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1. Kavanagh DO, O'Riain C, Ridgway PF, Neary P, Crotty TC, Geoghegan JG, Traynor O: Radical pancreaticoduodenectomy for benign disease. ScientificWorldJournal; 2008;8:1156-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radical pancreaticoduodenectomy for benign disease.
  • Preoperative histological confirmation of malignancy is frequently unavailable and some patients will subsequently be found to have benign disease.
  • Here, we review our experience with Whipple's procedure for patients ultimately proven to have benign disease.
  • In eight cases, the final histology was benign (7.1%).
  • One additional patient was known to have benign disease at resection.
  • The pathological diagnosis included benign biliary stricture (two), chronic pancreatitis (two), choledochal cyst (one), inflammatory pseudotumour (one), cystic duodenal wall dysplasia (one), duodenal angiodysplasia (one), and granular cell neoplasm (one).
  • Morbidity included intra-abdominal collection (one), anastomotic leak (one), liver abscess (one), and myocardial infarction (one).
  • Despite recent advances in diagnostic imaging, 8% of the patients undergoing Whipple's procedure had benign disease.
  • Endoscopic ultrasound-guided fine needle aspirate (EUS-FNA) may reduce the need for Whipple's operation in benign pancreaticobiliary disease in the future.

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  • (PMID = 19030761.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Matull WR, Andreola F, Loh A, Adiguzel Z, Deheragoda M, Qureshi U, Batra SK, Swallow DM, Pereira SP: MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Br J Cancer; 2008 May 20;98(10):1675-81
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  • [Title] MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer.
  • Alterations in epithelial mucin expression are associated with carcinogenesis, but there are few data in biliary tract cancer (BTC).
  • In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as a sensitive serological marker for BTC.
  • We assessed MUC4 and MUC5AC expression in (i) prospectively collected bile and serum specimens from 72 patients with biliary obstruction (39 BTC) by real-time reverse transcriptase-PCR (qPCR) and western blot analysis, and (ii) 79 archived biliary tissues (69 BTC) by immunohistochemistry.
  • In bile, MUC4 protein was detected in 27% of BTC and 29% of primary sclerosing cholangitis (PSC) cases, but not in other benign and malignant biliary diseases (P<0.01 and P=0.06).
  • qPCR revealed a 1.9-fold increased MUC4 mRNA expression in BTC patients' bile compared with benign disease.
  • In archived tissues, MUC4 protein was detected in 37% of BTC but in none of the benign samples (P=0.03).
  • Biliary MUC4 and serum MUC5AC are highly specific tumour-associated mucins that may be useful in the diagnosis and formulation of therapeutic strategies in BTC.
  • [MeSH-major] Bile / metabolism. Biliary Tract Neoplasms / metabolism. Biomarkers, Tumor / metabolism. Mucins / blood. Mucins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blotting, Western. Female. Follow-Up Studies. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Mucin 5AC. Mucin-4. Neoplasm Staging. Predictive Value of Tests. Prospective Studies. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18475301.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0801588; United Kingdom / Cancer Research UK / / C24036/A7839
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC4 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-4; 0 / Mucins
  • [Other-IDs] NLM/ PMC2391120
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3. Siriwardana PN, Pathirana A: Episodic biliary obstruction due to an intrahepatic biliary cystadenoma: a case report. J Med Case Rep; 2009;3:9032

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Episodic biliary obstruction due to an intrahepatic biliary cystadenoma: a case report.
  • INTRODUCTION: Biliary cystadenoma is a rare, benign neoplasm of the bile ducts with malignant potential.
  • Symptoms, predominantly right hypochondrial pain and the feeling of a lump or fullness are usually due to the mass effect.
  • This is the fifth reported patient with an intrahepatic biliary cystadenoma giving rise to episodic biliary obstruction, which is usually caused by choledocholithiasis or periampullary carcinoma.
  • CASE PRESENTATION: A 25-year-old Asian woman presented with right hypochondrial pain and episodic biliary obstruction.
  • Laparotomy confirmed the contrast enhanced computed tomography findings and histology revealed an intrahepatic mucinous biliary cystadenoma.
  • CONCLUSION: Biliary cystadenoma should be considered as a differential diagnosis in patients with cystic liver lesions who present with episodic biliary obstruction.

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  • (PMID = 19918286.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2767148
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4. Zhou JP, Dong M, Zhang Y, Kong FM, Guo KJ, Tian YL: Giant mucinous biliary cystadenoma: a case report. Hepatobiliary Pancreat Dis Int; 2007 Feb;6(1):101-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mucinous biliary cystadenoma: a case report.
  • BACKGROUND: Biliary cystadenoma is a very rare cystic neoplasm of the liver.
  • METHODS: A 40-year-old woman with a mass of the liver was verified by ultrasonography and LT.
  • Ultrasonography showed a mixed echo of 18.4 cm x 14.72 cm x 15.54 cm in the left lobe of the liver.
  • Her biliary cystadenoma was characterized by specific histological findings.
  • The whole left lobe with a small amount of normal liver tissue close to the deltoid ligament.
  • The interior wall was lined with bile duct tissue, indicating a benign mucinous biliary cystadenoma.
  • CONCLUSIONS: Ultrasonography and CT are the major methods for the diagnosis of mucinous biliary cystadenoma liver.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cystadenoma, Mucinous / diagnosis. Cystadenoma, Mucinous / surgery

