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1. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Non-specificity of clinical and radiological features of these maxillary lesions makes their diagnosis difficult.
  • The awareness of the spectrum of pathology related to maxillary swelling is essential for correct diagnosis and treatment.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Fibrous Dysplasia of Bone / complications. Humans. Male. Middle Aged. Mucocele / complications. Nasal Obstruction / complications. Odontogenic Cysts / complications. Preoperative Care. Prospective Studies. Young Adult

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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2. Franceschi F, Marinozzi A, Rizzello G, Papalia R, Rojas M, Denaro V: Computed tomography-guided and arthroscopically controlled en bloc retrograde resection of a juxta-articular osteoid osteoma of the tibial plateau. Arthroscopy; 2005 Mar;21(3):351-9
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  • Osteoid osteoma represents approximately 10% to 11% of all the benign bone tumors.
  • The lesion was removed by a rear-entry computed tomography (CT)-guided drill under arthroscopic control and the bony defect filled with bone graft harvested from the proximal tibial metaphysis.
  • The follow-up CT scan 2 years after surgery showed complete excision of the lesion and perfect positioning of the bone graft.
  • [MeSH-major] Arthroscopy / methods. Bone Neoplasms / surgery. Knee Joint / surgery. Osteoma, Osteoid / radiography. Osteoma, Osteoid / surgery. Tibia / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 15756191.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Sadeghi-Azandaryani M, Mendl N, Rademacher A, Hoffmann U, Steckmeier B, Heyn J: Pseudoaneurysm of the popliteal artery due to osteochondroma of the distal femur. Vasa; 2010 Aug;39(3):274-7
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  • Osteochondroma is the most common type of benign bone tumour, and is most often found in the knee region.
  • The lesion is usually clinically silent although it may cause different complications such as fractures of the tumour, bone deformities, neurological disorders, malignant transformation and in rare cases vascular disorders.
  • A delay in diagnosis especially of pseudoaneurysm formation may result in life-threatening situations, extensive operations and lengthy hospital stays.

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  • (PMID = 20737389.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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4. Geniets C, Vanhoenacker FM, Van de Perre S, Van Dyck P, Gielen J, De Schepper AM, Parizel PM: Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features. JBR-BTR; 2006 Sep-Oct;89(5):266-74
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  • [Title] Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features.
  • Benign bone lesions are a fairly common finding in radiology practice.
  • Often, the combination of patient's age and plain radiographic findings are sufficient for diagnosis and obviates the need for further imaging.
  • Generally the following parameters should be assessed in the evaluation of a bone lesion: clinical features, age of the patient, location, size, pattern of bone destruction, cortical involvement, zone of transition, sclerotic margination and matrix calcification.
  • This article reviews the spectrum of clinical and imaging appearances of the most common benign bone tumors.
  • [MeSH-major] Bone Diseases / diagnosis. Bone Neoplasms / diagnosis. Magnetic Resonance Imaging. Radiology. Societies, Medical. Tomography, X-Ray Computed
  • [MeSH-minor] Bone and Bones / pathology. Humans

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  • (PMID = 17147017.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Belgium
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5. Güvenç BH, Etus V, Muezzinoglu B: Lumbar teratoma presenting intradural and extramedullary extension in a neonate. Spine J; 2006 Jan-Feb;6(1):90-3
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  • The mass contained an irregular, bone-like, hard and mobile material accompanying cystic components.
  • Total removal of the tumor was achieved.
  • The pathological examination showed a benign teratoma containing mature cartilage, muscle, adipose tissue, and glandular tissue.
  • CONCLUSION: Accompanying a spinal dysraphic state, the mature teratoma in our case may support the idea of a tumor actually arising from a dysraphism and growing outward to produce the mass.
  • [MeSH-major] Lumbar Vertebrae. Neoplasm Invasiveness / pathology. Spinal Cord Neoplasms / diagnosis. Spinal Neoplasms / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Infant, Newborn. Magnetic Resonance Imaging. Neoplasm Staging. Neurosurgical Procedures / methods. Recovery of Function. Risk Assessment

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  • (PMID = 16413454.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Ayerza MA, Muscolo DL, Aponte-Tinao LA, Farfalli G: Effect of erroneous surgical procedures on recurrence and survival rates for patients with osteosarcoma. Clin Orthop Relat Res; 2006 Nov;452:231-5
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  • Nine patients had intralesional curettage performed at other institutions based on an erroneous diagnosis of a benign lesion.
  • Response to adjuvant therapy and the amount of previous violation of natural tumor barriers should be evaluated carefully before deciding surgical treatment.
  • [MeSH-major] Bone Neoplasms / mortality. Bone Neoplasms / surgery. Medical Errors. Neoplasm Recurrence, Local / epidemiology. Osteosarcoma / mortality. Osteosarcoma / surgery

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  • (PMID = 16906060.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Morimoto O, Nagano H, Miyamoto A, Fujiwara Y, Kondo M, Yamamoto T, Ota H, Nakamura M, Wada H, Damdinsuren B, Marubashi S, Dono K, Umeshita K, Nakamori S, Sakon M, Monden M: Association between recurrence of hepatocellular carcinoma and alpha-fetoprotein messenger RNA levels in peripheral blood. Surg Today; 2005;35(12):1033-41
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  • PURPOSE: Intra- and extrahepatic recurrence is common, even after curative resection for hepatocellular carcinoma (HCC), suggesting preoperative or intraoperative tumor cell dissemination.
  • METHODS: We prospectively examined peripheral blood samples from 38 patients with HCC, and bone marrow aspirate from 25 of these patients.
  • As a control, we examined bone marrow from 20 patients with benign diseases.
  • Bone marrow samples were defined as positive if they expressed AFP mRNA at levels higher than the maximum expressed level in the controls, because only 1 (5%) of the 20 control bone marrow samples had low AFP mRNA expression.
  • The results of bone marrow RT-PCR did not correlate with the clinocopathological characteristics of prognosis.
  • CONCLUSIONS: Using real-time PCR to measure the AFP mRNA level in blood, but not bone marrow, could be useful for predicting postoperative tumor recurrence.
  • [MeSH-major] Carcinoma, Hepatocellular / blood. Liver Neoplasms / blood. Neoplasm Recurrence, Local / blood. RNA, Messenger / blood. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Adult. Aged. Bone Marrow / metabolism. Case-Control Studies. Chi-Square Distribution. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Polymerase Chain Reaction. Prognosis. Prospective Studies. Statistics, Nonparametric

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  • (PMID = 16341483.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / alpha-Fetoproteins
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8. Dhillon MS, Prasad P: Multicentric giant cell tumour of bone. Acta Orthop Belg; 2007 Jun;73(3):289-99
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  • [Title] Multicentric giant cell tumour of bone.
  • Although giant cell tumour (GCT) is seen quite frequently, multicentric giant cell tumour (MCGCT) is a rare entity occurring in less than 1% of patients with GCT.
  • The pathogenesis of MCGCT is debated; various mechanisms have been postulated, including contiguous spread, iatrogenic tumour cell seeding, benign metastasis, malignant transformation and de novo formation.
  • [MeSH-major] Bone Neoplasms. Giant Cell Tumor of Bone
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 17715717.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 77
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9. Lin O, Crapanzano JP: Fine-needle aspiration cytology of pleomorphic hyalinized angiectatic tumor: A case report. Diagn Cytopathol; 2005 Apr;32(4):238-42
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  • [Title] Fine-needle aspiration cytology of pleomorphic hyalinized angiectatic tumor: A case report.
  • Pleomorphic hyalinized angiectatic tumor (PHAT) of soft parts is a neoplasm characterized by spindle and pleomorphic cells associated with an angiectatic vasculature.
  • The differential diagnosis include solitary fibrous tumor (SFT) and ancient schwannoma, which also shows fibrous-like material and spindle cells that may have intranuclear inclusions.
  • [MeSH-major] Bone Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Knee / pathology. Neurilemmoma / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754361.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Cudney N, Ochs MW, Johnson J, Roccia W, Collins BM, Costello BJ: A unique presentation of a squamous cell carcinoma in a pregnant patient. Quintessence Int; 2010 Jul-Aug;41(7):581-3
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  • This report discusses the diagnosis and treatment of this unusual scenario involving progression of a benign lesion to a malignant hybrid.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Verrucous / diagnosis. Mandibular Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Bone Transplantation. Female. Follow-Up Studies. Humans. Mandibular Diseases / diagnosis. Neoadjuvant Therapy. Neoplasm Staging. Odontogenic Cysts / diagnosis. Pregnancy. Reconstructive Surgical Procedures. Skin Transplantation

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  • (PMID = 20614045.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Johann AC, de Freitas JB, de Aguiar MC, de Araújo NS, Mesquita RA: Peripheral osteoma of the mandible: case report and review of the literature. J Craniomaxillofac Surg; 2005 Aug;33(4):276-81
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  • BACKGROUND: Osteoma is a benign often asymptomatic neoplasm, consisting of well-differentiated mature bone.
  • CONCLUSION: The peripheral type of osteoma is most common in the lower jaws, occurs at the surface of the cortical bone and is sessile or pedicled.

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  • (PMID = 15979316.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Scotland
  • [Number-of-references] 59
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12. Fritsche-Guenther R, Gruetzkau A, Noske A, Melcher I, Schaser KD, Schlag PM, Kasper HU, Krenn V, Sers C: Therapeutic potential of CAMPATH-1H in skeletal tumours. Histopathology; 2010 Dec;57(6):851-61
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  • [Title] Therapeutic potential of CAMPATH-1H in skeletal tumours.
  • The aim of this study was to analyse tissue and cell lines of non-neoplastic bone, cartilage and skeletal tumours for CD52 expression.
  • Malignant tumours showed higher CD52 expression compared to benign tumours, suggesting a role in the development and progression of bone tumours.
  • Interestingly, immunohistochemistry and flow cytometry revealed that CD52 was expressed not only on the surface of tumour cells, but also in the cytoplasm.
  • CONCLUSION: CD52 is expressed in a variety of bone tumours and the in vitro studies presented herein suggest that CAMPATH-1H treatment might have therapeutic potential for osteosarcoma patients.
  • [MeSH-major] Antibodies, Monoclonal / pharmacology. Antibodies, Neoplasm / pharmacology. Antigens, CD / immunology. Antigens, Neoplasm / immunology. Antineoplastic Agents / pharmacology. Bone Neoplasms / immunology. Bone and Bones / immunology. Chondroma / immunology. Glycoproteins / immunology. Sarcoma / immunology

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21166699.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antibodies, Neoplasm; 0 / Antigens, CD; 0 / Antigens, Neoplasm; 0 / Antineoplastic Agents; 0 / CD52 antigen; 0 / Glycoproteins; 3A189DH42V / alemtuzumab
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13. Shirani G, Arshad M, Mohammadi F: Immediate reconstruction of a large mandibular defect of locally invasive benign lesions (a new method). J Craniofac Surg; 2007 Nov;18(6):1422-8
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  • [Title] Immediate reconstruction of a large mandibular defect of locally invasive benign lesions (a new method).
  • Locally invasive benign tumor and large lesions such as ameloblastoma, giant cell granuloma, odontogenic keratocyst, and odontogenic myxoma are a benign, invasive, lesions of the jaws that predominantly affects the mandible.
  • Despite the benign nature of these lesions, there is a high rate of local recurrence after curettage, which usually requires resection.
  • This approach represents a less invasive alternative that provides access to the mandible for curative resection of benign tumors with minimal postoperative sequelae.
  • [MeSH-minor] Adolescent. Adult. Bone Plates. Bone Transplantation. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17993894.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Moh EN, Aguehoundé C, Aké YL, Kéita A, Kotaix L: [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child]. Mali Med; 2010;25(1):64-5
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  • [Title] [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child].
  • [Transliterated title] Reconstruction par Fibula non Vascularisee d'un Kyste Osseux Anevrysmal de L'Humerus Chez L'Enfant.
  • Aneurysmal bone cyst is a pseudotumoral bone dystrophy which accounts for 1.5 to 4% of benign bone tumours.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Fibula / transplantation. Humerus / surgery

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  • (PMID = 21436008.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mali
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15. Prasad K, Rao SG, Harish K: Giant cell tumor of the temporal bone--a case report. BMC Ear Nose Throat Disord; 2005 Sep 15;5:8
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  • [Title] Giant cell tumor of the temporal bone--a case report.
  • BACKGROUND: Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull.
  • The petrous portion of the temporal bone forms a rare location for this tumor.
  • CASE PRESENTATION: The authors report a case of a large giant cell tumor involving the petrous and squamous portions of the temporal bone in a 26 year old male patient.
  • Radical excision of the tumor was achieved but facial palsy could not be avoided.
  • CONCLUSION: Radical excision of skull base giant cell tumor may be hazardous but if achieved is the optimal treatment and may be curative.

