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1. Li T, Wang L, Yu HH, Sun HC, Qin LX, Ye QH, Fan J, Tang ZY: Hepatic angiomyolipoma: a retrospective study of 25 cases. Surg Today; 2008;38(6):529-35
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  • PURPOSE: We report our experience of diagnosing and treating hepatic angiomyolipoma (HAML), a rare benign mesenchymal tumor.
  • All tumors were composed of varying proportions of smooth muscle, adipose tissue, and blood vessels, and showed positive immunohistochemical staining for HMB-45.
  • The definitive diagnosis of HAML is challenging and depends on the presence of HMB-45-positive myoid cells.
  • [MeSH-major] Angiomyolipoma / diagnosis. Angiomyolipoma / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / analysis. Female. Hepatectomy. Humans. Magnetic Resonance Imaging. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Prognosis. Retrospective Studies. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 18516533.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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2. Pironi D, Vendettuoli M, La Gioia G, Arcieri S, Filippini A: A large Brunner's gland adenoma: an unusual cause of gastrointestinal bleeding. Case report and literature review. Ann Ital Chir; 2010 Mar-Apr;81(2):147-51
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  • Brunner's gland adenoma is a rare benign tumour of the duodenum.
  • We report a rare case of a very large Brunner's gland adenoma in a 38-year-old female presenting with severe anaemia but without obstructive symptoms and detected by ultrasonography.
  • The tumour was managed by surgical removal and during a six month follow-up the patient remained symptom-free without any recurrence.
  • [MeSH-major] Adenoma / complications. Brunner Glands. Duodenal Neoplasms / complications. Gastrointestinal Hemorrhage / etiology

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  • (PMID = 20726394.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 45
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3. Travaini LL, Petralia G, Trifirò G, Ravasi L, Galetta D, Carbone G, Falcini F, Spaggiari L, Bellomi M, Paganelli G: [18F]FDG positron emission tomography/computed tomography and multidetector computed tomography roles in thymic lesion treatment planning. Lung Cancer; 2008 Sep;61(3):362-8
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  • A non-invasive way to determine the nature of thymic lesions would help identify the patients which are true candidates for surgery.
  • Our retrospective study aims to assess multidetector computed tomography and 2-[(18)F]fluoro-2-deoxyglucose positron emission tomography/computed tomography ([(18)F]FDG-PET/CT) capacity to distinguish benign from malignant thymic lesions.
  • MDCT scans were focused on morphologic features and invasiveness characteristics.
  • Student's t-test was performed on SUVbw max stratified for thymic epithelial tumors.
  • RESULTS: In the group of benign lesions MDCT correctly identified well-defined margins of masses in 8 out of 8 patients whereas [(18)F]FDG-PET/CT was negative in 7 out of 8 patients.
  • However, they are two non-invasive complementary techniques which can be used to differentiate benign from high-risk malignant thymic lesions.
  • [MeSH-major] Positron-Emission Tomography / methods. Radiotherapy Planning, Computer-Assisted / methods. Thymus Neoplasms / pathology. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Retrospective Studies

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  • (PMID = 18358558.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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4. Bonanomi G, Mandalà L, Maruzzelli L: Laparoscopic staged adjustable gastric banding and liver resection in morbidly obese patient. Obes Surg; 2010 Aug;20(8):1186-90
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  • We report the case of a 34-year old morbidly obese female, with a history of polycystic ovarian syndrome and birth control pill therapy, who underwent laparoscopic gastric banding.
  • On laparoscopic exploration, a 4-cm liver neoplasm that was missed by preoperative ultrasound was incidentally found.
  • The intraoperative biopsy was suggestive for a benign lesion of hepatocellular origin but could not make the differential diagnosis between focal nodular hyperplasia and adenoma.
  • The neoplasm had atypical features on postoperative magnetic resonance imaging and was suggestive of liver adenoma.
  • Atypical liver neoplasms are subject to potential degeneration, rupture, and bleeding; therefore, they should be treated surgically to allow final diagnosis and potential cure of the disease.
  • In this case, a staged approach was effective in obtaining substantial weight loss and a lesser degree of liver steatosis to enable the performance of a laparoscopic liver resection.
  • [MeSH-major] Gastroplasty. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery. Obesity, Morbid / surgery

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  • (PMID = 18830783.001).
  • [ISSN] 1708-0428
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Yu YH, Son BK, Jun DW, Kim SH, Jo YJ, Park YS, Hong BW, Joo JE: [A case of desmoid tumor presenting as intra-abdominal abscess]. Korean J Gastroenterol; 2009 May;53(5):315-9
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  • [Title] [A case of desmoid tumor presenting as intra-abdominal abscess].
  • Desmoid tumor is a rare benign tumor derived from fibrous sheath or musculoaponeurotic structure.
  • The tumor is benign histologically but considered as malignant clinically because it has high propensity on infiltrative growth with local invasion and tendency to recurrence after local excision.
  • Especially, when this tumor happens to be in the intra-abdomen, the prognosis is worse because it can cause intestinal obstruction, ureter obstruction and, fistula formation.
  • This tumor occurs more frequently in patients with familial adenomatous polyposis (FAP), in post-partume women, and at old surgical incision site.
  • We report a rare case of the young male patient who presented with an acute abdomen and underwent laparotomy and was found to have an intra-abdominal desmoid tumor with abscess formation.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Abscess / diagnosis. Adult. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19458469.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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6. Wei JT, Calhoun E, Jacobsen SJ: Urologic diseases in america project: benign prostatic hyperplasia. J Urol; 2008 May;179(5 Suppl):S75-80
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  • [Title] Urologic diseases in america project: benign prostatic hyperplasia.
  • PURPOSE: Benign prostatic hyperplasia (BPH), the most common benign neoplasm in American men, is a chronic condition that is associated with progressive lower urinary tract symptoms and affects almost 3 of 4 men during the seventh decade of life.
  • RESULTS: In 2000 approximately 4.5 million visits were made to physician offices to for a primary diagnosis of BPH and almost 8 million visits were made with a primary or secondary diagnosis of BPH.

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  • [CommentIn] J Urol. 2008 May;179(5 Suppl):S81 [18405762.001]
  • [ReprintOf] J Urol. 2005 Apr;173(4):1256-61 [15758764.001]
  • (PMID = 18405761.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / N01 DK012460
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Manucha V, Sun CC: Cytologic findings and differential diagnosis in hepatic Epithelioid hemangioendothelioma: a case report. Acta Cytol; 2008 Nov-Dec;52(6):713-7
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  • [Title] Cytologic findings and differential diagnosis in hepatic Epithelioid hemangioendothelioma: a case report.
  • BACKGROUND: Epithelioid hemangioendothelioma is a rare tumor of vascular origin with nonspecific clinical and radiologic presentation.
  • CASE: We describe a rare case of unifocal, hepatic hemangioendothelioma in a 47-year-old woman; a broad differential diagnosis of malignant neoplasm was considered during on-site evaluation of fine needle aspiration (FNA); diagnosis was made on subsequent core biopsy.
  • To better describe the cytologic findings, FNA was performed on the resected tumor.
  • The cytologic feature of this tumor, comparison with histol ogy findings and the differential diag nosis are discussed in detail.
  • CONCLUSION: A correct diagnosis of hepatic epithelioid hemangioendothelioma can be rendered in cytology when an adequate specimen is obtained.
  • The smears are characterized by a discohesive population of atypical cells in a clean background, fragments of metachromatic stroma, scattered benign hepatocytes and bile duct epithelium.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 19068677.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Abrahão AC, Camisasca DR, Bonelli BR, Cabral MG, Lourenço SQ, Torres SR, Pinto DS Jr: Recurrent bilateral gingival peripheral calcifying epithelial odontogenic tumor (Pindborg tumor): a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Sep;108(3):e66-71
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  • [Title] Recurrent bilateral gingival peripheral calcifying epithelial odontogenic tumor (Pindborg tumor): a case report.
  • Calcifying epithelial odontogenic tumor (CEOT) is an extremely rare, benign neoplasm, accounting for approximately 1% of all odontogenic tumors.
  • The presumptive diagnosis was bilateral pyogenic granuloma.
  • Morphologic features, and histochemical and immunohistochemical tests revealed bilateral peripheral calcifying odontogenic epithelial tumor.
  • Gingival masses must be carefully evaluated for clinical and histologic evidence of neoplasia.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Odontogenic Tumors / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Gingival Diseases / diagnosis. Granuloma, Pyogenic / diagnosis. Humans. Immunohistochemistry

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  • (PMID = 19716494.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Hutchinson CB, Canlas K, Evans JA, Obando JV, Waugh M: Endoscopic ultrasound-guided fine needle aspiration biopsy of the intrapancreatic accessory spleen: a report of 2 cases. Acta Cytol; 2010 May-Jun;54(3):337-40
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  • BACKGROUND: Intrapancreatic accessory spleen (IPAS) can pose a challenge in the diagnostic workup by mimicking a pancreatic neoplasm.
  • Reports of IPAS identified by endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) are scant in the literature, and increased recognition of this benign entity may reduce misdiagnosis and unnecessary surgical intervention.
  • In both cases, the cytomorphologic appearance of smears and cell blocks demonstrated aggregates of benign splenic tissue characteristic of both white and red pulp.
  • One cell block demonstrated benign splenic and pancreatic parenchyma immediately adjacent to one another without an apparent intervening capsule.
  • Definitive tissue diagnosis in these 2 cases avoided not only unnecessary surgical intervention but also the need for consideration of a "watch and wait" strategy with further imaging and possible additional biopsy attempts.
  • [MeSH-major] Choristoma / diagnosis. Pancreatic Diseases / diagnosis. Spleen
  • [MeSH-minor] Adenocarcinoma / diagnosis. Antigens, CD / metabolism. Biomarkers / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Endocrine Gland Neoplasms / diagnosis. Endosonography. Female. Humans. Male. Middle Aged. Pancreatic Neoplasms / diagnosis

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  • (PMID = 20518423.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers
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10. Satish Rao BS, Krishnanand BR, Krishan A: Androgen & vitamin D nuclear receptor expression in archival breast tumour samples. Indian J Med Res; 2006 Jan;123(1):73-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Androgen & vitamin D nuclear receptor expression in archival breast tumour samples.
  • BACKGROUND & OBJECTIVE: Breast tumour cells have receptors for androgen and vitamin D and their clinical significance is not completely understood.
  • Therefore, the present study was undertaken to analyze androgen and vitamin D receptor levels in human primary infiltrating ductal breast carcinomas (IDC) and benign breast tumour archival samples and to find out their correlation, if any, with the clinical findings.
  • METHODS: Paraffin blocks of benign and malignant breast tumours were sectioned, deparaffinized, and nuclei released by pepsin digestion.
  • RESULTS: Androgen receptor positive nuclei ranged from 16-66 per cent in the IDC tumours as compared to 36-67 per cent in the benign tumours.
  • Based on flow cytometric comparison of AR expression in AR positive and negative cell lines established earlier, 24 of 28 tumours from postmenopausal women were AR positive compared to all benign tumours and 32 of 33 tumours from pre-menopausal patients.
  • Vitamin D receptor positive nuclei ranged from 14-89 and 2-75 per cent in IDC and benign tumours, respectively.
  • All pre- or post-menopausal tumours were VDR positive as compared to 10 of 15 benign tumours that were VDR positive.
  • No correlation was seen between nuclear androgen and vitamin D receptor expression of the IDC or benign tumours.
  • No statistically significant correlation was found between nuclear receptor expression (per cent positive nuclei or antigen density) with that of tumour stage, lymph node status, tumour grade, patient age or menopausal status.
  • The expression of AR and VDR and the antigen density in the nuclei of the archival breast tumour samples were highly variable because of the tumour heterogeneity.
  • Future studies with fresh biopsy samples of tumour on AR and VDR levels and their up- or down-regulation may be useful while stratifying the patients for hormonal therapy.
  • [MeSH-major] Breast Neoplasms / chemistry. Receptors, Androgen / analysis. Receptors, Calcitriol / analysis

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  • (PMID = 16567872.001).
  • [ISSN] 0971-5916
  • [Journal-full-title] The Indian journal of medical research
  • [ISO-abbreviation] Indian J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Calcitriol
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11. Pery C, Meurette G, Ansquer C, Frampas E, Regenet N: Role and limitations of 18F-FDG positron emission tomography (PET) in the management of patients with pancreatic lesions. Gastroenterol Clin Biol; 2010 Sep;34(8-9):465-74
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  • The 18-fluorine-18-fluoro-2-deoxyglucose Positron Emission Tomography coupled with computed tomography is a non invasive exploration.
  • Several studies have shown that PET-CT has superior efficacy over conventional imaging techniques in distinguishing a benign pancreatic tumor from a malignant one.
  • It contributes to the diagnosis of cancer in patients with a doubtful mass, much more in case of chronic pancreatitis.
  • PET-CT is also an important help for the diagnosis of cystic tumors of the pancreas; the results can affect the management strategy.
  • It is interesting for the endocrine tumors, particularly since the emergence of new markers.
  • The aim of this paper is to summarize the role and limitations of 18-F-FDG PET-CT in the management of patients with pancreatic lesions (adenocarcinoma, cystic tumors, endocrine tumors, etc…) concerning the malignancy diagnosis, the detection of metastases, the monitoring after non surgical treatments and to evaluate interpretation difficulties, particularly in case of diabetes or chronic pancreatitis.
  • [MeSH-major] Fluorodeoxyglucose F18. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radionuclide imaging. Cystadenocarcinoma / pathology. Cystadenocarcinoma / radionuclide imaging. Cystadenoma / pathology. Cystadenoma / radionuclide imaging. Humans. Insulinoma / radionuclide imaging. Neoplasm Metastasis / radionuclide imaging. Neoplasm Staging. Pancreatitis / radionuclide imaging. Prognosis

