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Items 1 to 53 of about 53
1. Lim KJ, Moon JH, Yoon DY, Cha JH, Lee IJ, Min SJ: Angiomyofibroblastoma arising from the posterior perivesical space: a case report with MR findings. Korean J Radiol; 2008 Jul-Aug;9(4):382-5
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  • Angiomyofibroblastoma is a rare benign soft tissue neoplasm that predominantly occurs in the genital region of middle-aged women.
  • [MeSH-minor] Female. Humans. Middle Aged

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  • [Cites] J Clin Pathol. 2000 Oct;53(10):803 [11064681.001]
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  • (PMID = 18682679.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627271
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2. Booth SJ, Pickles MD, Turnbull LW: In vivo magnetic resonance spectroscopy of gynaecological tumours at 3.0 Tesla. BJOG; 2009 Jan;116(2):300-3
Hazardous Substances Data Bank. CHOLINE CHLORIDE .

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  • Published data for gynaecological lesions are limited and are largely based on MRS carried out at the lower magnetic field strength of 1.5 Tesla (T).
  • OBJECTIVE: The purpose of this study was to determine whether in vivo proton MRS could be performed at the higher magnetic field strength of 3 T to characterise the spectra of a variety of benign and malignant gynaecological lesions.
  • METHODS: We carried out MRS on nonrandomised women undergoing routine 3 T MRI within our MRI department during investigation for gynaecological lesions from February 2006 to April 2008.
  • There was no statistical significant difference between choline levels in various lesion types (P=0.735) or between benign and malignant disease (P=0.550).
  • [MeSH-major] Biomarkers, Tumor / analysis. Choline / analysis. Genital Neoplasms, Female / chemistry. Magnetic Resonance Spectroscopy / methods. Neoplasm Recurrence, Local / chemistry. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Female. Humans. Lipids / analysis. Ovarian Neoplasms / chemistry. Ovarian Neoplasms / diagnosis. Prospective Studies. Sensitivity and Specificity. Uterine Cervical Neoplasms / chemistry. Uterine Cervical Neoplasms / diagnosis. Uterine Neoplasms / chemistry. Uterine Neoplasms / diagnosis. Vulvar Neoplasms / chemistry. Vulvar Neoplasms / diagnosis

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  • (PMID = 19076962.001).
  • [ISSN] 1471-0528
  • [Journal-full-title] BJOG : an international journal of obstetrics and gynaecology
  • [ISO-abbreviation] BJOG
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Lipids; N91BDP6H0X / Choline
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3. Tesfaye A, Di Cello F, Hillion J, Ronnett BM, Elbahloul O, Ashfaq R, Dhara S, Prochownik E, Tworkoski K, Reeves R, Roden R, Ellenson LH, Huso DL, Resar LM: The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. Cancer Res; 2007 May 1;67(9):3998-4004
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

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  • Uterine cancer is the most common cancer of the female genital tract and is the fourth most frequent cause of cancer death in women in the U.S.
  • We generated transgenic mice with high-mobility group A1 gene (HMGA1a) expression targeted to uterine tissue and all female mice developed tumors by 9 months of age.
  • To determine whether these findings are relevant to human disease, we evaluated primary human uterine neoplasms and found that HMGA1a mRNA and protein levels are increased in most high-grade neoplasms but not in normal uterine tissue, benign tumors, or most low-grade neoplasms.
  • [MeSH-minor] Animals. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / metabolism. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Infertility, Female / genetics. Mice. Mice, Nude. Mice, Transgenic. Neoplasm Transplantation. Transfection. Up-Regulation

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  • (PMID = 17483309.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA092339; United States / NCI NIH HHS / CA / T32 CA60441
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 124544-67-8 / HMGA1a Protein; EC 1.14.99.1 / Cyclooxygenase 2
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4. Jeda A, Karoń J, Rak M: [The nodule of the small intestine--a rare case of benign metastasizing leiomyoma]. Ginekol Pol; 2009 Sep;80(9):716-9
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  • [Title] [The nodule of the small intestine--a rare case of benign metastasizing leiomyoma].
  • [Transliterated title] Guzek jelita cienkiego--rzadki przypadek mieśniaka przerzutowego (benign metastasizing leiomyoma).
  • The diagnosis of benign metastasizing leiomyoma BML is a casuic case.
  • The term is used to describe a entity of neoplasms characterized by a proliferation of smooth muscle cells with low mitotic index, usually located outside female genital organs.
  • In the world literature there are reports of benign metastasizing leiomyomas in the lungs, skull base and spine, the lymph nodes of the small pelvis and the heart.
  • [MeSH-minor] Aged. Female. Humans. Hysterectomy. Intestine, Small. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 19886249.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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5. Onuma K, Dabbs DJ, Bhargava R: Mammaglobin expression in the female genital tract: immunohistochemical analysis in benign and neoplastic endocervix and endometrium. Int J Gynecol Pathol; 2008 Jul;27(3):418-25
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  • [Title] Mammaglobin expression in the female genital tract: immunohistochemical analysis in benign and neoplastic endocervix and endometrium.
  • Mammaglobin (MGB), a secretory protein belonging to the uteroglobin/Clara cell protein family, is a sensitive marker for breast carcinoma, but is also reported to be expressed in the female genital tract and its neoplasms.
  • Details of MGB expression pattern and its pathologic significance in the female genital tract have not been systematically studied.
  • Endocervical adenocarcinoma in situ (AIS) showed either weak (predominantly) or moderate (occasionally) expression in about 40% of the cases in comparison with strong positivity in benign endocervical glandular epithelium.
  • Reduction of MGB staining was seen in transition from benign epithelium to AIS.
  • Most endocervical adenocarcinomas are negative for MGB, in contrast to mostly positive endometrioid endometrial adenocarcinomas, however, MGB expression alone is not specific enough to distinguish these 2 tumor types.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / biosynthesis. Carcinoma in Situ / metabolism. Neoplasm Proteins / biosynthesis. Uterine Neoplasms / metabolism. Uteroglobin / biosynthesis. Uterus / metabolism
  • [MeSH-minor] Cervix Uteri / metabolism. Endometrial Neoplasms / metabolism. Endometrium / metabolism. Female. Humans. Immunohistochemistry. Mammaglobin A. Uterine Cervical Neoplasms / metabolism

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  • (PMID = 18580321.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mammaglobin A; 0 / Neoplasm Proteins; 0 / SCGB2A2 protein, human; 9060-09-7 / Uteroglobin
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6. Chatterjee M, Mohapatra S, Ionan A, Bawa G, Ali-Fehmi R, Wang X, Nowak J, Ye B, Nahhas FA, Lu K, Witkin SS, Fishman D, Munkarah A, Morris R, Levin NK, Shirley NN, Tromp G, Abrams J, Draghici S, Tainsky MA: Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays. Cancer Res; 2006 Jan 15;66(2):1181-90
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  • This study used a combination of high-throughput selection and array-based serologic detection of many antigens indicative of the presence of cancer, thereby using the immune system as a biosensor.
  • Protein macroarrays containing 480 of these selected antigen clones revealed 65 clones that interacted with immunoglobulins in sera from 32 ovarian cancer patients but not with sera from 25 healthy women or 14 patients having other benign or malignant gynecologic diseases.

