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6. Yanagawa T, Watanabe H, Shinozaki T, Takagishi K: Curettage of benign bone tumors without grafts gives sufficient bone strength. Acta Orthop; 2009 Feb;80(1):9-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Curettage of benign bone tumors without grafts gives sufficient bone strength.
  • BACKGROUND AND PURPOSE: The defect that results after curettage of a bone tumor is usually filled in the same way.
  • We report the outcome in patients with benign bone tumors that were treated with curettage but no filling.
  • PATIENTS AND METHODS: We retrospectively studied 78 patients (mean age at the time of operation was 27 (6-73) years, 44 men) who had had a benign bone tumor curetted with no filling of the defect.
  • The commonest tumor types were giant cell tumor of bone (27), fibrous dysplasia (13), enchondroma (9), and simple bone cyst (7).
  • Local recurrence occurred in 9 patients; 7 of them had a giant cell tumor.
  • INTERPRETATION: Routine filling of curetted bone lesions does not appear to be necessary from a mechanical point of view.
  • [MeSH-major] Bone Neoplasms / surgery. Curettage / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Remodeling / physiology. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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  • [CommentIn] Acta Orthop. 2009 Feb;80(1):2-3 [19297784.001]
  • (PMID = 19234882.001).
  • [ISSN] 1745-3682
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Other-IDs] NLM/ PMC2823236
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7. Fukunaga S, Futani H, Yoshiya S: Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome. World J Surg Oncol; 2007;5:37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteochondroma is the most common benign bone tumor in the scapula.
  • Removal of the tumor was performed by the use of endoscopically assisted resection.
  • The tumor was resected in a piece-by-piece manner by the use of graspers through the same portal.
  • CT images showed complete tumor resection.
  • [MeSH-major] Bone Neoplasms / surgery. Endoscopy. Osteochondroma / surgery. Scapula

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  • (PMID = 17378939.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1839090
  • [General-notes] NLM/ Original DateCompleted: 20070726
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8. Liu H, Sun J, Wang Y, Yang X, Zhu E: [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Nov;22(11):1349-53
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  • [Title] [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow].
  • OBJECTIVE: To investigate the clinical application of grafting with bioactive glass (BG) and autologous bone marrow for defect after resection and curettage of benign bone neoplasm.
  • METHODS: From January 2004 to May 2007, 34 patients with bone defects were repaired.
  • There were 14 cases of simple bone cysts, 6 cases of fibrous dysplasia, 3 cases of osteoid osteoma, 4 cases of non-ossifying fibroma, 2 cases of enchondroma and 3 cases of giant cell tumor of bone.
  • Tumor sizes varied from 2.0 cm x 1.5 cm x 1.0 cm to 9.0 cm x 3.0 cm x 2.5 cm.
  • Benign bone neoplasm was removed thoroughly with a curet or osteotome, bone defects ranged from 3.0 cm x 2.0 cm x 1.5 cm to 11.0 cm x 3.5 cm x 3.0 cm, which was closed-up with the mixtures of BG and autogenous red bone marrow.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone healing.
  • At averaged 16 weeks after operation, patients with bone tumor in lower limbs resumed walking independently and those with bone tumor in upper limbs resumed holding object.
  • There was no tumor recurrence during follow-up.
  • Radiographically, the interface between the implanted bone and host bone became fuzzy 1 month after implantation.
  • Two months after operation, the BG was absorbed gradually, new bone formation could be seen in the defects.
  • Four months after operation, implanted bone and host bone merged together, bone density increased.
  • Six to ten months after operation, the majority of the implanted BG was absorbed and substituted for new bone, bone remodeling was established.
  • CONCLUSION: BG may boast both bone conductive and bone inductive activities.
  • The combined grafting with BG and autologous bone marrow appears to be minimally invasive treatment to repair bone defects of benign bone neoplasm, with rare complications and no significant reverse reaction, and could repair bone defects completely.
  • [MeSH-major] Bone Marrow Transplantation. Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Bone and Bones / pathology. Child. Female. Follow-Up Studies. Glass. Humans. Male. Middle Aged. Transplantation, Autologous

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  • (PMID = 19068605.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes
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9. Daghfous M, Charfi H, Turki M, Maalla R, Baccari S, Tarhouni L: [Chondromyxoid fibroma. A case report of location in the phalanx of the thumb]. Chir Main; 2007 Jun;26(3):159-64
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  • Chondromyxoid Fibroma is a rare benign osseous tumor especially in the hand, because the hand represents less than 3% of all osseous locations.
  • It can causes problems of differential diagnosis with several types of tumors and in particular with chondrosarcoma, for which the management is totally different.
  • We report a case of location of a chondromyxoid fibroma in a phalanx of the thumb, which caused problems of differential diagnosis with chondroma and chondrosarcoma.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroblastoma / pathology. Fibroma / pathology. Thumb / pathology

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  • (PMID = 17590372.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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10. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Tamai N, Myoui A, Kudawara I, Ueda T, Yoshikawa H: Novel fully interconnected porous hydroxyapatite ceramic in surgical treatment of benign bone tumor. J Orthop Sci; 2010 Jul;15(4):560-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Novel fully interconnected porous hydroxyapatite ceramic in surgical treatment of benign bone tumor.
  • BACKGROUND: Large bone defects remaining after curettage of benign bone tumors should be filled with a substitute to restore mechanical strength.
  • In 2000, we developed a fully interconnected porous calcium hydroxyapatite ceramic (IPCHA, NEOBONE) and have utilized it as a bone substitute.
  • The large interconnecting channels (average diameter 40 microm) permit easy penetration of tissue into the deep pores, so IP-CHA can itself induce local bone repair processes.
  • The purpose of this study was to evaluate the clinical outcomes with the use of IP-CHA as bone substitute after curettage of benign bone tumors.
  • METHODS: We reviewed the results of 71 patients with benign bone tumors sequentially treated by curettage followed by implantation of IP-CHA between 2000 and 2006.
  • Radiographic findings were classified into five stages: stage 0, no change; stage 1, slight bone formation; stage 2, moderate bone formation; stage 3, consolidation; stage 4, absorption.
  • However, there were 10 local recurrences, which is similar to the recurrence rate for such tumors treated with or without implantation of CHAs and reflects the biological nature of each tumor.
  • CONCLUSIONS: In this study, we utilized IP-CHA as a bone substitute after curettage of benign bone tumors and demonstrated its usefulness in the clinical situation.
  • IP-CHA comparatively exhibited excellent bone formation at an early stage although the problem of recurrence of the tumor remained.
  • We conclude that IP-CHA is a useful bone substitute for the treatment of benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Ceramics / therapeutic use. Durapatite / therapeutic use. Osteogenesis
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Substitutes / therapeutic use. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • Hazardous Substances Data Bank. HYDROXYAPATITE .
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  • (PMID = 20721726.001).
  • [ISSN] 1436-2023
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bone Substitutes; 91D9GV0Z28 / Durapatite
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12. Li J, Wang ZQ, Zhang YM, Song HP, Yuan L: [Application of allogeneic bone in surgical treatment of benign bone neoplasm]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jul;26(7):987-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Application of allogeneic bone in surgical treatment of benign bone neoplasm].
  • OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone.
  • METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft.
  • RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation.
  • The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery.
  • CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods

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  • (PMID = 16864094.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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13. Güneş D, Mutafoğlu-Uysal K, Sarialioğlu F, Cakmakçi H, Olgun N: Aneurysmal bone cyst of rib presenting as a huge chest wall mass. Turk J Pediatr; 2009 Jan-Feb;51(1):82-5

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  • [Title] Aneurysmal bone cyst of rib presenting as a huge chest wall mass.
  • Aneurysmal bone cyst is a rare benign tumor of the bone that can be difficult to distinguish from malignant tumors, especially when it presents in an unusual location.
  • Herein, we report a six-year-old girl with a primary aneurysmal bone cyst in an uncommon location.
  • She was successfully treated with total excision of tumor without any complication.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Ribs. Thoracic Wall / pathology

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  • (PMID = 19378899.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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4. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Chakrapani SD, Grim K, Kaimaktchiev V, Anderson JC: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976); 2008 Dec 1;33(25):E968-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY OF BACKGROUND DATA: Osteoblastoma is a rare benign tumor of bone that is known to incite a localized inflammatory response.
  • These inflammatory features can simulate malignant behavior on MRI and can lead to misdiagnosis and unnecessarily aggressive resection unless one recognizes the classic benign features on CT.
  • RESULTS: A 9-year-old girl with back pain receives an MRI of the lumbar spine demonstrating a sacral tumor with potentially malignant features including extensive marrow edema and enhancement.
  • A CT demonstrates a well-circumscribed lesion without lytic changes or malignant bone formation.
  • A benign lesion was favored given the CT features and conservative resection was performed.
  • Final pathologic diagnosis was osteoblastoma.
  • CONCLUSION: This case illustrates that the MRI findings for osteoblastoma can be misleading and caution should be used when evaluating benign tumors with known inflammatory responses on MRI.
  • CT features seem to more accurately reflect the true nature and extent of the tumor.
  • [MeSH-major] Magnetic Resonance Imaging. Osteoblastoma / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Inflammation / diagnosis. Inflammation / radiography. Inflammation / surgery. Lumbar Vertebrae / pathology. Lumbar Vertebrae / radiography. Lumbar Vertebrae / surgery

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  • (PMID = 19050575.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Pans S, Brys R, Van Breuseghem I, Geusens E: Benign bone tumours of the spine. JBR-BTR; 2005 Jan-Feb;88(1):31-7
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  • [Title] Benign bone tumours of the spine.
  • A wide variety of primary bone tumours can involve the spine.
  • We present an overview of the primary benign bone tumours of the spine.
  • [MeSH-major] Magnetic Resonance Imaging. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Spinal Diseases / diagnosis

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  • (PMID = 15792167.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 16
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17. Li Y, Liang Q, Wen YQ, Chen LL, Wang LT, Liu YL, Luo CQ, Liang HZ, Li MT, Li Z: Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. Cancer Genet Cytogenet; 2010 Apr 15;198(2):97-106
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative proteomics analysis of human osteosarcomas and benign tumor of bone.
  • Proteins extracted from osteosarcoma tissue and benign bone tumors, including osteoblastoma, chondroblastoma, and giant cell tumor of bone, were examined using two-dimensional gel electrophoresis followed by mass spectrometry analysis and database searches.
  • Aberrant expression of cytoskeletal- and microtubule-associated proteins in osteosarcoma may provide an advantage for tumor invasion and metastasis by affecting the stability of microtubule, which consequently influences the prognosis of patients.
  • [MeSH-major] Bone Neoplasms / metabolism. Neoplasm Proteins / analysis. Osteoblastoma / metabolism. Osteosarcoma / metabolism. Proteomics / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Bone and Bones / metabolism. Bone and Bones / pathology. Child. Chondroblastoma / metabolism. Chondroblastoma / pathology. Female. Giant Cell Tumor of Bone / metabolism. Giant Cell Tumor of Bone / pathology. Humans. Male. Middle Aged. Proteome / analysis. Proteome / metabolism. Young Adult


