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1. Chow HY, Stepanova D, Koch J, Chernoff J: p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. PLoS One; 2010 Nov 02;5(11):e13791
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: NF2 is an autosomal dominant disease characterized by development of bilateral vestibular schwannomas and other benign tumors in central nervous system.
  • Loss of the NF2 gene product, Merlin, leads to aberrant Schwann cell proliferation, motility, and survival, but the mechanisms by which this tumor suppressor functions remain unclear.
  • In addition, xenografts of such cells form fewer and smaller tumors than do cells without Pak inhibition.
  • However, in tumors, loss of Pak activity does not reduce Erk or Akt activity, two signaling proteins that are thought to mediate Pak function in growth factor pathways.
  • CONCLUSIONS/SIGNIFICANCE: These results suggest that Pak functions in novel signaling pathways in NF2, and may serve as a useful therapeutic target in this disease.

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  • (PMID = 21072183.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA006927; United States / NCI NIH HHS / CA / R01 CA117884; United States / NCI NIH HHS / CA / CA117884
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2; EC 2.7.11.1 / p21-Activated Kinases
  • [Other-IDs] NLM/ PMC2970553
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2. Arthurs BJ, Lamoreaux WT, Giddings NA, Fairbanks RK, Mackay AR, Demakas JJ, Cooke BS, Lee CM: Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature. World J Surg Oncol; 2009;7:100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Vestibular schwannomas, also called acoustic neuromas, are benign tumors of the vestibulocochlear nerve.
  • Patients with these tumours almost always present with signs of hearing loss, and many also experience tinnitus, vertigo, and equilibrium problems.
  • Following diagnosis with contrast enhanced MRI, patients may choose to observe the tumour with subsequent scans or seek active treatment in the form of microsurgery, radiosurgery, or radiotherapy.
  • Unfortunately, definitive guidelines for treating vestibular schwannomas are lacking, because of insufficient evidence comparing the outcomes of therapeutic modalities.We present a contemporary case report, describing the finding of a vestibular schwannoma in a patient who presented with dizziness and a "clicking" sensation in the ear, but no hearing deficit.
  • We discuss the diagnosis and patient's decision-making process, which led to treatment with Gamma Knife radiosurgery.

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  • (PMID = 20021676.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803477
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3. Papadogeorgakis N, Petsinis V, Goutzanis L, Kostakis G, Alexandridis C: Parapharyngeal space tumors: surgical approaches in a series of 13 cases. Int J Oral Maxillofac Surg; 2010 Mar;39(3):243-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parapharyngeal space tumors: surgical approaches in a series of 13 cases.
  • Tumors originating in the parapharyngeal space are rare; they comprise approximately 0.5% of head and neck tumors.
  • Most (70-80%) are benign and the most frequent origins are salivary and neurogenic.
  • The aim of this study is to present the surgical procedures used for the treatment of 13 patients with parapharyngeal space tumors; 11 of them were suffering from benign tumors (the most frequent being pleomorphic adenoma; 8 cases) and 2 from malignant lesions.
  • The type of surgical approach was dictated by the type of the lesion (malignant or benign), the exact location, the size, the vascularity and the relation of the tumor to the neck neurovascular bundle.
  • In all cases the selected surgical approach allowed the complete resection of the tumor, obtaining clear margins in cases of malignancy, without adding to the patient's preoperative morbidity.
  • It was concluded that the surgical approach to the parapharyngeal space tumors must be adjusted to the tumor characteristics and be as wide is necessary to achieve its complete removal with safety.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma, Pleomorphic / surgery. Adult. Aged. Biopsy, Fine-Needle. Deglutition Disorders / diagnosis. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lip / surgery. Magnetic Resonance Imaging. Male. Mandible / surgery. Middle Aged. Mouth / surgery. Neck / surgery. Osteotomy / classification. Osteotomy / methods. Postoperative Complications. Radiotherapy, Adjuvant. Sarcoma, Synovial / surgery. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20005672.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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4. Zhi L, Bing L, Yang L, Bo-ning L, Quan H: Cystic papillary meningioma with subarachnoid dissemination: a case report and review of the literature. Pathol Res Pract; 2009;205(8):582-7
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  • Meningiomas usually present as benign tumors corresponding to WHO grade I.
  • The tumor exhibits a marked peritumoral cyst, with contrast enhancement on magnetic resonance imaging (MRI) in accordance with type 2 of Zee's classification of cystic meningioma.
  • Histologically, the tumor displays a classical perivascular pseudopapillary pattern with focal necrosis and subarachnoid space dissemination.
  • Tumor cells are diffusely positive for epithelial membrane antigen (EMA) and vimentin, but lack immunoreactivity for cytokeratin (CK) and glial fibrillary acidic protein (GFAP).
  • MIB-1 labeling is high, accounting for 5% of tumor focally.
  • A diagnosis of primary intraventricular cystic papillary meningioma with subarachnoid space dissemination (WHO grade III) was made.
  • In addition, the biological behavior and the clinical outcome of this tumor are also discussed.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Cysts / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Magnetic Resonance Imaging. Mucin-1 / metabolism. Neoplasm Staging. Treatment Outcome. Vimentin / metabolism. Young Adult

