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Items 1 to 100 of about 397
1. Fu K, Meng ZB, Li J, Li HC: [Repairing the defect of benign bone tumor with the coralline hydroxyapatite]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 May;33(5):421-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Repairing the defect of benign bone tumor with the coralline hydroxyapatite].
  • OBJECTIVE: To observe the clinical effect of repairing bone defectin post-operation benign tumor with coralline hydroxyapatite(CHAP).
  • The CHAP was implanted into the lesion after bone tumor curettage to 25 patients.
  • The sizes of bone defect ranged from 0.8 cm x 0.5 cm x 0.5 cm to 10 cm x 3.5 cm x 2 cm.
  • X-ray showed that there was osteogenesis at the cortical bone 1 month post-operation.
  • There is corresponding synchronization between bone formation with CHAP biodegradation.
  • The CHAP is an excellent bone defect repairing material.
  • [MeSH-major] Bone Neoplasms / surgery. Ceramics. Giant Cell Tumor of Bone / surgery. Hydroxyapatites. Prostheses and Implants
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Regeneration. Bone Substitutes. Child. Female. Femur / surgery. Humans. Male. Middle Aged

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  • (PMID = 18544846.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / coralline hydroxyapatite
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2. Manjunatha BS, Nagarajappa D: Osteoid osteoma. Indian J Dent Res; 2009 Oct-Dec;20(4):514-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign tumor of the bone which arises from osteoblasts and is extremely rare in jaws.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Fibroma, Ossifying / diagnosis. Humans. Mandibular Diseases / diagnosis. Osteitis / diagnosis. Osteoblastoma / diagnosis

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  • (PMID = 20139585.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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3. Stănescu L, Popescu CF, Niculescu CE, Dumitrescu D, Mogoantă SS, Georgescu I: Subungual exostosis of the big toe. Rom J Morphol Embryol; 2009;50(3):501-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The subungual exostosis is a benign bone tumor on the distal phalanx of a digit, beneath or adjacent to the nail, often bringing in discussion many differential diagnosis.
  • In the present, the radiological findings of the affected finger and the histopathological ones from the fragment excised confirmed the diagnosis of subungual exostosis.

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  • (PMID = 19690782.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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4. Daghfous M, Charfi H, Turki M, Maalla R, Baccari S, Tarhouni L: [Chondromyxoid fibroma. A case report of location in the phalanx of the thumb]. Chir Main; 2007 Jun;26(3):159-64
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  • Chondromyxoid Fibroma is a rare benign osseous tumor especially in the hand, because the hand represents less than 3% of all osseous locations.
  • It can causes problems of differential diagnosis with several types of tumors and in particular with chondrosarcoma, for which the management is totally different.
  • We report a case of location of a chondromyxoid fibroma in a phalanx of the thumb, which caused problems of differential diagnosis with chondroma and chondrosarcoma.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroblastoma / pathology. Fibroma / pathology. Thumb / pathology

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  • (PMID = 17590372.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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5. Angiero F, Mellone P, Baldi A, Stefani M: Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo; 2006 Sep-Oct;20(5):665-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma is a benign bone tumor of osteoblastic origin.
  • Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy.
  • Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed.
  • [MeSH-major] Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 17091775.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. Liu H, Sun J, Wang Y, Yang X, Zhu E: [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Nov;22(11):1349-53
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  • [Title] [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow].
  • OBJECTIVE: To investigate the clinical application of grafting with bioactive glass (BG) and autologous bone marrow for defect after resection and curettage of benign bone neoplasm.
  • METHODS: From January 2004 to May 2007, 34 patients with bone defects were repaired.
  • There were 14 cases of simple bone cysts, 6 cases of fibrous dysplasia, 3 cases of osteoid osteoma, 4 cases of non-ossifying fibroma, 2 cases of enchondroma and 3 cases of giant cell tumor of bone.
  • Tumor sizes varied from 2.0 cm x 1.5 cm x 1.0 cm to 9.0 cm x 3.0 cm x 2.5 cm.
  • Benign bone neoplasm was removed thoroughly with a curet or osteotome, bone defects ranged from 3.0 cm x 2.0 cm x 1.5 cm to 11.0 cm x 3.5 cm x 3.0 cm, which was closed-up with the mixtures of BG and autogenous red bone marrow.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone healing.
  • At averaged 16 weeks after operation, patients with bone tumor in lower limbs resumed walking independently and those with bone tumor in upper limbs resumed holding object.
  • There was no tumor recurrence during follow-up.
  • Radiographically, the interface between the implanted bone and host bone became fuzzy 1 month after implantation.
  • Two months after operation, the BG was absorbed gradually, new bone formation could be seen in the defects.
  • Four months after operation, implanted bone and host bone merged together, bone density increased.
  • Six to ten months after operation, the majority of the implanted BG was absorbed and substituted for new bone, bone remodeling was established.
  • CONCLUSION: BG may boast both bone conductive and bone inductive activities.
  • The combined grafting with BG and autologous bone marrow appears to be minimally invasive treatment to repair bone defects of benign bone neoplasm, with rare complications and no significant reverse reaction, and could repair bone defects completely.
  • [MeSH-major] Bone Marrow Transplantation. Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Bone and Bones / pathology. Child. Female. Follow-Up Studies. Glass. Humans. Male. Middle Aged. Transplantation, Autologous

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  • (PMID = 19068605.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes
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7. Fukunaga S, Futani H, Yoshiya S: Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome. World J Surg Oncol; 2007;5:37
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  • BACKGROUND: Osteochondroma is the most common benign bone tumor in the scapula.
  • Removal of the tumor was performed by the use of endoscopically assisted resection.
  • The tumor was resected in a piece-by-piece manner by the use of graspers through the same portal.
  • CT images showed complete tumor resection.
  • [MeSH-major] Bone Neoplasms / surgery. Endoscopy. Osteochondroma / surgery. Scapula

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  • [Cites] Arch Phys Med Rehabil. 1997 May;78(5):506-11 [9161370.001]
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  • (PMID = 17378939.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1839090
  • [General-notes] NLM/ Original DateCompleted: 20070726
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8. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Tamai N, Myoui A, Kudawara I, Ueda T, Yoshikawa H: Novel fully interconnected porous hydroxyapatite ceramic in surgical treatment of benign bone tumor. J Orthop Sci; 2010 Jul;15(4):560-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Novel fully interconnected porous hydroxyapatite ceramic in surgical treatment of benign bone tumor.
  • BACKGROUND: Large bone defects remaining after curettage of benign bone tumors should be filled with a substitute to restore mechanical strength.
  • In 2000, we developed a fully interconnected porous calcium hydroxyapatite ceramic (IPCHA, NEOBONE) and have utilized it as a bone substitute.
  • The large interconnecting channels (average diameter 40 microm) permit easy penetration of tissue into the deep pores, so IP-CHA can itself induce local bone repair processes.
  • The purpose of this study was to evaluate the clinical outcomes with the use of IP-CHA as bone substitute after curettage of benign bone tumors.
  • METHODS: We reviewed the results of 71 patients with benign bone tumors sequentially treated by curettage followed by implantation of IP-CHA between 2000 and 2006.
  • Radiographic findings were classified into five stages: stage 0, no change; stage 1, slight bone formation; stage 2, moderate bone formation; stage 3, consolidation; stage 4, absorption.
  • However, there were 10 local recurrences, which is similar to the recurrence rate for such tumors treated with or without implantation of CHAs and reflects the biological nature of each tumor.
  • CONCLUSIONS: In this study, we utilized IP-CHA as a bone substitute after curettage of benign bone tumors and demonstrated its usefulness in the clinical situation.
  • IP-CHA comparatively exhibited excellent bone formation at an early stage although the problem of recurrence of the tumor remained.
  • We conclude that IP-CHA is a useful bone substitute for the treatment of benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Ceramics / therapeutic use. Durapatite / therapeutic use. Osteogenesis
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Substitutes / therapeutic use. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20721726.001).
  • [ISSN] 1436-2023
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bone Substitutes; 91D9GV0Z28 / Durapatite
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10. Li J, Wang ZQ, Zhang YM, Song HP, Yuan L: [Application of allogeneic bone in surgical treatment of benign bone neoplasm]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jul;26(7):987-90
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  • [Title] [Application of allogeneic bone in surgical treatment of benign bone neoplasm].
  • OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone.
  • METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft.
  • RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation.
  • The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery.
  • CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods

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  • (PMID = 16864094.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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11. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • PURPOSE: Emerging technologies allow surgeons to diagnose and treat osseous neoplasms while minimizing the collateral damage caused by surgical exposure and tumor excision.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • METHODS: Stereotactic imaging and intraoperative guidance was used as an adjunct to tumor care in these patients.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Güneş D, Mutafoğlu-Uysal K, Sarialioğlu F, Cakmakçi H, Olgun N: Aneurysmal bone cyst of rib presenting as a huge chest wall mass. Turk J Pediatr; 2009 Jan-Feb;51(1):82-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aneurysmal bone cyst of rib presenting as a huge chest wall mass.
  • Aneurysmal bone cyst is a rare benign tumor of the bone that can be difficult to distinguish from malignant tumors, especially when it presents in an unusual location.
  • Herein, we report a six-year-old girl with a primary aneurysmal bone cyst in an uncommon location.
  • She was successfully treated with total excision of tumor without any complication.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Ribs. Thoracic Wall / pathology

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  • (PMID = 19378899.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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13. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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14. Chakrapani SD, Grim K, Kaimaktchiev V, Anderson JC: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976); 2008 Dec 1;33(25):E968-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY OF BACKGROUND DATA: Osteoblastoma is a rare benign tumor of bone that is known to incite a localized inflammatory response.
  • These inflammatory features can simulate malignant behavior on MRI and can lead to misdiagnosis and unnecessarily aggressive resection unless one recognizes the classic benign features on CT.
  • RESULTS: A 9-year-old girl with back pain receives an MRI of the lumbar spine demonstrating a sacral tumor with potentially malignant features including extensive marrow edema and enhancement.
  • A CT demonstrates a well-circumscribed lesion without lytic changes or malignant bone formation.
  • A benign lesion was favored given the CT features and conservative resection was performed.
  • Final pathologic diagnosis was osteoblastoma.
  • CONCLUSION: This case illustrates that the MRI findings for osteoblastoma can be misleading and caution should be used when evaluating benign tumors with known inflammatory responses on MRI.
  • CT features seem to more accurately reflect the true nature and extent of the tumor.
  • [MeSH-major] Magnetic Resonance Imaging. Osteoblastoma / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Inflammation / diagnosis. Inflammation / radiography. Inflammation / surgery. Lumbar Vertebrae / pathology. Lumbar Vertebrae / radiography. Lumbar Vertebrae / surgery

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  • (PMID = 19050575.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Pans S, Brys R, Van Breuseghem I, Geusens E: Benign bone tumours of the spine. JBR-BTR; 2005 Jan-Feb;88(1):31-7
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  • [Title] Benign bone tumours of the spine.
  • A wide variety of primary bone tumours can involve the spine.
  • We present an overview of the primary benign bone tumours of the spine.
  • [MeSH-major] Magnetic Resonance Imaging. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Spinal Diseases / diagnosis

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  • (PMID = 15792167.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 16
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16. Carter T, Flik K, Boland P, Kennedy JG: Iliac hematoma mimicking neoplasm in adolescent athletes. Orthopedics; 2008 Nov;31(11):1144
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Iliac hematoma mimicking neoplasm in adolescent athletes.
  • However, the presentation of such injuries can at times be clinically indistinguishable from the onset of a benign or malignant neoplastic process.
  • This article presents the cases of 2 adolescent boys with traumatic injuries to the hip, in which the threat of neoplasm could not be ruled out by in both initial imaging studies.
  • The authors recommend a diagnostic algorithm to approach the differentiation of iliac hematoma from neoplasm and address the issue of waiting time in the diagnostic process.
  • Early-and if necessary repeated-biopsy to rule out these conditions is advised, as conclusive pathologic findings are the only evidence that can rule out Ewing's sarcoma or an aneurysmal bone cyst.
  • Careful observation in combination with radiographic findings can yield a successful diagnosis, but the orthopedic surgeon must carefully weigh the increased risk of tumor growth against the need for biopsy.
  • [MeSH-major] Athletic Injuries / diagnosis. Bone Neoplasms / diagnosis. Hematoma / diagnosis. Hip Injuries / diagnosis. Ilium / pathology
  • [MeSH-minor] Adolescent. Algorithms. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 19226079.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Shimizu N, Sakata K, Yamamoto I: Benign osteoblastoma of the temporal bone: Case report and review of the literature. Surg Neurol; 2006 Nov;66(5):534-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign osteoblastoma of the temporal bone: Case report and review of the literature.
  • BACKGROUND: Benign osteoblastoma arising from the temporal bone is extremely rare in elderly patients.
  • We reviewed the literature on benign osteoblastoma of the temporal bone and now propose a new classification of this pathologic entity based on its anatomical location in the temporal bone.
  • Preoperative computed tomography showed a bony destructive isodensity mass with calcified component involving the temporal bone.
  • After preoperative embolization on the day before surgery, the patient underwent tumor removal via a left infratemporal approach under neuronavigated guidance.
  • The pathologic examination revealed a benign osteoblastoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoblastoma / diagnosis. Temporal Bone / pathology. Temporal Bone / radiography
  • [MeSH-minor] Aged. Embolization, Therapeutic. Female. Fluorodeoxyglucose F18. Hearing Loss / etiology. Humans. Intraoperative Complications / prevention & control. Neoplasm, Residual. Neuronavigation. Neurosurgical Procedures. Positron-Emission Tomography. Postoperative Hemorrhage / prevention & control. Tinnitus / etiology. Treatment Outcome

