbable bioactive glass-ceramic material BAS-0 at a long follow-up.
  • MATERIAL: Twenty patients, 14 men and 6 women, operated on between 1990 and 2000 for benign bone tumors or tumor-like lesions localized in the femur, tibia or humerus were comprised in the study.
  • The diagnoses based on histological examination included juvenile bone cysts in 11, aneurysmal bone cyst in five, non-ossifying fibroma in two, and fibrous dysplasia in two patients.
  • Three-phase bone scans were made and the healthy and the affected limbs in each patient were compared by means of an index.
  • On three-phase bone scans, radionuclide distribution on the flow phase and soft tissue phase was symmetrical in both limbs of all patients.
  • This changes local mechanical signals, which has a negative effect on the adjacent bone tissue.
  • Stress accumulating at the interface of a rigid implant and bone tissue may result in pain, and is detected by scintigraphy as an increased nucleotide uptake, particularly in diaphyseal grafts.
  • [MeSH-major] Bone Diseases / therapy. Bone Substitutes. Bone and Bones / radionuclide imaging. Ceramics. Osseointegration. Prostheses and Implants

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  • (PMID = 16846563.001).
  • [ISSN] 0001-5415
  • [Journal-full-title] Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca
  • [ISO-abbreviation] Acta Chir Orthop Traumatol Cech
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / BAS O glass ceramic; 0 / Bone Substitutes
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92. Zuntini M, Pedrini E, Parra A, Sgariglia F, Gentile FV, Pandolfi M, Alberghini M, Sangiorgi L: Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation. Oncogene; 2010 Jul 1;29(26):3827-34
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  • Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome.
  • Although both benign conditions have been linked to defects in EXT1 or EXT2 genes, contradictory reports are present in the literature regarding the requirement of their biallelic inactivation for osteochondroma development.
  • Our results clearly indicate that, in most cases, biallelic inactivation of EXT genes does not account for osteochondromas formation; this mechanism should be regarded as a common feature for hereditary osteochondromas transformation and as an event that occurs later in tumor progression of solitary cases.
  • [MeSH-major] Bone Neoplasms / genetics. Gene Silencing. N-Acetylglucosaminyltransferases / genetics. Osteochondroma / genetics

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  • (PMID = 20418910.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
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93. Aalderink K, Wolf B: Scapular osteochondroma treated with arthroscopic excision using prone positioning. Am J Orthop (Belle Mead NJ); 2010 Feb;39(2):E11-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondromas, or exostoses, are common benign bone tumors.
  • [MeSH-major] Arthroscopy / methods. Bone Neoplasms / pathology. Osteochondroma / pathology. Scapula / pathology

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  • (PMID = 20396684.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Teka A, Admassie D, Schneider J: Osteochondroma of the coccyx: a case report. Ethiop Med J; 2010 Jul;48(3):247-51
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  • Osteochondroma is the most common benign bone tumor.

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  • (PMID = 21073087.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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95. Layadi F, Aniba K, Lmejjati M, Aït Elqadi A, Aït Benali S: [Giant osteoid osteoma of the posterior skull base. A case report and literature review]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):128-32
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  • [Transliterated title] Ostéome ostéoïde géant de l'étage postérieur de la base du crâne. A propos d'un cas et revue de la littérature.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones.
  • Cerebral MRI shows a giant lesion of the posterior cerebral fossa with destruction of the left petrous bone and the left side of the occipital bone.
  • CONCLUSION: Although benign and rare, osteoid osteoma can present with neurological deficit due to mass effect and involvement of nervous structures especially in the posterior skull base.