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  • [Cites] J Oral Maxillofac Surg. 2004 Jan;62(1):116-8 [14733232.001]
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  • (PMID = 16162299.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1253509
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16. Zhang C, Cui GH, Liu F, Wu QL, Chen Y: [The role of stromal cell derived factor-1/CXCR4 biological axis in tumor metastasis of non-Hodgkin lymphoma]. Zhonghua Yi Xue Za Zhi; 2007 Mar 13;87(10):695-7
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  • [Title] [The role of stromal cell derived factor-1/CXCR4 biological axis in tumor metastasis of non-Hodgkin lymphoma].
  • OBJECTIVE: To study the expression of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 in non-Hodgkin lymphoma (NHL), and to investigate the role of this biological axis in tumor metastasis of NHL.
  • METHODS: Specimens of bone marrow were collected from 4 patients with NHL with bone marrow infiltration and 4 cases of NHL without bone marrow infiltration, and 4 patients with benign hepatopathy with normal myelogram.
  • The level of SDF-1alpha mRNA in the stromal cells of bone marrow and lymph node were determined by RT-PCR.
  • The CXCR4 expression on lymphoma cells freshly isolated from bone marrow and lymph node of the NHL patients were studied by flow cytometry.
  • Transwell assay was performed, the upper chamber being added with suspension of cells newly isolated from lymph nodes or bone marrow undergoing co-incubation with ant-CXCR4 monoclonal antibody or not, and the lower chamber added with culture fluid with or without recombinant human SDF-1alpha (rhSDF-1alpha).
  • RESULTS: The expression levels of CXCR4 on the lymphoma cells isolated from the bone marrow involved or not involved by NHL were both significantly higher than that of the mononuclear cells from normal bone marrow (both P < 0.01), whereas the CXCR4 expression level on the lymphoma cells from the lymph nodes of the NHL patients was also significantly higher than that of the mononuclear cells from the lymph nodes of reactive proliferative lymphadenitis (P < 0.01).
  • The SDF-1alpha mRNA expression level in the stromal cells isolated from the bone marrow involved by NHL was significantly higher than those of the stromal cells of bone marrow not involved by NHL and the normal bone marrow (both P < 0.01).
  • CONCLUSION: SDF-1/CXCR4 axis plays a uniquely important biological role in mediating tumor metastasis of NHL.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Flow Cytometry. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17553309.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chemokine CXCL12; 0 / RNA, Messenger; 0 / Receptors, CXCR4
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17. Buchner M, Bernd L, Zahlten-Hinguranage A, Sabo D: [Bone and soft-tissue tumors of the foot and ankle]. Chirurg; 2005 Apr;76(4):391-7
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  • [Title] [Bone and soft-tissue tumors of the foot and ankle].
  • [Transliterated title] Knochen- und Weichteiltumoren des Fusses und Sprunggelenkes Epidemiologie, Versorgungsstrategie und klinisch-funktionelle Ergebnisse nach operativer Therapie.
  • BACKGROUND: This study reports the epidemiology of bone and soft-tissue tumors of the foot and ankle, presents therapy strategies, and evaluates mid-term clinicofunctional outcome after surgery for malignant tumors.
  • METHODS: Two hundred four patients with tumors of the foot and ankle were analyzed (163 benign and 41 malignant).
  • RESULTS: The most frequent tumors were exostosis, bone cyst, and osteoid osteoma for benign tumors and metastases and chondrosarcoma and Ewing's sarcoma for malignant tumors.
  • In more than 90% of the benign tumors, local resection could be carried out, whereas in malignant tumors, ablative procedures and arthrodeses were almost as common as limb- and joint-sparing techniques.
  • However, follow-up revealed good functional results and a 5-year survival rate of 84% for patients with primary malignant tumors.
  • CONCLUSION: Tumors of the foot and ankle require a thorough therapeutic strategy.
  • [MeSH-major] Ankle Joint / surgery. Bone Neoplasms / surgery. Foot / surgery. Foot Diseases / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Amputation. Arthrodesis. Bone Transplantation. Child. Child, Preschool. Female. Follow-Up Studies. Fracture Fixation, Internal. Fractures, Spontaneous / diagnosis. Fractures, Spontaneous / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 15526178.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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18. Li BJ, Wang JY, Wang HY, Huang XP, Zhang LJ, Long H, Yang MT, Rong TH: [Clinical significance of hMAM mRNA detection in bone marrow of breast carcinoma patient]. Zhonghua Zhong Liu Za Zhi; 2006 Oct;28(10):766-9
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  • [Title] [Clinical significance of hMAM mRNA detection in bone marrow of breast carcinoma patient].
  • OBJECTIVE: To investigate the expression of the human mammoglobin (hMAM) mRNA in bone marrow and its clinical significance in the breast cancer patient.
  • METHODS: Expression of hMAM mRNA was detected using nested reverse transcription polymerase chain reaction (RT-PCR) in the bone marrow aspiration sample from 75 breast cancer patients, 15 patients with benign breast lesions and 8 healthy volunteers as control.
  • However, hMAM mRNA expression was not detected in the bone marrow aspiration samples from patients with benign breast lesions and healthy volunteers.
  • The hMAM mRNA expression was positively correlated with axillary nodal involvement and progesterone receptor (PR) status (P < 0.05) as well as Ki67 expression in breast cancer tissue (chi2 = 4.936, P = 0.026), but not with age, tumor size, clinical stage, or estrogen receptor (ER) status (P > 0.05).
  • CONCLUSION: RT-PCR is quite sensitive and has a high specificity in detecting the presence of hMAM mRNA in the bone marrow from breast cancer patients.
  • Thereupon, hMAM mRNA may be useful as a molecular biomarker in detecting disseminated tumor cells (DTC) in the bone marrow of breast cancer patients.
  • [MeSH-major] Bone Marrow / metabolism. Breast Neoplasms / genetics. Breast Neoplasms, Male / genetics. Neoplasm Proteins / genetics. Uteroglobin / genetics
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / genetics. Breast / metabolism. Breast / pathology. Carcinoma, Ductal, Breast / genetics. Carcinoma, Ductal, Breast / pathology. Female. Fibroadenoma / genetics. Fibroadenoma / pathology. Humans. Ki-67 Antigen / genetics. Lymphatic Metastasis. Male. Mammaglobin A. Middle Aged. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Receptors, Progesterone / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17366790.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mammaglobin A; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Receptors, Progesterone; 0 / SCGB2A2 protein, human; 9060-09-7 / Uteroglobin
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19. Saglik Y, Altay M, Unal VS, Basarir K, Yildiz Y: Manifestations and management of osteochondromas: a retrospective analysis of 382 patients. Acta Orthop Belg; 2006 Dec;72(6):748-55
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  • Osteochondromas represent the most common primary bone tumours; they reportedly represent 20-50% of all benign bone tumours and 10-15% of all bone tumours.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Osteochondroma / diagnosis. Osteochondroma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Exostoses, Multiple Hereditary / complications. Exostoses, Multiple Hereditary / diagnosis. Exostoses, Multiple Hereditary / surgery. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17260614.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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20. Mackenzie H, Gulati V, Tross S: A rare case of a swollen knee due to disseminated synovial chondromatosis: a case report. J Med Case Rep; 2010;4:113
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  • INTRODUCTION: A synovial chondromatosis is a rare benign neoplasm on the synovium.
  • Although described as a benign disease, it can be very destructive and can cause severe osteoarthritis and pain.
  • CONCLUSIONS: Although synovial chondromatosis is described as a benign disease, it can be very destructive and debilitating.

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  • [Cites] J Arthroplasty. 2008 Apr;23(3):395-400 [18358378.001]
  • [Cites] J Bone Joint Surg Am. 1973 Dec;55(8):1747-8 [4804995.001]
  • [Cites] J Bone Joint Surg Am. 2007 Jun;89(6):1321-8 [17545437.001]
  • (PMID = 20416049.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2873448
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21. George B, Archilli M, Cornelius JF: Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases. Acta Neurochir (Wien); 2006 Jul;148(7):741-9; discussion 749
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  • [Title] Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases.
  • BACKGROUND: Bone tumors located at the cranio-cervical junction (CCJ)are rare.
  • Tumoral involvement of the neighbouring structures including bone, nerves and vertebral artery and the dynamic aspects of the bone structures raise technical difficulties in the surgical approach.
  • METHODS: Forty-one patients presenting a bone tumor (26 benign and 15 malignant tumors), excluding chordomas, located at the CCJ (including lower third of the clivus, C1 and C2) were observed over 20 years from 1981 to 2001.
  • Imaging work-up included CT scanner with bone windows sequences and reconstruction in the coronal and sagittal plane; since 1984 most of the patients (N=35) underwent a MRI and angioMR scanning.
  • Vertebral angiography was rarely performed (N=9) and mostly when the diagnosis was doubtful.
  • In some cases the diagnosis was clear but in others, imaging studies showed destructive lesions suggesting a malignancy, which sometimes required a biopsy (N=4).
  • A complementary stabilization procedure was necessary in 18 cases using either bone grafting during the same procedure and through the same approach (N=5) or a craniocervical plating and bone grafting (N=13).
  • No recurrence in the group of benign tumors was seen during an average follow-up of 6 years (from 2 to 11 years).
  • CONCLUSIONS: Various types of bone tumors may be found at the CCJ.
  • Confusion between benign and malignant tumor or pseudo tumors must be avoided, sometimes requiring a biopsy.
  • [MeSH-major] Axis, Cervical Vertebra / surgery. Bone Neoplasms / surgery. Cervical Atlas / surgery. Neurosurgical Procedures / methods. Occipital Bone / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebral Angiography. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neck Pain / etiology. Neck Pain / physiopathology. Neck Pain / surgery. Neoplasm Metastasis / pathology. Neoplasm Metastasis / radiography. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Retrospective Studies. Spinal Fusion. Tomography, X-Ray Computed. Treatment Outcome. Vertebral Artery / anatomy & histology. Vertebral Artery / pathology. Vertebral Artery / surgery

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  • (PMID = 16708168.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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22. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • [Title] Tumors for the general orthopedist: how to save your patients and practice.
  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Faitaroni LA, Bueno MR, De Carvalhosa AA, Bruehmueller Ale KA, Estrela C: Ameloblastoma suggesting large apical periodontitis. J Endod; 2008 Feb;34(2):216-9
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  • After the initial endodontic treatment, continued expansion of the mandible cortical bone was observed, indicating a need to surgically enucleate the lesion and submit it for histopathologic examination.
  • The microscopic examination indicated a diagnosis of ameloblastoma.
  • Ameloblastoma is a benign epithelial neoplasm of odontogenic origin, and depending on the stage of development, it can mimic a periapical lesion and therefore should be considered in establishing an endodontic differential diagnosis.
  • The definitive diagnosis for some periapical lesions can only be made by a histopathologic examination.
  • [MeSH-major] Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis. Periapical Periodontitis / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Follow-Up Studies. Humans. Male. Mandibular Diseases / diagnosis. Middle Aged. Root Canal Therapy

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  • (PMID = 18215686.001).
  • [ISSN] 0099-2399
  • [Journal-full-title] Journal of endodontics
  • [ISO-abbreviation] J Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Tsai CY, Wei FC, Chang YL, Chen YY, Chen CT: Vastus lateralis muscle flap used for reconstruction of the maxilla after radical resection of recurrent ameloblastoma. Chang Gung Med J; 2006 May-Jun;29(3):331-5
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  • Maxillary ameloblastoma is a benign odontogenic neoplasm.
  • Simultaneous reconstruction was performed with an iliac crest bone graft for the orbital floor, and a vastus lateralis muscle flap for obliteration of the maxillary sinus and repair the oral and nasal cavities.
  • The conventional iliac bone graft supported by a well vascularized muscle eventually survived and provided a good functional and cosmetic result.
  • [MeSH-major] Ameloblastoma / surgery. Maxilla / surgery. Maxillary Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Surgical Flaps