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  • (PMID = 17084206.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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18. Thomas EO, Gordon J, Smith-Thomas S, Cramer SF: Diffuse uterine leiomyomatosis with uterine rupture and benign metastatic lesions of the bone. Obstet Gynecol; 2007 Feb;109(2 Pt2):528-30
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  • [Title] Diffuse uterine leiomyomatosis with uterine rupture and benign metastatic lesions of the bone.
  • BACKGROUND: We report a case of diffuse uterine leiomyomatosis in pregnancy complicated by uterine rupture and dissemination to the bone.
  • A free-air series performed postoperatively to confirm paralytic ileus revealed multiple lytic bone lesions.
  • The diagnosis of diffuse uterine leiomyomatosis with metastasis was made on histology of the resected uterus and fine-needle aspiration biopsy of the bone.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fetal Death. Leiomyomatosis / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Prenatal Diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cesarean Section. Diagnosis, Differential. Female. Humans. Hysterectomy. Neoplasm Metastasis. Pregnancy. Pregnancy Trimester, First. Tomography, X-Ray Computed. Uterine Rupture

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  • (PMID = 17267884.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Strobel K, Exner UE, Stumpe KD, Hany TF, Bode B, Mende K, Veit-Haibach P, von Schulthess GK, Hodler J: The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT. Eur J Nucl Med Mol Imaging; 2008 Nov;35(11):2000-8
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  • [Title] The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT.
  • OBJECTIVE: To evaluate the value of a dedicated interpretation of the CT images in the differential diagnosis of benign vs. malignant primary bone lesions with 18 fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT).
  • MATERIALS AND METHODS: In 50 consecutive patients (21 women, 29 men, mean age 36.9, age range 11-72) with suspected primary bone neoplasm conventional radiographs and 18F-FDG-PET/CT were performed.
  • Differentiation of benign and malignant lesions was separately performed on conventional radiographs, PET alone (PET), and PET/CT with specific evaluation of the CT part.
  • RESULTS: According to the standard of reference, conventional 17 lesions were benign and 33 malignant.
  • Median SUV(max) was 3.5 for benign lesions (range 1.6-8.0) and 5.7 (range 0.8-41.7) for malignant lesions.
  • In eight patients with bone lesions with high FDG-uptake (SUV(max) >or= 2.5) dedicated CT interpretation led to the correct diagnosis of a benign lesion (three fibrous dysplasias, two osteomyelitis, one aneurysmatic bone cyst, one fibrous cortical defect, 1 phosphaturic mesenchymal tumor).
  • In four patients with lesions with low FDG-uptake (SUV(max) < 2.5) dedicated CT interpretation led to the correct diagnosis of a malignant lesion (three chondrosarcomas and one leiomyosarcoma).
  • Combined PET/CT was significantly more accurate in the differentiation of benign and malignant lesions than PET alone (p = .039).
  • CONCLUSION: Dedicated interpretation of the CT part significantly improved the performance of FDG-PET/CT in differentiation of benign and malignant primary bone lesions compared to PET alone.
  • PET/CT more commonly differentiated benign from malignant primary bone lesions compared with conventional radiographs, but this difference was not significant.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone and Bones / pathology. Fluorodeoxyglucose F18. Image Processing, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Positron-Emission Tomography

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  • (PMID = 18712385.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
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20. Yanagawa T, Watanabe H, Shinozaki T, Takagishi K: Curettage of benign bone tumors without grafts gives sufficient bone strength. Acta Orthop; 2009 Feb;80(1):9-13
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  • [Title] Curettage of benign bone tumors without grafts gives sufficient bone strength.
  • BACKGROUND AND PURPOSE: The defect that results after curettage of a bone tumor is usually filled in the same way.
  • We report the outcome in patients with benign bone tumors that were treated with curettage but no filling.
  • PATIENTS AND METHODS: We retrospectively studied 78 patients (mean age at the time of operation was 27 (6-73) years, 44 men) who had had a benign bone tumor curetted with no filling of the defect.
  • The commonest tumor types were giant cell tumor of bone (27), fibrous dysplasia (13), enchondroma (9), and simple bone cyst (7).
  • Local recurrence occurred in 9 patients; 7 of them had a giant cell tumor.
  • INTERPRETATION: Routine filling of curetted bone lesions does not appear to be necessary from a mechanical point of view.
  • [MeSH-major] Bone Neoplasms / surgery. Curettage / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Remodeling / physiology. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19234882.001).
  • [ISSN] 1745-3682
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Other-IDs] NLM/ PMC2823236
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21. Li Y, Liang Q, Wen YQ, Chen LL, Wang LT, Liu YL, Luo CQ, Liang HZ, Li MT, Li Z: Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. Cancer Genet Cytogenet; 2010 Apr 15;198(2):97-106
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative proteomics analysis of human osteosarcomas and benign tumor of bone.
  • Proteins extracted from osteosarcoma tissue and benign bone tumors, including osteoblastoma, chondroblastoma, and giant cell tumor of bone, were examined using two-dimensional gel electrophoresis followed by mass spectrometry analysis and database searches.
  • Aberrant expression of cytoskeletal- and microtubule-associated proteins in osteosarcoma may provide an advantage for tumor invasion and metastasis by affecting the stability of microtubule, which consequently influences the prognosis of patients.
  • [MeSH-major] Bone Neoplasms / metabolism. Neoplasm Proteins / analysis. Osteoblastoma / metabolism. Osteosarcoma / metabolism. Proteomics / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Bone and Bones / metabolism. Bone and Bones / pathology. Child. Chondroblastoma / metabolism. Chondroblastoma / pathology. Female. Giant Cell Tumor of Bone / metabolism. Giant Cell Tumor of Bone / pathology. Humans. Male. Middle Aged. Proteome / analysis. Proteome / metabolism. Young Adult


22. Taleb C, Gouzou S, Mantovani G, Liverneaux P: Treatment of benign bone tumours of the hand using osteoscopy. Chir Main; 2010 Apr;29(2):78-81
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  • [Title] Treatment of benign bone tumours of the hand using osteoscopy.
  • Curettage and bone grafting are used traditionally to treat benign bone tumours of the hand.
  • This is a report on three benign metacarpal bone tumours treated with three different endoscopic approaches: multiportal, extended uniportal and oblique uniportal.
  • In theory, the multiportal approach has several drawbacks: weakening of the bone cortex, a limited visual field and seepage of injectable phosphocalcic cement.
  • The oblique uniportal approach seems less troublesome; vision of the bone cavity is good, curettage of the tumour is complete, the bone cortex is undamaged and there is no leakage of injectable phosphocalcic cement.
  • All things considered, the oblique osteoscopic uniportal approach seems to be the best option for the management of benign bone tumours of the hand.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Curettage / methods. Endoscopy / methods. Metacarpal Bones
  • [MeSH-minor] Adult. Bone Cements / therapeutic use. Bone Diseases, Developmental / surgery. Chondroma / surgery. Clinical Protocols. Female. Fluoroscopy. Humans. Male. Neoplasm Recurrence, Local / prevention & control. Treatment Outcome

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20153235.001).
  • [ISSN] 1769-6666
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Cements
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23. Ito Y, Higashiyama T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A: Long-term follow-up for patients with papillary thyroid carcinoma treated as benign nodules. Anticancer Res; 2007 Mar-Apr;27(2):1039-43
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  • [Title] Long-term follow-up for patients with papillary thyroid carcinoma treated as benign nodules.
  • BACKGROUND: The recent prevalence of ultrasonography and fine-needle aspiration biopsy (FNAB) has facilitated the detection and diagnosis of papillary thyroid carcinoma.
  • However, there are still cases that are preoperatively misdiagnosed and treated as benign nodules because ultrasonographic and FNAB findings do not provide sufficient evidence for a malignant diagnosis.
  • PATIENTS AND METHODS: We investigated the prognoses of 56 patients with papillary carcinoma who underwent thyroidectomy without node dissection under a diagnosis of benign nodules.
  • RESULTS: None of the patients underwent further surgery such as completion total thyroidectomy and node dissection after the pathological diagnosis of papillary carcinoma was established.
  • Two patients showed recurrence in the remnant thyroid and one showed recurrence in the bone.
  • CONCLUSION: Papillary carcinomas misdiagnosed as benign nodules on ultrasonography and FNAB are indolent and very slow-growing.
  • Immediate further surgery is not needed for such cases, even if they were resected as benign nodules at the initial surgery.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery. Thyroid Nodule / diagnosis. Thyroid Nodule / surgery
  • [MeSH-minor] Adult. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Diagnostic Errors. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis. Thyroidectomy

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  • (PMID = 17465240.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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24. Ahrens WA, Ridenour RV 3rd, Caron BL, Miller DV, Folpe AL: GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms. Hum Pathol; 2008 Oct;39(10):1519-26
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  • [Title] GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms.
  • GLUT-1, an erythrocyte-type glucose transporter protein expressed in juvenile hemangiomas, has recently been shown to be a sensitive marker of perineurial cells and their tumors in a small number of cases.
  • Prompted by a recent report of GLUT-1 expression in epithelioid sarcoma, a tumor not generally felt to show perineurial differentiation, we examined GLUT-1 expression in a wide variety of mesenchymal tumors.
  • Sections from 247 mesenchymal tumors of a variety of histologic subtypes were retrieved from our archives and immunostained for GLUT-1 using heat-induced epitope retrieval and the DAKO ADVANCE detection system (DAKO, Carpinteria, CA).
  • All benign nerve sheath tumors showed a peripheral rim of positive normal perineurial cells, with 2 neurofibromas and 3 schwannomas showing more extensive staining.
  • GLUT-1 expression was also seen in a wide variety of benign and malignant mesenchymal tumors.
  • However, GLUT-1 expression was absent in nonjuvenile hemangioma endothelial tumors and in almost all low-grade lesions that enter the histologic differential diagnosis of perineurial tumors, including low-grade fibromyxoid sarcoma, dermatofibrosarcoma protuberans, and myxofibrosarcoma.
  • We conclude that GLUT-1 expression in mesenchymal tumors is by no means specific for perineurial differentiation, but may instead represent upregulation of this protein within hypoxic zones, secondary to upstream activation of proteins such as hypoxia-inducible factor 1-alpha.
  • [MeSH-major] Bone Neoplasms / metabolism. Glucose Transporter Type 1 / metabolism. Mesenchymoma / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Count. Humans. Immunohistochemistry. Neoplasm Proteins / metabolism