18. Taleb C, Gouzou S, Mantovani G, Liverneaux P: Treatment of benign bone tumours of the hand using osteoscopy. Chir Main; 2010 Apr;29(2):78-81
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  • [Title] Treatment of benign bone tumours of the hand using osteoscopy.
  • Curettage and bone grafting are used traditionally to treat benign bone tumours of the hand.
  • This is a report on three benign metacarpal bone tumours treated with three different endoscopic approaches: multiportal, extended uniportal and oblique uniportal.
  • In theory, the multiportal approach has several drawbacks: weakening of the bone cortex, a limited visual field and seepage of injectable phosphocalcic cement.
  • The oblique uniportal approach seems less troublesome; vision of the bone cavity is good, curettage of the tumour is complete, the bone cortex is undamaged and there is no leakage of injectable phosphocalcic cement.
  • All things considered, the oblique osteoscopic uniportal approach seems to be the best option for the management of benign bone tumours of the hand.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Curettage / methods. Endoscopy / methods. Metacarpal Bones
  • [MeSH-minor] Adult. Bone Cements / therapeutic use. Bone Diseases, Developmental / surgery. Chondroma / surgery. Clinical Protocols. Female. Fluoroscopy. Humans. Male. Neoplasm Recurrence, Local / prevention & control. Treatment Outcome

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20153235.001).
  • [ISSN] 1769-6666
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Cements
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19. Adams SC, Potter BK, Robinson PG, Temple HT: Giant cell tumor of the distal femur associated with complete tumor necrosis. Orthopedics; 2010 Sep;33(9):688
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the distal femur associated with complete tumor necrosis.
  • Giant cell tumor is a benign tumor of bone with a predilection for juxta-articular locations.
  • Although not malignant, giant cell tumor often exhibits unpredictable and locally aggressive behavior, and in rare cases can metastasize in the absence of histologic malignancy.
  • Partial tumor necrosis has been infrequently reported within typical giant cell tumor.
  • A 17-year-old girl presented with a right distal femur giant cell tumor associated with complete tumor necrosis on histopathologic analysis.
  • The etiology, prevalence, and implications of complete necrosis in previously untreated giant cell tumor of bone remain unclear, as there are no previously published reports.
  • There were no radiographic signs of the necrotic tumor space remodeling with new bone.
  • The patient was treated with standard extended intralesional curetting through a generous cortical window permitting visualization of the entire lesion, and systematic high speed burring and thermal electrocautery ablation of the periphery, followed by micro particulate allogenic bone grafting.
  • At short-term follow-up, she had healed well with no evidence of tumor recurrence.
  • This article presents the first case, to our knowledge, of complete spontaneous tumor necrosis in a previously untreated bone giant cell tumor.
  • Increased understanding of spontaneous tumor necrosis associated with giant cell tumor may help guided future targeted medical and surgical treatment modalities.
  • [MeSH-major] Femoral Neoplasms / pathology. Giant Cell Tumor of Bone / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20839701.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Sierra RJ, Cabanela ME: Total hip arthroplasty in patients with underlying fibrous dysplasia. Orthopedics; 2009 May;32(5):320
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fibrous dysplasia is a developmental anomaly of bone formation that accounts for approximately 7% of benign bone tumors.
  • The results of THA in patients with this disorder is not known.
  • [MeSH-major] Arthroplasty, Replacement, Hip / instrumentation. Arthroplasty, Replacement, Hip / methods. Fibrous Dysplasia of Bone / complications. Fibrous Dysplasia of Bone / surgery. Hip Joint / surgery. Joint Instability / etiology. Joint Instability / surgery

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  • (PMID = 19472968.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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21. Kim MS, Lee SY, Cho WH, Song WS, Koh JS, Lee JA, Yoo JY, Shin DS, Jeon DG: Prognostic effects of doctor-associated diagnostic delays in osteosarcoma. Arch Orthop Trauma Surg; 2009 Oct;129(10):1421-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Initial clinical impressions were of a benign bone tumor in 15 patients, fracture in 8, and infection in 3.
  • After initial inappropriate procedures, primary surgeons failed to send a tissue sample to a pathologist for definite diagnosis in 12 cases, and pathologists made incorrect diagnoses in the other 14.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteosarcoma / diagnosis

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  • (PMID = 19280203.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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22. Orhan Z, Oktas B, Yildirim U: An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: a case report. Knee Surg Sports Traumatol Arthrosc; 2009 May;17(5):518-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis (PVS) is a benign proliferative disorder of unknown origin that affects synovial joints, most commonly the knee.
  • Although this disease is categorized as an inflammatory process rather than a neoplasm, it may be locally destructive and involve muscles, tendons, bone and skin.
  • [MeSH-major] Peroneal Neuropathies / diagnosis. Peroneal Neuropathies / etiology. Synovitis, Pigmented Villonodular / complications. Synovitis, Pigmented Villonodular / diagnosis

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  • [Cites] Knee. 2007 Oct;14 (5):390-4 [17600720.001]
  • [Cites] Arthroscopy. 2001 May;17(5):527-31 [11337722.001]
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  • [Cites] Clin Orthop Relat Res. 1996 Apr;(325):174-80 [8998871.001]
  • (PMID = 19205665.001).
  • [ISSN] 1433-7347
  • [Journal-full-title] Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
  • [ISO-abbreviation] Knee Surg Sports Traumatol Arthrosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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23. Ramboaniaina S, Hoang DV, Berger M: [Aneurysmal carpal scaphoid cyst. A case report]. Chir Main; 2009 Feb;28(1):46-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aneurysmal bone cyst is a rare, benign bone tumor and its location in the carpal scaphoid has never been described in the literature.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Scaphoid Bone / radiography

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  • (PMID = 19095484.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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24. Niethard M, Rogalski M, Deja M, Zacher J: [Partial physeal growth arrest with increasing genu varum deformity caused by a cortical enchondroma--a case report]. Z Orthop Unfall; 2008 Nov-Dec;146(6):725-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The X-ray and MRI investigations have shown a benign lesion like osteofibroma of the mediodistal femur with an affection of the medial physis.
  • 1) resection of the benign lesion and arthroscopically assisted resection of the bony bar with fat-patch interposition;.
  • CONCLUSION: In cases of rare partial bridging of the physis induced by a benign bone tumour one can achieve early correction of axial deviation during growth with resection, interposition of a fat patch and temporary hemiepiphyseodesis.
  • [MeSH-major] Arthroscopy. Bone Malalignment / surgery. Bone Plates. Cartilage, Articular / surgery. Chondroma / surgery. Femur / surgery. Growth Plate / surgery. Knee Joint / surgery

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  • (PMID = 19085720.001).
  • [ISSN] 1864-6697
  • [Journal-full-title] Zeitschrift für Orthopädie und Unfallchirurgie
  • [ISO-abbreviation] Z Orthop Unfall
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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25. Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M: Osteochondromas: review of the clinical, radiological and pathological features. In Vivo; 2008 Sep-Oct;22(5):633-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones.
  • This tumor takes the form of a cartilage-capped bony outgrowth on the surface of the bone.
  • Approximately 15% of osteochondromas occur as multiple lesions in the context of hereditary multiple osteochondromas (HMOs), a disorder that is inherited in an autosomal dominant manner.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Osteochondroma / pathology. Osteochondroma / radiography

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  • (PMID = 18853760.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 125
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26. Moon IS, Kim J, Lee HK, Lee WS: Surgical treatment and outcomes of temporal bone chondroblastoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1447-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment and outcomes of temporal bone chondroblastoma.
  • Chondroblastoma is an uncommon primary benign bone tumor that usually arises in the epiphyses of the long bones.
  • Temporal bone chondroblastoma is a rare primary bone tumor that affects the floor of the middle cranial fossa and temporomandibular joint (TMJ).
  • The biological nature of temporal bone chondroblastoma is occasionally aggressive because of local invasion and is known to have a high recurrence after curettage.
  • The authors have retrospectively analyzed four cases of temporal bone chondroblastoma that had been completely excised by a single surgeon with an eventual long-term follow-up.
  • In all cases, the tumor involved the middle cranial fossa dura and the mandibular fossa with variable degree of infiltration.
  • All patients have had no tumor recurrence to date (mean follow-up period of 5 years).
  • Complete surgical resection of the temporal bone chondroblastoma is the gold standard for treatment.
  • Precise preoperative image evaluation of tumor extension and proper management of the dura mater and temporomandibular joint (TMJ) are the major important features in complete surgical removal that minimize complications in temporal bone chondroblastoma treatment.
  • [MeSH-major] Chondroblastoma / surgery. Skull Neoplasms / surgery. Temporal Bone

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  • (PMID = 18401591.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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27. Forsyth RG, De Boeck G, Bekaert S, De Meyer T, Taminiau AH, Uyttendaele D, Roels H, Praet MM, Hogendoorn PC: Telomere biology in giant cell tumour of bone. J Pathol; 2008 Apr;214(5):555-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Telomere biology in giant cell tumour of bone.
  • Giant cell tumour of bone (GCTB) is a benign bone tumour known for the unpredictable clinical behaviour of recurrences and, in rare instances, distant metastases.
  • GCTB has often been regarded as a polyclonal tumour, but more recently a recurrent specific aberration was reported, which suggests a possible role for disturbed telomere maintenance.
  • [MeSH-major] Bone Neoplasms / genetics. Giant Cell Tumors / genetics. Telomere / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Humans. In Situ Hybridization, Fluorescence. Male. Microscopy, Confocal. Middle Aged. Neoplasm Proteins / metabolism. Nuclear Proteins / metabolism. Osteoclasts / metabolism. Osteoclasts / pathology. Phosphoproteins / metabolism. RNA-Binding Proteins / metabolism. Telomerase / metabolism. Transcription Factors / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland
  • (PMID = 18278785.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / nucleolin; 143220-95-5 / PML protein, human; EC 2.7.7.49 / Telomerase
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28. Durand S, Hamcha H, Pannier S, Padovani JP, Finidori G, Glorion C: [Fibrous dysplasia of the proximal femur in children and teenagers: surgical results in 22 cases]. Rev Chir Orthop Reparatrice Appar Mot; 2007 Feb;93(1):17-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] La dysplasie fibreuse de l'extrémité proximale du fémur chez l'enfant et l'adolescent: résultats du traitement chirurgical dans 22 cas.
  • PURPOSE OF THE STUDY: Fibrous dysplasia is a rare benign bone tumor which occurs preferentially in the proximal femur.
  • For the monostotic forms, the type of treatment depended on the size of the tumor and its localization but curettage was used in all cases.
  • Nearly total involution of the tumor was noted in 75% of patients.
  • [MeSH-major] Femur / surgery. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Density Conservation Agents / therapeutic use. Bone Nails. Child. Child, Preschool. Cohort Studies. Curettage. Diphosphonates / therapeutic use. Female. Fibrous Dysplasia, Monostotic / surgery. Fibrous Dysplasia, Polyostotic / surgery. Humans. Internal Fixators. Male. Osteotomy / instrumentation. Osteotomy / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 17389820.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates
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29. Ogbureke KU, Nashed MN, Ayoub AF: Huge peripheral osteoma of the mandible: a case report and review of the literature. Pathol Res Pract; 2007;203(3):185-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteomas are rare benign tumors of bone commonly occurring in the maxillofacial skeleton.

