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1. Ilić I, Randelović P, Ilić R, Dordević L, Radojković D: [Granular-cell tumor: a rare variant of mammary tumor]. Vojnosanit Pregl; 2008 Jun;65(6):488-91
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  • [Title] [Granular-cell tumor: a rare variant of mammary tumor].
  • BACKGROUND: Granular cell tumor (GCT) is a rare variant of mammary tumor beset with diagnostic dilemmas that may be resolved by using numerous, very complex, enzymohistochemical and immunohistochemical methods.
  • CASE REPORTS: We reported three female patients 16, 21 and 65 years old, operated on for mammary tumor at the Surgical Clinic of the School of Medicine in Nis, over the period of thirty years, 1977 to 2007.
  • During this period 14.022 mammary tumors were diagnosed, including these three cases.
  • These tumors had benign characteristics, without associated tumors in other localizations.
  • The tumors were analyzed by sets of histochemical, enzymohistochemical, immunohistochemical methods as well as ultrastructural examination.
  • The ultrastructural analysis confirmed that the tumor cells were enriched by lysosomes and consequential disorganization of cytoplasm.
  • CONCLUSION: The reported enzymo- and immunohistochemical combined methods provide a precise diagnosis and confirm the GCT's neural origin, which has been disputed for years.
  • [MeSH-major] Breast Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 18672708.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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2. Marret H, Sauget S, Giraudeau B, Body G, Tranquart F: Power Doppler vascularity index for predicting malignancy of adnexal masses. Ultrasound Obstet Gynecol; 2005 May;25(5):508-13
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  • OBJECTIVE: To assess the performance of a power Doppler vascularity index in the preoperative diagnosis of ovarian malignancy.
  • The tumor vascularity index (power Doppler index, PDI) was determined by quantification of the number of pixels in a defined region of interest according to the formula: number of colored pixels/(total number of pixels minus the number of pixels in the fluid or avascular areas).
  • It was estimated on selected frames of the tumors using an in-house color-quantifying program added to MATLAB 6.0 software.
  • A subjective visual score of power Doppler signals in the tumor was used to classify it as having low, moderate or high vascularity.
  • RESULTS: Histology identified 23 malignant and 78 benign lesions.
  • The PDI was considerably higher in malignant than in benign lesions (0.34 +/- 0.04 vs. 0.12 +/- 0.06; P < 0.001).
  • The PDI cut-off value to differentiate malignant from benign tumors was set at 0.265 (26.5% of the tumor being colored).
  • Logistic regression demonstrated that PDI was the best parameter for differentiating between malignant and benign tumors.
  • CONCLUSION: The power Doppler vascularity index obtained using customized color quantifying software has high diagnostic value in discriminating between benign and malignant adnexal masses.
  • [MeSH-major] Adnexa Uteri / ultrasonography. Adnexal Diseases / ultrasonography. Ovarian Neoplasms / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Diagnosis, Differential. Female. Humans. Middle Aged. Ovary / physiopathology. Ovary / ultrasonography. Pilot Projects. Prospective Studies. ROC Curve. Regional Blood Flow. Sensitivity and Specificity

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  • (PMID = 15846763.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Schlemmer M: Desmoid tumors and deep fibromatoses. Hematol Oncol Clin North Am; 2005 Jun;19(3):565-71, vii-viii
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  • [Title] Desmoid tumors and deep fibromatoses.
  • Desmoid tumors (also called deep fibromatoses) are rare benign tumors associated with pregnancy and Gardner syndrome.
  • These tumors are characterized by bland-appearing fibroblasts, indistinct margins, and an ability to cause pathology by local invasion and recurrence.
  • This article highlights the biology and clinical features of desmoid tumors.

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  • (PMID = 15939197.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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4. Garrido Abad P, Coloma del Peso A, Jiménez Gálvez M, Herranz Fernández LM, Arellano Gañán R, Reina Durán T: [Inflammatory myofibroblastic tumor. Case report]. Arch Esp Urol; 2008 Jan-Feb;61(1):62-5
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  • [Title] [Inflammatory myofibroblastic tumor. Case report].
  • [Transliterated title] Tumor miofibroblástico inflamatorio vesical. Aportación de un nuevo caso.
  • OBJECTIVE: To report one case of myofibroblastic bladder tumor.
  • METHODS/RESULTS: We report the case of a 30-year-old woman with recurrent urinary tract infections and incidental finding of a bladder mass after abdominal ultrasound.
  • After TUR, inflammatory myofibroblastic tumor of the bladder was diagnosed.
  • CONCLUSION: Myofibroblastic tumor (also known as inflammatory pseudotumor or pseudosarcoma) is a benign tumor with mesenchymal origin.
  • It must not be misdiagnosed as a malignant neoplasm.
  • [MeSH-major] Leydig Cell Tumor / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18405029.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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5. Roh JL, Park CI: Function-preserving parotid surgery for benign tumors involving the deep parotid lobe. J Surg Oncol; 2008 Jul 1;98(1):42-5
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  • [Title] Function-preserving parotid surgery for benign tumors involving the deep parotid lobe.
  • BACKGROUND: Parotid deep lobe tumors have usually been removed by total parotidectomy, which has functional and aesthetic side effects.
  • METHODS: We evaluated functional outcomes in 19 patients undergoing limited partial parotidectomy for benign tumors, 11 with deep lobe tumors and 8 with tumors involving both superficial and deep lobes, who underwent partial parotidectomy with preservation of normal glandular parenchyma and limited dissection of the facial nerve.
  • No patient had tumor recurrence after a median follow-up of 40 months.
  • CONCLUSION: Limited resection of benign tumors involving the parotid deep lobe may result in improved functional outcomes, including preserved salivary flow and beneficial cosmetic aspects, without compromising local tumor control.
  • [MeSH-major] Minimally Invasive Surgical Procedures / methods. Parotid Neoplasms / surgery

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  • (PMID = 18459159.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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6. Ignee A, Piscaglia F, Ott M, Salvatore V, Dietrich CF: A benign tumour of the liver mimicking malignant liver disease--cholangiocellular adenoma. Scand J Gastroenterol; 2009;44(5):633-6
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  • [Title] A benign tumour of the liver mimicking malignant liver disease--cholangiocellular adenoma.
  • OBJECTIVE: To describe three patients with liver lesions mimicking malignant tumours diagnosed finally, using contrast-enhanced ultrasound, as cholangiocellular adenoma (bile duct adenoma).
  • In two patients, no primary liver tumour was found, and in the third patient, previously resected for breast cancer, a tissue specimen was considered useful for characterizing tumour receptors for more targeted chemotherapy, the lesion being assumed metastatic in nature.
  • CONCLUSION: Cholangiocellular adenoma is a rare entity and can be a reason for possible false malignant diagnosis using contrast-enhanced ultrasound.
  • [MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Image Enhancement / methods. Middle Aged. Phospholipids. Risk Assessment. Sampling Studies. Sulfur Hexafluoride. Ultrasonography, Doppler, Color

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  • (PMID = 19396663.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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7. Mahajan S, Srikant N, Boaz K, George T: Osteoblastoma of maxilla with cartilaginous matrix: review of literature and report of a case. Singapore Dent J; 2007 Dec;29(1):12-8
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  • [Title] Osteoblastoma of maxilla with cartilaginous matrix: review of literature and report of a case.
  • Osteoblastoma is a rare benign neoplasm of jaws.
  • We report a case of a recurrent osteoblastoma in the maxilla of a 34-year-old male who presented with aggressive clinical and histologic features: namely root resorption, tooth mobility, involvement of maxillary sinus, chondroid formation, host bone trapping, and lack of osteoblastic rimming.
  • [MeSH-major] Cartilage / pathology. Maxillary Neoplasms / pathology. Osteoblastoma / pathology
  • [MeSH-minor] Adult. Connective Tissue / pathology. Diagnosis, Differential. Humans. Male. Maxillary Sinus / pathology. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Osteoblasts / pathology

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  • (PMID = 18472525.001).
  • [ISSN] 0377-5291
  • [Journal-full-title] Singapore dental journal
  • [ISO-abbreviation] Singapore Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 18
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8. Trovarelli S, Tallis V, Tripodi S, Miracco C, Ponchietti R: [Extratesticular intraescrotal neurofibroma: case report]. Arch Esp Urol; 2006 Nov;59(9):905-8
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  • [Transliterated title] Neurofibroma intraescrotal extratesticular: aportación de un caso.
  • METHODS: Clinical diagnosis of asymptomatic right scrotal lipoma and left symptomatic inguinal hernia carried the patient to the surgical treatment.
  • After the first surgical step of left hernia repair, we proceeded to the excision by an inguinoscrotal approach of a voluminous whitish neoplastic mass occupying the whole left scrotum and not involving homolateral testis.
  • RESULTS/CONCLUSIONS: The histopathologic diagnosis was of neurofibroma, a benign neoplasm of peripheral nerves which rarely occurs at genital level.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Neurofibroma / pathology. Scrotum

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  • (PMID = 17190215.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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9. Simon I, Rorive S, Kirkpatrick C, Roumeguere T, Nortier JL: Clear cell renal carcinoma presenting as a bleeding cyst in pregnancy: inaugural manifestation of a von Hippel-Lindau disease. Clin Nephrol; 2008 Mar;69(3):224-8
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  • [Title] Clear cell renal carcinoma presenting as a bleeding cyst in pregnancy: inaugural manifestation of a von Hippel-Lindau disease.
  • Von Hippel-Lindau (VHL) disease is a dominant autosomal disorder inducing the development of many tumors, such as hemangioblastomas in the central nervous system and retina, cysts or tumors (benign or malignant) in the kidneys and/or the pancreas.
  • We report the case of a pregnant woman who presented with a voluminous hemorrhagic cyst of the right kidney with an exophytic lesion detected in the lower median part of the cyst wall.
  • As an anamnestic inquiry resulted in a familial history of VHL disease, a screening imaging was performed and detected three medullary hemangioblastomas.
  • This case underlines the importance of screening procedures such as abdominal ultrasonography and medullary magnetic resonance imaging in all pregnant women with a familial history of VHL disease.
  • [MeSH-major] Carcinoma, Renal Cell / complications. Hematuria / etiology. Kidney Diseases, Cystic / diagnosis. Kidney Neoplasms / complications. Pregnancy Complications, Neoplastic. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Nephrectomy / methods. Pregnancy


10. Huang CF, Chiou SY, Wu MF, Tu HT, Liu WS, Chuang JC: Apparent diffusion coefficients for evaluation of the response of brain tumors treated by Gamma Knife surgery. J Neurosurg; 2010 Dec;113 Suppl:97-104
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  • [Title] Apparent diffusion coefficients for evaluation of the response of brain tumors treated by Gamma Knife surgery.
  • The authors hypothesized that loss of tumor cells after Gamma Knife surgery (GKS) may alter the ADC value and used diffusion weighted MR imaging (DW imaging) to evaluate cellular changes in brain tumors to detect their treatment response and the efficacy of GKS.
  • Follow-up MR images and clinical outcomes were reviewed at 3-month intervals for metastatic lesions and at 6-month intervals for benign tumors.
  • Calcification (p = 0.006) and tumor recurrence (p = 0.025) significantly prevented a rise in the ADC level.The mean ADC value for all solid acoustic neuromas was 1.06 ± 0.17 × 10-3 mm2/sec before GKS.
  • At the last mean MR imaging follow-up there appeared to be tumor enlargement in 3 patients (12.5%); however, since the ADC values in these patients were significantly higher than the preradiosurgery values, the finding was considered to be a sign of radiation necrosis rather than tumor recurrence.
  • The mean ADC value of metastatic tumors was 1.05 ± 0.12 × 10-3 mm2/sec before GKS.
  • Magnetic resonance imaging showed that 89% of these tumors had been controlled by GKS.
  • In some patients in whom imaging findings are equivocal, ADC values may also be used to distinguish radiation-induced necrosis from tumor recurrence.(DOI: 10.3171/2010.7.GKS10864)
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / surgery. Diffusion Magnetic Resonance Imaging / methods. Image Processing, Computer-Assisted / methods. Radiosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Echo-Planar Imaging. Female. Humans. Male. Meningioma / pathology. Meningioma / surgery. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 21222290.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 13 expression in salivary gland tumors. Int J Biol Markers; 2006 Apr-Jun;21(2):106-10
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  • [Title] Human kallikrein 13 expression in salivary gland tumors.
  • The aim of this study was to determine whether hK13 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of hK13.
  • Ductal cells and cells lining duct-like structures showed a higher intensity of staining than non-ductal cells in most tumors.
  • Tumors which exhibited only non-ductal cells also exhibited cytoplasmic staining.
  • In conclusion, we demonstrate the high expression of hK13 in several common salivary gland tumors.
  • [MeSH-major] Biomarkers, Tumor. Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic. Kallikreins / biosynthesis. Mouth Mucosa / metabolism. Salivary Gland Neoplasms / genetics

