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1. Kurugoglu S, Adaletli I, Mihmanli I, Kanberoglu K: Lumbosacral osseous tumors in children. Eur J Radiol; 2008 Feb;65(2):257-69
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lumbosacral osseous tumors in children.
  • A wide variety of benign and malignant neoplasms in children involve the lumbosacral region.
  • When a solitary lesion of the lower spine occurs, tumors or tumor-like lesions represent an important group of entities for diagnostic consideration.
  • Roentgenograms, which demonstrate bone deviations, should be used as an initial examination.
  • The results should direct further imaging studies, such as computed tomography (CT), magnetic resonance imaging (MRI), and bone scintigraphy.
  • A multimodal radiological approach is helpful in the overall evaluation and differential diagnosis of vertebral lesions in children.
  • Although imaging features, especially of benign lesions, may yield a high percentage of accurate diagnoses, in cases with radiological findings highly suggestive of malignancy, a specific diagnosis cannot always be made, and histopathological findings are essential to achieve the diagnosis that will guide the therapy.
  • [MeSH-major] Lumbosacral Region. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Child. Contrast Media. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Neoplasm Metastasis / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17498904.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 46
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2. Franceschi F, Marinozzi A, Rizzello G, Papalia R, Rojas M, Denaro V: Computed tomography-guided and arthroscopically controlled en bloc retrograde resection of a juxta-articular osteoid osteoma of the tibial plateau. Arthroscopy; 2005 Mar;21(3):351-9
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  • Osteoid osteoma represents approximately 10% to 11% of all the benign bone tumors.
  • The lesion was removed by a rear-entry computed tomography (CT)-guided drill under arthroscopic control and the bony defect filled with bone graft harvested from the proximal tibial metaphysis.
  • The follow-up CT scan 2 years after surgery showed complete excision of the lesion and perfect positioning of the bone graft.
  • [MeSH-major] Arthroscopy / methods. Bone Neoplasms / surgery. Knee Joint / surgery. Osteoma, Osteoid / radiography. Osteoma, Osteoid / surgery. Tibia / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 15756191.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Sadeghi-Azandaryani M, Mendl N, Rademacher A, Hoffmann U, Steckmeier B, Heyn J: Pseudoaneurysm of the popliteal artery due to osteochondroma of the distal femur. Vasa; 2010 Aug;39(3):274-7
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  • Osteochondroma is the most common type of benign bone tumour, and is most often found in the knee region.
  • The lesion is usually clinically silent although it may cause different complications such as fractures of the tumour, bone deformities, neurological disorders, malignant transformation and in rare cases vascular disorders.
  • A delay in diagnosis especially of pseudoaneurysm formation may result in life-threatening situations, extensive operations and lengthy hospital stays.

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  • (PMID = 20737389.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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4. Geniets C, Vanhoenacker FM, Van de Perre S, Van Dyck P, Gielen J, De Schepper AM, Parizel PM: Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features. JBR-BTR; 2006 Sep-Oct;89(5):266-74
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  • [Title] Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features.
  • Benign bone lesions are a fairly common finding in radiology practice.
  • Often, the combination of patient's age and plain radiographic findings are sufficient for diagnosis and obviates the need for further imaging.
  • Generally the following parameters should be assessed in the evaluation of a bone lesion: clinical features, age of the patient, location, size, pattern of bone destruction, cortical involvement, zone of transition, sclerotic margination and matrix calcification.
  • This article reviews the spectrum of clinical and imaging appearances of the most common benign bone tumors.
  • [MeSH-major] Bone Diseases / diagnosis. Bone Neoplasms / diagnosis. Magnetic Resonance Imaging. Radiology. Societies, Medical. Tomography, X-Ray Computed
  • [MeSH-minor] Bone and Bones / pathology. Humans

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  • (PMID = 17147017.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Belgium
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5. Moh EN, Aguehoundé C, Aké YL, Kéita A, Kotaix L: [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child]. Mali Med; 2010;25(1):64-5
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  • [Title] [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child].
  • [Transliterated title] Reconstruction par Fibula non Vascularisee d'un Kyste Osseux Anevrysmal de L'Humerus Chez L'Enfant.
  • Aneurysmal bone cyst is a pseudotumoral bone dystrophy which accounts for 1.5 to 4% of benign bone tumours.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Fibula / transplantation. Humerus / surgery

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  • (PMID = 21436008.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mali
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6. Kefeli M, Gonullu G, Can B, Malatyalioglu E, Kandemir B: Metastasis of adenocarcinoma of the gall bladder to an endometrial polyp detected by endometrial curettage: case report and review of the literature. Int J Gynecol Pathol; 2009 Jul;28(4):343-6
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  • SUMMARY: Polyps are the most common benign lesions in the endometrium.
  • Metastasis to the endometrial polyp from a distant primary tumor is rare.
  • After this diagnosis, bone metastases were detected during radiologic screening.
  • Gastrointestinal tumor metastasis to an endometrial polyp is a very rare event, but if a patient with a known primary extragenital tumor has abnormal vaginal bleeding, the possibility of metastasis should be included in the differential diagnosis.
  • [MeSH-minor] Aged. Dilatation and Curettage. Female. Humans. Immunohistochemistry. Neoplasm Staging

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  • (PMID = 19483630.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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7. Ito Y, Higashiyama T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A: Long-term follow-up for patients with papillary thyroid carcinoma treated as benign nodules. Anticancer Res; 2007 Mar-Apr;27(2):1039-43
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  • [Title] Long-term follow-up for patients with papillary thyroid carcinoma treated as benign nodules.
  • BACKGROUND: The recent prevalence of ultrasonography and fine-needle aspiration biopsy (FNAB) has facilitated the detection and diagnosis of papillary thyroid carcinoma.
  • However, there are still cases that are preoperatively misdiagnosed and treated as benign nodules because ultrasonographic and FNAB findings do not provide sufficient evidence for a malignant diagnosis.
  • PATIENTS AND METHODS: We investigated the prognoses of 56 patients with papillary carcinoma who underwent thyroidectomy without node dissection under a diagnosis of benign nodules.
  • RESULTS: None of the patients underwent further surgery such as completion total thyroidectomy and node dissection after the pathological diagnosis of papillary carcinoma was established.
  • Two patients showed recurrence in the remnant thyroid and one showed recurrence in the bone.
  • CONCLUSION: Papillary carcinomas misdiagnosed as benign nodules on ultrasonography and FNAB are indolent and very slow-growing.
  • Immediate further surgery is not needed for such cases, even if they were resected as benign nodules at the initial surgery.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery. Thyroid Nodule / diagnosis. Thyroid Nodule / surgery
  • [MeSH-minor] Adult. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Diagnostic Errors. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis. Thyroidectomy

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  • (PMID = 17465240.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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8. Saglik Y, Altay M, Unal VS, Basarir K, Yildiz Y: Manifestations and management of osteochondromas: a retrospective analysis of 382 patients. Acta Orthop Belg; 2006 Dec;72(6):748-55
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  • Osteochondromas represent the most common primary bone tumours; they reportedly represent 20-50% of all benign bone tumours and 10-15% of all bone tumours.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Osteochondroma / diagnosis. Osteochondroma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Exostoses, Multiple Hereditary / complications. Exostoses, Multiple Hereditary / diagnosis. Exostoses, Multiple Hereditary / surgery. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17260614.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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9. Azorín D, González-Mediero I, Colmenero I, De Prada I, López-Barea F: Diaphyseal chondroblastoma in a long bone: first report. Skeletal Radiol; 2006 Jan;35(1):49-52
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  • [Title] Diaphyseal chondroblastoma in a long bone: first report.
  • Chondroblastoma is a rare benign bone tumor typically located in the epiphysis.
  • We describe the first case of chondroblastoma arising in the diaphysis of a long bone.

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  • (PMID = 16010594.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. Zouhary KJ, Said-Al-Naief N, Waite PD: Ameloblastic fibro-odontoma: expansile mixed radiolucent lesion in the posterior maxilla: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Oct;106(4):e15-21
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  • Ameloblastic fibro-odontoma (AFO) is a benign tumor that displays properties of both ameloblastic fibroma and compound odontoma.
  • Often, AFO presents clinically as a hamartoma or immature odontoma; however, the tumor can also present with progressive growth causing bone destruction and significant deformity, acting more like a true neoplasm.
  • We report a case of a locally aggressive AFO in the posterior maxilla of a 7-year-old girl and discuss the clinical, radiographic, histopathologic, and conservative therapeutic approach to this locally aggressive tumor.
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Oral Surgical Procedures

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  • (PMID = 18656394.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Toy PC, White JR, Scarborough MT, Enneking WF, Gibbs CP: Distal femoral osteoarticular allografts: long-term survival, but frequent complications. Clin Orthop Relat Res; 2010 Nov;468(11):2914-23
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  • METHODS: We retrospectively reviewed 26 patients who had osteoarticular allograft reconstruction of the distal femur after resection of a malignant or aggressive benign tumor of bone.
  • Lacking the benefit of improved soft tissue attachments inherent in other anatomic sites, we believe this option is most appropriate for restoring bone stock in young patients with expectations of long-term survival.
  • [MeSH-major] Bone Transplantation / adverse effects. Femoral Neoplasms / surgery. Femur / surgery. Graft Survival
  • [MeSH-minor] Adolescent. Adult. Amputation. Child. Female. Humans. Kaplan-Meier Estimate. Limb Salvage. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Recovery of Function. Reoperation. Retrospective Studies. Time Factors. Transplantation, Homologous. Treatment Outcome. Young Adult

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  • (PMID = 20645036.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2947705
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12. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • [Title] Tumors for the general orthopedist: how to save your patients and practice.
  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Sampol Bas C, Peña Viloria C, Giménez García M: [Solitary hypermetabolic bone focus in the initial extension study of a prostate carcinoma]. Rev Esp Med Nucl; 2005 Nov-Dec;24(6):414-7
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  • [Title] [Solitary hypermetabolic bone focus in the initial extension study of a prostate carcinoma].
  • [Transliterated title] Foco óseo hipermetabólico único en el estudio de extensión inicial de un carcinoma de próstata.
  • 56 year old male who was diagnosed of Prostatic Neoplasm by transrectal biopsy after elevated PSA level was found by chance in a routine control.
  • This was followed by a whole body bone scintigraphy with 99mTc-MDP that showed a solitary hypermetabolic lesion within skull.
  • An MRI and a CT head scan were carried out to characterize the isotopic lesion, finding no bone abnormalities to justify the mentioned uptake.
  • Given the absence of a radiological benign diagnosis, a further FDG-PET scan was carried out which did not show either increased glycolytic activity at the left occipital region, or in the prostatic gland.
  • In order to guide the biopsy, a CT head scan was repeated which showed what appeared to be an incipient blastic lesion in the scale of the left occipital bone, establishing the differential diagnosis between a metastasis and a benign process.
  • The anatomopathologic analysis of the bone tissue describes a necrotic process without inflammatory reaction (osteonecrosis).
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Occipital Bone / radionuclide imaging. Osteonecrosis / radionuclide imaging. Prostatic Neoplasms / radionuclide imaging
  • [MeSH-minor] Biomarkers, Tumor / blood. Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Diagnosis, Differential. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Proteins / blood. Positron-Emission Tomography. Prostate-Specific Antigen / blood. Radiopharmaceuticals / pharmacokinetics. Skull Neoplasms / radionuclide imaging. Skull Neoplasms / secondary. Technetium Tc 99m Medronate / pharmacokinetics. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 16324519.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Radiopharmaceuticals; EC 3.4.21.77 / Prostate-Specific Antigen; X89XV46R07 / Technetium Tc 99m Medronate
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14. Cueva del Castillo JF, Francisco Osuna J, Elizondo F, Pérez O, Pérez A, Hernández S, Mejía C: [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report]. Acta Ortop Mex; 2007 Jan-Feb;21(1):31-6
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  • [Title] [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report].
  • [Transliterated title] Aplicación de xenoimplante para el tratamiento de defectos oseos, tumores benignos, seudoartrosis y artrodesis. (Reporte preliminar).
  • OBJECTIVE: To show that the ceramic produced at the Institute for Materials Research, National Autonomous University of Mexico, is an appropriate replacement of bone graft in patients with bone tumors, benign tumors, pseudoarthrosis and arthrodesis treated at "General Ignacio Zaragoza" Regional Hospital.
  • They underwent X-ray evaluation of bone healing using the Montoya classification.
  • The most frequent indication was arthrodesis in 10 patients (45.45%), pseudoarthrosis in 6 (27.27%), benign tumors in 3 (13.63%), and bone defects in 3 (13.63%).
  • Type II to type IV bone healing was observed in the sample.
  • DISCUSSION: The use of ceramic xenoimplants is appropriate as a replacement of bone graft in patients with arthrodesis and bone defects, thus avoiding the need for autologous bone graft.
  • [MeSH-major] Arthrodesis. Bone Neoplasms / surgery. Bone Transplantation. Pseudarthrosis / surgery. Transplantation, Heterologous