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  • (PMID = 17307307.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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30. Inoue N, Izui-Sarumaru T, Murakami Y, Endo Y, Nishimura J, Kurokawa K, Kuwayama M, Shime H, Machii T, Kanakura Y, Meyers G, Wittwer C, Chen Z, Babcock W, Frei-Lahr D, Parker CJ, Kinoshita T: Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood; 2006 Dec 15;108(13):4232-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In both cases, der(12) had a break within the 3' untranslated region of HMGA2, the architectural transcription factor gene deregulated in many benign mesenchymal tumors, that caused ectopic expression of HMGA2 in the bone marrow.
  • These observations suggest that aberrant HMGA2 expression, in concert with mutant PIGA, accounts for clonal hematopoiesis in these 2 patients and suggest the concept of PNH as a benign tumor of the bone marrow.
  • [MeSH-major] Biomarkers, Tumor / genetics. Hematopoiesis / genetics. Hemoglobinuria, Paroxysmal / genetics. Membrane Proteins / deficiency. Mutation. Neoplasms / genetics

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  • (PMID = 16940417.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K23 RR020043
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / phosphatidylinositol glycan-class A protein
  • [Other-IDs] NLM/ PMC1895453
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31. Keser S, Bayar A: Osteochondroma of the talar neck: a rare cause of callosity of the foot dorsum. J Am Podiatr Med Assoc; 2005 May-Jun;95(3):295-7
MedlinePlus Health Information. consumer health - Corns and Calluses.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor.
  • [MeSH-major] Bone Neoplasms / complications. Callosities / etiology. Osteochondroma / complications. Talus

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  • (PMID = 15901820.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Ethmoidal osteoid osteoma with orbital and intracranial extension - a case report. BMC Ear Nose Throat Disord; 2005 Mar 11;5:2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones of appendicular skeleton.
  • Radical excision of the tumor could thus be achieved through a craniofacial approach.
  • CONCLUSION: Although benign and rare, skull base osteoid osteoma can present with neurological deficit due to its mass effect and involvement of vital structures.

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  • (PMID = 15760476.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC555567
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33. Simsek A, Sipahioğlu S, Ataoğlu O, Cila E: Clear cell chondrosarcoma of the proximal femur with intrapelvic extension. Arch Orthop Trauma Surg; 2005 Feb;125(1):66-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell chondrosarcoma is a rare tumor that can be easily confused with benign tumors.
  • The aim of this report is to present a case that is rare, initially diagnosed as aneurysmal bone cyst and then chondroblastoma, and has an interesting extension pattern.
  • A 41-year-old male patient was treated for an apparently benign cystic lesion of the right proximal femur by intralesional excision and bone grafting.
  • The pathological diagnosis was aneurysmal bone cyst.
  • Both tumors were resected with a wide margin on the femoral side and a marginal margin on the intrapelvic side.
  • Again, the pathological diagnosis was chondroblastoma.
  • Clinically and pathologically, clear cell chondrosarcoma may be confused with benign bone tumors.
  • This caused a delay in the final diagnosis of this patient and he received inadequate surgical treatment, leading to a hemipelvectomy.
  • We were unable to find an exact explanation for this finding and postulated that tumor cells might have been seeded into the inner wall of the acetabulum during acetabular preparation of the total hip prosthesis.
  • [MeSH-major] Chondrosarcoma / diagnosis. Femoral Neoplasms / diagnosis. Pelvic Neoplasms / secondary. Sarcoma, Clear Cell / diagnosis

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  • (PMID = 15558292.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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34. Rougraff BT: Bone graft alternatives in the treatment of benign bone tumors. Instr Course Lect; 2005;54:505-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone graft alternatives in the treatment of benign bone tumors.
  • Most bone grafting procedures are done during spinal fusion and to treat patients with skeletal trauma.
  • Very few studies have addressed the bone grafting of skeletal defects after benign bone tumor excision.
  • Contained defects have been treated with autogenous bone grafts, fresh-frozen allografts, freeze-dried allografts, demineralized bone matrix, and ceramic materials.
  • Additionally, bone morphogenetic proteins may provide a future treatment option for bone tumor reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods
  • [MeSH-minor] Bone Substitutes. Ceramics. Humans. Tissue Preservation / methods. Transplantation, Homologous

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  • (PMID = 15948475.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Number-of-references] 30
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35. Geniets C, Vanhoenacker FM, Van de Perre S, Van Dyck P, Gielen J, De Schepper AM, Parizel PM: Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features. JBR-BTR; 2006 Sep-Oct;89(5):266-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features.
  • Benign bone lesions are a fairly common finding in radiology practice.
  • Often, the combination of patient's age and plain radiographic findings are sufficient for diagnosis and obviates the need for further imaging.
  • Generally the following parameters should be assessed in the evaluation of a bone lesion: clinical features, age of the patient, location, size, pattern of bone destruction, cortical involvement, zone of transition, sclerotic margination and matrix calcification.
  • This article reviews the spectrum of clinical and imaging appearances of the most common benign bone tumors.
  • [MeSH-major] Bone Diseases / diagnosis. Bone Neoplasms / diagnosis. Magnetic Resonance Imaging. Radiology. Societies, Medical. Tomography, X-Ray Computed
  • [MeSH-minor] Bone and Bones / pathology. Humans

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  • (PMID = 17147017.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Belgium
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36. Lindfors NC, Heikkilä JT, Koski I, Mattila K, Aho AJ: Bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors. J Biomed Mater Res B Appl Biomater; 2009 Jul;90(1):131-6
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  • [Title] Bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors.
  • In a prospective randomized study, 25 patients with benign bone tumors were surgically treated with either bioactive glass S53P4 (BG) or autogenous bone (AB) as bone graft material.
  • The filled cavity was replaced faster by new bone in the AB group than in the BG group (p = 0.0001).
  • [MeSH-major] Biocompatible Materials. Bone Neoplasms / therapy. Bone Substitutes. Glass
  • [MeSH-minor] Bone Development. Female. Humans. Male. Tomography, X-Ray Computed

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18988277.001).
  • [ISSN] 1552-4981
  • [Journal-full-title] Journal of biomedical materials research. Part B, Applied biomaterials
  • [ISO-abbreviation] J. Biomed. Mater. Res. Part B Appl. Biomater.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes
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37. Guo S, Feng W, Jia Y: [Lyophilized small-segment allogeneic bone in repairing bone defect due to benign bone tumor and tumor-like lesions after resection and curettage]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Aug;21(8):789-92
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  • [Title] [Lyophilized small-segment allogeneic bone in repairing bone defect due to benign bone tumor and tumor-like lesions after resection and curettage].
  • OBJECTIVE: To investigate the clinical application and complication of the lyophilized small-segment allogeneic bone used in repairing bone defects caused by benign bone tumor and tumor-like lesions after resection and curettage.
  • 8 years), who had bone defects caused by benign bone tumors and tumor-like lesions after surgical resection and curettage, were treated by the lyophilized small-segment allogeneic bones.
  • The cavities left by the tumor curettage ranged in size from 1.0 cm x 0.8 cm to 10.0 cm x 2.0 cm, and the bone defects were about 1.0 to 3.5 cm in diameter after the localized resection of the bones.
  • According to the bone defect degrees, the autogenous nonvascular iliac bone and the bone allograft (0.5-30.0 g) were implanted, followed by the drainage for 2-3 days and the use of antibiotics to prevent infection.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone union.
  • RESULTS: There was no significant difference in the allergic reactions, such as postoperative temperature, drained amount, and body swelling, between this kind of transplantation and the autogenous bone transplantation.
  • The follow-up for 6-60 months (average, 38 months) revealed that all the patients had the allograft unions of the bones within 6-18 months after the transplantation, and only 6 patients had recurrence of the tumor (3.0%).
  • CONCLUSION: The lyophilized small-segment allogeneic bone has a good compatibility and osteogenesis, when it is used in repairing bone defects caused by benign bone tumor and tumor-like lesions after resection and curettage.
  • So, this kind of bone is a good, convenient and safe material for the bone transplantation.
  • The important factors affecting the allograft union are as follows: the mechanical stability in the recipient region, local blood supply, and management of the bone cavity left by resection and curettage of the bone tumor.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Ilium / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Cysts / radiography. Bone Cysts / surgery. Child. Child, Preschool. Curettage. Female. Follow-Up Studies. Freeze Drying. Humans. Male. Middle Aged. Postoperative Complications / surgery. Transplantation, Autologous. Transplantation, Homologous. Wound Healing. Young Adult

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  • (PMID = 17882868.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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38. Schnirring-Judge M, Visser J: Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case. J Foot Ankle Surg; 2009 Jul-Aug;48(4):495-505
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case.
  • Osteochondroma, which is also known as exostosis, is the most common benign bone tumor.
  • In this review, we describe the clinical and diagnostic imaging characteristics of benign bone tumors and, in particular, the osteochondroma and its surgical management.
  • [MeSH-major] Bone Neoplasms / surgery. Hallux / surgery. Osteochondroma / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasms, Post-Traumatic / pathology. Young Adult

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  • (PMID = 19577730.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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39. Hirata M, Murata H, Takeshita H, Sakabe T, Tsuji Y, Kubo T: Use of purified beta-tricalcium phosphate for filling defects after curettage of benign bone tumours. Int Orthop; 2006 Dec;30(6):510-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of purified beta-tricalcium phosphate for filling defects after curettage of benign bone tumours.
  • Fifty-three patients with benign bone tumours were treated with curettage and filling with a purified beta-tricalcium phosphate (beta-TCP).
  • Radiographically, complete resorption of the material and bone remodelling were achieved in 23 cases (43%).
  • We concluded that purified beta-TCP was an ideal bone graft substitute for the treatment of benign bone tumours because of its good biocompatibility and resorption characteristics.
  • [MeSH-major] Biocompatible Materials / therapeutic use. Bone Neoplasms / surgery. Calcium Phosphates / therapeutic use