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  • (PMID = 16847813.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK13 protein, human; EC 3.4.21.- / Kallikreins
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12. Bulun SE, Imir G, Utsunomiya H, Thung S, Gurates B, Tamura M, Lin Z: Aromatase in endometriosis and uterine leiomyomata. J Steroid Biochem Mol Biol; 2005 May;95(1-5):57-62
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  • Endometrial tissue from uterine disease-free women does not exhibit aromatase activity.
  • Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium.
  • [MeSH-major] Aromatase / metabolism. Endometriosis / enzymology. Leiomyoma / enzymology. Uterine Neoplasms / enzymology

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  • (PMID = 16024248.001).
  • [ISSN] 0960-0760
  • [Journal-full-title] The Journal of steroid biochemistry and molecular biology
  • [ISO-abbreviation] J. Steroid Biochem. Mol. Biol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD38691; United States / NICHD NIH HHS / HD / HD46260
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / Estrogens; EC 1.14.14.1 / Aromatase
  • [Number-of-references] 32
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13. Hossain D, Meiers I, Qian J, MacLennan GT, Bostwick DG: Prostatic stromal hyperplasia with atypia: follow-up study of 18 cases. Arch Pathol Lab Med; 2008 Nov;132(11):1729-33
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  • RESULTS: Prostatic stromal hyperplasia with atypia consists of 1 or more ill-defined, uncircumscribed, hyperplastic stromal nodules, with variable numbers of atypical, bizarre giant cells, with vacuolated nuclei, smudged chromatin, and frequent multinucleation infiltrating around benign acini.
  • CONCLUSIONS: Prostatic stromal hyperplasia with atypia is a rare, benign lesion, composed of degenerative myocytes with atypia that is histologically and clinically reminiscent of benign counterparts in the myometrium, breast, vulva, vagina, and elsewhere.
  • Recognition of this distinctive entity should allow separation from phyllodes tumor and sarcoma of the prostate.
  • The phrase stromal tumor of uncertain malignant potential is inappropriate for this benign tumor, and its use is discouraged.
  • [MeSH-major] Prostatic Hyperplasia / diagnosis. Prostatic Hyperplasia / pathology. Stromal Cells / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Cell Nucleus / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Muscle Cells / metabolism. Muscle Cells / pathology. Receptors, Androgen / metabolism. Retrospective Studies. Vimentin / metabolism

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  • (PMID = 18976007.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Vimentin
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14. Passman C, Urban D, Klemm K, Lockhart M, Kenney P, Kolettis P: Testicular lesions other than germ cell tumours: feasibility of testis-sparing surgery. BJU Int; 2009 Feb;103(4):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular lesions other than germ cell tumours: feasibility of testis-sparing surgery.
  • OBJECTIVE: To review all non-germ-cell testicular lesions presenting at our institution and to determine the feasibility of testis-sparing surgery for these patients.
  • Patients with atrophy, germ cell tumours, infection or torsion were excluded.
  • The study comprised men who had radical orchidectomy for suspected germ-cell tumour but had other final pathology, and those where testis-sparing surgery was attempted for a presumed benign lesion.
  • The lesions could be categorized as inflammatory (three hyalinized fibrosis, two sarcoidosis, one chronic inflammation), cystic (one epidermoid cyst, one unilocular cyst), benign neoplasms (two adenomatoid tumours, one Leydig cell tumour, one capillary haemangioma) or malignant neoplasms (one lymphoma).
  • In the other five, testis-sparing surgery was not attempted because the preoperative impression was that of a germ cell tumour.
  • CONCLUSION: Testis-sparing surgery might be possible if there is significant suspicion of a benign lesion.
  • [MeSH-minor] Adolescent. Adult. Aged. Feasibility Studies. Humans. Leydig Cell Tumor / pathology. Leydig Cell Tumor / surgery. Leydig Cell Tumor / ultrasonography. Male. Middle Aged. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18793303.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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15. Rotman S, Déruaz C, Venetz JP, Chaubert P, Benhattar J, Meuwly JY, Jichlinski P, Guillou L, Moll S, Pascual M, Lemoine R: De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin. Hum Pathol; 2006 Apr;37(4):481-7
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  • [Title] De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin.
  • In the general population, renal cell carcinoma (RCC) is a relatively common neoplasm; however, the papillary RCC subtype is infrequent and represents only 10 to 15% of all RCC.
  • Angiomyolipoma is a well-known common benign tumor.
  • In transplant recipients, RCC can develop in native kidneys, but its occurrence "de novo" in the renal allograft is very rare with an estimated incidence of less than 0.5%.
  • We report here the case of a 39-year-old woman who underwent cadaveric renal transplantation in 1990.
  • She underwent allograft nephrectomy and the histologic findings revealed that one of the tumors was a chromophilic (type 1) papillary RCC (2.5 cm in diameter) and the other, an angiomyolipoma (1.5 cm).
  • Microsatellite analysis of the allograft, as compared with the recipient peripheral blood leukocytes, demonstrated that the 2 tumors (1 malignant and 1 benign) were of donor origin.
  • To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft.
  • [MeSH-major] Angiomyolipoma / etiology. Carcinoma, Renal Cell / etiology. Kidney Neoplasms / etiology. Kidney Transplantation / adverse effects. Tissue Donors
  • [MeSH-minor] Adult. Cadaver. Female. Humans. Male. Microsatellite Repeats. Neoplasms, Multiple Primary. Nephrectomy. Postoperative Complications. Reoperation


16. Ogbole G, Kazaure I, Anas I: Quadrigeminal plate cistern lipoma. BMJ Case Rep; 2009;2009
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  • Intracranial lipomas are rare benign neoplasms accounting for <0.1% of all primary brain tumours.
  • Most lipomas were incidentally detected by autopsy or computed tomography (CT).These slow growing benign lesions are usually asymptomatic and rarely require surgery.
  • We report the case of a 70-year-old Nigerian woman who presented with persistent headaches following involvement in a road traffic accident 20 days previously.

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  • (PMID = 22190982.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027879
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17. Hedayati P, VanSonnenberg E, Shamos R, Gillespie T, McMullen W: Treatment of symptomatic focal nodular hyperplasia with percutaneous radiofrequency ablation. J Vasc Interv Radiol; 2010 Apr;21(4):582-5
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  • The authors report a case of a 21-year-old woman taking oral contraceptives for severe dysmenorrhea who presented with a hepatic mass and worsening right upper quadrant pain.
  • The ablation proved to be a safe and effective alternative to surgery to treat the benign tumor, and permitted more aggressive therapy of the dysmenorrhea.
  • [MeSH-major] Catheter Ablation / methods. Liver Neoplasms / radiography. Liver Neoplasms / surgery

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  • [Copyright] Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20138547.001).
  • [ISSN] 1535-7732
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Moaath A, Raed E, Mohammad R, Mohammad S: Lipoblastoma: a rare mediastinal tumor. Ann Thorac Surg; 2009 Nov;88(5):1695-7
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  • [Title] Lipoblastoma: a rare mediastinal tumor.
  • Lipoblastoma is a rare benign mesenchymal tumor of embryonal fat that occurs almost exclusively in infants and children less than age 3.
  • It is a benign tumor with a high recurrence rate.
  • We emphasize that this rare mediastinal tumor should be included in the differential diagnosis of infants having a mediastinal mass.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Neoplasms, Adipose Tissue / diagnosis

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  • (PMID = 19853146.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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19. Grosheva M, Gerharz M, Bovenschulte H, Beutner D: [Adult multilocular rhabdomyoma as a rare cause of dysphagia]. Laryngorhinootologie; 2008 Sep;87(9):651-3
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  • [Transliterated title] Multilokuläre adulte Rhabdomyome als seltene Ursache einer Dysphagie.
  • BACKGROUND: Adult rhabdomyoma is a benign tumor of the cardial und skeletal muscle system.
  • After complete surgical resection, histological investigation confirmed the diagnosis of a multilocular adult rhabdomyoma.
  • CONCLUSION: Rhabdomyoma as a benign lesion could occur multilocular and simulate metastasis of a malign formation.
  • [MeSH-major] Deglutition Disorders / etiology. Head and Neck Neoplasms. Rhabdomyoma

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  • (PMID = 18833645.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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20. Daponte A, Kostopoulou E, Kollia P, Papamichali R, Vanakara P, Hadjichristodoulou C, Nakou M, Samara S, Koukoulis G, Messinis IE: L1 (CAM) (CD171) in ovarian serous neoplasms. Eur J Gynaecol Oncol; 2008;29(1):26-30
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  • [Title] L1 (CAM) (CD171) in ovarian serous neoplasms.
  • PURPOSE OF THE INVESTIGATION: The evaluation of L1 (CAM) as a tumor progression marker and as a prognostic factor in serous ovarian tumors.
  • METHODS: L1 (CAM) protein expression was assessed by immunohistochemistry and Western blot in serous ovarian tumors [cystadenomas (n = 20), borderline tumors (n = 14) and carcinomas (n = 47)], and was correlated with stage,grade, progression-free survival time (PFS) and overall survival.
  • It increased from benign tumors to early carcinomas and to advanced stage carcinomas progressively and significantly.
  • In Stage III G3 carcinoma patients, low L1 (CAM) expressing tumors exhibited better response to chemotherapy and were associated with statistically significantly longer PFS (p = 0.002).
  • CONCLUSION: L1 (CAM) expression represents a novel diagnostic marker in serous ovarian neoplasms that shows characteristics of tumor progression.
  • [MeSH-major] Biomarkers, Tumor. Disease-Free Survival. Neoplasms, Cystic, Mucinous, and Serous / metabolism. Neural Cell Adhesion Molecule L1 / metabolism. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Neoplasm Staging

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  • (PMID = 18386459.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neural Cell Adhesion Molecule L1
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21. Damadoglu E, Salturk C, Takir HB, Ertugrul M, Yilmaz A, Atasalihi A, Yilmaz A: Mediastinal thymolipoma: an analysis of 10 cases. Respirology; 2007 Nov;12(6):924-7
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  • Thymolipoma is a benign tumour composed of thymic elements and adipose tissue.
  • Thymolipomas are unusual tumours and may be associated with myasthenia gravis.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Thymoma / diagnosis

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  • (PMID = 17986126.001).
  • [ISSN] 1323-7799
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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22. Hong TH, Lee SK, You YK, Kim JG: Single-port laparoscopic partial splenectomy: a case report. Surg Laparosc Endosc Percutan Tech; 2010 Oct;20(5):e164-6
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  • With the better understanding of the importance of the spleen as a primary organ of the human immune system, there has been an increased interest in performing the partial splenectomy for a number of indications such as nonparasitic cysts, benign tumors, staging of lymphomas, etc.
  • Moreover, laparoscopic partial splenectomy has been gaining more interest as the recommended approach for benign splenic disorders to preserve the splenic function with very low recurrence rates.
  • Here, we describe a feasible method of single-port laparoscopic partial splenectomy for treating a benign splenic cyst that was located in the upper medial aspect of the spleen.

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  • (PMID = 20975492.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Gorgun M, Sezer TO, Kirdok O: Laparoscopic resection of retroperitoneal schwannoma near the inferior vena. Ann Vasc Surg; 2010 May;24(4):551.e1-4
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  • BACKGROUND: Schwannomas are usually benign tumors that arise from the schwann cells in the neural sheaths of peripheral nerves.
  • We report a successfully resected retroperitoneal benign schwannoma near the inferior vena cava (IVC) using laparoscopic surgery.
  • Magnetic resonance imaging confirmed the existence of a round, sharply demarcated retroperitoneal solid tumor, 42 x 52 mm in size, located between the anterior of the right kidney and the IVC, which was compressed but still patent.
  • CONCLUSION: Laparoscopic surgery is very useful and feasible in the diagnosis and treatment of retroperitoneal schwannoma, with minimal invasiveness and early postoperative recovery.
  • [MeSH-major] Laparoscopy. Neurilemmoma / surgery. Retroperitoneal Neoplasms / surgery

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  • [Copyright] Copyright 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20144535.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Ishoo E: Intramuscular myxoma presenting as a rare posterior neck mass in a young child: case report and literature review. Arch Otolaryngol Head Neck Surg; 2007 Apr;133(4):398-401
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  • Intramuscular myxoma (IMM) is an uncommon benign tumor that presents as a slow-growing, deep-seated mass confined to the skeletal muscle.
  • These tumors most often present as painless, deep-seated intramuscular masses that may exhibit symptoms of compression of surrounding structures.(1) I report a case of a 22-month-old girl with an IMM in the posterior cervical triangle.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Myxoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17438256.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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25. Chien AL, Song DH, Stein SL: Two young girls with lipoblastoma and a review of the literature. Pediatr Dermatol; 2006 Mar-Apr;23(2):152-6
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  • Lipoblastoma is an uncommon, benign tumor of embryonic adipose tissue that occurs predominantly in the pediatric population.
  • Biopsy of the lesion is standard for diagnosis, as clinical and radiologic diagnoses can be misleading.
  • Both tumors were excised and subsequent gross and histopathologic examination demonstrated features of lipoblastoma.
  • [MeSH-major] Lipoma / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Female. Groin. Heel. Humans. Infant

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  • (PMID = 16650226.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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26. Lai TK, Chung CH, Chin AC, Szeto PS, Wong WC, Chan RY, Huang HY, Ng WF: Magnetic resonance imaging for ureteral fibroepithelial polyp. Hong Kong Med J; 2008 Oct;14(5):408-10
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  • Ureteric tumours are rare and most of them are malignant.
  • Of benign tumours, ureteral fibroepithelial polyps are the most common but are still considered clinical rarities.
  • In the past, most benign ureteric tumours were only diagnosed after surgical removal.
  • Non-contrast enhanced magnetic resonance urography can produce an image comparable to an intravenous urogram without use of intravenous water-soluble contrast.
  • Nevertheless, a definitive diagnosis relies on ureteroscopic examination with biopsy.
  • When a non-obstructive polyp is being managed conservatively, imaging is helpful for monitoring.

