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1. Krishna SM, James S, Balaram P: Expression of VEGF as prognosticator in primary nasopharyngeal cancer and its relation to EBV status. Virus Res; 2006 Jan;115(1):85-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • VEGF, a potent endothelial cell mitogen and vascular permeability-inducing agent, plays a critical role in tumor growth and neo-vascularisation.
  • VEGF expression was assessed in 103 NPC and 26 benign adenoid lesions by immunohistochemistry and Epstein Bar Virus (EBV) presence by PCR using primers directed against EBNA-1 gene.
  • The localization of the virus to the tumour cells was confirmed by in situ hybridization using EBER in situ hybridization.
  • The results point towards the potential of the expression pattern of VEGF as a tumor marker for the early diagnosis of metastastic NPC and also show that presence of EBV is related to up regulation of VEGF.
  • [MeSH-minor] Biomarkers, Tumor. Epstein-Barr Virus Nuclear Antigens / genetics. Humans. Lymph Nodes / metabolism. Lymph Nodes / virology. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / virology. Polymerase Chain Reaction

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  • (PMID = 16139912.001).
  • [ISSN] 0168-1702
  • [Journal-full-title] Virus research
  • [ISO-abbreviation] Virus Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / EBV-encoded nuclear antigen 1; 0 / Epstein-Barr Virus Nuclear Antigens; 0 / Vascular Endothelial Growth Factor A
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2. Huang R, Jaffer S: Imprint cytology of metastatic sialoblastoma. A case report. Acta Cytol; 2003 Nov-Dec;47(6):1123-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Sialoblastoma is a rare, aggressive and potentially malignant perinatal/congenital tumor that recapitulates the developing salivary gland.
  • Imprint smears and frozen section of the mass were diagnostic of metastatic sialoblastoma.
  • The clusters contained admixed benign ductal cells and dense, metachromatic, magenta hyaline globular material with smooth, rounded outlines.
  • The differential diagnoses include neoplasms composed of either basaloid cells and/or admixed hyaline matrix material and included pleomorphic adenoma, basal cell adenoma and adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / secondary. Neoplasms, Glandular and Epithelial / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child, Preschool. Diagnosis, Differential. Disease Progression. Epithelial Cells / pathology. Female. Humans. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Parotid Gland / pathology. Parotid Gland / surgery. Treatment Outcome

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  • (PMID = 14674095.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Dalpa E, Gourvas V, Baritaki S, Miyakis S, Samaras V, Barbatis C, Sourvinos G, Spandidos DA: High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland. J Clin Virol; 2008 Jun;42(2):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Warthin's tumor is a common benign neoplasm of the salivary gland.
  • Human Herpes Virus 8 (HHV-8) is the etiologic agent for all forms of Kaposi's sarcoma (KS), and HHV-8 DNA is present in saliva, suggesting that non-sexual transmission is associated with latent infection of the salivary gland.
  • RESULTS: HHV-8 DNA was detected in 19 out of 43 (44%) salivary gland tumor samples.
  • Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens.
  • CONCLUSIONS: HHV-8 is frequently detected in adenoid salivary neoplasms, suggesting a significant role of the virus in the etiopathogenesis of the disease.

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  • (PMID = 18339579.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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4. Vuhahula EA: Salivary gland tumors in Uganda: clinical pathological study. Afr Health Sci; 2004 Apr;4(1):15-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SETTING: Makerere University, Faculty of Medicine, Department of Pathology.
  • METHODS: All epithelial tumors from major and minor salivary glands accessioned from 1979 to 1988 were analyzed in respect to sex and age of patients, anatomical location of the tumor and histological type.
  • The histological diagnosis of each individual tumor was based on the 1991 WHO classification of salivary gland tumors.
  • No tumor was implicated from the sublingual gland.
  • There were a total of 125 (46.6%) malignant tumors and 143 (53.4%) benign tumors.
  • The mean age of patients with malignant lesions (43.1 years; SD=16.75; median=44.00 years) was 9.6 years older than those with benign tumors (mean=33.5 years; SD=16.0; median=30.00 years).
  • Pleomorphic adenoma was the most common benign tumor (74.8%), followed by myoepithelioma (9.8%).
  • No Whartin's tumor was encountered.
  • The malignant tumors were dominated by adenoid cystic carcinoma (28.8%) followed by mucoepidermoid carcinoma (21.6%).
  • i) females are more affected than males, ii) there is a low proportion of tumors from the parotid gland and high proportion of tumors from the submandibular and minor salivary glands, iii) the parotid and minor salivary gland tumors have more probability of being malignant than those tumors from the submandibular gland iv) the newly categorized pathological entities are common and v) Whartin's tumor is extremely rare in black African population.
  • [MeSH-minor] Adolescent. Adult. African Continental Ancestry Group. Age Distribution. Aged. Aged, 80 and over. Child. Child, Preschool. European Continental Ancestry Group. Female. Humans. Infant. Male. Middle Aged. Neoplasm Metastasis. Sex Distribution. Uganda / epidemiology

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  • (PMID = 15126188.001).
  • [ISSN] 1729-0503
  • [Journal-full-title] African health sciences
  • [ISO-abbreviation] Afr Health Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Uganda
  • [Other-IDs] NLM/ PMC2141656
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5. Epivatianos A, Poulopoulos A, Kayavis I, Papanayotou P: Tumor-associated glycoprotein 72 (TAG-72) expression in salivary gland neoplasia: an immunohistochemical study using the monoclonal antibody (MAb) CC49. Oral Dis; 2000 Mar;6(2):112-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-associated glycoprotein 72 (TAG-72) expression in salivary gland neoplasia: an immunohistochemical study using the monoclonal antibody (MAb) CC49.
  • OBJECTIVES: The purpose of this study was to investigate immunohistochemically the expression of tumor-associated glycoprotein 72 (TAG-72) using the monoclonal antibody (MAb) CC49 in salivary gland neoplasia and normal salivary glands in an attempt to determine the potential usefulness of MAb CC49 in diagnostic and therapeutic applications.
  • MATERIALS AND METHODS: Eighty-six specimens (21 benign tumors, 41 malignant, and 24 normal salivary glands), fixed in 10% formalin and embedded in paraffin, were retrieved from the files of the Department of Oral Medicine and Oral Pathology at the Dental School of Aristotle University, Thessaloniki, Greece, and were retrospectively studied with hematoxylin and eosin and with the streptavidin-biotin-complex method using the MAb CC49.
  • Weak or no immunoreactivity was found in adenoid cystic carcinoma, basal cell adenocarcinoma, polymorphous low-grade adenocarcinoma, and normal parotid gland.
  • [MeSH-major] Antibodies, Monoclonal. Antibodies, Neoplasm. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Glycoproteins / analysis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Carcinoma / genetics. Carcinoma / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / pathology. Coloring Agents. Cystadenocarcinoma, Papillary / genetics. Cystadenocarcinoma, Papillary / pathology. Eosine Yellowish-(YS). Fluorescent Dyes. Gene Expression Regulation, Neoplastic. Hematoxylin. Humans. Immunoenzyme Techniques. Immunohistochemistry. Parotid Gland / cytology. Parotid Gland / metabolism. Retrospective Studies. Salivary Glands / cytology. Salivary Glands / metabolism. Salivary Glands, Minor / cytology. Salivary Glands, Minor / metabolism. Sublingual Gland / cytology. Sublingual Gland / metabolism. Submandibular Gland / cytology. Submandibular Gland / metabolism

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  • (PMID = 10702789.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / B72.3 antibody; 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Fluorescent Dyes; 0 / Glycoproteins; 0 / tumor-associated antigen 72; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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