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  • (PMID = 16840973.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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96. Lee VN, Nithyananth M, Cherian VM, Amritanand R, Venkatesh K, Sundararaj GD, Raghuram LN: Preoperative embolisation in benign bone tumour excision. J Orthop Surg (Hong Kong); 2008 Apr;16(1):80-3
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  • [Title] Preoperative embolisation in benign bone tumour excision.
  • PURPOSE: To assess the role of preoperative embolisation in benign bone tumour excision.
  • METHODS: 3 men and 3 women aged 19 to 35 (mean 23) years with either a giant cell tumour or an aneurysmal bone cyst in limb girdle sites underwent preoperative embolisation a day prior to wide local excision by the same surgeon.
  • Tumour size, blood loss, wound healing, infection, and tumour recurrence were assessed.
  • No tumour recurred within a minimum 5-year follow-up.
  • CONCLUSION: Preoperative embolisation is useful in the management of vascular and aggressive bone tumours located at limb girdle sites where a tourniquet cannot be used.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Bone Neoplasms / surgery. Embolization, Therapeutic. Giant Cell Tumor of Bone / surgery. Preoperative Care

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  • (PMID = 18453665.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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97. Arkader A, Dormans JP, Gaugler R, Davidson RS: Spontaneous regression of solitary osteochondroma: reconsidering our approach. Clin Orthop Relat Res; 2007 Jul;460:253-7
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  • Osteochondromas are the most common benign bone tumor; nonetheless, the natural history is poorly understood as a result of the low threshold for resection and the fact that many of these lesions are asymptomatic and therefore never diagnosed.
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Remission, Spontaneous

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  • (PMID = 17620816.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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98. Forsyth RG, De Boeck G, Bekaert S, De Meyer T, Taminiau AH, Uyttendaele D, Roels H, Praet MM, Hogendoorn PC: Telomere biology in giant cell tumour of bone. J Pathol; 2008 Apr;214(5):555-63
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  • [Title] Telomere biology in giant cell tumour of bone.
  • Giant cell tumour of bone (GCTB) is a benign bone tumour known for the unpredictable clinical behaviour of recurrences and, in rare instances, distant metastases.
  • GCTB has often been regarded as a polyclonal tumour, but more recently a recurrent specific aberration was reported, which suggests a possible role for disturbed telomere maintenance.
  • [MeSH-major] Bone Neoplasms / genetics. Giant Cell Tumors / genetics. Telomere / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Humans. In Situ Hybridization, Fluorescence. Male. Microscopy, Confocal. Middle Aged. Neoplasm Proteins / metabolism. Nuclear Proteins / metabolism. Osteoclasts / metabolism. Osteoclasts / pathology. Phosphoproteins / metabolism. RNA-Binding Proteins / metabolism. Telomerase / metabolism. Transcription Factors / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland
  • (PMID = 18278785.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / nucleolin; 143220-95-5 / PML protein, human; EC 2.7.7.49 / Telomerase
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99. Zhong Z, Chen Q, Chen Y, Liu C: [Repair of bone defect due to tumor resection with self-setting CPC in children]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Oct;22(10):1196-9
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  • [Title] [Repair of bone defect due to tumor resection with self-setting CPC in children].
  • OBJECTIVE: To summarize the effect of self-setting CPC on the repair of bone defect after tumor resection in children.
  • METHODS: From December 1998 to December 2006, 32 patients with benign bone tumor were treated, and the bone defect was repaired by CPC.
  • There were 12 cases of non-ossifying fibroma, 8 of bone cyst, 7 of osteoid osteoma and 5 of fibrous dysplasia.
  • The bone defect was located in femur in 15 cases, in tibia in 8 cases, in humerus in 6 cases and in other positions in 3 cases.
  • The range of bone defect was 2.0 cm x 1.5 cm x 1.0 cm - 10.0 cm x 5.0 cm x 4.0 cm.
  • CPC spongiosa granules of 3-23 g were filled in 26 cases, including 3 children with pathologic fracture and internal fixation with plate, and injectable CPC of 5-20 mL was filled in 6 bone cyst cases.
  • The X-ray films showed that the implanted CPC began to fuse with the host bone 4-9 months (7 month on average) after operation.
  • Finally, bone matrix grew well and no recurrence was found.
  • CONCLUSION: CPC in repairing bone defect after benign bone tumor in children is a safe, economical, convenient and non-toxic method.
  • [MeSH-major] Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Bone Neoplasms / surgery. Bone Regeneration. Child. Child, Preschool. Female. Humans. Hydroxyapatites. Male. Wound Healing

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  • (PMID = 18979877.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Hydroxyapatites
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100. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • The peak incidence of this neoplasm is in the first two decades of life.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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