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  • (PMID = 17695206.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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15. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Atalar B, Miller RC, Dincbas FO, Geismar JH, Micke O, Akyurek S, Ozyar E: Adult langerhans cell histiocytosis of bones : a rare cancer network study. Acta Orthop Belg; 2010 Oct;76(5):663-8
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  • Langerhans Cell Histiocytosis (LCH) is an uncommon benign bone tumour typically seen in children.
  • The localization of tumours was skull bones in 12 (40%), lower extremity in 6 (20%), thoracic bones in 4 (133%), spine in 3 (10%), pelvis in 2 (6.7%) and multiple sites in 3 (10%) patients.
  • [MeSH-major] Bone Diseases / therapy. Histiocytosis, Langerhans-Cell / therapy


17. Kumar A, Varshney MK, Trikha V, Rastogi S: An unusual presentation of a rare chest wall tumour: giant cell tumour of bone. Joint Bone Spine; 2007 Jan;74(1):100-2
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  • [Title] An unusual presentation of a rare chest wall tumour: giant cell tumour of bone.
  • Giant cell tumour of bone is an aggressive benign bone tumour.
  • We report a case of giant cell tumour of the anterior end of the rib masquerading as a sub-mammary abscess in lactating women.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Thoracic Wall
  • [MeSH-minor] Abscess / diagnosis. Adult. Diagnosis, Differential. Female. Humans. Lactation. Treatment Outcome

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  • (PMID = 17197221.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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18. Chen YR, Chang CN, Tan YC: Craniofacial fibrous dysplasia: an update. Chang Gung Med J; 2006 Nov-Dec;29(6):543-9
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  • Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue.
  • It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton.

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  • (PMID = 17302216.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 50
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19. Dominkus M, Ruggieri P, Bertoni F, Briccoli A, Picci P, Rocca M, Mercuri M: Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institution. Int Orthop; 2006 Dec;30(6):499-504
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  • [Title] Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institution.
  • From 1975 to 1997, 649 cases of benign giant cell tumours of the bone were treated at the Istituto Rizzoli.
  • The time interval between the diagnosis and the appearance of the lung metastases ranged from 3 months to 11.9 years.
  • Histologically, the metastases were identical to the primary bone lesions.
  • Local recurrence of the bone lesion occurred in seven patients before or simultaneously to the metastases.
  • In contrast to previous reports, we could not detect a predominance of the distal radius, but all of the patients had a stage III tumour according to the Enneking criteria of benign lesions.
  • We conclude that even metastatic benign giant cell tumours have an excellent prognosis after adequate resection.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16909252.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3172731
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20. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • [Title] Malignant bone tumors.
  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The most common primary malignant bone tumors, osteosarcoma and Ewing's sarcoma, occur in childhood.
  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Secondary sarcomas can occur in previously benign bone lesions and require aggressive treatment.
  • Specific techniques are available for the resection of malignant bone tumors from the upper extremities, lower extremities, pelvis, and spine.
  • The care of patients with primary malignant bone tumors requires a multidisciplinary approach to treatment.
  • [MeSH-major] Bone Neoplasms. Orthopedic Procedures / methods
  • [MeSH-minor] Global Health. Humans. Morbidity. Neoplasm Staging / methods. Prognosis

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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21. Cudney N, Ochs MW, Johnson J, Roccia W, Collins BM, Costello BJ: A unique presentation of a squamous cell carcinoma in a pregnant patient. Quintessence Int; 2010 Jul-Aug;41(7):581-3
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  • This report discusses the diagnosis and treatment of this unusual scenario involving progression of a benign lesion to a malignant hybrid.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Verrucous / diagnosis. Mandibular Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Bone Transplantation. Female. Follow-Up Studies. Humans. Mandibular Diseases / diagnosis. Neoadjuvant Therapy. Neoplasm Staging. Odontogenic Cysts / diagnosis. Pregnancy. Reconstructive Surgical Procedures. Skin Transplantation

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  • (PMID = 20614045.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Behzatoğlu K, Durak H, Canberk S, Aydin O, Huq GE, Oznur M, Ozyalvaçli G, Yildiz P: Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma? Diagn Pathol; 2009;4:48
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  • [Title] Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
  • Giant cell tumor, excluding its prototype in bone, is usually a benign but local aggressive neoplasm originating from tendon sheath or soft tissue.
  • Giant cell tumors in visceral organs usually accompany epithelial tumors and the clinical behavior of giant cell tumor in urinary bladder is similar to its bone counterpart.
  • Here, we report two cases of giant cell tumor located in urinary bladder in comparison with nine reported cases in the English literature.
  • One of the two cases we present had no concurrent urothelial tumor at the time of diagnosis but had a history of a low grade noninvasive urothelial carcinoma with three recurrences.
  • The histology of these two cases was similar to the giant cell tumor of bone and composed of oval to spindle mononuclear cells with evenly spaced osteoclast-like giant cells.
  • The histologic and immunohistochemical properties in our cases as well as their clinical courses were consistent with a giant cell tumor.
  • Consequently, tumors in urinary bladder showing features of giant cell tumor of bone may also be considered and termed "giant cell tumor".

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  • (PMID = 20043822.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2811699
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23. Aneiros-Fernandez J, Caba-Molina M, Arias-Santiago S, Ovalle F, Hernandez-Cortes P, Aneiros-Cachaza J: Myositis ossificans circumscripta without history of trauma. J Clin Med Res; 2010 May 19;2(3):142-4
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  • Myositis ossificans circumscripta is a form of heterotopic ossification that is benign in nature associated to a trauma, but may appear clinically and radiologically as a malignant neoplasm.
  • We discuss some of the difficulties of diagnosis and histological evolution of the lesion.
  • KEYWORDS: Myositis ossificans; Thigh; Differential diagnosis; Nontraumatic.

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  • (PMID = 21629528.001).
  • [ISSN] 1918-3011
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
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24. Prado MP, Mendes AA, Amodio DT: Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports. Einstein (Sao Paulo); 2010 Sep;8(3):354-7
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  • [Title] Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports.
  • Two cases of benign chondral tumors of the talar neck region (an osteoid osteoma and a chondroblastoma) were described.

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  • (PMID = 26760154.001).
  • [ISSN] 1679-4508
  • [Journal-full-title] Einstein (São Paulo, Brazil)
  • [ISO-abbreviation] Einstein (Sao Paulo)
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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25. Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M: Osteochondromas: review of the clinical, radiological and pathological features. In Vivo; 2008 Sep-Oct;22(5):633-46
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  • Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones.
  • This tumor takes the form of a cartilage-capped bony outgrowth on the surface of the bone.
  • Approximately 15% of osteochondromas occur as multiple lesions in the context of hereditary multiple osteochondromas (HMOs), a disorder that is inherited in an autosomal dominant manner.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Osteochondroma / pathology. Osteochondroma / radiography

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  • (PMID = 18853760.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 125
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26. Tanigawa N, Kariya S, Kojima H, Komemushi A, Fujii H, Sawada S: Lower limb ischaemia caused by fractured osteochondroma of the femur. Br J Radiol; 2007 Apr;80(952):e78-80
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  • Osteochondroma is the most common benign bone tumour and can arise in any bone.
  • [MeSH-major] Bone Neoplasms / complications. Exostoses, Multiple Hereditary / complications. Femoral Fractures / complications. Ischemia / etiology. Leg / blood supply


27. Skubitz KM, Manivel JC: Giant cell tumor of the uterus: case report and response to chemotherapy. BMC Cancer; 2007;7:46
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  • [Title] Giant cell tumor of the uterus: case report and response to chemotherapy.
  • BACKGROUND: Giant cell tumor (GCT) is usually a benign but locally aggressive primary bone neoplasm in which monocytic macrophage/osteoclast precursor cells and multinucleated osteoclast-like giant cells infiltrate the tumor.
  • The etiology of GCT is unknown, however the tumor cells of GCT have been reported to produce chemoattractants that can attract osteoclasts and osteoclast precursors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Giant Cell Tumors / drug therapy. Uterine Neoplasms / drug therapy
  • [MeSH-minor] Angiogenesis Inhibitors / administration & dosage. Antibiotics, Antineoplastic / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Agents, Alkylating / administration & dosage. Bevacizumab. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Hysterectomy. Ifosfamide / administration & dosage. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Middle Aged. Treatment Outcome

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  • (PMID = 17359524.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibiotics, Antineoplastic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents, Alkylating; 2S9ZZM9Q9V / Bevacizumab; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 57
  • [Other-IDs] NLM/ PMC1832205
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28. Yoshioka K, Nagata R, Ueda M, Yamaguchi T, Konishi Y, Hosoi M, Inoue T, Yamanaka K, Iwai Y, Sato T: Phosphaturic mesenchymal tumor with symptoms related to osteomalacia that appeared one year after tumorectomy. Intern Med; 2006;45(20):1157-60
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  • [Title] Phosphaturic mesenchymal tumor with symptoms related to osteomalacia that appeared one year after tumorectomy.
  • A 45-year-old man was admitted to our hospital because of bone pain and hypophosphatemia.
  • He had undergone surgery 2 years previously for a "benign unclassified mesenchymal tumor" in the skull, but there were no clinical symptoms related to osteomalacia.
  • The diagnosis of tumor-induced osteomalacia due to phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) was made by re-examining the pathologic specimens.
  • Clinicians and pathologists should be aware of the existence of PMTMCT especially nonphosphaturic or asymptomatic variants of this disorder.
  • [MeSH-minor] Fractures, Spontaneous / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / complications. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Octreotide / administration & dosage. Octreotide / therapeutic use. Phosphates / therapeutic use. Radiosurgery. Vitamin D / analogs & derivatives. Vitamin D / therapeutic use

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  • (PMID = 17106161.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Phosphates; 1406-16-2 / Vitamin D; 66772-14-3 / 1,25-dihydroxyvitamin D; RWM8CCW8GP / Octreotide
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29. Basu S, Baghel NS, Puri A, Shet T, Merchant NH: 18 F-FDG avid lesion due to coexistent fibrous dysplasia in a child of embryonal rhabdomyosarcoma: source of false positive FDG-PET. J Cancer Res Ther; 2010 Jan-Mar;6(1):92-4
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  • With increasing use of 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in the current oncological practice, there is a growing body of evidence of false positive scans due to various benign conditions.
  • The scan was extended up to foot in view of the fact that a prior bone scan had shown a focal uptake in the similar location.
  • A histopathological diagnosis was sought for and the lesion was subsequently proven to be fibrous dysplasia by histopathology of the bone piece obtained from the right tibial lesion by J needle biopsy.
  • The present case is a useful addition to the current body of literature of false positive 18 F-FDG-PET study due to a benign skeletal pathology and underscores the importance of high index of suspicion and careful clinicoradiopathologic correlation, whenever one comes across such an unusual PET finding.
  • [MeSH-major] Fibrous Dysplasia of Bone / radionuclide imaging. Fluorodeoxyglucose F18. Radiopharmaceuticals. Rhabdomyosarcoma, Embryonal / radionuclide imaging. Soft Tissue Neoplasms / radionuclide imaging
  • [MeSH-minor] Child. False Positive Reactions. Humans. Male. Neoplasm Metastasis / pathology. Positron-Emission Tomography. Tibia / pathology