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  • [Copyright] Copyright © 2010. Published by Elsevier Masson SAS.
  • (PMID = 20688444.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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12. Zanelli M, Cortecchia S, Righi E, Caprara L, De Lillo M, Costa F, Galanti G, Bondi A: Epithelioid angiomyolipoma of the kidney: case report. Pathologica; 2008 Jun;100(3):202-5
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  • Renal angiomyolipoma is a benign tumour histologically characterized by a mixture of adipose tissue, smooth muscle cells and thick walled blood vessels.
  • Long-believed to be a benign hamartoma, angiomyolipoma is now considered to arise from perivascular epithelioid cells.
  • Positivity for HMB45, Melan A, CD68 and CD117 are useful for diagnosis.
  • Herein, we report the clinicopathologic and immunohistochemical features of a renal tumour composed of large epithelioid mononucleated or multinucleated cells with abundant acidophilic cytoplasm and prominent nucleoli.
  • Despite the morphologic resemblance of this tumour to renal cell carcinoma, its phenotype (HMB45, Melan A and CD68 positivity and keratin negativity) parallels the phenotypic profile of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18841830.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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13. Baratta A, Gorin RJ, Costa R: Sister Mary Joseph nodule: a case report. Cutis; 2007 Dec;80(6):469-72
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  • It is a rare occurrence but may represent the first sign of a visceral malignancy and therefore should prompt a thorough search for the primary tumor.
  • We report a case of a 66-year-old man who was referred for evaluation of an enlarging umbilical lesion.
  • After a full metastatic workup, the tumor of origin was identified as adenocarcinoma of the sigmoid colon.
  • Benign tumors of the umbilicus are uncommon.
  • This case report serves to emphasize the importance of obtaining a histologic diagnosis when any new lesion presents in the umbilical region.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Skin Neoplasms / secondary. Umbilicus / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Diagnosis, Differential. Fluorouracil. Humans. Leucovorin. Male. Organoplatinum Compounds

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  • (PMID = 18246878.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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14. Skoulakis CE, Papadakis CE, Datseris GE, Drivas EI, Kyrmizakis DE, Bizakis JG: Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature. Acta Otorhinolaryngol Ital; 2007 Apr;27(2):90-3
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  • [Title] Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature.
  • Fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells.
  • Based on the location of this tumour, fibrous histiocytoma are usually divided into cutaneous types and those involving deep tissues.
  • The diagnosis of fibrous histiocytoma may be clinically difficult when the lesion is located in the deep tissues, and is frequently confirmed after local excision.
  • The most important diagnostic distinction is the separation of this tumour from aggressive forms of fibrohistiocytic neoplasms, including dermatofibrosarcoma protuberans and malignant fibrous histiocytoma.
  • The lesion had been totally excised under local anaesthesia, and histopathology revealed a benign fibrous histiocytoma.
  • The diagnosis, location, treatment and prognosis of fibrous histiocytoma are also discussed.
  • [MeSH-major] Cheek / pathology. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 17608138.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC2640009
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15. Garioni E, Danesino GM, Madonia L: Pilomatricoma: Sonographic features. J Ultrasound; 2008 Jun;11(2):76-8
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  • Pilomatricomas (also known as calcifying epitheliomas of Malherbe) are benign subcutaneous tumors that arise from the cutaneous adnexa and usually affect young subjects.
  • Diagnosis is based on clinical and histological findings.

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  • (PMID = 23396664.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3553250
  • [Keywords] NOTNLM ; Color Doppler / Pilomatricoma / Ultrasonography
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16. Balaji R, Ramachandran K: Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint. Childs Nerv Syst; 2009 Apr;25(4):497-501
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  • PURPOSE: Desmoplastic infantile gangliogliomas (DIG) are rare benign intracranial neoplasms of early childhood with involvement of superficial cerebral cortex and leptomeninges.
  • The purpose of the study was to determine the alterations in metabolite ratios occurring in the neoplasm and combine with magnetic resonance (MR) imaging features to narrow down the diagnosis.
  • Single-voxel short TE (1)H MR spectroscopy was used to study the changes in metabolite ratios in the tumor.
  • RESULTS: Comparison of metabolite ratios between normal brain tissue and tumor-affected region showed lower N-acetyl aspartate to creatine (Cr; 1.58 vs.1.28), higher choline to Cr (0.82 vs.2.03), and no significant change in myo-inositol to Cr (0.42 vs.0.39).
  • CONCLUSION: MR spectroscopy and imaging provide valuable information in the diagnosis of DIG.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / metabolism. Ganglioglioma / diagnosis. Ganglioglioma / metabolism
  • [MeSH-minor] Aspartic Acid / analogs & derivatives. Aspartic Acid / metabolism. Brain / pathology. Brain / physiopathology. Child. Choline / metabolism. Creatine / metabolism. Diagnosis, Differential. Humans. Inositol / metabolism. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy. Male

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  • Hazardous Substances Data Bank. (L)-ASPARTIC ACID .
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  • (PMID = 19139903.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 30KYC7MIAI / Aspartic Acid; 4L6452S749 / Inositol; 997-55-7 / N-acetylaspartate; MU72812GK0 / Creatine; N91BDP6H0X / Choline
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17. Ławicki S, Czygier M, Bedkowska E, Wojtukiewicz M, Szmitkowski M: Comparative evaluation of plasma levels and diagnostic values of macrophage-colony stimulating factor in patients with breast cancer and benign tumors. Pol Arch Med Wewn; 2008 Sep;118(9):464-9
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  • [Title] Comparative evaluation of plasma levels and diagnostic values of macrophage-colony stimulating factor in patients with breast cancer and benign tumors.
  • The direct production of this cytokine has been reported in tumor cell lines in vitro and in solid tumors in vivo.
  • OBJECTIVES: In the present study, the levels of M-CSF in patients with breast cancer and in those with a benign breast tumor were evaluated.
  • PATIENTS AND METHODS: The study group was made up of 70 patients with breast cancer and 20 patients with benign tumors and the control group of 30 healthy women.
  • RESULTS: Statistically higher levels of M-CSF and CA 15-3 were found in breast cancer patients as compared to the benign tumor and control groups.
  • The diagnostic sensitivity of M-CSF (58%), a specificity (93%), PV(+ve) (94%) and PV(-ve) (43%) were higher or equal to the values obtained for CA 15-3 (49%, 93%, 93% and 40%, respectively).
  • CONCLUSIONS: The above data suggests that M-CSF might be useful in both diagnostics and differential diagnosis of benign tumors and breast cancer (except for the lowest degree of the clinical progression).
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Breast Neoplasms / diagnosis. Macrophage Colony-Stimulating Factor / blood
  • [MeSH-minor] Adult. Aged. CA-125 Antigen / blood. Enzyme-Linked Immunosorbent Assay. Female. Humans. Middle Aged. Neoplasm Staging. Poland. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 18846980.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 81627-83-0 / Macrophage Colony-Stimulating Factor
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18. Kim SK, Kim DL, Han HS, Kim WS, Kim SJ, Moon WJ, Oh SY, Hwang TS: Pyrosequencing analysis for detection of a BRAFV600E mutation in an FNAB specimen of thyroid nodules. Diagn Mol Pathol; 2008 Jun;17(2):118-25
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  • [Title] Pyrosequencing analysis for detection of a BRAFV600E mutation in an FNAB specimen of thyroid nodules.
  • BACKGROUND: Fine-needle aspiration biopsy (FNAB) is the primary means of distinguishing benign from malignant and of guiding therapeutic intervention in thyroid nodules.
  • However, 10% to 30% of cases with indeterminate cytology in FNAB need other diagnostic tools to refine diagnosis.
  • None of 22 benign nodules had BRAF mutation in both pyrosequencing and direct DNA sequencing.
  • None of 6 benign nodules, including 3 follicular adenomas and 3 nodular hyperplasias, had BRAF mutation.
  • [MeSH-major] Adenocarcinoma / genetics. DNA Mutational Analysis / methods. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics. Thyroid Nodule / genetics
  • [MeSH-minor] Biopsy, Fine-Needle. Cell Line, Tumor. DNA, Neoplasm / analysis. Humans. Polymerase Chain Reaction. Predictive Value of Tests


19. Burghaus S, Hölsken A, Buchfelder M, Fahlbusch R, Riederer BM, Hans V, Blümcke I, Buslei R: A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch; 2010 Mar;456(3):287-300
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  • [Title] A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.
  • Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants.
  • Herein, we characterized the cellular interface between the tumor and the surrounding brain tissue in 48 CP (41 adaCP and seven papCP) compared to non-neuroepithelial tumors, i.e., 12 cavernous hemangiomas, 10 meningiomas, and 14 metastases using antibodies directed against glial fibrillary acid protein (GFAP), vimentin, nestin, microtubule-associated protein 2 (MAP2) splice variants, and tenascin-C.
  • Furthermore, the outer tumor cell layer of adaCP showed a distinct expression of MAP2, a novel finding helpful in the differential diagnosis of epithelial tumors in the sellar region.
  • Our data support the hypothesis that adaCP, unlike other non-neuroepithelial tumors of the central nervous system, create a tumor-specific cellular environment at the tumor-brain junction.
  • Whether this facilitates the characteristic infiltrative growth pattern or is the consequence of an activated Wnt signaling pathway, detectable in 90% of these tumors, will need further consideration.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Brain / metabolism. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Nerve Tissue Proteins / metabolism. Nestin. Tenascin / metabolism. Vimentin / metabolism

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  • (PMID = 20069432.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Tenascin; 0 / Vimentin
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20. Yavuz Balci A, Kayacioglu I, Vural U, Alkan P, Ates M, Tuygun AK, Yekeler I: Cardiac papillary fibroelastoma as a reason of transient ischemic attack for a young patient. Int J Cardiol; 2008 Jul 4;127(2):e86-8
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  • Cardiac papillary fibroelastoma is a rare primary cardiac tumor.
  • Although cardiac papillary fibroelastomas are benign tumors, they have potential life threatening complications such as sudden death, stroke, and myocardial infarction.
  • We excised the tumor completely without damage to the mitral valve.
  • We confirmed the diagnosis histopathologically.
  • Intracardiac tumors must be excised urgently due to severe complications.
  • [MeSH-major] Fibroma / complications. Heart Neoplasms / complications. Ischemic Attack, Transient / etiology. Mitral Valve / pathology. Papillary Muscles / pathology

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  • (PMID = 17706802.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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21. Parker WH: Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril; 2007 Apr;87(4):725-36
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  • [Title] Etiology, symptomatology, and diagnosis of uterine myomas.
  • OBJECTIVE: To review the currently available literature regarding the biology, etiology, symptoms, and diagnosis of uterine myomas.
  • RESULT(S): Although uterine myomas presently are not well understood, many advances have been made in the understanding of the hormonal factors, genetic factors, growth factors, and molecular biology of these benign tumors.
  • CONCLUSION(S): A summary of the available literature regarding the biology, etiology, symptomatology, and diagnosis of myomas shows that, although they are still not well understood, much has been learned about uterine myomas.
  • [MeSH-major] Myoma / etiology. Uterine Neoplasms / etiology
  • [MeSH-minor] Adult. Body Weight. Estrogen Replacement Therapy / adverse effects. Estrogens / physiology. Female. Growth Substances / physiology. Humans. Incidence. Leiomyoma / diagnosis. Leiomyoma / ethnology. Leiomyoma / etiology. Leiomyoma / genetics. Middle Aged. Pregnancy. Progesterone / physiology. Risk Factors. Sarcoma / genetics. Smoking / adverse effects

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  • (PMID = 17430732.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; 0 / Growth Substances; 4G7DS2Q64Y / Progesterone
  • [Number-of-references] 98
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22. Jelenc F, Brencic E: Laparoscopically assisted resection of an ascending colon lipoma causing intermittent intussusception. J Laparoendosc Adv Surg Tech A; 2005 Apr;15(2):173-5
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  • Colonic lipomas are relatively uncommon clinical entity, although they are among the most common nonepithelial benign tumors of the colon.
  • We report a case of a 56-year-old man who was suffering from abdominal pain and 4 weeks of intermittent diarrhea.
  • Histology confirmed the diagnosis of benign lipoma.
  • Aspects of preoperative diagnosis and treatment are discussed, and we review the literature.
  • [MeSH-major] Colectomy / methods. Colonic Neoplasms / surgery. Intussusception / surgery. Laparoscopy. Lipoma / surgery

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  • (PMID = 15898912.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Pacchioni D, Volante M, Casetta G, Sapino A, Marchiò C, Bussolati G: Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case. Am J Surg Pathol; 2007 Apr;31(4):632-6
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  • [Title] Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case.
  • We herein report an unusual case of a low-grade myxoid renal epithelial neoplasm, with peculiar and previously unreported morphologic and immunohistochemical features.
  • The tumor proved benign at follow-up.
  • A definitive classification and histogenetic interpretation of this previously unreported tumor type awaits description of further cases showing similar features which, perhaps, as it may happen, went so far unnoticed.
  • [MeSH-major] Kidney Neoplasms / pathology. Myoepithelioma / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Salivary Gland Neoplasms / pathology

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  • (PMID = 17414112.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Bossert T, Gummert JF, Battellini R, Richter M, Barten M, Walther T, Falk V, Mohr FW: Surgical experience with 77 primary cardiac tumors. Interact Cardiovasc Thorac Surg; 2005 Aug;4(4):311-5
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  • [Title] Surgical experience with 77 primary cardiac tumors.
  • BACKGROUND: To assess the prognosis and to develop management strategies for primary cardiac tumors all patients were included in an ongoing study.
  • 1994 until December 2003 we prospectively evaluated all patients with cardiac tumors.
  • RESULTS: There were a total of 77 primary cardiac tumors.
  • Seventy-three were benign: myxoma (n=59), papillary fibroelastoma (n=11), lipoma (n=2), fibroma (n=1) and four malignant sarcoma (n=4).
  • Minimal invasive right thoracotomy was utilized in 19 of 73 patients all with benign tumor.
  • There were two early deaths (3%): a myxoma patient with triple vessel disease and a LVEF less than 30% and one sarcoma patient.
  • No recurrence or late death was observed in the group of benign tumors.
  • However, two remaining patients with sarcoma had recurrent disease 10 and 15 month later, respectively.
  • CONCLUSION: Surgical excision of benign cardiac tumors is a safe and curative treatment, which is feasible using minimally invasive right thoracotomy approach and provides excellent results.
  • However, therapy of malignant cardiac tumors continues to have a poor prognosis despite individualization of approach.