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  • (PMID = 18620729.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / Neoplasm Proteins
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25. Altay M, Bayrakci K, Yildiz Y, Erekul S, Saglik Y: Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients. J Orthop Sci; 2007 Sep;12(5):415-23
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  • [Title] Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients.
  • BACKGROUND: Secondary malignancies arising from benign bone tumors are rare.
  • Their recognition and diagnosis are difficult, and their slow growth and late recurrence require long-term follow-up.
  • In this study, malignant transformation rates of various histological types of benign cartilage-forming bone tumors in large series were evaluated.
  • METHODS: Between 1986 and 2004, a retrospective analysis of 627 cartilage-forming benign bone tumors revealed that 32 patients had malignant transformation.
  • RESULTS: The rate of malignant transformation for cartilage-originating tumors was 5.1% (solitary osteochondromas 4.2%, multiple osteochondromas 9.2%, solitary enchondromas 4.2%).
  • The average time between the initial diagnosis and malignant transformation was 9.8 years.
  • The tumors generally were well differentiated.
  • Five patients (15.6%) died of tumor recurrence or metastasis at an average of 20.6 months.
  • One patient is alive with tumor at 104 months.
  • CONCLUSIONS: Cartilage-forming benign bone tumors are rather prone to undergo malignant transformation.
  • Although malignant transformation of a benign bone tumor is a rarely encountered situation, orthopedic surgeons should be cautious while following patients with a benign bone neoplasm.
  • [MeSH-major] Bone Neoplasms / pathology. Cartilage / pathology. Chondrosarcoma / secondary. Neoplasms, Second Primary / pathology. Osteochondroma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Transformation, Neoplastic / pathology. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 17909925.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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26. Jordan E, Choe D, Miller T, Chamarthy M, Brook A, Freeman LM: Utility of bone scintigraphy to determine the appropriate vertebral augmentation levels. Clin Nucl Med; 2010 Sep;35(9):687-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Utility of bone scintigraphy to determine the appropriate vertebral augmentation levels.
  • However, diagnosis and localization of the causative vertebral level(s) may be difficult using any single imaging modality.
  • In this retrospective study, we assessed the ability of preprocedural bone scans to determine the appropriate level(s) of subsequent vertebroplasty.
  • MATERIALS AND METHODS: The study consisted of a retrospective chart review of 44 patients who underwent bone scintigraphs and vertebroplasties at Montefiore Medical Center from 2002 to 2008.
  • Online medical records and reports were used to determine the level of vertebroplasty and the preprocedure bone scan levels.
  • RESULTS AND CONCLUSIONS: Our retrospective study assessed the utility of bone scans as a diagnostic tool to identify candidate vertebral levels for vertebroplasty and determined that bone scans were positive in 78.3% of all fractures that subsequently underwent vertebral augmentation procedures.
  • Although no significant difference was seen in the positivity of bone scans to subsequent vertebroplasty levels between benign or metastatic compression fractures (79% vs. 76%), a difference was observed when single level vertebroplasty patients were compared with multiple-level vertebroplasty patients (87% vs. 69%).
  • Our results support the use of whole body bone scintigraphy as a diagnostic tool prior to vertebroplasty, especially in cases where a single vertebral level is involved or MRI might be contraindicated.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Neoplasm Metastasis. Osteoporosis / radionuclide imaging. Osteoporosis / surgery. Spinal Fractures / radionuclide imaging. Spinal Fractures / surgery. Spinal Neoplasms / radionuclide imaging. Spinal Neoplasms / surgery. Whole-Body Irradiation

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  • (PMID = 20706042.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Haque AU, Moatasim A: Giant cell tumor of bone: a neoplasm or a reactive condition? Int J Clin Exp Pathol; 2008;1(6):489-501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of bone: a neoplasm or a reactive condition?
  • Giant cell tumor of bone (GCTB) is a benign but locally aggressive bone tumor of young adults.
  • However such findings are not universal and can be seen in rapidly proliferating normal cells as well as in several osseous lesions of developmental and/or reactive nature, and the true neoplastic nature of GCTB remains controversial.
  • Malignancy usually does not occur in GCTB and when discover, it usually represents primary bone sarcomas missed at original diagnosis.
  • Aneurysmal bone cyst (ABC) shares many features with GCTB.
  • There had been unique karyotypic changes in some aneurysmal bone cysts making it distinct from GCTB.

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  • (PMID = 18787633.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480584
  • [Keywords] NOTNLM ; Giant cell tumor / aneurysmal bone cyst / bone / bone matrix / hemorrhage / osteoclast / osteoclastoma / telomerase
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28. Cabrera RA, Almeida M, Mendonça ME, Frable WJ: Diagnostic pitfalls in fine-needle aspiration cytology of temporomandibular chondroblastoma: report of two cases. Diagn Cytopathol; 2006 Jun;34(6):424-9
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroblastoma is a benign bone neoplasm, which usually presents in the epiphysis of long bones, but can occur in unusual locations.
  • This emphasizes the diagnostic pitfalls of this entity and expands the cytologic differential diagnosis of tumors of the parotid region.
  • [MeSH-major] Biopsy, Fine-Needle. Bone Neoplasms / diagnosis. Chondroblastoma / diagnosis. Mandible / pathology. Temporal Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Parotid Neoplasms / pathology. Synovitis, Pigmented Villonodular / pathology

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  • (PMID = 16680777.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Sampol Bas C, Peña Viloria C, Giménez García M: [Solitary hypermetabolic bone focus in the initial extension study of a prostate carcinoma]. Rev Esp Med Nucl; 2005 Nov-Dec;24(6):414-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Solitary hypermetabolic bone focus in the initial extension study of a prostate carcinoma].
  • [Transliterated title] Foco óseo hipermetabólico único en el estudio de extensión inicial de un carcinoma de próstata.
  • 56 year old male who was diagnosed of Prostatic Neoplasm by transrectal biopsy after elevated PSA level was found by chance in a routine control.
  • This was followed by a whole body bone scintigraphy with 99mTc-MDP that showed a solitary hypermetabolic lesion within skull.
  • An MRI and a CT head scan were carried out to characterize the isotopic lesion, finding no bone abnormalities to justify the mentioned uptake.
  • Given the absence of a radiological benign diagnosis, a further FDG-PET scan was carried out which did not show either increased glycolytic activity at the left occipital region, or in the prostatic gland.
  • In order to guide the biopsy, a CT head scan was repeated which showed what appeared to be an incipient blastic lesion in the scale of the left occipital bone, establishing the differential diagnosis between a metastasis and a benign process.
  • The anatomopathologic analysis of the bone tissue describes a necrotic process without inflammatory reaction (osteonecrosis).
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Occipital Bone / radionuclide imaging. Osteonecrosis / radionuclide imaging. Prostatic Neoplasms / radionuclide imaging
  • [MeSH-minor] Biomarkers, Tumor / blood. Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Diagnosis, Differential. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Proteins / blood. Positron-Emission Tomography. Prostate-Specific Antigen / blood. Radiopharmaceuticals / pharmacokinetics. Skull Neoplasms / radionuclide imaging. Skull Neoplasms / secondary. Technetium Tc 99m Medronate / pharmacokinetics. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 16324519.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Radiopharmaceuticals; EC 3.4.21.77 / Prostate-Specific Antigen; X89XV46R07 / Technetium Tc 99m Medronate
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30. Rougraff BT: Bone graft alternatives in the treatment of benign bone tumors. Instr Course Lect; 2005;54:505-12
MedlinePlus Health Information. consumer health - Bone Grafts.

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  • [Title] Bone graft alternatives in the treatment of benign bone tumors.
  • Most bone grafting procedures are done during spinal fusion and to treat patients with skeletal trauma.
  • Very few studies have addressed the bone grafting of skeletal defects after benign bone tumor excision.
  • Contained defects have been treated with autogenous bone grafts, fresh-frozen allografts, freeze-dried allografts, demineralized bone matrix, and ceramic materials.
  • Additionally, bone morphogenetic proteins may provide a future treatment option for bone tumor reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods
  • [MeSH-minor] Bone Substitutes. Ceramics. Humans. Tissue Preservation / methods. Transplantation, Homologous

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  • (PMID = 15948475.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Number-of-references] 30
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31. Gebert C, Brinkschmidt C, Bielack S, Bernhardt T, Jürgens H, Böcker W, Winkelmann W, Bürger H, Gosheger G: The potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions. Int J Surg Pathol; 2006 Jul;14(3):187-92
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions.
  • Matrix-producing bone lesions consist of a wide variety of benign and malignant conditions.
  • With respect to morphology, an overlap exists between benign and malignant bone tumors that causes difficulties in the final determination of the tumor.
  • This study was conducted to show the potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions.
  • Thirty benign bone tumors were evaluated by conventional comparative genomic hybridization.
  • In contrast benign tumors or tumor-like lesions did not reveal any chromosomal alterations.
  • Comparative genomic hybridization is a useful adjunct in the complicated differential diagnostic algorithms of matrix-producing bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chromosome Aberrations. DNA, Neoplasm / genetics. Molecular Diagnostic Techniques / methods. Osteosarcoma / diagnosis

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  • (PMID = 16959697.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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32. Bostan B, Sen C, Gunes T, Erdem M, Koseoglu RD: Osteoid osteoma of the trapezium: case report. J Hand Surg Am; 2010 Apr;35(4):636-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor representing approximately 10% of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Trapezium Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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  • (PMID = 20171814.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Zissimopoulos A, Stellos K, Matthaios D, Petrakis G, Parmenopoulou V, Babatsikou F, Matthaiou E, Theodosiadou E, Hountis P, Koutis C: Type I collagen biomarkers in the diagnosis of bone metastases in breast cancer, lung cancer, urinary bladder cancer and prostate cancer. Comparison to CEA, CA 15-3, PSA and bone scintigraphy. J BUON; 2009 Jul-Sep;14(3):463-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Type I collagen biomarkers in the diagnosis of bone metastases in breast cancer, lung cancer, urinary bladder cancer and prostate cancer. Comparison to CEA, CA 15-3, PSA and bone scintigraphy.
  • PURPOSE: In this study we evaluated the clinical usefulness of serum pro-I collagen peptide (PICP) and I collagen telopeptide (ICTP) as indicators of early bone metastases in patients with breast (BC), lung (LC), urinary bladder (UBC) and prostate cancer (PC).
  • 145 had histologically confirmed BC (92 with bone metastases), 20 UBC (6 with bone metastases), 11 LC (3 with bone metastases) and 129 PC (68 with bone metastases).
  • In BC patients we compared the PICP and ICTP levels with those of CA 15-3, CEA and bone scintigraphy.
  • Patients with LC and UBC had PICP and ICTP measurements, PC patients had serum PICP, prostate specific antigen (PSA) measurements and bone scans.
  • RESULTS: ICTP and CA 15-3 levels were significantly higher in patients with BC and bone metastases in comparison to patients without metastases (p <0.05), while PICP and CEA were only marginally higher.
  • Significant correlation was observed between existence of bone metastases and ICTP levels (p <0.05).
  • ICTP and CA 15-3 were the most reliable markers for early diagnosis of bone metastases in BC.
  • Furthermore, PICP and PSA levels were significantly higher in patients with PC and bone metastases in comparison to patients with benign prostate hyperplasia (BPH) (p <0.0001) or in patients with PC without bone metastases (p <0.0005 for PICP and p <0.0001 for PSA).
  • In LC patients, ICTP levels differed significantly between patients with and without bone metastases (p=0.025).
  • In UBC patients, PICP levels differed significantly between patients with and without bone metastases (p=0.017).
  • CONCLUSION: ICTP and CA 15-3 are the most reliable markers for early diagnosis of bone metastases in BC patients.
  • PICP could be useful for diagnosing early bone metastases of PC and combined with PSA and bone scan can be an additional tool in the follow-up of PC patients.
  • For LC patients, ICTP showed a significant difference in the discrimination of patients with and without bone metastases.
  • In UBC patients, PICP showed a significant difference in the discrimination of patients with and without bone metastases.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Collagen Type I / metabolism
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / pathology. Carcinoembryonic Antigen / metabolism. Female. Humans. Immunoradiometric Assay. Lung Neoplasms / pathology. Male. Middle Aged. Mucin-1 / metabolism. Neoplasm Metastasis. Prostate-Specific Antigen / metabolism. Prostatic Neoplasms / pathology. Sensitivity and Specificity. Tomography, Emission-Computed. Urinary Bladder Neoplasms / pathology


34. Bonekamp D, Jacene H, Bartelt D, Aygun N: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med; 2008 Dec;33(12):909-11
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  • Fibrous dysplasia (FD) accounts for 7% of benign bone tumors.
  • It is a developmental disorder of unclear etiology.
  • The lamellar cancellous bone of the medullary cavity is replaced with immature fibroosseous tissue.
  • We describe a case of FD of the skull in a patient of advanced age (69 years) with recent diagnosis of colon cancer, which changed its FDG activity and CT appearance within 10 months of follow-up.
  • [MeSH-major] Fibrous Dysplasia of Bone / radionuclide imaging. Fluorodeoxyglucose F18. Molecular Mimicry. Neoplasm Metastasis / pathology. Positron-Emission Tomography. Skull / pathology. Skull / radionuclide imaging