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  • (PMID = 20479556.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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30. Abula A, Abaiyedula A, Yusufu A, Liu C, Huang H: [Preliminary clinical application of cancellous granule-type calcium phosphate cement]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Sep;24(9):1100-2
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  • OBJECTIVE: To investigate the clinical efficacy of the cancellous granule-type calcium phosphate cement in repair bone defect.
  • METHODS: Between July 2008 and July 2009, 35 patients (42 limbs) with fractures, nonunion, and benign bone tumor were treated with cancellous granule-type calcium phosphate cement.
  • There were 32 males and 3 females, with an age range from 9 to 73 years (median, 41 years), including 24 limb fractures (19 cases), 4 osteotomy for deformity of ulna and radius (2 cases), 2 femur intertrochanteric bony cysts (2 cases), 3 enchondroma (3 cases), 5 bone defect at donor ilium (5 cases), 3 nonunion (3 cases), and 1 lumbar spinal stenosis (1 case).
  • The size of bone defect was 1-5 cm.
  • Bone defect was repaired with cancellous granule-type calcium phosphate cement (1-5 g).
  • Incision dehiscence occurred in 2 cases, and wounds healed after second debridement and removal of artificial bone.
  • X-ray films showed that bone graft fusion was achieved and bone defect was radically repaired at 6 months after operation and artificial bone was absorbed completely at 12 months.
  • CONCLUSION: Cancellous granule-type calcium phosphate cement can be used as a new graft bone material, which is suitable for defect filling after traumatic fracture, benign bone tumors, and iliac bone donor.
  • [MeSH-major] Bone Cements. Bone Transplantation / instrumentation. Calcium Phosphates / therapeutic use

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  • (PMID = 20939483.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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31. Jonathan A, Rajshekhar V, Chacko G: Chondromyxoid fibroma of the seventh cervical vertebra. Neurol India; 2008 Jan-Mar;56(1):84-7
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  • Chondromyxoid fibroma is a rare benign bone tumor representing less than 0.5% of all bone tumors.
  • A presumptive diagnosis of a bony tumor such as an aneurysmal bone cyst or a giant cell tumor involving the seventh vertebral body was made on plain X-rays, MRI and bone scan.
  • He underwent C7 central corpectomy, incomplete intralesional curettage with iliac bone grafting and C6 to T1 interspinous wiring.
  • The histological diagnosis was chondromyxoid fibroma.
  • On eight years' follow-up, CT scan showed no progression of the tumor with good alignment and fusion of the graft at the site of the corpectomy.
  • The authors conclude that corpectomy and iliac bone grafting for chondromyxoid fibroma has a good outcome on long-term follow-up.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / pathology. Cervical Vertebrae / pathology. Chondromatosis / complications. Fibroma / complications. Fibroma / pathology

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  • (PMID = 18310848.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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32. Fukunaga S, Futani H, Yoshiya S: Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome. World J Surg Oncol; 2007;5:37
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  • BACKGROUND: Osteochondroma is the most common benign bone tumor in the scapula.
  • Removal of the tumor was performed by the use of endoscopically assisted resection.
  • The tumor was resected in a piece-by-piece manner by the use of graspers through the same portal.
  • CT images showed complete tumor resection.
  • [MeSH-major] Bone Neoplasms / surgery. Endoscopy. Osteochondroma / surgery. Scapula

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  • [ISSN] 1477-7819
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  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
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33. Bostan B, Sen C, Gunes T, Erdem M, Koseoglu RD: Osteoid osteoma of the trapezium: case report. J Hand Surg Am; 2010 Apr;35(4):636-8
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  • Osteoid osteoma is a benign bone tumor representing approximately 10% of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Trapezium Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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  • (PMID = 20171814.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Mir NA, Baba AN, Maajid S, Badoo AR, Mir GR: Osteoblastoma of body of the talus--Report of a rare case with atypical radiological features. Foot Ankle Surg; 2010 Jun;16(2):e24-6
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  • Osteoblastoma is a benign bone tumour found commonly in the spine and long tubular bones.
  • Analysis of clinical, radiological and histological findings confirmed the diagnosis of osteoblastoma.
  • [MeSH-major] Bone Neoplasms / radiography. Osteoblastoma / radiography. Rare Diseases. Talus. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Osteotomy / methods

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483122.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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35. Jundt G, Baumhoer D: [Hereditary bone tumors]. Pathologe; 2010 Oct;31(6):471-6
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  • [Title] [Hereditary bone tumors].
  • Familial diseases leading to bone tumor formation are rare.
  • This leads to multiple benign bone tumors, which may undergo secondary malignant transformation (enchondromatosis: enchondromas, multiple hereditary exostoses: osteochondromas) or bone sarcomas, mainly osteosarcomas, such as primary (Li-Fraumeni, Rothmund-Thomson, Werner and Bloom syndromes) or secondary manifestations (retinoblastoma syndrome) of the underlying disease.
  • In contrast to sporadically occurring similar tumors, differences in manifestation in time, topography or histology may be present which can aid in the correct recognition of the underlying syndrome.
  • [MeSH-major] Bone Neoplasms / genetics

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  • (PMID = 20960198.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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36. Dierselhuis EF, Jutte PC, van der Eerden PJ, Suurmeijer AJ, Bulstra SK: Hip fracture after radiofrequency ablation therapy for bone tumors: two case reports. Skeletal Radiol; 2010 Nov;39(11):1139-43
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  • [Title] Hip fracture after radiofrequency ablation therapy for bone tumors: two case reports.
  • In orthopedic surgery, RFA is used for the treatment of benign bone tumors and bone metastases.
  • Complications are rare and, to our knowledge, bone fracture as a complication due solely to RFA has not been reported to date.
  • In this report we describe two patients with a fracture in the calcar region of the femur as a complication of RFA treatment for bone malignancies.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Catheter Ablation / adverse effects. Femoral Fractures / diagnosis. Femoral Fractures / etiology. Magnetic Resonance Imaging. Tomography, X-Ray Computed


37. Wang F, Wang Z, Yao W, Xie H, Xu J, Tian L: Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. J Nucl Med; 2007 Sep;48(9):1442-8
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  • The tumor-to-normal tissue tracer values for both (99m)Tc-octreotide and (18)F-FDG were determined using region of interests and expressed as T/N(r) and T/N(m), respectively.
  • Final diagnosis was confirmed by histopathologic analysis or clinical follow-up.
  • Thirteen of the 44 patients had benign lung lesions.
  • In the 31 patients with malignant tumors, all 38 abnormal lymph nodes in 20 patients showed abnormal high focal uptake of (18)F-FDG; only 7 patients with 10 regional lymph adenopathies showed moderate uptake of (99m)Tc-octreotide.
  • Thirteen patients with 39 distant sites of abnormal uptake visualized (imaging stage IV) with (99m)Tc-octreotide included 2 patients with brain metastases, 6 patients with pleural invasion and multiple bone metastasis, 2 patients with contralateral internal lung metastasis and pleural invasion, and 3 patients with only multiple bone metastasis.
  • The final diagnosis was confirmed by histopathology or clinical follow-up.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 17704242.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 99mTc-octreotide; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; RWM8CCW8GP / Octreotide
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38. Kashkouli MB, Khalatbari MR, Yahyavi T, Borghei Razavi H, Shayanfar N, Parvaresh MM: Primary endo-orbital osteoid osteoma. Orbit; 2008;27(3):211-3
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  • Osteiod osteoma is a small, benign, osteoblastic tumor, which usually affects the long bone of the lower extremities and vertebrae.
  • [MeSH-minor] Adult. Biopsy, Needle. Exophthalmos / diagnosis. Exophthalmos / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18569832.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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39. Li Y, Liang Q, Wen YQ, Chen LL, Wang LT, Liu YL, Luo CQ, Liang HZ, Li MT, Li Z: Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. Cancer Genet Cytogenet; 2010 Apr 15;198(2):97-106
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  • [Title] Comparative proteomics analysis of human osteosarcomas and benign tumor of bone.
  • Proteins extracted from osteosarcoma tissue and benign bone tumors, including osteoblastoma, chondroblastoma, and giant cell tumor of bone, were examined using two-dimensional gel electrophoresis followed by mass spectrometry analysis and database searches.
  • Aberrant expression of cytoskeletal- and microtubule-associated proteins in osteosarcoma may provide an advantage for tumor invasion and metastasis by affecting the stability of microtubule, which consequently influences the prognosis of patients.
  • [MeSH-major] Bone Neoplasms / metabolism. Neoplasm Proteins / analysis. Osteoblastoma / metabolism. Osteosarcoma / metabolism. Proteomics / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Bone and Bones / metabolism. Bone and Bones / pathology. Child. Chondroblastoma / metabolism. Chondroblastoma / pathology. Female. Giant Cell Tumor of Bone / metabolism. Giant Cell Tumor of Bone / pathology. Humans. Male. Middle Aged. Proteome / analysis. Proteome / metabolism. Young Adult


40. Mitra R: Osteitis Condensans Ilii. Rheumatol Int; 2010 Jan;30(3):293-6
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  • Osteitis Condensans Ilii (OCI) is a benign cause of axial low back pain.
  • [MeSH-major] Ilium / pathology. Ilium / physiopathology. Low Back Pain / etiology. Low Back Pain / physiopathology. Osteitis / diagnosis. Osteitis / physiopathology
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Diagnosis, Differential. Humans. Neoplasm Metastasis / diagnosis. Radiography. Radiology. Sacroiliac Joint / diagnostic imaging. Sacroiliac Joint / pathology. Sacroiliac Joint / physiopathology. Spondylitis, Ankylosing / diagnosis. Steroids / therapeutic use

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  • (PMID = 19711079.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Steroids
  • [Number-of-references] 24
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41. Wang W, Tavora F, Sharma R, Eisenberger M, Netto GJ: PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinoma. Urol Oncol; 2009 Sep-Oct;27(5):525-8
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  • OBJECTIVES: Radioimmunoscintigraphy using a radiolabeled antibody against prostate-specific membrane antigen (PSMA) is frequently used to detect prostate carcinoma (PCa) recurrence and metastasis to lymph nodes, soft tissues, and bone.
  • PSMA expression has not been described in benign neoplasms.
  • PSMA expression was evaluated in tumor cells and lesional vessels.
  • RESULTS: All 11 SCH showed tumoral and or vascular staining; 7 (7/11) displayed both vascular and tumoral cell staining; the remaining 4 had only vascular staining (2/11) or tumor cell staining (2/11).
  • The extent of tumoral cell and vascular staining varied widely among lesions (tumor cells: focal in 8 and diffuse in 1; vascular: focal in 7, multifocal in 1, and diffuse in 1 lesion).
  • CONCLUSION: This is the first report of PSMA expression in a benign neoplasm.
  • Given our finding of frequent expression of PSMA in Schwannomas, they should be clinically considered in the differential diagnosis of a lesion that is positive on PSMA radioimmunoscintigraphy study performed during a metastatic work-up of PCa patient.
  • [MeSH-major] Antigens, Surface / biosynthesis. Biomarkers, Tumor / analysis. Glutamate Carboxypeptidase II / biosynthesis. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / radionuclide imaging. Radionuclide Imaging