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  • (PMID = 19307065.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Vimentin
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5. De Oliveira Junior PA, Moreira A, Brum M, Chaves A, Santos FA, Groppo FC: Modified surgical approach for removal of an ivory osteoma in the paranasal sinus. A case report. Minerva Stomatol; 2008 Mar;57(3):127-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteomas are benign tumors that consist mainly of mature compact or cancellous bone.
  • The most common site in maxillofacial complex is the mandible, particularly the angle, followed by sinuses.
  • After tumor removal and drainage of frontal and ethmoidal sinuses, the bone flap was repositioned using titanium microplates and screws.
  • [MeSH-major] Osteoma / surgery. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 18427381.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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6. Arabi Mianroodi AA, Sigston EA, Vallance NA: Frozen section for parotid surgery: should it become routine? ANZ J Surg; 2006 Aug;76(8):736-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The role of fine-needle aspiration (FNA) in salivary gland lesions as a preoperative diagnosis has always been under scrutiny.
  • Several studies have shown that frozen section (FS) is accurate for pathological diagnosis and decision-making during the surgery.
  • RESULTS: Eighty-five parotid tumours had been removed.
  • FS was able to differentiate benign tumours from malignant with 100% accuracy (30 cases).
  • [MeSH-major] Biopsy, Fine-Needle. Frozen Sections. Parotid Diseases / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16916397.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
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7. Starkov IuG, Vishnevskiĭ VA, Shishin KV, Solodina EN, Domarev LV, Kobesova TA: [Laparoscopic procedures in focal lesions of the liver]. Khirurgiia (Mosk); 2006;(2):4-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fifty-four patients had operations for non-parasitic cysts of the liver and cystic disease.
  • Polycystic disease of the liver was in 8 patients.
  • Laparoscopic cryodestruction of benign tumors and hepatic metastases was performed in 3 patients including in combination with atypical marginal resection in 2 cases.
  • Ultrasonic examination revealed no recurrences of the disease.

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  • (PMID = 16715976.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 16
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8. Zhang W, Hart J, McLeod HL, Wang HL: Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms. Am J Clin Pathol; 2005 Jul;124(1):11-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms.
  • We immunohistochemically examined 75 human colorectal neoplasms (adenoma, 27; adenocarcinoma, 24; neuroendocrine carcinoma, 24) for the expression of activator protein (AP)-1 family proteins.
  • JunB also was overexpressed in these tumors but with a predominantly cytoplasmic staining pattern.
  • Expression levels of JunD and c-Fos were high in nonneoplastic colorectal epithelial cells and remained so in neoplasms.
  • FosB was undetectable in nonneoplastic and neoplastic colorectal tissues.
  • Hierarchical clustering separated the majority of malignant from benign tumors based on AP-1 expression patterns.
  • AP-1 transcription factor family members are expressed differentially in nonneoplastic and neoplastic colorectal tissues.
  • Overexpression of Fra-2 may participate in tumor progression.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Neuroendocrine / metabolism. Colorectal Neoplasms / metabolism. Epithelial Cells / metabolism. Transcription Factor AP-1 / biosynthesis

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  • (PMID = 15923159.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM63340
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-fos; 0 / Proto-Oncogene Proteins c-jun; 0 / Transcription Factor AP-1; 0 / fos-related antigen 1
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9. Hauke S, Leopold S, Schlueter C, Flohr AM, Murua Escobar H, Rogalla P, Bullerdiek J: Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene. Biochim Biophys Acta; 2005 May 25;1729(1):24-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chromosomal rearrangements of the HMGA2 locus belong to the most common aberrations in human benign tumors.
  • RT-PCR-based expression studies of 4 of these HMGA2 transcripts revealed a co-expression with the "wild-type" HMGA2a in tumor samples as well as in normal tissues.
  • In silico analyses have been performed showing a high homology to well-established consensus sequences for the 3' splice acceptor site, the branch site, and poly(A) signal.
  • [MeSH-major] Alternative Splicing. Cell Transformation, Neoplastic / genetics. Gene Expression Regulation, Neoplastic. HMGB3 Protein / genetics. Introns / genetics. Neoplasms / genetics