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  • (PMID = 16424057.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R21 CA100740; United States / NCI NIH HHS / CA / CA022453-24; United States / NHGRI NIH HHS / HG / HG003491-01A1; United States / NHGRI NIH HHS / HG / R01 HG003491-01A1; United States / NINDS NIH HHS / NS / NS045207-01; United States / NCI NIH HHS / CA / CA 100740; United States / NINDS NIH HHS / NS / R01 NS045207-01; United States / NCI NIH HHS / CA / CA100740-01; United States / NINDS NIH HHS / NS / R01 NS045207; United States / NCI NIH HHS / CA / P30 CA022453; United States / NHGRI NIH HHS / HG / 1R01 HG 003491-01; United States / NHGRI NIH HHS / HG / R01 HG003491; United States / NINDS NIH HHS / NS / 1R01 NS 045207-01; United States / NCI NIH HHS / CA / P30 CA022453-24; United States / NCI NIH HHS / CA / P30 CA 022453; United States / NCI NIH HHS / CA / R21 CA100740-01; United States / NCI NIH HHS / CA / R33 CA100740
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Peptide Library
  • [Other-IDs] NLM/ NIHMS48954; NLM/ PMC2546578
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7. Canis M, Farina M, Jardon K, Rabischong B, Rivoire C, Nohuz E, Botchorishvili R, Pouly JL, Mage G: [Laparoscopy and gynecologic cancer in 2005]. J Gynecol Obstet Biol Reprod (Paris); 2006 Apr;35(2):117-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Animal studies suggested that the risk of tumor dissemination in non traumatized peritoneum is higher after a pneumoperitoneum than after a laparotomy.
  • Changing these parameters we may, in the future, be able to create a peritoneal environment adapted to oncologic patients in order to prevent or to decrease the risks of peritoneal dissemination and/or of postoperative tumor growth.
  • In contrast restaging of an early ovarian cancer initially managed as a benign mass, is a good indication of the laparoscopic approach.
  • [MeSH-major] Genital Neoplasms, Female / surgery. Laparoscopy
  • [MeSH-minor] Animals. Endometrial Neoplasms / pathology. Endometrial Neoplasms / surgery. Female. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Staging. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Peritoneal Neoplasms / epidemiology. Peritoneal Neoplasms / etiology. Pneumoperitoneum, Artificial / adverse effects. Risk Factors. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / surgery

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  • (PMID = 16575358.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 190
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8. Kalyani R, Das S: Adenomatatoid tumor: Cytological diagnosis of two cases. J Cytol; 2009 Jan;26(1):30-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatatoid tumor: Cytological diagnosis of two cases.
  • Adenomatoid tumor is a benign neoplasm of mesothelial cell origin that occurs in both male and female genital tracts.
  • Fine needle aspiration cytology has an important role in the preoperative diagnosis of the male genital adenomatoid tumor and is a rapid, reliable, conclusive, and cost-effective diagnostic tool that can be used to take appropriate surgical decisions.

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  • (PMID = 21938146.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3167987
  • [Keywords] NOTNLM ; Adenomatoid tumor / FNAC / epididymis / testis
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9. Esheba GE, Longacre TA, Atkins KA, Higgins JP: Expression of the urothelial differentiation markers GATA3 and placental S100 (S100P) in female genital tract transitional cell proliferations. Am J Surg Pathol; 2009 Mar;33(3):347-53
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  • [Title] Expression of the urothelial differentiation markers GATA3 and placental S100 (S100P) in female genital tract transitional cell proliferations.
  • The degree of urothelial differentiation in putative transitional (urothelial) proliferations in the female genital tract is still controversial.
  • To further investigate the similarities (or dissimilarities) between female genital tract transitional proliferations and bladder urothelium, we evaluated the expression of S100P and GATA3, 2 proteins that we previously found to be strongly expressed in bladder urothelial tumors, in 25 benign ovarian Brenner tumors, 19 Walthard cell nests (17 tubal and 2 ovarian hilus), 1 mature teratoma with a benign urothelial proliferation, 2 proliferating (borderline) ovarian Brenner tumors, 1 malignant Brenner tumor, and 12 ovarian transitional cell carcinomas (TCC).
  • One of 2 proliferating Brenner tumors was positive for S100P, whereas both cases were positive for GATA3 and p63; the malignant Brenner tumor was positive for S100P and p63, but negative for GATA3.
  • The teratoma-associated benign urothelial proliferation was also negative for S100P, but positive for GATA3 and p63.
  • [MeSH-major] Biomarkers, Tumor / analysis. Calcium-Binding Proteins / biosynthesis. Carcinoma, Transitional Cell / metabolism. GATA3 Transcription Factor / biosynthesis. Genital Neoplasms, Female / metabolism. Neoplasm Proteins / biosynthesis
  • [MeSH-minor] Cell Differentiation. Female. Humans. Immunohistochemistry. Membrane Proteins / biosynthesis. Tissue Array Analysis. Urothelium / metabolism

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  • (PMID = 19092634.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / GATA3 Transcription Factor; 0 / GATA3 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / S100P protein, human
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10. Heatley MK: Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature. Pathology; 2009;41(7):645-8

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  • [Title] Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature.
  • AIMS: To establish the prognosis associated with female adnexal tumour of probable wolffian origin (FATWO) and determine the frequency with which it behaves as a truly benign lesion.
  • One patient with a ruptured tumour had recurrent disease and one other had died of disease (p = 0.2278).
  • CONCLUSION: On the basis of these findings, FATWO cannot be regarded as a benign lesion.
  • [MeSH-major] Adnexa Uteri / pathology. Genital Neoplasms, Female / pathology. Wolffian Ducts / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Databases, Bibliographic. Disease-Free Survival. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 20001344.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 48
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11. Schem Ch, Bauerschlag DO, Meinhold-Heerlein I, Fischer D, Friedrich M, Maass N: [Benign and borderline tumors of the ovary]. Ther Umsch; 2007 Jul;64(7):369-74
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  • [Title] [Benign and borderline tumors of the ovary].
  • [Transliterated title] Benigne und Borderline-Tumoren des Ovars.
  • The suspected diagnosis concerning benign or malignant lesions, should take the palpable and sonographic feature, as well as the information from the patients medical history (e.g. family history of malignant diseases (BRCA 1/2 mutations) into account.
  • In this regard, there are no other additional parameters established.
  • They are mostly normal follicle cysts, but may also be a tumor of low malignant potential (LMP-tumor) or even an invasive cancerous lesion.
  • Benign or malignant lesions may occur in every age group.
  • Malignant ovarian lesions represent about 15-30% of all genital malignant tumors.
  • This compilation overviews the spectrum of benign and low malignant potential tumors of the ovary and their different tissues of origin.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Ovarian Cysts / diagnosis. Ovarian Cysts / radiography. Ovarian Cysts / ultrasonography. Ovary / pathology. Palpation. Time Factors. Tomography, X-Ray Computed. Ultrasonography, Doppler