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  • [Cites] J Bone Joint Surg Br. 2000 Nov;82(8):1117-20 [11132269.001]
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  • (PMID = 16736145.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Calcium Phosphates; 0 / beta-tricalcium phosphate
  • [Other-IDs] NLM/ PMC3172745
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40. Abula A, Abaiyedula A, Yusufu A, Liu C, Huang H: [Preliminary clinical application of cancellous granule-type calcium phosphate cement]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Sep;24(9):1100-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate the clinical efficacy of the cancellous granule-type calcium phosphate cement in repair bone defect.
  • METHODS: Between July 2008 and July 2009, 35 patients (42 limbs) with fractures, nonunion, and benign bone tumor were treated with cancellous granule-type calcium phosphate cement.
  • There were 32 males and 3 females, with an age range from 9 to 73 years (median, 41 years), including 24 limb fractures (19 cases), 4 osteotomy for deformity of ulna and radius (2 cases), 2 femur intertrochanteric bony cysts (2 cases), 3 enchondroma (3 cases), 5 bone defect at donor ilium (5 cases), 3 nonunion (3 cases), and 1 lumbar spinal stenosis (1 case).
  • The size of bone defect was 1-5 cm.
  • Bone defect was repaired with cancellous granule-type calcium phosphate cement (1-5 g).
  • Incision dehiscence occurred in 2 cases, and wounds healed after second debridement and removal of artificial bone.
  • X-ray films showed that bone graft fusion was achieved and bone defect was radically repaired at 6 months after operation and artificial bone was absorbed completely at 12 months.
  • CONCLUSION: Cancellous granule-type calcium phosphate cement can be used as a new graft bone material, which is suitable for defect filling after traumatic fracture, benign bone tumors, and iliac bone donor.
  • [MeSH-major] Bone Cements. Bone Transplantation / instrumentation. Calcium Phosphates / therapeutic use

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  • (PMID = 20939483.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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41. Cundy T, Bolland M: Paget disease of bone. Trends Endocrinol Metab; 2008 Sep;19(7):246-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paget disease of bone.
  • Despite significant advances in management, Paget disease remains an enigmatic disorder.
  • There are no animal models, and while its end result --a focal disorder of accelerated bone turnover--is easily recognized, the causes and evolution of the disorder remain uncertain.
  • Most observations seem to fit best with the idea that Paget disease behaves as a multifocal benign neoplasm.

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  • (PMID = 18691901.001).
  • [ISSN] 1043-2760
  • [Journal-full-title] Trends in endocrinology and metabolism: TEM
  • [ISO-abbreviation] Trends Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 53
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42. Wallace MJ, Ross M: Bone lymphangiomatosis: treatment with percutaneous cementoplasty. Spine (Phila Pa 1976); 2005 Jun 15;30(12):E336-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone lymphangiomatosis: treatment with percutaneous cementoplasty.
  • OBJECTIVES: Disseminated lymphangiomatosis is a rare disorder that can produce clinical manifestation secondary to soft tissue, visceral and bone involvement.
  • The overall prognosis of this disorder is usually poor, and the current treatment options for its sequelae are limited and only palliative.
  • In this report, we present the use of cementoplasty in the percutaneous treatment of a sacral lymphangiomatous bone lesion producing severe pain.
  • SUMMARY OF BACKGROUND DATA: Disseminated lymphangiomatosis is a rare disorder that can produce clinical manifestation secondary to soft tissue, visceral, and bone involvement.
  • Computed tomography guided osteoplasty injecting acrylic bone cement into the lesion resulted in almost immediate reduction in pain.
  • The injection of bone cement into the sacral lesion was then monitored by intermittent CT imaging.
  • CONCLUSION: The case presented demonstrates the feasibility and efficacy of computed tomography-guided cementoplasty used to palliate unusual causes of benign osteolytic bone lesions.
  • [MeSH-major] Bone Cements / therapeutic use. Lymphangioma / therapy. Minimally Invasive Surgical Procedures. Orthopedic Procedures / methods. Sacrum / pathology. Spinal Neoplasms / therapy
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Recurrence, Local. Osteolysis / parasitology. Osteolysis / surgery. Tomography, X-Ray Computed

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  • (PMID = 15959357.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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43. O'Malley DP, Kim YS, Perkins SL, Baldridge L, Juliar BE, Orazi A: Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders. Mod Pathol; 2005 Dec;18(12):1550-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders.
  • Extramedullary hematopoiesis seen in non-neoplastic conditions can occasionally be extensive and raise concerns for a myeloid neoplasm.
  • Post-bone marrow transplant and thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome spleens showed extramedullary hematopoiesis with some morphologic features of immaturity, which could simulate chronic myeloproliferative disorder.
  • [MeSH-major] Bone Marrow / pathology. Bone Marrow Neoplasms / pathology. Hematopoiesis, Extramedullary. Myeloproliferative Disorders / pathology. Spleen / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Proliferation. Child. Child, Preschool. Humans. Middle Aged

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  • (PMID = 16118626.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Martel Villagrán J, Bueno Horcajadas A, Ortiz Cruz EJ: [Percutaneous radiofrequency ablation of benign bone tumors: osteoid osteoma, osteoblastoma, and chondroblastoma]. Radiologia; 2009 Nov-Dec;51(6):549-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Percutaneous radiofrequency ablation of benign bone tumors: osteoid osteoma, osteoblastoma, and chondroblastoma].
  • [Transliterated title] Tratamiento mediante radiofrecuencia percutánea de los tumores óseos benignos: osteoma osteoide, osteoblastoma y condroblastoma.
  • We report our experience in the computed tomography (CT)-guided percutaneous radiofrequency ablation of more than 100 benign bone tumors in the last eight years.
  • We affirm that this should be the technique of choice in the vast majority of osteoid osteomas; it can also be applied as a definitive treatment in many cases of osteoblastomas or chondroblastomas as well as in less common benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation. Chondroblastoma / surgery. Osteoblastoma / surgery. Osteoma, Osteoid / surgery

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  • (PMID = 19863982.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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45. Bostan B, Sen C, Gunes T, Erdem M, Koseoglu RD: Osteoid osteoma of the trapezium: case report. J Hand Surg Am; 2010 Apr;35(4):636-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor representing approximately 10% of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Trapezium Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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  • (PMID = 20171814.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Baena-Ocampo Ldel C, Ramirez-Perez E, Linares-Gonzalez LM, Delgado-Chavez R: Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution. Ann Diagn Pathol; 2009 Feb;13(1):16-21
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  • [Title] Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution.
  • A retrospective analysis of all bone tumors accessioned at a large referral center (Instituto Nacional de Rehabilitacion) in Mexico City between 2000 and 2005 is presented.
  • A total of 6216 biopsies and surgical resection specimens were reviewed during this period, of which 566 corresponded to bone tumors.
  • Benign bone tumors accounted for 71.6% of cases and malignant bone tumors for 28.4%.
  • The tumors affected men in 53.7% of cases and women in 46.3% of cases, with an average age at presentation of 25 years.
  • The femur was the most common location of the tumors (39.9%), followed by the tibia (17.7%) and humerus (11.8%).
  • The commonest malignant bone tumors were osteosarcoma (46.6%) and chondrosarcoma (8.7%).
  • Of malignant bone tumors, 18.6% corresponded to metastases of carcinomas from internal organs and 8.1% were multiple myeloma.
  • The most common benign bone tumor was osteochondroma (43.7%) followed by giant cell tumor of bone (14.6%) and enchondroma (10.1%).
  • The age distribution showed a peak in children and adolescents comprised predominantly of benign lesions and a second peak in young adults that corresponded to malignant bone tumors (principally osteosarcoma).
  • Malignant bone tumors most often involved the femur, vertebra, and tibia.
  • Geographic location does not appear to represent a risk factor for any particular type of bone tumor and does not affect the age distribution, location, or histopathologic type of the lesions.
  • [MeSH-major] Bone Neoplasms / epidemiology. Bone Neoplasms / pathology. Chondrosarcoma / epidemiology. Chondrosarcoma / pathology. Osteosarcoma / epidemiology. Osteosarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Chondroma / epidemiology. Chondroma / pathology. Female. Giant Cell Tumors / epidemiology. Giant Cell Tumors / pathology. Giant Cell Tumors / secondary. Humans. Incidence. Infant. Male. Mexico / epidemiology. Middle Aged. Osteochondroma / epidemiology. Osteochondroma / pathology. Referral and Consultation. Retrospective Studies. Risk Factors. Urban Population

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  • (PMID = 19118777.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Bonekamp D, Jacene H, Bartelt D, Aygun N: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med; 2008 Dec;33(12):909-11
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  • Fibrous dysplasia (FD) accounts for 7% of benign bone tumors.
  • It is a developmental disorder of unclear etiology.
  • The lamellar cancellous bone of the medullary cavity is replaced with immature fibroosseous tissue.
  • We describe a case of FD of the skull in a patient of advanced age (69 years) with recent diagnosis of colon cancer, which changed its FDG activity and CT appearance within 10 months of follow-up.
  • [MeSH-major] Fibrous Dysplasia of Bone / radionuclide imaging. Fluorodeoxyglucose F18. Molecular Mimicry. Neoplasm Metastasis / pathology. Positron-Emission Tomography. Skull / pathology. Skull / radionuclide imaging

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  • (PMID = 19033807.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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48. Murata H, Horie N, Matsui T, Akai T, Ueda H, Oshima Y, Konishi E, Kubo T: Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Ann Nucl Med; 2008 Apr;22(3):221-4
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma.
  • Chondromyxoid fibroma (CMF) is a benign bone tumor.
  • However, it is sometimes difficult to distinguish this tumor from chondrosarcoma.
  • The tumor was diagnosed as CMF by open biopsy.
  • It is important that CMF is correctly distinguished from other tumors because this may be histologically overdiagnosed as chondrosarcoma.
  • Contrast-enhanced MR imaging and thallium-201 scintigraphy may be useful to distinguish CMF from benign bone tumors or chondrosarcoma.
  • [MeSH-minor] Adolescent. Biopsy. Citrates / pharmacokinetics. Contrast Media / pharmacokinetics. Diagnosis, Differential. Diphosphonates / pharmacokinetics. Fibroma / radiography. Fibroma / radionuclide imaging. Fibula / pathology. Gadolinium DTPA / pharmacokinetics. Gallium / pharmacokinetics. Humans. Knee Joint / pathology. Knee Joint / radiography. Knee Joint / radionuclide imaging. Knee Joint / surgery. Magnetic Resonance Imaging. Male. Osteolysis / radiography. Radionuclide Imaging. Radiopharmaceuticals / pharmacokinetics. Technetium Compounds / pharmacokinetics