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  • (PMID = 17287176.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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5. Locke JE, Choti MA, Torbenson MS, Horton KM, Molmenti EP: Inflammatory pseudotumor of the liver. J Hepatobiliary Pancreat Surg; 2005;12(4):314-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inflammatory pseudotumor of the liver.
  • Inflammatory pseudotumor of the liver (IPL) is a rare benign neoplasm.
  • It often masquerades as a malignancy, either primary or metastatic.
  • We describe the case of a 71-year-old man who presented with fever and malaise.
  • Workup revealed a cecal mass, as well as a lesion in the left lobe of the liver.
  • Pathologic examination showed a cecal neoplasm and a hepatic inflammatory pseudotumor.
  • This case highlights the ability of IPL to masquerade as a malignant hepatic neoplasm, and emphasizes the difficulties in diagnosis.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Liver Diseases / diagnosis

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  • (PMID = 16133699.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Larghi A, Tringali A, Lecca PG, Giordano M, Costamagna G: Management of hilar biliary strictures. Am J Gastroenterol; 2008 Feb;103(2):458-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of hilar biliary strictures.
  • Biliary strictures at the liver hilum are caused by a heterogeneous group of benign and malignant conditions.
  • In the absence of a clear-cut benign etiology, i.e. bile duct damage during surgery, hilar biliary strictures remain a diagnostic and therapeutic challenge for which a multidisciplinary approach is often necessary.
  • Because these tumors frequently extend longitudinally via the hepatic ducts into the liver parenchyma, partial hepatic resection has been gradually added to biliary resection to ensure tumor-free surgical margins.
  • For unresectable cases, endoscopic stenting of biliary obstruction is considered the preferred palliation modality to relieve pruritus, cholangitis, pain and jaundice, while the percutaneous approach has been reserved for cases of failure.
  • For benign post surgical hilar strictures, surgical repair can be difficult and requires specific skills and experience.
  • [MeSH-major] Bile Duct Neoplasms. Hepatic Duct, Common
  • [MeSH-minor] Bile Duct Diseases / diagnosis. Bile Duct Diseases / etiology. Bile Duct Diseases / therapy. Humans. Neoplasm Staging

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  • (PMID = 18028506.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 153
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7. Troisi R, Montalti R, Smeets P, Van Huysse J, Van Vlierberghe H, Colle I, De Gendt S, de Hemptinne B: The value of laparoscopic liver surgery for solid benign hepatic tumors. Surg Endosc; 2008 Jan;22(1):38-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of laparoscopic liver surgery for solid benign hepatic tumors.
  • BACKGROUND: Laparoscopic liver resection (LLR) has gained wide acceptance for various liver resection procedures, mainly for benign diseases.
  • METHODS: Between January 2001 and January 2006, a total of 629 liver resections were performed at our institution.
  • The indication was solid benign liver tumor in 56 (8.9%) patients.
  • Data from the LLR group were compared with those from a consecutive control group undergoing open liver surgery (OS) for similar indications in a matched-pair analysis during the same period.
  • Bleeding is a major risk and should be carefully considered when resecting benign tumors.
  • In the hands of expert surgeons, LLR may become the gold standard for the resection of benign liver tumors located in the anterior and lateral sectors and for minor hepatic resections.
  • [MeSH-major] Hepatectomy / methods. Laparoscopy / methods. Liver Neoplasms / pathology. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Laparotomy / adverse effects. Laparotomy / methods. Length of Stay. Male. Middle Aged. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Pain, Postoperative / physiopathology. Probability. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • (PMID = 17705077.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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8. Ramacciato G, Nigri GR, D'Angelo F, Aurello P, Bellagamba R, Colarossi C, Pilozzi E, Del Gaudio M: Emergency laparotomy for misdiagnosed biliary cystadenoma originating from caudate lobe. World J Surg Oncol; 2006;4:76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Emergency laparotomy for misdiagnosed biliary cystadenoma originating from caudate lobe.
  • BACKGROUND: Biliary cystadenoma is a rare benign neoplasm, which is often misdiagnosed for a hepatic abscess or a hydatid cyst that tends to recur and is at risk for progression to malignant neoplasm.
  • Histologic evaluation of the cyst showed that it was a biliary cystadenoma and, therefore, the patient underwent a hepatic resection in order to completely remove the lesion.
  • Incomplete excision of most biliary cystadenoma results in a higher rate of recurrence and the risk of malignant transformation.

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  • (PMID = 17090300.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1635700
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9. Hohmann J, Loddenkemper C, Albrecht T: Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents. Ultraschall Med; 2009 Apr;30(2):185-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents.
  • US revealed signs of cirrhosis and a hyporeflexive focal liver lesion of about 5 mm in diameter was found.
  • Low-MI contrast-enhanced ultrasound (CEUS) with SonoVue (Bracco, Milano, Italy) showed an enhancement pattern which was typical for benign liver lesions while high-MI CEUS with Levovist (Schering, Berlin, Germany) revealed a contrast defect in the liver late phase (4:30 min p. i.) which is typical for a malignant lesion.
  • Due to these findings the lesion was evaluated as a potentially malignant lesion and a biopsy was performed.
  • Histology showed a benign biliary hamartoma and incomplete cirrhosis.
  • The findings confirmed that liver-specific contrast agents have the ability to detect very small focal liver lesions not derived from hepatic tissue but may lead to a misinterpretation as a malignant lesion.
  • Nevertheless biliary duct adenomas are benign lesions with almost the same perfusion properties as normal liver parenchyma.
  • [MeSH-major] Adenoma, Bile Duct / ultrasonography. Bile Duct Diseases / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic / ultrasonography. Contrast Media. Hamartoma / ultrasonography. Phospholipids. Polysaccharides. Sulfur Hexafluoride. Ultrasonography, Doppler, Duplex
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Esophageal Neoplasms / pathology. Esophageal Neoplasms / ultrasonography. Humans. Incidental Findings. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / ultrasonography. Male. Middle Aged. Neoplasm Staging. Sensitivity and Specificity