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  • (PMID = 18534872.001).
  • [ISSN] 1873-2496
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / Biomarkers, Tumor; EC 3.4.17.21 / Glutamate Carboxypeptidase II; EC 3.4.17.21 / glutamate carboxypeptidase II, human
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42. Angiero F, Mellone P, Baldi A, Stefani M: Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo; 2006 Sep-Oct;20(5):665-70
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  • Osteoblastoma is a benign bone tumor of osteoblastic origin.
  • Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy.
  • Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed.
  • [MeSH-major] Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 17091775.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Mendenhall WM, Zlotecki RA, Scarborough MT, Gibbs CP, Mendenhall NP: Giant cell tumor of bone. Am J Clin Oncol; 2006 Feb;29(1):96-9
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  • [Title] Giant cell tumor of bone.
  • OBJECTIVE: To discuss the treatment and outcomes for giant cell tumor (GCT) of bone.
  • RESULTS: GCT is a rare benign bone lesion most often found in the extremities of women in the third and fourth decades of life.
  • Patients with extensive, recurrent, and/or biologically more aggressive tumors may require wide excision.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / surgery. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Curettage. Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant

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  • (PMID = 16462511.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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44. Simonetti S, Mignogna C, La Mantia V, Lanza F, Insabato L: Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report. Tumori; 2009 Jan-Feb;95(1):101-3
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  • [Title] Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report.
  • Intraosseous cavernomas are very rare benign lesions representing less than 1% of all skeletal tumors and most frequently observed in vertebrae and head and neck bones.
  • We report a case of this neoplasm in the distal epiphysis of the third metacarpal bone in a 68-year-old man, along with the clinicopathological findings.
  • The differential diagnosis and a review of the literature are discussed.
  • [MeSH-major] Bone Neoplasms / pathology. Hemangioma, Cavernous / pathology. Metacarpal Bones / pathology

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  • (PMID = 19366066.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Le Bellec Y, Asfazadourian H: [Bizarre parosteal osteochondromatous proliferation (Nora's lesion). Two case reports]. Chir Main; 2005 Oct;24(5):265-9
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  • [Transliterated title] Prolifération ostéocartilagineuse parostéale bizarre ou tumeur de Nora. A propos de deux cas.
  • Bizarre parosteal osteochondromatous proliferation, or Nora's tumor, is an uncommon lesion, involving mostly tubular bones of hands and feet, arising from the cortical surface.
  • It is a benign lesion, characterized by a proliferation of chondroid, bony and fibrous tissues.
  • The diagnosis can be made thanks to imaging techniques and confirmed by histological examination.
  • [MeSH-major] Bone Neoplasms. Fingers. Osteochondroma
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Reoperation. Time Factors

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  • (PMID = 16277154.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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46. Ruhin-Poncet B, Ghoul-Mazgar S, Hotton D, Capron F, Jaafoura MH, Goubin G, Berdal A: Msx and dlx homeogene expression in epithelial odontogenic tumors. J Histochem Cytochem; 2009 Jan;57(1):69-78
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  • [Title] Msx and dlx homeogene expression in epithelial odontogenic tumors.
  • Epithelial odontogenic tumors are rare jaw pathologies that raise clinical diagnosis and prognosis dilemmas notably between ameloblastomas and clear cell odontogenic carcinomas (CCOCs).
  • Although Msx1 expression imitates normal cell differentiation in these tumors, other genes showed a distinct pattern depending on the type of tumor and the tissue involved.
  • In benign ameloblastomas, ISH localized Dlx3 transcripts and inconstantly detected Msx2 transcripts in epithelial cells.
  • Bmp4 was always expressed in all the tumors.
  • Based on the established roles of Msx and Dlx transcription factors in dental cell fates, these data suggest that their altered expression is a proposed trail to explain the genesis and/or the progression of odontogenic tumors.
  • [MeSH-major] Homeodomain Proteins / biosynthesis. Jaw Neoplasms / metabolism. MSX1 Transcription Factor / biosynthesis. Odontogenic Tumors / metabolism. Transcription Factors / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Ameloblastoma / metabolism. Bone Morphogenetic Protein 2 / biosynthesis. Bone Morphogenetic Protein 4 / biosynthesis. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Neoplasm Recurrence, Local. Reverse Transcriptase Polymerase Chain Reaction. Young Adult

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  • (PMID = 18854600.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / BMP4 protein, human; 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Protein 4; 0 / Distal-less homeobox proteins; 0 / Homeodomain Proteins; 0 / MSX1 Transcription Factor; 0 / MSX2 protein; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2605714
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47. Nogueira Drumond JM: EFFICACY OF THE ENNEKING STAGING SYSTEM IN RELATION TO TREATING BENIGN BONE TUMORS AND TUMOR-LIKE BONE LESIONS. Rev Bras Ortop; 2010 Jan;45(1):46-52
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  • [Title] EFFICACY OF THE ENNEKING STAGING SYSTEM IN RELATION TO TREATING BENIGN BONE TUMORS AND TUMOR-LIKE BONE LESIONS.
  • OBJECTIVE: To evaluate the efficacy of the Enneking staging system for determining the prognosis, planning surgical treatment and indicating adjuvant therapy for benign bone tumors (BBT) and tumor-like bone lesions (TBL).
  • METHODS: A retrospective multicenter, descriptive, nonrandomized study was carried out on a representative sample comprising a large series of 165 patients with a total of 168 benign bone tumors and tumor-like bone lesions.
  • Of the 168 tumors treated, only eight (4.8%) could not be controlled in relation to the initial treatment indicated by the Enneking staging system.
  • Tumors classified as active were the most prevalent, comprising 73.2% of the lesions.
  • Tumor recurrence was significantly more frequent (p < 0.001) in the aggressive stage.
  • For latent and active lesions, the study demonstrated the efficacy of both expectant treatment and excision, with or without autogenous bone graft.

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  • (PMID = 27019838.001).
  • [ISSN] 2255-4971
  • [Journal-full-title] Revista brasileira de ortopedia
  • [ISO-abbreviation] Rev Bras Ortop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC4799048
  • [Keywords] NOTNLM ; Bone diseases / Bone neoplasms/diagnosis/epidemiology/pathology/radiography/surgery / Neoplasm staging
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48. Ali TZ, Epstein JI: Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2007 May;31(5):697-705
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  • The most common methods of diagnosis was transurethral resection (TURP) (n=29) and needle biopsy (n=9).
  • Infiltration around benign glands was seen in 10 (36%) cases, with predominantly small nests and AC-P.
  • Metastases developed in 4/29 patients: 1 in lung, 1 in lung and liver, 1 in lung, bone and liver, 1 in penile urethra.
  • Basal cell carcinomas are rare tumors with a broad morphologic spectrum.
  • These tumors predominantly show an indolent course with local infiltrative behavior.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biopsy, Needle. Combined Modality Therapy. Humans. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Retrospective Studies. Transurethral Resection of Prostate

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  • (PMID = 17460452.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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49. Poffyn B, Sys G, Van Maele G, Van Hoorebeke L, Forsyth R, Verstraete K, Uyttendaele D: Radiographic analysis of extracorporeally irradiated autografts. Skeletal Radiol; 2010 Oct;39(10):999-1008
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  • OBJECTIVE: To analyse the long-term radiographic findings of intercalary, pure osteoarticular, and composite bone grafts in patients with primary bone sarcoma who were treated by reimplantation of the bone as an orthotopic autograft.
  • MATERIALS AND METHODS: For this observational clinical study, 107 patients who presented with 108 malignant or locally aggressive benign bone tumours were treated by resection, extracorporeal irradiation (300 Gy), and reimplantation and fixation of the autograft.
  • Bone healing features were evaluated with the International Society of Limb Salvage (ISOLS) graft evaluation method, which assesses fusion, resorption, fracture, graft shortening, fixation, subluxation, joint narrowing, and subchondral bone.
  • CONCLUSION: This reconstruction technique is valid for the three methods described; bone stock is retained and, once the graft has healed, it behaves as normal bone.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / diagnostic imaging. Bone Transplantation / methods. Sarcoma / surgery

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  • (PMID = 20703876.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
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50. Ito Y, Higashiyama T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A: Prognosis of patients with benign thyroid diseases accompanied by incidental papillary carcinoma undetectable on preoperative imaging tests. World J Surg; 2007 Aug;31(8):1672-6
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  • [Title] Prognosis of patients with benign thyroid diseases accompanied by incidental papillary carcinoma undetectable on preoperative imaging tests.
  • BACKGROUND: Despite the recent wide availability of ultrasonography and fine-needle aspiration biopsy, endocrine surgeons often encounter incidental papillary carcinoma (IPC), that is a papillary carcinoma that had gone undetected by preoperative imaging studies but was identified by pathological examination of surgical specimens resected for benign thyroid diseases.
  • METHODS: The present study was developed to investigate the prognoses of 317 patients who underwent surgery for benign diseases involving IPC in comparison with the prognoses of 1,674 patients with clinically apparent papillary carcinoma detected preoperatively and diagnosed.
  • RESULTS: None of the patients underwent further surgery such as completion total thyroidectomy and node dissection immediately after the diagnosis of IPC.
  • To date, 7 patients (2.2%) have had recurrences; 6 of those were locoregional recurrences and one was a bone metastasis.
  • CONCLUSIONS: Because IPC is associated with good prognosis, further surgery, such as completion total thyroidectomy or lymph node dissection immediately after the diagnosis of IPC is not necessary.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Incidental Findings. Longitudinal Studies. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Survival Analysis. Thyroid Diseases / surgery. Thyroidectomy. Treatment Outcome. Unnecessary Procedures

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  • (PMID = 17571205.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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51. Ortakoglu K, Akcam T, Sencimen M, Karakoc O, Ozyigit HA, Bengi O: Osteochondroma of the mandible causing severe facial asymmetry: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):e21-8
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  • Osteochondroma is one of the most common benign tumors of bone.
  • The aim of the present study is to emphasize the importance of stereolithographic models in planning tumor surgery and how it affects the treatment planning, operation time and prognosis.
  • Based on the model evaluation, the tumor was conservatively resected and the condyle left intact, leaving no sequelae.

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  • (PMID = 17331758.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Kumar PV, Monabati A, Tabei SZ, Ramzy M, Husseini SV, Khajeh F: Metastatic follicular thyroid carcinoma diagnosed by fine needle aspiration cytology: a report of 3 cases. Acta Cytol; 2005 Mar-Apr;49(2):177-80
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  • BACKGROUND: Follicular thyroid carcinomas (FTCs) usually have a benign clinical course, with an excellent long-term prognosis and a propensity for vascular invasion.
  • The most common sites of metastases are lung and bone.
  • As part of the routine investigation, bone marrow aspiration and biopsy were performed from the posterior iliac crest and diagnosed as metastatic FTC.
  • CONCLUSION: Cytologic diagnosis of metastatic FTC has been reported rarely.
  • Marginal (fire-flare) vacuoles aid in making the diagnosis of metastatic FTC.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Bone Marrow Neoplasms / secondary. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Anemia / etiology. Biopsy, Fine-Needle. Bone and Bones / pathology. Epithelial Cells / pathology. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis. Skin Neoplasms / secondary

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  • (PMID = 15839624.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Lin SP, Fang YC, Chu DC, Chang YC, Hsu CI: Characteristics of cranial aneurysmal bone cyst on computed tomography and magnetic resonance imaging. J Formos Med Assoc; 2007 Mar;106(3):255-9
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  • [Title] Characteristics of cranial aneurysmal bone cyst on computed tomography and magnetic resonance imaging.
  • Aneurysmal bone cysts are benign bone tumors that most commonly occur in people younger than 30 years.
  • The tumor was soft, fragile, and pulsatile during surgery.
  • The patient was treated with en bloc resection of the tumor with cranioplasty.