  • Hazardous Substances Data Bank. GALLIUM .
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  • (PMID = 18498038.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Citrates; 0 / Contrast Media; 0 / Diphosphonates; 0 / Radiopharmaceuticals; 0 / Technetium Compounds; 0 / Thallium Radioisotopes; 27905-02-8 / gallium citrate; 8V3FGC4J77 / technetium Tc 99m diphosphonate; CH46OC8YV4 / Gallium; K2I13DR72L / Gadolinium DTPA
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49. Panagopoulos I, Mertens F, Löfvenberg R, Mandahl N: Fusion of the COL1A1 and USP6 genes in a benign bone tumor. Cancer Genet Cytogenet; 2008 Jan 1;180(1):70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fusion of the COL1A1 and USP6 genes in a benign bone tumor.
  • Aneurysmal bone cyst (ABC) is a benign intraskeletal cyst that often expands rapidly and shows a strong tendency to recur.
  • Here we report a second case of a bone tumor carrying a t(17;17) resulting in a COL1A1-USP6 chimeric gene.
  • [MeSH-major] Bone Neoplasms / genetics. Collagen Type I / genetics. Gene Fusion. Proto-Oncogene Proteins / genetics. Tibia. Translocation, Genetic. Ubiquitin Thiolesterase / genetics
  • [MeSH-minor] Adolescent. Chromosomes, Human, Pair 17. Humans. Male. Neoplasm Regression, Spontaneous

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  • (PMID = 18068538.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Proto-Oncogene Proteins; 0 / collagen type I, alpha 1 chain; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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50. Roy S, Dobson P, Henry L: An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone. J Bone Joint Surg Br; 2005 Oct;87(10):1423-4
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  • [Title] An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone.
  • Osteochondroma is the most common benign bone tumour.
  • We report a case of an isolated osteochondroma which appeared benign on clinical and plain radiographic examination but routine histological analysis revealed non-Hodgkin's lymphoma in the underlying bone.
  • This association has not previously been reported and the case emphasises the importance of routine histological analysis, even if a lesion appears benign.
  • [MeSH-major] Bone Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Osteochondroma / pathology

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  • (PMID = 16189321.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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51. Cueva-Del Castillo JF, Valdés-Gutiérrez GA, Elizondo-Vázquez F, Pérez-Ortiz O, Piña Barba MC, León-Mancilla BH: [Bone loss treatment, pseudoarthrosis, arthrodesis and benign tumors using xenoimplant: clinical study]. Cir Cir; 2009 Jul-Aug;77(4):287-91; 267-71
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  • [Title] [Bone loss treatment, pseudoarthrosis, arthrodesis and benign tumors using xenoimplant: clinical study].
  • BACKGROUND: Bone loss as a result of arthrodesis, pseudarthrosis, benign tumors and bone defects was treated using a xenoimplant (Nukbone).
  • Twenty eight patients had arthrodesis, 16 were treated with pseudarthrosis, three patients had benign tumors and five patients presented bone defects, which were implanted with Nukbone at the site and was the correct treatment for the problem.
  • CONCLUSIONS: In Mexico, bony xenoimplants (osseous) have been used, all of foreign origin due to the high degree of technological dependence in this country.
  • In this study we describe the use, for the first time, of a Mexican xenoimplant with a patent from the Universidad Nacional Autónoma de México (UNAM).
  • The Mexican xenoimplant is biocompatible and can be adapted to treat pathologies where bony (osseous) material is needed.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Resorption / surgery. Bone Transplantation. Pseudarthrosis / surgery. Transplantation, Heterologous

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  • (PMID = 19919790.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Mexico
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52. Saikia KC, Bhattacharya TD, Bhuyan SK, Talukdar DJ, Saikia SP, Jitesh P: Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects. Indian J Orthop; 2008 Apr;42(2):169-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects.
  • BACKGROUND: Synthetic bio-inert materials are currently used as an alternative to autogenous bone graft.
  • The purpose of this study is to analyse the use of HA and beta-TCP in their ceramic forms as a bone graft substitute in filling bone voids after curettage of benign bone tumors.
  • MATERIALS AND METHODS: Twenty-four patients in the age range of 3.5-55 years (mean 14.3 years) having benign bone tumors with bone defects were filled with bone graft substitute following curettage.
  • In 20 patients bone defects were filled with block/granules of HA ceramic and in four with beta-TCP.
  • CONCLUSION: Calcium hydroxyapatite and beta-TCP are excellent bone graft substitutes for autogenous bone graft in filling voids after curettage of benign bone tumors.

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  • [Cites] Clin Orthop Relat Res. 1989 Mar;(240):53-62 [2537166.001]
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  • (PMID = 19826522.001).
  • [ISSN] 0019-5413
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2759621
  • [Keywords] NOTNLM ; Benign bone tumor / bone graft substitute / calcium phosphate ceramic / hydroxyapatite
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53. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • The peak incidence of this neoplasm is in the first two decades of life.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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54. Layadi F, Aniba K, Lmejjati M, Aït Elqadi A, Aït Benali S: [Giant osteoid osteoma of the posterior skull base. A case report and literature review]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):128-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Ostéome ostéoïde géant de l'étage postérieur de la base du crâne. A propos d'un cas et revue de la littérature.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones.
  • Cerebral MRI shows a giant lesion of the posterior cerebral fossa with destruction of the left petrous bone and the left side of the occipital bone.
  • CONCLUSION: Although benign and rare, osteoid osteoma can present with neurological deficit due to mass effect and involvement of nervous structures especially in the posterior skull base.

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  • (PMID = 16840973.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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55. Cabrera RA, Almeida M, Mendonça ME, Frable WJ: Diagnostic pitfalls in fine-needle aspiration cytology of temporomandibular chondroblastoma: report of two cases. Diagn Cytopathol; 2006 Jun;34(6):424-9
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroblastoma is a benign bone neoplasm, which usually presents in the epiphysis of long bones, but can occur in unusual locations.
  • This emphasizes the diagnostic pitfalls of this entity and expands the cytologic differential diagnosis of tumors of the parotid region.
  • [MeSH-major] Biopsy, Fine-Needle. Bone Neoplasms / diagnosis. Chondroblastoma / diagnosis. Mandible / pathology. Temporal Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Parotid Neoplasms / pathology. Synovitis, Pigmented Villonodular / pathology

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  • (PMID = 16680777.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Vaz G, Richard A, Guyen O, Bejui-Hugues J, Carret JP: [Desmoplastic fibroma or bone desmoid tumor: two cases]. Rev Chir Orthop Reparatrice Appar Mot; 2005 Dec;91(8):782-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Desmoplastic fibroma or bone desmoid tumor: two cases].
  • [Transliterated title] Le fibrome desmoplastique ou fibrome desmoïde osseux: à propos de 2 nouveaux cas d'une tumeur osseuse rare.
  • Desmoplastic fibroma or desmoid bone tumor is a rare tumor described for the first time by Jaffe in 1958.
  • It accounts for 0.1 to 0.3% of all benign bone tumors.
  • Histology is required for certain diagnosis of desmoplastic fibroma.
  • The tumor is composed of sparse fibroblasts in a rich background of collagen fibers, a histological presentation exactly the same as soft tissue desmoid fibroma.
  • The observations illustrate the radiological diagnosis.
  • MRI was used to search for local extension in bone or soft tissues.
  • Biopsy is necessary to confirm the diagnosis.
  • Surgery is the optimal treatment, with tumor resection as wide as possible depending on the localization.
  • [MeSH-major] Bone Neoplasms. Fibroma, Desmoplastic. Fibromatosis, Aggressive. Pelvic Bones. Tibia

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  • (PMID = 16553001.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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57. Fenichel I, Garniack A, Morag B, Palti R, Salai M: Percutaneous CT-guided curettage of osteoid osteoma with histological confirmation: a retrospective study and review of the literature. Int Orthop; 2006 Apr;30(2):139-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumour usually occurring in young individuals (10-30 years).
  • In the past, surgery was performed in an "open" fashion and the nidus had to be removed with a bone block.
  • The diagnosis was histologically confirmed in 14 cases out of 18 (77%).
  • The use of a cannulated drill and a cannulated curette facilitates efficient removal of the tumour and procurement of tissue for diagnosis.

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  • (PMID = 16474938.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
  • [Other-IDs] NLM/ PMC2532079
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58. Cantwell CP, Scanlon T, Dudeney S, O'Byrne J, Eustace S: CT guided radiofrequency ablation of intra-articular osteoid osteoma of the hip. Ir J Med Sci; 2005 Jul-Sep;174(3):97-9
MedlinePlus Health Information. consumer health - Joint Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteoid osteoma is a painful benign bone tumour.
  • Image guided radiofrequency ablation can be clinically applied to ablate the tumour in a minimally invasive manner.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation. Hip / physiopathology. Joint Diseases / therapy. Osteoma, Osteoid / surgery

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  • (PMID = 16285350.001).
  • [ISSN] 0021-1265
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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59. Tuzuner T, Kavak A, Parlak AH, Ustundag N: Subungual osteochondroma: a diagnostic dilemma. J Am Podiatr Med Assoc; 2006 Mar-Apr;96(2):154-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common skeletal neoplasm of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Nail Diseases / diagnosis. Osteochondroma / diagnosis. Toe Phalanges / pathology

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  • (PMID = 16546954.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Atalar B, Miller RC, Dincbas FO, Geismar JH, Micke O, Akyurek S, Ozyar E: Adult langerhans cell histiocytosis of bones : a rare cancer network study. Acta Orthop Belg; 2010 Oct;76(5):663-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Langerhans Cell Histiocytosis (LCH) is an uncommon benign bone tumour typically seen in children.
  • The localization of tumours was skull bones in 12 (40%), lower extremity in 6 (20%), thoracic bones in 4 (133%), spine in 3 (10%), pelvis in 2 (6.7%) and multiple sites in 3 (10%) patients.
  • [MeSH-major] Bone Diseases / therapy. Histiocytosis, Langerhans-Cell / therapy

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  • (PMID = 21138223.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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61. Abolghasemian M, Rezaie M, Behgoo A, Shoushtarizadeh T, Ghazavi MT: Exostosis-like intra-articular periosteal osteoblastoma: a rare case. Am J Orthop (Belle Mead NJ); 2010 Jun;39(6):E50-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma is a relatively rare benign bone tumor, most often located in the vertebral column or metaphysis of the long bones, particularly the femur and the tibia.
  • Exostosis-like appearance is not common even in periosteal osteoblastoma, a very rare type of this tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Hip Joint / pathology. Osteoblastoma / pathology. Periosteum / pathology