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  • (PMID = 18840916.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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27. Wang X, Pogue BW, Jiang S, Dehghani H, Song X, Srinivasan S, Brooksby BA, Paulsen KD, Kogel C, Poplack SP, Wells WA: Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography. J Biomed Opt; 2006 Jul-Aug;11(4):041106
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  • Then the method was used in NIR patient images, and it indicates that for a cancer tumor, the effective scatterer size is smaller than the background breast values and the effective number density is higher.
  • In contrast, for benign tumor patients, there is not a significant difference in effective scatterer size or number density between tumor and normal tissues.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Infrared Rays. Refractometry / methods. Tomography, Optical / methods

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  • (PMID = 16965134.001).
  • [ISSN] 1083-3668
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01CA80139; United States / NCI NIH HHS / CA / U54CA105480
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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28. Chen Y, Tian K, Geng N, Yang MZ, Zhang WP: [The expression of matrix metalloproteinases and their tissue inhibitors in pleomorphic adenoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jan;40(1):58-61
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  • OBJECTIVE: To examine the expression of MMPs and TIMPs in pleomorphic adenoma of salivary gland and to investigate the relationship between the expression and the biological behaviour of the tumor.
  • Immunohistochemistry for MMP-2, MMP-9, TIMP-1, TIMP-2 and gelatin zymography analysis were performed in these 23 cases and in 6 malignant and 6 benign salivary gland tumors.
  • There was no significant difference in expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 between the salivary malignant tumor and active pleomorphic adenoma, also between the salivary benign tumor and common pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Salivary Gland Neoplasms / metabolism. Tissue Inhibitor of Metalloproteinase-1 / metabolism. Tissue Inhibitor of Metalloproteinase-2 / metabolism

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  • (PMID = 15774155.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinase-1; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.24 / MMP2 protein, human; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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29. Singh R, Jain M, Siwach R, Rohilla RK, Kaur K: Unusual presentation of bizarre parosteal osteochondromatous lesion of the second toe (Nora's lesion). Foot Ankle Spec; 2010 Dec;3(6):347-51
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  • Bizarre parosteal osteochondromatous proliferation (BPOP) of bone is a rare benign neoplasm.
  • Although local excision of the tumor is the treatment of choice, the authors resorted to ray excision, as gangrenous changes and ulceration were present and there was the possibility of malignant change.
  • [MeSH-major] Bone Neoplasms / pathology. Foot Ulcer / pathology. Osteochondroma / pathology. Periosteum / pathology. Toes / pathology

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  • (PMID = 20624925.001).
  • [ISSN] 1938-7636
  • [Journal-full-title] Foot & ankle specialist
  • [ISO-abbreviation] Foot Ankle Spec
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. de Koning HD, Bovenschen HJ: Two adjacent nodules on the leg. Dermatol Online J; 2010;16(6):13
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  • Poroma is a rare benign neoplasm (derived from the intraepidermal part of the eccrine or apocrine duct), which may clinically mimic malignant tumors such as (amelanotic) malignant melanoma and porocarcinoma.
  • Histopathological examination is the key to the correct diagnosis, which is illustrated in the present case, in which a pigmented basal cell carcinoma and a poroma are in close proximity to each other.
  • Despite a clinical differential diagnosis of melanoma, histopathology showed the typical characteristics of a poroma, a rare but much more favorable tumor.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Leg. Poroma / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 20579468.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Han B, Jiang G, Wang H, He W, Liu M, Song N: Benign clear cell tumor of the lung. Ann Thorac Surg; 2010 Jun;89(6):2012-4
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  • [Title] Benign clear cell tumor of the lung.
  • Clear cell tumor of the lung is a rare benign tumor.
  • Herein, we present a case of a 51-year-old man who had an abnormal pulmonary nodule occasionally found on chest roentgenogram.
  • The patient underwent a lobectomy for the tumor.
  • The pathologic report supported the diagnosis of clear cell tumor of the lung.
  • [MeSH-major] Lung Neoplasms

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20494071.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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32. Uysal A, Sungur N, Koçer U, Cöloğlu H, Oruç M, Yalta T: Neuromuscular hamartoma of the occipital nerve: clinical report. J Craniofac Surg; 2005 Jul;16(4):740-2
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  • Neuromuscular hamartoma is a rare benign tumor consisted of well-differentiated striated muscle fibers within mature neural elements.
  • Though most cases are composed of solitary masses associated with major peripheral nerves, multiple tumors or subcutaneous tumors without any association with peripheral nerves have also been reported.
  • There have been no reports of this tumor in association with the occipital nerve.

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  • (PMID = 16077331.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Suzuki M, Sakurai H, Seno S, Hoshi J, Ogawa T, Arikata M, Tojima I, Kitanishi T, Tanaka H, Shimizu T: [Endoscopic resection of benign and malignant tumors in the nasal cavity and paranasal sinus]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Jul;108(7):724-33
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  • [Title] [Endoscopic resection of benign and malignant tumors in the nasal cavity and paranasal sinus].
  • Endoscopic resection of nasal and paranasal sinus tumors is more aesthetic and less invasive than conventional resection, such as Luc's operation and lateral rhinotomy.
  • We clarified the effect of radical endoscopic tumor excision and the control of local bleeding hazardous in endoscopic surgery.
  • Subjects were patients with benign lesions in the nasal cavity, medial wall of the maxillary sinus, ethmoid sinus, and/or sphenoid sinus without concurrent malignant lesions.
  • Although patients selection for malignant tumor excision was based on (1) possible en bloc resection, (2) low-grade malignant tumors, and (3) tumors in the nasal cavity and adjoining paranasal sinus, the final decision was made individual.
  • Subjects were 23 patients with benign tumor (10 inverted papilloma, 9 hemangioma, 2 juvenile angiofibroma, and 2 other tumors) and 4 with malignant tumor (olfactory neuroblastoma, acinic cell carcinoma, squamous cell carcinoma, and chondroid chordoma) in the nasal and paranasal sinus.
  • The tumor was resected en bloc except for patients with inverted papilloma (2 cases) and chondroid chordoma.
  • Recurrence in benign tumors was zero during a mean observation of 21 months.
  • The endoscopic excision of benign lesions in the nasal and paranasal sinus is thus as effective as conventional radical surgery.
  • [MeSH-major] Endoscopy. Nasal Cavity. Nose Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 16107047.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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34. Liu J, Zheng S, Yu JK, Zhang JM, Chen Z: Serum protein fingerprinting coupled with artificial neural network distinguishes glioma from healthy population or brain benign tumor. J Zhejiang Univ Sci B; 2005 Jan;6(1):4-10
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  • [Title] Serum protein fingerprinting coupled with artificial neural network distinguishes glioma from healthy population or brain benign tumor.
  • To screen and evaluate protein biomarkers for the detection of gliomas (Astrocytoma grade I-IV) from healthy individuals and gliomas from brain benign tumors by using surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) coupled with an artificial neural network (ANN) algorithm.
  • SELDI-TOF-MS protein fingerprinting of serum from 105 brain tumor patients and healthy individuals, included 28 patients with glioma (Astrocytoma I-IV), 37 patients with brain benign tumor, and 40 age-matched healthy individuals.
  • An accuracy of 95.7%, sensitivity of 88.9%, specificity of 100%, positive predictive value of 90% and negative predictive value of 100% were obtained in a blinded test set comparing gliomas patients with healthy individuals; an accuracy of 86.4%, sensitivity of 88.9%, specificity of 84.6%, positive predictive value of 90% and negative predictive value of 85.7% were obtained when patient's gliomas was compared with benign brain tumor.
  • The high sensitivity and specificity achieved by the use of selected biomarkers showed great potential application for the discrimination of gliomas patients from healthy individuals and gliomas from brain benign tumors.
  • [MeSH-major] Astrocytoma / blood. Astrocytoma / diagnosis. Biomarkers, Tumor / blood. Brain Neoplasms / blood. Brain Neoplasms / diagnosis. Diagnosis, Computer-Assisted / methods. Neoplasm Proteins / blood. Peptide Mapping / methods

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  • [Cites] CA Cancer J Clin. 2003 Jan-Feb;53(1):5-26 [12568441.001]
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  • (PMID = 15593384.001).
  • [ISSN] 1673-1581
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Controlled Clinical Trial; Letter; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC1390751
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35. Rosato L, Mondini G, Serbelloni M, Bertone P, Orlassino R, Cossavella D: [Intra-abdominal desmoid tumors: rare but important disease]. G Chir; 2007 Jan-Feb;28(1-2):20-4
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  • [Title] [Intra-abdominal desmoid tumors: rare but important disease].
  • [Transliterated title] I tumori desmoidi intra-addominali: una patologia rara, mai importante.
  • Desmoid tumors are rare benign neoplasms with high tendency to local recurrence, and they can be divided into extra- and intra-abdominal types (mesenteric fibromatosis).
  • Six patients (3 men and 3 women) affected by extra-abdominal desmoid tumors have been treated with radical excision.
  • 1) a 55 years old man admitted for acute abdomen and submitted, in emergency, to a laparotomy with excision of a mesenteric abscess including a jejunal loop at about one meter from Treitz;.
  • 2) 52 years old man, submitted to an elective excision of a capsulated neoplasm of the little omentum, which had caused an oppressive abdominal pain.
  • In both cases the hystological diagnosis has been desmoid tumor.
  • Surgical treatment of desmoid tumors must aim at radical excision to avoid frequent recurrences (25-65%); these have stimulated the research of other kinds of treatments, since a new surgical operation itself can lead to a further recurrence.
  • Radiotherapy has been investigated with results in 79-96% of cases, antiestrogenic therapy has been used with success in 51% of patients, and high dose tamoxifen seemed to obtain a stable disease in non operable cases.
  • Non steroidal anti-inflammatory drugs have been experimented in association with tamoxifen and chemotherapy.
  • Conclusive results on the efficacy of these treatments have not been obtained yet, because of the rarity of the desmoid tumors even in greater Centres.
  • [MeSH-major] Fibromatosis, Abdominal / surgery. Mesentery. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Abdominal Neoplasms / pathology. Abdominal Neoplasms / surgery. Aged. Female. Fibromatosis, Aggressive / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17313728.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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36. Shcherbakov PL, Bystrovskaia EV, Dolgasheva GM, Orlova IuN: [Endosonography in the diagnostics of non-epithelial tumors of the esophagus, stomach and duodenum]. Eksp Klin Gastroenterol; 2010;(10):29-31
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  • [Title] [Endosonography in the diagnostics of non-epithelial tumors of the esophagus, stomach and duodenum].
  • Non-epithelial tumors account for 5% of all neoplasms of the gastrointestinal (GI) tract, most often have no clinical manifestations and they are finding during the endoscopy.
  • Endoscopic ultrasonography (EUS) significantly expands the possible differential diagnosis of submucosal formations on the basis of their ultrasound characteristics.
  • The article presents the literature and personal experience of differential diagnosis of non-epithelial tumors, and benign formations of the esophagus, stomach and duodenum wall.
  • [MeSH-major] Duodenal Neoplasms / ultrasonography. Endosonography / methods. Esophageal Neoplasms / ultrasonography. Stomach Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Mucous Membrane / pathology. Mucous Membrane / ultrasonography

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  • (PMID = 21434368.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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37. Sherrod QJ, Chiu MW, Gutierrez M: Multiple pilomatricomas: cutaneous marker for myotonic dystrophy. Dermatol Online J; 2008;14(7):22
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  • Pilomatricoma (calcifying epithelioma of Malherbe) is a benign tumor of hair matrix derivation.
  • Since the onset of MPs may precede the signs of myotonic dystrophy, they can serve as potential early cutaneous markers for this systemic disease.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hair Diseases / pathology. Myotonic Dystrophy / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18718206.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Boo YJ, Kim J, Kim JH, Kim CS, Suh SO: Inflammatory myofibroblastic tumor of the kidney in a child: report of a case. Surg Today; 2006;36(8):710-3
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  • [Title] Inflammatory myofibroblastic tumor of the kidney in a child: report of a case.
  • Inflammatory myofibroblastic tumor (IMT), also known as inflammatory pseudotumor, is an uncommon benign tumor that has been reported in various locations throughout the body, but rarely in the kidney.
  • Renal IMT in children is difficult to differentiate from a malignancy such as Wilms' tumor.
  • We report a case of a 9-year old girl with a left renal mass mimicking malignancy on preoperative diagnostic images, which was pathologically revealed to be an IMT.
  • We review the literature and discuss the pathophysiology and clinical features of this unusual tumor.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Kidney Diseases / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Kidney Neoplasms / diagnosis