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  • (PMID = 17948753.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 22
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12. Seidman JD, Kumar D, Cosin JA, Winter WE 3rd, Cargill C, Boice CR: Carcinomas of the female genital tract occurring after pelvic irradiation: a report of 15 cases. Int J Gynecol Pathol; 2006 Jul;25(3):293-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinomas of the female genital tract occurring after pelvic irradiation: a report of 15 cases.
  • Ten were irradiated for cervical cancer, one for endometrial carcinoma, one for vulvar carcinoma, one for colon cancer and 2 for benign conditions.
  • [MeSH-major] Carcinoma / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Radiation-Induced / pathology. Pelvis / radiation effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / pathology. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 16810069.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. McCluggage WG, Boyde A: Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant. Int J Surg Pathol; 2007 Jul;15(3):262-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant.
  • We believe angioleiomyoma should be recognized as a distinct entity and included in the World Health Organization classification of tumors of the female genital tract as a benign leiomyoma variant, similar to cellular and atypical leiomyoma.
  • Uterine angioleiomyoma has a close morphological resemblance to the similarly named skin tumor.
  • We review uterine smooth-muscle and other mesenchymal neoplasms in which prominent vascular channels are a feature.
  • [MeSH-minor] Actins / genetics. Actins / metabolism. Adult. Antigens, Neoplasm. Calmodulin-Binding Proteins / genetics. Calmodulin-Binding Proteins / metabolism. Desmin / genetics. Desmin / metabolism. Female. Gene Expression Regulation, Neoplastic. Humans. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism

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  • (PMID = 17652533.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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14. Chalas E, Costantino JP, Wickerham DL, Wolmark N, Lewis GC, Bergman C, Runowicz CD: Benign gynecologic conditions among participants in the Breast Cancer Prevention Trial. Am J Obstet Gynecol; 2005 Apr;192(4):1230-7; discussion 1237-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign gynecologic conditions among participants in the Breast Cancer Prevention Trial.
  • OBJECTIVE: This study was undertaken to report on the benign gynecologic conditions occurring among women with an intact uterus at enrollment in the Breast Cancer Prevention Trial of the National Surgical Adjuvant Breast and Bowel Project.
  • STUDY DESIGN: The incidence rates of several benign gynecologic conditions were determined and risks were compared among women receiving tamoxifen and those receiving placebo, based on risk ratios (RRs) with 95% CIs.
  • [MeSH-major] Antineoplastic Agents, Hormonal / adverse effects. Breast Neoplasms / therapy. Genital Diseases, Female / chemically induced. Genital Diseases, Female / pathology. Neoplasm Recurrence, Local / prevention & control. Tamoxifen / adverse effects
  • [MeSH-minor] Adult. Age Distribution. Aged. Chemotherapy, Adjuvant. Confidence Intervals. Dose-Response Relationship, Drug. Female. Humans. Incidence. Middle Aged. Neoplasm Staging. Probability. Reference Values. Risk Assessment

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  • [CommentIn] Am J Obstet Gynecol. 2006 Apr;194(4):1204-5; author reply 1205 [16580343.001]
  • (PMID = 15846210.001).
  • [ISSN] 0002-9378
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U10-CA-37377; United States / NCI NIH HHS / CA / U10-CA-69974
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen
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15. Balasenthil S, Broaddus RR, Kumar R: Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas. Hum Pathol; 2006 Jun;37(6):656-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas.
  • Endometrial carcinoma is one of the most common malignancies of the female genital tract.
  • We investigated the expression profile of MTA1 in different stages of benign endometrium as well as in endometrial endometrioid adenocarcinoma using immunohistochemistry and Western blotting.
  • Western blot analysis of 6 tumor specimens showed increased expression of MTA1 in all the tumors analyzed.
  • Immunohistochemical staining performed on tumor microarray containing 70 endometrial endometrioid adenocarcinomas of various grades showed increased expression of MTA1 in 53 (75.7%) tumors.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Cell Nucleus / metabolism. Cytoplasm / metabolism. Female. Humans. Immunohistochemistry. Neoplasm Staging

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  • (PMID = 16733204.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 098823
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Repressor Proteins; EC 3.5.1.- / Mta1 protein, human; EC 3.5.1.98 / Histone Deacetylases
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16. Whittaker CS, Coady A, Culver L, Rustin G, Padwick M, Padhani AR: Diffusion-weighted MR imaging of female pelvic tumors: a pictorial review. Radiographics; 2009 May-Jun;29(3):759-74; discussion 774-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion-weighted MR imaging of female pelvic tumors: a pictorial review.
  • Diffusion-weighted MR imaging studies of female pelvic tumors have shown reduced apparent diffusion coefficient (ADC) values within cervical and endometrial tumors.
  • In addition, this unique noninvasive modality has demonstrated the capacity to help discriminate between benign and malignant uterine lesions and to help assess the extent of peritoneal spread from gynecologic malignancies.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Genital Neoplasms, Female / pathology. Pelvic Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Endometrial Neoplasms / pathology. Female. Humans. Leiomyoma / pathology. Lymphatic Metastasis. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 19448114.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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17. Akhvlediani L, Nagervadze M, Dumbadze G: Detection of tolerance against human chorionic gonadotropin at malignant and benign tumors of female reproduction system. Georgian Med News; 2009 Jun;(171):20-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of tolerance against human chorionic gonadotropin at malignant and benign tumors of female reproduction system.
  • The main aim of this study was to investigate the possibility of hCG synthesis during malignant gynecological tumors and establish the level of tolerance against hCG in malignant and benign tumors.
  • We have examined peripheral blood of 86 patients with malignant and benign tumors of reproductive system and healthy donors, aged 42-65 for detection of anti-hCG auto-antibodies and possibility of hCG synthesis.
  • Investigation have shown that in case of malignant tumors as auto-antibody concentration is low and hCG level is high, hCG plays a role of autocrine growth factor for tumor cells and maintains the malignancy and tumor growth.
  • The existence of auto-antibody indicates that immune system is not completely tolerant to hCG.
  • During studies on the effectiveness of anti-tumor vaccine, this fact should be taken into consideration.
  • [MeSH-major] Antibodies, Neoplasm / immunology. Chorionic Gonadotropin / immunology. Genital Neoplasms, Female / immunology. Genital Neoplasms, Female / pathology
  • [MeSH-minor] Adult. Female. Humans. Middle Aged