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  • (PMID = 20631934.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Roehl HH, Pacifici M: Shop talk: Sugars, bones, and a disease called multiple hereditary exostoses. Dev Dyn; 2010 Jun;239(6):1901-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Children with the disease form numerous benign bone tumors (osteochondromas) and have >2% chance of developing chondrosarcoma.
  • [MeSH-major] Bone and Bones / pathology. Exostoses, Multiple Hereditary / genetics. Exostoses, Multiple Hereditary / surgery
  • [MeSH-minor] Bone Neoplasms / genetics. Bone Neoplasms / surgery. Boston. Carbohydrates / genetics. Child. Chondrosarcoma / genetics. Heparitin Sulfate / genetics. Humans. Mutation. Osteochondroma / genetics

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  • (PMID = 20503385.001).
  • [ISSN] 1097-0177
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 072346/Z/03/Z
  • [Publication-type] Congresses; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbohydrates; 9050-30-0 / Heparitin Sulfate
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63. Mir NA, Baba AN, Maajid S, Badoo AR, Mir GR: Osteoblastoma of body of the talus--Report of a rare case with atypical radiological features. Foot Ankle Surg; 2010 Jun;16(2):e24-6
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  • Osteoblastoma is a benign bone tumour found commonly in the spine and long tubular bones.
  • Analysis of clinical, radiological and histological findings confirmed the diagnosis of osteoblastoma.
  • [MeSH-major] Bone Neoplasms / radiography. Osteoblastoma / radiography. Rare Diseases. Talus. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Osteotomy / methods

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483122.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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64. Lanza A, Laino L, Rossiello L, Perillo L, Ermo AD, Cirillo N: Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction. Open Dent J; 2008;2:73-7
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  • [Title] Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction.
  • Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph.
  • Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distinguishing benign tumours from their malign counterpart, although the radiographic aspect of the lesion is not always predictive.
  • Therefore a critical differential diagnosis has to be reached to choose the best management.
  • Here, we report a case of giant cell tumour (GCT) whose radiological features by computed tomography (CT) suggested the presence of bone malignancy, whereas the evaluation of a routine OPT scan comforted us about the benign nature of the lesion.
  • A brief review of the literature on such a benign but locally aggressive neoplasm is also provided.

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  • [Cites] Acta Otorhinolaryngol Ital. 2004 Feb;24(1):26-9 [15270430.001]
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  • (PMID = 19088886.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2581533
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65. Obalum DC, Eyesan SU, Ezembakwe ME, Abdulkareem FB: Pattern of osteochondromas in Lagos, Nigeria. Nig Q J Hosp Med; 2008 Apr-Jun;18(2):69-71

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  • Osteochondromas are the most common benign tumours of bone.

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  • (PMID = 19068555.001).
  • [ISSN] 0189-2657
  • [Journal-full-title] Nigerian quarterly journal of hospital medicine
  • [ISO-abbreviation] Nig Q J Hosp Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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66. Kumar A, Varshney MK, Trikha V, Rastogi S: An unusual presentation of a rare chest wall tumour: giant cell tumour of bone. Joint Bone Spine; 2007 Jan;74(1):100-2
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  • [Title] An unusual presentation of a rare chest wall tumour: giant cell tumour of bone.
  • Giant cell tumour of bone is an aggressive benign bone tumour.
  • We report a case of giant cell tumour of the anterior end of the rib masquerading as a sub-mammary abscess in lactating women.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Thoracic Wall
  • [MeSH-minor] Abscess / diagnosis. Adult. Diagnosis, Differential. Female. Humans. Lactation. Treatment Outcome

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  • (PMID = 17197221.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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67. Dämmrich TD, Knapp FB, Boedeker CC, Klenzner T, Berlis A, Maier W, Schipper J: [Craniofacial fibrous dysplasia: scan policy or surgery?]. Laryngorhinootologie; 2007 Mar;86(3):184-92
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  • The criteria of the decision for diagnosis and surgical procedures were evaluated.
  • RESULTS: According to the literature, diagnosis was ascertained with modern CT and MRI scans.
  • Bone scintigraphy was only used additionally in particular questions.
  • In case of unclear radiological findings histomorphological procedures were used complementarily to distinguish FD from other bone tumors.
  • CONCLUSIONS: Current imaging procedures allow differential diagnosis from other benign bone tumors but also from malignancies.
  • In the future molecular biological methods could function as supporting instrument for diagnosis if histomorphological results are not meaningful.
  • [MeSH-major] Facial Bones. Fibrous Dysplasia of Bone. Frontal Bone. Skull Base
  • [MeSH-minor] Adult. Computer-Aided Design. Diagnosis, Differential. Female. Follow-Up Studies. Forecasting. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Middle Aged. Prosthesis Design. Retrospective Studies. Surgery, Computer-Assisted. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17131258.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 41
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68. Gibbs CP, Lewis VO, Peabody T: Beyond bone grafting: techniques in the surgical management of benign bone tumors. Instr Course Lect; 2005;54:497-503
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Beyond bone grafting: techniques in the surgical management of benign bone tumors.
  • The traditional surgical treatment of benign bone tumors has been curettage and autologous bone graft or marginal resection of expendable bones.
  • Recently, however, surgeons have been evaluating the results of treatments using limited surgical approaches, including percutaneous treatments, alternatives to autograft bone, and thermal or cytotoxic adjuvant therapies.
  • This process has been facilitated by the availability of multiple bone grafting materials and substitutes, the use of cross-sectional imaging, and technology such as that used with radiofrequency ablation.
  • Techniques using these therapies in two benign bone tumor models are described.
  • The use of percutaneous radiofrequency ablation, now used for both benign and malignant disease, is reviewed as a surgical alternative for osteoid osteoma.
  • The role of adjuvant therapies such as liquid nitrogen and phenol, as well as the indications for resection, are described in the management of giant cell tumors of bone.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Giant Cell Tumor of Bone / surgery. Osteoma, Osteoid / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Bone Transplantation / methods. Humans. Prosthesis Implantation / methods

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  • (PMID = 15948474.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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69. Blackwell JB, Curnow MN: Benign bone tumours in Western Australia, 1972-1996. Pathology; 2007 Dec;39(6):567-74
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  • [Title] Benign bone tumours in Western Australia, 1972-1996.
  • AIMS: To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types.
  • RESULTS: During the 25 year period, 849 benign tumours were accessioned and incidence rates have been calculated for 86 chondromas, 68 osteoid osteomas, 47 giant cell tumours, 32 chondroblastomas, 15 periosteal chondromas and 13 chondromyxoid fibromas.
  • CONCLUSION: The BTR provides a valuable resource for the study of primary bone tumours.
  • This review has established reliable incidence rates for the six most common benign tumours.
  • Such information is rarely available for benign tumours.
  • [MeSH-major] Bone Neoplasms / pathology. Registries
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Western Australia / epidemiology

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  • (PMID = 18027260.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • [Title] Tumors for the general orthopedist: how to save your patients and practice.
  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Matsumoto Y, Okada Y, Fukushi J, Kamura S, Fujiwara T, Iida K, Koga M, Matsuda S, Harimaya K, Sakamoto A, Iwamoto Y: Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone. J Orthop Surg Res; 2010;5:85
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  • [Title] Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone.
  • BACKGROUND: Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs).
  • Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumor cells, while monocyte-like cells and MNCs are reactive osteoclast precursor cells (OPCs) and osteoclasts (OCs), respectively.
  • In this study, we investigated the pathogenesis of osteoclastic bone destruction in GCTs by focusing on the role of the vascular endothelial growth factor (VEGF)-Flt-1 (type-1 VEGF receptor)-focal adhesion kinase (FAK) pathway.
  • CONCLUSIONS: Our results suggest that the VEGF-Flt-1-FAK pathway is involved in the pathogenesis of bone destruction of GCTs.


77. Kim JP, Seo JB, Kim MH, Yoo MJ, Min BK, Moon SY: Osteochondroma associated with complete rupture of the distal biceps tendon: case report. J Hand Surg Am; 2010 Aug;35(8):1340-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondromas are the most common benign bone tumors.
  • [MeSH-major] Bone Neoplasms / complications. Osteochondroma / complications. Radius. Tendon Injuries / etiology

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  • [Copyright] Copyright 2010 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20684931.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Matysiakiewicz J, Tomasik P, Miszczyk L, Spindel J, Widuchowski J, Koczy B, Chrobok A, Mrozek T: Manifestations, diagnosis and surgical treatment of enchondroma--own experience. Ortop Traumatol Rehabil; 2010 Mar-Apr;12(2):155-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Manifestations, diagnosis and surgical treatment of enchondroma--own experience.
  • BACKGROUND: An enchondroma is a rather common benign tumour of bone that originates from cartilage.The course is usually benign but they have a tendency to recur and are sometimes invasive, especially when developing in long bones.
  • RESULTS: The tumours were mostly located in phalanges of the fingers--55 cases (37%), and metacarpal bones--21 cases (14%).
  • A total of 170 surgical procedures were performed, mostly (120 procedures) tumour resections with bone graft implantation.
  • CONCLUSION: Total resection of the enchondroma combined with spongy bone grafting is the main treatment of chondroma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Chondroma / diagnosis. Chondroma / surgery

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  • (PMID = 20453254.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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79. Hassankhani EG: Solitary lower lumbar osteochondroma (spinous process of L3 involvement): a case report. Cases J; 2009;2:9359

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Solitary osteochondromas, which are the most common benign bone tumors of long bones, are rarely found in the vertebral column.
  • The tumor was excised en bloc through a posterior approach and histopathological examination verified the diagnosis of osteocondroma.Osteochondromas are rarely found in the spine, when present in the spine, however, have a predilection for cervical or upper thoracic region arising usually from lamina of vertebrae and are rare in lumbosacral region and very rare at spinous process of the vertebrae.We present a case of osteochondroma locates in lumbar region and spinous process of vertebrae with unusual presentation and was considered clinically as congenital lumbar kyphosis.

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  • [ISO-abbreviation] Cases J
  • [Language] eng
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80. Al Shaikhi A, Hébert-Davies J, Moser T, Maillot E, Danino AM: Osteoid osteoma of the capitate: a case report and literature review. Eplasty; 2009;9:e38

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor that rarely affects the carpal bones.
  • We report an unusual case of osteoid osteoma in the capitate where the diagnosis was delayed and the presentation was that of an aggressive natured lesion with considerable functional incapacitation.
  • Diagnosis was made by computed tomographic scan of the wrist and surgical excision lead to a dramatic relief of symptoms.