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  • (PMID = 19033807.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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35. Murata H, Horie N, Matsui T, Akai T, Ueda H, Oshima Y, Konishi E, Kubo T: Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Ann Nucl Med; 2008 Apr;22(3):221-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma.
  • Chondromyxoid fibroma (CMF) is a benign bone tumor.
  • However, it is sometimes difficult to distinguish this tumor from chondrosarcoma.
  • The tumor was diagnosed as CMF by open biopsy.
  • It is important that CMF is correctly distinguished from other tumors because this may be histologically overdiagnosed as chondrosarcoma.
  • Contrast-enhanced MR imaging and thallium-201 scintigraphy may be useful to distinguish CMF from benign bone tumors or chondrosarcoma.
  • [MeSH-minor] Adolescent. Biopsy. Citrates / pharmacokinetics. Contrast Media / pharmacokinetics. Diagnosis, Differential. Diphosphonates / pharmacokinetics. Fibroma / radiography. Fibroma / radionuclide imaging. Fibula / pathology. Gadolinium DTPA / pharmacokinetics. Gallium / pharmacokinetics. Humans. Knee Joint / pathology. Knee Joint / radiography. Knee Joint / radionuclide imaging. Knee Joint / surgery. Magnetic Resonance Imaging. Male. Osteolysis / radiography. Radionuclide Imaging. Radiopharmaceuticals / pharmacokinetics. Technetium Compounds / pharmacokinetics

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  • (PMID = 18498038.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Citrates; 0 / Contrast Media; 0 / Diphosphonates; 0 / Radiopharmaceuticals; 0 / Technetium Compounds; 0 / Thallium Radioisotopes; 27905-02-8 / gallium citrate; 8V3FGC4J77 / technetium Tc 99m diphosphonate; CH46OC8YV4 / Gallium; K2I13DR72L / Gadolinium DTPA
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36. Mendenhall WM, Zlotecki RA, Scarborough MT, Gibbs CP, Mendenhall NP: Giant cell tumor of bone. Am J Clin Oncol; 2006 Feb;29(1):96-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of bone.
  • OBJECTIVE: To discuss the treatment and outcomes for giant cell tumor (GCT) of bone.
  • RESULTS: GCT is a rare benign bone lesion most often found in the extremities of women in the third and fourth decades of life.
  • Patients with extensive, recurrent, and/or biologically more aggressive tumors may require wide excision.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / surgery. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Curettage. Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant

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  • (PMID = 16462511.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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37. Karkuzhali P, Chithralekha S, Muthuvel E, Daniel RB: Chondromyxoid fibroma of the parietal bone. Neuropathology; 2005 Mar;25(1):84-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondromyxoid fibroma of the parietal bone.
  • We report the case of an 11-year old girl who presented with an intracranial chondromyxoid fibroma arising from parietal bone.
  • Chondromyxoid fibroma is a benign cartilaginous neoplasm, which can be easily mistaken for chondrosarcoma, especially in small biopsies.
  • To our knowledge, this is the second case of chondromyxoid fibroma reported to occur in parietal bone and is the first case reported in an English-language journal.
  • [MeSH-major] Chondroblastoma / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Dura Mater / pathology. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 15822822.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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38. Adams SC, Potter BK, Robinson PG, Temple HT: Giant cell tumor of the distal femur associated with complete tumor necrosis. Orthopedics; 2010 Sep;33(9):688
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the distal femur associated with complete tumor necrosis.
  • Giant cell tumor is a benign tumor of bone with a predilection for juxta-articular locations.
  • Although not malignant, giant cell tumor often exhibits unpredictable and locally aggressive behavior, and in rare cases can metastasize in the absence of histologic malignancy.
  • Partial tumor necrosis has been infrequently reported within typical giant cell tumor.
  • A 17-year-old girl presented with a right distal femur giant cell tumor associated with complete tumor necrosis on histopathologic analysis.
  • The etiology, prevalence, and implications of complete necrosis in previously untreated giant cell tumor of bone remain unclear, as there are no previously published reports.
  • There were no radiographic signs of the necrotic tumor space remodeling with new bone.
  • The patient was treated with standard extended intralesional curetting through a generous cortical window permitting visualization of the entire lesion, and systematic high speed burring and thermal electrocautery ablation of the periphery, followed by micro particulate allogenic bone grafting.
  • At short-term follow-up, she had healed well with no evidence of tumor recurrence.
  • This article presents the first case, to our knowledge, of complete spontaneous tumor necrosis in a previously untreated bone giant cell tumor.
  • Increased understanding of spontaneous tumor necrosis associated with giant cell tumor may help guided future targeted medical and surgical treatment modalities.
  • [MeSH-major] Femoral Neoplasms / pathology. Giant Cell Tumor of Bone / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20839701.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Farkash EA, Ferry JA, Harris NL, Hochberg EP, Takvorian RW, Zuckerman DS, Sohani AR: Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfalls. J Hematop; 2009;2(4):237-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Breast involvement by lymphoma is uncommon and poses challenges in diagnosis.
  • Lymphomas may clinically, radiologically, and morphologically mimic both benign and neoplastic conditions.
  • The second case, hairy cell leukemia involving the breast and ipsilateral axillary sentinel lymph node, is, to our knowledge, the first reported case of hairy cell leukemia involving the breast at the time of diagnosis.
  • While a localized bone lesion was present at time of diagnosis, bone marrow involvement was relatively mild in comparison to that seen in the breast and lymph node.
  • In the first case, lymphoma occurred in a clinical setting where malignancy was unsuspected, highlighting the importance of careful morphologic evaluation of paucicellular samples, as well as awareness of rare clinicopathologic entities, in avoiding a misdiagnosis of a benign inflammatory infiltrate.
  • In the second case, the lymphoid neoplasm exhibited classic morphologic and immunophenotypic features, but presented at an unusual site of involvement.
  • Knowledge of the patient's concurrent diagnosis of hairy cell leukemia involving the bone marrow and bone helped avoid a misdiagnosis of carcinoma rather than lymphoma.

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  • [Cites] Acta Medica (Hradec Kralove). 2003;46(4):175-7 [14965169.001]
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  • (PMID = 20309431.001).
  • [ISSN] 1865-5785
  • [Journal-full-title] Journal of hematopathology
  • [ISO-abbreviation] J Hematop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2798933
  • [Keywords] NOTNLM ; Anaplastic large cell lymphoma / Anaplastic lymphoma kinase / Breast / Breast implant / Hairy cell leukemia / Primary breast lymphoma / Seroma / T-cell neoplasm
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40. Sierra RJ, Cabanela ME: Total hip arthroplasty in patients with underlying fibrous dysplasia. Orthopedics; 2009 May;32(5):320
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fibrous dysplasia is a developmental anomaly of bone formation that accounts for approximately 7% of benign bone tumors.
  • The results of THA in patients with this disorder is not known.
  • [MeSH-major] Arthroplasty, Replacement, Hip / instrumentation. Arthroplasty, Replacement, Hip / methods. Fibrous Dysplasia of Bone / complications. Fibrous Dysplasia of Bone / surgery. Hip Joint / surgery. Joint Instability / etiology. Joint Instability / surgery

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  • (PMID = 19472968.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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41. Kim MS, Lee SY, Cho WH, Song WS, Koh JS, Lee JA, Yoo JY, Shin DS, Jeon DG: Prognostic effects of doctor-associated diagnostic delays in osteosarcoma. Arch Orthop Trauma Surg; 2009 Oct;129(10):1421-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Initial clinical impressions were of a benign bone tumor in 15 patients, fracture in 8, and infection in 3.
  • After initial inappropriate procedures, primary surgeons failed to send a tissue sample to a pathologist for definite diagnosis in 12 cases, and pathologists made incorrect diagnoses in the other 14.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteosarcoma / diagnosis

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  • (PMID = 19280203.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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42. Orhan Z, Oktas B, Yildirim U: An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: a case report. Knee Surg Sports Traumatol Arthrosc; 2009 May;17(5):518-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis (PVS) is a benign proliferative disorder of unknown origin that affects synovial joints, most commonly the knee.
  • Although this disease is categorized as an inflammatory process rather than a neoplasm, it may be locally destructive and involve muscles, tendons, bone and skin.
  • [MeSH-major] Peroneal Neuropathies / diagnosis. Peroneal Neuropathies / etiology. Synovitis, Pigmented Villonodular / complications. Synovitis, Pigmented Villonodular / diagnosis

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  • [Cites] Knee. 2007 Oct;14 (5):390-4 [17600720.001]
  • [Cites] Arthroscopy. 2001 May;17(5):527-31 [11337722.001]
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  • [Cites] Knee. 2007 Mar;14(2):99-106 [17161949.001]
  • [Cites] Clin Orthop Relat Res. 1996 Apr;(325):174-80 [8998871.001]
  • (PMID = 19205665.001).
  • [ISSN] 1433-7347
  • [Journal-full-title] Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
  • [ISO-abbreviation] Knee Surg Sports Traumatol Arthrosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. Ramboaniaina S, Hoang DV, Berger M: [Aneurysmal carpal scaphoid cyst. A case report]. Chir Main; 2009 Feb;28(1):46-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aneurysmal bone cyst is a rare, benign bone tumor and its location in the carpal scaphoid has never been described in the literature.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Scaphoid Bone / radiography

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  • (PMID = 19095484.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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44. Niethard M, Rogalski M, Deja M, Zacher J: [Partial physeal growth arrest with increasing genu varum deformity caused by a cortical enchondroma--a case report]. Z Orthop Unfall; 2008 Nov-Dec;146(6):725-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The X-ray and MRI investigations have shown a benign lesion like osteofibroma of the mediodistal femur with an affection of the medial physis.
  • 1) resection of the benign lesion and arthroscopically assisted resection of the bony bar with fat-patch interposition;.
  • CONCLUSION: In cases of rare partial bridging of the physis induced by a benign bone tumour one can achieve early correction of axial deviation during growth with resection, interposition of a fat patch and temporary hemiepiphyseodesis.
  • [MeSH-major] Arthroscopy. Bone Malalignment / surgery. Bone Plates. Cartilage, Articular / surgery. Chondroma / surgery. Femur / surgery. Growth Plate / surgery. Knee Joint / surgery

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  • (PMID = 19085720.001).
  • [ISSN] 1864-6697
  • [Journal-full-title] Zeitschrift für Orthopädie und Unfallchirurgie
  • [ISO-abbreviation] Z Orthop Unfall
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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45. Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M: Osteochondromas: review of the clinical, radiological and pathological features. In Vivo; 2008 Sep-Oct;22(5):633-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones.
  • This tumor takes the form of a cartilage-capped bony outgrowth on the surface of the bone.
  • Approximately 15% of osteochondromas occur as multiple lesions in the context of hereditary multiple osteochondromas (HMOs), a disorder that is inherited in an autosomal dominant manner.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Osteochondroma / pathology. Osteochondroma / radiography

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  • (PMID = 18853760.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 125
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46. Moon IS, Kim J, Lee HK, Lee WS: Surgical treatment and outcomes of temporal bone chondroblastoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1447-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment and outcomes of temporal bone chondroblastoma.
  • Chondroblastoma is an uncommon primary benign bone tumor that usually arises in the epiphyses of the long bones.
  • Temporal bone chondroblastoma is a rare primary bone tumor that affects the floor of the middle cranial fossa and temporomandibular joint (TMJ).
  • The biological nature of temporal bone chondroblastoma is occasionally aggressive because of local invasion and is known to have a high recurrence after curettage.
  • The authors have retrospectively analyzed four cases of temporal bone chondroblastoma that had been completely excised by a single surgeon with an eventual long-term follow-up.
  • In all cases, the tumor involved the middle cranial fossa dura and the mandibular fossa with variable degree of infiltration.
  • All patients have had no tumor recurrence to date (mean follow-up period of 5 years).
  • Complete surgical resection of the temporal bone chondroblastoma is the gold standard for treatment.
  • Precise preoperative image evaluation of tumor extension and proper management of the dura mater and temporomandibular joint (TMJ) are the major important features in complete surgical removal that minimize complications in temporal bone chondroblastoma treatment.
  • [MeSH-major] Chondroblastoma / surgery. Skull Neoplasms / surgery. Temporal Bone

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  • (PMID = 18401591.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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47. Cordeiro SZ, Cordeiro Pde B, Sousa AM, Lannes DC, Pierro GS: Giant cell tumor of the rib occupying the entire hemithorax. J Bras Pneumol; 2008 Mar;34(3):185-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the rib occupying the entire hemithorax.
  • The authors report the case of a 28-year-old female patient with a giant cell tumor originating from the rib.
  • The tumor, measuring 25 x 17 cm, occupied the entire hemithorax and caused atelectasis of the left lung.
  • This tumor was a benign mesenchymal neoplasm, which rarely affects the ribs.
  • A thoracotomy involving en bloc resection of the chest wall and tumor was performed.
  • Despite the large dimensions of the tumor, complete resection was possible, and lung function was restored.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Ribs

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  • (PMID = 18392468.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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48. Forsyth RG, De Boeck G, Bekaert S, De Meyer T, Taminiau AH, Uyttendaele D, Roels H, Praet MM, Hogendoorn PC: Telomere biology in giant cell tumour of bone. J Pathol; 2008 Apr;214(5):555-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Telomere biology in giant cell tumour of bone.
  • Giant cell tumour of bone (GCTB) is a benign bone tumour known for the unpredictable clinical behaviour of recurrences and, in rare instances, distant metastases.
  • GCTB has often been regarded as a polyclonal tumour, but more recently a recurrent specific aberration was reported, which suggests a possible role for disturbed telomere maintenance.
  • [MeSH-major] Bone Neoplasms / genetics. Giant Cell Tumors / genetics. Telomere / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Humans. In Situ Hybridization, Fluorescence. Male. Microscopy, Confocal. Middle Aged. Neoplasm Proteins / metabolism. Nuclear Proteins / metabolism. Osteoclasts / metabolism. Osteoclasts / pathology. Phosphoproteins / metabolism. RNA-Binding Proteins / metabolism. Telomerase / metabolism. Transcription Factors / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland
  • (PMID = 18278785.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / nucleolin; 143220-95-5 / PML protein, human; EC 2.7.7.49 / Telomerase
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49. Tan GC, Shiran MS, Swaminathan M, Phang KS, Rohaizak M: Large retrosternal parathyroid carcinoma with primary hyperparathyroidism. Asian J Surg; 2007 Oct;30(4):286-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Parathyroid carcinoma is an indolent tumour with rather low malignant potential.
  • Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection.
  • Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase.
  • We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia.