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  • (PMID = 18726842.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / Polysaccharides; 0 / contrast agent BR1; 127279-08-7 / SHU 508; WS7LR3I1D6 / Sulfur Hexafluoride
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10. Espinel Diez J, Vivas Alegre S, Muñoz Núñez F, Domínguez Carbajo A, Villanueva Pavón R, Jorquera Plaza F, Olcoz Goñi JL: [Needle-knife sphincterotomy for biliary access: a prospective study]. Gastroenterol Hepatol; 2005 Aug-Sep;28(7):369-74

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  • [Title] [Needle-knife sphincterotomy for biliary access: a prospective study].
  • [Transliterated title] Esfinterotomía de aguja como técnica de acceso a la vía biliar: estudio prospectivo.
  • OBJECTIVE: Needle-knife sphincterotomy (NKS) is used to achieve biliary access when routine cannulation methods have been unsuccessful.
  • The aim of this study was to analyze the results of NNS in patients with an inaccessible common bile duct (difficult cannulation) using standard techniques in endoscopic retrograde cholangiopancreatography and the factors associated with the success of this procedure and complications.
  • MATERIAL AND METHODS: We performed a prospective study of 72 patients who underwent NKS performed by the same endoscopist (J.E.) because of difficult cannulation of the common bile duct between January 1998 and December 2004.
  • The results were analyzed in terms of successful biliary access, whether this was achieved in one or more sessions, its possible association with the underlying disease, and the incidence and severity of complications.
  • A total of 77.7% of the patients underwent prior implantation of a pancreatic prosthesis (NKS-PP).
  • The final diagnosis was: choledocholithiasis (31.9%), cancer of the pancreas (16.6%), cholangiocarcinoma (13.8%), benign stenosis (8.3%), dysfunction of the sphincter of Oddi (6.9%), normal (6.9%), and miscellaneous (13.8%).
  • Biliary access was achieved in 72.7% of patients (16/22) with biliopancreatic neoplasms versus 94% (47/50) of those with other diagnoses (p = 0.03).
  • The use of a pancreatic prosthesis was related to a higher success rate and significantly fewer complications (p = 0.03).
  • CONCLUSIONS: NKS-PP can be a safe procedure in patients with difficult cannulation of the common bile duct.
  • The presence of biliopancreatic neoplasm is a risk factor for failure to achieve biliary access compared with other diagnoses.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater / injuries. Cholangiocarcinoma / diagnosis. Cholangitis / etiology. Choledocholithiasis / diagnosis. Common Bile Duct Neoplasms / diagnosis. Constriction, Pathologic. Female. Hemorrhage / etiology. Humans. Liver Neoplasms / diagnosis. Male. Middle Aged. Pancreatic Neoplasms / diagnosis. Pancreatitis / etiology. Postoperative Complications / etiology. Prospective Studies. Sphincter of Oddi / pathology. Stents

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  • (PMID = 16137469.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 40
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11. Peddu P, Huang D, Kane PA, Karani JB, Knisely AS: Vanishing liver tumours. Clin Radiol; 2008 Mar;63(3):329-39
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  • [Title] Vanishing liver tumours.
  • Spontaneous resolution of liver tumours is a rare, but recognized entity that has been reported to occur within the spectrum of benign and malignant liver tumours occurring in both adult and paediatric population.
  • In this article we present case examples of various benign and malignant liver tumours that have regressed spontaneously without treatment together with a review of the literature, and a summary of the current understanding of the pathogenesis of these tumours.
  • [MeSH-major] Liver Neoplasms / diagnosis. Neoplasm Regression, Spontaneous
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adult. Aged. Biliary Tract Diseases / diagnosis. Carcinoma, Hepatocellular / diagnosis. Female. Granuloma, Plasma Cell / diagnosis. Hemangioendothelioma / diagnosis. Humans. Infant. Infant, Newborn. Liver Diseases / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, Spiral Computed. Tomography, X-Ray Computed. Ultrasonography, Doppler, Color

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  • (PMID = 18275874.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 43
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12. van Baardewijk LJ, Idenburg FJ, Clahsen PC, Möllers MJ: [Von Meyenburg complexes in the liver: not metastases]. Ned Tijdschr Geneeskd; 2010;154:A1674
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  • [Title] [Von Meyenburg complexes in the liver: not metastases].
  • [Transliterated title] Von meyenburg-complexen in de lever: geen metastasen.
  • Multiple lesions of the liver were discovered as incidental findings.
  • Histopathology revealed that these were Von Meyenburg complexes (VMCs).
  • VMCs, also called biliary hamartomas, are rare and benign malformations of the bile ducts.
  • The lesions present as diffuse greyish-white to greyish-yellow or black nodules of the liver, which on gross inspection and in radiological examinations strongly resemble liver metastases.
  • Intraoperative frozen section analysis to differentiate between malignant and benign lesions has a sensitivity of 97% and a specificity of 99%.
  • The benign nature of VMCs means that they do not require treatment.
  • [MeSH-major] Hamartoma / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Aged. Bile Ducts / abnormalities. Bile Ducts / pathology. Carcinoma / pathology. Carcinoma / surgery. Diagnosis, Differential. Female. Humans. Incidental Findings. Liver / pathology. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery