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  • (PMID = 16865515.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 37
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39. Gershtein ES, Levkina NV, Digayeva MA, Laktionov KP, Tereshkina IV, Kushlinsky NE: Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms. Bull Exp Biol Med; 2010 Oct;149(5):628-31
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  • [Title] Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms.
  • The content of matrix metalloproteinases 7 and 9 was significantly increased, while the content of metalloproteinase 2 was reduced in ovarian cancer tissue compared to benign tumors.
  • A significant positive correlation between serum levels of matrix metalloproteinases 7 and 9 and tissue inhibitor of metalloproteinases-1 in patients with ovarian cancer and the size of primary tumor (ultrasound examination) and a positive correlation between these parameters and the concentration of classical ovarian cancer marker CA-125 were demonstrated.
  • [MeSH-major] Biomarkers, Tumor / blood. Matrix Metalloproteinase 2 / blood. Matrix Metalloproteinase 7 / blood. Matrix Metalloproteinase 9 / blood. Ovarian Neoplasms / blood. Tissue Inhibitor of Metalloproteinase-1 / blood

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  • (PMID = 21165404.001).
  • [ISSN] 1573-8221
  • [Journal-full-title] Bulletin of experimental biology and medicine
  • [ISO-abbreviation] Bull. Exp. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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40. Coppens JR, Couldwell WT: Staged use of the transsphenoidal approach to resect superior third ventricular craniopharyngiomas. Minim Invasive Neurosurg; 2010 Feb;53(1):40-3
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  • INTRODUCTION: Craniopharyngiomas are benign tumors, usually originating from the infundibulum or tuber cinereum.
  • CASE REPORT: The authors describe the use of an extended transsphenoidal approach as a second-stage operation to resect the intraventricular component of a large craniopharyngioma in an illustrative case.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Neuroendoscopy / methods. Pituitary Neoplasms / surgery. Sphenoid Sinus / surgery. Third Ventricle / surgery
  • [MeSH-minor] Adult. Decompression, Surgical / methods. Humans. Male. Neoplasm, Residual / diagnosis. Neoplasm, Residual / surgery. Postoperative Complications / diagnosis. Reoperation

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20376745.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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41. Kim JK, Yoo KS, Moon JH, Park KH, Chung YW, Kim KO, Park CH, Hahn T, Park SH, Kim JH, Jeon JY, Kim MJ, Min KS, Park CK: Gallbladder lymphangioma: a case report and review of the literature. World J Gastroenterol; 2007 Jan 14;13(2):320-3
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  • Lymphangiomas are rare, benign tumors of the lymphatic system, usually present in children aged 5 years and younger.
  • We experienced a case of a 60-year-old man diagnosed with a cystic lymphangioma of the gallbladder, which was successfully resected without any complication.
  • Magnetic resonance imaging and magnetic resonance cholangiopancreatography were very helpful for the diagnosis of the cystic lesion around the gallbladder as were ultrasonography and computed tomography scan.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Lymphangioma / diagnosis

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  • (PMID = 17226918.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 12
  • [Other-IDs] NLM/ PMC4065967
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42. Ueno T, Sasaki K, Yoshida S, Kajitani N, Satsuka A, Nakamura H, Sakai H: Molecular mechanisms of hyperplasia induction by human papillomavirus E7. Oncogene; 2006 Jul 13;25(30):4155-64
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  • Infections of human papillomavirus (HPV) induce a variety of benign tumors, such as warts and condylomas.
  • During the process of aberrant cell proliferation, genetic mutations are accumulated in the cells, from which malignant tumor cells arise.

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  • (PMID = 16501608.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / E7 protein, Human papillomavirus type 18; 0 / Oncogene Proteins, Viral; 0 / Retinoblastoma Protein
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43. Pui MH, Wang Y: Diffusion and magnetization transfer MRI of brain infarct, infection, and tumor in children. Clin Imaging; 2005 May-Jun;29(3):162-71
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  • [Title] Diffusion and magnetization transfer MRI of brain infarct, infection, and tumor in children.
  • The purpose of this study was to determine the efficacy of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) in the differential diagnosis of brain infarct, infection, hamartoma, and tumor in 106 children.
  • There was an inverse relationship between ADC and MTR in subacute/chronic infarct, infection, hamartoma, arachnoid cyst, and tumor relative to normal brain parenchyma.
  • DWI and MTI had a complementary role in the differential diagnosis of acute infarct from infection with lower MTR, from hamartoma with higher ADC, and from low-grade gliomas and benign tumors that had higher ADCs and lower MTRs.
  • ADCs increased and MTRs decreased with the duration of infarct and lower tumor grade.
  • [MeSH-major] Brain / pathology. Brain Neoplasms / diagnosis. Central Nervous System Infections / diagnosis. Cerebral Infarction / diagnosis. Diffusion Magnetic Resonance Imaging. Image Processing, Computer-Assisted
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Infant, Newborn. Male. Sensitivity and Specificity

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  • (PMID = 15855060.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Schäfer H, Baldus SE, Hölscher AH: Giant adenomas of the rectum: complete resection by transanal endoscopic microsurgery (TEM). Int J Colorectal Dis; 2006 Sep;21(6):533-7
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  • Transanal endoscopic microsurgery (TEM) offers an alternative operation method to low-anterior rectum resection in this potentially benign tumor situation.
  • A total of 33 patients met the criteria and were analyzed for postoperative complications, histology, and incidence of occult adenocarcinoma; residual tumor status; and tumor recurrence.
  • The residual adenoma status was 18% (n=6), especially in patients with tumors sizes more than 30 cm2.
  • In case of adenoma recurrence (n=4, 12%), a conventional transanal excision (Parks) was applicable, as these tumors were mostly located within the suture-line region of the lower rectum.
  • In case of advanced tumors (1xpT2, 1xpT3), anterior rectum resection was carried out, whereas for the early tumors (2xpT1 low risk, 1x1 pTis), no further therapy was added.
  • CONCLUSION: TEM is an alternative method for the resection of large benign rectal tumors located in the mid- and upper third of the rectum.
  • [MeSH-major] Adenoma / surgery. Colonoscopy / methods. Microsurgery. Rectal Neoplasms / surgery

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  • (PMID = 16133003.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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45. Ahmed S, Burney I, Sawhney S, Al-Moundhri MS: Gastric Adenocarcinoma in Association with Tuberous Sclerosis: Case report. Sultan Qaboos Univ Med J; 2009 Apr;9(1):75-8
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  • Tuberous sclerosis is an autosomal dominant disorder which presents with a constellation of signs including benign tumours in the brain and in other vital organs such as the kidneys, heart, eyes, lungs, and skin.
  • A combination of symptoms may include seizures, developmental delay, behavioural problems, skin abnormalities, and lung and kidney disease.
  • These proteins act as tumour growth suppressor agents that regulate cell proliferation and differentiation.

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  • [Cites] J Korean Med Sci. 2000 Aug;15(4):467-70 [10983700.001]
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  • (PMID = 21509279.001).
  • [ISSN] 2075-051X
  • [Journal-full-title] Sultan Qaboos University medical journal
  • [ISO-abbreviation] Sultan Qaboos Univ Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3074756
  • [Keywords] NOTNLM ; Case report / Gastric cancer / Hamartoma / Lymphangiomyomatosis / Mucinous adenocarcinoma / Oman / Tuberous sclerosis
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46. Hasturk A, Tun K, Guvenc Y, Kaptanoglu E: Cranial ossifying fibroma causing visual disorder. J Craniofac Surg; 2010 May;21(3):768-70
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  • [Title] Cranial ossifying fibroma causing visual disorder.
  • Fibrous lesions of the head and the maxillofacial region are generally slow-developing benign tumors that may aggressively take course in clinical terms.
  • Difficulties in the diagnosis, classification, and treatment make this entity complex for several years.
  • These tumors are frequently seen among children and young adults.
  • The maxilla and the mandibula are the 2 most common sites that the tumor originates.
  • Accompanied by literature findings, it has been underlined that, as well as with the pathologic criteria, clinical features and radiologic images should be evaluated together for a specific diagnosis in fibrous lesions.
  • [MeSH-major] Fibroma, Ossifying / complications. Skull Neoplasms / complications. Vision Disorders / etiology
  • [MeSH-minor] Craniotomy. Decompression, Surgical. Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20485044.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Bornemann A, Koitschev A: A 57-year-old female with a benign tumor in the ethmoid sinus. Brain Pathol; 2006 Oct;16(4):335-6
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  • [Title] A 57-year-old female with a benign tumor in the ethmoid sinus.
  • [MeSH-major] Ethmoid Sinus / pathology. Neurocytoma / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Mucocele / pathology. Tomography, X-Ray Computed

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  • (PMID = 17107604.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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48. Chang W, Oiseth SJ, Orentlicher R, Agarwal G, Yahr LJ, Cayten CG: Bilateral sclerosing stromal tumor of the ovaries in a premenarchal girl. Gynecol Oncol; 2006 May;101(2):342-5
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  • [Title] Bilateral sclerosing stromal tumor of the ovaries in a premenarchal girl.
  • BACKGROUND: Sclerosing stromal tumor of the ovary is a rare benign neoplasm that is usually unilateral in menstruating women with a mean age of 27.
  • CASE: An 11-year-old girl presented with asymptomatic bilateral sclerosing stromal tumor of the ovaries prior to menarche.
  • CONCLUSION: We herein report a unique case of bilateral sclerosing stromal tumor of the ovaries arising in a premenarchal girl.
  • [MeSH-major] Ovarian Neoplasms / pathology

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  • (PMID = 16403568.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Kwon H, Kim HY, Jung SN, Sohn WI, Yoo G: Extraskeletal chondroma in the auricle. J Craniofac Surg; 2010 Nov;21(6):1990-1
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  • Extraskeletal chondroma is a rare benign tumor that develops in soft tissues, and histologically, it is a lobulated nodule surrounded by a fibrous capsule, and the inside consists of mature cartilage cells and diffuse hyalinized matrix.
  • [MeSH-major] Chondroma / diagnosis. Ear Auricle / pathology. Ear Neoplasms / diagnosis

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  • (PMID = 21119479.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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50. Telem DA, Nguyen SQ, Chin EH, Weber K, Divino CM: Laparoscopic resection of giant adrenal cavernous hemangioma. JSLS; 2009 Apr-Jun;13(2):260-2
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  • BACKGROUND: Large adrenal tumors were initially believed to be a relative contraindication to laparoscopic adrenalectomy.
  • METHODS: Here we discuss the case of a 42-year-old female with a 12-cm adrenal mass.
  • RESULTS: The patient underwent successful laparoscopic resection, and pathology revealed a cavernous hemangioma, a rare benign tumor of the adrenal gland.

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  • (PMID = 19660229.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3015926
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51. Kutay V, Tuncer M, Harman M, Ekim H, Yakut C: Intracardiac extension of intravenous leiomyoma. Tex Heart Inst J; 2005;32(2):232-4
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  • Intravenous leiomyoma with intracaval and intracardiac extension is a rare benign neoplasm affecting women.
  • The correct diagnosis was made intraoperatively, after resection of the intracardiac extension of the tumor, which was 28 cm in length.
  • At the 2nd stage of the operation, a right common iliac venotomy enabled the removal of all residual tumor from the inferior vena cava.