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  • (PMID = 16924896.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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25. Nguyen QH, Szeto E, Mansberg R, Mansberg V: Paravertebral infection (phlegmon) demonstrated by FDG dual-head coincidence imaging in a patient with multiple malignancies. Clin Nucl Med; 2005 Apr;30(4):241-3
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  • A 66-year-old woman was referred for a bone scan to assess back pain on a background of breast cancer, melanoma, and rheumatic heart disease.
  • The scan appearance was suspicious for a localized soft tissue neoplasm.
  • Because FDG is not tumor-specific, accumulation in benign lesions may give rise to false-positive results despite a high pretest probability for malignancy.
  • [MeSH-minor] Aged. Back Pain / diagnosis. Back Pain / etiology. Breast Neoplasms / complications. Breast Neoplasms / radionuclide imaging. Diagnosis, Differential. Female. Gamma Cameras. Humans. Melanoma / complications. Melanoma / radionuclide imaging. Radiopharmaceuticals

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  • (PMID = 15764879.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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26. Simonetti S, Mignogna C, La Mantia V, Lanza F, Insabato L: Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report. Tumori; 2009 Jan-Feb;95(1):101-3
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  • [Title] Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report.
  • Intraosseous cavernomas are very rare benign lesions representing less than 1% of all skeletal tumors and most frequently observed in vertebrae and head and neck bones.
  • We report a case of this neoplasm in the distal epiphysis of the third metacarpal bone in a 68-year-old man, along with the clinicopathological findings.
  • The differential diagnosis and a review of the literature are discussed.
  • [MeSH-major] Bone Neoplasms / pathology. Hemangioma, Cavernous / pathology. Metacarpal Bones / pathology

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  • (PMID = 19366066.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Vallicioni J, Loum B, Dassonville O, Poissonnet G, Ettore F, Demard F: [Ameloblastomas]. Ann Otolaryngol Chir Cervicofac; 2007 Sep;124(4):166-71
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  • OBJECTIVES: The aim of this work was to report on the clinical, radiological and histological characteristics of ameloblastomas concerning bone structures of the face, rare but not exceptional tumours, and to communicate our experience of their treatment.
  • The diagnostic context, the treatment and the development of the disease are given in detail, emphasizing the frequency of local relapse of this histologically benign condition.
  • The frequency of local relapse in the cases of close resection, leaving in place micro-foci, justifies enlarged intervention, which is often bone destructive.
  • CONCLUSION: When the continuity of the bone is interrupted, in particular at the level of the mandible, and if the general condition of the patient permits, repair is preferable.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17673157.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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28. Jawad MU, Scully SP: In brief: classifications in brief: enneking classification: benign and malignant tumors of the musculoskeletal system. Clin Orthop Relat Res; 2010 Jul;468(7):2000-2
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  • [Title] In brief: classifications in brief: enneking classification: benign and malignant tumors of the musculoskeletal system.
  • [MeSH-major] Bone Neoplasms / classification. Muscle Neoplasms / classification. Musculoskeletal System / pathology
  • [MeSH-minor] Humans. Neoplasm Metastasis. Neoplasm Staging

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  • (PMID = 20333492.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2882012
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29. Li BJ, Huang XP, Wei WD, Wang JY, Su XD, Zhang X, Hong WS, Tang J, Zhang LJ, Long H, Yang MT, Rong TH: [Expression and clinical significance of cytokeratin 19 in bone marrow of patients with breast cancer]. Ai Zheng; 2005 Jun;24(6):735-9
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  • [Title] [Expression and clinical significance of cytokeratin 19 in bone marrow of patients with breast cancer].
  • Distant metastasis, especially bone metastasis, may influence prognosis of breast cancer patients.
  • Bone marrow micrometastasis (BMM) is difficult to detect with routine methods.
  • This study was designed to evaluate expression and clinical significance of cytokeratin 19 (CK19) in bone marrow of patients with breast cancer.
  • METHODS: Expression of CK19 mRNA in bone marrows of 65 breast cancer patients, 15 benign breast disease patients, and 8 healthy volunteers was detected by reverse transcription-polymerase chain reaction (RT-PCR).
  • RESULTS: Positive rate of CK19 mRNA was 33.8% in the 65 breast cancer patients, and 0 in both benign breast disease patients and healthy volunteers.
  • Expression of CK19 mRNA was positively correlated with tumor size and clinical stage (P < 0.05), but was not related to age and lymph node status (P > 0.05).
  • CONCLUSIONS: CK19 mRNA may be used as a molecular marker to detect bone marrow micrometastasis in patients with breast cancer.
  • [MeSH-major] Bone Marrow / metabolism. Breast Neoplasms / metabolism. Carcinoma, Ductal, Breast / metabolism. Keratin-19 / biosynthesis
  • [MeSH-minor] Adult. Aged. Breast Neoplasms, Male / metabolism. Breast Neoplasms, Male / pathology. Carcinoembryonic Antigen / blood. Female. Fibroadenoma / blood. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / biosynthesis. RNA, Messenger / genetics

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  • (PMID = 15946491.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / RNA, Messenger
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30. Papachristou DJ, Goodman MA, Cieply K, Hunt JL, Rao UN: Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis. Hum Pathol; 2006 Jul;37(7):890-8
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  • [Title] Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis.
  • Chondroblastoma (CBL) is a benign neoplasm of bone for which the genomic characteristics remain unclear.
  • Tumors were subjected to microdissection and polymerase chain reaction using 17 markers located near genes on chromosomes 5, 9, 11, 13, 17, and 19.
  • Fluorescence in situ hybridization was also performed on tumors displaying allelic losses, with dual-color probes for 9p, 17p, and 13q.
  • Loci with LOH in both tumor types suggest possible involvement of the genes p53, RB1, CDKN2/p16, ERC, and XRCC in tumorigenesis.
  • The role of p53 in CBL is uncertain; however, given the benign behavior of this tumor, it is probably unrelated to tumor progression.
  • [MeSH-major] Bone Neoplasms / genetics. Chondroblastoma / genetics. Chondrosarcoma / genetics. In Situ Hybridization, Fluorescence. Loss of Heterozygosity


31. Cueva del Castillo JF, Francisco Osuna J, Elizondo F, Pérez O, Pérez A, Hernández S, Mejía C: [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report]. Acta Ortop Mex; 2007 Jan-Feb;21(1):31-6
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  • [Title] [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report].
  • [Transliterated title] Aplicación de xenoimplante para el tratamiento de defectos oseos, tumores benignos, seudoartrosis y artrodesis. (Reporte preliminar).
  • OBJECTIVE: To show that the ceramic produced at the Institute for Materials Research, National Autonomous University of Mexico, is an appropriate replacement of bone graft in patients with bone tumors, benign tumors, pseudoarthrosis and arthrodesis treated at "General Ignacio Zaragoza" Regional Hospital.
  • They underwent X-ray evaluation of bone healing using the Montoya classification.
  • The most frequent indication was arthrodesis in 10 patients (45.45%), pseudoarthrosis in 6 (27.27%), benign tumors in 3 (13.63%), and bone defects in 3 (13.63%).
  • Type II to type IV bone healing was observed in the sample.
  • DISCUSSION: The use of ceramic xenoimplants is appropriate as a replacement of bone graft in patients with arthrodesis and bone defects, thus avoiding the need for autologous bone graft.
  • [MeSH-major] Arthrodesis. Bone Neoplasms / surgery. Bone Transplantation. Pseudarthrosis / surgery. Transplantation, Heterologous

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  • (PMID = 17695206.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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32. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Atalar B, Miller RC, Dincbas FO, Geismar JH, Micke O, Akyurek S, Ozyar E: Adult langerhans cell histiocytosis of bones : a rare cancer network study. Acta Orthop Belg; 2010 Oct;76(5):663-8
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  • Langerhans Cell Histiocytosis (LCH) is an uncommon benign bone tumour typically seen in children.
  • The localization of tumours was skull bones in 12 (40%), lower extremity in 6 (20%), thoracic bones in 4 (133%), spine in 3 (10%), pelvis in 2 (6.7%) and multiple sites in 3 (10%) patients.
  • [MeSH-major] Bone Diseases / therapy. Histiocytosis, Langerhans-Cell / therapy


34. Forsyth RG, De Boeck G, Bekaert S, De Meyer T, Taminiau AH, Uyttendaele D, Roels H, Praet MM, Hogendoorn PC: Telomere biology in giant cell tumour of bone. J Pathol; 2008 Apr;214(5):555-63
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  • [Title] Telomere biology in giant cell tumour of bone.
  • Giant cell tumour of bone (GCTB) is a benign bone tumour known for the unpredictable clinical behaviour of recurrences and, in rare instances, distant metastases.
  • GCTB has often been regarded as a polyclonal tumour, but more recently a recurrent specific aberration was reported, which suggests a possible role for disturbed telomere maintenance.
  • [MeSH-major] Bone Neoplasms / genetics. Giant Cell Tumors / genetics. Telomere / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Humans. In Situ Hybridization, Fluorescence. Male. Microscopy, Confocal. Middle Aged. Neoplasm Proteins / metabolism. Nuclear Proteins / metabolism. Osteoclasts / metabolism. Osteoclasts / pathology. Phosphoproteins / metabolism. RNA-Binding Proteins / metabolism. Telomerase / metabolism. Transcription Factors / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland
  • (PMID = 18278785.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / nucleolin; 143220-95-5 / PML protein, human; EC 2.7.7.49 / Telomerase
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35. Harimaya A, Tsubota H, Hoki K, Sato J, Kondo A, Yamada T, Seki N, Ikeda H, Himi T: Ossifying fibroma of the mandible with primary hyperparathyroidism due to non-familial parathyroid adenoma. J Laryngol Otol; 2007 Mar;121(3):281-4
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  • Ossifying fibroma is an uncommon benign osteogenic neoplasm arising from cells of the periodontal ligament, typically with a slowly progressive enlargement of the affected bone.
  • The neoplasm sometimes presents with hyperparathyroidism, most of which cases are due to familial parathyroid tumours.
  • Despite improvement of parathyroid dysfunction after removal of the parathyroid adenoma, the tumour continued to grow very aggressively.
  • The case required partial mandibular resection for complete resection of the tumour, and fixation of the remaining mandible with a titanium plate.
  • [MeSH-major] Adenoma / diagnosis. Fibroma, Ossifying / diagnosis. Hyperparathyroidism, Primary / etiology. Mandibular Neoplasms / diagnosis. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Humans. Male. Neoplasms, Multiple Primary / diagnosis


36. von Falck C, Rosenthal H, Gratz KF, Galanski M: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med; 2007 Aug;32(8):640-2
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  • However, findings in the coregistered CT scan were consistent with nonossfiying fibroma, a common benign skeletal lesion.
  • Combined PET/CT imaging can be helpful to identify benign bone lesions mimicking metastatic or residual disease in F-18 FDG PET as illustrated by this case.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Fibroma / radionuclide imaging. Fluorodeoxyglucose F18. Hodgkin Disease / diagnosis. Lymphoma / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Child. Diagnosis, Differential. False Positive Reactions. Female. Humans. Image Enhancement / methods. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / radionuclide imaging. Radiopharmaceuticals. Subtraction Technique