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  • (PMID = 20619020.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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13. Vennarecci G, Ettorre GM, Giovannelli L, Del Nonno F, Perracchio L, Visca P, Corazza V, Vidiri A, Visco G, Santoro E: Solitary fibrous tumor of the liver. J Hepatobiliary Pancreat Surg; 2005;12(4):341-4
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  • [Title] Solitary fibrous tumor of the liver.
  • We report a new case of benign solitary fibrous tumor (SFT) of the liver.
  • Ultrasonography and computed tomography showed a large tumor, 20 cm in diameter, in the right lobe of the liver.
  • Microscopic evaluation showed a benign SFT of the liver with tumor cells typically positive for vimentin and CD34.
  • This is a rare neoplasm of mesenchymal origin that occasionally involves the liver in adult patients.
  • Most SFTs are benign, but some may have malignant histological features and recur locally or metastasize.
  • As SFT of the liver is often a benign neoplasm, chemotherapy or radiotherapy should not be necessary, and should be reserved for when resection is incomplete and/or histological examination reveals features of malignancy.
  • Surgeons must be aware of SFT of the liver, and this neoplasm should be included in the differential diagnosis of a single large hepatic mass.
  • [MeSH-major] Liver Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology

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  • (PMID = 16133706.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Plard L, Leone S, Rod J, Chiche L: [Adenomyoma of the main biliary tract: a real diagnostic trap. Two cases and a review of the literature]. Gastroenterol Clin Biol; 2007 Nov;31(11):1005-9

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  • [Title] [Adenomyoma of the main biliary tract: a real diagnostic trap. Two cases and a review of the literature].
  • [Transliterated title] L'adénomyome de la voie biliaire principale: un vrai piège diagnostique. Deux cas et revue de la littérature.
  • Adenomyoma of the biliary tract is a benign neoplasm but its clinical, radiological and intraoperative features can mimic pancreatic or biliary cancer.
  • [MeSH-major] Adenomyoma / diagnosis. Biliary Tract Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cholangiography. Humans. Liver / ultrasonography. Male. Pancreaticoduodenectomy. Preoperative Care

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  • (PMID = 18166896.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 47
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15. Cione GP, Cerbone D, Di Benedetto A, Podio P, Cimmino G, Parmeggiani D, Peltrini A, Lombardi V, Perrotta M: [Intrahepatic biliary cystadenoma: case report]. Suppl Tumori; 2005 May-Jun;4(3):S48-50
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  • [Title] [Intrahepatic biliary cystadenoma: case report].
  • According to the OMS classification of the epithelial benign neoplasm of the liver, the adenomas represent the most important group.
  • The biliar cistoadenoma (BCA) represents a not frequent neoplasm of the liver that has origin on the inside of the liver, and less frequently from the extrahepatic biliar system.
  • The real difficulty is represented by differential diagnosis from the other cystic lesions of the liver and by the need of its radical excision and therefore of real hepatectomy.
  • [MeSH-major] Bile Duct Neoplasms. Bile Ducts, Intrahepatic. Cystadenoma

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  • (PMID = 16437897.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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16. Cox H, Ma M, Bridges R, Debru E, Bathe O, Sutherland F, Dixon E: Well differentiated intrahepatic cholangiocarcinoma in the setting of biliary papillomatosis: a case report and review of the literature. Can J Gastroenterol; 2005 Dec;19(12):731-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Well differentiated intrahepatic cholangiocarcinoma in the setting of biliary papillomatosis: a case report and review of the literature.
  • However, serial computed tomography scans revealed a rapidly progressive mass in segment 2 of the liver.
  • Surprisingly, surgical pathology revealed a well-differentiated intrahepatic cholangiocarcinoma associated with biliary papillomatosis (BP).
  • BP is a rare, benign and potentially fatal disease of the intra- and extrahepatic bile ducts.
  • It is typified by numerous multicentric papillary fronds arising from biliary columnar epithelium.
  • Although a benign disease, a review of the literature demonstrated that BP often recurs after surgical resection, carries a poor prognosis and has a moderately high malignant transformation rate.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Papilloma / pathology
  • [MeSH-minor] Bile Ducts / pathology. Biopsy, Needle. Cholangiopancreatography, Endoscopic Retrograde / methods. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Male. Middle Aged. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16341314.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 15
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17. Ba-Ssalamah A, Fakhrai N, Matzek WK, Herneth AM, Stadler A, Bastati N, Herold CJ, Schima W: Magnetic resonance imaging of liver malignancies. Top Magn Reson Imaging; 2007 Dec;18(6):445-55
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  • [Title] Magnetic resonance imaging of liver malignancies.
  • The histological structure of the liver is complex, consisting of hepatocytes, biliary epithelium, and mesenchymal cells.
  • From this large variety of cells, a broad spectrum of benign and malignant liver lesions in originate.
  • With the recent developments in hardware and software, magnetic resonance imaging (MRI) has emerged as the method of choice in the diagnostic workup of focal liver lesions, in particular in the pretherapeutic stage.
  • The introduction of high-field MRI at 3.0 T in the routine workup and the selective use of liver-specific contrast agents, including hepatobiliary and reticuloendothelial agents, have also strengthened the role of MRI in liver imaging.
  • In this overview article, we will review the recent developments in 3.0-T MRI and MRI contrast agents in the diagnostic workup of the most common malignant liver tumors.
  • [MeSH-major] Liver Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Contrast Media. Humans. Neoplasm Metastasis / diagnosis. Neoplasm Staging