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  • (PMID = 16107124.001).
  • [ISSN] 0730-2347
  • [Journal-full-title] Texas Heart Institute journal
  • [ISO-abbreviation] Tex Heart Inst J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1163482
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52. Martínez De Pablo MI, Iranzo P, Mascaró JM, Llambrich A, Baradad M, Herrero C: Paraneoplastic pemphigus associated with non-Hodgkin B-cell lymphoma and good response to prednisone. Acta Derm Venereol; 2005;85(3):233-5
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  • [Title] Paraneoplastic pemphigus associated with non-Hodgkin B-cell lymphoma and good response to prednisone.
  • Paraneoplastic pemphigus is a life-threatening autoimmune bullous disease associated with neoplasia, generally of lymphoid origin.
  • These cases were generally associated with benign neoplasms.
  • We report here the case of a patient with paraneoplastic pemphigus associated with non-Hodgkin B-cell lymphoma who had a surprisingly good response to systemic corticosteroids and remains free of lesions more than 3 years later despite progression of her neoplasm.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Paraneoplastic Syndromes / diagnosis. Pemphigus / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Drug Administration Schedule. Female. Glucocorticoids / administration & dosage. Humans. Oral Ulcer / pathology. Prednisone / administration & dosage

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  • (PMID = 16040408.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Glucocorticoids; VB0R961HZT / Prednisone
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53. Perrini P, Caniglia M, Pieroni M, Castagna M, Parenti GF: Malignant transformation of intramedullary melanocytoma: case report. Neurosurgery; 2010 Sep;67(3):E867-9; discussion E869
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  • OBJECTIVE: Meningeal melanocytomas are low-grade primary melanocytic tumors with benign histological features and a favorable clinical prognosis.
  • Two years later, the tumor recurred locally, and the patient underwent additional surgery to remove the intramedullary mass.
  • The histological findings of the tumor were consistent with an intramedullary malignant melanoma.
  • CONCLUSION: The malignant transformation of melanocytic tumors of the central nervous system may occur years after surgical treatment, and its incidence remains unknown.
  • Emphasis should be placed on the importance of careful and continued follow-up monitoring of the tumor.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Melanoma / pathology. Meningeal Neoplasms / pathology. Nevus, Pigmented / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 20657325.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Kawamura K, Komohara Y, Takaishi K, Katabuchi H, Takeya M: Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors. Pathol Int; 2009 May;59(5):300-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors.
  • Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype.
  • They contribute to tumor growth, invasion, and metastasis by producing various mediators.
  • Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors.
  • The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors.
  • The method focused on immunostaining of paraffin-embedded tumor samples.
  • Almost all macrophages infiltrating tumor tissues expressed CD163 and CD204, indicating the phenotypic shift toward M2 macrophage.
  • The numbers of CD68-positive macrophages as well as of CD163- and CD204-positive macrophages in borderline and malignant tumors were significantly higher than in benign tumors.
  • CSF-1 expression in malignant tumor cells was significantly higher than that in benign tumor cells and correlated with histological malignancy.
  • These results suggest that CSF-1 derived from tumor tissues induces macrophages to shift toward the M2 phenotype, which is considered to promote tumor growth.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / immunology. Cystadenocarcinoma, Serous / immunology. Macrophage Colony-Stimulating Factor / biosynthesis. Macrophages / immunology. Ovarian Neoplasms / immunology
  • [MeSH-minor] Adult. Aged. Antigens, CD / immunology. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / immunology. Antigens, Differentiation, Myelomonocytic / metabolism. Cell Differentiation / immunology. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness / immunology. Phenotype. Receptors, Cell Surface / immunology. Receptors, Cell Surface / metabolism. Scavenger Receptors, Class A / immunology. Scavenger Receptors, Class A / metabolism

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  • (PMID = 19432671.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD163 antigen; 0 / MSR1 protein, human; 0 / Receptors, Cell Surface; 0 / Scavenger Receptors, Class A; 81627-83-0 / Macrophage Colony-Stimulating Factor
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55. Ko JM, Jung JI, Park SH, Lee KY, Chung MH, Ahn MI, Kim KJ, Choi YW, Hahn ST: Benign tumors of the tracheobronchial tree: CT-pathologic correlation. AJR Am J Roentgenol; 2006 May;186(5):1304-13
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  • [Title] Benign tumors of the tracheobronchial tree: CT-pathologic correlation.
  • OBJECTIVE: The purpose of this essay is to illustrate the CT findings of variable benign tumors of the tracheobronchial tree and to correlate the CT and pathologic findings in 17 patients.
  • CONCLUSION: The tracheal tumors were eccentric, well-defined, polypoid masses in all cases.
  • The endobronchial tumors were masses confined within the bronchus in all cases, and atelectasis or pneumonia of the distal parenchyma was frequently associated.
  • The other benign tumors were low-attenuating, soft-tissue-density masses without characteristic findings on CT scans.
  • [MeSH-major] Bronchial Neoplasms / pathology. Bronchial Neoplasms / radiography. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / radiography. Tomography, X-Ray Computed. Tracheal Neoplasms / pathology. Tracheal Neoplasms / radiography

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  • (PMID = 16632723.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Meccariello R, Damiano I, Pelosio L, Rizzo GM, Ansalone M, D'Aniello F: [Biliodigestive anastomosis: case series and technical notes]. Minerva Chir; 2006 Feb;61(1):31-7
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  • [Transliterated title] Anastomosi bilio-digestive. Casistica e note di tecnica.
  • Thirty biliodigestive anastomose have been performed both for neoplastic disease and for benign lesions.
  • RESULTS: The biliodigestive anastomosis has been performed with the Blumgart's technique both for benign and malignant tumors.

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  • (PMID = 16568020.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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57. Sharma U, Danishad KK, Seenu V, Jagannathan NR: Longitudinal study of the assessment by MRI and diffusion-weighted imaging of tumor response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. NMR Biomed; 2009 Jan;22(1):104-13
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  • [Title] Longitudinal study of the assessment by MRI and diffusion-weighted imaging of tumor response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy.
  • Measurements of tumor apparent diffusion coefficient (ADC), volume and diameter in assessing the response of patients with locally advanced breast cancer (LABC) (n = 56) undergoing neoadjuvant chemotherapy (NACT) at four time periods (before treatment and after three cycles of NACT) were carried out at 1.5 T using diffusion-weighted imaging (DWI) and MRI.
  • Ten benign tumors and 15 controls were also investigated.
  • The MR tumor response was compared with the clinical response.
  • Mean ADC before treatment of malignant breast tissue was significantly lower than that of controls, disease-free contralateral tissue of the patients, and benign lesions, and gradually increased during the course of NACT.
  • Analysis of the percentage change in ADC, volume and diameter after each cycle of NACT between clinical responders and non-responders showed that the change in ADC after the first cycle was statistically significant compared with volume and diameter, indicating its potential in assessing early response.
  • After the third cycle, the sensitivity for differentiating responders from non-responders was 89% for volume and diameter and 68% for ADC, and the respective specificities were 50%, 70% and 100%.
  • A cut-off value of ADC was also calculated using receiver operator characteristics analysis to discriminate between normal, benign and malignant breast tissue.
  • Similarly, a cut-off value for ADC, volume and diameter was obtained after the second and third cycles of NACT to predict tumor response.
  • The results show that ADC is more useful for predicting early tumor response to NACT than morphological variables, suggesting its potential in effective treatment management.
  • [MeSH-major] Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Diffusion Magnetic Resonance Imaging. Neoadjuvant Therapy

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  • (PMID = 18384182.001).
  • [ISSN] 0952-3480
  • [Journal-full-title] NMR in biomedicine
  • [ISO-abbreviation] NMR Biomed
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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58. Pais SA, Attasaranya S, Leblanc JK, Sherman S, Schmidt CM, DeWitt J: Role of endoscopic ultrasound in the diagnosis of intraductal papillary mucinous neoplasms: correlation with surgical histopathology. Clin Gastroenterol Hepatol; 2007 Apr;5(4):489-95
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  • [Title] Role of endoscopic ultrasound in the diagnosis of intraductal papillary mucinous neoplasms: correlation with surgical histopathology.
  • BACKGROUND & AIMS: Intraductal papillary mucinous neoplasms (IPMNs) are precancerous tumors characterized by dilation of the main pancreatic duct, its side branches, or both.
  • The purpose of this study was to evaluate the role of endoscopic ultrasound (EUS) in differentiating benign and malignant IPMNs.
  • Malignancy was defined as the presence of invasive carcinoma; all other neoplasms were considered benign.
  • RESULTS: Seventy-four patients (38 male; mean age, 65 years) with 21 (28%) malignant and 53 (72%) benign IPMNs were identified.
  • Compared with benign tumors, patients with malignant IPMNs were more likely to be older (P = .011), present with jaundice (P = .03) or weight loss (P = .03), and have EUS features of a dilated main pancreatic duct (P = .0001), solid lesion (P = .0001), pancreatic ductal filling defects (P = .03), or thickened septa within any cyst (P = .02).
  • The sensitivity, specificity, and accuracy of EUS-FNA for the diagnosis of malignancy were 75% (95% confidence interval [CI], 53%-89%), 91% (95% CI, 79%-97%), and 86% (95% CI, 76%-93%), respectively.
  • CONCLUSIONS: Older age, jaundice and weight loss, and EUS features of a solid lesion, dilated main pancreatic duct, ductal filling defects, and thickened septa are predictive of malignancy in patients with IPMNs.
  • EUS-FNA cytology is helpful, but cyst fluid CEA and CA 19-9 are of limited value to differentiate malignant from benign IPMNs.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / ultrasonography. Endosonography / methods. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography

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  • (PMID = 17350894.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Kobayashi K, Fukata S, Miyauchi A: Diagnosis of follicular carcinoma of the thyroid: role of sonography in preoperative diagnosis of follicular nodules. J Med Ultrason (2001); 2005 Dec;32(4):153-8
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  • [Title] Diagnosis of follicular carcinoma of the thyroid: role of sonography in preoperative diagnosis of follicular nodules.
  • Nine hundred and ten consecutive patients with follicular nodules were pathologically classified as having follicular carcinoma (109 patients) or benign tumor (811 patients).
  • Benign tumors included follicular adenoma (237 patients) and adenomatous thyroid nodules (574 patients).
  • A case-control study was performed for follicular carcinomas and benign tumors.
  • "Thyroglobulin 1000 ng/ml≦", "cytology class 3≦", and a "solid pattern", "low-echoic level of internal echo", and "jagged borders" of follicular carcinomas were found to be significantly higher than those of benign tumors.
  • The sensitivities of a solid pattern (79.8%) and a low-echoic level (75.2%) were found to be relatively higher than those of other features and findings.

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  • (PMID = 27277482.001).
  • [ISSN] 1346-4523
  • [Journal-full-title] Journal of medical ultrasonics (2001)
  • [ISO-abbreviation] J Med Ultrason (2001)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; cytology / follicular carcinoma / sonography / thyroglobulin / thyroid
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60. Pandya KA, Radke F: Benign skin lesions: lipomas, epidermal inclusion cysts, muscle and nerve biopsies. Surg Clin North Am; 2009 Jun;89(3):677-87
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  • [Title] Benign skin lesions: lipomas, epidermal inclusion cysts, muscle and nerve biopsies.
  • Lipomas are benign skin tumors composed of mature fat cells and are the most common subcutaneous tumors.
  • The diagnosis, pathology, and treatment of benign tumors, and other commonly associated tumors that may require a more substantial workup and operative intervention, are discussed.
  • Muscle and nerve biopsies are used for the diagnosis of a variety of medical problems.
  • Although the procedures are straightforward, there are important technical issues to assist in getting the best specimen to avoid confounding disease diagnosis.
  • [MeSH-major] Biopsy / methods. Cysts / pathology. Lipoma / pathology. Muscle, Skeletal / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 19465204.001).
  • [ISSN] 1558-3171
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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61. Tincani AJ, Araújo PP, DelNegro A, Altemani A, Martins AS: Childhood maxillary myxoma: case report and review of management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):e5-8
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  • Myxomas are benign neoplasms of uncertain origin and etiology.
  • More recently, in 1995, Takahashi et al., through extensive research confirmed the fibroblastic and histiocytic origin of the tumor.
  • [MeSH-major] Facial Asymmetry / surgery. Maxillary Neoplasms / surgery. Myxoma / surgery

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  • (PMID = 17764985.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Ceylan A, Celenk F, Poyraz A, Uslu S: Pleomorphic adenoma of the nasal columella. Pathol Res Pract; 2008;204(4):273-6
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  • Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands.
  • Irrespective of the site where the lesion originates, its preferred treatment should be surgery.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local. Neoplasm Seeding. Nose Neoplasms / pathology

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  • (PMID = 18295980.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Akcali Y, Karahan OI, Kahriman G, Ceyran H, Balkanli S: Angiomyolipoma with cavoatrial extension. Eur Urol; 2006 Sep;50(3):605-6
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  • Pathologic evaluation revealed a tumor consisting of mature adipose tissue, smooth muscle and vessels consistent with angiomyolipoma.
  • Our case reminds us of the rare possibility that angiomyolipoma, which is classified as a benign tumor, may invade the inferior vena cava or right atrium.
  • [MeSH-major] Angiomyolipoma / diagnosis. Heart Atria / pathology. Heart Neoplasms / diagnosis

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  • (PMID = 16828222.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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64. Kamat G, Yelikar B, Shettar S, Karigoudar MH: Pigmented trichoblastoma with sebaceous hyperplasia. Indian J Dermatol Venereol Leprol; 2009 Sep-Oct;75(5):506-8
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  • Trichoblastoma is a rare benign trichogenic tumour with epithelial and mesenchymal components recapitulating the germinal hair bulb and associated mesenchyme.
  • Microscopy of tumour revealed nodular tumour spanning the entire dermis with collection of mesenchymal cells resembling follicular papilla.
  • There is a need for differentiation of this tumor which is benign, from other pigmented tumors having basaloid arrangement of cells such as basal cell carcinoma.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Humans. Hyperplasia. Male. Middle Aged. Skin Neoplasms / complications. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Pigmentation