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  • (PMID = 15882911.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / HMGB3 Protein; 0 / RNA Splice Sites
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10. Hemalata M, Kusuma V, Sruthi P: Ovarian lipoleiomyoma: a rare benign tumour. J Clin Pathol; 2007 Aug;60(8):939-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian lipoleiomyoma: a rare benign tumour.
  • [MeSH-major] Leiomyoma / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 17660338.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1994510
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11. Miyake M, Tateishi U, Maeda T, Arai Y, Hasegawa T, Sugimura K: Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT. Radiat Med; 2006 Feb;24(2):154-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT.
  • Bronchial granular cell tumor is an uncommon benign tumor that causes pulmonary complications due to obstruction of the airways.
  • [MeSH-major] Bronchial Neoplasms / complications. Granular Cell Tumor / complications. Lung Diseases, Obstructive / etiology

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  • (PMID = 16715680.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Li H, Yang SX, Wang B: [Study on cases of nasal tumors treated by dermatologic surgery: analysis of 63 cases]. Beijing Da Xue Xue Bao; 2006 Oct 18;38(5):519-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Study on cases of nasal tumors treated by dermatologic surgery: analysis of 63 cases].
  • OBJECTIVE: To study 63 cases of nasal tumors treated by dermatologic surgery, and analyze their generality and characters.
  • The other cases were benign tumors.
  • At the same time, the differentiation of applying complex close was obvious between malignant tumors and benign tumors.
  • CONCLUSION: Skin cancers and benign tumors usually occur on the nose, so it is very important to master the techniques of plastic surgery to repair the defects of nose, besides removing tumors perfectly by the classical way of dermatologic surgery, Mohs Micrographic Surgery.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Nose / surgery. Nose Neoplasms / surgery. Skin Neoplasms / surgery

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  • (PMID = 17068627.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Lima SS, Soares AF, de Amorim RF, Freitas Rde A: [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases]. Braz J Otorhinolaryngol; 2005 May-Jun;71(3):335-40
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  • [Title] [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases].
  • [Transliterated title] Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos.
  • AIM: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, STUDY DESIGN: Historic cohort.
  • The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis.
  • RESULTS: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant.
  • Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%).
  • The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women.
  • CONCLUSION: The data demonstrate that epidemiology profile of studied neoplasms corroborated the majority researched literature.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16446938.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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14. Avci E, Oztürk A, Baba F, Torun F, Karabağ H, Yücetaş S: Desmoplastic infantile ganglioglioma: case report. Turk J Pediatr; 2008 Sep-Oct;50(5):495-9
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  • These tumors are benign tumors of childhood that become symptomatic when they reach giant sizes.
  • [MeSH-major] Brain Neoplasms / diagnosis. Ganglioglioma / diagnosis
  • [MeSH-minor] Cranial Fossa, Anterior. Craniotomy / methods. Diagnosis, Differential. Humans. Infant. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed


15. Karlberg N, Karlberg S, Karikoski R, Mikkola S, Lipsanen-Nyman M, Jalanko H: High frequency of tumours in Mulibrey nanism. J Pathol; 2009 Jun;218(2):163-71
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  • [Title] High frequency of tumours in Mulibrey nanism.
  • Mulibrey nanism (MUL) is a monogenic disorder with prenatal-onset growth failure, typical clinical characteristics, cardiopathy and tendency for a metabolic syndrome.
  • In this work, the frequency and pathology of malignant and benign tumours were analysed in a national cohort of 89 Finnish MUL patients aged 0.7-76 years.
  • The results show that the MUL patients have disturbed architecture with ectopic tissues and a high frequency of both benign and malignant tumours detectable in several internal organs.
  • Fifteen malignancies occurred in 13 patients (15%), seven of them in the kidney (five Wilms' tumours), three in the thyroid gland, two gynaecological cancers, one gastrointestinal carcinoid tumour, one neuropituitary Langerhans cell histiocytosis and one case of acute lymphoblastic leukaemia (ALL).
  • Tumours detected by radiology in the liver and other organs mainly comprised strongly dilated blood vessels (peliosis), vascularized cysts and nodular lesions.
  • Our findings show that MUL is associated with frequent malignant tumours and benign adenomatous and vascular lesions, as well as disturbed organ development.
  • [MeSH-major] Mulibrey Nanism / complications. Neoplasms / complications
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / pathology. Adult. Aged. Child. Child, Preschool. Cohort Studies. Female. Finland. Heart Neoplasms / complications. Heart Neoplasms / pathology. Humans. Infant. Kidney Neoplasms / complications. Kidney Neoplasms / pathology. Liver Neoplasms / complications. Liver Neoplasms / pathology. Lung Neoplasms / complications. Lung Neoplasms / pathology. Male. Middle Aged. Pancreatic Neoplasms / complications. Pancreatic Neoplasms / pathology. Prevalence. Thyroid Neoplasms / complications. Thyroid Neoplasms / pathology. Wilms Tumor / complications. Wilms Tumor / pathology