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  • (PMID = 17962134.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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50. Durand S, Hamcha H, Pannier S, Padovani JP, Finidori G, Glorion C: [Fibrous dysplasia of the proximal femur in children and teenagers: surgical results in 22 cases]. Rev Chir Orthop Reparatrice Appar Mot; 2007 Feb;93(1):17-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] La dysplasie fibreuse de l'extrémité proximale du fémur chez l'enfant et l'adolescent: résultats du traitement chirurgical dans 22 cas.
  • PURPOSE OF THE STUDY: Fibrous dysplasia is a rare benign bone tumor which occurs preferentially in the proximal femur.
  • For the monostotic forms, the type of treatment depended on the size of the tumor and its localization but curettage was used in all cases.
  • Nearly total involution of the tumor was noted in 75% of patients.
  • [MeSH-major] Femur / surgery. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Density Conservation Agents / therapeutic use. Bone Nails. Child. Child, Preschool. Cohort Studies. Curettage. Diphosphonates / therapeutic use. Female. Fibrous Dysplasia, Monostotic / surgery. Fibrous Dysplasia, Polyostotic / surgery. Humans. Internal Fixators. Male. Osteotomy / instrumentation. Osteotomy / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 17389820.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates
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51. Ogbureke KU, Nashed MN, Ayoub AF: Huge peripheral osteoma of the mandible: a case report and review of the literature. Pathol Res Pract; 2007;203(3):185-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteomas are rare benign tumors of bone commonly occurring in the maxillofacial skeleton.

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  • (PMID = 17307307.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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52. Inoue N, Izui-Sarumaru T, Murakami Y, Endo Y, Nishimura J, Kurokawa K, Kuwayama M, Shime H, Machii T, Kanakura Y, Meyers G, Wittwer C, Chen Z, Babcock W, Frei-Lahr D, Parker CJ, Kinoshita T: Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood; 2006 Dec 15;108(13):4232-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In both cases, der(12) had a break within the 3' untranslated region of HMGA2, the architectural transcription factor gene deregulated in many benign mesenchymal tumors, that caused ectopic expression of HMGA2 in the bone marrow.
  • These observations suggest that aberrant HMGA2 expression, in concert with mutant PIGA, accounts for clonal hematopoiesis in these 2 patients and suggest the concept of PNH as a benign tumor of the bone marrow.
  • [MeSH-major] Biomarkers, Tumor / genetics. Hematopoiesis / genetics. Hemoglobinuria, Paroxysmal / genetics. Membrane Proteins / deficiency. Mutation. Neoplasms / genetics

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  • [Cites] J Biol Chem. 2000 May 12;275(19):14394-400 [10747931.001]
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  • (PMID = 16940417.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K23 RR020043
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / phosphatidylinositol glycan-class A protein
  • [Other-IDs] NLM/ PMC1895453
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53. Röpke M, Boltze C, Meyer B, Neumann HW, Roessner A, Schneider-Stock R: Rb-loss is associated with high malignancy in chondrosarcoma. Oncol Rep; 2006 Jan;15(1):89-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We studied the loss of heterozygosity (LOH) of the Rb gene in 31 formalin-fixed, paraffin-embedded cartilaginous tumors using polymerase chain reaction.
  • The tumors were subdivided into 8 cases of dedifferentiated (DD) chondrosarcoma, 17 cases of conventional chondrosarcoma (nine grade 1, seven grade 2 and one grade 3), 4 enchondromas and 2 chondroblastomas.
  • All tumors with Rb-LOH were immunohistochemically Rb-negative.
  • The only case of DD chondrosarcoma negative for Rb-LOH in both components of the tumor also showed weak expression of the Rb protein in the anaplastic component.
  • All benign cartilaginous tumors, low-grade chondrosarcomas and low-grade tumor components of DD chondrosarcomas were negative regarding Rb-LOH but positive in Rb immunohistostaining.
  • However, it is not a marker for identifying low-grade tumors with a tendency towards progression or local recurrence.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Genes, Retinoblastoma / genetics. Loss of Heterozygosity / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. DNA, Neoplasm / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retinoblastoma Protein / analysis. Retinoblastoma Protein / genetics

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  • (PMID = 16328039.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Retinoblastoma Protein
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54. Keser S, Bayar A: Osteochondroma of the talar neck: a rare cause of callosity of the foot dorsum. J Am Podiatr Med Assoc; 2005 May-Jun;95(3):295-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common benign bone tumor.
  • [MeSH-major] Bone Neoplasms / complications. Callosities / etiology. Osteochondroma / complications. Talus

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  • (PMID = 15901820.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Ethmoidal osteoid osteoma with orbital and intracranial extension - a case report. BMC Ear Nose Throat Disord; 2005 Mar 11;5:2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones of appendicular skeleton.
  • Radical excision of the tumor could thus be achieved through a craniofacial approach.
  • CONCLUSION: Although benign and rare, skull base osteoid osteoma can present with neurological deficit due to its mass effect and involvement of vital structures.

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  • [Cites] Br J Neurosurg. 1998 Apr;12(2):173-5 [11013675.001]
  • [Cites] Am J Clin Pathol. 1975 Mar;63(3):391-6 [1115044.001]
  • [Cites] J Laryngol Otol. 1989 Jun;103(6):634-7 [2769039.001]
  • (PMID = 15760476.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC555567
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56. Simsek A, Sipahioğlu S, Ataoğlu O, Cila E: Clear cell chondrosarcoma of the proximal femur with intrapelvic extension. Arch Orthop Trauma Surg; 2005 Feb;125(1):66-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell chondrosarcoma is a rare tumor that can be easily confused with benign tumors.
  • The aim of this report is to present a case that is rare, initially diagnosed as aneurysmal bone cyst and then chondroblastoma, and has an interesting extension pattern.
  • A 41-year-old male patient was treated for an apparently benign cystic lesion of the right proximal femur by intralesional excision and bone grafting.
  • The pathological diagnosis was aneurysmal bone cyst.
  • Both tumors were resected with a wide margin on the femoral side and a marginal margin on the intrapelvic side.
  • Again, the pathological diagnosis was chondroblastoma.
  • Clinically and pathologically, clear cell chondrosarcoma may be confused with benign bone tumors.
  • This caused a delay in the final diagnosis of this patient and he received inadequate surgical treatment, leading to a hemipelvectomy.
  • We were unable to find an exact explanation for this finding and postulated that tumor cells might have been seeded into the inner wall of the acetabulum during acetabular preparation of the total hip prosthesis.
  • [MeSH-major] Chondrosarcoma / diagnosis. Femoral Neoplasms / diagnosis. Pelvic Neoplasms / secondary. Sarcoma, Clear Cell / diagnosis

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  • (PMID = 15558292.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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57. Cueva-Del Castillo JF, Valdés-Gutiérrez GA, Elizondo-Vázquez F, Pérez-Ortiz O, Piña Barba MC, León-Mancilla BH: [Bone loss treatment, pseudoarthrosis, arthrodesis and benign tumors using xenoimplant: clinical study]. Cir Cir; 2009 Jul-Aug;77(4):287-91; 267-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Bone loss treatment, pseudoarthrosis, arthrodesis and benign tumors using xenoimplant: clinical study].
  • BACKGROUND: Bone loss as a result of arthrodesis, pseudarthrosis, benign tumors and bone defects was treated using a xenoimplant (Nukbone).
  • Twenty eight patients had arthrodesis, 16 were treated with pseudarthrosis, three patients had benign tumors and five patients presented bone defects, which were implanted with Nukbone at the site and was the correct treatment for the problem.
  • CONCLUSIONS: In Mexico, bony xenoimplants (osseous) have been used, all of foreign origin due to the high degree of technological dependence in this country.
  • In this study we describe the use, for the first time, of a Mexican xenoimplant with a patent from the Universidad Nacional Autónoma de México (UNAM).
  • The Mexican xenoimplant is biocompatible and can be adapted to treat pathologies where bony (osseous) material is needed.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Resorption / surgery. Bone Transplantation. Pseudarthrosis / surgery. Transplantation, Heterologous

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  • (PMID = 19919790.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Mexico
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58. Saikia KC, Bhattacharya TD, Bhuyan SK, Talukdar DJ, Saikia SP, Jitesh P: Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects. Indian J Orthop; 2008 Apr;42(2):169-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calcium phosphate ceramics as bone graft substitutes in filling bone tumor defects.
  • BACKGROUND: Synthetic bio-inert materials are currently used as an alternative to autogenous bone graft.
  • The purpose of this study is to analyse the use of HA and beta-TCP in their ceramic forms as a bone graft substitute in filling bone voids after curettage of benign bone tumors.
  • MATERIALS AND METHODS: Twenty-four patients in the age range of 3.5-55 years (mean 14.3 years) having benign bone tumors with bone defects were filled with bone graft substitute following curettage.
  • In 20 patients bone defects were filled with block/granules of HA ceramic and in four with beta-TCP.
  • CONCLUSION: Calcium hydroxyapatite and beta-TCP are excellent bone graft substitutes for autogenous bone graft in filling voids after curettage of benign bone tumors.

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  • [Cites] Clin Orthop Relat Res. 1989 Mar;(240):53-62 [2537166.001]
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  • (PMID = 19826522.001).
  • [ISSN] 0019-5413
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2759621
  • [Keywords] NOTNLM ; Benign bone tumor / bone graft substitute / calcium phosphate ceramic / hydroxyapatite
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59. Jerome JT, Sankaran B, Varghese M, Thomas S, Thirumagal SK: Rare presentation of Ewing's sarcoma: a case report and literature review. J Pediatr Orthop B; 2008 Sep;17(5):261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The clinical presentations represent a degree of overlap among various benign and infective etiologies.
  • The diagnosis was confirmed by gold standard biopsy.
  • We present a case of Ewing's tumor in a 13-year-old girl and discuss its rare presentation, and also offer a literature review.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / therapy. Fingers. Sarcoma, Ewing / pathology. Sarcoma, Ewing / therapy
  • [MeSH-minor] Adolescent. Amputation / methods. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Staging. Rare Diseases. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19471180.001).
  • [ISSN] 1473-5865
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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60. Decock CE, Kataria S, Breusegem CM, Van Den Broecke CM, Claerhout IJ: Ectopic meningioma anterior to the lacrimal gland fossa. Ophthal Plast Reconstr Surg; 2009 Jan-Feb;25(1):57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 66-year-old man reported a slowly growing tumor on the lateral edge of his left upper eyelid.
  • A neoplasm of the lacrimal gland was suspected.
  • Resection of the tumor was performed, which was located just behind the orbital septum and in front of the lacrimal gland.
  • Anatomopathologic investigation of the excised specimen with immunohistochemistry revealed a benign meningioma of a meningotheliomatous type, containing multiple bone elements.
  • Therefore, it should be included in the differential diagnosis of a lacrimal gland tumor.