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  • (PMID = 19736433.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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65. Wang Q, Wang S, Zhou S, Lu Y: [Clinical analysis of the primary nasal septum mass in 253 cases]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Jan;23(2):60-2
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  • CONCLUSION: If the diagnosis was confirmed, the effect of the surgical treatment for the nasal septum benign tumor is satisfactory.
  • Follow-up should be done in cases with malignant tendency and malignant tumors.
  • [MeSH-major] Nasal Septum / pathology. Nose Neoplasms

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  • (PMID = 19452708.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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66. Ramana RK, Darki A, Havens M, Wojcik E, Brylka D, Singh MM, Leya F: Lipotamous cardiac disorders: two unsual cases and a review of the literature. J Invasive Cardiol; 2009 Apr;21(4):E65-9
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  • Tumors involving the heart and surrounding cardiac structures may be benign or malignant and can be classified as primary versus secondary in etiology.
  • Primary cardiac tumors are rare lesions and the vast majority of these are benign neoplasms.
  • [MeSH-major] Cardiomyopathy, Hypertrophic / diagnosis. Heart Diseases / diagnosis. Heart Neoplasms / diagnosis. Lipomatosis / diagnosis

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  • (PMID = 19342764.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
  • [Number-of-references] 36
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67. Ang WM, Yates P, Robbins P, Wood D: Recurrent benign solitary intraosseous schwannoma of the tibia. Orthopedics; 2008 Feb;31(2):176
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  • [Title] Recurrent benign solitary intraosseous schwannoma of the tibia.
  • Schwannomas (neurilemmomas) are benign neoplasms composed of well-differentiated Schwann cells and are usually found in the soft tissues.
  • The occurrence of schwannomas in bone is rare, accounting for less than 0.2% of primary bone tumors.
  • We report the first case of a recurrent benign solitary intraosseous schwannoma of the tibia, and detail the clinical, radiological and histological findings.
  • [MeSH-major] Bone Neoplasms / radiography. Bone Neoplasms / surgery. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / surgery. Neurilemmoma / radiography. Neurilemmoma / surgery. Tibia / surgery

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  • (PMID = 19292192.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Kim HK, Choi YH, Cho YH, Sohn YS, Kim HJ: Intercostal neuralgia caused by a parosteal lipoma of the rib. Ann Thorac Surg; 2006 May;81(5):1901-3
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  • Parosteal lipoma is an extremely rare benign tumor that is composed mainly of mature adipose tissue, and it has an intimate relationship to the underlying periosteal bone.
  • Although parosteal lipoma is asymptomatic, motor and sensory function deficits have been reported that were caused by the tumor compressing the neuromuscular bundles in the proximal forearm and the sciatic nerve.
  • [MeSH-major] Bone Neoplasms / complications. Chest Pain / etiology. Lipoma / complications. Periosteum / pathology. Ribs

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  • (PMID = 16631705.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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69. Theodorou DJ, Theodorou SJ, Sartoris DJ: An imaging overview of primary tumors of the spine: Part 1. Benign tumors. Clin Imaging; 2008 May-Jun;32(3):196-203
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  • [Title] An imaging overview of primary tumors of the spine: Part 1. Benign tumors.
  • Primary benign tumors of the spine are uncommon, with intriguing clinical and imaging manifestations.
  • Presentation of a solitary lesion of the spine can pose a difficult diagnostic dilemma.
  • We revisit the imaging characteristics of benign spinal tumors, realizing that a concise and handy overview of disease findings can prove useful for radiologists and clinicians engaged in routine practice.
  • This review may serve as a comprehensive imaging tool summarizing key manifestations of disease.
  • A broad range of benign spinal tumors is illustrated, with emphasis on the imaging features that may allow prospective diagnosis in most cases.
  • [MeSH-major] Diagnostic Imaging / methods. Image Enhancement. Spinal Neoplasms / pathology. Spinal Neoplasms / radiography
  • [MeSH-minor] Adult. Contrast Media / pharmacology. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Staging. Sensitivity and Specificity. Spinal Diseases / pathology. Spinal Diseases / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 18502347.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 17
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70. Dallaudiere B, Benayoun Y, Boncoeur-Martel M, Robert P, Adenis J, Maubon A: [Imaging features of cavernous hemangiomas of the orbit]. J Radiol; 2009 Sep;90(9 Pt 1):1039-45
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  • Cavernous hemangioma is the most frequent benign tumor of the orbit.
  • The clinical presentation is that of a slowly progressive intra-orbital mass with variable degree of exophthalmos.
  • CT typically demonstrates the presence of a well defined oval or rounded shaped mass but MRI provides superior evaluation of the orbit.
  • The tumor is intra-conal in 80% of cases and usually shows T1W hypo-isointensity, T2W hyperintensity and heterogeneous contrast enhancement that becomes more homogeneous on delayed imaging (5 minutes).
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Orbital Neoplasms / diagnosis

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  • (PMID = 19752807.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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71. Khandekar MM, Kavatkar AN, Patankar SA, Bagwan IB, Puranik SC, Deshmukh SD: FNAC of salivary gland lesions with histopathological correlation. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):246-8
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  • To evaluate utility of FNAC in salivary gland lesions.Back ground: Salivary gland lesions form about 2-6.5% of all head and neck neoplasms in adults.
  • They are easily accessible for FNAC (Fine Needle Aspiration Cytology) and risks of fistula formation or tumour implantation are low compared surgical biopsy.
  • Also, cytology can provide a distinction between asalivary and non salivary lesion, benign and malignant lesions so also specific and non specific inflammation.
  • RESULTS: 80% of the lesions were neoplastic (61% benign, 31% malignant) and 20% were neoplastic.
  • Pleomorphic adenoma was the most frequent benign neoplasm while mucoepidermoid carcinoma was the most frequent malignant lesion.
  • Among the non neoplastic lesions, the maximum number of cases were of chronic sialadentis.
  • In the present study, FNAC has a sensitivity of 94.54% and specificity of 80.95% for neoplastic lesions.
  • CONCLUSIONS: FNAC was found to be a useful diagnostic tool in the evaluation of salivary gland lesions because of its simplicity, excellent patient compliance and rapid diagnosis.

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  • (PMID = 23120304.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450424
  • [Keywords] NOTNLM ; FNAC / Salivary Gland / Salivary Gland Tumours
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72. Belizon A, Balik E, Horst PK, Shantha Kumara HM, Nasar A, Whelan RL: Platelet-derived growth factor (subtype BB) is elevated in patients with colorectal carcinoma. Dis Colon Rectum; 2009 Jun;52(6):1166-71
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  • PURPOSE: Platelet-derived growth factor-BB plays a role in the development of vascular and lymphatic vessels in tumors.
  • Preoperative colorectal cancer platelet-derived growth factor-BB levels were higher (1,771.1 pg/ml; confidence intervals, 1,429-2,065) than in the benign neoplasm group (1083 pg/ml; confidence intervals, 933-1,192, P < 0.001).
  • In patients with colorectal cancer, a direct relationship was noted between platelet-derived growth factor-BB levels and disease severity.
  • CONCLUSION: Platelet-derived growth factor-BB levels were greater in patients with colorectal cancer (vs. patients with adenoma) and rose with increasing disease severity.
  • [MeSH-major] Adenoma / blood. Colorectal Neoplasms / blood. Platelet-Derived Growth Factor / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / blood. Chi-Square Distribution. Enzyme-Linked Immunosorbent Assay. Female. Humans. Logistic Models. Male. Proto-Oncogene Proteins c-sis. Statistics, Nonparametric

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  • (PMID = 19581863.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / platelet-derived growth factor BB
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73. Lin Y, Qiu JH, Qiao L, He LS, Zha DJ: Le Fort I osteotomy for extensive juvenile nasopharyngeal angiofibroma: a retrospective study. Adv Ther; 2008 Oct;25(10):1057-64
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  • INTRODUCTION: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, nonencapsulated, benign neoplasm typically diagnosed in adolescent boys.
  • The optimal surgical procedure should allow maximal exposure of the tumor for complete excision with minimum morbidity.
  • METHODS: We retrospectively studied patients who had undergone JNA resection via the Le Fort I osteotomy approach from July 2000 to September 2007, considering tumor location and size, complications, and tumor recurrence associated with the surgical approach.
  • There were no cases of tumor recurrence that could be attributed to the procedure.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery. Osteotomy, Le Fort / methods

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  • (PMID = 18836867.001).
  • [ISSN] 0741-238X
  • [Journal-full-title] Advances in therapy
  • [ISO-abbreviation] Adv Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Boozari B, Lotz J, Galanski M, Gebel M: [Diagnostic imaging of liver tumours. Current status]. Internist (Berl); 2007 Jan;48(1):8, 10-2, 14-6, 18-20
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  • [Title] [Diagnostic imaging of liver tumours. Current status].
  • These methods have comparable sensitivity and specificity in differentiating a liver lesion as "benign" or "malignant".
  • For benign lesions, CEUS is the recommended method of the choice.
  • If a benign tumor remains unclear, then a needle biopsy is recommended.
  • In the case of a malignant tumor, it is necessary to use a second imaging technique besides CEUS.
  • In addition to the detection and characterization of a liver tumor, CT and MRI provide information on the extrahepatic spread of a tumor, particularly into the lung or retroperitoneum.
  • [MeSH-major] Image Enhancement. Image Processing, Computer-Assisted. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging. Tomography, Spiral Computed. Ultrasonography
  • [MeSH-minor] Contrast Media / administration & dosage. Diagnosis, Differential. Humans. Liver Diseases / diagnosis. Sensitivity and Specificity

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  • (PMID = 17216509.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 56
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75. Fine SW, Epstein JI: Inverted urothelial papillomas with foamy or vacuolated cytoplasm. Hum Pathol; 2006 Dec;37(12):1577-82
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  • Inverted papillomas of the bladder are uncommon benign neoplasms characterized by endophytic growth of urothelial cells as anastomosing cords, displaying minimal cytologic atypia.
  • The diagnostic dilemma encountered in these cases of inverted papilloma with foamy or vacuolated cytoplasm warrants their distinction from other benign and malignant urothelial lesions with inverted growth and/or clear cell features.
  • [MeSH-major] Cytoplasm / ultrastructure. Papilloma, Inverted / ultrastructure. Urinary Bladder Neoplasms / ultrastructure. Urothelium / ultrastructure

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  • (PMID = 16949916.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Abd el-All HS: Breast spindle cell tumours: about eight cases. Diagn Pathol; 2006;1:13
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  • [Title] Breast spindle cell tumours: about eight cases.
  • BACKGROUND: Breast spindle cell tumours (BSCTs), although rare, represent a heterogeneous group with different treatment modalities.
  • RESULTS: FNAC defined the tumors as benign (n = 4), suspicious (n = 2) and malignant (n = 3), based on the cytopathological criteria of malignancy.
  • Following wide excision biopsy, the tumors were reclassified into benign (n = 5) and malignant (n = 3).
  • In the benign group, the diagnosis was raised histologically and confirmed by IHC for 3 cases (one spindle cell lipoma, one myofibroblastoma and one leiomyoma).
  • For the remaining two cases, the diagnosis was set up after IHC (one fibromatosis and one spindle cell variant of adenomyoepithelioma).
  • In the malignant group, a leiomyosarcoma was diagnosed histologically, while IHC was crucial to set up the diagnosis of one case of spindle cell carcinoma and one malignant myoepithelioma.
  • The latter technique differentiate benign from malignant BSCTs and is able in 50% of the cases to set up the definite diagnosis.
  • IHC is of value to define the nature of different benign lesions and is mandatory in the malignant ones for optimal treatment.

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  • (PMID = 16859566.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1557590
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77. Buckner JC, Brown PD, O'Neill BP, Meyer FB, Wetmore CJ, Uhm JH: Central nervous system tumors. Mayo Clin Proc; 2007 Oct;82(10):1271-86
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  • [Title] Central nervous system tumors.
  • Central nervous system tumors are relatively common in the United States, with more than 40,000 cases annually.
  • Although more than half of these tumors are benign, they can cause substantial morbidity.
  • Malignant primary brain tumors are the leading cause of death from solid tumors in children and the third leading cause of death from cancer in adolescents and adults aged 15 to 34 years.
  • Whereas magnetic resonance imaging helps define the anatomic extent of tumor, biopsy is often required to confirm the diagnosis.
  • Treatment depends on the histologic diagnosis.
  • Benign tumors are usually curable with surgical resection or radiation therapy including stereotactic radiation; however, most patients with malignant brain tumors benefit from chemotherapy either at the time of initial diagnosis or at tumor recurrence.
  • Metastases to the brain remain a frequent and morbid complication of solid tumors but are frequently controlled with surgery or radiation therapy.
  • Unfortunately, the mortality rate from malignant brain tumors remains high, despite initial disease control.
  • This article provides an overview of current diagnostic and treatment approaches for patients with primary and metastatic brain tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Glioma / diagnosis. Glioma / therapy. Humans

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  • (PMID = 17908533.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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78. Rochdi Y, Raji A, Elhattab Y, Nouri H, Bouchoua F, Narjisse Y, Ait Mbark B: [Tuberculosis of the parotid gland]. Rev Laryngol Otol Rhinol (Bord); 2007;128(1-2):121-3
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  • [Transliterated title] La tuberculose de la glande parotide.
  • INTRODUCTION: Tuberculosis of the parotid gland is a rare entity, and the preoperative diagnosis is difficult as the symptomatology is nonspecific.
  • OBSERVATION: We report a case of a three year old child without a history of tuberculosis, who presented with an isolated parotid mass for three months.
  • Physical examination and ultrasonography suggested a benign tumour.
  • The patient underwent superficial parotidectomy with preservation of the facial nerve, and the diagnosis of tuberculosis was made by histopathological study of the specimen.
  • DISCUSSION-CONCLUSION: This case highlights that tuberculosis of the parotid gland must be kept in mind in the differential diagnosis of parotid swellings, in order to avoid parotidectomy, in a medically treatable condition.