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  • (PMID = 17667441.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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37. Yalniz E, Alicioglu B, Yalcin O, Yilmaz B: Non specific magnetic resonance features of chondromyxoid fibroma of the iliac bone. J BUON; 2007 Jul-Sep;12(3):407-9
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  • [Title] Non specific magnetic resonance features of chondromyxoid fibroma of the iliac bone.
  • Chondromyxoid fibroma is a benign cartilaginous neoplasm.
  • The tumor is rare, perhaps the rarest of all bone tumors.
  • We report a case of a 31-year-old woman with chondromyxoid fibroma arising from the iliac bone and presenting with leg pain due to compression on the femoral nerve.
  • We emphasize the need to consider it in the differential diagnosis of chondrosarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondroma / diagnosis. Fibroma / diagnosis. Ilium. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • (PMID = 17918298.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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38. Valentini V, Nicolai G, Lorè B, Aboh IV: Intraosseous hemangiomas. J Craniofac Surg; 2008 Nov;19(6):1459-64
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  • Intraosseous hemangiomas are classified as benign tumors of vascular nature.
  • They originate and expand inside bone structures.
  • In 6 cases, the neoplasm localized in the zygomatic region; in 3 cases, at the mandible level; in 1 patient, in the maxillary site; and in 1 patient, in the frontal bone.
  • [MeSH-major] Hemangioma / diagnosis. Orbital Neoplasms / diagnosis. Skull Neoplasms / diagnosis. Zygoma / pathology
  • [MeSH-minor] Adult. Bone Transplantation / methods. Female. Follow-Up Studies. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Reconstructive Surgical Procedures / methods. Surgical Flaps. Temporal Muscle / transplantation. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19098533.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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39. Matsuo T, Hiyama E, Sugita T, Shimose S, Kubo T, Mochizuki Y, Adachi N, Kojima K, Sharman P, Ochi M: Telomerase activity in giant cell tumors of bone. Ann Surg Oncol; 2007 Oct;14(10):2896-902
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  • [Title] Telomerase activity in giant cell tumors of bone.
  • BACKGROUND: A giant cell tumor of bone (GCT) is a histologically benign neoplasma that has an unpredictable pattern of biological aggressiveness.
  • The telomere lengths of tumors were significantly shorter than those of normal tissue (P = .008).
  • The mean telomere length of grade 3 tumors was significantly shorter than those of grade 1 and 2 tumors (P = .038).
  • Telomerase activity was detected in 81% of tumor samples.
  • The level of telomerase activity in tumors with local recurrence was significantly higher than in tumors without local recurrence (P = .011).
  • [MeSH-major] Bone Neoplasms / genetics. Giant Cell Tumor of Bone / genetics. Telomerase / genetics
  • [MeSH-minor] Adolescent. Adult. Blotting, Southern. Bone and Bones / pathology. Bone and Bones / surgery. Extremities / surgery. Female. Femoral Neoplasms / genetics. Femoral Neoplasms / pathology. Femoral Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length / genetics. Prognosis

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  • (PMID = 17653593.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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40. Kumar A, Varshney MK, Trikha V, Rastogi S: An unusual presentation of a rare chest wall tumour: giant cell tumour of bone. Joint Bone Spine; 2007 Jan;74(1):100-2
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  • [Title] An unusual presentation of a rare chest wall tumour: giant cell tumour of bone.
  • Giant cell tumour of bone is an aggressive benign bone tumour.
  • We report a case of giant cell tumour of the anterior end of the rib masquerading as a sub-mammary abscess in lactating women.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Thoracic Wall
  • [MeSH-minor] Abscess / diagnosis. Adult. Diagnosis, Differential. Female. Humans. Lactation. Treatment Outcome

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  • (PMID = 17197221.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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41. Studart-Soares EC, Costa FW, Sousa FB, Alves AP, Osterne RL: Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e691-6
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  • OBJECTIVES: Lipomas are common benign mesenchymal neoplasms that rarely occur in the oral cavity and correspond to less than 4.4% of all benign oral soft tissue tumors.
  • Age, gender, tumor location, clinical findings, duration, histological subtypes, and treatment outcome were recorded.
  • The mean size of the tumors was 1.94 cm (range 1.0 to 3.0 cm).
  • The duration of the tumors ranged from 2 to 84 months, with a mean duration of 30.4 months.
  • CONCLUSIONS: Lipomas continue to be an uncommon neoplasm of the oral cavity.
  • Radiography is a valuable tool due to the possible occurrence of bone involvement.
  • [MeSH-major] Lipoma / diagnosis. Mouth Neoplasms / diagnosis

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  • (PMID = 20383107.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
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42. Malek F, Krueger P, Hatmi ZN, Malayeri AA, Faezipour H, O'Donnell RJ: Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy. Int Orthop; 2006 Dec;30(6):495-8
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  • [Title] Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy.
  • Giant cell tumour (GCT) is a benign, but aggressive, primary tumour of the bone.
  • Many surgical techniques have been employed in the treatment of this tumour.
  • In addition to curettage, various adjuvant procedures and packing materials have been advocated in order to control and reconstruct long bone defects secondary to this neoplasm.
  • We report our experience with 40 long bone GCT patients treated with curettage, burring, bone grafting and no adjuvants between 1997 and 2002.
  • The risk of local recurrence in this study is acceptable (within the range that has been historically reported for curettage and bone grafting).
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cohort Studies. Developing Countries. Female. Humans. Iran. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Retrospective Studies

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  • (PMID = 16896875.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3172751
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43. Ogütcen-Toller M, Sener I, Kasap V, Cakir-Ozkan N: Maxillary myxoma: surgical treatment and reconstruction with buccal fat pad flap: a case report. J Contemp Dent Pract; 2006 Feb 15;7(1):107-16
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  • Myxoma is a benign tumor that arises from mesenchymal tissue and is found less commonly in the bone than in soft tissue.
  • When compared with other odontogenic tumors, myxoma of the jaws is a rare entity.
  • Numerous types of treatment have been used for these tumors including simple curettage, enucleation, curettage with peripheral ostectomy, and en bloc resection with or without immediate reconstruction.
  • [MeSH-minor] Adult. Bone Substitutes. Bone Transplantation. Cheek. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Oroantral Fistula / surgery. Reconstructive Surgical Procedures. Surgical Flaps. Tomography, X-Ray Computed

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  • (PMID = 16491153.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / OsteoGraf-N
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44. Chen YR, Chang CN, Tan YC: Craniofacial fibrous dysplasia: an update. Chang Gung Med J; 2006 Nov-Dec;29(6):543-9
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  • Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue.
  • It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton.

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  • (PMID = 17302216.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 50
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45. Liu H, Sun J, Wang Y, Yang X, Zhu E: [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Nov;22(11):1349-53
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  • [Title] [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow].
  • OBJECTIVE: To investigate the clinical application of grafting with bioactive glass (BG) and autologous bone marrow for defect after resection and curettage of benign bone neoplasm.
  • METHODS: From January 2004 to May 2007, 34 patients with bone defects were repaired.
  • There were 14 cases of simple bone cysts, 6 cases of fibrous dysplasia, 3 cases of osteoid osteoma, 4 cases of non-ossifying fibroma, 2 cases of enchondroma and 3 cases of giant cell tumor of bone.
  • Tumor sizes varied from 2.0 cm x 1.5 cm x 1.0 cm to 9.0 cm x 3.0 cm x 2.5 cm.
  • Benign bone neoplasm was removed thoroughly with a curet or osteotome, bone defects ranged from 3.0 cm x 2.0 cm x 1.5 cm to 11.0 cm x 3.5 cm x 3.0 cm, which was closed-up with the mixtures of BG and autogenous red bone marrow.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone healing.
  • At averaged 16 weeks after operation, patients with bone tumor in lower limbs resumed walking independently and those with bone tumor in upper limbs resumed holding object.
  • There was no tumor recurrence during follow-up.
  • Radiographically, the interface between the implanted bone and host bone became fuzzy 1 month after implantation.
  • Two months after operation, the BG was absorbed gradually, new bone formation could be seen in the defects.
  • Four months after operation, implanted bone and host bone merged together, bone density increased.
  • Six to ten months after operation, the majority of the implanted BG was absorbed and substituted for new bone, bone remodeling was established.
  • CONCLUSION: BG may boast both bone conductive and bone inductive activities.
  • The combined grafting with BG and autologous bone marrow appears to be minimally invasive treatment to repair bone defects of benign bone neoplasm, with rare complications and no significant reverse reaction, and could repair bone defects completely.
  • [MeSH-major] Bone Marrow Transplantation. Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Bone and Bones / pathology. Child. Female. Follow-Up Studies. Glass. Humans. Male. Middle Aged. Transplantation, Autologous

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  • (PMID = 19068605.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes
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46. Prado MP, Mendes AA, Amodio DT: Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports. Einstein (Sao Paulo); 2010 Sep;8(3):354-7
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  • [Title] Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports.
  • Two cases of benign chondral tumors of the talar neck region (an osteoid osteoma and a chondroblastoma) were described.

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  • (PMID = 26760154.001).
  • [ISSN] 1679-4508
  • [Journal-full-title] Einstein (São Paulo, Brazil)
  • [ISO-abbreviation] Einstein (Sao Paulo)
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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47. Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M: Osteochondromas: review of the clinical, radiological and pathological features. In Vivo; 2008 Sep-Oct;22(5):633-46
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  • Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones.
  • This tumor takes the form of a cartilage-capped bony outgrowth on the surface of the bone.
  • Approximately 15% of osteochondromas occur as multiple lesions in the context of hereditary multiple osteochondromas (HMOs), a disorder that is inherited in an autosomal dominant manner.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Osteochondroma / pathology. Osteochondroma / radiography

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  • (PMID = 18853760.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 125
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48. Zustin J, Akpalo H, Gambarotti M, Priemel M, Rueger JM, Luebke AM, Reske D, Lange C, Pueschel K, Lohmann C, Rüther W, Amling M, Alberghini M: Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study. Am J Pathol; 2010 Sep;177(3):1072-8
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  • [Title] Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study.
  • Chondromyxoid fibroma represents a rare benign cartilaginous tumor of young patients occurring in a subcortical metaphyseal location.
  • Based on the observed substantial morphological similarity between the cartilage canals and chondromyxoid fibroma, we suggest that the chondromyxoid fibroma represents a neoplasm originating from or mimicking the fetal cartilage canals within the immature cartilage.

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  • (PMID = 20671262.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. O'Malley DP, Kim YS, Perkins SL, Baldridge L, Juliar BE, Orazi A: Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders. Mod Pathol; 2005 Dec;18(12):1550-61
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  • [Title] Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders.
  • Extramedullary hematopoiesis seen in non-neoplastic conditions can occasionally be extensive and raise concerns for a myeloid neoplasm.
  • Post-bone marrow transplant and thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome spleens showed extramedullary hematopoiesis with some morphologic features of immaturity, which could simulate chronic myeloproliferative disorder.
  • [MeSH-major] Bone Marrow / pathology. Bone Marrow Neoplasms / pathology. Hematopoiesis, Extramedullary. Myeloproliferative Disorders / pathology. Spleen / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Proliferation. Child. Child, Preschool. Humans. Middle Aged

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  • (PMID = 16118626.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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50. Tanigawa N, Kariya S, Kojima H, Komemushi A, Fujii H, Sawada S: Lower limb ischaemia caused by fractured osteochondroma of the femur. Br J Radiol; 2007 Apr;80(952):e78-80
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  • Osteochondroma is the most common benign bone tumour and can arise in any bone.
  • [MeSH-major] Bone Neoplasms / complications. Exostoses, Multiple Hereditary / complications. Femoral Fractures / complications. Ischemia / etiology. Leg / blood supply


51. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • The peak incidence of this neoplasm is in the first two decades of life.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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52. Sim IW, Tse LF, Ek ET, Powell GJ, Choong PF: Salvaging the limb salvage: management of complications following endoprosthetic reconstruction for tumours around the knee. Eur J Surg Oncol; 2007 Aug;33(6):796-802
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  • [Title] Salvaging the limb salvage: management of complications following endoprosthetic reconstruction for tumours around the knee.
  • INTRODUCTION: Limb-salvage surgery, including endoprosthetic reconstruction after tumour resection, has become the standard management for local control of tumours around the knee.
  • METHODS: Retrospective analysis of consecutive resections and endoprosthetic reconstructions for tumours around the knee between 1996 and September 2005 performed at St Vincent's Hospital, Melbourne.
  • Tumour types included 38 primary musculoskeletal malignancies, 8 metastatic tumours, 2 bony lymphomas and 2 benign lesions.
  • CONCLUSION: Resection and endoprosthetic reconstruction of tumours around the knee is both technically challenging and resource-intensive.
  • [MeSH-minor] Adolescent. Adult. Aged. Amputation. Bone Neoplasms / surgery. Female. Follow-Up Studies. Humans. Intraoperative Complications. Joint Prosthesis. Male. Middle Aged. Muscle Neoplasms / surgery. Neoplasm Metastasis. Popliteal Artery / injuries. Postoperative Complications. Prosthesis Failure. Reoperation. Retrospective Studies. Surgical Wound Infection / etiology. Survival Rate. Treatment Outcome