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  • (PMID = 18303402.001).
  • [ISSN] 0899-3459
  • [Journal-full-title] Topics in magnetic resonance imaging : TMRI
  • [ISO-abbreviation] Top Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 64
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18. Makdissi FF, Surjan RC, Machado MA: Laparoscopic enucleation of liver tumors. Corkscrew technique revisited. J Surg Oncol; 2009 Mar 1;99(3):166-8
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  • [Title] Laparoscopic enucleation of liver tumors. Corkscrew technique revisited.
  • This article describes a simple laparoscopic technique for enucleation of liver tumors.
  • Ultrasonography is used to ascertain surgical margin right before liver transection.
  • The suture is held together by metallic clips and upward traction is performed, facilitating the transection of the parenchyma and correct identification of vascular and biliary structures.
  • Four patients underwent liver resection for malignant disease and two for benign liver neoplasm.
  • CONCLUSION: This technique may facilitate laparoscopic nonanatomical liver resection and reduce risk of positive surgical margins.
  • It is also useful in combination with anatomical laparoscopic liver resections such as right or left hemihepatectomies in patients with bilateral liver tumors as occurred in one of our patients.
  • [MeSH-major] Hepatectomy. Laparoscopy. Liver Neoplasms / surgery
  • [MeSH-minor] Feasibility Studies. Female. Humans. Length of Stay. Male. Middle Aged. Neoplasm Staging. Suture Techniques. Treatment Outcome

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  • (PMID = 19065641.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Vassiliou I, Kairi-Vassilatou E, Marinis A, Theodosopoulos T, Arkadopoulos N, Smyrniotis V: Malignant potential of intrahepatic biliary papillomatosis: a case report and review of the literature. World J Surg Oncol; 2006;4:71
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  • [Title] Malignant potential of intrahepatic biliary papillomatosis: a case report and review of the literature.
  • BACKGROUND: Biliary papillomatosis (BP) is a rare disease entity with a strong malignant potential.
  • It is characterized by multiple papillary adenomas involving both the intrahepatic and extrahepatic biliary tree.
  • However, a current review of the English literature revealed a high rate of malignant occurrence of approximately 41% and histological analysis along with the expression pattern of mucin core proteins (MUC) and mucin carbohydrate antigens suggests that BP is a borderline or low grade malignant neoplasm with a high malignant potential.
  • Imaging workup demonstrated dilatation of the left hepatic duct without the presence of a space-occupying lesion.
  • A left hepatectomy and cholecystectomy were carried out and histological analysis revealed a moderately to poorly differentiated carcinoma of the left hepatic duct in the background of biliary papillomatosis.
  • CONCLUSION: BP should not be considered to be a benign disease.
  • The clinical behavior, the high recurrence rate and the even higher malignant transformation occurrence, as well as the presence of carcinogenetic indicators (K-ras mutation, overexpression of p53, MUC and Tn antigens) strongly support that BP is a low-grade neoplasm with high malignant potential.

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  • [ISO-abbreviation] World J Surg Oncol
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20. Athanasios P, Alexandros P, Nicholas B, Dimitrios K, Kostantinos B, Antonio M, Efstathios P: Pleomorphic giant cell carcinoma of the pancreas with hepatic metastases--initially presenting as a benign serous cystadenoma: a case report and review of the literature. HPB Surg; 2010;2010:627360
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  • [Title] Pleomorphic giant cell carcinoma of the pancreas with hepatic metastases--initially presenting as a benign serous cystadenoma: a case report and review of the literature.
  • INTRODUCTION: Pleomorphic giant cell pancreatic cancer is a very rare and aggressive pancreatic neoplasm.
  • A case of pleomorphic giant cell pancreatic cancer presenting as a cystic lesion and in association with a serous cystadenoma presents a unique case which has not been described before.
  • Repeat scans demonstrated mild cyst enlargement with new liver lesions.
  • [MeSH-major] Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / secondary. Cystadenoma, Serous / diagnosis. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Pancreatic Neoplasms / diagnosis