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  • (PMID = 17633682.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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79. Glenn LW: Innovations in neuroimaging of skull base pathology. Otolaryngol Clin North Am; 2005 Aug;38(4):613-29
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  • CT angiography can assess vascular structures noninvasively, and CT perfusion can help differentiate between malignant and benign tumors.
  • PET scanning and CT/PET scanning will increasingly become a mainstay of head and neck tumor imaging for initial staging, monitoring response to therapy,and detecting recurrent disease or metastases.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Skull Base Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 16005721.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 16
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80. Boyce S, Khor YP: A colonic submucosal lipoma presenting with recurrent intestinal obstruction attacks. BMJ Case Rep; 2009;2009
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  • Colonic submucosal lipomas are rare benign tumours of the colon, which may be discovered incidentally at colonoscopy, through imaging such as CT or at autopsy.
  • These tumours can cause complications such as bleeding, intussusception and bowel obstruction.
  • We describe the case of a patient in whom a small submucosal lipoma was identified at the time of colonoscopy and who did not receive follow-up treatment.

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  • (PMID = 21686420.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028313
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81. Ogbureke KU, Nashed MN, Ayoub AF: Huge peripheral osteoma of the mandible: a case report and review of the literature. Pathol Res Pract; 2007;203(3):185-8
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  • Osteomas are rare benign tumors of bone commonly occurring in the maxillofacial skeleton.
  • Here, we report a case of a huge solitary peripheral osteoma of the lingual posterior mandible in a 50-year-old woman who was otherwise in good health.
  • Histological examination confirmed the clinical impression of a peripheral osteoma.
  • [MeSH-major] Mandibular Neoplasms / pathology. Osteoma / pathology

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  • (PMID = 17307307.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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82. Bastos Netto JM, Esteves TC, Mattos Rde C, Tibiriçá SH, Costa SM, Vieira LJ: Metanephric adenoma: a rare differential diagnosis of renal tumor in children. J Pediatr Urol; 2007 Aug;3(4):340-1
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  • [Title] Metanephric adenoma: a rare differential diagnosis of renal tumor in children.
  • Metanephric adenoma is an extremely rare tumor of the kidney.
  • The clinical and anatomic characteristics are not yet well defined, but it is currently considered to be a benign tumor with a good prognosis, although recently two metastatic cases have been reported.
  • The morphological characteristics are similar to those of Wilms' tumor, suggesting a common embryological precursor.
  • We present here the youngest girl yet to be reported with a diagnosis of metanephric adenoma.

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  • (PMID = 18947770.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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83. Rushing EJ, Cooper PB, Quezado M, Begnami M, Crespo A, Smirniotopoulos JG, Ecklund J, Olsen C, Santi M: Subependymoma revisited: clinicopathological evaluation of 83 cases. J Neurooncol; 2007 Dec;85(3):297-305
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  • OBJECT: Subependymomas are rare ependymal neoplasms.
  • To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported.
  • Tumors arose in the posterior fossa (n = 43), lateral ventricles (n = 37), spinal cord (2) and only one arose in the temporal horn.
  • Tumors ranged in size from 2.0 mm to 60 mm in greatest dimension (mean, 23.0 mm).
  • Eighteen-percent (15/83) of subependymomas exhibited a mixed histologic pattern; that is, subependymoma together with another glial tumor.
  • All patients were without evidence of disease at the last follow-up: alive (n = 28) or dead (n = 8).
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Ependymoma / pathology. Glioma, Subependymal / pathology. Infratentorial Neoplasms / pathology. Mixed Tumor, Malignant / pathology

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  • (PMID = 17569000.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Chang X, Han J, Pang L, Zhao Y, Yang Y, Shen Z: Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer; 2009;9:40
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  • [Title] Increased PADI4 expression in blood and tissues of patients with malignant tumors.
  • METHODS: Expression of PADI4 was investigated in various tumors and non-tumor tissues (n = 1673) as well as in A549, SKOV3 and U937 tumor cell lines by immunohistochemistry, real-time PCR, and western blot.
  • Levels of PADI4 and citrullinated antithrombin (cAT) were investigated in the blood of patients with various tumors by ELISA (n = 1121).
  • However, PADI4 expression was not observed in benign leiomyomas of stomach, uterine myomas, endometrial hyperplasias, cervical polyps, teratomas, hydatidiform moles, trophoblastic cell hyperplasias, hyroid adenomas, hemangiomas, lymph hyperplasias, schwannomas, neurofibromas, lipomas, and cavernous hemangiomas of the liver.
  • Additionally, PADI4 expression was not detected in non-tumor tissues including cholecystitis, cervicitis and synovitis of osteoarthritis, except in certain acutely inflamed tissues such as in gastritis and appendicitis.
  • Quantitative PCR and western blot analysis showed higher PADI4 expression in gastric adenocarcinomas, lung adenocarcinomas, hepatocellular carcinomas, esophageal squamous cell cancers and breast cancers (n = 5 for each disease) than in the surrounding healthy tissues.
  • Furthermore, western blot analysis detected PADI4 expression in cultured tumor cell lines.
  • ELISA detected increased PADI4 and cAT levels in the blood of patients with various malignant tumors compared to those in patients with chronic inflammation and benign tumors.
  • Additionally, PADI4 and cAT levels were significantly associated with higher levels of known tumor markers.
  • CONCLUSION: Our results suggest that PADI4 expression is increased in the blood and tissues of many malignant tumors, a finding useful for further understanding of tumorigenesis.
  • [MeSH-major] Hydrolases / metabolism. Neoplasm Proteins / metabolism. Neoplasms / metabolism
  • [MeSH-minor] Antithrombins / metabolism. Blotting, Western. Cell Line, Tumor. Citrulline / metabolism. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunohistochemistry. Immunoprecipitation. Male. Polymerase Chain Reaction / methods

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  • (PMID = 19183436.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antithrombins; 0 / Neoplasm Proteins; 29VT07BGDA / Citrulline; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase type IV
  • [Other-IDs] NLM/ PMC2637889
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85. Ge D, You Z: Expression of interleukin-17RC protein in normal human tissues. Int Arch Med; 2008;1(1):19
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  • RESULTS: IL-17RC expression in 51 normal human tissues and two benign tumors (i.e., lymphangioma and parathyroid adenoma) on the tissue microarrays was determined by immunohistochemical staining, using two polyclonal antibodies against IL-17RC.

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  • (PMID = 18928529.001).
  • [ISSN] 1755-7682
  • [Journal-full-title] International archives of medicine
  • [ISO-abbreviation] Int Arch Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2596096
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86. Zimling ZG, Rechnitzer C, Rasmussen M, Petersen BL: Peripheral neuroblastic tumours in eastern Denmark 1972-2002. APMIS; 2007 Jan;115(1):66-74
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  • [Title] Peripheral neuroblastic tumours in eastern Denmark 1972-2002.
  • The peripheral neuroblastic tumour group includes neuroblastoma, ganglioneuroblastoma and ganglioneuroma.
  • Neuroblastoma is the most common extracranial solid tumour of childhood.
  • We have evaluated the histological presentation, MYCN gene status, and clinical course of peripheral neuroblastic tumours diagnosed and treated in eastern Denmark from 1972-2002.
  • 125 patients were diagnosed with peripheral neuroblastic tumour during this 30-year period.
  • The histological material was reviewed and classified into three categories in accordance with the Shimada system: unfavourable histology, favourable histology, and benign tumours.
  • MYCN status was determined by fluorescent in situ hybridization (FISH) on paraffin sections from the primary tumour.
  • 41 tumours showed unfavourable histology, 30 tumours showed favourable histology, 11 were benign, and 43 were unclassifiable due to limited amounts of primary tumour, bad preservation or inaccessibility of the primary tumour necessitating metastatic tumour biopsy for diagnosis.
  • Unfavourable histology was associated with widespread disease (p<0.001).
  • The survival rate in the unclassifiable group was 13%.
  • The study has confirmed the prognostic significance of the Shimada system in the peripheral neuroblastic tumour group in a retrospective material, and has also demonstrated the prognostic superiority of MYCN compared to histological classification, thus reducing the necessary amounts of tumour tissue.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neuroblastoma / diagnosis. Neuroblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics

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  • (PMID = 17223852.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins
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87. George B, Archilli M, Cornelius JF: Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases. Acta Neurochir (Wien); 2006 Jul;148(7):741-9; discussion 749
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  • [Title] Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases.
  • BACKGROUND: Bone tumors located at the cranio-cervical junction (CCJ)are rare.
  • METHODS: Forty-one patients presenting a bone tumor (26 benign and 15 malignant tumors), excluding chordomas, located at the CCJ (including lower third of the clivus, C1 and C2) were observed over 20 years from 1981 to 2001.
  • Vertebral angiography was rarely performed (N=9) and mostly when the diagnosis was doubtful.
  • In some cases the diagnosis was clear but in others, imaging studies showed destructive lesions suggesting a malignancy, which sometimes required a biopsy (N=4).
  • No recurrence in the group of benign tumors was seen during an average follow-up of 6 years (from 2 to 11 years).
  • CONCLUSIONS: Various types of bone tumors may be found at the CCJ.
  • Confusion between benign and malignant tumor or pseudo tumors must be avoided, sometimes requiring a biopsy.
  • [MeSH-major] Axis, Cervical Vertebra / surgery. Bone Neoplasms / surgery. Cervical Atlas / surgery. Neurosurgical Procedures / methods. Occipital Bone / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebral Angiography. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neck Pain / etiology. Neck Pain / physiopathology. Neck Pain / surgery. Neoplasm Metastasis / pathology. Neoplasm Metastasis / radiography. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Retrospective Studies. Spinal Fusion. Tomography, X-Ray Computed. Treatment Outcome. Vertebral Artery / anatomy & histology. Vertebral Artery / pathology. Vertebral Artery / surgery

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  • (PMID = 16708168.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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88. Wang VY, Deviren V, Ames CP: Reconstruction of C-1 lateral mass with titanium mesh cage after resection of an aneurysmal bone cyst of the atlas. J Neurosurg Spine; 2009 Feb;10(2):117-21
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  • Aneurysmal bone cysts (ABCs) are rare benign tumors with a prevalence of 0.14 cases per 100,000 people.
  • This lesion accounts for 1.4% of all primary bone tumors.