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  • (PMID = 19273931.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucin-1; 0 / Vimentin
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61. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • The peak incidence of this neoplasm is in the first two decades of life.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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62. Manucha V, Ioffe OB: Metastasizing pleomorphic adenoma of the salivary gland. Arch Pathol Lab Med; 2008 Sep;132(9):1445-7
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Metastasizing pleomorphic adenoma of salivary glands is a group of rare tumors that are histologically identical to benign mixed tumors and that inexplicably metastasize.
  • A review of the literature revealed that it usually occurs after multiple local recurrences, and the interval between diagnosis of primary pleomorphic adenoma and metastases ranges between 3 and 52 years.
  • The most common site for metastasis is bone, followed by the head and neck and lung.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Invasiveness / pathology. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / secondary
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18788859.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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63. Wang F, Wang Z, Yao W, Xie H, Xu J, Tian L: Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. J Nucl Med; 2007 Sep;48(9):1442-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor-to-normal tissue tracer values for both (99m)Tc-octreotide and (18)F-FDG were determined using region of interests and expressed as T/N(r) and T/N(m), respectively.
  • Final diagnosis was confirmed by histopathologic analysis or clinical follow-up.
  • Thirteen of the 44 patients had benign lung lesions.
  • In the 31 patients with malignant tumors, all 38 abnormal lymph nodes in 20 patients showed abnormal high focal uptake of (18)F-FDG; only 7 patients with 10 regional lymph adenopathies showed moderate uptake of (99m)Tc-octreotide.
  • Thirteen patients with 39 distant sites of abnormal uptake visualized (imaging stage IV) with (99m)Tc-octreotide included 2 patients with brain metastases, 6 patients with pleural invasion and multiple bone metastasis, 2 patients with contralateral internal lung metastasis and pleural invasion, and 3 patients with only multiple bone metastasis.
  • The final diagnosis was confirmed by histopathology or clinical follow-up.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 17704242.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 99mTc-octreotide; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; RWM8CCW8GP / Octreotide
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64. Hoffmann K, Kerner C, Wilfert W, Mueller M, Thiery J, Hauss J, Witzigmann H: Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients. World J Gastroenterol; 2007 Jan 14;13(2):257-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients.
  • AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas.
  • METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pancreatic benign surgical diseases (n = 15, control group) were included in the study.
  • Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed.
  • All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR.
  • In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage.
  • In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation.
  • CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors (G2/G3).
  • Pancreatic cancer patients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis.
  • CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocarcinoma by CK-19 fluorogenic RT-PCR.
  • In peritoneal lavage, detection rate is correlated with tumor stage and differentiation.
  • In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Pancreatic Ductal / diagnosis. Keratin-19 / genetics. Neoplastic Cells, Circulating / chemistry. Pancreatic Neoplasms / diagnosis. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods
  • [MeSH-minor] Bone Marrow / pathology. Humans. Peritoneal Lavage. RNA, Messenger / analysis. RNA, Messenger / blood

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  • [Cites] Veroff Pathol. 1993;142:1-197 [7504860.001]
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  • (PMID = 17226905.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / RNA, Messenger; 0 / RNA, Neoplasm
  • [Other-IDs] NLM/ PMC4065954
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65. Muramatsu K, Hashimoto T, Seto S, Gondo T, Ihara K, Taguchi T: Low-grade central osteosarcoma mimicking fibrous dysplasia: a report of two cases. Arch Orthop Trauma Surg; 2008 Jan;128(1):11-5
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  • A 24-year-old woman diagnosed as fibrous dysplasia was treated with intra-lesional excision and curettage of the tumor but tumor recurred at 4 months after surgery.
  • A 57-year-old man diagnosed as central osteosarcoma was treated with wide excision of the tumor, followed by reconstruction with the vascularized fibula graft combined with an autogenous irradiated bone graft.
  • Because of the difficulty in distinguishing low-grade central osteosarcoma from a benign lesion, open biopsy is needed to obtain a large tumor sample.
  • Careful clinical and pathological evaluation is required to obtain a definite diagnosis.
  • [MeSH-major] Bone Neoplasms / diagnosis. Femoral Neoplasms / diagnosis. Fibrous Dysplasia of Bone / diagnosis. Osteosarcoma / diagnosis. Tibia
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17203284.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Layadi F, Aniba K, Lmejjati M, Aït Elqadi A, Aït Benali S: [Giant osteoid osteoma of the posterior skull base. A case report and literature review]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):128-32

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  • [Transliterated title] Ostéome ostéoïde géant de l'étage postérieur de la base du crâne. A propos d'un cas et revue de la littérature.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones.
  • Cerebral MRI shows a giant lesion of the posterior cerebral fossa with destruction of the left petrous bone and the left side of the occipital bone.
  • CONCLUSION: Although benign and rare, osteoid osteoma can present with neurological deficit due to mass effect and involvement of nervous structures especially in the posterior skull base.

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  • (PMID = 16840973.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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67. Vaz G, Richard A, Guyen O, Bejui-Hugues J, Carret JP: [Desmoplastic fibroma or bone desmoid tumor: two cases]. Rev Chir Orthop Reparatrice Appar Mot; 2005 Dec;91(8):782-7
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  • [Title] [Desmoplastic fibroma or bone desmoid tumor: two cases].
  • [Transliterated title] Le fibrome desmoplastique ou fibrome desmoïde osseux: à propos de 2 nouveaux cas d'une tumeur osseuse rare.
  • Desmoplastic fibroma or desmoid bone tumor is a rare tumor described for the first time by Jaffe in 1958.
  • It accounts for 0.1 to 0.3% of all benign bone tumors.
  • Histology is required for certain diagnosis of desmoplastic fibroma.
  • The tumor is composed of sparse fibroblasts in a rich background of collagen fibers, a histological presentation exactly the same as soft tissue desmoid fibroma.
  • The observations illustrate the radiological diagnosis.
  • MRI was used to search for local extension in bone or soft tissues.
  • Biopsy is necessary to confirm the diagnosis.
  • Surgery is the optimal treatment, with tumor resection as wide as possible depending on the localization.
  • [MeSH-major] Bone Neoplasms. Fibroma, Desmoplastic. Fibromatosis, Aggressive. Pelvic Bones. Tibia

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  • (PMID = 16553001.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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68. Fenichel I, Garniack A, Morag B, Palti R, Salai M: Percutaneous CT-guided curettage of osteoid osteoma with histological confirmation: a retrospective study and review of the literature. Int Orthop; 2006 Apr;30(2):139-42
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  • Osteoid osteoma is a benign bone tumour usually occurring in young individuals (10-30 years).
  • In the past, surgery was performed in an "open" fashion and the nidus had to be removed with a bone block.
  • The diagnosis was histologically confirmed in 14 cases out of 18 (77%).
  • The use of a cannulated drill and a cannulated curette facilitates efficient removal of the tumour and procurement of tissue for diagnosis.

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  • (PMID = 16474938.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
  • [Other-IDs] NLM/ PMC2532079
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69. Cantwell CP, Scanlon T, Dudeney S, O'Byrne J, Eustace S: CT guided radiofrequency ablation of intra-articular osteoid osteoma of the hip. Ir J Med Sci; 2005 Jul-Sep;174(3):97-9
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  • BACKGROUND: Osteoid osteoma is a painful benign bone tumour.
  • Image guided radiofrequency ablation can be clinically applied to ablate the tumour in a minimally invasive manner.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation. Hip / physiopathology. Joint Diseases / therapy. Osteoma, Osteoid / surgery

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  • (PMID = 16285350.001).
  • [ISSN] 0021-1265
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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70. Hirata M, Murata H, Takeshita H, Sakabe T, Tsuji Y, Kubo T: Use of purified beta-tricalcium phosphate for filling defects after curettage of benign bone tumours. Int Orthop; 2006 Dec;30(6):510-3
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  • [Title] Use of purified beta-tricalcium phosphate for filling defects after curettage of benign bone tumours.
  • Fifty-three patients with benign bone tumours were treated with curettage and filling with a purified beta-tricalcium phosphate (beta-TCP).
  • Radiographically, complete resorption of the material and bone remodelling were achieved in 23 cases (43%).
  • We concluded that purified beta-TCP was an ideal bone graft substitute for the treatment of benign bone tumours because of its good biocompatibility and resorption characteristics.
  • [MeSH-major] Biocompatible Materials / therapeutic use. Bone Neoplasms / surgery. Calcium Phosphates / therapeutic use

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  • (PMID = 16736145.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Calcium Phosphates; 0 / beta-tricalcium phosphate
  • [Other-IDs] NLM/ PMC3172745
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71. Bahamonde L, Catalan J: Bone tumors around the knee: risks and benefits of arthroscopic procedures. Arthroscopy; 2006 May;22(5):558-64
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  • [Title] Bone tumors around the knee: risks and benefits of arthroscopic procedures.
  • Although most primary bone tumors and soft tissue tumors arise around the knee joint, many patients with tumoral conditions attribute their symptoms to traumatic events.
  • Arthroscopy is the preferred method for diagnosis and treatment of knee joint disease, but even a minimally invasive procedure may have adverse consequences in the presence of an unsuspected neoplasm.
  • Arthroscopic biopsy and treatment are recommended for selected intra-articular tumors.
  • In addition, arthroscopy is a useful adjunct during surgical treatment of patients with certain juxta-articular benign bone tumors.
  • In this Current Concepts review, we consider the risks and benefits of arthroscopy in the presence of tumors about the knee joint.
  • [MeSH-major] Arthroscopy. Bone Neoplasms / surgery. Knee Joint
  • [MeSH-minor] Biopsy. Humans. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery

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  • (PMID = 16651168.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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72. Tuzuner T, Kavak A, Parlak AH, Ustundag N: Subungual osteochondroma: a diagnostic dilemma. J Am Podiatr Med Assoc; 2006 Mar-Apr;96(2):154-7
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  • Osteochondroma is the most common skeletal neoplasm of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Nail Diseases / diagnosis. Osteochondroma / diagnosis. Toe Phalanges / pathology

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  • (PMID = 16546954.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Lanza A, Laino L, Rossiello L, Perillo L, Ermo AD, Cirillo N: Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction. Open Dent J; 2008;2:73-7
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  • [Title] Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction.
  • Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph.
  • Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distinguishing benign tumours from their malign counterpart, although the radiographic aspect of the lesion is not always predictive.
  • Therefore a critical differential diagnosis has to be reached to choose the best management.
  • Here, we report a case of giant cell tumour (GCT) whose radiological features by computed tomography (CT) suggested the presence of bone malignancy, whereas the evaluation of a routine OPT scan comforted us about the benign nature of the lesion.
  • A brief review of the literature on such a benign but locally aggressive neoplasm is also provided.