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  • (PMID = 17670419.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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25. Catalano F, Furci M, Fancello R, Costanzo M: Giant recurrent fibromatosis of the breast: a case report. Clinical features and implications for treatment. Chir Ital; 2006 Jul-Aug;58(4):538-43
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  • Fibromatosis of the breast is a benign but locally aggressive neoplasm, which has been described under various names including extra-abdominal desmoid tumour and aggressive fibromatosis.
  • It is a rare condition, accounting for approximately 0.2% of all solid tumours of the breast.
  • Clinically and radiologically the lesion mimics breast cancer and the definitive diagnosis is provided by histology.
  • A high risk of local recurrence is a characteristic of this disease.
  • Radical excision of the tumour with clear histological margins decreases the likelihood of recurrence.
  • The main clinical and pathological characteristics of this rare disease are illustrated, emphasizing the difficulties encountered both in the diagnosis of the primary lesion and in the management of its giant recurrence, particularly as regards the possibility of obtaining a radical surgical excision and the option of performing breast reconstruction.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / surgery. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / surgery
  • [MeSH-minor] Adult. Female. Humans. Mastectomy. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Pectoralis Muscles / pathology. Pectoralis Muscles / surgery. Rectus Abdominis / pathology. Rectus Abdominis / surgery. Treatment Outcome

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  • (PMID = 16999161.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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26. Gilfillan CP: Review of the genetics of thyroid tumours: diagnostic and prognostic implications. ANZ J Surg; 2010 Jan;80(1-2):33-40
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  • [Title] Review of the genetics of thyroid tumours: diagnostic and prognostic implications.
  • Preoperative diagnosis is based on ultrasound and radionucleotide imaging as well as the fine-needle aspiration biopsy (FNAB).
  • These biopsies yield a large proportion of indeterminate results due to inadequate material for cytological diagnosis, or due to the cytological similarity of FAs and follicular carcinomas.
  • This technology has the potential to increase the specificity of this test, combining cytological with genetic testing to reduce the number of indeterminate results, thereby reducing the number of thyroidectomies performed for benign disease.
  • The practicality and utility of measuring these genetic alterations in FNAB specimens is also outlined as well as the potential for these tests to alter primary management and follow-up of patients with nodular thyroid disease.
  • [MeSH-major] Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. DNA, Neoplasm / genetics. Diagnosis, Differential. Humans. Mutation. Neoplastic Syndromes, Hereditary / genetics. Neoplastic Syndromes, Hereditary / pathology. Proto-Oncogenes / genetics. Thyroid Nodule / genetics. Thyroid Nodule / pathology

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  • (PMID = 20575878.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Number-of-references] 61
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27. Hsu PK, Hsu HS, Lee HC, Hsieh CC, Wu YC, Wang LS, Huang BS, Hsu WH, Huang MH: Management of primary chest wall tumors: 14 years' clinical experience. J Chin Med Assoc; 2006 Aug;69(8):377-82
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  • [Title] Management of primary chest wall tumors: 14 years' clinical experience.
  • BACKGROUND: Primary chest wall tumor is rare but it encompasses tumors of various origins.
  • We analyzed our experience with primary chest wall tumors with emphasis on its demographic presentation and management.
  • METHODS: From 1991 to 2004, 62 patients with the diagnosis of primary chest wall tumors were enrolled.
  • Malignant and benign tumors were equally distributed.
  • Chondrosarcoma and lymphoma were the 2 most common types of malignant chest wall tumors.
  • Nine of 31 patients (29.0%) with benign chest wall tumors were free of symptoms whereas patients with malignant chest wall tumors were all symptomatic (p = 0.002).
  • A definite diagnosis was obtained in 21 of 26 patients (80.7%) who received nonexcision biopsy.
  • All patients with primary chest wall tumors, except 6 who had medical treatment only, underwent surgical resection.
  • Patients with malignant chest wall tumors were older than those with benign tumors (p < 0.001).
  • The mean largest diameter of tumors was also larger in malignant tumors than in benign tumors (p = 0.04).
  • CONCLUSION: Patients with primary malignant chest wall neoplasm were older than those with benign tumors.
  • The mean size of malignant tumors was larger than that of benign tumors.
  • Adequate surgical resection remains the treatment of choice for patients with primary chest wall tumors.
  • Nonexcision biopsy should be reserved for patients with a past history of malignancy, suspicion of hematologic disease, and with high operative risk.
  • [MeSH-major] Thoracic Neoplasms / therapy. Thoracic Wall

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  • (PMID = 16970274.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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28. Sarica FB, Cekinmez M, Tufan K, Erdoğan B, Sen O, Altinörs MN: A rare case of massive NF1 with invasion of entire spinal axis by neurofibromas: case report. Turk Neurosurg; 2008 Jan;18(1):99-106
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  • Also called 'von Recklinghausen disease' or 'peripheral neurofibromatosis', it comprises 90% of all neurofibromatosis (NF) cases.
  • It is characterized by multiple peripheral nerve sheath tumors of benign character called neurofibromas.
  • In the present paper, we discuss an NF1 case in which paraspinal neurofibromas were observed along the complete spinal axis of a 32-year-old male patient who arrived at the clinic reporting increasingly intense pins and needles and weakness.
  • We discuss the patient's diagnosis, treatment, and prognosis, and relate this case to the literature.
  • [MeSH-minor] Adult. Disease Progression. Humans. Male. Spine

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  • (PMID = 18382989.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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29. Moolthiya W, Yuenyao P: The risk of malignancy index (RMI) in diagnosis of ovarian malignancy. Asian Pac J Cancer Prev; 2009;10(5):865-8
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  • [Title] The risk of malignancy index (RMI) in diagnosis of ovarian malignancy.
  • OBJECTIVE: To evaluate the ability of two risk of malignancy indices (RMI) based on serum levels of CA 125, ultrasonographic score, and menopausal status to discriminate between benign and borderline or malignant ovarian tumor.
  • CONCLUSION: The RMI is able to discriminate between benign and borderline or malignant ovarian tumor.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Mucinous / diagnosis. CA-125 Antigen / blood. Cystadenocarcinoma, Serous / diagnosis. Endometrial Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Female. Humans. Middle Aged. Neoplasm Staging. Postmenopause. Radioimmunoassay. Retrospective Studies. Sensitivity and Specificity. Survival Rate. Treatment Outcome. Ultrasonography

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  • (PMID = 20162854.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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30. Adam N, Lim SS, Ananda V, Chan SP: VIPoma syndrome: challenges in management. Singapore Med J; 2010 Jul;51(7):e129-32
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  • Vasoactive intestinal peptide-producing tumour (VIPoma) or Verner-Morrison syndrome is a very rare neuroendocrine tumour.
  • It occurs in less than ten percent of all pancreatic islet cell tumours, and about 70 percent to 80 percent of these tumours originate from the pancreas.
  • Diagnosis is characteristically delayed.
  • It may be curative in forty percent of patients with benign and non-metastatic disease.
  • Palliative surgery is indicated in extensive disease, followed by conventional somatostatin analogue (octreotide) therapy.
  • Somatostatin analogues improve hormone-mediated symptoms, reduce tumour bulk and prevent local and systemic effects.
  • We present a female patient with VIPoma syndrome, which had metastasised to the liver at diagnosis.
  • Unfortunately, after symptomatic improvement for three years, her disease progressed.
  • [MeSH-major] Liver Neoplasms / secondary. Palliative Care. Pancreatic Neoplasms / pathology. Vipoma / secondary
  • [MeSH-minor] Catheter Ablation / methods. Combined Modality Therapy. Disease Progression. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Octreotide / therapeutic use. Time Factors. Treatment Outcome


31. Ozen O, Demirhan B, Altinörs N: Correlation between histological grade and MIB-1 and p53 immunoreactivity in meningiomas. Clin Neuropathol; 2005 Sep-Oct;24(5):219-24
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  • OBJECTIVE: Meningiomas for the most part are slow-growing benign tumors, but complete removal can be difficult and recurrence is an issue.
  • The aim of this study was to re-evaluate tumors diagnosed as meningioma previously in our hospital, according to the latest World Health Organization classification.
  • We also examined the relationships among parameters such as brain invasion, histological grade and Ki-67 and p53 expression in these tumors.
  • MATERIALS AND METHODS: Meningioma biopsy specimens numbering 60 (48 grade I, 11 grade II, and 1 grade III tumors) were examined immunohistochemically using monoclonal antibodies for Ki-67 (MIB-1) and p53 protein.
  • The MIB-1 labeling index (LI) for each tumor was calculated as a percentage based on the number of stained cells per total cells counted.
  • The mean MIB-1 LI values for the grade I and grade II tumors were 1.1% and 2.3%, respectively.
  • [MeSH-major] Biomarkers, Tumor / analysis. Ki-67 Antigen / biosynthesis. Meningeal Neoplasms / pathology. Meningioma / pathology. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 16167545.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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32. Chiang FY, Lin JC, Lee KW, Wang LF, Tsai KB, Wu CW, Lu SP, Kuo WR: Thyroid tumors with preoperative recurrent laryngeal nerve palsy: clinicopathologic features and treatment outcome. Surgery; 2006 Sep;140(3):413-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid tumors with preoperative recurrent laryngeal nerve palsy: clinicopathologic features and treatment outcome.
  • METHODS: Six hundred and twenty-two patients underwent operation for various thyroid disease and were treated by the same surgeon.
  • The study was confined to 16 (3%) patients who suffered from a thyroid tumor with preoperative RLNP.
  • RESULTS: Of these 16 patients, 1 had benign thyroid disease, while the other 15 had malignancy (94%).
  • The recurrent laryngeal nerve could be dissected from the thyroid neoplasm in 3 patients, 2 of whom experienced recovery of this nerve's function postoperatively.
  • CONCLUSIONS: Thyroid tumor associated with RLNP is strongly suggestive of malignancy.
  • The RLN should be preserved if it has not been invaded by the tumor, because it offers a good chance of functional recovery postoperatively.
  • Radical excision of a resectable anaplastic or squamous cell carcinoma of the thyroid gland offers the chance, albeit small, of long-term survival in this study.
  • [MeSH-major] Thyroid Neoplasms / complications. Thyroid Neoplasms / surgery. Thyroidectomy / methods. Vocal Cord Paralysis / etiology. Vocal Cord Paralysis / surgery
  • [MeSH-minor] Aged. Carcinoma, Papillary / complications. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Female. Humans. Laryngeal Nerves / pathology. Laryngeal Nerves / physiology. Laryngeal Nerves / surgery. Male. Middle Aged. Prognosis. Retrospective Studies. Thyroid Gland / pathology. Thyroid Gland / surgery. Treatment Outcome

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  • (PMID = 16934603.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Maher MM, Shepard JA: Imaging of thymoma. Semin Thorac Cardiovasc Surg; 2005;17(1):12-9
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  • Thymomas are the most common mediastinal tumors, usually diagnosed initially by CT.
  • CT scanning can aid in characterization of thymoma and can successfully distinguish thymomas from other benign mediastinal tumors and from lymphoma.
  • [MeSH-major] Diagnostic Imaging / methods. Thymoma / diagnosis. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Female. Goiter / diagnosis. Goiter / epidemiology. Goiter / surgery. Humans. Incidence. Magnetic Resonance Imaging / methods. Male. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / epidemiology. Mediastinal Neoplasms / surgery. Neoplasm Staging. Positron-Emission Tomography / methods. Prognosis. Sensitivity and Specificity. Thymectomy / methods. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 16104356.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 34
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34. Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H, Hagiwara A, Otsuji E: Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis. Anticancer Res; 2008 Mar-Apr;28(2B):1169-79
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Regenerating gene type IV (RegIV) is a candidate marker for cancer and inflammatory bowel disease.
  • PATIENTS AND METHODS: RegIV mRNA levels in the peritoneal washes of 95 gastric cancer patients and 22 with benign disease were quantified by real-time RT-PCR.
  • A cut-off value for RegIV-positive expression was based on an analysis of negative control patients with benign disease, and gastric cancer patients above the cut-off value constituted the micrometastasis (MM+) group.
  • Combined analysis of CEA and RegIV improved the accuracy of diagnosis to 100%.
  • [MeSH-minor] Actins / biosynthesis. Actins / genetics. Animals. Biomarkers, Tumor. Carcinoembryonic Antigen / biosynthesis. Carcinoembryonic Antigen / genetics. Cell Line, Tumor. Gastric Mucosa / metabolism. Gastric Mucosa / physiology. HL-60 Cells. Humans. Male. Mice. Mice, Inbred C3H. Mice, Nude. Neoplasm Invasiveness. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Peritoneal Neoplasms / genetics. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / secondary. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Stomach Neoplasms / genetics. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. Transfection