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  • (PMID = 19578206.001).
  • [ISSN] 1512-0112
  • [Journal-full-title] Georgian medical news
  • [ISO-abbreviation] Georgian Med News
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Georgia (Republic)
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Chorionic Gonadotropin
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18. Harada O, Ota H, Takagi K, Matsuura H, Hidaka E, Nakayama J: Female adnexal tumor of probable wolffian origin: morphological, immunohistochemical, and ultrastructural study with c-kit gene analysis. Pathol Int; 2006 Feb;56(2):95-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Female adnexal tumor of probable wolffian origin: morphological, immunohistochemical, and ultrastructural study with c-kit gene analysis.
  • Female adnexal tumors of probable wolffian origin (FATWO) are rare neoplasms believed to originate from mesonephric (wolffian) remnants.
  • Although most cases follow a benign clinical course, approximately 10% of them either recur or metastasize and are thought to be resistant to chemoradiation therapy.
  • The tumor had typical characteristics of FATWO in both morphology and immunohistochemistry.
  • In addition, the cytological features of this rare tumor are presented, which have not been described previously.
  • [MeSH-major] Adnexa Uteri. Genital Neoplasms, Female / diagnosis. Mesonephros / pathology. Proto-Oncogene Proteins c-kit / genetics
  • [MeSH-minor] Adnexal Diseases / diagnosis. Adnexal Diseases / metabolism. Adnexal Diseases / pathology. DNA, Neoplasm / analysis. DNA, Neoplasm / genetics. Exons / genetics. Female. Humans. Immunohistochemistry. Keratins / analysis. Magnetic Resonance Imaging. Microscopy, Electron. Middle Aged. Mutation. Vimentin / analysis

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  • (PMID = 16445822.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Vimentin; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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19. Grammatikakis I, Ivanov S, Evangelinakis N, Zevoudis S, Tziortzioti V: [Incidence of synchronous primary neoplasms of the female reproductive tract in women with ovarian endometriosis: a retrospective analysis of 811 cases]. Akush Ginekol (Sofiia); 2009;48(3):26-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Incidence of synchronous primary neoplasms of the female reproductive tract in women with ovarian endometriosis: a retrospective analysis of 811 cases].
  • PURPOSE: Although endometriosis is a benign disorder recent studies suggest endometriosis could be viewed as a neoplastic process.
  • RESULTS: 5 women with synchronous cancers of the genital tract were identified.
  • Similarly, 4 out of 5 ovarian cancers were endometrioid, while one was serum cystadenosarcoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bulgaria / epidemiology. Female. Greece / epidemiology. Humans. Incidence. Middle Aged. Neoplasm Staging. Retrospective Studies. Uterine Neoplasms / epidemiology. Uterine Neoplasms / pathology. Young Adult

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  • (PMID = 20198760.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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20. Sargenti-Neto S, Brazão-Silva MT, do Nascimento Souza KC, de Faria PR, Durighetto-Júnior AF, Loyola AM, Cardoso SV: Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions. Br J Oral Maxillofac Surg; 2009 Jan;47(1):62-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions.
  • Granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue that characteristically affects the oral cavity, with increased frequency in the tongue.
  • [MeSH-major] Granular Cell Tumor / pathology. Lip Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Genital Neoplasms, Female / surgery. Humans. Neoplasm Recurrence, Local. Perineum / pathology. Perineum / surgery

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  • (PMID = 18976838.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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21. Sánchez MF, Sánchez JM, Rustrían FV, Ramírez FT, Silva AM: [Intravenous uterine leiomyomatosis with diffuse dissemination in pelvic cavity. Case report and literature review]. Ginecol Obstet Mex; 2008 Aug;76(8):483-6
MedlinePlus Health Information. consumer health - Uterine Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diffuse uterine leiomyomatosis is a rare benign entity in gynecology, with only 30 worldwide reports.
  • We report a case of a 40 years old female with history of pelvic mass resection.
  • This mass extends itself out of pelvis until aorto-abdominal bifurcation, and has gummatous, elastic, and highly bleeding consistency.
  • Histopathologic report was intravenous leiomyomatosis with benign smooth muscular fibers infiltrating adjacent structures.
  • [MeSH-major] Genital Neoplasms, Female / pathology. Leiomyomatosis / pathology. Pelvic Neoplasms / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Veins

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  • (PMID = 18798452.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 8
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22. Perko Z, Durdov MG, Druzijanić N, Kraljević D, Juricić J: Giant perianal angiomyofibroblastoma--a case report. Coll Antropol; 2006 Mar;30(1):243-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 45-year old female had a long history of slow growing perianal tumor at the right side of her anus.
  • This rare benign tumour typically involves vulvovaginal, pelvic and perinal region.
  • It is important to separate this neoplasm from locally invasive aggressive angiomyxoma and low grade fibromyxoid sarcoma, which can arise in the the same localisation.
  • [MeSH-major] Angiomyoma / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Muscle Tissue / pathology
  • [MeSH-minor] Female. Humans. Middle Aged

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  • (PMID = 16617606.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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23. Tsarpalis DC, Giannakopoulos CK, Lagadas AA, Toufexi EG: Aggressive angiomyxoma: case report and review of the literature. Eur J Gynaecol Oncol; 2007;28(6):480-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aggressive angiomyxoma is a rare benign mesenchymal neoplasm, found mainly in the female pelvis and perineum.
  • The tumor is usually misdiagnosed at presentation.
  • Other treatment options include use of hormone antagonists, such as tamoxifen, or GnRH analogs, and selective angiographic embolism.
  • High recurrence rate of the tumor, up to 70% within a 2-year period, makes long-term imaging follow-up of the patient necessary.
  • [MeSH-major] Genital Neoplasms, Female / diagnosis. Myxoma / diagnosis
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 18179141.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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24. Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P, Fogel M: Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum Pathol; 2006 Aug;37(8):1000-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we carried out an immunohistochemical survey of L1 expression in normal adults and in a broad range of benign and malignant tumors using monoclonal antibody L1-11A and the novel monoclonal antibody L1-14.10.
  • In tumors of the female genital tract, L1 was detected in adenocarcinomas of the cervix and fallopian tubes, in addition to ovarian and endometrial carcinomas.
  • Nongynecological tumors expressing L1 comprised malignant melanoma, colon adenocarcinoma positive to chromogranin, clear-cell adenocarcinoma of the urinary bladder, pheochromocytoma, small cell lung carcinoma, and tumors of the nervous system.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Genital Neoplasms, Female / metabolism. Isoantigens / metabolism. Membrane Glycoproteins / metabolism. Receptors, Cell Surface / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / immunology. Cell Line, Tumor. Diagnosis, Differential. Female. Fluorescent Antibody Technique, Direct. GPI-Linked Proteins. Humans. Immunoenzyme Techniques. Male. Neutrophils / metabolism