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  • (PMID = 17389172.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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54. Fu K, Meng ZB, Li J, Li HC: [Repairing the defect of benign bone tumor with the coralline hydroxyapatite]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 May;33(5):421-4
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  • [Title] [Repairing the defect of benign bone tumor with the coralline hydroxyapatite].
  • OBJECTIVE: To observe the clinical effect of repairing bone defectin post-operation benign tumor with coralline hydroxyapatite(CHAP).
  • The CHAP was implanted into the lesion after bone tumor curettage to 25 patients.
  • The sizes of bone defect ranged from 0.8 cm x 0.5 cm x 0.5 cm to 10 cm x 3.5 cm x 2 cm.
  • X-ray showed that there was osteogenesis at the cortical bone 1 month post-operation.
  • There is corresponding synchronization between bone formation with CHAP biodegradation.
  • The CHAP is an excellent bone defect repairing material.
  • [MeSH-major] Bone Neoplasms / surgery. Ceramics. Giant Cell Tumor of Bone / surgery. Hydroxyapatites. Prostheses and Implants
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Regeneration. Bone Substitutes. Child. Female. Femur / surgery. Humans. Male. Middle Aged

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  • (PMID = 18544846.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / coralline hydroxyapatite
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55. Altay M, Bayrakci K, Yildiz Y, Erekul S, Saglik Y: Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients. J Orthop Sci; 2007 Sep;12(5):415-23
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  • [Title] Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients.
  • BACKGROUND: Secondary malignancies arising from benign bone tumors are rare.
  • Their recognition and diagnosis are difficult, and their slow growth and late recurrence require long-term follow-up.
  • In this study, malignant transformation rates of various histological types of benign cartilage-forming bone tumors in large series were evaluated.
  • METHODS: Between 1986 and 2004, a retrospective analysis of 627 cartilage-forming benign bone tumors revealed that 32 patients had malignant transformation.
  • RESULTS: The rate of malignant transformation for cartilage-originating tumors was 5.1% (solitary osteochondromas 4.2%, multiple osteochondromas 9.2%, solitary enchondromas 4.2%).
  • The average time between the initial diagnosis and malignant transformation was 9.8 years.
  • The tumors generally were well differentiated.
  • Five patients (15.6%) died of tumor recurrence or metastasis at an average of 20.6 months.
  • One patient is alive with tumor at 104 months.
  • CONCLUSIONS: Cartilage-forming benign bone tumors are rather prone to undergo malignant transformation.
  • Although malignant transformation of a benign bone tumor is a rarely encountered situation, orthopedic surgeons should be cautious while following patients with a benign bone neoplasm.
  • [MeSH-major] Bone Neoplasms / pathology. Cartilage / pathology. Chondrosarcoma / secondary. Neoplasms, Second Primary / pathology. Osteochondroma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Transformation, Neoplastic / pathology. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 17909925.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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56. Simpfendorfer CS, Ilaslan H, Davies AM, James SL, Obuchowski NA, Sundaram M: Does the presence of focal normal marrow fat signal within a tumor on MRI exclude malignancy? An analysis of 184 histologically proven tumors of the pelvic and appendicular skeleton. Skeletal Radiol; 2008 Sep;37(9):797-804
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  • [Title] Does the presence of focal normal marrow fat signal within a tumor on MRI exclude malignancy? An analysis of 184 histologically proven tumors of the pelvic and appendicular skeleton.
  • OBJECTIVE: The aim of this study was to determine if the presence of focal normal bone marrow fat signal within a tumor on magnetic resonance imaging excludes malignancy.
  • MATERIALS AND METHODS: One hundred eighty-four histologically proven tumors with available magnetic resonance imaging (MRI) of the appendicular skeleton and pelvis from 184 patients were collected and reviewed at two separate institutions.
  • There were 111 malignant and 73 benign tumors.
  • Two radiologists at each institution, blinded to the diagnosis, reviewed the MRIs independently and reported the presence or absence of normal marrow fat signal within the tumor based upon T1-weighted imaging without fat suppression and T2-weighted imaging with fat suppression and/or short inversion-time inversion recovery (STIR).
  • For each institution, a Fisher's exact test was used to compare the frequency of focal normal marrow fat signal in benign and malignant tumors.
  • Fisher's exact test was also used to compare the frequency of intratumoral fat in benign and malignant lesions for the pooled sample.
  • There were three discrepancies (one malignant and two benign) at site 1 and four discrepancies (two malignant and two benign) at site 2.
  • Reader consensus at site 1 identified normal marrow fat signal within 1 of 50 (2.0%) malignant and three of 14 (21.4%) benign tumors.
  • Reader consensus at site 2 identified normal marrow fat signal within three of 61 (4.9%) malignant and 14 of 59 (23.7%) benign tumors.
  • For the pooled consensus, the frequency of intratumoral fat in benign lesions (17/73, 23.3%) is significantly greater than the frequency in malignant lesions (4/111, 3.6%), p < 0.001.
  • CONCLUSION: The presence of focal normal marrow signal within a tumor is highly suggestive of a benign tumor.
  • [MeSH-major] Adipose Tissue / pathology. Bone Marrow / pathology. Bone Neoplasms / pathology. Magnetic Resonance Imaging / methods. Pelvic Bones / pathology
  • [MeSH-minor] Algorithms. Bayes Theorem. Female. Humans. Male. Neoplasm Metastasis. Predictive Value of Tests. Reproducibility of Results


57. Thomas EO, Gordon J, Smith-Thomas S, Cramer SF: Diffuse uterine leiomyomatosis with uterine rupture and benign metastatic lesions of the bone. Obstet Gynecol; 2007 Feb;109(2 Pt2):528-30
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  • [Title] Diffuse uterine leiomyomatosis with uterine rupture and benign metastatic lesions of the bone.
  • BACKGROUND: We report a case of diffuse uterine leiomyomatosis in pregnancy complicated by uterine rupture and dissemination to the bone.
  • A free-air series performed postoperatively to confirm paralytic ileus revealed multiple lytic bone lesions.
  • The diagnosis of diffuse uterine leiomyomatosis with metastasis was made on histology of the resected uterus and fine-needle aspiration biopsy of the bone.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fetal Death. Leiomyomatosis / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Prenatal Diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cesarean Section. Diagnosis, Differential. Female. Humans. Hysterectomy. Neoplasm Metastasis. Pregnancy. Pregnancy Trimester, First. Tomography, X-Ray Computed. Uterine Rupture


58. Guo Z, Wang Z, Li J, Li XD: [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors]. Zhonghua Wai Ke Za Zhi; 2008 Jun 15;46(12):895-9
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  • [Title] [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors].
  • OBJECTIVE: To evaluate the reconstructive effect of a new pattern of combined reconstruction after periacetabular tumor resections.
  • METHODS: Between March 2001 and March 2007, tumor resections and new pattern of combined reconstructions which consisted of screw-rod system, acetabular reinforcement shell, antibiotic cement and total hip arthroplasty techniques were performed in 23 patients with periacetabular tumors.
  • Seventeen patients had primary malignant tumors including 7 chondrosarcomas, 4 osteosarcomas, 2 Ewing sarcomas, 2 malignant fibrohistiocytomas, 1 malignant Schwannomas, and 1 synovial sarcoma.
  • Other primary tumors were 2 giant cell tumors and 1 aggressive osteoblastoma.
  • Three metastatic bone tumors were also included in this study, and the original sites were thyroid, breast, and ovary.
  • Three primary benign bone tumors belonged to stage III.
  • 8 months (range, 9-73 months) in the patients with primary tumors.
  • CONCLUSIONS: This new combined reconstruction is an effective way to rebuild pelvic ring and maintain hip function with low complication rate after periacetabular tumor resections.
  • [MeSH-major] Acetabulum. Bone Neoplasms / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Arthroplasty, Replacement, Hip. Bone Screws. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19035146.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Rougraff BT: Bone graft alternatives in the treatment of benign bone tumors. Instr Course Lect; 2005;54:505-12
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  • [Title] Bone graft alternatives in the treatment of benign bone tumors.
  • Most bone grafting procedures are done during spinal fusion and to treat patients with skeletal trauma.
  • Very few studies have addressed the bone grafting of skeletal defects after benign bone tumor excision.
  • Contained defects have been treated with autogenous bone grafts, fresh-frozen allografts, freeze-dried allografts, demineralized bone matrix, and ceramic materials.
  • Additionally, bone morphogenetic proteins may provide a future treatment option for bone tumor reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods
  • [MeSH-minor] Bone Substitutes. Ceramics. Humans. Tissue Preservation / methods. Transplantation, Homologous

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  • (PMID = 15948475.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Number-of-references] 30
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60. Summa A, Cerasti D, Crisi G, Ormitti F, Ventura E, Sabato M: Desmoplastic Fibroma of the Mandible: Usefulness of CT and MR Imaging in Diagnosis and Treatment. A Case Report. Neuroradiol J; 2010 Mar;23(1):109-13
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  • [Title] Desmoplastic Fibroma of the Mandible: Usefulness of CT and MR Imaging in Diagnosis and Treatment. A Case Report.
  • Desmoplastic fibroma (DF) is a rare non-metastasizing benign neoplasm of the bone characterized by aggressive local infiltration, also known as desmoid tumour.
  • We also discuss the usefulness of different imaging modalities (CT and MRI) in DF diagnosis and treatment.

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  • (PMID = 24148342.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Camera A, Magri F, Fonte R, Villani L, Della Porta MG, Fregoni V, Manna LL, Chiovato L: Burkitt-like lymphoma infiltrating a hyperfunctioning thyroid adenoma and presenting as a hot nodule. Thyroid; 2010 Sep;20(9):1033-6
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  • BACKGROUND: Most solitary hyperfunctiong regions on thyroid scan consist of benign tissue.
  • This had been performed to search for a primitive tumor in a patient with bone metastasis.
  • Histological analysis of the surgical specimen led to a diagnosis of Burkitt-like large B-cell lymphoma harbored within a thyroid adenoma.
  • After further staging, the final diagnosis was stage IV E Burkitt-like lymphoma with the involvement of the bone and the thyroid.
  • [MeSH-major] Adenoma / diagnosis. Burkitt Lymphoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle. Bone Neoplasms / secondary. Cyclophosphamide / therapeutic use. Dexamethasone / therapeutic use. Doxorubicin / therapeutic use. Humans. Hyperthyroidism / drug therapy. Hyperthyroidism / surgery. Male. Methimazole / therapeutic use. Middle Aged. Neoplasm Staging. Technetium. Vincristine / therapeutic use

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  • (PMID = 20825299.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 554Z48XN5E / Methimazole; 5J49Q6B70F / Vincristine; 7440-26-8 / Technetium; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
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62. Park YK, Kim EJ, Kim SW: Osteoblastoma of the ethmoid sinus. Skeletal Radiol; 2007 May;36(5):463-7
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  • An osteoblastoma is a benign bone tumor that most often occurs in the vertebral column and the long bones of the extremities.
  • A mixture of ground glass opacity and dense bone was present.
  • Histologically, the lesion was composed of proliferating osteoblasts along with small trabeculae of woven bone and rich vascular fibrous stroma.
  • [MeSH-major] Ethmoid Sinus / pathology. Ethmoid Sinus / surgery. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 17265159.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Liang X, Jiang D, Ni W: [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Aug;21(8):785-8
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  • [Title] [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor].
  • OBJECTIVE: To observe the clinical effect and safety of the nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite in repairing the bone defects due to benign bone tumors.
  • METHODS: From January 2003 to May 2005, 38 patients (21 males, 16 females; age, 19-58 years, averaged 38.5 years) with the bone defects due to benign bone tumors were treated with the n-HA/PA66 grains.
  • Among the 37 patients, 11 had fibrous dysplasia, 14 had bone cyst, 10 had giant cell tumor of the bone (Grade I ), and 2 had enchondroma.
  • The tumors ranged in size from 1.0 cm x 0.7 cm x 0.4 cm to 10.0 cm x 4.0 cm x 3.0 cm, with the location of the proximal femur in 12 patients, the distal femur in 7, the proximal tibia in 9, the proximal humerus in 5, the phalanges of the finger in 2, the metacarpal bone in 1, and the calcaneus in 1.
  • All the benign bone tumors underwent the curettage treatment, and then the tumor cavities were filled up with the n-HA/PA66 grains.
  • The incision healing, local inflammatory reaction, rejection, toxic reaction, tumor cavity healing, and function recovery of the limbs were all observed after operation.
  • At 3 to 5.5 months(mean 4 months) after operation, osteogenesis was found in the space filled with the n-HA/PA66 grains.
  • CONCLUSION: The n-HA/PA66 grains have great biological safety, good biocompatibility, and good bone conduction, which are good materials for the bone repair and reconstruction, and can be safely, and effectively used for repairing the bone defects due to benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Substitutes. Hydroxyapatites. Nylons
  • [MeSH-minor] Adult. Biocompatible Materials. Bone Cysts / surgery. Female. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Male. Middle Aged. Nanostructures. Reconstructive Surgical Procedures / methods. Treatment Outcome. Wound Healing. Young Adult