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  • (PMID = 18505053.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Lectins, C-Type; 0 / REG4 protein, human; 0 / RNA, Messenger
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35. Landi B, Palazzo L: The role of endosonography in submucosal tumours. Best Pract Res Clin Gastroenterol; 2009;23(5):679-701
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  • [Title] The role of endosonography in submucosal tumours.
  • Submucosal tumours (SMTs) are relatively common findings in patients undergoing endoscopy, especially in upper gastrointestinal (GI) tract.
  • This term includes various non-neoplastic and neoplastic conditions.
  • In this review, the following issues will be addressed: the endosonographic features of SMT; the diagnostic accuracy of EUS; the ability of EUS to distinguish benign and malignant SMTs; the value of EUS-guided fine-needle aspiration (FNA); and the influence of EUS on clinical management.
  • [MeSH-major] Endoscopy, Gastrointestinal. Endosonography. Gastrointestinal Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Gastrointestinal Stromal Tumors / ultrasonography. Humans. Mucous Membrane / ultrasonography. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 19744633.001).
  • [ISSN] 1532-1916
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 33
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36. Kataoka K, Nishikawa T, Fujiwara T, Matsuura M: [Leiomyoma of the trachea; report of a case]. Kyobu Geka; 2010 Apr;63(4):336-9
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  • [Title] [Leiomyoma of the trachea; report of a case].
  • Leiomyoma of the trachea is a rare benign tumor.
  • Chest X-ray and computed tomography (CT) scan demonstrated a tracheal tumor.
  • Bronchofiberscopy revealed a polypoid round tumor in the trachea.
  • The tumor originated from the membranous portion of the trachea without narrow stalk.
  • Definitive diagnosis of tracheal leiomyoma was made by histological examination.
  • [MeSH-major] Leiomyoma / surgery. Tracheal Neoplasms / surgery

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  • (PMID = 20387511.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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37. Filipovski V, Banev S, Janevska V, Dukova B: Granular cell tumor of the breast: a case report and review of literature. Cases J; 2009;2:8551
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  • [Title] Granular cell tumor of the breast: a case report and review of literature.
  • A 22-year-old female patient presented with a breast mass lesion with a clinical suspicion of a fibroadenoma.
  • Histological evaluation revealed a rare benign neoplasm - granular cell tumor.Granular cell tumor is rare neoplasm that may arise in virtually any body site, and in 5% it occurs in the breast.
  • The histogenesis of this tumor is still rather controversial and currently the most acceptable theory is a Schwann cell origin.
  • The main histological feature is granular cytoplasm of the tumor cells.From a clinical point of view there is a similarity between granular cell tumor and mammary carcinoma on mammography and ultrasound.
  • Pathohistologically, sometimes, differential diagnostic difficulties exist concerning apocrine carcinoma, histiocytic lesions and metastatic neoplasms.

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  • [Cites] Arch Pathol Lab Med. 1992 Feb;116(2):206-8 [1733419.001]
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  • (PMID = 19918386.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769456
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38. Alobaid AS: Mucinous cystadenoma of the ovary in a 12-year-old girl. Saudi Med J; 2008 Jan;29(1):126-8
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  • Benign mucinous cystadenomas MCA are rare benign neoplasms in the pediatric age group.
  • The final pathology revealed a benign MCA.
  • Patients with mucinous tumors usually present late, this may lead to renal insufficiency secondary to urinary outflow obstruction.
  • The diagnosis of MCA should be considered in children who present with huge pelvi-abdominal masses.
  • [MeSH-major] Cystadenoma, Mucinous / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans

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  • (PMID = 18176687.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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39. Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL: Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum; 2009 Mar;52(3):520-5
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  • Multiple biopsies of macroscopically malignant rectal tumors and benign rectal mucosa were obtained from each patient for a total of 14 malignant and 9 benign samples.
  • RESULTS: Metabolomic profiles represented by principle components of metabolites measured from spectra differentiated between malignant and benign samples and correlated with the volume percent of cancer (P = 0.0065 and P = 0.02, respectively) and benign epithelium (P = 0.0051 and P = 0.0255, respectively), and with volume percent of stroma, and inflammation.
  • Future studies should determine its utility in in vivo applications for non-invasive pathologic evaluations of suspicious rectal lesions.

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  • (PMID = 19333056.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115746-03; United States / NCI NIH HHS / CA / R01 CA095624; United States / NCI NIH HHS / CA / CA095624; United States / NCI NIH HHS / CA / CA115746; United States / NCI NIH HHS / CA / CA095624-04; United States / NCI NIH HHS / CA / R01 CA115746; United States / NCI NIH HHS / CA / R01 CA095624-04; United States / NCI NIH HHS / CA / R01 CA115746-03
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS119443; NLM/ PMC2720561
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40. Segal A, Segal N, Gal A, Tumuluri K: Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor. Orbit; 2010 Dec;29(6):334-40
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  • [Title] Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor.
  • In 12(21.8%) patients a lesion with a benign diagnosis was previously excised from the same location.
  • In 2 of them histological re-examination resulted in a diagnosis of MSA.
  • Recurrence of the tumor was reported in 14(30%) patients.
  • CONCLUSIONS: MSA is a rare tumor of the eyelid with no clinically distinguishing features.
  • It should be suspected particularly with recurrent eyelid lesions and must be differentiated from metastatic disease.
  • The tumor may extend into the orbit and metastasize regionally.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Mohs Surgery / methods. Neoplasm Staging. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 21158574.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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41. Chen CM, Chen KH, Jung SM, Hsu HC, Wang CM: Central neurocytoma: 9 case series and review. Surg Neurol; 2008 Aug;70(2):204-9
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  • Whether the high score of functional outcome was correlated with benign tumor course or 5-year survival rate remains uncertain.
  • We recommend regular follow-up for detecting tumor growth or recurrence, although central neurocytomas are always benign.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Neurocytoma / diagnosis. Neurocytoma / therapy
  • [MeSH-minor] Activities of Daily Living. Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cerebral Angiography. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Glial Fibrillary Acidic Protein / metabolism. Humans. Ki-67 Antigen / analysis. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging. Male. Neurosurgical Procedures / methods. Radiotherapy / methods. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18262625.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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42. Plaza JA, Torres-Cabala C, Evans H, Diwan HA, Suster S, Prieto VG: Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum. Am J Dermatopathol; 2010 Apr;32(2):129-36
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  • [Title] Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum.
  • In up to 5% of patients, metastatic melanoma can be the first manifestation of the disease.
  • For the most part, the histologic diagnosis of metastatic melanoma poses little diagnostic difficulty; however, some metastases may adopt unusual or unfamiliar appearances mimicking other benign and malignant conditions.
  • We present a study of 192 cases of cutaneous metastatic melanomas with special emphasis on their spectrum of morphologic features.
  • Most tumors were located on the proximal legs, scalp, and arms and ranged from 0.8 to 3.0 cm.
  • One hundred ten cases showed the classic morphologic appearance of melanoma (well-circumscribed epithelioid dermal/subcutaneous nodule), 82 cases showed unusual histologic appearances that mimicked other benign and malignant neoplasms.
  • In 16 patients (8.3%), there was no evidence of primary melanoma and the cutaneous metastasis was the only manifestation of the disease.
  • The histologic diagnosis of cutaneous metastatic melanoma can pose difficulties for diagnosis, especially in the face of an unknown primary neoplasm.
  • Immunohistochemical stains plus careful clinical history helped to establish the correct diagnosis.
  • Our series illustrates that the differential diagnosis of cutaneous metastatic melanoma can be broad and difficult.
  • [MeSH-major] Melanoma / secondary. Neoplasms, Unknown Primary. Skin / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Antigens, Neoplasm / metabolism. Desmin / metabolism. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / metabolism. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 20010406.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm; 0 / CD68 antigen, human; 0 / Desmin; 0 / Ki-67 Antigen; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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43. Illian C, Kortmann HR, Künstler HO, Poll LW, Schofer M: Tenosynovial giant cell tumors as accidental findings after episodes of distortion of the ankle: two case reports. J Med Case Rep; 2009;3:9331
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  • [Title] Tenosynovial giant cell tumors as accidental findings after episodes of distortion of the ankle: two case reports.
  • INTRODUCTION: Tenosynovial giant cell tumors are benign tumors of uncertain pathogenesis.
  • Due to a high recurrence rate of up to 50%, some authors call a giant cell tumor a semimalignant tumor.
  • To date, less than 10 cases of tenosynovial giant cell tumor of the ankle have been published in the international medical literature.
  • CASE PRESENTATION: In this case report, we present two patients with localized tumors that were detected accidentally after the occurrence of ankle sprains with persisting pain in the joint.
  • The tumors were resected by open marginal surgery and regular follow-up examinations were carried out.
  • CONCLUSIONS: We present an unusual occurrence of a tumor along with a possible follow-up strategy, which has not been previously discussed in the international literature.

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  • (PMID = 20062758.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803852
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44. Chemli H, Dhouib M, Karray F, Abdelmoula M: [Risk factors for recurrence of maxillary odontogenic keratocysts]. Rev Stomatol Chir Maxillofac; 2010 Sep;111(4):189-92
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  • [Transliterated title] Les facteurs de risque de récidive des kératokystes odontogéniques des maxillaires.
  • PURPOSE: The odontogenic keratocyst is a benign tumor with a high recurrence rate and aggressive behavior.
  • The mandible was the most common site (30 cases).
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Chin / innervation. Dental Fistula / diagnosis. Female. Follow-Up Studies. Humans. Lip / innervation. Male. Middle Aged. Osteolysis / radiography. Paresthesia / diagnosis. Prognosis. Recurrence. Retrospective Studies. Risk Factors. Root Resorption / radiography. Sex Factors. Tomography, X-Ray Computed. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20553889.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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45. Kusumi T, Minakawa M, Fukui K, Saito S, Ohashi M, Sato F, Fukuda I, Kijima H: Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change. Cardiovasc Pathol; 2009 Nov-Dec;18(6):369-74
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  • [Title] Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change.
  • BACKGROUND: Cardiac myxoma is a benign neoplasm and is not considered to carry a risk of malignant transformation.
  • We describe a case of a cardiac tumor comprising typical myxoma and atypical cellular parts.
  • METHODS AND RESULTS: A 72-year-old woman was found to have a tumor in the left atrial chamber after undergoing echocardiographic investigation and so she underwent tumor excision surgery.
  • The excised tumor was composed of two components with different features with a smooth transition from one type to the other.
  • The apex of the tumor showed a gelatinous and villous appearance on gross examination, and histological examination revealed that the tumor cells had small oval nuclei and eosinophilic cytoplasm and were arranged in cords and vasoformative structures in the myxoid matrix.
  • The base of the tumor appeared as a solid mass on gross examination with hypercellular proliferation of spindle-shaped tumor cells and intersecting fascicles observed histologically.
  • On immunohistochemistry, the tumor cells were found to be positive for alpha-smooth muscle actin, calretinin, and CD34, and this immunoreactivity was decreased at the tip.
  • CONCLUSIONS: We diagnosed this tumor as cardiac myxoma with an atypical hypercellular component suggesting a malignant change.
  • [MeSH-major] Heart Neoplasms / pathology. Myxoma / pathology

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  • (PMID = 18619858.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Langner E, Del Negro A, Akashi HK, Araújo PP, Tincani AJ, Martins AS: Schwannomas in the head and neck: retrospective analysis of 21 patients and review of the literature. Sao Paulo Med J; 2007 Jul 5;125(4):220-2
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  • CONTEXT AND OBJECTIVE: Schwannomas are benign neoplasms of the peripheral nerves originating in the Schwann cells.
  • They occur in the head and neck region in only 25% of the cases, and may be associated with Von Recklinghausen's disease.
  • The present study retrospectively analyzed some data on this disease in the head and neck region and reviewed the literature on the subject.
  • DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas.
  • Four patients had a positive past history of type I neurofibromatosis or Von Recklinghausen's disease.
  • Tumor enucleation was performed in 16 patients; the other five required more extensive surgery.
  • They are solitary lesions, except in Von Recklinghausen's disease.
  • They are generally benign, and rarely recur.
  • The recommended surgical treatment is tumor enucleation.
  • [MeSH-major] Head and Neck Neoplasms. Neurilemmoma