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  • (PMID = 17291709.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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53. Röpke M, Boltze C, Meyer B, Neumann HW, Roessner A, Schneider-Stock R: Rb-loss is associated with high malignancy in chondrosarcoma. Oncol Rep; 2006 Jan;15(1):89-95
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  • We studied the loss of heterozygosity (LOH) of the Rb gene in 31 formalin-fixed, paraffin-embedded cartilaginous tumors using polymerase chain reaction.
  • The tumors were subdivided into 8 cases of dedifferentiated (DD) chondrosarcoma, 17 cases of conventional chondrosarcoma (nine grade 1, seven grade 2 and one grade 3), 4 enchondromas and 2 chondroblastomas.
  • All tumors with Rb-LOH were immunohistochemically Rb-negative.
  • The only case of DD chondrosarcoma negative for Rb-LOH in both components of the tumor also showed weak expression of the Rb protein in the anaplastic component.
  • All benign cartilaginous tumors, low-grade chondrosarcomas and low-grade tumor components of DD chondrosarcomas were negative regarding Rb-LOH but positive in Rb immunohistostaining.
  • However, it is not a marker for identifying low-grade tumors with a tendency towards progression or local recurrence.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Genes, Retinoblastoma / genetics. Loss of Heterozygosity / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. DNA, Neoplasm / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retinoblastoma Protein / analysis. Retinoblastoma Protein / genetics


54. Abula A, Abaiyedula A, Yusufu A, Liu C, Huang H: [Preliminary clinical application of cancellous granule-type calcium phosphate cement]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Sep;24(9):1100-2
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  • OBJECTIVE: To investigate the clinical efficacy of the cancellous granule-type calcium phosphate cement in repair bone defect.
  • METHODS: Between July 2008 and July 2009, 35 patients (42 limbs) with fractures, nonunion, and benign bone tumor were treated with cancellous granule-type calcium phosphate cement.
  • There were 32 males and 3 females, with an age range from 9 to 73 years (median, 41 years), including 24 limb fractures (19 cases), 4 osteotomy for deformity of ulna and radius (2 cases), 2 femur intertrochanteric bony cysts (2 cases), 3 enchondroma (3 cases), 5 bone defect at donor ilium (5 cases), 3 nonunion (3 cases), and 1 lumbar spinal stenosis (1 case).
  • The size of bone defect was 1-5 cm.
  • Bone defect was repaired with cancellous granule-type calcium phosphate cement (1-5 g).
  • Incision dehiscence occurred in 2 cases, and wounds healed after second debridement and removal of artificial bone.
  • X-ray films showed that bone graft fusion was achieved and bone defect was radically repaired at 6 months after operation and artificial bone was absorbed completely at 12 months.
  • CONCLUSION: Cancellous granule-type calcium phosphate cement can be used as a new graft bone material, which is suitable for defect filling after traumatic fracture, benign bone tumors, and iliac bone donor.
  • [MeSH-major] Bone Cements. Bone Transplantation / instrumentation. Calcium Phosphates / therapeutic use

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  • (PMID = 20939483.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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56. Jonathan A, Rajshekhar V, Chacko G: Chondromyxoid fibroma of the seventh cervical vertebra. Neurol India; 2008 Jan-Mar;56(1):84-7
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  • Chondromyxoid fibroma is a rare benign bone tumor representing less than 0.5% of all bone tumors.
  • A presumptive diagnosis of a bony tumor such as an aneurysmal bone cyst or a giant cell tumor involving the seventh vertebral body was made on plain X-rays, MRI and bone scan.
  • He underwent C7 central corpectomy, incomplete intralesional curettage with iliac bone grafting and C6 to T1 interspinous wiring.
  • The histological diagnosis was chondromyxoid fibroma.
  • On eight years' follow-up, CT scan showed no progression of the tumor with good alignment and fusion of the graft at the site of the corpectomy.
  • The authors conclude that corpectomy and iliac bone grafting for chondromyxoid fibroma has a good outcome on long-term follow-up.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / pathology. Cervical Vertebrae / pathology. Chondromatosis / complications. Fibroma / complications. Fibroma / pathology

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  • (PMID = 18310848.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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57. Abdalla RJ, Cohen M, Nóbrega J, Forgas A: SYNOVIAL GIANT CELL TUMOR OF THE KNEE. Rev Bras Ortop; 2009 Jan;44(5):437-40
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  • [Title] SYNOVIAL GIANT CELL TUMOR OF THE KNEE.
  • Synovial giant cell tumor is a benign neoplasm, rarely reported in the form of malignant metastasis.
  • Synovial giant cell tumor most frequently occurs on the hand, and, most uncommon, on the ankle and knee.
  • In the present study, the authors describe a rare case of synovial giant cell tumor on the knee as well as the treatment approach.
  • Arthroscopy has been shown, in this case, to be the optimal method for treating this kind of lesion, once it allowed a less aggressive approach, while providing good visualization of all compartments of knee joint and full tumor resection.

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  • (PMID = 27004193.001).
  • [ISSN] 2255-4971
  • [Journal-full-title] Revista brasileira de ortopedia
  • [ISO-abbreviation] Rev Bras Ortop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC4783680
  • [Keywords] NOTNLM ; Giant cell tumor / Knee / Neoplasm / Synovial
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58. Mukonoweshuro P, Oriowolo A: Stromal osseous metaplasia in a low-grade ovarian adenocarcinoma. Gynecol Oncol; 2005 Oct;99(1):222-4
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  • [Title] Stromal osseous metaplasia in a low-grade ovarian adenocarcinoma.
  • BACKGROUND: Stromal osseous metaplasia is a rare and curious finding in tumors of the ovary.
  • The tumor recurred 21 years later with prominent stromal osseous metaplasia that had not been present in the primary.
  • DISCUSSION: The pathogenesis of osseous metaplasia in epithelial tumors of the ovary is unclear; however, it is probable that a metaplastic process involving multipotential stromal stem cells results in bone formation.
  • CONCLUSION: Benign osseous metaplasia in ovarian tumors is rare and its histogenesis remains unclear.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Neoplasm Recurrence, Local / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 16023183.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Freeman SJ, Sonoda LI, Seshadri N, Howard W, Set PA, Balan KK: What is the significance of solitary bony abnormalities on bone scintigrams of children with malignancy? Pediatr Hematol Oncol; 2010 Aug;27(5):380-6
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  • [Title] What is the significance of solitary bony abnormalities on bone scintigrams of children with malignancy?
  • This investigation was undertaken to evaluate the significance of solitary bony abnormalities on bone scintigrams of children with known or suspected malignancy.
  • A total of 215 bone scans were performed in 183 children in order to look for possible metastasis over a 10-year period.
  • Of the remaining 31 lesions, 13 (41.9%) were confirmed as metastases, 17 lesions were proved to be benign, and 1 indeterminate.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone and Bones / radionuclide imaging. Neoplasm Metastasis / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Infant, Newborn. Radionuclide Imaging / methods. Radiopharmaceuticals. Retrospective Studies. Technetium Tc 99m Medronate

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  • (PMID = 20469974.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; X89XV46R07 / Technetium Tc 99m Medronate
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60. Fukunaga S, Futani H, Yoshiya S: Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome. World J Surg Oncol; 2007;5:37
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  • BACKGROUND: Osteochondroma is the most common benign bone tumor in the scapula.
  • Removal of the tumor was performed by the use of endoscopically assisted resection.
  • The tumor was resected in a piece-by-piece manner by the use of graspers through the same portal.
  • CT images showed complete tumor resection.
  • [MeSH-major] Bone Neoplasms / surgery. Endoscopy. Osteochondroma / surgery. Scapula

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  • [Cites] Arch Phys Med Rehabil. 1997 May;78(5):506-11 [9161370.001]
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  • (PMID = 17378939.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1839090
  • [General-notes] NLM/ Original DateCompleted: 20070726
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61. Bostan B, Sen C, Gunes T, Erdem M, Koseoglu RD: Osteoid osteoma of the trapezium: case report. J Hand Surg Am; 2010 Apr;35(4):636-8
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  • Osteoid osteoma is a benign bone tumor representing approximately 10% of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Trapezium Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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  • (PMID = 20171814.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Eckardt AM, Kokemüller H, Flemming P, Schultze A: Recurrent ameloblastoma following osseous reconstruction--a review of twenty years. J Craniomaxillofac Surg; 2009 Jan;37(1):36-41
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  • [Title] Recurrent ameloblastoma following osseous reconstruction--a review of twenty years.
  • BACKGROUND: The adequate therapy of ameloblastoma may require a compromise between the least destructive treatment possible of a benign tumour and a sufficiently radical method to prevent recurrences.
  • The primary reconstruction of bones and/or soft tissues, which is likely to be performed especially for benign processes is threatened by recurrences.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Reconstructive Surgical Procedures
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bone Transplantation. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Mandibular Neoplasms / pathology. Mandibular Neoplasms / surgery. Maxillary Neoplasms / pathology. Maxillary Neoplasms / surgery. Middle Aged. Retrospective Studies. Surgical Flaps. Young Adult

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  • (PMID = 19022680.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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63. Singh R, Jain M, Siwach R, Rohilla RK, Kaur K: Unusual presentation of bizarre parosteal osteochondromatous lesion of the second toe (Nora's lesion). Foot Ankle Spec; 2010 Dec;3(6):347-51
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  • Bizarre parosteal osteochondromatous proliferation (BPOP) of bone is a rare benign neoplasm.
  • Although local excision of the tumor is the treatment of choice, the authors resorted to ray excision, as gangrenous changes and ulceration were present and there was the possibility of malignant change.
  • [MeSH-major] Bone Neoplasms / pathology. Foot Ulcer / pathology. Osteochondroma / pathology. Periosteum / pathology. Toes / pathology

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  • (PMID = 20624925.001).
  • [ISSN] 1938-7636
  • [Journal-full-title] Foot & ankle specialist
  • [ISO-abbreviation] Foot Ankle Spec
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Jundt G, Baumhoer D: [Hereditary bone tumors]. Pathologe; 2010 Oct;31(6):471-6
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  • [Title] [Hereditary bone tumors].
  • Familial diseases leading to bone tumor formation are rare.
  • This leads to multiple benign bone tumors, which may undergo secondary malignant transformation (enchondromatosis: enchondromas, multiple hereditary exostoses: osteochondromas) or bone sarcomas, mainly osteosarcomas, such as primary (Li-Fraumeni, Rothmund-Thomson, Werner and Bloom syndromes) or secondary manifestations (retinoblastoma syndrome) of the underlying disease.
  • In contrast to sporadically occurring similar tumors, differences in manifestation in time, topography or histology may be present which can aid in the correct recognition of the underlying syndrome.
  • [MeSH-major] Bone Neoplasms / genetics

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  • (PMID = 20960198.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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65. Dierselhuis EF, Jutte PC, van der Eerden PJ, Suurmeijer AJ, Bulstra SK: Hip fracture after radiofrequency ablation therapy for bone tumors: two case reports. Skeletal Radiol; 2010 Nov;39(11):1139-43
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  • [Title] Hip fracture after radiofrequency ablation therapy for bone tumors: two case reports.
  • In orthopedic surgery, RFA is used for the treatment of benign bone tumors and bone metastases.
  • Complications are rare and, to our knowledge, bone fracture as a complication due solely to RFA has not been reported to date.
  • In this report we describe two patients with a fracture in the calcar region of the femur as a complication of RFA treatment for bone malignancies.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Catheter Ablation / adverse effects. Femoral Fractures / diagnosis. Femoral Fractures / etiology. Magnetic Resonance Imaging. Tomography, X-Ray Computed


66. Li J, Wang ZQ, Zhang YM, Song HP, Yuan L: [Application of allogeneic bone in surgical treatment of benign bone neoplasm]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jul;26(7):987-90
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  • [Title] [Application of allogeneic bone in surgical treatment of benign bone neoplasm].
  • OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone.
  • METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft.
  • RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation.
  • The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery.
  • CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods

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  • (PMID = 16864094.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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67. Henry CJ, Brewer WG Jr, Whitley EM, Tyler JW, Ogilvie GK, Norris A, Fox LE, Morrison WB, Hammer A, Vail DM, Berg J, Veterinary Cooperative Oncology Group (VCOG): Canine digital tumors: a veterinary cooperative oncology group retrospective study of 64 dogs. J Vet Intern Med; 2005 Sep-Oct;19(5):720-4
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  • [Title] Canine digital tumors: a veterinary cooperative oncology group retrospective study of 64 dogs.
  • We compared clinical characteristics and outcomes for dogs with various digital tumors.
  • Risk factors examined included age, weight, sex, tumor site (hindlimb or forelimb), local tumor (T) stage, metastases, tumor type, and treatment modality.
  • Squamous cell carcinoma (SCC) accounted for 33 (51.6%) of the tumors.
  • Other diagnoses included malignant melanoma (MM) (n = 10; 15.6%), osteosarcoma (OSA) (n = 4; 6.3%), hemangiopericytoma (n = 3; 4.7%), benign soft tissue tumors (n = 5; 7.8%), and malignant soft tissue tumors (n = 9; 14%).
  • None of the patient variables assessed, including age, sex, tumor type, site, and stage, had a significant impact on ST.
  • Although metastasis at diagnosis correlated with a shorter LDFI, it did not have a significant impact on ST.
  • On the basis of these findings, early surgical intervention is advised for the treatment of dogs with digital tumors, regardless of tumor type or the presence of metastatic disease.