16. Wu YH, Chen FY, Ouyang HY, Wang SM: [Clinical diagnosis of breast cancer with nonpalpable tumor]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Sep;33(9):861-4
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  • [Title] [Clinical diagnosis of breast cancer with nonpalpable tumor].
  • OBJECTIVE: To investigate the early diagnosis of breast cancer with nonpalpable tumor.
  • METHODS: Forty-six cases of clinical nonpalpable tumor were examined by mammography and sonography.The cases of nipple discharge were also examined by fiberoptic ductoscopy.
  • Of them, 34 diagnosed with breast cancer were found with nodus, calcification or confused structure, and so on, 5 were considered benign tumor, and 7 were not found lesion by mammography.
  • Thirty-one cases were diagnosed with breast cancer, 6 with benign tumor, and 9 were not found occupying lesion by sonography.
  • Early diagnosis rate of breast cancer can be elevated by signs of early breast cancer and combined examination of mammograply and sonography.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis

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  • (PMID = 18812668.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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17. Thitaikumar A, Mobbs LM, Kraemer-Chant CM, Garra BS, Ophir J: Breast tumor classification using axial shear strain elastography: a feasibility study. Phys Med Biol; 2008 Sep 7;53(17):4809-23
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  • [Title] Breast tumor classification using axial shear strain elastography: a feasibility study.
  • In this paper, we report a feasibility study on the utility of the axial-shear strain elastograms in the classification of in vivo breast tumor as being benign or malignant.
  • The study was performed using data sets obtained from 15 benign and 15 malignant cases that were biopsy proven.
  • The observers also outlined the tumor area on the corresponding sonogram, which was used to normalize the area of the axial-shear strain region.
  • First, the result indicates that the observers consistently ( approximately 82% of the cases) noticed the characteristic pattern of the axial-shear strain distribution data as predicted in the previous simulation studies, i.e. alternating regions of positive and negative axial-shear strain values around the tumor-background interface.
  • Second, the analysis of the result suggests that in approximately 57% of the cases in which the observers did not visualize tumor in the sonogram, the elastograms helped them to locate the tumor.
  • Feature values between 0.46 and 0.75 may result in an overlap between benign and malignant cases.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Elasticity Imaging Techniques / methods

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  • (PMID = 18701768.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Rydzewski B, Goździcka-Józefiak A, Sokalski J, Matusiak M, Durzyński L: [Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms]. Otolaryngol Pol; 2007;61(2):137-41
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  • [Title] [Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms].
  • There's a hypothesis, that it plays a significant role in middle ear chronic inflammations and neoplasm's.
  • The examination was carried on a group of 53 patients, 39 of which was suffering from granulation tissue chronic otitis media, 7-cholesteatomatous otitis media, 6--middle ear malignant neoplasm, and 1 middle and/or external ear benign neoplasm.
  • The material was postoperative tissue, like polyps, inflammatory granulation tissue, cholesteatoma masses and malignant neoplasm's tissue.
  • In every case of middle ear malignant neoplasm a presence of high-risk DNA Papilloma types 16 or 18 was confirmed.
  • CONCLUSIONS: The results has been compared with other authors examinations and it is claimed that they confirm the observation, that Human Papilloma Viruses may be a factor, that might play an important role in pathology of chronic otitis media and ear neoplasm's.
  • It is concluded, that differences in percentages of HPV presence in chronic inflammations (70%) and ear neoplasm's may be explained by viral co-infection during bacterial c. o. m.
  • Viral infection probably evolves carcinogenesis, which leads to a neoplastic growth.
  • [MeSH-major] Ear / virology. Ear Neoplasms / virology. Papilloma / genetics. Papilloma / virology. Papillomavirus Infections / diagnosis. Tumor Virus Infections / diagnosis. Tumor Virus Infections / virology