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  • (PMID = 19823564.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2744766
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81. Fraquet N, Faizon G, Rosset P, Phillipeau J-, Waast D, Gouin F: Long bones giant cells tumors: treatment by curretage and cavity filling cementation. Orthop Traumatol Surg Res; 2009 Oct;95(6):402-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long bones giant cells tumors: treatment by curretage and cavity filling cementation.
  • OBJECTIVE: Giant cell tumors (GCT) of bone are benign tumors with local aggressiveness that most of the time occur around the metaphyseal area of long bones, often in contact with the articular cartilage.
  • Twenty-six of these tumors were present around the knee: 14 at the distal femur and 12 at the proximal tibia.
  • Preoperative radiological evaluation with standard X-rays showed that the tumor measured a mean 71x45mm, for a mean volume of 78cm(3).
  • Two cases of minor osteoarthritis progression were noted (one less than 50% and a simple densification of subchondral bone), requiring no specific treatment.
  • Diagnosis of recurrence can be made earlier because of the thin scalable border at the bone-cement interface.
  • [MeSH-major] Bone Cements / therapeutic use. Bone Neoplasms / surgery. Femur / surgery. Giant Cell Tumor of Bone / surgery. Orthopedic Procedures / methods. Tibia / surgery

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19767256.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Cements
  • [General-notes] NLM/ Original DateCompleted: 20100201
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82. Heck RK, Pope WD, Ahn JI, Smith RA, Webber BL: Histologic evaluation of the depth of necrosis produced by argon beam coagulation: implications for use as adjuvant treatment of bone tumors. J Surg Orthop Adv; 2009;18(2):69-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologic evaluation of the depth of necrosis produced by argon beam coagulation: implications for use as adjuvant treatment of bone tumors.
  • Argon beam coagulation (ABC) has been advocated as adjuvant treatment after curettage of aggressive benign bone tumors.
  • This study was done to evaluate the depth of necrosis in cancellous bone treated with ABC.
  • A 6-month-old pig was sacrificed and 20 1.5-cm cortical windows were created in the metaphyseal areas of the humeri, femora, and tibiae, exposing the underlying cancellous bone.
  • [MeSH-major] Bone Neoplasms / surgery. Bone and Bones / pathology. Laser Coagulation / instrumentation. Lasers, Excimer / therapeutic use

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  • (PMID = 19602333.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Jansson AF, Müller TH, Gliera L, Ankerst DP, Wintergerst U, Belohradsky BH, Jansson V: Clinical score for nonbacterial osteitis in children and adults. Arthritis Rheum; 2009 Apr;60(4):1152-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To accurately differentiate nonbacterial osteitis (NBO) from other bone lesions by applying a clinical score through the use of validated diagnostic criteria.
  • Two hundred twenty-four patients older than age 3 years who had either NBO (n = 102), proven bacterial osteomyelitis (n = 22), malignant bone tumors (n = 48), or benign bone tumors (n = 52) were identified by chart review.
  • Univariate logistic regression was used to determine associations of single risk factors with a diagnosis of NBO, and multivariable logistic regression was used to assess simultaneous risk factor associations with NBO.
  • RESULTS: NBO was best predicted by a normal blood cell count (odds ratio [OR] 81.5), symmetric bone lesions (OR 30.0), lesions with marginal sclerosis (OR 26.8), normal body temperature (OR 20.3) a vertebral, clavicular, or sternal location of lesions (OR 13.9), presence of >1 radiologically proven lesion (OR 10.9), and C-reactive protein level > or =1 mg/dl (OR 6.9).
  • The clinical score for a diagnosis of NBO based on these predictors ranged from 0 to 63.
  • [MeSH-major] Osteitis / diagnosis. Osteitis / epidemiology
  • [MeSH-minor] Adult. Bacterial Infections / diagnosis. Bacterial Infections / epidemiology. Blood Cell Count. Bone Neoplasms / diagnosis. Bone Neoplasms / epidemiology. Child. Child, Preschool. Decision Trees. Diagnosis, Differential. Female. Histiocytosis, Langerhans-Cell / diagnosis. Histiocytosis, Langerhans-Cell / epidemiology. Humans. International Classification of Diseases. Logistic Models. Male. Osteosarcoma / diagnosis. Osteosarcoma / epidemiology. Predictive Value of Tests. Retrospective Studies. Risk Factors. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / epidemiology. Sensitivity and Specificity

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  • (PMID = 19333943.001).
  • [ISSN] 0004-3591
  • [Journal-full-title] Arthritis and rheumatism
  • [ISO-abbreviation] Arthritis Rheum.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Yoo WH, Kim JR, Jang KY, Lee SY, Park JH: Rapidly developed huge bursitis associated with scapular osteochondroma of the multiple exostosis: a case report. Rheumatol Int; 2009 Jan;29(3):317-9
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  • Osteochondroma is the most common benign bone tumor and present as multiple masses in the hereditary disorder of multiple hereditary exostosis.

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  • [Cites] Am J Clin Pathol. 1981 May;75(5):648-53 [7234751.001]
  • [Cites] Skeletal Radiol. 1991;20(7):513-6 [1754913.001]
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  • (PMID = 18682954.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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85. Futani H, Fukunaga S, Nishio S, Yagi M, Yoshiya S: Successful treatment of bilateral calcaneal intraosseous lipomas using endoscopically assisted tumor resection. Anticancer Res; 2007 Nov-Dec;27(6C):4311-4
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  • [Title] Successful treatment of bilateral calcaneal intraosseous lipomas using endoscopically assisted tumor resection.
  • BACKGROUND: Intraosseous lipoma is a rare benign bone tumor.
  • Curettage was performed through small bone fenestrations in the medial and lateral aspects under observation with a 2.7-mm-diameter Hopkins telescope.
  • The bone void was filled with beta-tricalcium phosphate (beta-TCP).
  • CONCLUSION: Endoscopically assisted curettage is feasible in patients with benign bone tumors of the calcanei to avoid a long period of non-weightbearing post-operatively.
  • [MeSH-major] Bone Neoplasms / surgery. Calcaneus / surgery. Curettage / methods. Endoscopy. Lipoma / surgery

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  • (PMID = 18214037.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Calcium Phosphates; 0 / beta-tricalcium phosphate
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86. Chen YR, Chang CN, Tan YC: Craniofacial fibrous dysplasia: an update. Chang Gung Med J; 2006 Nov-Dec;29(6):543-9
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  • Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue.
  • It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton.

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  • (PMID = 17302216.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 50
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87. Edwards PC, Fantasia JE, Saini T, Rosenberg TJ, Sachs SA, Ruggiero S: Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Dec;102(6):765-72
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  • BACKGROUND: Neurofibromatosis 1 (NF1) is an autosomal dominantly inherited disorder caused by a spectrum of mutations affecting the Nf1 gene.
  • Affected patients develop benign and malignant tumors at an increased frequency.
  • Clinical findings include multiple cutaneous café-au-lait pigmentations, neurofibromas, axillary freckling, optic gliomas, benign iris hamartomas (Lisch nodules), scoliosis, and poorly defined soft tissue lesions of the skeleton.
  • While the presence of CGCGs of the jaws in patients with NF1 could represent either a coincidental association or a true genetic linkage, we propose that this phenomenon is most likely related to NF1-mediated osseous dysplasia.
  • Compared to normal bone, the Nf1-haploinsufficient bone in a patient with NF1 may be less able to remodel in response to as of yet unidentified stimuli (e.g. excessive mechanical stress and/or vascular fragility), and consequently may be more susceptible to developing CGCG-like lesions.
  • Alternatively, the CGCG in NF1 patients could represent a true neoplasm, resulting from additional, as of yet unidentified, genetic alterations to Nf1-haploinsufficient bone.

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  • (PMID = 17138179.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Finstein JL, Hosalkar HS, Ogilvie CM, Lackman RD: Case reports: an unusual complication of radiofrequency ablation treatment of osteoid osteoma. Clin Orthop Relat Res; 2006 Jul;448:248-51
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  • Osteoid osteoma is a benign bone tumor traditionally treated nonoperatively or by operative excision.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / adverse effects. Osteoma, Osteoid / surgery. Skin / pathology. Skin Diseases / etiology. Tibia

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  • [CommentIn] Clin Orthop Relat Res. 2006 Oct;451:290-1; author reply 291-2 [16906101.001]
  • [CommentIn] Clin Orthop Relat Res. 2007 Jul;460:285; author reply 285-6 [17534193.001]
  • (PMID = 16826123.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA: Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J; 2006;26:69-76
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  • [Title] Ethanol as a local adjuvant for giant cell tumor of bone.
  • Giant cell tumor is an aggressive benign neoplasm of bone.
  • No report on its use in a group of patients with giant cell tumor is available.
  • Records were retrospectively reviewed for all giant cell tumors treated by intralesional curettage and high concentration ethanol irrigation as the only chemical adjuvant.
  • Twenty-five primary excisional curettages and 12 repeat curettages for giant cell tumors of bone were performed in 31 patients.
  • [MeSH-major] Bone Neoplasms / therapy. Ethanol / therapeutic use. Giant Cell Tumor of Bone / therapy

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  • (PMID = 16789453.001).
  • [ISSN] 1541-5457
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
  • [Other-IDs] NLM/ PMC1888590
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90. Brastianos P, Pradilla G, McCarthy E, Gokaslan ZL: Solitary thoracic osteochondroma: case report and review of the literature. Neurosurgery; 2005 Jun;56(6):E1379; discussion E1379
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  • OBJECTIVE AND IMPORTANCE: Osteochondromas are common benign bone tumors that rarely arise in the vertebral column.
  • Intraspinal presentation of these tumors is usually circumscribed to the cervical regions with few tumors presenting in the thoracic vertebrae.
  • CONCLUSION: Our case is atypical in that the tumor arose from the posterior portion of the T12 body, causing spinal cord dysfunction that necessitated an anterior approach to T12 for corpectomy with thoracolumbar fixation and fusion.

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  • (PMID = 15918958.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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91. Park JW, Namkoong S, Chung J, Jung KE, Oh SA, Cinn YW, Kim MH: A case of eccrine spiradenoma in a patient with neurofibromatosis. Ann Dermatol; 2010 May;22(2):191-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system and skin.
  • Some benign or malignant tumors such as juvenile xanthogranuloma, pheochromocytoma, and malignant melanoma can accompany neurofibromatosis.
  • Eccrine spiradenoma is a benign uncommon neoplasm of skin adnexa.