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  • (PMID = 21197435.001).
  • [ISSN] 1607-8462
  • [Journal-full-title] HPB surgery : a world journal of hepatic, pancreatic and biliary surgery
  • [ISO-abbreviation] HPB Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3010638
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21. Nomura N, Fujii T, Kanazumi N, Takeda S, Nomoto S, Kasuya H, Sugimoto H, Yamada S, Nakao A: Nonfunctioning neuroendocrine pancreatic tumors: our experience and management. J Hepatobiliary Pancreat Surg; 2009;16(5):639-47
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  • METHODS: The records of 17 patients with NFNPTs operated on between 1998 and 2008 were retrospectively reviewed, and all tumors were classified clinicopathologically as benign, uncertain, and malignant, based on the World Health Organization (WHO) classification of neuroendocrine tumors.
  • RESULTS: There were four benign, six uncertain, and seven malignant NFNPTs.
  • Mean tumor size of benign, uncertain, and malignant tumors were 1.0 +/- 0.3, 3.2 +/- 1.6, and 5.3 +/- 2.4 cm, respectively.
  • Metastatic lesions of malignant tumors were lymph node (six patients), liver (four patients), and adrenal gland (one patient).
  • Two patients underwent more rejection, three patients received systemic chemotherapy, and two patients underwent radiofrequency ablation and transcatheter arterial chemoembolization for liver metastases.
  • Survival of patients with malignant tumors was significantly shorter than that of patients with benign and uncertain tumors.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / therapy. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Chemotherapy, Adjuvant. Cohort Studies. Female. Follow-Up Studies. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Pancreatectomy / methods. Probability. Retrospective Studies. Risk Assessment. Severity of Illness Index. Statistics, Nonparametric. Survival Analysis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19365596.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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22. Jhala NC, Eltoum IA, Eloubeidi MA, Meara R, Chhieng DC, Crowe DR, Jhala D: Providing on-site diagnosis of malignancy on endoscopic-ultrasound-guided fine-needle aspirates: should it be done? Ann Diagn Pathol; 2007 Jun;11(3):176-81
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  • METHODS: Four hundred eighty-five endoscopic ultrasound fine-needle aspirates from the pancreas (n= 305), lymph nodes (n = 91), biliary tree (n = 47), liver (n = 15), gastrointestinal tract (n = 19), and adrenal gland (n = 8) were reviewed.
  • RESULTS: Of the 485 cases, 163 (33.6%) were diagnosed as benign, 43 (8.8%) as atypical, 21 (4.3%) as suspicious, 18 (3.7%) as positive for neoplasm, and 230 (47.4%) as malignant after final cytologic interpretation.
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / pathology. Adult. Aged. Aged, 80 and over. Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Neoplasms / pathology. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Middle Aged. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 17498591.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Zhang M, Yu J, Yan S, Zheng SS: Cystadenocarcinoma of the liver: a case report. Hepatobiliary Pancreat Dis Int; 2005 Aug;4(3):464-7
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  • [Title] Cystadenocarcinoma of the liver: a case report.
  • BACKGROUND: Biliary cystadenocarcinoma as a very rare hepatic neoplasm may be difficult to distinguish from simple hepatic cysts, especially in the unilocular form.
  • RESULTS: In all patients who received liver lobectomy, primary hepatic cystadenocarcinoma was diagnosed.
  • Primary biliary cystic neoplasm was difficult to diagnose and the management of both benign and malignant tumors was similar in the 5 patients.
  • [MeSH-major] Cystadenocarcinoma / pathology. Cysts / surgery. Incidental Findings. Liver Diseases / surgery. Liver Neoplasms / pathology

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  • (PMID = 16109538.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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24. Mann CM, Bramhall SR, Buckels JA, Taniere P: An unusual case of duodenal obstruction-gangliocytic paraganglioma. J Hepatobiliary Pancreat Surg; 2009;16(4):562-5
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  • Gangliocytic paragangliomas are rare tumors located in the gastrointestinal tract that are considered to be benign.
  • [MeSH-minor] Adolescent. Endoscopy, Digestive System. Female. Humans. Lymph Nodes / pathology. Neoplasm Invasiveness. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 19517054.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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25. Vander Borght S, Libbrecht L, Blokzijl H, Faber KN, Moshage H, Aerts R, Van Steenbergen W, Jansen PL, Desmet VJ, Roskams TA: Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liver. J Pathol; 2005 Dec;207(4):471-82
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  • [Title] Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liver.
  • Hepatocellular adenoma and focal nodular hyperplasia (FNH) are benign liver tumours.
  • Although neither type of lesion is connected to the biliary tree, FNHs are cholestatic, whereas this is rarely the case for hepatocellular adenomas.
  • This suggests that hepatocellular uptake and secretion of bile constituents is different in FNHs compared to adenomas.
  • We therefore evaluated the expression and localization of hepatic transporters in hepatocellular adenomas, different types of FNH and well- to moderately differentiated hepatocellular carcinomas in non-cirrhotic liver and compared them with normal liver, using real-time RT-PCR and (semi-)quantitative immunohistochemistry.
  • We observed diffuse parenchymal expression of the basolateral export pump MRP3 in adenomas, while only reactive bile ductules and adjacent cholestatic hepatocytes were MRP3-positive in FNH.
  • The finding that each type of focal lesion in non-cirrhotic liver has a specific transporter expression pattern may be useful in the establishment of a correct diagnosis by imaging or on needle biopsy.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Liver Neoplasms / diagnosis. Membrane Transport Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adult. Carcinoma, Hepatocellular / diagnosis. Diagnosis, Differential. Female. Focal Nodular Hyperplasia / diagnosis. Gene Expression. Humans. Immunoenzyme Techniques. Liver / metabolism. Male. Middle Aged. Multidrug Resistance-Associated Proteins / metabolism. Organic Anion Transport Polypeptide C / metabolism. Organic Anion Transporters, Sodium-Independent / metabolism. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland.
  • (PMID = 16161006.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Transport Proteins; 0 / Multidrug Resistance-Associated Proteins; 0 / Neoplasm Proteins; 0 / Organic Anion Transport Polypeptide C; 0 / Organic Anion Transporters, Sodium-Independent; 0 / RNA, Neoplasm; 0 / SLCO1B3 protein, human; 0 / multidrug resistance-associated protein 3
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26. Lazaridis KN, Gores GJ: Primary sclerosing cholangitis and cholangiocarcinoma. Semin Liver Dis; 2006 Feb;26(1):42-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary sclerosing cholangitis (PSC), a cholestatic liver disease characterized by fibrosing inflammatory damage of the biliary tree, is a risk factor for cholangiocarcinoma (CCA).
  • Early diagnosis of CCA in PSC is delayed because its clinical presentation can mimic benign dominant biliary strictures.
  • Moreover, biliary and serum tests to diagnose development of CCA in PSC are limiting, although the use of advanced cytologic techniques for aneuploidy and chromosomal aberrations are promising in this regard.
  • As a result, current therapies do not extend survival with the exception of protocol liver transplantation available to a selected group of patients.
  • Future studies should emphasize deciphering the sequence of events that transform the inflammatory changes of the biliary tree to cancer.
  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / complications. Cholangitis, Sclerosing / complications
  • [MeSH-minor] Epidemiologic Studies. Humans. Incidence. Neoplasm Staging. Precancerous Conditions. Risk Factors