68. Schmidt GP, Schoenberg SO, Reiser MF, Baur-Melnyk A: Whole-body MR imaging of bone marrow. Eur J Radiol; 2005 Jul;55(1):33-40
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  • [Title] Whole-body MR imaging of bone marrow.
  • In clinical routine, multimodality algorithms, including X-ray, computed tomography, scintigraphy and MRI, are used in case of suspected bone marrow malignancy.
  • Skeletal scintigraphy is widely used to asses metastatic disease to the bone, CT is the technique of choice to assess criteria of osseous destruction and bone stability.
  • MRI is the only imaging technique that allows direct visualization of bone marrow and its components with high spatial resolution.
  • The combination of unenhanced T1-weighted-spin echo- and turbo-STIR-sequences have shown to be most useful for the detection of bone marrow abnormalities and are able to discriminate benign from malignant bone marrow changes.
  • Originally, whole-body MRI bone marrow screening was performed in sequential scanning techniques of five body levels with time consuming coil rearrangement and repositioning of the patient.
  • Whole-body MRI represents a new alternative to the stepwise multimodality concept for the detection of metastatic disease, multiple myeloma and lymphoma of the bone with high diagnostic accuracy.
  • [MeSH-major] Bone Marrow Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Diagnosis, Differential. Humans. Neoplasm Metastasis / diagnosis. Sensitivity and Specificity

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  • (PMID = 15950099.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 40
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69. Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA: Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J; 2006;26:69-76
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  • [Title] Ethanol as a local adjuvant for giant cell tumor of bone.
  • Giant cell tumor is an aggressive benign neoplasm of bone.
  • No report on its use in a group of patients with giant cell tumor is available.
  • Records were retrospectively reviewed for all giant cell tumors treated by intralesional curettage and high concentration ethanol irrigation as the only chemical adjuvant.
  • Twenty-five primary excisional curettages and 12 repeat curettages for giant cell tumors of bone were performed in 31 patients.
  • [MeSH-major] Bone Neoplasms / therapy. Ethanol / therapeutic use. Giant Cell Tumor of Bone / therapy

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  • (PMID = 16789453.001).
  • [ISSN] 1541-5457
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
  • [Other-IDs] NLM/ PMC1888590
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70. Abdel MP, Papagelopoulos PJ, Morrey ME, Wenger DE, Rose PS, Sim FH: Surgical management of 121 benign proximal fibula tumors. Clin Orthop Relat Res; 2010 Nov;468(11):3056-62
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  • [Title] Surgical management of 121 benign proximal fibula tumors.
  • BACKGROUND: Tumors of the fibula comprise only 2.5% of primary bone lesions.
  • Patients with aggressive benign tumors in the proximal fibula may require en bloc resection.
  • QUESTIONS/PURPOSES: We therefore analyzed the incidence of peroneal nerve palsy, knee stability, and local recurrence following surgical treatment of benign proximal fibula tumors.
  • METHODS: We retrospectively reviewed the charts of 120 patients (121 tumors) with histologically confirmed aggressive benign tumors of the proximal fibula.
  • The most common diagnosis was osteochondroma (38%) followed by giant cell tumor (19%).
  • Of the 121 tumors, 56 (46%) underwent en bloc resection.
  • CONCLUSIONS: Given the higher recurrence rate with curettage, patients with aggressive proximal fibula tumors benefit from en bloc resection.
  • [MeSH-major] Bone Neoplasms / surgery. Fibula / surgery. Orthopedic Procedures / adverse effects
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Curettage / adverse effects. Female. Humans. Joint Instability / etiology. Joint Instability / physiopathology. Knee Joint / physiopathology. Male. Middle Aged. Neoplasm Recurrence, Local. Osteotomy / adverse effects. Peroneal Neuropathies / etiology. Range of Motion, Articular. Retrospective Studies. Surgical Wound Dehiscence / etiology. Time Factors. Treatment Outcome. Venous Thrombosis / etiology. Young Adult

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  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Korshunov A, Cherekaev V, Bekyashev A, Sycheva R: Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region. J Neurooncol; 2007 Jan;81(2):131-7
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  • [Title] Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region.
  • Mean number of aberrations detected per tumor was significantly greater for invasive meningiomas-67.4 compared with 40.5 for non-invasive MSR.
  • Thus, the presence of a complex cytogenetic profile and progression-associated chromosomal aberrations in benign MSR is associated with their increased invasive potential.
  • [MeSH-major] Chromosome Aberrations. Meningeal Neoplasms / genetics. Meningioma / genetics. Neoplasm Recurrence, Local / genetics. Sphenoid Bone / pathology

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  • (PMID = 16850103.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
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72. Micheli A, Trapani S, Brizzi I, Campanacci D, Resti M, de Martino M: Myositis ossificans circumscripta: a paediatric case and review of the literature. Eur J Pediatr; 2009 May;168(5):523-9
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  • Myositis ossificans circumscripta (MOC), characterised by non-neoplastic heterotopic bone formation in soft tissue and skeletal muscle, is rare in children.
  • At onset, it is difficult to distinguish MOC from a musculoskeletal infection or neoplasm, particularly in absence of trauma, and a biopsy is frequently required.
  • Three months after diagnosis, surgical excision was performed.
  • Our case study confirms the good prognosis of MOC and underlines how this benign condition should be considered in children presenting a tender and painful soft-tissue swelling.
  • [MeSH-major] Bone and Bones. Musculoskeletal Diseases. Myositis Ossificans / diagnosis. Myositis Ossificans / physiopathology
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents / therapeutic use. Biopsy. Child. Diagnosis, Differential. Humans. Lymphadenitis / diagnosis. Magnetic Resonance Imaging. Male. Muscle, Skeletal / metabolism. Muscle, Skeletal / pathology. Necrosis / pathology. Osteoblasts / metabolism. Sarcoma / pathology. Soft Tissue Injuries / diagnosis. Soft Tissue Injuries / metabolism. Soft Tissue Injuries / pathology

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  • (PMID = 19130083.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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  • [Number-of-references] 35
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73. Murphey MD: World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists. Semin Musculoskelet Radiol; 2007 Sep;11(3):201-14
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  • [Title] World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists.
  • The working group of the World Health Organization (WHO) for classification of tumors of soft tissue and bone met in 2002.
  • The consensus of this conference led to modifications in the nomenclature primarily for soft tissue neoplasm, leaving osseous tumors largely unaltered.
  • This allows improved uniformity in our discussions with pathologists and orthopedic oncologists in our team approach in the diagnosis and treatment of these patients.
  • [MeSH-major] Bone Neoplasms / classification. Diagnostic Imaging. Soft Tissue Neoplasms / classification. World Health Organization
  • [MeSH-minor] Fibrosarcoma / classification. Histiocytoma, Benign Fibrous / classification. Humans. Liposarcoma / classification. Terminology as Topic


74. Yadia S, Randazzo CG, Malik S, Gressen E, Chasky M, Kenyon LC, Ratliff JK: Pilomatrix carcinoma of the thoracic spine: case report and review of the literature. J Spinal Cord Med; 2010;33(3):272-7
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  • CONTEXT: Pilomatrixoma is a common head and neck neoplasm in children.
  • The patient underwent resection of the axillary mass and spinal reconstruction of the fracture; the pathology was consistent with synchronous benign pilomatrixomas.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma / secondary. Hair Diseases. Pilomatrixoma / pathology. Skin Neoplasms / pathology. Spine / pathology

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  • (PMID = 20737803.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2920123
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75. Fisher CG, Keynan O, Boyd MC, Dvorak MF: The surgical management of primary tumorsof the spine: initial results of an ongoing prospective cohort study. Spine (Phila Pa 1976); 2005 Aug 15;30(16):1899-908
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  • OBJECTIVES: To prospectively validate the application of appendicular surgical oncology principles to the treatment of primary bone tumors of the spine at a quaternary care spine center using local recurrence, survival, and health-related quality of life as outcome measures.
  • Previous publications have retrospectively demonstrated this oncologically sound approach to spine tumor management to be internally valid.
  • METHODS: Included were all patients who underwent en bloc surgical resection of a primary tumor of the spine between January 1994 and November 2003, at the authors' institution.
  • There were 19 malignant tumors and 7 benign.
  • There are 20 surviving patients with an average follow-up of 41.5 months (range 6 to 111 months), 15 of whom had malignant tumors.
  • CONCLUSIONS: Principles of wide surgical resection, commonly applied in appendicular oncology, can and should be used for the treatment of primary bone tumors of the spine with anticipated acceptable morbidity and satisfactory survival.
  • [MeSH-minor] Adolescent. Adult. Aged. Cohort Studies. Female. Health Status. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prospective Studies. Quality of Life. Survival Analysis

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  • (PMID = 16103863.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] United States
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76. Angiero F, Mellone P, Baldi A, Stefani M: Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo; 2006 Sep-Oct;20(5):665-70
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  • Osteoblastoma is a benign bone tumor of osteoblastic origin.
  • Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy.
  • Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed.
  • [MeSH-major] Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 17091775.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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77. Taylor JA 3rd, Ristau B, Bonnemaison M, Voznesensky OS, Hegde P, Kuchel GA, Pilbeam CC: Regulation of the prostaglandin pathway during development of invasive bladder cancer in mice. Prostaglandins Other Lipid Mediat; 2009 Jan;88(1-2):36-41
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  • Prostaglandin E(2) (PGE(2)) is reported to play an important role in tumor development.
  • Hence, increased COX-2 and decreased PDGH expression occurred throughout tumor development, while mPGES-1, EP2R and EP4R were elevated only before development of invasive cancer.
  • We compared expression of these genes in the malignant human urothelial cell lines, HTB-5 and HT-1376, with expression in a benign urothelial cell line, UROtsa.
  • Neither malignant cell line reproduced the complete in vivo pattern, relative to benign cells, but each showed abnormal basal expression of several of the genes downstream of COX-2, but not COX-2 itself.
  • We conclude that components involved in PGE(2) synthesis and activity are differentially regulated during bladder tumor development and the therapeutic efficacy of targeting the various components may vary with stage of tumor development.