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  • (PMID = 17992392.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 16
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47. Yazbek J, Raju SK, Ben-Nagi J, Holland TK, Hillaby K, Jurkovic D: Effect of quality of gynaecological ultrasonography on management of patients with suspected ovarian cancer: a randomised controlled trial. Lancet Oncol; 2008 Feb;9(2):124-31
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  • BACKGROUND: The diagnostic accuracy of ultrasonography for differentiating between benign and malignant adnexal masses is proportional to the expertise of the operator.
  • However, we do not know whether improved diagnostic accuracy will affect the management of these tumours.
  • METHODS: 165 patients who were referred to the regional gynaecological cancer centre at Guy's and St Thomas' NHS Foundation Trust (London, UK), between June 7, 2004, and April 23, 2006, with suspected adnexal tumours met the inclusion criteria.
  • A likely histological diagnosis was provided to clinicians after ultrasonography for 76 of 77 (99%) patients in the level III group compared with only 38 of 73 (52%) patients in the level II group.
  • [MeSH-major] Ovarian Neoplasms / ultrasonography. Quality of Health Care. Ultrasonography / standards
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Staging. Prospective Studies. Sensitivity and Specificity


48. Schmaltz R, Müller CS, Vogt T: [Sudden growth of previously indolent scalp nodule]. Hautarzt; 2010 Jun;61(6):518-21
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  • Cylindromas are benign adnexal tumors with eccrine and apocrine differentiation.
  • As our case shows, histological evaluation is mandatory, even when the clinical diagnosis seems obvious.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Multiple Primary / diagnosis. Scalp. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Disease Progression. Female. Humans. Laser Therapy

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  • [Cites] Br J Dermatol. 2001 Oct;145(4):653-6 [11703297.001]
  • [Cites] Dermatol Surg. 2003 Jun;29(6):647-9 [12786711.001]
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  • (PMID = 20490442.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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49. Czeczot H, Scibior-Bentkowska D, Skrzycki M, Majewska M, Podsiad M: [Lipid peroxidation level in gastrointestinal tract tumors]. Pol Merkur Lekarski; 2010 Nov;29(173):309-14
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  • [Title] [Lipid peroxidation level in gastrointestinal tract tumors].
  • Oxygen free radicals and their reactive derivatives participate in formation of chronic inflammation states, which facilitate development of gastrointestinal tract tumors.
  • The aim of the study was the determination of lipid peroxidation level in gastrointestinal tract tumors (stomach, liver, colon, and colorectal cancer to liver metastases).
  • MATERIAL AND METHODS: Materials for studies were obtained from 150 patients with gastrointestinal tract tumors: 10 with stomach cancer, 30 with malignant and benign liver cancers, 60 with primary colorectal cancer, and 50 with metachronous colorectal cancer liver metastases.
  • Tumor specimens, and normal adjacent tissues (6-7 cm from the edge of the tumor), which served as control tissue in studies, were collected from patients (with their consent) during surgery.
  • RESULTS: The study showed the highest concentration of TBARS in benign, and the lowest in malignant liver tumors.
  • Other types of gastrointestinal tumors studied, were characterized by similar levels of lipid peroxidation.
  • TBARS concentration in these tumors was approximately 2-fold higher than in malignant liver tumors and much lower than in benign tumors.
  • In all cancers of the digestive tract with the exception of malignant liver tumors increased level of TBARS was found, comparing with control tissue.
  • The level of lipid peroxidation in liver cirrhosis and malignant liver tumors was similar.
  • There were no significant differences in TBARS concentration in the tumors of particular sections of the intestine and normal colon.
  • The changes of lipid peroxidation level--a marker of oxidative stress in gastrointestinal tumors appear to be closely associated with their development stages (liver cirrhosis/malignant liver cancer; colorectal cancer/colorectal cancer liver metastases) and are likely to create such conditions, in which cancerous cells may proliferate, undergo gradual dedifferentiation and malignancy, and generate metastases.
  • [MeSH-major] Gastrointestinal Neoplasms / metabolism. Lipid Peroxidation. Liver Neoplasms / secondary

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  • (PMID = 21268915.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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50. De Flora S, Izzotti A: Mutagenesis and cardiovascular diseases Molecular mechanisms, risk factors, and protective factors. Mutat Res; 2007 Aug 1;621(1-2):5-17
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  • A variety of experimental and epidemiological findings are also in favor of the somatic mutation theory, which maintains that the earliest event in the atherogenic process is represented by mutations in arterial smooth muscle cells, akin to formation of a benign tumor.
  • [MeSH-minor] Animals. Atherosclerosis / epidemiology. Atherosclerosis / etiology. Atherosclerosis / genetics. Atherosclerosis / prevention & control. DNA Adducts / metabolism. Humans. Neoplasms / epidemiology. Neoplasms / etiology. Neoplasms / genetics. Neoplasms / prevention & control. Polymorphism, Genetic. Risk Factors

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  • (PMID = 17383689.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Adducts
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51. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Transliterated title] Siringoma condroide: revisión clínica e histológica de ocho casos.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • It is treated surgically and its diagnosis is histological.
  • RESULTS: Most of the cases occurred as well-defined nodular lesions, whose presumptive clinical diagnosis was adnexal or cystic pathology.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • The final treatment of these tumors is surgical.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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52. Landers KA, Burger MJ, Tebay MA, Purdie DM, Scells B, Samaratunga H, Lavin MF, Gardiner RA: Use of multiple biomarkers for a molecular diagnosis of prostate cancer. Int J Cancer; 2005 May 10;114(6):950-6
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  • [Title] Use of multiple biomarkers for a molecular diagnosis of prostate cancer.
  • We describe here 4 biomarkers, UDP-N-Acetyl-alpha-D-galactosamine transferase (GalNAc-T3; not previously associated with PCa), PSMA, Hepsin and DD3/PCA3, which, in combination, distinguish prostate cancer from benign prostate hyperplasia (BPH).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Biomarkers, Tumor / analysis. Prostatic Hyperplasia / diagnosis. Prostatic Hyperplasia / genetics. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / genetics
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Multivariate Analysis. N-Acetylgalactosaminyltransferases / analysis. N-Acetylgalactosaminyltransferases / genetics. Neoplasm Proteins / analysis. Neoplasm Proteins / genetics. Oligonucleotide Array Sequence Analysis. Polymerase Chain Reaction. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 15609297.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 2.4.1.- / N-Acetylgalactosaminyltransferases; EC 2.4.1.41 / polypeptide N-acetylgalactosaminyltransferase
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53. Saggiorato E, De Pompa R, Volante M, Cappia S, Arecco F, Dei Tos AP, Orlandi F, Papotti M: Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application. Endocr Relat Cancer; 2005 Jun;12(2):305-17
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  • [Title] Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application.
  • The distinction of benign from malignant follicular thyroid neoplasms remains a difficult task in diagnostic fine-needle aspiration cytology, and some discrepant results have been reported for the individual immunocytochemical markers of malignancy proposed so far.
  • The aim of this study was to test if the combined use of a panel of markers could improve the diagnostic accuracy in the preoperative cytological evaluation of 'follicular neoplasms' in an attempt to reduce the number of thyroidectomies performed for benign lesions.
  • The immunocytochemical expression of galectin-3, HBME-1, thyroperoxidase, cytokeratin-19 and keratan-sulfate was retrospectively analyzed in 125 consecutive fine-needle aspiration samples (cell blocks) of indeterminate diagnoses of 'follicular thyroid neoplasm', and compared with their corresponding surgical specimens, including 33 follicular carcinomas, 42 papillary carcinomas and 50 follicular adenomas.
  • The use of these two markers sequentially in non-oncocytic lesions (testing HBME-1 as a second marker whenever galectin-3 proved negative) increased the sensitivity and specificity up to 97% and 95% respectively.
  • Our data showed that, as compared with the use of single markers, the sequential combination of two markers represents the most accurate immunohistochemical panel in managing patients with a fine-needle aspiration biopsy diagnosis of 'follicular neoplasms', especially in otherwise controversial categories such as oncocytic tumours.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Biomarkers, Tumor / analysis. Immunohistochemistry. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans

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  • (PMID = 15947105.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Garman M, Metry D: Vulvar syringomas in a 9-year-old child with review of the literature. Pediatr Dermatol; 2006 Jul-Aug;23(4):369-72
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  • Syringomas are benign tumors of the eccrine sweat gland that are most common to the periorbital location.
  • We report a 9-year-old girl who had severe pruritus secondary to syringomas of the vaginal labia, and review the literature on this unusual disorder.
  • [MeSH-major] Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / surgery. Syringoma / pathology
  • [MeSH-minor] Child. Female. Humans. Treatment Outcome. Vulvar Neoplasms

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  • (PMID = 16918636.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Byrne HM, Alarcon T, Owen MR, Webb SD, Maini PK: Modelling aspects of cancer dynamics: a review. Philos Trans A Math Phys Eng Sci; 2006 Jun 15;364(1843):1563-78
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  • Cancer is a complex disease in which a variety of factors interact over a wide range of spatial and temporal scales with huge datasets relating to the different scales available.
  • In this paper, we explain why mathematics is a powerful tool for interpreting such data by presenting case studies that illustrate the types of insight that realistic theoretical models of solid tumour growth may yield.
  • These range from discriminating between competing hypotheses for the formation of collagenous capsules associated with benign tumours to predicting the most likely stimulus for protease production in early breast cancer.
  • [MeSH-major] Models, Biological. Neoplasms / blood supply. Neoplasms / physiopathology. Neovascularization, Pathologic / physiopathology. Spheroids, Cellular / physiology. Tumor Cells, Cultured / physiology

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  • (PMID = 16766361.001).
  • [ISSN] 1364-503X
  • [Journal-full-title] Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
  • [ISO-abbreviation] Philos Trans A Math Phys Eng Sci
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / E18413/2
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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56. Bialkowska-Hobrzanska H, Driman DK, Fletcher R, Harry V, Razvi H: Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue. Can J Urol; 2006 Feb;13(1):2967-74
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  • INTRODUCTION: The wide spectrum of biological behavior displayed by prostate cancer (PCa) warrants investigation of potential PCa-specific biomarkers that could identify more aggressive tumor types and therefore provide prognostic value.
  • The purpose of this study was to evaluate the clinical value of detection of over-expression of these biomarkers in the diagnosis and prognosis of PCa.
  • MATERIAL AND METHODS: Archival formalin-fixed, paraffin-embedded (FFPE) prostatectomy tissue from 26 patients with PCa (Gleason score 3-9, mean 7) and 14 patients with benign prostatic hyperplasia (BPH) were analyzed by reverse transcription polymerase chain reaction (RT-PCR) for semiquantitative transcript levels of hTERT, Survivin, DD3 and PCGEM1.
  • None of the tumor biomarkers showed a positive correlation with pathological stage and Gleason score.
  • [MeSH-major] Antigens, Neoplasm / genetics. DNA-Binding Proteins / genetics. Microtubule-Associated Proteins / genetics. Neoplasm Proteins / genetics. Prostatic Neoplasms / genetics. RNA, Messenger / biosynthesis. Telomerase / genetics
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Humans. Inhibitor of Apoptosis Proteins. Male. RNA, Long Noncoding. RNA, Untranslated

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  • (PMID = 16515751.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / BIRC5 protein, human; 0 / DNA-Binding Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / PCGEM1 non-coding RNA, human; 0 / RNA, Long Noncoding; 0 / RNA, Messenger; 0 / RNA, Untranslated; 0 / prostate cancer antigen 3, human; EC 2.7.7.49 / Telomerase
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57. Feng Y, Yang ZG, Chen T, Wang Q, Deng W: Giant plexiform neurofibroma with hemorrhage in cranio-maxillofacial region as depicted on CT and MRI. Eur J Med Res; 2010 Feb 26;15(2):84-7
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  • Plexiform neurofibroma (PN) is a rare benign tumor and a special subtype of neurofibromatosis type 1 (NF1).
  • [MeSH-major] Hemorrhage / diagnosis. Maxillary Neoplasms / diagnosis. Neurofibroma, Plexiform / diagnosis

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58. Li L, Yao JL, di Sant'Agnese PA, Bourne PA, Picken MM, Young AN, Shen SS, Huang J: Expression of claudin-7 in benign kidney and kidney tumors. Int J Clin Exp Pathol; 2008;1(1):57-64
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  • [Title] Expression of claudin-7 in benign kidney and kidney tumors.
  • Claudins, a family of tight junction-related transmembrane proteins, have been implicated in the pathogenesis of various human neoplasms.
  • We studied the expression of claudin-7 in benign and neoplastic kidneys by immunohistochemical staining.
  • Differential expression of Claudin-7 in different types of renal cell neoplasms can be useful in their differential diagnosis, particularly when used in a panel of markers.