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  • (PMID = 16496232.001).
  • [ISSN] 0272-8087
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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27. Nanashima A, Takeshita H, Tobinaga S, Araki M, Sumida Y, Kunizaki M, Tanaka K, Abo T, Hidaka S, Sawai T, Yasutake T, Nagayasu T: Measurement of serum marker for bone metastasis (1-CTP) in hepatobiliary and pancreas malignancies. Hepatogastroenterology; 2010 Jul-Aug;57(101):694-7
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  • To clarify the significance of 1CTP in hepato-biliary pancreas malignancies, we examined the relationship between clinicopathological features and serum level of 1CTP.
  • METHODOLOGY: The subjects were 75 patients who underwent surgical resections including 27 patients with liver carcinomas, 15 with extra-hepatic biliary carcinomas, 14 pancreatic carcinomas and 19 benign diseases.
  • RESULTS: 1CTP level tended to be higher in the malignant diseases than in benign diseases but this difference was not significant (p = 0.065).
  • Compared to benign adenoma, 1CTP level in the malignant diseases was significantly higher (p = 0.049).
  • 1CTP level tended to be higher in patients with cholangitis compared to those with no inflammation or benign tumors (p = 0.065).
  • [MeSH-major] Biliary Tract Neoplasms / pathology. Biomarkers / blood. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Collagen Type I / blood. Liver Neoplasms / pathology. Pancreatic Neoplasms / pathology. Peptides / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholangitis / blood. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 21033212.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Collagen Type I; 0 / Peptides; 0 / collagen type I trimeric cross-linked peptide
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28. Hori T, Wagata T, Takemoto K, Shigeta T, Takuwa H, Hata K, Uemoto S, Yokoo N: Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. World J Gastroenterol; 2008 Oct 14;14(38):5933-7
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  • Magnetic resonance imaging showed a mass in the fundus with a slightly low intensity on T1-weighted images and a slightly high intensity on T2-weighted images.
  • We were agonized in making the qualitative diagnosis of mass-like lesions of the fundus, such as a benign tumor, cancer, or debris.
  • Amylase levels in the common bile duct and gallbladder were quite high.
  • Thus, we diagnosed it as a gallbladder cancer, based on histopathological analysis of the resected specimen.
  • We therefore undertook radical surgery, including wedge resection of the liver, radical dissection of regional lymph nodes, and resection of the extrahepatic bile duct.
  • [MeSH-major] Adenocarcinoma / pathology. Biliary Tract / abnormalities. Gallbladder Neoplasms / pathology. Incidental Findings. Pancreas / abnormalities
  • [MeSH-minor] Aged. Cholangiography. Cholecystectomy, Laparoscopic. Cholecystitis, Acute / surgery. Fatal Outcome. Gallstones / surgery. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Male. Necrosis. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 18855999.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2751910
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29. Buell JF, Thomas MT, Rudich S, Marvin M, Nagubandi R, Ravindra KV, Brock G, McMasters KM: Experience with more than 500 minimally invasive hepatic procedures. Ann Surg; 2008 Sep;248(3):475-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY BACKGROUND DATA: Recent data have confirmed the safety and efficacy of minimally invasive liver surgery.
  • Despite these reports, no programmatic approach to minimally invasive liver surgery has been proposed.
  • The representative tumor histologies were: hepatocellular carcinoma (HCC; N = 210), colorectal carcinoma (N = 40), miscellaneous liver metastases (N = 42), biliary cancer (N = 20), and benign tumors (N = 176).
  • [MeSH-major] Hepatectomy / statistics & numerical data. Liver Neoplasms / surgery. Minimally Invasive Surgical Procedures / statistics & numerical data
  • [MeSH-minor] Catheter Ablation / statistics & numerical data. Humans. Laparoscopy / statistics & numerical data. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Ultrasonography / statistics & numerical data