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  • (PMID = 19088886.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2581533
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74. Geniets C, Vanhoenacker FM, Van de Perre S, Van Dyck P, Gielen J, De Schepper AM, Parizel PM: Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features. JBR-BTR; 2006 Sep-Oct;89(5):266-74
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  • [Title] Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features.
  • Benign bone lesions are a fairly common finding in radiology practice.
  • Often, the combination of patient's age and plain radiographic findings are sufficient for diagnosis and obviates the need for further imaging.
  • Generally the following parameters should be assessed in the evaluation of a bone lesion: clinical features, age of the patient, location, size, pattern of bone destruction, cortical involvement, zone of transition, sclerotic margination and matrix calcification.
  • This article reviews the spectrum of clinical and imaging appearances of the most common benign bone tumors.
  • [MeSH-major] Bone Diseases / diagnosis. Bone Neoplasms / diagnosis. Magnetic Resonance Imaging. Radiology. Societies, Medical. Tomography, X-Ray Computed
  • [MeSH-minor] Bone and Bones / pathology. Humans

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  • (PMID = 17147017.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Belgium
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75. Gasbarrini A, Cappuccio M, Donthineni R, Bandiera S, Boriani S: Management of benign tumors of the mobile spine. Orthop Clin North Am; 2009 Jan;40(1):9-19, v

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  • [Title] Management of benign tumors of the mobile spine.
  • In the treatment of primary tumors, complete local eradication is the main goal, as an oncologically appropriate surgical treatment can substantially improve the prognosis and even be considered a life-saving procedure.
  • In deciding the best treatment for primary bone tumors of the spine, the choice of surgery, radiation therapy, chemotherapy, selective arterial embolization, or other medical treatments alone or in combination is based on diagnosis, staging, and a deep understanding of the biology and the behavior of each tumor.
  • This article is a guide to diagnosing and treating such rare tumors.
  • [MeSH-major] Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery
  • [MeSH-minor] Humans. Neoplasm Staging. Spinal Diseases / diagnosis. Spinal Diseases / surgery

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  • (PMID = 19064052.001).
  • [ISSN] 0030-5898
  • [Journal-full-title] The Orthopedic clinics of North America
  • [ISO-abbreviation] Orthop. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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76. Ababneh K, Al-Khateeb T: Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report. J Contemp Dent Pract; 2009;10(6):E072-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report.
  • AIM: The aim of this report is to present the management of an aggressive, highly proliferative pregnancy tumor with clinical and radiographic characteristics highly suggestive of a malignant neoplasm.
  • BACKGROUND: Pregnancy tumor is a benign hyperplastic gingival lesion occurring during pregnancy that is indistinguishable from a pyogenic granuloma arising in nonpregnant females, or in males.
  • Advanced alveolar bone loss also was found beneath the lesion.
  • A malignant process was suspected, and an incisional biopsy revealed a pregnancy tumor.
  • SUMMARY: Pregnancy tumor represents an important differential diagnosis of oral masses and can behave in a very aggressive fashion, mimicking a malignant tumor.
  • CLINICAL SIGNIFICANCE: This lesion should always be included in the differential diagnosis of soft tissue masses in a pregnant woman even if the lesion is clinically very aggressive.
  • [MeSH-major] Alveolar Bone Loss / etiology. Gingival Neoplasms / pathology. Gingival Overgrowth / pathology. Granuloma, Pyogenic / pathology. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mandible. Pregnancy. Treatment Outcome

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  • (PMID = 20020084.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Xiao H, Gong S, Nie X, Guo C, Zhong G: [Ossifying fibroma of the temporal bone]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Oct;20(19):868-70
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  • [Title] [Ossifying fibroma of the temporal bone].
  • OBJECTIVE: To describe the clinical presentation of ossifying fibroma of the temporal bone, and to discuss its diagnosis and treatment.
  • METHOD: A rare case of ossifying fibroma of the temporal bone was presented.
  • Frozen section evaluation during operation was not definitive but suggested benign nature in histology.
  • The tumor was fully resected.
  • RESULT: The final pathological report indicated the stromal cells were negative for S-100 protein and epithelia membrane antigen (EMA), supporting the diagnosis of ossifying fibroma.
  • One-year follow-up showed the sealed EAC was satisfactory with complete interior and no tumor recurred.
  • CONCLUSION: Ossifying fibroma of the temporal bone is a rare entity, which is a benign neoplasm but may show an aggressive behavior by compression and encroachment upon adjacent structures.
  • [MeSH-major] Bone Neoplasms. Fibroma, Ossifying. Temporal Bone / pathology

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  • (PMID = 17168109.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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78. Falcone G, Rossi ED, Maccauro G, de Santis V, Rosa MA, Capelli A, Fadda G: Diagnostic relevance of the immunohistochemical detection of growth factors in benign and malignant cartilaginous tumors. Appl Immunohistochem Mol Morphol; 2006 Sep;14(3):334-40
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  • [Title] Diagnostic relevance of the immunohistochemical detection of growth factors in benign and malignant cartilaginous tumors.
  • The goal of this study was to evaluate the diagnostic relevance of the expression of growth factors in cartilaginous tumors and to investigate on the possible correlation with grade, local recurrence, metastatic potential, and survival.
  • Expression of VEGF, PDGF, FGF1, TFGbeta2, TNFalpha, Ki-67, and p53 was analyzed in 21 cases of benign and malignant cartilaginous tumors using immunohistochemistry.
  • These data suggest a progressive modification in the biologic behavior of malignant cartilaginous tumors.

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  • (PMID = 16932026.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Growth Substances
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79. Schnirring-Judge M, Visser J: Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case. J Foot Ankle Surg; 2009 Jul-Aug;48(4):495-505
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case.
  • Osteochondroma, which is also known as exostosis, is the most common benign bone tumor.
  • In this review, we describe the clinical and diagnostic imaging characteristics of benign bone tumors and, in particular, the osteochondroma and its surgical management.
  • [MeSH-major] Bone Neoplasms / surgery. Hallux / surgery. Osteochondroma / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasms, Post-Traumatic / pathology. Young Adult

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  • (PMID = 19577730.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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80. Takagishi T, Osaki T, Kodate M, Ebi N, Oya M, Yamamoto H: Huge mediastinal cystic tumor penetrating the sternum. Ann Thorac Surg; 2010 Aug;90(2):664-6
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  • [Title] Huge mediastinal cystic tumor penetrating the sternum.
  • We report a very rare case of a huge anterior mediastinal tumor penetrating the sternum that was diagnosed in a 59-year-old woman.
  • The tumor was completely resected en bloc with the manubrium sterni, and the chest wall defect was closed with a pectoralis major muscle flap.
  • Histologic examination of the cystic mass revealed the diagnosis of a benign mediastinal cystic tumor, most likely a benign cystic mature teratoma.
  • [MeSH-major] Bone Neoplasms / pathology. Mediastinal Neoplasms / pathology. Sternum. Teratoma / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20667380.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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81. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • Histologically, the tumors were well delineated and multinodular, separated by fibrous septae.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Three tumors were graded as 2/3 and two 1/3.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • OMFRSEF occur in adults in various locations, but with a common propensity to involve bone; there is recurrent potential and morbidity with higher grade lesions.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [Cites] Cancer Genet Cytogenet. 2000 Jun;119(2):127-31 [10867148.001]
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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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82. Cudney N, Ochs MW, Johnson J, Roccia W, Collins BM, Costello BJ: A unique presentation of a squamous cell carcinoma in a pregnant patient. Quintessence Int; 2010 Jul-Aug;41(7):581-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This report discusses the diagnosis and treatment of this unusual scenario involving progression of a benign lesion to a malignant hybrid.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Verrucous / diagnosis. Mandibular Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Bone Transplantation. Female. Follow-Up Studies. Humans. Mandibular Diseases / diagnosis. Neoadjuvant Therapy. Neoplasm Staging. Odontogenic Cysts / diagnosis. Pregnancy. Reconstructive Surgical Procedures. Skin Transplantation

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  • (PMID = 20614045.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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83. Most MJ, Sim FH, Inwards CY: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg; 2010 Jun;18(6):358-66
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  • Osteofibrous dysplasia (OFD) is a rare, benign, fibro-osseous lesion that typically is seen within the cortex of the tibia in children.
  • Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fibrous Dysplasia of Bone / pathology. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis

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  • (PMID = 20511441.001).
  • [ISSN] 1067-151X
  • [Journal-full-title] The Journal of the American Academy of Orthopaedic Surgeons
  • [ISO-abbreviation] J Am Acad Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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84. Marshall AE, Martin SE, Agaram NP, Chen JH, Horn EM, Douglas-Akinwande AC, Hattab EM: A 61-year-old woman with osteomalacia and a thoracic spine lesion. Brain Pathol; 2010 Mar;20(2):499-502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMT-MCT) is a rare, largely benign, mesenchymal neoplasm almost invariably associated with oncogenic osteomalacia.
  • It is generally found in the soft tissue and bone of the extremities.
  • [MeSH-major] Osteomalacia / diagnosis. Osteomalacia / pathology. Spinal Neoplasms / diagnosis. Spinal Neoplasms / pathology. Thoracic Vertebrae
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasms, Complex and Mixed / complications. Neoplasms, Complex and Mixed / diagnosis. Neoplasms, Complex and Mixed / pathology. Neoplasms, Connective Tissue / complications. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / pathology

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  • (PMID = 20438469.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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85. Kitsoulis PV, Paraskevas G, Vrettakos A, Marini A: A case of eosinophilic granuloma of the skull in an adult man: a case report. Cases J; 2009;2:9144

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eosinophilic granuloma is very rare benign bone tumor which presents in more than 90% in children under the age of ten.
  • A soft, movable, palpable and tender mass was found at the left temporal bone.
  • No periostic reaction or bone formation was noted.
  • An attempt to excise the tumor failed as it had already eroded the underlying temporal bone.
  • Histological diagnosis with dominance of Langerhans cells set the diagnosis.
  • No tenderness, swelling or recurrence is recorded until now.Eosinophilic granuloma is of unknown aetiology but uncontrolled proliferation of Langerhans cells, previous inflammations or tumors and autoimmune disorders are suspected.

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  • (PMID = 20062661.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803941
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86. Yagi M, Ninomiya K, Kihara M, Horiuchi Y: Symptomatic osteochondroma of the spine in elderly patients. Report of 3 cases. J Neurosurg Spine; 2009 Jul;11(1):64-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Whereas osteochondroma is a common benign bone tumor in adolescence, it is rarely observed in elderly patients.
  • In the second case, total removal of the tumor was effective in alleviating clinical symptoms.
  • The pathology of psoriatic arthritis was the accelerating bone turnover and ankylosis.
  • In this report, the authors show that pathological accelerating bone turnover such as psoriatic arthritis may be a possible mechanism for the onset of the enlargement of osteochondromas in elderly patients.
  • [MeSH-major] Osteochondroma / diagnosis. Osteochondroma / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery

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  • (PMID = 19569943.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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87. Siqueira MG, Martins RS, Teixeira MJ: Management of brachial plexus region tumours and tumour-like conditions: relevant diagnostic and surgical features in a consecutive series of eighteen patients. Acta Neurochir (Wien); 2009 Sep;151(9):1089-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of brachial plexus region tumours and tumour-like conditions: relevant diagnostic and surgical features in a consecutive series of eighteen patients.
  • BACKGROUND: Tumours of the brachial plexus region are rare and most publications are case reports or studies with a small series of patients.
  • METHODS: We review 18 patients with tumours in the brachial plexus region submitted to surgical treatment in a 6 year period, including their clinical presentation, neuro-imaging data, surgical findings and outcome.
  • FINDINGS: The tumours comprised a heterogeneous group of lesions, including schwannomas, neurofibromas, malignant peripheral nerve sheath tumour (MPNST), sarcomas, metastases, desmoids and an aneurysmal bone cyst.
  • Eleven tumours were benign and 7 were malignant.
  • CONCLUSIONS: The majority of tumours were benign and most of them could be excised with a low incidence of additional deficits.
  • Some of the malignant tumours could be controlled by surgery plus adjuvant therapy, but this category is still associated with high morbidity and mortality rates.
  • [MeSH-major] Brachial Plexus / pathology. Brachial Plexus / surgery. Brachial Plexus Neuropathies / diagnosis. Brachial Plexus Neuropathies / surgery. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Cysts, Aneurysmal / diagnosis. Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Child. Female. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / physiopathology. Fibromatosis, Aggressive / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / physiopathology. Neoplasm Recurrence, Local / epidemiology. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / physiopathology. Nerve Sheath Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / physiopathology. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / physiopathology. Neurofibroma / surgery. Neurosurgical Procedures. Pain / etiology. Paresthesia / etiology. Postoperative Complications / epidemiology. Retrospective Studies. Sarcoma / diagnosis. Sarcoma / physiopathology. Sarcoma / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19448970.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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88. Baena-Ocampo Ldel C, Ramirez-Perez E, Linares-Gonzalez LM, Delgado-Chavez R: Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution. Ann Diagn Pathol; 2009 Feb;13(1):16-21
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  • [Title] Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution.
  • A retrospective analysis of all bone tumors accessioned at a large referral center (Instituto Nacional de Rehabilitacion) in Mexico City between 2000 and 2005 is presented.
  • A total of 6216 biopsies and surgical resection specimens were reviewed during this period, of which 566 corresponded to bone tumors.
  • Benign bone tumors accounted for 71.6% of cases and malignant bone tumors for 28.4%.
  • The tumors affected men in 53.7% of cases and women in 46.3% of cases, with an average age at presentation of 25 years.
  • The femur was the most common location of the tumors (39.9%), followed by the tibia (17.7%) and humerus (11.8%).
  • The commonest malignant bone tumors were osteosarcoma (46.6%) and chondrosarcoma (8.7%).
  • Of malignant bone tumors, 18.6% corresponded to metastases of carcinomas from internal organs and 8.1% were multiple myeloma.
  • The most common benign bone tumor was osteochondroma (43.7%) followed by giant cell tumor of bone (14.6%) and enchondroma (10.1%).
  • The age distribution showed a peak in children and adolescents comprised predominantly of benign lesions and a second peak in young adults that corresponded to malignant bone tumors (principally osteosarcoma).
  • Malignant bone tumors most often involved the femur, vertebra, and tibia.
  • Geographic location does not appear to represent a risk factor for any particular type of bone tumor and does not affect the age distribution, location, or histopathologic type of the lesions.
  • [MeSH-major] Bone Neoplasms / epidemiology. Bone Neoplasms / pathology. Chondrosarcoma / epidemiology. Chondrosarcoma / pathology. Osteosarcoma / epidemiology. Osteosarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Chondroma / epidemiology. Chondroma / pathology. Female. Giant Cell Tumors / epidemiology. Giant Cell Tumors / pathology. Giant Cell Tumors / secondary. Humans. Incidence. Infant. Male. Mexico / epidemiology. Middle Aged. Osteochondroma / epidemiology. Osteochondroma / pathology. Referral and Consultation. Retrospective Studies. Risk Factors. Urban Population