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  • (PMID = 18834948.001).
  • [ISSN] 1098-8823
  • [Journal-full-title] Prostaglandins & other lipid mediators
  • [ISO-abbreviation] Prostaglandins Other Lipid Mediat.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK048361; United States / NIDDK NIH HHS / DK / DK048361-08; United States / NIA NIH HHS / AG / R01AG028657; United States / NIDDK NIH HHS / DK / R01 DK048361-08; United States / NIA NIH HHS / AG / AG028657-02; United States / NIDDK NIH HHS / DK / DK048361-13; United States / NIA NIH HHS / AG / R01 AG028657; United States / NIA NIH HHS / AG / R01 AG028657-02; United States / NIDDK NIH HHS / DK / R01DK48361; United States / NIDDK NIH HHS / DK / R01 DK048361-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Prostaglandins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS84408; NLM/ PMC2615552
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78. Cabrera RA, Almeida M, Mendonça ME, Frable WJ: Diagnostic pitfalls in fine-needle aspiration cytology of temporomandibular chondroblastoma: report of two cases. Diagn Cytopathol; 2006 Jun;34(6):424-9
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  • Chondroblastoma is a benign bone neoplasm, which usually presents in the epiphysis of long bones, but can occur in unusual locations.
  • This emphasizes the diagnostic pitfalls of this entity and expands the cytologic differential diagnosis of tumors of the parotid region.
  • [MeSH-major] Biopsy, Fine-Needle. Bone Neoplasms / diagnosis. Chondroblastoma / diagnosis. Mandible / pathology. Temporal Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Parotid Neoplasms / pathology. Synovitis, Pigmented Villonodular / pathology

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  • (PMID = 16680777.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Theumann N, Hauser P, Schmidt S, Schnyder P, Leyvraz PF, Mouhsine E: [Osteoid osteoma and radiofrequency]. Rev Med Suisse; 2005 Dec 21;1(46):2989-94
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  • [Transliterated title] Thermoablation par radiofréquence de l'ostéome ostéoïde.
  • Osteoid osteoma and radiofrequency Osteoid osteoma relates to a benign skeletal neoplasm, smaller than 2 cm in diameter, composed of osteoid, highly vascularized connective tissue and surrounded by a ring of bone sclerosis.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Osteoma, Osteoid / surgery

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  • (PMID = 16429972.001).
  • [ISSN] 1660-9379
  • [Journal-full-title] Revue médicale suisse
  • [ISO-abbreviation] Rev Med Suisse
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Salicylates
  • [Number-of-references] 12
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80. Gasbarrini A, Cappuccio M, Donthineni R, Bandiera S, Boriani S: Management of benign tumors of the mobile spine. Orthop Clin North Am; 2009 Jan;40(1):9-19, v
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  • [Title] Management of benign tumors of the mobile spine.
  • In the treatment of primary tumors, complete local eradication is the main goal, as an oncologically appropriate surgical treatment can substantially improve the prognosis and even be considered a life-saving procedure.
  • In deciding the best treatment for primary bone tumors of the spine, the choice of surgery, radiation therapy, chemotherapy, selective arterial embolization, or other medical treatments alone or in combination is based on diagnosis, staging, and a deep understanding of the biology and the behavior of each tumor.
  • This article is a guide to diagnosing and treating such rare tumors.
  • [MeSH-major] Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery
  • [MeSH-minor] Humans. Neoplasm Staging. Spinal Diseases / diagnosis. Spinal Diseases / surgery

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  • (PMID = 19064052.001).
  • [ISSN] 0030-5898
  • [Journal-full-title] The Orthopedic clinics of North America
  • [ISO-abbreviation] Orthop. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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81. Kelly RJ, Barrett C, Swan N, McDermott R: Metastatic phyllodes tumor causing small-bowel obstruction. Clin Breast Cancer; 2009 Aug;9(3):193-5
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  • [Title] Metastatic phyllodes tumor causing small-bowel obstruction.
  • Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas.
  • These usually metastasize to the lung, pleura, bone, and liver.
  • This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction.
  • Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems.
  • The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Ileal Neoplasms / secondary. Intestinal Obstruction / etiology. Phyllodes Tumor / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19661046.001).
  • [ISSN] 1938-0666
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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82. Poffyn B, Sys G, Van Maele G, Van Hoorebeke L, Forsyth R, Verstraete K, Uyttendaele D: Radiographic analysis of extracorporeally irradiated autografts. Skeletal Radiol; 2010 Oct;39(10):999-1008
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  • OBJECTIVE: To analyse the long-term radiographic findings of intercalary, pure osteoarticular, and composite bone grafts in patients with primary bone sarcoma who were treated by reimplantation of the bone as an orthotopic autograft.
  • MATERIALS AND METHODS: For this observational clinical study, 107 patients who presented with 108 malignant or locally aggressive benign bone tumours were treated by resection, extracorporeal irradiation (300 Gy), and reimplantation and fixation of the autograft.
  • Bone healing features were evaluated with the International Society of Limb Salvage (ISOLS) graft evaluation method, which assesses fusion, resorption, fracture, graft shortening, fixation, subluxation, joint narrowing, and subchondral bone.
  • CONCLUSION: This reconstruction technique is valid for the three methods described; bone stock is retained and, once the graft has healed, it behaves as normal bone.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / diagnostic imaging. Bone Transplantation / methods. Sarcoma / surgery

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  • (PMID = 20703876.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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83. Narita T, Ishii N, Mayuzumi H, Kobayashi H, Ikeda J, Iwasaki Y: Occipitoparietal benign osteoblastoma: should entire lesion be resected when magnetic resonance images reveal wide abnormal signal intensity in surrounding bone marrow? Surg Neurol; 2005 Aug;64(2):180-3; discussion 184
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  • [Title] Occipitoparietal benign osteoblastoma: should entire lesion be resected when magnetic resonance images reveal wide abnormal signal intensity in surrounding bone marrow?
  • BACKGROUND: Benign osteoblastoma is an uncommon primary bone tumor that usually affects long bones and the vertebral column.
  • Despite the characteristically benign nomenclature of osteoblastoma, it sometimes recurs with the possibility of transforming into a malignant form after an incomplete resection.
  • However, it has not been clarified whether the adjacent bones should also be completely resected when magnetic resonance (MR) images reveal abnormal signal intensity in the bone marrow.
  • CASE DESCRIPTION: Presented in this case report is a 12-year-old boy with occipital tenderness associated with occipitoparietal bone tumor.
  • Neuroradiological studies demonstrated a solid tumor located in the occipital bone extending over the right parietal bone.
  • Magnetic resonance images further revealed abnormal signal intensity in the bone marrow of the entire occipital and bilateral parietal bones.
  • Macroscopically, the calvarial bone adjacent to the solid tumor appeared to be reddish, but it was not covering the entire area, contradicting the abnormal intensity found on the preoperative MR images.
  • Because histological examination did not clearly indicate tumor invasion at the margin of the resection site, no additional therapy was given.
  • Although MR images revealed abnormal intensity in the bone marrow of the surgical margin immediately after the operation, the intensity had been normalized by degrees and there was no evidence of recurrence during a follow-up period of 34 months.
  • This may suggest that bone marrow lesion showing abnormal intensity was edema rather than tumor invasion.
  • CONCLUSIONS: The authors conclude that total resection, including a bone marrow lesion, is not always necessary for benign osteoblastoma.
  • Macroscopic findings that show an abnormal color tone of the cortex could be a good indicator in revealing tumor activity invading bone marrow.
  • [MeSH-major] Magnetic Resonance Imaging. Occipital Bone / pathology. Osteoblastoma / pathology. Osteoblastoma / surgery. Skull Neoplasms / pathology. Skull Neoplasms / surgery
  • [MeSH-minor] Bone Marrow Neoplasms / pathology. Child. Humans. Male. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 16051019.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Hauptmann K, Melcher I, Schaser KD: [Differential diagnosis of intramedullary osteosarcomas]. Pathologe; 2008 Nov;29 Suppl 2:240-4
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  • [Title] [Differential diagnosis of intramedullary osteosarcomas].
  • Intramedullary high-grade osteosarcomas are aggressive tumors with a high metastatic capacity.
  • The many subtypes and variants of these tumors often make the differential diagnosis difficult.
  • Low-grade central osteosarcomas are a completely different tumor group.
  • Due to their strong similarity to benign bone tumors they are frequently misdiagnosed as such.
  • The correct diagnosis followed by radical surgery, however, is essential to reduce the high risk of local recurrences, typically seen for of these lesions.
  • [MeSH-major] Bone Neoplasms / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Biopsy. Bone and Bones / diagnostic imaging. Bone and Bones / pathology. Diagnosis, Differential. Humans. Neoplasm Recurrence, Local / diagnostic imaging. Neoplasm Recurrence, Local / pathology. Prognosis. Radiography

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  • (PMID = 18843492.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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85. Miller IJ, Blank A, Yin SM, McNickle A, Gray R, Gitelis S: A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases. Diagn Pathol; 2010;5:62
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  • [Title] A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases.
  • Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis.
  • Vascular invasion outside the boundary of the tumor can be seen.
  • Metastasis, with identical morphology to the primary tumor, occurs in a few percent of cases, usually to the lung.
  • On occasion GCTs of bone undergo frank malignant transformation to undifferentiated sarcomas.
  • Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation.
  • [MeSH-major] Bone Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local. Tibia / pathology
  • [MeSH-minor] Adult. Arthroplasty, Replacement, Knee. Biopsy. Bone Cements / therapeutic use. Chemotherapy, Adjuvant. Curettage. Humans. Immunohistochemistry. Male. Neoadjuvant Therapy. Reoperation. Thoracoscopy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20860830.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Cements
  • [Other-IDs] NLM/ PMC2954972
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86. Falcone G, Rossi ED, Maccauro G, de Santis V, Rosa MA, Capelli A, Fadda G: Diagnostic relevance of the immunohistochemical detection of growth factors in benign and malignant cartilaginous tumors. Appl Immunohistochem Mol Morphol; 2006 Sep;14(3):334-40
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  • [Title] Diagnostic relevance of the immunohistochemical detection of growth factors in benign and malignant cartilaginous tumors.
  • The goal of this study was to evaluate the diagnostic relevance of the expression of growth factors in cartilaginous tumors and to investigate on the possible correlation with grade, local recurrence, metastatic potential, and survival.
  • Expression of VEGF, PDGF, FGF1, TFGbeta2, TNFalpha, Ki-67, and p53 was analyzed in 21 cases of benign and malignant cartilaginous tumors using immunohistochemistry.
  • These data suggest a progressive modification in the biologic behavior of malignant cartilaginous tumors.

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  • (PMID = 16932026.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Growth Substances
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87. Ortakoglu K, Akcam T, Sencimen M, Karakoc O, Ozyigit HA, Bengi O: Osteochondroma of the mandible causing severe facial asymmetry: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):e21-8
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  • Osteochondroma is one of the most common benign tumors of bone.
  • The aim of the present study is to emphasize the importance of stereolithographic models in planning tumor surgery and how it affects the treatment planning, operation time and prognosis.
  • Based on the model evaluation, the tumor was conservatively resected and the condyle left intact, leaving no sequelae.

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  • (PMID = 17331758.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Hod N, Levi Y, Fire G, Cohen I, Ayash D, Somekh M, Horne T: Scintigraphic characteristics of non-ossifying fibroma in military recruits undergoing bone scintigraphy for suspected stress fractures and lower limb pains. Nucl Med Commun; 2007 Jan;28(1):25-33
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  • [Title] Scintigraphic characteristics of non-ossifying fibroma in military recruits undergoing bone scintigraphy for suspected stress fractures and lower limb pains.
  • INTRODUCTION: Non-ossifying fibroma (NOF) is the most common fibrous bone lesion in children and young adults.
  • This benign lesion is not a true neoplasm but is considered a developmental defect.
  • NOF that ossify can show increased uptake on bone scintigraphy.
  • AIM: To document the scintigraphic features of NOF in a group of military recruits undergoing bone scintigraphy for suspected stress fractures.
  • MATERIALS AND METHODS: Eighty-three military recruits, 67 male and 16 female, aged 18 to 22 years (mean, 19.4 years), who underwent Tc-methylene diphosphonate bone scans for suspected stress fractures or because of pain of the lower limbs had 91 focal lesions on bone scan which on further evaluation demonstrated characteristic radiographic findings of NOF.
  • We evaluated the anatomical site of the lesions, documented the intensity of uptake on bone scan and compared the findings with the radiographic description of the lesions.
  • All the NOF showed variable degrees of focal increased tracer uptake on bone scan.
  • The bone scan appearance of the focal lesions was: faint uptake in 29 (31.9%), mild uptake in 27 (29.7%), moderate uptake in 28 (30.7%) and intensely increased uptake in seven (7.7%).
  • CONCLUSIONS: Military recruits undergoing bone scan for suspected stress fracture might have incidental findings which require further evaluation.
  • Focal lesions on bone scan located about the knee in the lateral aspect of the distal femur or lateral aspect of the proximal tibia in the metaphyseal region of these bones are not compatible with the characteristic scintigraphic features of stress fracture.
  • During the healing phase of the NOF which commonly occur in the age range of this group, the lesion shows mild-to-moderate increased tracer uptake on bone scan.
  • Some NOF lesions are still indistinguishable from stress fracture or splints on bone scan.
  • [MeSH-major] Fibroma / pathology. Fractures, Stress / diagnosis. Ossification, Heterotopic / diagnosis. Radionuclide Imaging / methods
  • [MeSH-minor] Adolescent. Adult. Bone Diseases, Developmental / radiography. Bone and Bones / pathology. Female. Humans. Leg Bones / pathology. Male. Military Personnel. Pain. Radiopharmaceuticals / pharmacology. Technetium / pharmacology

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  • (PMID = 17159546.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 7440-26-8 / Technetium
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89. Lin SP, Fang YC, Chu DC, Chang YC, Hsu CI: Characteristics of cranial aneurysmal bone cyst on computed tomography and magnetic resonance imaging. J Formos Med Assoc; 2007 Mar;106(3):255-9
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  • [Title] Characteristics of cranial aneurysmal bone cyst on computed tomography and magnetic resonance imaging.
  • Aneurysmal bone cysts are benign bone tumors that most commonly occur in people younger than 30 years.
  • The tumor was soft, fragile, and pulsatile during surgery.
  • The patient was treated with en bloc resection of the tumor with cranioplasty.