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  • (PMID = 18784823.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480537
  • [Keywords] NOTNLM ; chromophobe / claudin-7 / clear cell / kidney / neoplasm / oncocytoma / papillary
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59. Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL: Subcutaneous atypical fibrous histiocytoma. Am J Dermatopathol; 2009 Jul;31(5):499-501
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  • Benign fibrous histiocytoma is one of the most frequent benign neoplasms mainly composed of a mixture of fibroblastic and histiocytic cells, especially found in the skin (dermatofibroma), particularly in the limbs.
  • The diagnosis of cutaneous benign fibrous histiocytoma is generally easy; however, rare variants may be difficult to identify, and the diagnosis only confirmed after exhaustive histopathological examination.
  • We report a case of a 38-year-old woman with a painless swelling on the abdominal wall, which was totally excised and histopathologically diagnosed as subcutaneous atypical fibrous histiocytoma.
  • Prominent hyaline collagen bundles surrounded by tumor cells were observed, predominantly at the periphery of the lesion.
  • Definitive diagnosis, although especially difficult in our case, is established by characteristic histological and immunohistochemical criteria.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry

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  • (PMID = 19542931.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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60. Dalpa E, Gourvas V, Baritaki S, Miyakis S, Samaras V, Barbatis C, Sourvinos G, Spandidos DA: High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland. J Clin Virol; 2008 Jun;42(2):182-5
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  • [Title] High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland.
  • BACKGROUND: Warthin's tumor is a common benign neoplasm of the salivary gland.
  • Human Herpes Virus 8 (HHV-8) is the etiologic agent for all forms of Kaposi's sarcoma (KS), and HHV-8 DNA is present in saliva, suggesting that non-sexual transmission is associated with latent infection of the salivary gland.
  • OBJECTIVES: To provide insights into the HHV-8 cell tropism, the presence of HHV-8 was investigated in a series of Warthin's tumors of the salivary gland and corresponding adjacent normal tissue.
  • STUDY DESIGN: Forty-three patients with Warthin's tumors (cystadenolymphoma) were tested for the presence of HHV-8 DNA, and corresponding adjacent normal tissue samples were obtained from 15 patients.
  • RESULTS: HHV-8 DNA was detected in 19 out of 43 (44%) salivary gland tumor samples.
  • Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens.
  • CONCLUSIONS: HHV-8 is frequently detected in adenoid salivary neoplasms, suggesting a significant role of the virus in the etiopathogenesis of the disease.
  • Larger studies are required to investigate the role of HHV-8 in the development or progression of Warthin's tumors.
  • [MeSH-major] Adenolymphoma / virology. Herpesvirus 8, Human / isolation & purification. Salivary Gland Neoplasms / virology. Salivary Glands / virology

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  • (PMID = 18339579.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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61. Habibi Z, Nejat F, Naeini PE, Mahjoub F: Teratoma inside a myelomeningocele. J Neurosurg; 2007 Jun;106(6 Suppl):467-71
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  • The coincidence of an MMC and a neoplasm is rare, and only limited reports on the concurrence of a teratoma within an MMC have been published.
  • The postoperative histopathological assessments in 15 (4.5%) of these patients revealed evidence of a teratoma inside the MMC.
  • CONCLUSIONS: The special feature of a protruding fingerlike appendage or intraoperative detection of a cystic portion of an MMC without direct connection to the spinal canal can be possible signs of teratoma concurrent with an MMC.
  • Teratoma inside an MMC is a benign neoplasm, without any recurrence after standard surgery for an MMC.
  • [MeSH-major] Central Nervous System Neoplasms / complications. Meningomyelocele / complications. Teratoma / complications

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  • (PMID = 17566404.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Schlosser RJ, Woodworth BA, Gillespie MB, Day TA: Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas. ORL J Otorhinolaryngol Relat Spec; 2006;68(2):69-72
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  • INTRODUCTION: Endoscopic resection of benign neoplasms, such as inverted papilloma, has been well described.
  • There are limited case reports of endoscopic resection of benign vascular tumors, including hemangiomas, or those with low-grade malignant potential, such as hemangiopericytomas.
  • Four tumors involved the skull base; 2 of these underwent preoperative embolization.
  • One patient had a CSF leak that occurred as the tumor was removed from the cribriform plate and that was successfully repaired intraoperatively.
  • The average size of the tumors was 5.8 cm x 2.7 cm with all tumors at least 2.5 cm in greatest dimension by computed tomography or magnetic resonance imaging.
  • The largest tumor was 12 cm in greatest dimension.
  • An average of 8 intraoperative frozen section margins was taken around 5 tumors, with all margins of each tumor clear on final pathology.
  • CONCLUSION: Large vascular neoplasms of the sinonasal cavity, such as hemangiomas and hemangiopericytomas, can be safely removed using endoscopic techniques.
  • [MeSH-major] Endoscopy / methods. Hemangioma / surgery. Hemangiopericytoma / surgery. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16428897.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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63. Muzumdar D, Ventureyra EC: Tonsillar herniation and cervical syringomyelia in association with posterior fossa tumors in children: a case-based update. Childs Nerv Syst; 2006 May;22(5):454-9
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  • [Title] Tonsillar herniation and cervical syringomyelia in association with posterior fossa tumors in children: a case-based update.
  • BACKGROUND: Posterior fossa tumors most commonly occur in children.
  • The symptomatology is predominantly directed towards the tumor.
  • CASE REPORT: We describe a case of a pilocytic astrocytoma of the cerebellum in a 13-year-old girl who presented with clinical features of progressively worsening raised intracranial pressure and secondary tonsillar herniation and cervical syringomyelia.
  • Magnetic resonance (MR) imaging showed a large midline inhomogenously enhancing vermian tumor causing moderate obstructive hydrocephalus.
  • The tumor was resected through a suboccipital craniectomy.
  • CONCLUSIONS: The occurrence of tonsillar herniation and syringomyelia in association with a slow growing benign tumor like pilocytic astrocytoma of the cerebellum is uncommon.
  • Surgical extirpation of the tumor restores the normal cerebrospinal fluid circulation at the foramen magnum and produces an excellent outcome.
  • [MeSH-major] Astrocytoma. Hernia / etiology. Infratentorial Neoplasms / complications. Palatine Tonsil / pathology. Syringomyelia / etiology
  • [MeSH-minor] Adolescent. Disease Progression. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 16397818.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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64. Craig S, Bui-Mansfield LT, Lusk JD: Radiology pathology conference of Brooke Army Medical Center: trichoblastoma of breast. Clin Imaging; 2009 Jul-Aug;33(4):311-3
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  • The differential diagnosis of a superficial breast lesion detected on mammography typically includes seborrheic keratosis, dermal nevus, epidermal inclusion cyst, and basal cell carcinoma with subcutaneous invasion [Kopans DB.
  • The case presented is of a trichoblastoma of the superficial breast.
  • Trichoblastoma is a benign skin neoplasm that is rarely found in the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mammography / methods

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  • (PMID = 19559355.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Chen JH, Yu CY, Pai CY, Chan DC, Chen CJ, Yu JC, Liu YC: Castleman's disease in the left upper retroperitoneal space mimicking an adrenal neoplasm: report of a case and literature review. Jpn J Clin Oncol; 2005 Jun;35(6):353-6
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  • [Title] Castleman's disease in the left upper retroperitoneal space mimicking an adrenal neoplasm: report of a case and literature review.
  • Castleman's disease is a rare disorder characterized by benign proliferation of lymphoid tissue.
  • The left suprarenal location of this localized disease may be mistaken for an adrenal tumor.
  • We report a case of a 51-year-old woman with a Castleman's tumor located superomedial to the upper pole of the left kidney that mimicked an adrenal neoplasm.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Giant Lymph Node Hyperplasia / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Retroperitoneal Space / pathology. Tomography, X-Ray Computed

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  • (PMID = 15928190.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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66. Acar C, Akkas BE, Sen I, Sozen S, Kitapci MT: False positive 18F-FDG PET scan in adrenal oncocytoma. Urol Int; 2008;80(4):444-7
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  • Today, 18F-FDG PET is utilized to differentiate benign from malignant non-functioning adrenal masses.
  • To make a differential diagnosis, 18F-FDG PET was performed.
  • Preoperative laboratory studies showed that the mass was non-functioning.
  • We present the disassociation between preoperative 18F-FDG PET and pathologic findings of a benign adrenocortical oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radionuclide imaging. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods
  • [MeSH-minor] Adrenalectomy / methods. Adult. Diagnosis, Differential. False Positive Reactions. Female. Fluorodeoxyglucose F18. Follow-Up Studies. Humans. Immunohistochemistry. Neoplasm Staging. Preoperative Care / methods. Treatment Outcome

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18587259.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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67. Demirer AN, Kemal Y, Gursoy A, Sahin M, Tutuncu NB: Clinicopathological characteristics of thyroid cancer in patients on dialysis for end-stage renal disease. Thyroid; 2008 Jan;18(1):45-50
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  • [Title] Clinicopathological characteristics of thyroid cancer in patients on dialysis for end-stage renal disease.
  • METHODS: We performed a retrospective analysis on end-stage renal disease (ESRD) patients on dialysis and thyroidectomized patients without ESRD (2000-2006).
  • Then we compared the data of thyroid cancer patients on dialysis (n = 9) with the data of patients who had histopathologically verified benign thyroid disease on dialysis (n = 23) and with the histopathological data of thyroid cancer patients without ESRD.
  • Two patients had lymphatic metastasis at diagnosis.
  • Eight PTCs were classified as tumor-node-metastasis (TNM) stage I and one as stage II.
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Papillary, Follicular / pathology. Kidney Failure, Chronic / therapy. Renal Dialysis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Case-Control Studies. Female. Humans. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Prevalence. Prognosis. Retrospective Studies. Risk Factors


68. Jadhav MN, Yelikar BR, Patil SB: Epithelioid angiomyolipoma of the kidney: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):338-40
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  • Renal angiomyolipoma is a distinctive benign neoplasm that occurs either sporadically or in patients with tuberous sclerosis complex.
  • Immunohistochemistry confirmed the diagnosis of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 17883064.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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69. Sallinen H, Heikura T, Laidinen S, Kosma VM, Heinonen S, Ylä-Herttuala S, Anttila M: Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer. Int J Gynecol Cancer; 2010 Dec;20(9):1498-505
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  • [Title] Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer.
  • INTRODUCTION: The aims of the study were to explore the levels of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in patients with benign, borderline, or malignant epithelial ovarian tumors and to compare them to those of healthy controls.
  • METHODS: We enrolled 150 patients with ovarian neoplasms and 34 women with healthy ovaries in this study.
  • Serum samples were collected preoperatively at the time of diagnosis, and Ang-1 and Ang-2 levels were measured with an enzyme-linked immunosorbent assay.
  • In addition, Ang-2 levels were significantly higher in patients with ovarian carcinoma compared with patients with benign (P < 0.0005) or borderline ovarian tumors (P = 0.011).
  • High serum levels of Ang-1 and Ang-2 were associated with primary residual tumor more than 1 cm after debulking surgery, and high Ang-2 levels correlated positively with an advanced tumor stage (P = 0.042).
  • CONCLUSIONS: Patients with ovarian cancer have higher serum levels of angiopoietins than patients with benign or borderline tumors reflecting the increased angiogenesis.
  • [MeSH-major] Angiopoietin-2 / blood. Carcinoma / diagnosis. Neoplasm Staging / methods. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Angiopoietin-1 / analysis. Angiopoietin-1 / blood. Biomarkers, Tumor / analysis. Biomarkers, Tumor / blood. Case-Control Studies. Female. Humans. Middle Aged. Neoplasms, Glandular and Epithelial / blood. Neoplasms, Glandular and Epithelial / diagnosis. Neoplasms, Glandular and Epithelial / mortality. Neoplasms, Glandular and Epithelial / surgery. Preoperative Period. Prognosis. Survival Analysis. Young Adult

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  • (PMID = 21119365.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiopoietin-1; 0 / Angiopoietin-2; 0 / Biomarkers, Tumor; Ovarian epithelial cancer
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70. Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM: Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol; 2009 Dec;62(12):1127-35
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  • [Title] Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours.
  • MDM2 and CDK4 protein overexpression have also been identified in these tumours.
  • METHODS: IHC for MDM2/CDK4 was carried out on a series of 129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours.
  • The cases were divided into four groups: WDLPS (n = 19), DDLPS (n = 10), benign adipocytic tumours (BAT) (n = 17), and other mesenquimal tumours (OMT) (n = 83).
  • IHC results were compared in each group and the diagnostic efficacy of the test in identifying WDLPS and DDLPS among the other soft tissue tumours was determined.
  • A percentage of tumour cell positivity was evaluated to better characterise the pattern of tumour immunostaining.
  • The highest specificity was achieved when a case was considered positive with strong and diffuse immunoreactivity in more than 30% of the neoplastic cells (94.1% and 100%, and 77.1% and 98.8%, respectively).
  • Considering a strong and diffuse immunostaining pattern in most of the neoplastic cells achieves the best results in identifying these tumours.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase 4 / metabolism. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Sensitivity and Specificity

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  • (PMID = 19946100.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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71. D'Angelo VA, Galarza M, Catapano D, Monte V, Bisceglia M, Carosi I: Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases. Neurosurgery; 2008 Jun;62(6 Suppl 3):1066-75
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  • [Title] Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases.
  • OBJECTIVE: Optimal surgical management in lateral ventricle tumors remains controversial.
  • We conducted a retrospective study of patients with these lesions treated with a surgical strategy on the basis of tumor origin: primary or secondary ventricular and associated transependymal development.
  • METHODS: A total of 72 patients underwent surgery for lateral ventricle tumors.
  • Sixty-five percent of tumors were benign and low-grade tumors.
  • Final morbidity correlated well with preoperative clinical condition and pathological diagnosis.
  • CONCLUSION: Lateral ventricle tumors can be treated best by careful selection of the approach according to tumor origin and development.
  • Overall, the transcallosal approach is preferred, but in patients with transependymal growth or large primary or secondary ventricular tumors, the transcortical is a better option.