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  • (PMID = 19278324.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] D1JT611TNE / Titanium
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89. Trejos H, Caceres A, Segura JL: Monstrous craniopharyngioma. Case presentations and term proposal. Childs Nerv Syst; 2005 Dec;21(12):1049-53; discussion 1054-5
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  • INTRODUCTION: Craniopharyngiomas (CF) are benign tumors, which can be cured by total resection; however, this is not always possible to achieve, thus leading to tumor recurrence.
  • When these tumors achieve disproportionate growth, the treatment is even more difficult, fortunately grotesque CF are not frequent, making experience and data collection more arduous to obtain.
  • CASE REPORTS: Four patients are presented here to illustrate the need for the use of a new term, "monstrous craniopharyngioma," which is proposed with the aim of making the evaluation of the different kinds of treatment available more accurate.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Hypophysectomy / methods. Pituitary Neoplasms / surgery

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  • (PMID = 15759158.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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90. Kucukarslan N, Kirilmaz A, Ulusoy E, Baysan O, Yildirim V, Ozal E, Sahin MA, Tatar H: Eleven-year experience in diagnosis and surgical therapy of right atrial masses. J Card Surg; 2007 Jan-Feb;22(1):39-42
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  • [Title] Eleven-year experience in diagnosis and surgical therapy of right atrial masses.
  • BACKGROUND: Tumors arising from the right atrium are quite rare, and require special care during differential diagnosis for their management.
  • A review of surgical experience with right atrial tumors in 11 patients from our institution has been presented in this article.
  • METHODS: Eleven cases, operated for a tumor mass in the right atrium in our institution between January 1993 and December 2004, were retrospectively reviewed for their clinical presentation, diagnostic workup, method of surgical procedure, and histopathologic findings.
  • RESULTS: Right atrial tumors were diagnosed in 11 patients (6 males and 5 females).
  • The histopathological examination of the surgically removed specimen revealed a benign tumor in eight patients (73%), and a malignant process in three (23%).
  • In eight patients with a benign tumor, atrial myxoma was the leading cause in half of the cases.
  • CONCLUSIONS: Tumors of the right atrium are rarely seen, and necessitate a unique attention during the process of diagnosis and surgical treatment.
  • The differentiation of the right atrial tumors with the diagnostic tools before surgery, the determination of the spreading, and the structural properties of the mass may designate surgical approach and prognosis.
  • [MeSH-major] Cardiac Surgical Procedures / methods. Diagnostic Techniques, Cardiovascular. Heart Atria / surgery. Heart Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Female. Humans. Leiomyoma / diagnosis. Leiomyoma / pathology. Leiomyoma / surgery. Male. Medical Records. Middle Aged. Prognosis. Retrospective Studies. Turkey

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  • (PMID = 17239209.001).
  • [ISSN] 0886-0440
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. While B, Whiteside OJ, Desai V, Gurr P: Sebaceous lymphadenoma: a case report and review of the literature. Ear Nose Throat J; 2010 Aug;89(8):E22-3
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  • Sebaceous lymphadenomas of the salivary glands are rare, benign tumors that are effectively treated by complete excision.
  • The challenge that these tumors present lies in their accurate diagnosis.
  • Because of their histologic similarity to related malignant tumors, such as mucoepidermoid carcinomas and sebaceous lymphadenocarcinomas, misdiagnosis could lead to unnecessarily radical treatment.
  • We highlight the need for careful clinical and histologic diagnosis in tumors of the salivary glands.
  • [MeSH-major] Adenolymphoma / diagnosis. Magnetic Resonance Imaging. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Ultrasonography

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  • (PMID = 20737364.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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92. Al-Khattabi M, Chouillard E, Louboutin A, Fauconnier A, Bader G: Giant pararectal epidermoid tumor mimicking ovarian cyst: combined laparoscopic and perineal surgical approach. J Minim Invasive Gynecol; 2010 Jan-Feb;17(1):113-5
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  • [Title] Giant pararectal epidermoid tumor mimicking ovarian cyst: combined laparoscopic and perineal surgical approach.
  • Epidermoid cysts are benign tumors that can develop in any part of the human body.
  • We report the case of a 58-year-old woman who underwent laparoscopic and perineal excision of a giant pararectal cyst that was discovered during laparoscopy performed for preoperative provisional diagnosis of an adnexal mass detected on an imaging study.
  • To our knowledge, this is the second case of a pararectal cyst excised using combined laparoscopic and perineal approaches.
  • In the hands of skilled laparoscopic surgeons, we suggest a combined laparoscopic and perineal approach for excision of giant pararectal cystic tumors to avert laparotomy.
  • [MeSH-major] Epidermal Cyst / diagnosis. Epidermal Cyst / surgery. Ovarian Cysts / diagnosis. Rectal Diseases / diagnosis. Rectal Diseases / surgery
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Laparoscopy / methods. Middle Aged. Perineum / pathology. Perineum / surgery. Rectum / pathology. Rectum / surgery. Treatment Outcome

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  • [Copyright] Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20129344.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Işik U, Dinçer A, Sav A, Ozek MM: Basal ganglia location of subependymal giant cell astrocytomas in two infants. Pediatr Neurol; 2010 Feb;42(2):157-9
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  • Subependymal giant cell astrocytomas are benign tumors that constitute one of the primary features of tuberous sclerosis.
  • In infants, subependymal giant cell astrocytomas can present with unusual morphology and may feature diffuse basal ganglia involvement and severe calcification.
  • [MeSH-major] Astrocytoma / pathology. Basal Ganglia / pathology. Brain Neoplasms / pathology

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  • (PMID = 20117758.001).
  • [ISSN] 1873-5150
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Prochazka M, Feychting M, Ahlbom A, Edwards CG, Nise G, Plato N, Schwartzbaum JA, Forssén UM: Occupational exposures and risk of acoustic neuroma. Occup Environ Med; 2010 Nov;67(11):766-71
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  • OBJECTIVES: Acoustic neuroma is a benign tumour accounting for approximately 6-10% of all intracranial tumours and occurs mainly in patients aged ≥50 years.
  • Logistic regression was used to estimate ORs and calculate 95% CIs.
  • We found no convincing evidence that SES is related to disease development.
  • Men working as truck and conveyor operators <10 years before the reference year had the highest increased risk of acoustic neuroma, but it is unclear what in those occupations might contribute to disease development.

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  • (PMID = 20581419.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dust; FXS1BY2PGL / Mercury; J64922108F / Benzene
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95. Cai B, Zhou L, An H, Chen J, Hui X, Qiao X, Liu J, Jiang S: [Early outcome of one-stage transnasal surgery combined with transnasal surgery for cranionasal tumors and reconstruction of skull base]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 May;22(5):589-92
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  • [Title] [Early outcome of one-stage transnasal surgery combined with transnasal surgery for cranionasal tumors and reconstruction of skull base].
  • OBJECTIVE: To investigate the microsurgical management of cranionasal tumors and the method of the reconstruction of the skull base.
  • METHODS: From June 2005 to October 2007, 20 patients with cranionasal tumor were treated.
  • The disease course was 2 months to 13 years.
  • The cranionasal tumors, proved by MRI and CT scans, located in the anterior skull base, paranasal sinus, nasal and/or orbit cavity.
  • And their clinical presentations were listed as follows: dysosphresia in 14 patients, headache in 11 patients, nasal obstruction in 9 patients, epistaxis in 8 patients, visual disorder in 4 patients, exophthalmos in 4 patients and conscious disturbance in 2 patients.
  • All 20 patients underwent transnasal surgery combined with transnasal surgery, and tumors were resected by one-stage operation.
  • RESULTS: Tumors were resected by one-stage operation, and the anterior skull bases were reconstructed.
  • Pathological examination showed 8 cases of malignant tumors and 12 cases of benign tumors.
  • And recurrence of tumor was observed in 5 patients 3 months to 2 years after operation.
  • CONCLUSION: Microsurgical operation via subfrontal approach assisted by transnasal endoscopy is an effective method in management of cranionasal tumors, with the advantages of reconstruction of the skull base with pedicle periosteum flap or "Pull Down Sandwich" and low complication rate.
  • [MeSH-major] Skull Base / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Endoscopy. Female. Humans. Male. Microsurgery. Middle Aged. Neurosurgical Procedures. Nose Neoplasms / surgery. Reconstructive Surgical Procedures

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  • (PMID = 18630443.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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96. Amin RM, Hiroshima K, Miyagi Y, Kokubo T, Hoshi K, Fujisawa T, Nakatani Y: Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung. Pathol Int; 2008 Jan;58(1):38-44
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  • Because pathophysiology of several syndromes associated with benign tumors may converge on the tuberous sclerosis complex (TSC), serine/threonine kinase 11 (STK11), and mammalian target of rapamycin (mTOR) pathways, the purpose of the present paper was to investigate their roles in the development of SH.

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  • (PMID = 18067639.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] EC 2.7.- / Protein Kinases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.- / STK11 protein, human; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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97. Sheikh MA, Akhtar J, Batool T, Naqvi R, Taqvi R, Jalil S, Soomro A, Ahmed S, Mirza F: A study of ovarian lesions in pre-menarche girls. J Coll Physicians Surg Pak; 2007 Mar;17(3):162-5
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  • Age of the patients, presenting symptoms, investigations performed, surgical approaches, operative findings and final histological diagnosis were noted.
  • Ovarian lesions were classified according to WHO criteria.System proposed by the Children's Cancer Group and the Paediatric Oncology Group was used for staging of tumors.
  • Following resection, patients with malignant tumors were followed-up by oncologist.
  • Six patients had non-tumorous cysts, 3 had benign tumors and 9 were with malignant lesions.
  • Of the non-tumorous cysts, 3 patients had simple follicular cysts and 2 were hemorrhagic cysts.
  • There were 2 patients with benign teratoma and one with dermoid cyst.
  • Four patients had malignant teratoma, 4 dysgerminoma and one yolk sac tumor.
  • Malignant tumors were all of stage IA according to Paediatric Oncology Group staging.
  • CONCLUSION: Ovarian tumors are rare in paediatric age group especially in pre-menarche girls.
  • Except one, all malignant tumors were found in patients above 7 years of age.
  • Benign (tumorous and non-tumorous) and malignant lesions occurred with equal frequency in pre-menarche girls in this study.

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  • (PMID = 17374303.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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98. Wierinckx A, Auger C, Devauchelle P, Reynaud A, Chevallier P, Jan M, Perrin G, Fèvre-Montange M, Rey C, Figarella-Branger D, Raverot G, Belin MF, Lachuer J, Trouillas J: A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. Endocr Relat Cancer; 2007 Sep;14(3):887-900
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  • [Title] A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors.
  • Although most pituitary tumors are benign, some are invasive or aggressive.
  • In the absence of specific markers of malignancy, only tumors with metastases are considered malignant.
  • To identify markers of invasion and aggressiveness, we focused on prolactin (PRL) tumors in the human and rat.
  • Using radiology and histological methods, we classified 25 human PRL tumors into three groups (non-invasive, invasive, and aggressive-invasive) and compared them with a model of transplantable rat PRL tumors with benign and malignant lineages.
  • Combining histological(mitoses and labeling for Ki-67, P53, pituitary transforming tumor gene (PTTG), and polysialic acid neural cell adhesion molecule) and transcriptomic (microarrays and q-RTPCR) methods with clinical data (post-surgical outcome with case-control statistical analysis), we found nine genes implicated in invasion (ADAMTS6, CRMP1, and DCAMKL3) proliferation (PTTG, ASK, CCNB1, AURKB, and CENPE), or pituitary differentiation (PITX1) showing differential expression in the three groups of tumors (P = 0.015 to 0.0001).
  • A case-control analysis, comparing patients in remission (9 controls) and patients with persistent or recurrent tumors (14 cases) revealed that eight out of the nine genes were differentially up- or downregulated (P = 0.05 to 0.002), with only PTTG showing no correlation with clinical course (P = 0.258).
  • These combined histological and transcriptomic analyses improve the pathological diagnosis of PRL tumors, indicating a reliable procedure for predicting tumor aggressiveness and recurrence potential.
  • The similar gene profiles found between non-invasive human and benign rat tumors, as well as between aggressive-invasive human and malignant rat tumors provide new insights into malignancy in human pituitary tumors.
  • [MeSH-major] Biomarkers, Tumor / isolation & purification. Cell Proliferation. Molecular Diagnostic Techniques. Pituitary Neoplasms / genetics. Pituitary Neoplasms / pathology. Prolactinoma / genetics. Prolactinoma / pathology
  • [MeSH-minor] Animals. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Male. Neoplasm Invasiveness. Neoplasm Metastasis. Oligonucleotide Array Sequence Analysis. Prognosis. Rats. Rats, Wistar

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  • (PMID = 17914117.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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99. Li JS, Chen WL, Huang ZQ, Zhang DM: Pediatric mandibular reconstruction after benign tumor ablation using a vascularized fibular flap. J Craniofac Surg; 2009 Mar;20(2):431-4
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  • [Title] Pediatric mandibular reconstruction after benign tumor ablation using a vascularized fibular flap.
  • Six pediatric patients ranging in age from 12 to 15 years underwent mandibular reconstruction using a vascularized fibula flap with a skin paddle, after benign tumor ablation.
  • A vascularized fibular flap is a very reliable method for reconstructing the pediatric mandible after benign tumor ablation.
  • [MeSH-major] Bone Transplantation / methods. Mandible / surgery. Mandibular Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skin Transplantation / methods. Surgical Flaps

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  • (PMID = 19218857.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Chakrapani SD, Grim K, Kaimaktchiev V, Anderson JC: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976); 2008 Dec 1;33(25):E968-70
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  • SUMMARY OF BACKGROUND DATA: Osteoblastoma is a rare benign tumor of bone that is known to incite a localized inflammatory response.
  • These inflammatory features can simulate malignant behavior on MRI and can lead to misdiagnosis and unnecessarily aggressive resection unless one recognizes the classic benign features on CT.
  • RESULTS: A 9-year-old girl with back pain receives an MRI of the lumbar spine demonstrating a sacral tumor with potentially malignant features including extensive marrow edema and enhancement.
  • A benign lesion was favored given the CT features and conservative resection was performed.
  • Final pathologic diagnosis was osteoblastoma.
  • CONCLUSION: This case illustrates that the MRI findings for osteoblastoma can be misleading and caution should be used when evaluating benign tumors with known inflammatory responses on MRI.
  • CT features seem to more accurately reflect the true nature and extent of the tumor.
  • [MeSH-major] Magnetic Resonance Imaging. Osteoblastoma / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Inflammation / diagnosis. Inflammation / radiography. Inflammation / surgery. Lumbar Vertebrae / pathology. Lumbar Vertebrae / radiography. Lumbar Vertebrae / surgery

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  • (PMID = 19050575.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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