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  • (PMID = 17882867.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / Nylons
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64. Strobel K, Exner UE, Stumpe KD, Hany TF, Bode B, Mende K, Veit-Haibach P, von Schulthess GK, Hodler J: The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT. Eur J Nucl Med Mol Imaging; 2008 Nov;35(11):2000-8
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  • [Title] The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT.
  • OBJECTIVE: To evaluate the value of a dedicated interpretation of the CT images in the differential diagnosis of benign vs. malignant primary bone lesions with 18 fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT).
  • MATERIALS AND METHODS: In 50 consecutive patients (21 women, 29 men, mean age 36.9, age range 11-72) with suspected primary bone neoplasm conventional radiographs and 18F-FDG-PET/CT were performed.
  • Differentiation of benign and malignant lesions was separately performed on conventional radiographs, PET alone (PET), and PET/CT with specific evaluation of the CT part.
  • RESULTS: According to the standard of reference, conventional 17 lesions were benign and 33 malignant.
  • Median SUV(max) was 3.5 for benign lesions (range 1.6-8.0) and 5.7 (range 0.8-41.7) for malignant lesions.
  • In eight patients with bone lesions with high FDG-uptake (SUV(max) >or= 2.5) dedicated CT interpretation led to the correct diagnosis of a benign lesion (three fibrous dysplasias, two osteomyelitis, one aneurysmatic bone cyst, one fibrous cortical defect, 1 phosphaturic mesenchymal tumor).
  • In four patients with lesions with low FDG-uptake (SUV(max) < 2.5) dedicated CT interpretation led to the correct diagnosis of a malignant lesion (three chondrosarcomas and one leiomyosarcoma).
  • Combined PET/CT was significantly more accurate in the differentiation of benign and malignant lesions than PET alone (p = .039).
  • CONCLUSION: Dedicated interpretation of the CT part significantly improved the performance of FDG-PET/CT in differentiation of benign and malignant primary bone lesions compared to PET alone.
  • PET/CT more commonly differentiated benign from malignant primary bone lesions compared with conventional radiographs, but this difference was not significant.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone and Bones / pathology. Fluorodeoxyglucose F18. Image Processing, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Positron-Emission Tomography

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  • (PMID = 18712385.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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65. Roy S, Dobson P, Henry L: An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone. J Bone Joint Surg Br; 2005 Oct;87(10):1423-4
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  • [Title] An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone.
  • Osteochondroma is the most common benign bone tumour.
  • We report a case of an isolated osteochondroma which appeared benign on clinical and plain radiographic examination but routine histological analysis revealed non-Hodgkin's lymphoma in the underlying bone.
  • This association has not previously been reported and the case emphasises the importance of routine histological analysis, even if a lesion appears benign.
  • [MeSH-major] Bone Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Osteochondroma / pathology

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  • (PMID = 16189321.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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66. Abolghasemian M, Rezaie M, Behgoo A, Shoushtarizadeh T, Ghazavi MT: Exostosis-like intra-articular periosteal osteoblastoma: a rare case. Am J Orthop (Belle Mead NJ); 2010 Jun;39(6):E50-3
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  • Osteoblastoma is a relatively rare benign bone tumor, most often located in the vertebral column or metaphysis of the long bones, particularly the femur and the tibia.
  • Exostosis-like appearance is not common even in periosteal osteoblastoma, a very rare type of this tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Hip Joint / pathology. Osteoblastoma / pathology. Periosteum / pathology

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  • (PMID = 20631934.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Sailhan F, Chotel F, Parot R, SOFOP: Chondroblastoma of bone in a pediatric population. J Bone Joint Surg Am; 2009 Sep;91(9):2159-68
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  • [Title] Chondroblastoma of bone in a pediatric population.
  • BACKGROUND: Chondroblastoma is a rare benign bone lesion that occurs in young patients and has a high rate of recurrence.
  • METHODS: We retrospectively reviewed eighty-seven cases of chondroblastoma in patients with open physes at the time of diagnosis and treatment.
  • The treatment consisted of intralesional curettage with autogenous bone-grafting in 63% of the patients.
  • Sex, radiographic aggressiveness, an aneurysmal bone-cyst component on histological analysis, and the method of surgical treatment had no significant influence on recurrence.
  • [MeSH-major] Bone Neoplasms / epidemiology. Chondroblastoma / epidemiology. Femur. Neoplasm Recurrence, Local / epidemiology. Tibia

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  • (PMID = 19723993.001).
  • [ISSN] 1535-1386
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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68. Blackwell JB, Curnow MN: Benign bone tumours in Western Australia, 1972-1996. Pathology; 2007 Dec;39(6):567-74
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  • [Title] Benign bone tumours in Western Australia, 1972-1996.
  • AIMS: To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types.
  • RESULTS: During the 25 year period, 849 benign tumours were accessioned and incidence rates have been calculated for 86 chondromas, 68 osteoid osteomas, 47 giant cell tumours, 32 chondroblastomas, 15 periosteal chondromas and 13 chondromyxoid fibromas.
  • CONCLUSION: The BTR provides a valuable resource for the study of primary bone tumours.
  • This review has established reliable incidence rates for the six most common benign tumours.
  • Such information is rarely available for benign tumours.
  • [MeSH-major] Bone Neoplasms / pathology. Registries
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Western Australia / epidemiology

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  • (PMID = 18027260.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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69. Moon IS, Kim J, Lee HK, Lee WS: Surgical treatment and outcomes of temporal bone chondroblastoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1447-54
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  • [Title] Surgical treatment and outcomes of temporal bone chondroblastoma.
  • Chondroblastoma is an uncommon primary benign bone tumor that usually arises in the epiphyses of the long bones.
  • Temporal bone chondroblastoma is a rare primary bone tumor that affects the floor of the middle cranial fossa and temporomandibular joint (TMJ).
  • The biological nature of temporal bone chondroblastoma is occasionally aggressive because of local invasion and is known to have a high recurrence after curettage.
  • The authors have retrospectively analyzed four cases of temporal bone chondroblastoma that had been completely excised by a single surgeon with an eventual long-term follow-up.
  • In all cases, the tumor involved the middle cranial fossa dura and the mandibular fossa with variable degree of infiltration.
  • All patients have had no tumor recurrence to date (mean follow-up period of 5 years).
  • Complete surgical resection of the temporal bone chondroblastoma is the gold standard for treatment.
  • Precise preoperative image evaluation of tumor extension and proper management of the dura mater and temporomandibular joint (TMJ) are the major important features in complete surgical removal that minimize complications in temporal bone chondroblastoma treatment.
  • [MeSH-major] Chondroblastoma / surgery. Skull Neoplasms / surgery. Temporal Bone

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  • (PMID = 18401591.001).
  • [ISSN] 1434-4726
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70. Pans S, Brys R, Van Breuseghem I, Geusens E: Benign bone tumours of the spine. JBR-BTR; 2005 Jan-Feb;88(1):31-7
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  • [Title] Benign bone tumours of the spine.
  • A wide variety of primary bone tumours can involve the spine.
  • We present an overview of the primary benign bone tumours of the spine.
  • [MeSH-major] Magnetic Resonance Imaging. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Spinal Diseases / diagnosis

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  • (PMID = 15792167.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 16
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71. Kossmann N, Gallachi G: [Local pain of the shoulder - osteoid osteoma]. Praxis (Bern 1994); 2010 Mar 17;99(6):359-5; quiz 366
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  • The cause was later identified in CT as being an osteoid osteoma, a benign bone tumour with high vascularity in the core (nidus) and a surrounding region of sclerosis.
  • These tumours usually develop before the age of thirty and the pain responds exquisitely to non-steroidal antirheumatic medication.
  • The tumour was finally removed (CT-guided drilling excision) whereupon the symptoms disappeared.
  • [MeSH-major] Bone Neoplasms / diagnosis. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetic Resonance Imaging. Osteoma, Osteoid / diagnosis. Scapula / pathology. Shoulder Pain / etiology. Tomography, Spiral Computed
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Young Adult

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  • (PMID = 20235025.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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72. Schaller BJ, Modo M, Buchfelder M: Molecular imaging of brain tumors: a bridge between clinical and molecular medicine? Mol Imaging Biol; 2007 Mar-Apr;9(2):60-71
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  • [Title] Molecular imaging of brain tumors: a bridge between clinical and molecular medicine?
  • As the research on cellular changes has shed invaluable light on the pathophysiology and biochemistry of brain tumors, clinical and experimental use of molecular imaging methods is expanding and allows quantitative assessment.
  • Molecular imaging sets forth to probe the molecular abnormalities that are the basis of disease rather than to visualize the end effects of these molecular alterations and, therefore, provides different additional biochemical or molecular information about primary brain tumors compared to histological methods "classical" neuroradiological diagnostic studies.
  • Common clinical indications for molecular imaging contain primary brain tumor diagnosis and identification of the metabolically most active brain tumor reactions (differentiation of viable tumor tissue from necrosis), prediction of treatment response by measurement of tumor perfusion, or ischemia.
  • The interesting key question remains not only whether the magnitude of biochemical alterations demonstrated by molecular imaging reveals prognostic value with respect to survival, but also whether it identifies early disease and differentiates benign from malignant lesions.
  • [MeSH-major] Brain Neoplasms / diagnosis. Neurons / diagnostic imaging. Positron-Emission Tomography / methods
  • [MeSH-minor] Animals. Cell- and Tissue-Based Therapy. Disease Models, Animal. Disease Progression. Humans. Molecular Probes. Neoplasm Staging. Radiography

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  • (PMID = 17203238.001).
  • [ISSN] 1536-1632
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Molecular Probes
  • [Number-of-references] 135
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73. Cheong JH, Kim JM, Bak KH, Kim CH, Oh YH, Park DW: Bilateral vidian nerve schwannomas associated with facial palsy. Case report and review of the literature. J Neurosurg; 2006 May;104(5):835-9
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  • Intracranial schwannomas are relatively common benign tumors arising from Schwann cells.
  • Preoperative computerized tomography scans and magnetic resonance images revealed nonenhancing round masses within the bilateral vidian canals, bone erosion, and sclerosis.
  • [MeSH-minor] Adolescent. Facial Nerve / pathology. Facial Nerve / surgery. Female. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoplasm, Residual / diagnosis. Postoperative Complications / diagnosis. Sphenoid Bone / surgery. Tomography, X-Ray Computed

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  • [CommentIn] J Neurosurg. 2007 Jan;106(1):202; author reply 202-3 [17236512.001]
  • (PMID = 16703893.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Landa J, Schwartz LH: Contemporary imaging in sarcoma. Oncologist; 2009 Oct;14(10):1021-38
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  • Sarcomas are a heterogeneous group of >50 subtypes of neoplasm.
  • It is imperative to obtain appropriate imaging of these tumors in order to adequately assess, characterize, and stage bone and soft tissue sarcomas.
  • Newer radiopharmaceuticals, such as (18)F-fluorodeoxythymidine, are being developed to assist in the differentiation between benign and low-grade malignant neoplasms.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fluorodeoxyglucose F18. Positron-Emission Tomography. Radiopharmaceuticals. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Metastasis / diagnosis. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19789392.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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75. Benoit MM, Handzel O, McKenna MJ, Deschler DG: A 42-year-old man with facial nerve weakness and multiple recurrent pleomorphic adenoma. Otol Neurotol; 2010 Sep;31(7):1157-9
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  • OBJECTIVE: To describe a case and discuss the differential diagnosis of facial nerve paresis presenting years after resection of multiple recurrent parotid pleomorphic adenoma.
  • MAIN OUTCOME MEASURES: Histopathologic diagnosis and treatment outcome.
  • RESULTS: Final diagnosis of recurrent pleomorphic adenoma causing compression of the facial nerve at the stylomastoid foramen.
  • CONCLUSION: Facial nerve weakness caused by a benign salivary gland tumor is rare.
  • [MeSH-minor] Adult. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Temporal Bone / pathology. Tomography, X-Ray Computed