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  • (PMID = 16867862.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD177 protein, human; 0 / GPI-Linked Proteins; 0 / Isoantigens; 0 / Membrane Glycoproteins; 0 / Receptors, Cell Surface
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25. Turnbull L, Booth S: MR imaging of gynecologic diseases at 3T. Magn Reson Imaging Clin N Am; 2007 Aug;15(3):403-31, vii-viii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • By differentiating benign from malignant disease with very high specificity, it can aid the selection of patients requiring further treatment and determine the level of urgency.
  • [MeSH-major] Genital Diseases, Female / diagnosis. Image Enhancement / methods. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Artifacts. Diagnosis, Differential. Female. Humans. Neoplasm Staging. Neoplasm, Residual. Ovarian Diseases / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 17893060.001).
  • [ISSN] 1064-9689
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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26. Jozwik M, Szajda SD, Skrzydlewski Z, Jozwik M, Sulkowski S: The activity of cancer procoagulant in cases of uterine leiomyomas. Eur J Gynaecol Oncol; 2005;26(4):407-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The present study was designed to test whether it is also synthesized by benign neoplastic cells, namely uterine leiomyomas.
  • MATERIALS AND METHODS: We determined the activity of CP in the blood serum of women with uterine leiomyomas (N = 24), normal women (N = 15), and genital cancer patients (N = 6) by the coagulative method according to Gordon and Benson.
  • RESULTS: The mean CP activity in the sera of women with uterine leiomyomas was 181.1 seconds (s) +/- 19.9 s, in healthy women--293.2 s +/- 33.8 s, and in genital cancer patients--78.8 +/- 18.5 s (all differences: p < 0.001).
  • Similarly, in homogenates of uterine leiomyomas the CP activity was 19.6 +/- 3.8 nmoles pNa/ml, in normal uterine muscle it was 13.2 +/- 2.2 nmoles pNa/ml, and in cancerous tissue--28.0 +/- 6.6 nmol pNa/ml (all values being significantly different from each other).
  • The coagulation time of 120 to 240 s by the Gordon and Benson method supported the diagnosis of uterine leiomyoma, and a value below 120 s--the suspicion of genital cancer.
  • CONCLUSIONS: Uterine leiomyomas, representing benign genital neoplasia, synthesize CP and are the likely origin of CP activity in blood, as has been described for malignant tumors, but to a lesser degree.
  • There may be a role for CP as a tumor marker of genital neoplasia.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cysteine Endopeptidases / biosynthesis. Leiomyoma / diagnosis. Neoplasm Proteins / analysis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Genital Neoplasms, Female / blood. Genital Neoplasms, Female / chemistry. Genital Neoplasms, Female / diagnosis. Humans. Middle Aged. Pilot Projects

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  • (PMID = 16122189.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.26 / cancer procoagulant
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27. Scurry WC Jr, McGinn JD: Recurrent respiratory papillomatosis in pregnancy: a case of emergent airway management. Ear Nose Throat J; 2008 Jun;87(6):E8-11
MedlinePlus Health Information. consumer health - Tumors and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recurrent respiratory papillomatosis is a benign neoplastic process involving squamous epithelium of the respiratory tract, typically the vocal folds.
  • Human papillomavirus (HPV) is known to be the etiologic agent in this disease process, as well as in condyloma acuminata, or genital warts.
  • [MeSH-major] Laryngeal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Papilloma / surgery. Pregnancy Complications, Neoplastic / surgery. Pregnancy Outcome
  • [MeSH-minor] Adult. Airway Obstruction / diagnosis. Airway Obstruction / etiology. Biopsy, Needle. Emergency Treatment. Female. Follow-Up Studies. Humans. Immunohistochemistry. Laryngoscopy. Pregnancy. Risk Assessment. Treatment Outcome

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  • (PMID = 18561109.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Field JB, Benoit MF, Dinh TA, Diaz-Arrastia C: Computer-enhanced robotic surgery in gynecologic oncology. Surg Endosc; 2007 Feb;21(2):244-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 21 patients had benign indications for surgery.
  • [MeSH-major] Genital Neoplasms, Female / surgery. Gynecologic Surgical Procedures / instrumentation. Robotics / methods. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Incidence. Middle Aged. Minimally Invasive Surgical Procedures / instrumentation. Neoplasm Staging. Postoperative Complications / epidemiology. Retrospective Studies. Risk Assessment. Survival Rate. Treatment Outcome

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  • [Cites] Fertil Steril. 2000 May;73(5):1040-2 [10785235.001]
  • [Cites] Surg Endosc. 2002 Sep;16(9):1271-3 [12085153.001]
  • [Cites] Surg Endosc. 2002 Dec;16(12):1790-2 [12239646.001]
  • [Cites] Urologe A. 2002 Mar;41(2):144-9 [11993092.001]
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  • [Cites] Surg Clin North Am. 2001 Aug;81(4):949-64 [11551135.001]
  • (PMID = 17186433.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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29. Hrgović Z, Kulas T, Habek D, Izetbegović S, Hrgović I: [New options in the diagnosis and management of uterine myoma]. Med Arh; 2008;62(4):234-9
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  • Myoma accounts for nearly 95% of all benign tumors of female genital organs and is the most common neoplasm of female genital tract.
  • [MeSH-minor] Female. Humans

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  • (PMID = 19145810.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] bos
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Bosnia and Herzegovina
  • [Number-of-references] 61
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30. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations.
  • The median patient age was 46 years (range, 15-97 years); there was a marked female predominance (22 females, 4 males).
  • Recurrence and/or metastasis was strongly associated tumor size > median size (8 cm), mitotic activity greater than 1/50 HPF, and necrosis.
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • PEComas with nuclear pleomorphism alone ("symplastic") and large PEComas without other worrisome features have uncertain malignant potential.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Connective and Soft Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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31. Khan N, Oriuchi N, Yoshizaki A, Kanuma T, Higuchi T, Endo K: Diagnostic accuracy of FDG PET imaging for the detection of recurrent or metastatic gynecologic cancer. Ann Nucl Med; 2005 Apr;19(2):137-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: This study evaluated the diagnostic role and accuracy of positron emission tomography (PET) using 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) for the detection of tumor foci in patients with suspected recurrent or metastatic lesions of gynecologic cancers.
  • The accuracy of the PET results was assessed by a consensual verdict based on histology, cytology, other imaging and clinical follow-up.
  • Malignant lesions accumulated significantly more FDG than the benign ones (the mean SUVs were 3.7 +/- 1.9 and 1.6 +/- 1.1, respectively, p = 0.004).
  • The sensitivity and specificity in correct identification of tumor recurrence or metastases using a threshold SUV 1.9 were 88.8% and 66.7% in contrast to the visual analysis (sensitivity 96.4%, specificity 50%) on a lesion-based analysis.
  • FDG PET was valuable when CT/MRI was negative or inconclusive, and in patients with elevated tumor marker levels as well as with normal tumor marker levels when recurrence was suspected clinically.
  • However, PET failed to visualize some small metastatic lesions in lung and bone, and showed falsely high FDG uptake in some benign lesions.
  • [MeSH-major] Carcinoma / radionuclide imaging. Carcinoma / secondary. Fluorodeoxyglucose F18. Genital Neoplasms, Female / radionuclide imaging. Genital Neoplasms, Female / secondary. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Radiopharmaceuticals. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 15909494.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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32. Gallardo A, Prat J: Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. Am J Surg Pathol; 2009 Feb;33(2):278-88
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  • Three of the 4 ovarian tumors were stage IA and the other was stage IIIC.
  • The tumor of the fallopian tube was stage IC, and the tumors of the vagina and recto-uterine pouch were confined to their site of origin.
  • Of 4 cervical tumors, 2 were endocervical polyps, 1 invaded one-third of the cervical wall, and the other invaded its full thickness.
  • Six developed metastases and 5 of them died of tumor.
  • Four had adenosarcomas with sarcomatous overgrowth; however, the other 2 patients had typical low-grade adenosarcomas of the uterine corpus and cervix, respectively, exhibiting only mild nuclear atypia of the stromal component and </=2 mitotic figures/10 high power fields.
  • The finding of such cases, which raises the controversy of whether or not adenofibroma exists as a tumor entity, prompted us to make a comparative immunohistochemical analysis of 23 typical adenosarcomas, 8 adenosarcomas with sarcomatous overgrowth, and 29 benign and malignant related lesions, including 7 clinically benign adenofibromas.
  • Adenosarcomas with sarcomatous overgrowth showed strong immunoreaction for Ki-67 and p53 and loss of CD10 and progesterone receptors immunostaining; in contrast, the immunoreaction for these tumor markers in typical adenosarcomas without sarcomatous overgrowth was similar to that of adenofibromas associated with favorable outcome and other benign lesions such as endometrial polyps and endometriosis.
  • [MeSH-major] Adenofibroma / pathology. Adenosarcoma / pathology. Genital Neoplasms, Female / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Middle Aged. Mitotic Index. Neoplasm Staging. Tissue Array Analysis