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  • [ReprintOf] Neurosurgery. 2005 Jan;56(1 Suppl):36-45; discussion 36-45 [15799791.001]
  • (PMID = 18695527.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Cavigelli SA, Yee JR, McClintock MK: Infant temperament predicts life span in female rats that develop spontaneous tumors. Horm Behav; 2006 Sep;50(3):454-62
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  • [Title] Infant temperament predicts life span in female rats that develop spontaneous tumors.
  • At death, these males had various complex pathologies, precluding identification of specific hormonal mechanisms underlying adult disease progression and mortality.
  • To minimize the variance of disease processes at the end of life, we conducted a longitudinal study with female Sprague-Dawley rats prone to high rates of spontaneous mammary and pituitary tumors.
  • For females that developed either mammary or pituitary tumors, those that had been neophobic (least exploratory) as infants died approximately 6 months earlier than their neophilic (most exploratory) sisters.
  • In the case of mammary tumors, both benign and malignant, neophobic females developed palpable tumors earlier than neophilic females, whereas the interval between first palpation and death was the same for all females, indicating psychosocial regulation of early rather than later stages of the disease.
  • During puberty, when mammary tissue is proliferating and differentiating, neophobic females experienced more irregular cycles with prolonged "luteal" phases, suggesting a role for prolactin, prolonged progesterone and fewer estrogen surges during this sensitive period for mammary tumor risk.
  • Thus, we identified prolactin, estrogen, progesterone and possibly corticosterone dynamics as candidates for neuroendocrine mechanisms linking infant temperament with onset of adult neoplastic disease.
  • [MeSH-major] Exploratory Behavior / physiology. Longevity / physiology. Mammary Neoplasms, Animal / physiopathology. Pituitary Neoplasms / physiopathology. Temperament / physiology

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  • (PMID = 16836996.001).
  • [ISSN] 0018-506X
  • [Journal-full-title] Hormones and behavior
  • [ISO-abbreviation] Horm Behav
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / F32 HD008693; United States / NICHD NIH HHS / HD / F32 HD08693; United States / NIA NIH HHS / AG / P01 AG018911; United States / NIMH NIH HHS / MH / R37 MH41788
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids
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73. Talati H, Radhi J, Popovich S, Marcaccio M: Hepatic Epithelioid Angiomyolipoma: Case Series. Gastroenterology Res; 2010 Dec;3(6):293-295
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  • : Hepatic epithelioid angiomyolipoma (AML) is a rare, benign, mesenchymal neoplasm found in both males and females, and most commonly encountered in adult females.
  • The tumor cells are strongly positive for homatropine methylbromide-45 (HMB-45) and smooth muscle actin by immunohistochemistry, which are the key markers for accurate pathological diagnosis.
  • Hepatic AML should be considered in the differential diagnosis of a well circumscribed hepatic mass, even in the absence of an adipose tissue component.

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  • (PMID = 27942312.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenoma / Epithelioid angiomyolipoma / Hepatocellular carcinoma / Liver
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74. Shepherd CJ, Rizzo S, Ledaki I, Davies M, Brewer D, Attard G, de Bono J, Hudson DL: Expression profiling of CD133+ and CD133- epithelial cells from human prostate. Prostate; 2008 Jun 15;68(9):1007-24
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  • BACKGROUND: Recent evidence suggests that prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized.
  • METHODS: We analyzed CD133-positive (CD133+) and -negative (CD133-) sub-populations of high-integrin expressing epithelial cells isolated from benign human prostate tissue and hormone-refractory prostate cancer (HRPC).
  • RESULTS: CD133+ cells freshly isolated from benign prostate tissue exhibited an expression profile characteristic of a putative stem/progenitor cell population, with transcripts involved in biological processes ranging from development and ion homeostasis to cell communication.
  • The profile of CD133- cells was consistent with that of a transit amplifying population, suggesting up-regulated proliferation and metabolism.
  • Comparison of benign populations to those from HRPC showed some similarities between CD133+ profiles but also revealed significant differences that provide a tumor-specific pattern, which included evidence of increased metabolic activity and active proliferation.
  • Subsequently, we demonstrated protein expression of a number of candidate genes in these cell populations and in benign tissue.
  • In a novel observation we also found expression of some of these markers in prostate tumors, including the oligodendrocyte lineage transcription factor OLIG1.
  • [MeSH-major] Antigens, CD / biosynthesis. Glycoproteins / biosynthesis. Prostatic Hyperplasia / immunology. Prostatic Neoplasms / immunology

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  • (PMID = 18398820.001).
  • [ISSN] 0270-4137
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0501019
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 Antigen; 0 / Antigens, CD; 0 / Glycoproteins; 0 / PROM1 protein, human; 0 / Peptides; 0 / RNA, Messenger
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75. Siniscalchi EN, Angileri FF, Mastellone P, Catalfamo L, Giusa M, Conti A, De Ponte FS, Tomasello F: Anterior skull base reconstruction with a galeal-pericranial flap. J Craniofac Surg; 2007 May;18(3):622-5
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  • Excision of neoplasm and trauma involving the anterior cranial base may often result in communication between the intracranial and extracranial compartments.
  • Ten underwent a combined maxillofacial-neurosurgical approach for the removal of a benign tumor involving the anterior skull base.
  • [MeSH-minor] Adult. Craniocerebral Trauma / surgery. Craniotomy. Facial Injuries / surgery. Female. Fibrin Tissue Adhesive / therapeutic use. Follow-Up Studies. Graft Survival. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications. Retrospective Studies. Skull Base Neoplasms / surgery. Subdural Effusion / surgery. Tissue Adhesives / therapeutic use. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17538328.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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76. Ho H, Chen YD, Tan PH, Wang M, Lau WK, Cheng C: Inverted papilloma of urinary bladder: is long-term cystoscopic surveillance needed? A single center's experience. Urology; 2006 Aug;68(2):333-6
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  • IP is an uncommon benign tumor of the urinary tract.
  • No patient had a synchronous or previous bladder tumor.
  • All were solitary tumors, most commonly found at the bladder neck.
  • CONCLUSIONS: Although our cases exhibited benign biologic behavior, the presence of cytologic atypia and suspicious urine cytology require exclusion of TCC with an inverted pattern.
  • [MeSH-major] Cystoscopy. Papilloma, Inverted / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16904447.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Remzi FH, Kirat HT, Geisler DP: Laparoscopic single-port colectomy for sigmoid cancer. Tech Coloproctol; 2010 Sep;14(3):253-5
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  • METHODS: Laparoscopic single-port sigmoid colectomy through a 3-cm umbilical incision was performed on a patient with a diagnosis of sigmoid cancer.
  • Colonoscopy performed 1 year after surgery showed no neoplasm or polyp identified.
  • Abdomen and pelvis CT also found no evidence of recurrence or metastatic disease.
  • CONCLUSION: Single-port laparoscopic surgery may allow common benign procedures via an incision in the umbilicus.
  • [MeSH-major] Laparoscopy / methods. Sigmoid Neoplasms / pathology. Sigmoid Neoplasms / surgery. Umbilicus / surgery
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Length of Stay. Middle Aged. Neoplasm Staging. Pain, Postoperative. Sigmoidoscopy / methods. Treatment Outcome

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  • [Cites] Lancet Oncol. 2005 Jul;6(7):477-84 [15992696.001]
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  • (PMID = 19953288.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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78. Jalpota Y, Tewari V, Madan R: Recurrent nephrogenic adenoma of urinary bladder in a renal allograft recipient--a case report. Indian J Pathol Microbiol; 2006 Apr;49(2):261-3
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  • Nephrogenic adenoma is a rare benign tumour-like lesion within the urothelial mucosa of the urinary tract.
  • It may be an incidental finding in bladder of a patient presenting with haematuria, dysuria and bladder growth after renal allograft transplant.
  • Clinically it mimics bladder neoplasm.
  • Definite diagnosis is established by histological examination of tumor.
  • Though it attains an extensive spread in bladder mucosa and has a high tendency to recur, the clinical course is benign.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms. Neoplasm Recurrence, Local / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans

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  • (PMID = 16933732.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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79. Ding GP, Ye CS, Liu MF, Zhen LF, Liao JJ: [Relationship between D2-40-labeled lymphatic vessel invasion and lymph node metastasis of breast cancer]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Oct;30(10):2301-3
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  • METHODS: Immunohistochemistry was used to detect the expression of D2-40 and lymphatic invasion in 72 cases of breast cancer and 15 benign breast tumor tissues, and their correlations to the clinicopathological factors were analyzed.
  • [MeSH-major] Antibodies, Monoclonal. Breast Neoplasms / diagnosis. Immunohistochemistry / methods. Lymphatic Vessels / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / pathology. Middle Aged. Neoplasm Staging

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  • (PMID = 20965831.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal
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80. Bornemann A, Koitschev A: A 57-year-old female with a benign tumor in the ethmoid sinus. Brain Pathol; 2006 Oct;16(4):335-6
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  • [Title] A 57-year-old female with a benign tumor in the ethmoid sinus.
  • [MeSH-major] Ethmoid Sinus / pathology. Neurocytoma / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Mucocele / pathology. Tomography, X-Ray Computed

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  • (PMID = 17107604.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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81. Rachappa MM, Triveni MN: Capillary hemangioma or pyogenic granuloma: A diagnostic dilemma. Contemp Clin Dent; 2010 Apr;1(2):119-22
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  • Pyogenic granulomas and hemangiomas of oral cavity are well-known benign lesions.
  • The clinical diagnosis of such an uncommon occurrence can be quite challenging as they sometimes may mimic more serious lesions such as malignancies.
  • The purpose of this article is to report an unusual case of benign tumor occurring on hard palate which was clinically diagnosed as pyogenic granuloma and histopathologically as capillary hemangioma.

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  • (PMID = 22114397.001).
  • [ISSN] 0976-2361
  • [Journal-full-title] Contemporary clinical dentistry
  • [ISO-abbreviation] Contemp Clin Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3220083
  • [Keywords] NOTNLM ; Capillary hemangioma / portwine stain / pyogenic granuloma / vascular malformations
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82. Sterker I, Hagert-Winkler A, Gradistanac T, Frerich B: [Granular cell tumor of the orbit]. Ophthalmologe; 2007 Sep;104(9):803-5
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  • [Title] [Granular cell tumor of the orbit].
  • Granular cell tumor (GCT, Abrikossoff tumor) is an extremely rare, benign tumor with a neurogenic origin occurring most commonly in the upper aerodigestive tract.
  • [MeSH-major] Granular Cell Tumor. Orbital Neoplasms

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  • [Cites] J Craniofac Surg. 2004 Nov;15(6):971-7; discussion 978-9 [15547385.001]
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  • (PMID = 17440732.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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83. Li S, Xue HD, Li J, Sun F, Jiang B, Liu D, Sun HY, Jin ZY: Application of whole body diffusion weighted MR imaging for diagnosis and staging of malignant lymphoma. Chin Med Sci J; 2008 Sep;23(3):138-44
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  • [Title] Application of whole body diffusion weighted MR imaging for diagnosis and staging of malignant lymphoma.
  • OBJECTIVE: To evaluate the clinical impact of whole body diffusion weighted imaging (WB-DWI) on diagnosis and staging of malignant lymphoma.
  • RESULTS: WB-DWI was positive in all 18 cases with lymphoma, 5 cases with metastatic lymph nodes and 4 of 8 cases with benign lymphadenopathy.
  • The mean ADC value of lymphomatous, metastatic and benign lymph nodes was (0.87 +/- 0.17) x 10(-3), (0.98 +/- 0.09) x 10(-3) and (1.20 +/- 0.10) x 10(-3) mm2/s.
  • There was significant difference in ADC value between benign lymph nodes and other two groups (P < 0.01).
  • The sensitivity, specificity and accuracy of WB-DWI in diagnosis of lymphoma were 100% (18/18), 30.8% (4/13) and 71.0% (22/31).
  • When an ADC value of 1.08 x 10(-3) mm2/s was used as the threshold value for differentiating malignant from benign lymph nodes, the best results were obtained with sensitivity of 87.8% and specificity of 91.3%.
  • CONCLUSIONS: WB-DWI is a sensitive, but less specific technique for diagnosis of lymphoma.