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  • (PMID = 20657328.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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76. Li J, Wang ZQ, Zhang YM, Song HP, Yuan L: [Application of allogeneic bone in surgical treatment of benign bone neoplasm]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jul;26(7):987-90
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  • [Title] [Application of allogeneic bone in surgical treatment of benign bone neoplasm].
  • OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone.
  • METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft.
  • RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation.
  • The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery.
  • CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods

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  • (PMID = 16864094.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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77. Anil S: Solitary plasmacytoma of the maxilla--a case report and review of the literature. Gen Dent; 2007 Jan-Feb;55(1):39-43
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  • Some lesions appear to be benign and do not recur after complete removal, while others are locally invasive.
  • Radiographic examination revealed an osteolytic lesion over the right maxillary bone, invading the maxillary sinus.
  • A CT scan showed that the tumor mass occupied the right maxillary sinus and the lateral wall of the nasal cavity.
  • The tumor cells were composed of densely packed, round, polygonal cell structures that were scattered in relatively sparse stoma.
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 17333965.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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78. Kitsoulis P, Mantellos G, Vlychou M: Osteoid osteoma. Acta Orthop Belg; 2006 Apr;72(2):119-25
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  • Osteoid osteoma is a relatively frequent benign bone tumour, consisting of osteoid and woven bone, and surrounded by a halo of reactive sclerotic bone, with an average size of the nidus less than 1.5 cm.
  • [MeSH-major] Bone Neoplasms. Osteoma, Osteoid

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  • (PMID = 16768252.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 42
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79. Takagishi T, Osaki T, Kodate M, Ebi N, Oya M, Yamamoto H: Huge mediastinal cystic tumor penetrating the sternum. Ann Thorac Surg; 2010 Aug;90(2):664-6
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  • [Title] Huge mediastinal cystic tumor penetrating the sternum.
  • We report a very rare case of a huge anterior mediastinal tumor penetrating the sternum that was diagnosed in a 59-year-old woman.
  • The tumor was completely resected en bloc with the manubrium sterni, and the chest wall defect was closed with a pectoralis major muscle flap.
  • Histologic examination of the cystic mass revealed the diagnosis of a benign mediastinal cystic tumor, most likely a benign cystic mature teratoma.
  • [MeSH-major] Bone Neoplasms / pathology. Mediastinal Neoplasms / pathology. Sternum. Teratoma / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20667380.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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80. Ando A, Hatori M, Hosaka M, Hagiwara Y, Kita A, Itoi E: Eosinophilic granuloma arising from the pelvis in children: A report of three cases. Ups J Med Sci; 2008;113(2):209-16
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  • Eosinophilic granuloma (EG) is a benign tumor-like condition which is characterized by a clonal proliferation of Langerhans-type histiocytes and defined as a local form of Langerhans cell histiocytosis (LCH).
  • A status of EG in the bone is divided into acute and chronic phases.
  • Radiologically acute phase of EG is difficult to differentiate from a malignant bone tumor such as Ewing's sarcoma or acute osteomyelitis.
  • Chronic phase of EG may mimic a chronic osteomyelitis or a benign bone tumor.
  • These lesions resembled radiologically chronic osteomyelitis (Brodie's abscess) or a benign bone tumor and healed spontaneously after biopsy.
  • It was difficult to differentiate from a malignant tumor such as Ewing's sarcoma, or acute osteomyelitis.
  • Curettage of the affected site and bone grafting is usually accomplished.
  • [MeSH-major] Bone Neoplasms / complications. Eosinophilic Granuloma / etiology. Osteomyelitis / complications. Pelvis

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  • (PMID = 18509815.001).
  • [ISSN] 2000-1967
  • [Journal-full-title] Upsala journal of medical sciences
  • [ISO-abbreviation] Ups. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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81. Gelabert-González M, García-Allut A: Spinal extradural angiolipoma: report of two cases and review of the literature. Eur Spine J; 2009 Mar;18(3):324-35
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  • Spinal angiolipomas are benign uncommon neoplasm composed of mature lipocytes admixed with abnormal blood vessels.
  • They account for only 0.04-1.2% of all spinal tumors.
  • Prior to diagnosis 40.6% of the patients had weakness of the lower limbs.
  • The interval between the initial symptoms and tumor diagnosis ranged from 1 day to 17 years (mean 20.2 months).
  • Spinal angiolipomas are tumors containing angiomatous and lipomatous tissue, predominantly located in the mid-thoracic region.

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  • (PMID = 19127373.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 99
  • [Other-IDs] NLM/ PMC2899409
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82. Oshikawa G, Kurosu T, Arai A, Murakami N, Miura O: Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation. Cancer Genet Cytogenet; 2010 May;199(1):56-61
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  • Chronic myeloid leukemia (CML) with the e19a2 transcript coding for p230 is typically associated with a benign clinical course unless accompanied at presentation with additional chromosomal abnormalities.
  • We report here a case of CML with e19a2 who did not show additional chromosomal abnormalities at diagnosis, but progressed to the fatal advanced stage in approximately 2 years.
  • Nine months after starting imatinib, fluorescence in situ hybridization (FISH) with the BCR/ABL-ES fusion probe revealed 96% and 3% of bone marrow cells with one and two BCR/ABL1 fusion signals, respectively.
  • Two years after starting therapy, leukocytosis recurred and the bone marrow contained 8.2% large and bizarre myeloblasts.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Fusion Proteins, bcr-abl / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Philadelphia Chromosome. Piperazines / therapeutic use. Polyploidy. Pyrimidines / therapeutic use. RNA, Neoplasm / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Base Sequence. Benzamides. Bone Marrow / pathology. Clone Cells. DNA Mutational Analysis. Female. Gene Expression Regulation, Leukemic. Humans. Imatinib Mesylate. In Situ Hybridization, Fluorescence. Karyotyping. Male. Middle Aged. Molecular Sequence Data. RNA, Messenger / genetics. RNA, Messenger / metabolism. Time Factors

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20417871.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / abl-bcr fusion protein, human; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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83. Freschi S, Dodson NB: Osteoid osteoma: an uncommon cause of foot pain. J Am Podiatr Med Assoc; 2007 Sep-Oct;97(5):405-9
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  • An osteoid osteoma located in the forefoot can be difficult to diagnose, and the diagnosis is frequently delayed.
  • Although rarely seen in the metatarsal, osteoid osteoma should be included in the differential diagnosis of foot pain.
  • Findings from radiographs, magnetic resonance images, and a detailed clinical history led to the diagnosis of osteoid osteoma of the left second metatarsal.
  • We review osteoid osteoma, including the classic clinical presentation and treatment associated with this benign bone tumor.

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  • (PMID = 17901347.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Kurli M, Reddy S, Tena LB, Pavlick AC, Finger PT: Whole body positron emission tomography/computed tomography staging of metastatic choroidal melanoma. Am J Ophthalmol; 2005 Aug;140(2):193-9
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  • Two were imaged before treatment of their primary tumor.
  • The mean time from initial diagnosis to metastasis was 47 months (range 0 to 154).
  • The most common sites for metastases were the liver (100%), bone (50%), lung (25%), lymph nodes (25%), and subcutaneous tissue (25%).
  • PET/computed tomography imaging also detected benign lesions of the bone and lymph nodes in three patients (15%).
  • CONCLUSIONS: PET/computed tomography imaging is a sensitive tool for the detection and localization of hepatic and extra-hepatic (particularly osseous) metastatic choroidal melanoma.
  • [MeSH-minor] Aged. Aged, 80 and over. Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Female. Fluorodeoxyglucose F18. Humans. Liver Neoplasms / radionuclide imaging. Liver Neoplasms / secondary. Lung Neoplasms / radionuclide imaging. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 15992753.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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85. Settakorn J, Lekawanvijit S, Arpornchayanon O, Rangdaeng S, Vanitanakom P, Kongkarnka S, Cheepsattayakorn R, Ya-In C, Thorner PS: Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases. J Med Assoc Thai; 2006 Jun;89(6):780-7
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  • [Title] Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases.
  • OBJECTIVE: The aim of the present study was to determine the spectrum, frequency and demographics of bone tumors.
  • MATERIAL AND METHOD: A retrospective study of the 1,001 bone tumor specimens from the files at the Pathology Department of the Chiang Mai University Hospital, Thailand from 2000 to 2004.
  • RESULTS: From the study, 41 were non-neoplastic mass lesions, and 960 were neoplastic, with 856 (89%) as primary and 104 (11%) as metastatic tumors.
  • In the primary tumor group, 654 (76%) cases were of hematologic origin, and 202 (24%) were non-hematologic.
  • The most common benign bone tumors were giant cell tumor (n = 37), osteochondroma (n = 25), and chondroma (n = 15).
  • The most common malignant bone tumors were lymphoma-leukemia (n = 583), metastatic malignancy (n = 104), plasma cell myeloma (n = 71), and osteosarcoma (n = 58).
  • CONCLUSION: The present study showed a higher frequency of osteosarcoma (68%), lower frequencies of chondrosarcoma (12%) and Ewing sarcoma (4%) among primary non-hematologic malignant bone tumors when compared with similar studies based on Western patients.
  • [MeSH-major] Bone Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Giant Cell Tumors / diagnosis. Giant Cell Tumors / epidemiology. Hospitals, University. Humans. Infant. Male. Middle Aged. Osteochondroma / diagnosis. Osteochondroma / epidemiology. Osteosarcoma / diagnosis. Osteosarcoma / epidemiology. Retrospective Studies. Thailand / epidemiology. World Health Organization

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  • (PMID = 16850677.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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86. Agrawal A, Rao KS, Makannavar JH, Shetty L, Patel N: Extracranial meningioma in the vicinity of the temporal bone: a difficult preoperative diagnosis. Surg Neurol; 2007 Jan;67(1):102-5
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  • [Title] Extracranial meningioma in the vicinity of the temporal bone: a difficult preoperative diagnosis.
  • BACKGROUND: Extracranial meningioma is a rare tumor, and most of the time only after histopathologic examination is diagnosis possible.
  • Incisional biopsy of the lesion was reported as spindle cell tumor.
  • Computed tomography scan showed large enhancing predominantly extracranial lesion located in the right anterior frontotemporal region extending into the infratemporal fossa and a relatively thin sheet of tumor on the intracranial aspect of the thickened temporal.
  • Intraoperative impression was malignant tumor involving the temporalis muscle, and a near total excision of the lesion was performed.
  • Histopathologic features were suggestive of meningothelial meningioma arising from the temporal bone with predominant extracranial extension.
  • CONCLUSION: Preoperative suspicion of a meningioma in this patient would have resulted in a more aggressive surgical approach as these lesions are relatively benign with indolent course.
  • [MeSH-major] Meningioma / pathology. Skull Neoplasms / pathology. Temporal Bone / pathology
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 17210319.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Lanza A, Laino L, Rossiello L, Perillo L, Ermo AD, Cirillo N: Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction. Open Dent J; 2008;2:73-7
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  • [Title] Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction.
  • Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph.
  • Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distinguishing benign tumours from their malign counterpart, although the radiographic aspect of the lesion is not always predictive.
  • Therefore a critical differential diagnosis has to be reached to choose the best management.
  • Here, we report a case of giant cell tumour (GCT) whose radiological features by computed tomography (CT) suggested the presence of bone malignancy, whereas the evaluation of a routine OPT scan comforted us about the benign nature of the lesion.
  • A brief review of the literature on such a benign but locally aggressive neoplasm is also provided.