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  • (PMID = 18941402.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Hameed M, Clarke K, Amer HZ, Mahmet K, Aisner S: Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report. Cancer Genet Cytogenet; 2007 Sep;177(2):131-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular angiofibroma is a benign mesenchymal neoplasm of female and male genital tract composed of prominent vasculature and stromal spindle cells, often with admixture of adipose tissue.
  • The tumor has histomorphologic similarities to angiomyofibroblastoma and spindle cell lipoma.
  • Herein we describe a tumor arising in the perineal region of a 60-year-old man with morphological and immunohistochemical features of cellular angiofibroma and showing cytogenetic characteristics similar to spindle cell lipoma.

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  • (PMID = 17854668.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Ben Hmid R, Mourali M, Zghal D, Mahjoub S, Naceur C, Sbai N, Zouari F: [Usefulness of colposcopy in inflammatory cervico-vaginal smears: apropos of 140 cases]. Tunis Med; 2007 Jun;85(6):500-4
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  • AIM: The purpose of our study is to proove that an inflammatory cervical smear should be considered as a positive test and must lead to other investigations.
  • 68.57% of them are in active genital period.
  • It showed benign lesions such as: ectropion in 22.85%, colpitis in 14.28%, cervical polypus in 5%, normal transformation zone in 8.57%, but also suspicious lesions such as : atypical transformations grade I (ATGI) in 25.71% and atypical transformations grade II (ATGII) in 13.57%.
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Biopsy. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Cervical Intraepithelial Neoplasia / pathology. Female. Humans. Middle Aged. Neoplasm Invasiveness. Polyps / pathology. Prospective Studies. Sexual Behavior. Uterine Cervical Diseases / pathology. Uterine Cervical Dysplasia / pathology. Uterine Cervicitis / pathology. Vaginitis / pathology


35. Fletcher AH, Wilkinson EJ, Knapik JA: Oncogenic human papillomavirus testing in an adolescent population with atypical squamous cells of undetermined significance. J Low Genit Tract Dis; 2009 Jan;13(1):28-32
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  • Of the remaining 258, 127 (49%) were negative(-) for HPV, whereas 131 (51%) were HPV positive(+).In the HPV(-) population (n=127), 3 (2%) patients were referred for colposcopy and had benign findings.
  • Of these 48, 25 had benign colposcopic findings, 12 had cervical intraepithelial neoplasia 1 (CIN 1), and 11 had CIN 2/3.
  • [MeSH-minor] Adolescent. Colposcopy. Female. Humans. Mass Screening. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19098603.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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36. Dai SY, Hata K, Inubashiri E, Kanenishi K, Shiota A, Ohno M, Yamamoto Y, Nishiyama Y, Ohkawa M, Hata T: Does three-dimensional power Doppler ultrasound improve the diagnostic accuracy for the prediction of adnexal malignancy? J Obstet Gynaecol Res; 2008 Jun;34(3):364-70

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  • OBJECTIVE: The aim of the present study was to investigate the diagnostic accuracy of three-dimensional power Doppler ultrasound (3DPD) in the differentiation between benign and malignant adnexal masses and evaluate 3DPD for assessing malignancy in comparison with two-dimensional transvaginal gray-scale sonography (2DTVS), magnetic resonance imaging (MRI) and positron emission tomography (PET).
  • RESULTS: Of the 36 patients, 25 had a malignancy, 5 had a borderline tumor, and 6 had a benign mass.
  • [MeSH-major] Adnexal Diseases / diagnosis. Genital Neoplasms, Female / diagnosis. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Fallopian Tube Neoplasms / diagnosis. Fallopian Tube Neoplasms / pathology. Fallopian Tube Neoplasms / surgery. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Staging. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Sensitivity and Specificity

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  • (PMID = 18686352.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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37. Wiser A, Korach J, Gotlieb WH, Fridman E, Apter S, Ben-Baruch G: Importance of accurate preoperative diagnosis in the management of aggressive angiomyxoma: report of three cases and review of the literature. Abdom Imaging; 2006 May-Jun;31(3):383-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Aggressive angiomyxoma is a benign but locally aggressive tumor that occurs mostly in young women.
  • This report describes differences in presentation and the importance of accurate preoperative diagnosis of this rare neoplasm.
  • [MeSH-major] Genital Neoplasms, Female / diagnosis. Myxoma / diagnosis
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 16317491.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 12
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38. He Y, Yang KX, Yang F, Wu XL: Primary solitary fibrous tumor of the vulva: a case report. J Reprod Med; 2010 Sep-Oct;55(9-10):452-6
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  • [Title] Primary solitary fibrous tumor of the vulva: a case report.
  • BACKGROUND: Solitary fibrous tumor (SFT) of the female genital tract is an extremely rare neoplasm of mesenchymal origin.
  • The tumor presented as a 10-cm, well-circumscribed lump and was composed of bland-looking cells admixed with thin and thick collagen fibers with the appearance of hemangiopericytoma.
  • Microscopic evaluation and immunohistochemistry supported the diagnosis of a primary benign vulvar SFT.
  • The outcome of this tumor is based mostly on complete surgical resection.
  • [MeSH-minor] Adult. Female. Gynecologic Surgical Procedures. Humans

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  • (PMID = 21043376.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Denkert C, Dietel M: Borderline tumors of the ovary and peritoneal implants. Verh Dtsch Ges Pathol; 2005;89:84-91
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  • The new WHO series on Pathology and Genetics of Tumours of the Breast and Female Genital Organs (33) defined to name the group of epithelial ovarian tumors with a dignity between benign and malignant exclusively as Borderline Tumors of the Ovary (BOT) and to skip the term "... of low malignant potential".
  • 80 to 90% of the cases have a very favourable prognosis while 10-20% exhibit a recurrent clinical course with peritoneal implants and very rarely death from the tumor within 10 years.
  • [MeSH-minor] Diagnosis, Differential. Disease-Free Survival. Female. Humans. Meta-Analysis as Topic. Neoplasm Invasiveness. Neoplasm Staging. Survival Analysis