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  • [CommentIn] Ann Surg. 2009 Jun;249(6):1064-5; author reply 1065-6 [19474661.001]
  • (PMID = 18791368.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Guo KJ, Song SW, Zhao MF, Ge CL, Xu YH, Ma G, Meng FB, Guo RX, Tian YL: [Indications, technique and efficacy of organ preserving pancreatectomy]. Zhonghua Wai Ke Za Zhi; 2010 Sep 15;48(18):1375-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To discuss the proper surgical management of pancreatic benign and low-grade malignant potential neoplasm.
  • RESULTS: Pancreatic fistula and biliary fistula in 1 case respectively were cured among who accepted duodenum-preserving resection of the head of the pancreas.
  • Pancreatic fistula was found in 5 cases among who accepted tumor extirpation of huge pancreatic cancer in pancreatic head and body, and liver metastasis was found in 3 cases at 6, 12, 16 months after surgery respectively.
  • CONCLUSIONS: Organ preserving pancreatectomy can obviously reduce operative injury to patients, its therapeutic effect is similar to that of classical operation, it is the first option of benign and low-grade malignant potential neoplasm.

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  • (PMID = 21092570.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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31. Hwang HS, Kim SH, Jeon TY, Choi D, Lee WJ, Lim HK: Hypointense hepatic lesions depicted on gadobenate dimeglumine-enhanced three-hour delayed hepatobiliary-phase MR imaging: differentiation between benignancy and malignancy. Korean J Radiol; 2009 May-Jun;10(3):294-302
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  • Focal lesions with no functioning hepatocytes, where hepatobiliary metabolism is blocked or inhibited, are generally unable to uptake and excrete gadobenate dimeglumine into the bile.
  • Such lesions are typically malignant and usually appear hypointense as compared to the normal liver parenchyma as seen on hepatobiliary-phase imaging.
  • However, various benign hepatic lesions may also be hypointense due to (a) the presence of no functioning hepatocytes, (b) damage to the functioning hepatocytes or (c) impairment of biliary function as depicted on hepatobiliary-phase imaging.
  • All of these imaging features may result in recognition of the benign hepatic lesions as hepatic malignancies.
  • As depicted on three-hour delayed hepatobiliary-phase imaging, peripheral iso/hyperintensity due to fibrotic tissue compared to the hypointense center with a fuzzy margin may be a clue for the presence of a benign hepatic lesion.
  • In contrast, peripheral hypointensity due to rich tumoral cellularity compared to the center with a clear margin may favor an indication of the presence of a malignant hepatic lesion.
  • [MeSH-major] Contrast Media. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Magnetic Resonance Imaging / methods. Meglumine / analogs & derivatives. Organometallic Compounds
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Image Enhancement / methods. Liver / pathology. Liver Diseases / diagnosis. Liver Diseases / pathology. Male. Middle Aged. Time

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  • (PMID = 19412518.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine
  • [Number-of-references] 30
  • [Other-IDs] NLM/ PMC2672185
  • [Keywords] NOTNLM ; Diagnosis / Gadobenate dimeglumine / Liver neoplasm / Magnetic resonance (MR)
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32. Yamaguchi K, Kaku T, Enjoji M, Kato M, Anai M, Kawakita M, Hamasaki N, Tanaka M: [Urine diacetylspermine as a novel tumor marker]. Rinsho Byori; 2005 Feb;53(2):130-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Urine diacetylspermine as a novel tumor marker].
  • A urine tumor marker, diacetylspermine, was examined in patients with recurrent pancreato-biliary carcinoma, liver tumor, lung carcinoma and gynecologic malignancies.
  • The sensitivity for ovarian carcinoma was 100%, while that for benign ovarian tumor was 0%.
  • [MeSH-major] Biliary Tract Neoplasms / diagnosis. Biomarkers, Tumor / urine. Genital Neoplasms, Female / diagnosis. Liver Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Pancreatic Neoplasms / diagnosis. Spermine / analogs & derivatives. Spermine / urine

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  • (PMID = 15796046.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 2FZ7Y3VOQX / Spermine; 77928-71-3 / N',N''-diacetylspermine
  • [Number-of-references] 6
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33. Uenishi T, Yamazaki O, Tanaka H, Takemura S, Yamamoto T, Tanaka S, Nishiguchi S, Kubo S: Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma. Ann Surg Oncol; 2008 Feb;15(2):583-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma.
  • RESULTS: Analysis of the areas under the receiver operator characteristic (ROC) curves clearly showed better discrimination between intrahepatic cholangiocarcinoma and benign liver diseases for CYFRA 21-1 than for CEA or CA 19-9.
  • On multivariate analysis, a high concentration of CYFRA21-1, nodal metastases, and a microscopic resection margin involvement were independent prognostic factors associated with both tumor recurrence and postoperative death.
  • [MeSH-major] Antigens, Neoplasm / blood. Bile Duct Neoplasms / blood. Bile Ducts, Intrahepatic. Biomarkers, Tumor / blood. Cholangiocarcinoma / blood. Keratins / blood
  • [MeSH-minor] Aged. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Disease-Free Survival. Female. Humans. Keratin-19. Lymphatic Metastasis. Male. Multivariate Analysis. Neoplasm Invasiveness. Prognosis. ROC Curve. Sensitivity and Specificity

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  • (PMID = 17955299.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / antigen CYFRA21.1; 68238-35-7 / Keratins
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