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  • [Cites] Int J Pediatr Otorhinolaryngol. 2002 Sep 2;65(2):143-6 [12176185.001]
  • (PMID = 19088886.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2581533
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88. Harzallah L, Bouajina E, Rammeh N, Belhadj SK, Ghannouchi M, Kraiem C: [Iliac chondroma: a case report]. Tunis Med; 2005 Sep;83(9):578-80
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  • Chondroma is a benign bone tumour that usually occurs in the in carpal and phalangeal bones.
  • The diagnosis of chondroma was confirmed after surgical biopsy.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroma / pathology. Ilium / pathology

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  • (PMID = 16383207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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89. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7
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  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Arantes M, Resende M, Honavar M, Pires MM, Pereira JR, Vaz AR: Benign osteoblastoma of the sphenoid bone. Skull Base; 2009 Nov;19(6):437-41
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  • [Title] Benign osteoblastoma of the sphenoid bone.
  • Osteoblastoma is an uncommon benign bone tumor that accounts for 1% of all primary bone tumors.
  • Well documented in the spine and long bones, it is rarely found in the skull, namely in the sphenoid bone, with only five cases reported in the literature.
  • We report a case of an 11-year-old girl with a histologically confirmed benign osteoblastoma in an unusual location and an atypical aspect on the imaging studies.

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  • [Cites] Cancer. 1956 Sep-Oct;9(5):1044-52 [13364889.001]
  • (PMID = 20436846.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793891
  • [Keywords] NOTNLM ; Benign osteoblastoma / child / radical resection / sphenoid bone
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91. Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am; 2009 Aug;17(3):469-87, vi
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  • [Title] MR imaging of primary bone tumors and tumor-like conditions in children.
  • This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumorlike conditions encountered in the pediatric population.
  • Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma.
  • Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis.
  • The use of MR imaging in the diagnosis of these lesions is discussed, and the text is enhanced with imaging examples of the lesions.
  • [MeSH-major] Bone Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Bone Cysts / diagnosis. Bone Cysts / pathology. Cartilage Diseases / diagnosis. Cartilage Diseases / pathology. Child. Contrast Media. Humans

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  • (PMID = 19524197.001).
  • [ISSN] 1557-9786
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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92. Zegn W, Li G, Liu Z, Gao CH: [Bone morphogenetic protein compunds combined with autologous red bone marrow graft for treatment of benign bone tumors and tumor-like lesions in limbs]. Zhongguo Gu Shang; 2010 Oct;23(10):788-9
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  • [Title] [Bone morphogenetic protein compunds combined with autologous red bone marrow graft for treatment of benign bone tumors and tumor-like lesions in limbs].
  • [MeSH-major] Bone Marrow Transplantation / immunology. Bone Morphogenetic Proteins / therapeutic use. Bone Neoplasms / therapy. Combined Modality Therapy. Transplantation, Autologous / immunology

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  • (PMID = 21137298.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Morphogenetic Proteins
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93. Goto T, Maeshima A, Oyamada Y, Kato R: Definitive diagnosis of multiple myeloma from rib specimens resected at thoracotomy in a patient with lung cancer. Interact Cardiovasc Thorac Surg; 2010 Jun;10(6):1051-3
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  • [Title] Definitive diagnosis of multiple myeloma from rib specimens resected at thoracotomy in a patient with lung cancer.
  • Serum immunoelectrophoresis detected IgG-lambda monoclonal protein; therefore, we suspected the coexistence of multiple myeloma, amyloidosis, benign macroglobulinemia, or benign monoclonal gammopathy.
  • Since the patient continued to expectorate large amounts of bloody sputum every day, and his anemia progressed, right upper lobectomy and lymph node dissection were performed on a semi-emergent basis without preoperative bone marrow examination.
  • The postoperative pathological diagnosis was SCC of the lung (p-T2N0M0, stage IB).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Multiple Myeloma / diagnosis. Neoplasms, Multiple Primary. Ribs / pathology. Thoracotomy
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed


94. Bahamonde L, Catalan J: Bone tumors around the knee: risks and benefits of arthroscopic procedures. Arthroscopy; 2006 May;22(5):558-64
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  • [Title] Bone tumors around the knee: risks and benefits of arthroscopic procedures.
  • Although most primary bone tumors and soft tissue tumors arise around the knee joint, many patients with tumoral conditions attribute their symptoms to traumatic events.
  • Arthroscopy is the preferred method for diagnosis and treatment of knee joint disease, but even a minimally invasive procedure may have adverse consequences in the presence of an unsuspected neoplasm.
  • Arthroscopic biopsy and treatment are recommended for selected intra-articular tumors.
  • In addition, arthroscopy is a useful adjunct during surgical treatment of patients with certain juxta-articular benign bone tumors.
  • In this Current Concepts review, we consider the risks and benefits of arthroscopy in the presence of tumors about the knee joint.
  • [MeSH-major] Arthroscopy. Bone Neoplasms / surgery. Knee Joint
  • [MeSH-minor] Biopsy. Humans. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery

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  • (PMID = 16651168.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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95. Faik A, Mahfoud Filali S, Lazrak N, El Hassani S, Hajjaj-Hassouni N: Spinal cord compression due to vertebral osteochondroma: report of two cases. Joint Bone Spine; 2005 Mar;72(2):177-9
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  • Osteochondroma, or exostosis, is the most common of all benign bone tumors.

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  • (PMID = 15797501.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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96. Meyer A, Bastian L, Bruns F: Benign giant cell tumor of the spine: an unusual indication for radiotherapy. Arch Orthop Trauma Surg; 2006 Oct;126(8):517-21
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  • [Title] Benign giant cell tumor of the spine: an unusual indication for radiotherapy.
  • INTRODUCTION: Giant cell tumors are rare primary bone tumors.
  • CASE REPORT: We report about a 64-year-old female patient presenting with history of three osseous and one pulmonal manifestation of a benign giant cell tumor that have manifested metachronously within 23 years.
  • The two periphery bone and the one pulmonal manifestation were treated surgically with success.
  • Now, a further osseous lesion occurred at the seventh vertebra of the thoracic spine and was treated by dorsal instrumentation and replacement of the seventh vertebra.
  • Nine months later, local recurrence of this benign giant cell tumor developed at the thoracic spine and was treated with radiotherapy with a total dose of 45 Gy.
  • Due to neurological deficits a laminectomy and a stabilization of the destroyed sixth vertebra with bone cement was carried out.
  • Histopathological examination again showed benign giant cell tumor without suspicion of malignancy.
  • CONCLUSION: In the literature the use of radiation therapy remains an appropriate therapy option in benign giant cell tumors with minimal adverse sequelae if primary surgical treatment is not feasible or fails.
  • [MeSH-major] Giant Cell Tumor of Bone / radiotherapy. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16810546.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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97. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • We present a rare atypical lipomatous tumour with spindle cell features (synonym: well-differentiated spindle cell liposarcoma) arising on the left palm of a 54-year-old male patient.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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98. Hörmann M: [Neuroblastoma in children]. Radiologe; 2008 Oct;48(10):940-5
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  • Neuroblastomas have a very heterogenic clinical presentation, ranging from relatively benign forms with the potential of spontaneous regression, to foudroyant malignant forms.
  • Over half of neuroblastomas must be classified as high-risk tumors with a markedly high rate of recurrence.
  • Despite multidisciplinary therapeutic approaches, the survival rate of children with this type of tumor is still below 40%.
  • An ever-growing amount of data from international studies dating from the early 1970s onwards, points to the necessity of re-evaluating the medical approach in establishing the diagnosis and staging, understanding tumor biology and pathology, as well as therapy planning.
  • [MeSH-major] Bone Marrow Neoplasms / diagnosis. Brain Neoplasms / diagnosis. Magnetic Resonance Imaging. Neuroblastoma / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Age Factors. Child. Child, Preschool. Humans. Infant. Infant, Newborn. Life Expectancy. Mass Screening. Neoplasm Staging. Paraneoplastic Syndromes / diagnosis. Positron-Emission Tomography. Prognosis. Quality of Life. Risk Factors. Ultrasonography


99. Zissimopoulos A, Stellos K, Matthaios D, Petrakis G, Parmenopoulou V, Babatsikou F, Matthaiou E, Theodosiadou E, Hountis P, Koutis C: Type I collagen biomarkers in the diagnosis of bone metastases in breast cancer, lung cancer, urinary bladder cancer and prostate cancer. Comparison to CEA, CA 15-3, PSA and bone scintigraphy. J BUON; 2009 Jul-Sep;14(3):463-72
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  • [Title] Type I collagen biomarkers in the diagnosis of bone metastases in breast cancer, lung cancer, urinary bladder cancer and prostate cancer. Comparison to CEA, CA 15-3, PSA and bone scintigraphy.
  • PURPOSE: In this study we evaluated the clinical usefulness of serum pro-I collagen peptide (PICP) and I collagen telopeptide (ICTP) as indicators of early bone metastases in patients with breast (BC), lung (LC), urinary bladder (UBC) and prostate cancer (PC).
  • 145 had histologically confirmed BC (92 with bone metastases), 20 UBC (6 with bone metastases), 11 LC (3 with bone metastases) and 129 PC (68 with bone metastases).
  • In BC patients we compared the PICP and ICTP levels with those of CA 15-3, CEA and bone scintigraphy.
  • Patients with LC and UBC had PICP and ICTP measurements, PC patients had serum PICP, prostate specific antigen (PSA) measurements and bone scans.
  • RESULTS: ICTP and CA 15-3 levels were significantly higher in patients with BC and bone metastases in comparison to patients without metastases (p <0.05), while PICP and CEA were only marginally higher.
  • Significant correlation was observed between existence of bone metastases and ICTP levels (p <0.05).
  • ICTP and CA 15-3 were the most reliable markers for early diagnosis of bone metastases in BC.
  • Furthermore, PICP and PSA levels were significantly higher in patients with PC and bone metastases in comparison to patients with benign prostate hyperplasia (BPH) (p <0.0001) or in patients with PC without bone metastases (p <0.0005 for PICP and p <0.0001 for PSA).
  • In LC patients, ICTP levels differed significantly between patients with and without bone metastases (p=0.025).
  • In UBC patients, PICP levels differed significantly between patients with and without bone metastases (p=0.017).
  • CONCLUSION: ICTP and CA 15-3 are the most reliable markers for early diagnosis of bone metastases in BC patients.
  • PICP could be useful for diagnosing early bone metastases of PC and combined with PSA and bone scan can be an additional tool in the follow-up of PC patients.
  • For LC patients, ICTP showed a significant difference in the discrimination of patients with and without bone metastases.
  • In UBC patients, PICP showed a significant difference in the discrimination of patients with and without bone metastases.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Collagen Type I / metabolism
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / pathology. Carcinoembryonic Antigen / metabolism. Female. Humans. Immunoradiometric Assay. Lung Neoplasms / pathology. Male. Middle Aged. Mucin-1 / metabolism. Neoplasm Metastasis. Prostate-Specific Antigen / metabolism. Prostatic Neoplasms / pathology. Sensitivity and Specificity. Tomography, Emission-Computed. Urinary Bladder Neoplasms / pathology


100. Xu J, Xu CR, Wu H, Pan HL, Tian J: Osteochondroma in the lumbar intraspinal canal causing nerve root compression. Orthopedics; 2009 Feb;32(2):133
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  • Osteochondromas, which are benign bone tumors that usually develop on long bones, tubular bones, are rarely found in the spine.
  • Considering differential diagnosis, lumbar facet synovial cysts must be excluded as they can also cause myeloradiculopathy with the similar mechanism.
  • The tumor, approximately 6x7x11 mm, was identified after laminectomy of the L5 laminae.
  • Postoperative histopathologic examination confirmed our hypothesis of benign osteochondroma.
  • Computed tomography and MRI are helpful for the preoperatively precise indication of tumor extent and its relationships with the adjacent.

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  • (PMID = 19301786.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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