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  • (PMID = 17389172.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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90. Fu K, Meng ZB, Li J, Li HC: [Repairing the defect of benign bone tumor with the coralline hydroxyapatite]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 May;33(5):421-4
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  • [Title] [Repairing the defect of benign bone tumor with the coralline hydroxyapatite].
  • OBJECTIVE: To observe the clinical effect of repairing bone defectin post-operation benign tumor with coralline hydroxyapatite(CHAP).
  • The CHAP was implanted into the lesion after bone tumor curettage to 25 patients.
  • The sizes of bone defect ranged from 0.8 cm x 0.5 cm x 0.5 cm to 10 cm x 3.5 cm x 2 cm.
  • X-ray showed that there was osteogenesis at the cortical bone 1 month post-operation.
  • There is corresponding synchronization between bone formation with CHAP biodegradation.
  • The CHAP is an excellent bone defect repairing material.
  • [MeSH-major] Bone Neoplasms / surgery. Ceramics. Giant Cell Tumor of Bone / surgery. Hydroxyapatites. Prostheses and Implants
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Regeneration. Bone Substitutes. Child. Female. Femur / surgery. Humans. Male. Middle Aged

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  • (PMID = 18544846.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / coralline hydroxyapatite
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91. Karkos PD, Khoo LC, Leong SC, Lewis-Jones H, Swift AC: Computed tomography and/or magnetic resonance imaging for pre-operative planning for inverted nasal papilloma: review of evidence. J Laryngol Otol; 2009 Jul;123(7):705-9
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  • BACKGROUND: Inverted nasal papilloma is a benign tumour with variable biological behaviour.
  • It is a unique neoplasm and is often difficult to manage, being characterised by a tendency to recur following excision, an association with malignancy and an ability to destroy bone.
  • Radiological diagnosis has traditionally been based on computed tomography, but it is often impossible to differentiate between polyps with entrapped debris and inverted nasal papilloma.
  • T2-weighted magnetic resonance imaging scans were able to distinguish tumour (intermediate signal) from inflammatory tissues (bright signal), but not post-operative scarring from recurrent tumour.
  • Magnetic resonance imaging is able to distinguish tumour from inflammation and is advocated as a better tool for recurrent tumour, but bone destruction of sinus walls is less easy to recognise, compared with computed tomography.
  • Evaluation of sinus tumours usually involves both imaging modalities, and inverted nasal papilloma should be included within this pathological group.
  • [MeSH-major] Nose Neoplasms / diagnosis. Papilloma, Inverted / diagnosis

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  • (PMID = 19216815.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
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92. Fabi A, Nuzzo C, Vidiri A, Ciccarese M, Felici A, Cattani F, Cognetti F: Bone and lung metastases from intracranial meningioma. Anticancer Res; 2006 Sep-Oct;26(5B):3835-7
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  • [Title] Bone and lung metastases from intracranial meningioma.
  • Fifteen percent of intracranial tumors are represented by meningiomas.
  • Meningioma is usually a benign neoplasm; malignant histology is rare and represents about 2-10% with a 43% incidence of metastasis.
  • A rare case of a woman with a relapse of intracranial meningioma in the right frontal lobe who subsequently developed simultaneous bone and intrapulmonary metastases is reported.
  • [MeSH-major] Bone Neoplasms / secondary. Brain Neoplasms / pathology. Lung Neoplasms / secondary. Meningioma / pathology


93. Dobashi Y, Watanabe H, Matsubara M, Yanagawa T, Raz A, Shimamiya T, Ooi A: Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours. J Pathol; 2006 Jan;208(1):44-53
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  • [Title] Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours.
  • In order to assess the involvement of autocrine motility factor (AMF) in mesenchymal tumours, AMF protein and mRNA expression was analysed in tumours, tumour-like lesions, and other lesions of bone and soft tissue.
  • Chordoid, chondroid, and muscular tumours revealed higher immunoreactivity in both benign and malignant tumours.
  • Generally, malignant tumours revealed higher expression of AMF than benign tumours of the same histopathological lineage, except for dermatofibroma/dermatofibrosarcoma protuberans.
  • In addition, higher expression of its mRNA may indicate higher levels of protein secretion and define a particularly aggressive group of tumours with high metastatic potential.
  • [MeSH-major] Bone Neoplasms / metabolism. Glucose-6-Phosphate / metabolism. Glucose-6-Phosphate Isomerase / analysis. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Immunoblotting / methods. Immunohistochemistry / methods. Neoplasm Metastasis. Neoplasm Proteins / analysis. Proteasome Inhibitors. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland.
  • (PMID = 16294294.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-51714
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Proteasome Inhibitors; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 56-73-5 / Glucose-6-Phosphate; EC 5.3.1.9 / Glucose-6-Phosphate Isomerase
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94. Carinci F, Piattelli A, Martinelli M, Palmieri A, Rubini C, Fioroni M, Scapoli L, Laino G, Caputi S, Becchetti A, Pezzetti F: Genetic profiling of central giant cell granuloma of the jaws. J Craniofac Surg; 2005 May;16(3):399-407
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  • Whether CGCG is a reactive lesion or a truly benign neoplasm remains undetermined, and the mechanism determining the onset of the disease remains unknown.
  • RNA extracted from a pool of three normal bone tissues was used as control.

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  • (PMID = 15915104.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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95. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy. Ann Surg; 2005 Sep;242(3):353-61; discussion 361-3
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  • METHODS: Differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms were identified by extracellular matrix and adhesion molecule cDNA array analysis and confirmed by real-time quantitative polymerase chain reaction (PCR).
  • RESULTS: By cDNA array analysis, ADAMTS8, ECM1, MMP8, PLAU, SELP, and TMPRSS4 were upregulated, and by quantitative PCR, ECM1, SELP, and TMPRSS4 mRNA expression was higher in malignant (n = 57) than in benign (n = 38) thyroid neoplasms (P< 0.002).
  • ECM1 and TMPRSS4 mRNA expression levels were independent predictors of a malignant thyroid neoplasm (P < 0.003).
  • The level of ECM1 mRNA expression was higher in TNM stage I differentiated thyroid cancers than in stage II and III tumors (P < or = 0.031).
  • [MeSH-major] Biomarkers, Tumor / genetics. Extracellular Matrix Proteins / genetics. Membrane Proteins / genetics. Serine Endopeptidases / genetics. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biopsy, Fine-Needle. Gene Expression. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16135921.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ECM1 protein, human; 0 / Extracellular Matrix Proteins; 0 / Membrane Proteins; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / transmembrane serine protease 2, human
  • [Other-IDs] NLM/ PMC1357743
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96. Robinson P: Hepatocellular carcinoma: development and early detection. Cancer Imaging; 2008;8 Spec No A:S128-31
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  • Nodules can be classified on dual contrast MRI as clearly malignant, clearly benign, or borderline (needing careful surveillance).
  • Pre-operative staging in surgical candidates should include CT of thorax, abdomen and pelvis and bone scintigraphy.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Early Diagnosis. Humans. Liver Cirrhosis / complications. Liver Cirrhosis / pathology. Liver Cirrhosis / physiopathology. Magnetic Resonance Imaging. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 18852086.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 9
  • [Other-IDs] NLM/ PMC2582507
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97. Klenke FM, Merkle T, Fellenberg J, Abdollahi A, Huber PE, Gebhard MM, Ewerbeck V, Sckell A: A novel model for the investigation of orthotopically growing primary and secondary bone tumours using intravital microscopy. Lab Anim; 2005 Oct;39(4):377-83
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  • [Title] A novel model for the investigation of orthotopically growing primary and secondary bone tumours using intravital microscopy.
  • Here is reported the development of an experimental model using intravital microscopy as a tool to orthotopically investigate malignant bone tumours.
  • Although up to 85% of the most frequently occurring malignant solid tumours, such as lung and prostate carcinomas, metastasize into the bone, and despite the knowledge that a tumour's course may be altered by its surrounding tissue, there is no adequate experimental model available enabling the investigation of orthotopically grown bone tumours in vivo.
  • Intravital microscopy is an internationally accepted experimental method, used in various acute and chronic animal models, that enables qualitative and quantitative analysis of the angiogenesis, microcirculation, growth behaviour, etc. of various benign and malignant tissues.
  • Severe combined immunodeficient mice were fitted with a cranial window preparation where the calvaria served as the site for orthotopic implantation of the solid human tumours Saos-2 osteosarcoma (primary) and A 549 lung carcinoma and PC-3 prostate carcinoma (secondary).
  • Histological assessment confirmed the data obtained in vivo, showing typical tumour growth with infiltration of the surrounding osseous and soft tissues.
  • This novel model serves as a valuable tool in understanding the biology of primary and secondary bone tumours in physiological and pathophysiological situations, with implications for the most areas of tumour therapy such as chemotherapy, radiation and antiangiogenesis.
  • [MeSH-major] Bone Neoplasms / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Animals. Lung Neoplasms / pathology. Male. Mice. Mice, SCID. Microscopy, Fluorescence. Microscopy, Video. Neoplasm Transplantation. Neovascularization, Pathologic / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 16197704.001).
  • [ISSN] 0023-6772
  • [Journal-full-title] Laboratory animals
  • [ISO-abbreviation] Lab. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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98. Zafatayeff-Hasbani S, Ducou Le Pointe H, Josset P, Damsin JP, Montagne JP: Intra-articular recurrence of benign chondroblastoma with articular involvement at initial presentation--a case report. Eur J Pediatr Surg; 2006 Aug;16(4):291-3
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  • [Title] Intra-articular recurrence of benign chondroblastoma with articular involvement at initial presentation--a case report.
  • Intra-articular and soft tissue recurrence occurred after treatment consisting of curettage and bone grafting.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Tibia
  • [MeSH-minor] Adolescent. Curettage. Epiphyses / pathology. Humans. Knee Joint. Male. Neoplasm Recurrence, Local. Neoplasm Seeding. Soft Tissue Neoplasms / pathology

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  • (PMID = 16981100.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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99. Guo Z, Wang Z, Li J, Li XD: [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors]. Zhonghua Wai Ke Za Zhi; 2008 Jun 15;46(12):895-9
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  • [Title] [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors].
  • OBJECTIVE: To evaluate the reconstructive effect of a new pattern of combined reconstruction after periacetabular tumor resections.
  • METHODS: Between March 2001 and March 2007, tumor resections and new pattern of combined reconstructions which consisted of screw-rod system, acetabular reinforcement shell, antibiotic cement and total hip arthroplasty techniques were performed in 23 patients with periacetabular tumors.
  • Seventeen patients had primary malignant tumors including 7 chondrosarcomas, 4 osteosarcomas, 2 Ewing sarcomas, 2 malignant fibrohistiocytomas, 1 malignant Schwannomas, and 1 synovial sarcoma.
  • Other primary tumors were 2 giant cell tumors and 1 aggressive osteoblastoma.
  • Three metastatic bone tumors were also included in this study, and the original sites were thyroid, breast, and ovary.
  • Three primary benign bone tumors belonged to stage III.
  • 8 months (range, 9-73 months) in the patients with primary tumors.
  • CONCLUSIONS: This new combined reconstruction is an effective way to rebuild pelvic ring and maintain hip function with low complication rate after periacetabular tumor resections.
  • [MeSH-major] Acetabulum. Bone Neoplasms / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Arthroplasty, Replacement, Hip. Bone Screws. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19035146.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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100. Rougraff BT: Bone graft alternatives in the treatment of benign bone tumors. Instr Course Lect; 2005;54:505-12
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  • [Title] Bone graft alternatives in the treatment of benign bone tumors.
  • Most bone grafting procedures are done during spinal fusion and to treat patients with skeletal trauma.
  • Very few studies have addressed the bone grafting of skeletal defects after benign bone tumor excision.
  • Contained defects have been treated with autogenous bone grafts, fresh-frozen allografts, freeze-dried allografts, demineralized bone matrix, and ceramic materials.
  • Additionally, bone morphogenetic proteins may provide a future treatment option for bone tumor reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods
  • [MeSH-minor] Bone Substitutes. Ceramics. Humans. Tissue Preservation / methods. Transplantation, Homologous

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  • (PMID = 15948475.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Number-of-references] 30
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