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  • (PMID = 18853847.001).
  • [ISSN] 1001-9294
  • [Journal-full-title] Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
  • [ISO-abbreviation] Chin. Med. Sci. J.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] China
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84. Jordan E, Choe D, Miller T, Chamarthy M, Brook A, Freeman LM: Utility of bone scintigraphy to determine the appropriate vertebral augmentation levels. Clin Nucl Med; 2010 Sep;35(9):687-91
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  • PURPOSE OF THE REPORT: Vertebral augmentation procedures have been used as an effective treatment for back pain due to vertebral compression fracture from different causes, including metastatic disease and osteoporosis.
  • However, diagnosis and localization of the causative vertebral level(s) may be difficult using any single imaging modality.
  • MATERIALS AND METHODS: The study consisted of a retrospective chart review of 44 patients who underwent bone scintigraphs and vertebroplasties at Montefiore Medical Center from 2002 to 2008.
  • The data was reviewed by a panel consisting of a neuroradiologist and nuclear medicine physician for agreement.
  • Although no significant difference was seen in the positivity of bone scans to subsequent vertebroplasty levels between benign or metastatic compression fractures (79% vs. 76%), a difference was observed when single level vertebroplasty patients were compared with multiple-level vertebroplasty patients (87% vs. 69%).
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Neoplasm Metastasis. Osteoporosis / radionuclide imaging. Osteoporosis / surgery. Spinal Fractures / radionuclide imaging. Spinal Fractures / surgery. Spinal Neoplasms / radionuclide imaging. Spinal Neoplasms / surgery. Whole-Body Irradiation

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  • (PMID = 20706042.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Sturgeon C, Shen WT, Clark OH, Duh QY, Kebebew E: Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy? J Am Coll Surg; 2006 Mar;202(3):423-30
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  • [Title] Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy?
  • BACKGROUND: Laparoscopic adrenalectomy for tumors > 6 cm is controversial because of the risk of malignancy, but data to support this position are mostly from small series.
  • STUDY DESIGN: Adrenocortical carcinomas (ACC) recorded in the Surveillance, Epidemiology, and End Results (SEER) database (1988 to 2000) were compared with benign functional or nonfunctional adrenal cortical adenomas (excluding aldosteronomas) operated on at our institution between January 1, 1993, and July 1, 2003.
  • RESULTS: We identified 457 patients with ACC and 47 patients with adrenal cortical adenomas; 376 and 44 neoplasms, respectively, had tumor size data available.
  • Tumor size was larger in ACC (12.0 +/- 5.6 versus 4.2 +/- 1.9 cm, mean +/- SD, p < 0.05).
  • For ACC presenting with local disease, the sensitivity, specificity, and likelihood ratios of tumor size to predict malignancy were 96%, 52%, and 2.0, respectively, for tumors > or = 4 cm; 90%, 80%, and 4.4 for tumors > or = 6 cm; 77%, 95%, and 16.9 for tumors > or = 8 cm; and 55%, 98%, and 24.4 for tumors > or = 10 cm.
  • Assuming a pretest probability of malignancy of 5%, the likelihood ratios derived from this study yield a posttest probability of 10%, 19%, and 47% for cancer in adrenal cortical tumors > or = 4 cm, > or = 6 cm, and > or = 8 cm, respectively.
  • CONCLUSIONS: These data suggest that size is useful for predicting malignancy, and that at a size threshold of > or = 4 cm, the likelihood of malignancy doubles (to 10%) and it is more than ninefold higher for tumors > or = 8 cm (47%).
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Carcinoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Staging. Prevalence. Probability. Prognosis. Retrospective Studies. Risk Assessment. SEER Program / statistics & numerical data. Severity of Illness Index

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  • (PMID = 16500246.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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86. Wheeler YY, Burroughs F, Li QK: Fine-needle aspiration of a well-differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature. Diagn Cytopathol; 2009 Oct;37(10):748-54
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  • [Title] Fine-needle aspiration of a well-differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature.
  • WDPM may be difficult to diagnose and differentiate from benign reactive mesothelial cells and other malignant neoplasm on cytology specimens due to the presence of papillary or tubulopapillary clusters of tumor cells.
  • We report a case of a 63-year-old Asian male with a slowly growing left inguinal hernia mass for several years and a concurrent 8 cm mass in the peritoneal wall.
  • Tumor cells show minimal cytological atypia.
  • The differential diagnoses are broad and include reactive mesothelial cells, WDPM, and other malignant neoplasm.
  • It is important to recognize this entity in the differential diagnosis, because the clinical management of WDPM is quite different from that of malignant neoplasm.
  • [MeSH-major] Hernia, Inguinal / pathology. Inguinal Canal / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19373910.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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87. Kamiyama K, Usui S, Kimura M: [Thoracoscopic surgery combined with a supraclavicular approach for removing left superior mediastinal neurogenic tumor]. Kyobu Geka; 2009 Sep;62(10):880-3
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  • [Title] [Thoracoscopic surgery combined with a supraclavicular approach for removing left superior mediastinal neurogenic tumor].
  • Chest computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a left upper mediastinal mass at the Th1 to Th2 level, measuring 30 mm in size, which was suspected to be a neurogenic tumor.
  • Surgical removal of the tumor using thoracoscopic procedure through 3 chest ports combined with a supraclavicular approach was successfully performed.
  • A pathological examination revealed the tumor to be benign neurilemmoma.
  • [MeSH-major] Mediastinal Neoplasms / surgery. Neurilemmoma / surgery

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  • (PMID = 19764493.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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88. Kondo T, Kajimoto S, Okuda H, Toma H, Tanabe K: A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. Int J Urol; 2006 Jun;13(6):827-8
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  • [Title] A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery.
  • Granular cell tumor is a benign neoplasm which frequently occurs in the oral cavity, skin, and subcutaneous tissue.
  • Granular cell tumor of the bladder is an extremely rare disease, and only nine cases have been reported.
  • We present here an additional case of granular cell tumor occurring in the bladder.
  • Unlike the other tumors reported, this tumor extruded into the Retzius' cavity.
  • Therefore, the tumor was successfully excised through extraperitoneal laparoscopic surgery.
  • The small tumor located in Retzius' cavity could be managed with extraperitoneal laparoscopic surgery.
  • [MeSH-major] Granular Cell Tumor / therapy. Laparoscopy. Urinary Bladder Neoplasms / therapy

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  • (PMID = 16834673.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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89. Liu CL, Lai PL, Jung SM, Liao CC: Thoracic ossified meningioma and osteoporotic burst fracture: treatment with combined vertebroplasty and laminectomy without instrumentation: case report. J Neurosurg Spine; 2006 Mar;4(3):256-9
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  • Although spinal meningioma is a common benign neoplasm, the ossified variant is rare.
  • The tumor was completely removed by T10-11 laminectomy and transpedicular vertebroplasty was performed.
  • [MeSH-major] Laminectomy / methods. Meningeal Neoplasms / complications. Meningeal Neoplasms / surgery. Meningioma / complications. Meningioma / surgery. Spinal Neoplasms / complications. Spinal Neoplasms / surgery

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  • (PMID = 16572627.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Yoo KH, Kim BJ, Rho YK, Lee JW, Kim YJ, Kim MN, Song KY: A case of diffuse neurofibroma of the scalp. Ann Dermatol; 2009 Feb;21(1):46-8
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  • A neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann cells, perineural cells, and endoneurial fibroblasts.
  • Neurofibromas can involve any site on the body skin.
  • We present a case of a 10-year-old boy who had a diffuse neurofibroma on the scalp.

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  • [Cites] Histopathology. 1988 Aug;13(2):181-9 [3169686.001]
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  • (PMID = 20548855.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883368
  • [Keywords] NOTNLM ; Diffuse neurofibroma / Scalp
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91. Zhu HN, Yu JP, Luo J, Jiang YH, Li JQ, Sun WY: Gastric adenomyoma presenting as melena: a case report and literature review. World J Gastroenterol; 2010 Apr 21;16(15):1934-6
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  • Gastric adenomyoma (AM) is a rare benign tumor characterized by gland-like structures embedded within a smooth muscle stroma.
  • We report a case of a 68-year-old man with gastric AM admitted to our hospital for melana.
  • Although gastric AM is rare, it should be considered in differential diagnosis of extramucosal gastric tumor.
  • [MeSH-major] Adenomyoma / diagnosis. Adenomyoma / therapy. Melena / diagnosis. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Endoscopy / methods. Endoscopy, Gastrointestinal / methods. Humans. Microscopy / methods. Muscle, Smooth / pathology

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  • (PMID = 20397275.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 11
  • [Other-IDs] NLM/ PMC2856838
  • [Keywords] NOTNLM ; Adenomyoma / Endoscopic examination / Histopathology / Melana / Stomach
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92. Joshi D, Gangane N, Kishore S, Vagha S: Unusual histological presentation in neurofibromas: Two case reports. Cases J; 2008;1(1):188
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands.
  • The epithelial component was benign in this case.

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  • (PMID = 18823533.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2565668
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93. Garnacho Saucedo GM, Moreno Jiménez JC, Jiménez Puya R, Rodríguez Bujaldon A: Therapeutic Hotline: Topical glycopyrrolate: a successful treatment for craniofacial hyperhidrosis and eccrine hidrocystomas. Dermatol Ther; 2010 Jan-Feb;23(1):94-7
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  • Eccrine hidrocystoma is a benign tumor derived from eccrine sudoriparous glands.
  • Multiple hidrocystomas are unusual and have been associated with Graves' disease, Parkinson's disease, and idiopathic craniofacial hyperhidrosis.
  • [MeSH-major] Eyelid Neoplasms / drug therapy. Glycopyrrolate / therapeutic use. Hidrocystoma / drug therapy. Hyperhidrosis / drug therapy. Muscarinic Antagonists / therapeutic use. Sweat Gland Neoplasms / drug therapy

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  • (PMID = 20136914.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Muscarinic Antagonists; V92SO9WP2I / Glycopyrrolate
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94. Smolka W, Eggensperger N, Stauffer-Brauch EJ, von Bredow F, Lizuka T: Pleomorphic adenoma in an atypical location near the temporomandibular joint: a case report. Quintessence Int; 2007 May;38(5):417-21
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  • The tumor was solitary, closely attached to the capsule of the TMJ and superior to the parotid gland, with clear demarcation.
  • Clinically, the tumor resembled TMJ pathology, but MRI examination led to diagnosis of a benign tumor attached to the TMJ.
  • This report shows that pleomorphic adenoma can be a possible diagnosis for lesions at the joint capsule.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17568841.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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95. De Padua M, Gupta N, Broor SL, Govil D: Duodenal angiomyolipoma: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):568-9
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  • Angiomyolipoma is a benign neoplasm, the most common site being the kidney.
  • [MeSH-major] Angiomyolipoma / diagnosis. Duodenum / pathology. Intestinal Neoplasms / diagnosis

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  • [CommentIn] Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):859 [21045449.001]
  • (PMID = 17883138.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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96. Karabakhtsian R, Heller D, Hameed M, Bethel C: Periosteal chondroma of the rib--report of a case and literature review. J Pediatr Surg; 2005 Sep;40(9):1505-7
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  • [Title] Periosteal chondroma of the rib--report of a case and literature review.
  • Periosteal chondroma is a rare benign tumor of hyaline cartilage.

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  • (PMID = 16150361.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Soikkeli J, Lukk M, Nummela P, Virolainen S, Jahkola T, Katainen R, Harju L, Ukkonen E, Saksela O, Hölttä E: Systematic search for the best gene expression markers for melanoma micrometastasis detection. J Pathol; 2007 Oct;213(2):180-9
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  • We performed genome-wide gene expression analyses of melanoma lymph node micrometastases and macrometastases, and of primary melanomas and benign naevi, to characterize the early metastatic cells molecularly and to disclose the best diagnostic markers and rational targets for therapy.
  • In a prospective study of 160 patients, our graded MLANA and TYR RT-PCR analyses disclosed clinically significant metastases, as assessed by disease recurrence, better than histological and immunohistochemical examinations.
  • Furthermore, SPP1 and PRAME proved valuable as melanoma-specific markers capable of differentiating melanoma cells from benign naevi in the sentinel lymph nodes.
  • Most molecular traits of the micrometastases were already present in the primary tumours, suggesting that micrometastasis to sentinel lymph nodes is a fairly non-selective process.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Melanoma / diagnosis. Melanoma / secondary
  • [MeSH-minor] Antigens, Neoplasm / genetics. Antigens, Neoplasm / metabolism. Diagnosis, Differential. Humans. Lymphatic Metastasis. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Nevus / diagnosis. Oligonucleotide Array Sequence Analysis / methods. Osteopontin / genetics. Osteopontin / metabolism. Prospective Studies. Reverse Transcriptase Polymerase Chain Reaction / methods. Sentinel Lymph Node Biopsy. Skin Neoplasms / metabolism

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  • (PMID = 17891747.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / PRAME protein, human; 0 / SPP1 protein, human; 106441-73-0 / Osteopontin
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98. Chung SW, Kwon SY, Jung KY, Woo JS: Synchronous double primary cancers of the unilateral parotid gland. Acta Otolaryngol; 2007 Feb;127(2):209-12
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  • Synchronous parotid neoplasms, especially synchronous neoplasms of two separate and histologically different types, are extremely uncommon.
  • A review of the literature revealed that most reported cases were either a combination of two distinct benign neoplasms or a benign neoplasm and another malignant tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17364354.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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99. Wouda RM, Chalkley MD, Fraser AR, Moses PA: Hepatic myelolipoma incarcerated in a peritoneopericardial diaphragmatic hernia in a cat. Aust Vet J; 2010 Jun;88(6):231-5
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  • Myelolipoma is an extremely rare benign tumour, composed of extramedullary haematopoietic cells and adipose tissue.
  • Myelolipomas are hypothesised to result from metaplastic alteration, rather than a neoplastic process, although this theory cannot be substantiated.

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  • (PMID = 20553572.001).
  • [ISSN] 1751-0813
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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100. Rogers L, Gilbert M, Vogelbaum MA: Intracranial meningiomas of atypical (WHO grade II) histology. J Neurooncol; 2010 Sep;99(3):393-405
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  • Atypical (WHO grade II) meningiomas occupy an intermediate risk group between benign (WHO grade I) and anaplastic (WHO grade III) meningiomas.
  • We will discuss the definition, diagnosis, and treatment of patients with atypical meningioma; review the current phase II cooperative trials; and draw attention to some questions timely for pre-clinical and clinical research.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Humans. Neoplasm Staging. Prognosis. World Health Organization

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  • (PMID = 20740303.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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