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  • (PMID = 18035677.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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40. De Gaetano AM, Calcagni ML, Rufini V, Valentini AL, Gui B, Giordano A, Bonomo L: Imaging of gynecologic malignancies with FDG PET-CT: case examples, physiologic activity, and pitfalls. Abdom Imaging; 2009 Nov;34(6):696-711
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  • Increased uptake has also been reported in many benign pelvic processes and in premenopausal patients; endometrial activity changes cyclically, whereas increased ovarian uptake may be functional.
  • FDG PET-CT is most suitable in patients with high tumor markers and negative or uncertain conventional imaging data.
  • [MeSH-major] Fluorodeoxyglucose F18. Genital Neoplasms, Female / radiography. Genital Neoplasms, Female / radionuclide imaging. Radiopharmaceuticals. Tomography, Emission-Computed / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Female. Humans. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging. Sensitivity and Specificity. Whole Body Imaging

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  • (PMID = 18791682.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 75
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41. Rufforny I, Wilkinson EJ, Liu C, Zhu H, Buteral M, Massoll NA: Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma. J Low Genit Tract Dis; 2005 Apr;9(2):108-13
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  • METHODS: A total of 49 vulvar biopsy samples were examined by hematoxylin-eosin staining from benign/reactive lesions, condyloma acuminatum, VIN, and invasive squamous cell carcinoma (SCC).
  • No p16(INK4a) immunoreactivity was observed in any of the benign/reactive and condyloma acuminatum lesions.
  • In addition, none of the benign/reactive or condyloma lesions were positive for HPV type 16 by RT-PCR analysis.
  • CONCLUSIONS: Upregulation of INK4a gene occurs in vulvar carcinogenesis. p16(INK4a) is not a sensitive marker for differentiation of benign vulvar squamous epithelium from condyloma acuminatum or VIN 1 lesions because most VIN 1 lesions are p16(INK4a) negative.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Papillomavirus Infections / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. DNA, Viral / genetics. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness. Papillomaviridae / genetics. Polymerase Chain Reaction. Vulva / chemistry. Vulva / pathology. Vulva / virology

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  • (PMID = 15870532.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral
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42. Hollowell ML, Goulart RA, Gang DL, Otis CN, Prior J, Sachs BF, Pantanowitz L: Cytologic features of müllerian papilloma of the cervix: mimic of malignancy. Diagn Cytopathol; 2007 Sep;35(9):607-11
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  • Müllerian papilloma is a rare benign tumor of the cervix and/or vagina that occurs predominantly in young children.
  • The cytologic features of benign müllerian papilloma have never been described.
  • We report for the first time, to our knowledge, the cytologic findings of a benign müllerian papilloma from the vaginal fluid specimen of a 15-mo-old girl using touch prep, ThinPrep, and cell block preparations.
  • The deceptive cytologic features of a cellular specimen with complex papillary fronds composed of overlapping and crowded small hyperchromatic cells, with a high nuclear:cytoplasmic ratio, and feathering in this case resembled a malignant neoplasm.
  • The clinical findings and cytomorphology of a benign müllerian papilloma can mimic those of malignant lesions of the female lower genital tract such as sarcoma botryoides and adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Diagnosis, Differential. Female. Humans. Infant. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / pathology


43. Piura B, Rabinovich A, Sinelnikov I, Delgado B: Tailgut cyst initially misdiagnosed as ovarian tumor. Arch Gynecol Obstet; 2005 Oct;272(4):301-3
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  • [Title] Tailgut cyst initially misdiagnosed as ovarian tumor.
  • It is usually benign and located in the retrorectal/presacral space.
  • The initial diagnosis was neoplasm of the right ovary.
  • At laparotomy, the mass was lying free from apparently normal internal genital organs.
  • [MeSH-minor] Diagnosis, Differential. Female. Histocytochemistry. Humans. Hysterectomy. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16041543.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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44. Dietz NK, Rehn M, Thanner F, Dietl J: [Diagnostic and preoperative staging of endometrial carcinoma with transvaginal sonography--a review]. Zentralbl Gynakol; 2006 Oct;128(5):246-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Endometrial carcinoma is the most common malignant tumor of the female genital tract.
  • Measuring the fluid within the uterine cavity does not seem to be useful in differentiating malignant from benign disorders.
  • The extent of surgery depends on the preoperative estimation of the tumor stage which is particularly important for elder patients with increased morbidity.
  • Although promising studies exist, additional examinations have to be done in order to determine the role of transvaginal sonography beside other methods (CT, MRT).
  • [MeSH-major] Endometrial Neoplasms / pathology. Endometrial Neoplasms / surgery. Neoplasm Staging / methods. Ultrasonography / methods
  • [MeSH-minor] Female. Humans

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  • (PMID = 17001559.001).
  • [ISSN] 0044-4197
  • [Journal-full-title] Zentralblatt für Gynäkologie
  • [ISO-abbreviation] Zentralbl Gynakol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 93
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45. Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP: A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol; 2007 Jan;211(1):26-35
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  • We recently identified foci of strong p53 immunostaining-termed 'p53 signatures'-in benign tubal mucosa from BRCA+ women.
  • This is the first report of an early and distinct alteration in non-neoplastic upper genital tract mucosa that fulfils many requirements for a precursor to pelvic serous cancer.
  • [MeSH-major] Carcinoma in Situ / genetics. Cystadenocarcinoma, Serous / genetics. Fallopian Tube Neoplasms / genetics. Genes, Neoplasm. Ovarian Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / analysis. Case-Control Studies. Cyclin E / analysis. DNA Damage. Fallopian Tubes / pathology. Female. Genes, BRCA1. Genes, BRCA2. Genes, p53. Genetic Markers. Humans. Immunohistochemistry / methods. Ki-67 Antigen / analysis. Microdissection. Mutation. Ovary / pathology. Polymerase Chain Reaction / methods. Staining and Labeling

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  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • [ErratumIn] J Pathol. 2007 Sep;213(1):116
  • (PMID = 17117391.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA83944; United States / NCI NIH HHS / CA / K08 CA108748; United States / NCI NIH HHS / CA / P50 CA10500
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin E; 0 / Genetic Markers; 0 / Ki-67 Antigen
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46. Moodley M, Bramdev A: Frozen section: Its role in gynaecological oncology. J Obstet Gynaecol; 2005 Oct;25(7):629-34
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  • Frozen section allows intraoperative evaluation to distinguish benign from malignant tumors in order to tailor the extent of surgery necessary.
  • [MeSH-major] Frozen Sections / methods. Genital Neoplasms, Female / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Diagnosis, Differential. Endometrial Neoplasms / pathology. Endometrial Neoplasms / surgery. False Negative Reactions. False Positive Reactions. Female. Humans. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Sensitivity and Specificity. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / surgery

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  • (PMID = 16263532.001).
  • [ISSN] 0144-3615
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 52
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47. Chang WC, Meux MD, Yeh BM, Qayyum A, Joe BN, Chen LM, Coakley FV: CT and MRI of adnexal masses in patients with primary nonovarian malignancy. AJR Am J Roentgenol; 2006 Apr;186(4):1039-45
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  • CONCLUSION: Such adnexal masses may be metastases to the ovaries, primary ovarian malignancy, or incidental benign disorders.
  • MRI may help characterize incidental benign entities such as endometriosis, fibroma, and peritoneal inclusion cysts.
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Genital Neoplasms, Female / complications. Genital Neoplasms, Female / pathology. Humans. Middle Aged. Neoplasm Metastasis

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  • (PMID = 16554576.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Chen EY, Mehra K, Mehrad M, Ning G, Miron A, Mutter GL, Monte N, Quade BJ, McKeon FD, Yassin Y, Xian W, Crum CP: Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube. J Pathol; 2010 Sep;222(1):110-6
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  • The 'p53 signature' is a benign secretory cell outgrowth in the distal Fallopian tube that shares properties with ovarian serous cancer-including p53 mutations-and is a putative serous cancer precursor.
  • SCOUTs are discretely localized alterations commonly containing altered expression of multiple genes within histologically benign tubal epithelium.
  • This study reveals, for the first time, an entity (SCOUT) that is associated with serous cancer, expands the topography of altered PAX2 expression in the female genital tract mucosa and highlights another potential pathway disturbance involved in early serous carcinogenesis in the Fallopian tube.