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  • (PMID = 19118777.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Jonathan A, Rajshekhar V, Chacko G: Chondromyxoid fibroma of the seventh cervical vertebra. Neurol India; 2008 Jan-Mar;56(1):84-7
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  • Chondromyxoid fibroma is a rare benign bone tumor representing less than 0.5% of all bone tumors.
  • A presumptive diagnosis of a bony tumor such as an aneurysmal bone cyst or a giant cell tumor involving the seventh vertebral body was made on plain X-rays, MRI and bone scan.
  • He underwent C7 central corpectomy, incomplete intralesional curettage with iliac bone grafting and C6 to T1 interspinous wiring.
  • The histological diagnosis was chondromyxoid fibroma.
  • On eight years' follow-up, CT scan showed no progression of the tumor with good alignment and fusion of the graft at the site of the corpectomy.
  • The authors conclude that corpectomy and iliac bone grafting for chondromyxoid fibroma has a good outcome on long-term follow-up.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / pathology. Cervical Vertebrae / pathology. Chondromatosis / complications. Fibroma / complications. Fibroma / pathology

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  • (PMID = 18310848.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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90. Panagopoulos I, Mertens F, Löfvenberg R, Mandahl N: Fusion of the COL1A1 and USP6 genes in a benign bone tumor. Cancer Genet Cytogenet; 2008 Jan 1;180(1):70-3
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  • [Title] Fusion of the COL1A1 and USP6 genes in a benign bone tumor.
  • Aneurysmal bone cyst (ABC) is a benign intraskeletal cyst that often expands rapidly and shows a strong tendency to recur.
  • Here we report a second case of a bone tumor carrying a t(17;17) resulting in a COL1A1-USP6 chimeric gene.
  • [MeSH-major] Bone Neoplasms / genetics. Collagen Type I / genetics. Gene Fusion. Proto-Oncogene Proteins / genetics. Tibia. Translocation, Genetic. Ubiquitin Thiolesterase / genetics
  • [MeSH-minor] Adolescent. Chromosomes, Human, Pair 17. Humans. Male. Neoplasm Regression, Spontaneous

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  • (PMID = 18068538.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Proto-Oncogene Proteins; 0 / collagen type I, alpha 1 chain; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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91. von Falck C, Rosenthal H, Gratz KF, Galanski M: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med; 2007 Aug;32(8):640-2
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  • However, findings in the coregistered CT scan were consistent with nonossfiying fibroma, a common benign skeletal lesion.
  • Combined PET/CT imaging can be helpful to identify benign bone lesions mimicking metastatic or residual disease in F-18 FDG PET as illustrated by this case.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Fibroma / radionuclide imaging. Fluorodeoxyglucose F18. Hodgkin Disease / diagnosis. Lymphoma / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Child. Diagnosis, Differential. False Positive Reactions. Female. Humans. Image Enhancement / methods. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / radionuclide imaging. Radiopharmaceuticals. Subtraction Technique

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  • (PMID = 17667441.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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92. Park YK, Kim EJ, Kim SW: Osteoblastoma of the ethmoid sinus. Skeletal Radiol; 2007 May;36(5):463-7
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  • An osteoblastoma is a benign bone tumor that most often occurs in the vertebral column and the long bones of the extremities.
  • A mixture of ground glass opacity and dense bone was present.
  • Histologically, the lesion was composed of proliferating osteoblasts along with small trabeculae of woven bone and rich vascular fibrous stroma.
  • [MeSH-major] Ethmoid Sinus / pathology. Ethmoid Sinus / surgery. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / surgery

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  • [Cites] Arch Otolaryngol. 1979 Oct;105(10 ):623-5 [485933.001]
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  • (PMID = 17265159.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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93. Ayerza MA, Muscolo DL, Aponte-Tinao LA, Farfalli G: Effect of erroneous surgical procedures on recurrence and survival rates for patients with osteosarcoma. Clin Orthop Relat Res; 2006 Nov;452:231-5
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  • Nine patients had intralesional curettage performed at other institutions based on an erroneous diagnosis of a benign lesion.
  • Response to adjuvant therapy and the amount of previous violation of natural tumor barriers should be evaluated carefully before deciding surgical treatment.
  • [MeSH-major] Bone Neoplasms / mortality. Bone Neoplasms / surgery. Medical Errors. Neoplasm Recurrence, Local / epidemiology. Osteosarcoma / mortality. Osteosarcoma / surgery

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  • (PMID = 16906060.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Henry CJ, Brewer WG Jr, Whitley EM, Tyler JW, Ogilvie GK, Norris A, Fox LE, Morrison WB, Hammer A, Vail DM, Berg J, Veterinary Cooperative Oncology Group (VCOG): Canine digital tumors: a veterinary cooperative oncology group retrospective study of 64 dogs. J Vet Intern Med; 2005 Sep-Oct;19(5):720-4
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  • [Title] Canine digital tumors: a veterinary cooperative oncology group retrospective study of 64 dogs.
  • We compared clinical characteristics and outcomes for dogs with various digital tumors.
  • Risk factors examined included age, weight, sex, tumor site (hindlimb or forelimb), local tumor (T) stage, metastases, tumor type, and treatment modality.
  • Squamous cell carcinoma (SCC) accounted for 33 (51.6%) of the tumors.
  • Other diagnoses included malignant melanoma (MM) (n = 10; 15.6%), osteosarcoma (OSA) (n = 4; 6.3%), hemangiopericytoma (n = 3; 4.7%), benign soft tissue tumors (n = 5; 7.8%), and malignant soft tissue tumors (n = 9; 14%).
  • None of the patient variables assessed, including age, sex, tumor type, site, and stage, had a significant impact on ST.
  • Although metastasis at diagnosis correlated with a shorter LDFI, it did not have a significant impact on ST.
  • On the basis of these findings, early surgical intervention is advised for the treatment of dogs with digital tumors, regardless of tumor type or the presence of metastatic disease.

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  • (PMID = 16231717.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Roy S, Dobson P, Henry L: An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone. J Bone Joint Surg Br; 2005 Oct;87(10):1423-4
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  • [Title] An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone.
  • Osteochondroma is the most common benign bone tumour.
  • We report a case of an isolated osteochondroma which appeared benign on clinical and plain radiographic examination but routine histological analysis revealed non-Hodgkin's lymphoma in the underlying bone.
  • This association has not previously been reported and the case emphasises the importance of routine histological analysis, even if a lesion appears benign.
  • [MeSH-major] Bone Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Osteochondroma / pathology

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  • (PMID = 16189321.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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96. Capodiferro S, Maiorano E, Giardina C, Lacaita MG, Lo Muzio L, Favia G: Osteoblastoma of the mandible: clinicopathologic study of four cases and literature review. Head Neck; 2005 Jul;27(7):616-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteoblastoma is a benign bone tumor accounting for 1% of all bone tumors; it commonly involves the spine and the sacrum of young individuals, with less than 5% being localized to the posterior mandible.
  • METHODS: A retrospective study of four benign osteoblastomas was performed based on a review of the clinical, radiographic, and histopathologic features of all cases.
  • RESULTS: The tumors involved the posterior mandible of young patients (age range, 10-21 years; two male and two female patients) and appeared as painful bone expansions.
  • Histologically, they were composed of osteoid and woven bone surrounded by plump osteoblast-like cells with interposed fibroblasts, inflammatory cells, and red blood cells.
  • CONCLUSIONS: Osteoblastomas may be distinguished from other bone tumors, fibro-osseous lesions, and odontogenic neoplasms on the basis of integrated clinical, radiologic, and histologic features and usually manifest an indolent clinical course.
  • [MeSH-minor] Adolescent. Adult. Child. Diagnosis, Differential. Female. Humans. Male. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 15880408.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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97. Gösling T, Probst C, Länger F, Rosenthal H, Brunnemer U, Krettek C: [Diagnostics and treatment of primary bone tumors]. Chirurg; 2010 Jul;81(7):657-78; quiz 679-80
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  • [Title] [Diagnostics and treatment of primary bone tumors].
  • Primary bone tumors can be either benign or malignant.
  • Metastization is a characteristic feature of malignant bone tumors.
  • Malignant tumors are characterized by a local aggressive and destructive behavior.
  • The behavior of a tumor is dependent on its entity, the differentiation grade and localization and these factors are of decisive importance for the correct therapy.
  • Even benign tumors can behave very aggressively.
  • Many tumors show typical characteristics and if a malignant lesion is suspected a biopsy should be carried out.
  • The approach to malignant tumors is always interdisciplinary.
  • The treatment of primary malignant bone tumors requires a lot of experience and should only be done in specialized centers.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery
  • [MeSH-minor] Adolescent. Biopsy. Bone Cysts, Aneurysmal / diagnosis. Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Bone and Bones / pathology. Bone and Bones / surgery. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neoplasm Staging. Radionuclide Imaging. Sensitivity and Specificity. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20512557.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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98. Freeman SJ, Sonoda LI, Seshadri N, Howard W, Set PA, Balan KK: What is the significance of solitary bony abnormalities on bone scintigrams of children with malignancy? Pediatr Hematol Oncol; 2010 Aug;27(5):380-6
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  • [Title] What is the significance of solitary bony abnormalities on bone scintigrams of children with malignancy?
  • This investigation was undertaken to evaluate the significance of solitary bony abnormalities on bone scintigrams of children with known or suspected malignancy.
  • A total of 215 bone scans were performed in 183 children in order to look for possible metastasis over a 10-year period.
  • Of the remaining 31 lesions, 13 (41.9%) were confirmed as metastases, 17 lesions were proved to be benign, and 1 indeterminate.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone and Bones / radionuclide imaging. Neoplasm Metastasis / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Infant, Newborn. Radionuclide Imaging / methods. Radiopharmaceuticals. Retrospective Studies. Technetium Tc 99m Medronate

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  • (PMID = 20469974.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; X89XV46R07 / Technetium Tc 99m Medronate
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99. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • [Title] Malignant bone tumors.
  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The most common primary malignant bone tumors, osteosarcoma and Ewing's sarcoma, occur in childhood.
  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Secondary sarcomas can occur in previously benign bone lesions and require aggressive treatment.
  • Specific techniques are available for the resection of malignant bone tumors from the upper extremities, lower extremities, pelvis, and spine.
  • The care of patients with primary malignant bone tumors requires a multidisciplinary approach to treatment.
  • [MeSH-major] Bone Neoplasms. Orthopedic Procedures / methods
  • [MeSH-minor] Global Health. Humans. Morbidity. Neoplasm Staging / methods. Prognosis

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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100. Meyer A, Bastian L, Bruns F: Benign giant cell tumor of the spine: an unusual indication for radiotherapy. Arch Orthop Trauma Surg; 2006 Oct;126(8):517-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign giant cell tumor of the spine: an unusual indication for radiotherapy.
  • INTRODUCTION: Giant cell tumors are rare primary bone tumors.
  • CASE REPORT: We report about a 64-year-old female patient presenting with history of three osseous and one pulmonal manifestation of a benign giant cell tumor that have manifested metachronously within 23 years.
  • The two periphery bone and the one pulmonal manifestation were treated surgically with success.
  • Now, a further osseous lesion occurred at the seventh vertebra of the thoracic spine and was treated by dorsal instrumentation and replacement of the seventh vertebra.
  • Nine months later, local recurrence of this benign giant cell tumor developed at the thoracic spine and was treated with radiotherapy with a total dose of 45 Gy.
  • Due to neurological deficits a laminectomy and a stabilization of the destroyed sixth vertebra with bone cement was carried out.
  • Histopathological examination again showed benign giant cell tumor without suspicion of malignancy.
  • CONCLUSION: In the literature the use of radiation therapy remains an appropriate therapy option in benign giant cell tumors with minimal adverse sequelae if primary surgical treatment is not feasible or fails.
  • [MeSH-major] Giant Cell Tumor of Bone / radiotherapy. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16810546.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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