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  • [Cites] Arch Dermatol. 1990 Aug;126(8):1051-6 [2166484.001]
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  • (PMID = 20548911.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883423
  • [Keywords] NOTNLM ; Eccrine spiradenoma / Neurofibromatosis
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92. Aalderink K, Wolf B: Scapular osteochondroma treated with arthroscopic excision using prone positioning. Am J Orthop (Belle Mead NJ); 2010 Feb;39(2):E11-4
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondromas, or exostoses, are common benign bone tumors.
  • [MeSH-major] Arthroscopy / methods. Bone Neoplasms / pathology. Osteochondroma / pathology. Scapula / pathology

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  • (PMID = 20396684.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Liedauer R, Svoboda M, Wlcek K, Arrich F, Jä W, Toma C, Thalhammer T: Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. Oncol Rep; 2009 Dec;22(6):1485-92
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  • [Title] Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts.
  • OATP expression had been shown in different tissues, but not in bone tumors.
  • Therefore, the expression pattern of all known eleven human OATPs was analyzed by quantitative RT-PCR in 21 human bone tumor specimens (osteosarcomas, bone metastases and benign aneurysmal bone cysts).
  • Transcriptional expression of OATP1A2, 1C1, 2A1, 2B1, 3A1, 4A1, 4C1 and 5A1, but not of OATP1B1, 1B3 and 6A1 was observed in malignant and non-malignant tumor specimens at varying level.
  • Importantly, OATP3A1, 4A1, 2B1 and 1C1 mRNA levels were significantly higher in aneurysmal bone cysts as compared to osteosarcomas.
  • Elevated mRNA levels of OATP2A1, 1A2, and 4C1 in metastases from kidney cancer and of OATP5A1 in prostate cancer suggest that the OATP expression pattern in metastases is comparable to that of the primary tumors.
  • Different to tissue, OATP expression in osteosarcoma cell lines HOS and MG-63, normal human osteoblast outgrowth cells (hOB) and bone marrow stromal cells (BMSC) is limited to OATP3A1 and OATP4A1.
  • High OATP expression levels, particularly in benign bone tumors, suggest an important role of these transporters for providing hormones, their conjugates, prostaglandins and drugs in bone cells.
  • Thereby, they may influence bone resorption and formation.
  • [MeSH-major] Bone Cysts, Aneurysmal / metabolism. Bone Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Organic Anion Transporters / metabolism. Osteosarcoma / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Resorption. Cell Line, Tumor. Child. Female. Gene Expression Profiling. Humans. Male. Middle Aged. Neoplasm Metastasis. Transcription, Genetic

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  • (PMID = 19885603.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Organic Anion Transporters
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94. Bischoff M, Bischoff G, Buck A, von Baer A, Pauls S, Scheffold F, Schultheiss M, Gebhard F, Reske SN: Integrated FDG-PET-CT: its role in the assessment of bone and soft tissue tumors. Arch Orthop Trauma Surg; 2010 Jul;130(7):819-27
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  • [Title] Integrated FDG-PET-CT: its role in the assessment of bone and soft tissue tumors.
  • PURPOSE: The purpose of this study was to evaluate prospectively, whether integrated 2-deoxy-2-[(18)F]fluoro-D: -glucose positron emission tomography-computed tomography (FDG-PET-CT) is more accurate for determination musculoskeletal tumors compared with separate interpretation of CT and FDG-PET, because most of the current clinical data come from patients studied with PET.
  • METHODS: Eighty patients with newly diagnosed musculoskeletal tumors underwent FDG-PET-CT.
  • RESULTS: Assuming that equivocal lesions are benign, performance of diagnostic tests was as follows: sensitivity, specificity and accuracy for CT alone was 81, 84, 83%, for PET 71, 82, 76, and for PET-CT 80, 83 and 86%.
  • CONCLUSIONS: Combined FDG-PET-CT reliably differentiates soft tissue and bone tumors from benign lesions.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fluorodeoxyglucose F18. Muscle Neoplasms / diagnosis. Positron-Emission Tomography. Radiopharmaceuticals. Soft Tissue Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • [CommentIn] Arch Orthop Trauma Surg. 2012 Aug;132(8):1217-8 [22643802.001]
  • (PMID = 19636577.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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95. Thomas DM, Skubitz KM: Giant cell tumour of bone. Curr Opin Oncol; 2009 Jul;21(4):338-44
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  • [Title] Giant cell tumour of bone.
  • PURPOSE OF REVIEW: Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / therapy. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / therapy

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  • (PMID = 19444102.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / RANK Ligand; 0 / TNFSF11 protein, human; 4EQZ6YO2HI / Denosumab
  • [Number-of-references] 60
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96. Futani H, Okumura Y, Fukuda Y, Fukunaga S, Hasegawa S, Yoshiya S: Giant cell tumor of the sternum: a case report and review of the literature. Anticancer Res; 2008 Nov-Dec;28(6B):4117-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the sternum: a case report and review of the literature.
  • Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor.
  • Extended curettage of the tumor was performed followed by polymethylmethacrylate (PMMA) filing.
  • In conclusion, even though sternal benign tumors are rare, GCT should be considered as one of the differential diagnoses in a patient presenting with a sternal lesion in the 5th or 6th decade of life.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Sternum / pathology
  • [MeSH-minor] Bone Cements. Female. Humans. Middle Aged. Polymethyl Methacrylate. Reconstructive Surgical Procedures / methods

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  • (PMID = 19192670.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Bone Cements; 9011-14-7 / Polymethyl Methacrylate
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97. Toma CD, Svoboda M, Arrich F, Ekmekcioglu C, Assadian O, Thalhammer T: Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. J Pineal Res; 2007 Sep;43(2):206-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors.
  • The beneficial effects of melatonin on bone homeostasis have been shown in various diseases.
  • As this indoleamine causes dose-dependent modulation of bone-forming osteoblast and bone-resorbing osteoclast activities by receptor-independent and -dependent pathways, we investigated the expression of G-protein-coupled melatonin receptors (MTs) in malignant and non-malignant human bone lesions.
  • By TaqMan polymerase chain reaction (PCR), we analyzed 30 specimens from osteosarcoma and 11 from benign bone tumors for MT1-mRNA expression.
  • Although mean MT1-mRNA levels were similar (P = 0.596) in malignant (4.39 +/- 4.98-fold) and benign samples (4.64 +/- 6.81-fold), the highest MT1-mRNA levels (up to 27-fold) were observed in individual osteosarcomas, particularly, in two specimens of patients with local recurrence of the tumor.
  • Moreover, mean RANKL- and OPG-mRNA levels were similar in malignant and benign specimens (RANKL: 7.38 +/- 9.61-fold versus 3.57 +/- 3.11-fold, P = 0.207; OPG: 23.45 +/- 32.76 versus 8.07 +/- 7.23-fold, P = 0.133).
  • High expression levels of MT1-mRNA together with low OPG-mRNA were found in both osteosarcoma cell lines, while in normal human osteoblasts and bone marrow stromal cells, high OPG-mRNA levels were associated with low MT1-mRNA levels.
  • These data on the abundant expression of MT1-mRNA in human bone tumors and osteosarcoma cells lines suggest an important role for MT1 in bone pathology.
  • [MeSH-major] Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Gene Expression Regulation, Neoplastic. Receptor, Melatonin, MT1 / metabolism

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  • (PMID = 17645699.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Osteoprotegerin; 0 / RANK Ligand; 0 / RNA, Messenger; 0 / Receptor, Melatonin, MT1
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98. Tanigawa N, Kariya S, Kojima H, Komemushi A, Fujii H, Sawada S: Lower limb ischaemia caused by fractured osteochondroma of the femur. Br J Radiol; 2007 Apr;80(952):e78-80
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  • Osteochondroma is the most common benign bone tumour and can arise in any bone.
  • [MeSH-major] Bone Neoplasms / complications. Exostoses, Multiple Hereditary / complications. Femoral Fractures / complications. Ischemia / etiology. Leg / blood supply

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  • (PMID = 17551166.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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99. Kawakami Y, Kunisada T, Sugihara S, Ono A, Nishida K, Abe N, Kawai A, Fujiwara K, Morimoto Y, Ozaki T: New approach for assessing vascular distribution within bone tumors using dynamic contrast-enhanced MRI. J Cancer Res Clin Oncol; 2007 Oct;133(10):697-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New approach for assessing vascular distribution within bone tumors using dynamic contrast-enhanced MRI.
  • PURPOSE: To differentiate benign from malignant bone tumors by analyzing the vascular distribution within bone tumors with dynamic contrast-enhanced MRI.
  • METHODS: We studied dynamic contrast-enhanced MRI for 49 bone tumors (22 malignant and 27 benign tumors).
  • Seven small regions of interest (ROI) were set inside the largest portion of each tumor.
  • Four ROI were placed evenly on the periphery and three ROI were placed evenly on the line of the longest breadth within the tumor.
  • The slope of the curve (%Slope) was calculated on the time-intensity curves of the whole tumor and of each ROI.
  • The variance values for the %Slope of the ROI were calculated to assess the dispersion of the intensity change at each ROI within the tumor.
  • RESULTS: Mean value of the %Slopes of whole tumor regions for malignant bone tumors (70.4 +/- 60.3%) was significantly higher than that for benign bone tumors (37.6 +/- 52.9%) (P = 0.015), although giant cell tumor (GCT), a locally aggressive tumor, had a relatively higher %Slope.
  • Mean value of the variance of %Slopes for malignant bone tumors (3485.9 +/- 5942.5) was significantly higher than that for all benign tumors (470.4 +/- 583.9) (P = 0.012), indicating that the %Slope values of seven ROI within malignant bone tumors varied more widely compared with the ROI inside benign bone tumors.
  • CONCLUSION: Our method of analyzing the signal intensity change at seven separate regions that evaluates the vascular distribution within a tumor could be a useful tool for differentiating between benign and malignant bone tumors.
  • [MeSH-major] Bone Neoplasms / blood supply. Bone Neoplasms / pathology. Magnetic Resonance Imaging

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  • (PMID = 17534662.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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100. Marioni G, Marchese-Ragona R, Guarda-Nardini L, Stramare R, Tognazza E, Marino F, Staffieri A: Giant cell tumour (central giant cell lesion) of the maxilla. Acta Otolaryngol; 2006 Jul;126(7):779-81

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  • [Title] Giant cell tumour (central giant cell lesion) of the maxilla.
  • The giant cell tumour (GCT) is a benign, locally invasive lesion that accounts for about 20% of benign bone tumours.
  • Our successful maxillary reconstruction based on the association between autologous calvarial bone sticks bent with titanium miniplates and a temporalis muscle pedicled flap allowed the involvement of only one donor area for both hard and soft tissues.
  • [MeSH-major] Giant Cell Tumor of Bone / diagnosis. Giant Cell Tumor of Bone / surgery. Maxillary Neoplasms / diagnosis. Maxillary Neoplasms / surgery

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  • (PMID = 16803721.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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