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  • (PMID = 20597068.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R21 CA124688-02S1; United States / NCI NIH HHS / CA / P50 CA105009; United States / NIGMS NIH HHS / GM / R01 GM083348; United States / NCI NIH HHS / CA / R21 CA124688; United States / NCI NIH HHS / CA / 1R21CA124688-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ NIHMS207936; NLM/ PMC2914810
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49. Yamaguchi K, Kaku T, Enjoji M, Kato M, Anai M, Kawakita M, Hamasaki N, Tanaka M: [Urine diacetylspermine as a novel tumor marker]. Rinsho Byori; 2005 Feb;53(2):130-5
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  • [Title] [Urine diacetylspermine as a novel tumor marker].
  • A urine tumor marker, diacetylspermine, was examined in patients with recurrent pancreato-biliary carcinoma, liver tumor, lung carcinoma and gynecologic malignancies.
  • Concerning uterine cervical tumor, the value of the urine marker increased with the grade of dysplasia.
  • The sensitivity for ovarian carcinoma was 100%, while that for benign ovarian tumor was 0%.
  • These findings suggest that urine diacetylspermine is a useful tumor marker in hepatocellular carcinoma, lung cancer and gynecologic malignancy as well as pancreatobiliary carcinoma.
  • [MeSH-major] Biliary Tract Neoplasms / diagnosis. Biomarkers, Tumor / urine. Genital Neoplasms, Female / diagnosis. Liver Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Pancreatic Neoplasms / diagnosis. Spermine / analogs & derivatives. Spermine / urine
  • [MeSH-minor] Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Sensitivity and Specificity

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  • (PMID = 15796046.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 2FZ7Y3VOQX / Spermine; 77928-71-3 / N',N''-diacetylspermine
  • [Number-of-references] 6
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50. Cremer ML, Alonzo TA, Alspach AE, Shulman IA, Cernosek S, Tsai S, Kalichanda N, Felix JC: Diagnostic reproducibility of cervical intraepithelial neoplasia 3 and atrophy in menopausal women on hematoxylin and eosin, Ki-67, and p16 stained slides. J Low Genit Tract Dis; 2010 Apr;14(2):108-12
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  • MATERIALS AND METHODS: Confirmed cases of CIN 3 and benign atrophic changes were reviewed independently by 4 pathologists.
  • [MeSH-minor] Aged. Female. Histocytochemistry / methods. Humans. Immunohistochemistry / methods. Ki-67 Antigen / analysis. Menopause. Middle Aged. Neoplasm Proteins / analysis. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 20354418.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / P16 protein, human
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51. Canis M, Jardon K, Niro J, Rabischong B, Bourdel N, Botchorishvili R, Pouly JL, Mage G: [Endoscopic management of gynecological malignancies: an update. 2007]. Bull Acad Natl Med; 2007 Oct;191(7):1357-65; discussion 1365-6
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  • Animal studies suggest that the risk of tumor dissemination in the non traumatized peritoneum may be higher after pneumoperitoneum than after laparotomy, and they also show the importance of the surgeon's experience and technique.
  • By controlling these parameters we may, in future, be able to create a peritoneal environment suitable for oncologic indications and thereby prevent or minimize the risk of peritoneal dissemination and postoperative tumor growth.
  • In contrast, restaging of early ovarian cancer initially managed as a benign mass is a good indication for the laparoscopic approach.
  • [MeSH-major] Endoscopy / methods. Genital Neoplasms, Female / surgery. Gynecologic Surgical Procedures / methods
  • [MeSH-minor] Animals. Carcinoma / secondary. Carcinoma / surgery. Endometrial Neoplasms / surgery. Female. Humans. Neoplasm Seeding. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Peritoneal Neoplasms / secondary. Pneumoperitoneum, Artificial / adverse effects. Pneumoperitoneum, Artificial / methods. Swine. Uterine Cervical Neoplasms / surgery

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  • (PMID = 18447057.001).
  • [ISSN] 0001-4079
  • [Journal-full-title] Bulletin de l'Académie nationale de médecine
  • [ISO-abbreviation] Bull. Acad. Natl. Med.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 30
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52. Melichar B, Solichová D, Freedman RS: Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):240-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Among other biochemical indicators of systemic immune and inflammatory activity, activation of macrophages by interferon-gamma induces a marked increase in the production of neopterin.
  • In addition to tumors of other primary locations, increased urinary and serum neopterin concentrations have been reported in patients with gynecological cancers, including epithelial ovarian carcinoma, cervical carcinoma, endometrial carcinoma, uterine sarcomas, and vulvar carcinoma, but not in women with benign neoplasms or precancerous disorders.
  • Elevated levels of neopterin have also been observed in the tumor microenvironment.
  • [MeSH-major] Genital Neoplasms, Female / immunology. Genital Neoplasms, Female / therapy. Immunotherapy / methods. Neopterin / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers / analysis. Endometrial Neoplasms / immunology. Endometrial Neoplasms / mortality. Endometrial Neoplasms / pathology. Female. Humans. Middle Aged. Neoplasm Staging. Ovarian Neoplasms / immunology. Ovarian Neoplasms / mortality. Ovarian Neoplasms / pathology. Prognosis. Sensitivity and Specificity. Survival Analysis. Treatment Outcome. Uterine Cervical Neoplasms / immunology. Uterine Cervical Neoplasms / mortality. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16445639.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 670-65-5 / Neopterin
  • [Number-of-references] 134
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53. Cuschieri K, Wentzensen N: Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev; 2008 Oct;17(10):2536-45
The Lens. Cited by Patents in .

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  • Human papillomavirus (HPV) infection of the genital tract is very common and normally follows a benign clinical course; however, in an unfortunate minority of infected individuals, it can cause disease that sometimes leads to cancer.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasm Proteins / genetics. Papillomaviridae / isolation & purification. Papillomavirus Infections / diagnosis. RNA, Messenger / analysis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Mass Screening / methods. Precancerous Conditions / diagnosis. Precancerous Conditions / genetics. Precancerous Conditions / virology

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  • (PMID = 18842994.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA CP010124-14
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / RNA, Messenger
  • [Number-of-references] 89
  • [Other-IDs] NLM/ NIHMS212843; NLM/ PMC2900792
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