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  • (PMID = 17668798.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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19. Wojdas A, Jurkiewicz D: [The parotid gland's tumours in material of Otolaryngology Department of the Medical Military Institute between 2004-2008]. Otolaryngol Pol; 2009 Sep;63(7):73-5
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  • [Title] [The parotid gland's tumours in material of Otolaryngology Department of the Medical Military Institute between 2004-2008].
  • The parotid gland is the place where benign and malignant tumours may occur.
  • The aim of this work is to analyze operative treatment of parotid gland tumours performed in the years 2004-2008.
  • Between 2004-2008, 128 patients underwent surgical procedure caused by parotid gland tumour, including 72 women (56%) and 56 men (44%) aged between 12-80 (the average age was 49.1); the procedures were performed in the Otolaryngology Department of the Medical Military Institute.
  • The initial diagnosis was based on history and physical examination as well as additional examinations including standard ultrasound examination and BAC.
  • Our material includes benign tumours diagnosed in 113 patients (88.3%) and malignant ones in 15 patients (11.7%).
  • The most frequent parotid gland tumour is polymorphic adenoma (50%), the second most frequent one is lympho-adenoma (33.6%).
  • It was discovered that parotid gland tumours were predominantly benign tumours.
  • The most frequent type of parotid gland tumour was the polymorphic adenoma.
  • In the event of suspected malignant parotid gland tumour, it is necessary to conduct intraoperative histopathological examination.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery
  • [MeSH-minor] Academies and Institutes. Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 20564905.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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20. Buchner M, Bernd L, Zahlten-Hinguranage A, Sabo D: [Bone and soft-tissue tumors of the foot and ankle]. Chirurg; 2005 Apr;76(4):391-7
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  • [Title] [Bone and soft-tissue tumors of the foot and ankle].
  • BACKGROUND: This study reports the epidemiology of bone and soft-tissue tumors of the foot and ankle, presents therapy strategies, and evaluates mid-term clinicofunctional outcome after surgery for malignant tumors.
  • METHODS: Two hundred four patients with tumors of the foot and ankle were analyzed (163 benign and 41 malignant).
  • RESULTS: The most frequent tumors were exostosis, bone cyst, and osteoid osteoma for benign tumors and metastases and chondrosarcoma and Ewing's sarcoma for malignant tumors.
  • In more than 90% of the benign tumors, local resection could be carried out, whereas in malignant tumors, ablative procedures and arthrodeses were almost as common as limb- and joint-sparing techniques.
  • However, follow-up revealed good functional results and a 5-year survival rate of 84% for patients with primary malignant tumors.
  • CONCLUSION: Tumors of the foot and ankle require a thorough therapeutic strategy.
  • [MeSH-major] Ankle Joint / surgery. Bone Neoplasms / surgery. Foot / surgery. Foot Diseases / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Amputation. Arthrodesis. Bone Transplantation. Child. Child, Preschool. Female. Follow-Up Studies. Fracture Fixation, Internal. Fractures, Spontaneous / diagnosis. Fractures, Spontaneous / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 15526178.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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21. Li NY, Zhou XJ, Jin XZ, Meng K, Ma HH, Zheng XG, Jiang SJ, Sun GQ: [A clinicopathologic study of dysembryoplstic neuroepithelial tumor]. Zhonghua Bing Li Xue Za Zhi; 2005 Sep;34(9):561-5
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  • [Title] [A clinicopathologic study of dysembryoplstic neuroepithelial tumor].
  • OBJECTIVE To study the clinicopathologic features, radiologic findings, treatment modalities and prognosis of dysembryoplastic neuroepithelial tumor (DNT).
  • On magnetic resonance imaging (MRI) study, the tumor was hypodense on T1 and hyperdense on T2.
  • Ten cases were treated by complete surgical excision and the remaining 8 tumors were partially excised.
  • None of the cases showed tumor recurrence after operation.
  • Histologically, all tumors demonstrated a multinodular architecture and were intracortical in location, sometimes with extension into the white matter.
  • The characteristic "glioneuronal constituent" was an essential feature for making the diagnosis of DNT.
  • The tumor was formed by an admixture of oligodendrocyte-like cells, mature neurons and astrocytes, with obvious microcystic changes.
  • CONCLUSIONS: DNT is a benign tumor (corresponding to WHO grade I) that can be cured by surgical excision, despite sometimes incomplete tumor removal.
  • A correct diagnosis of this entity requires thorough understanding of the clinical, radiologic, histologic and immunohistochemical features.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebral Cortex / pathology. Neoplasms, Neuroepithelial / pathology. Oligodendroglia / pathology

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  • (PMID = 16468305.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neurofilament Proteins; 0 / S100 Proteins; 0 / Synaptophysin
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22. Suwała P, Wilczyński K, Barnaś S, Prudlak E: [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma]. Otolaryngol Pol; 2009 Sep;63(7):89-92
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  • [Title] [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma].
  • AIM OF THE WORK: The authors present unusually rare case primary multiple synchronicus benign tumor of the ipsilateral parotid gland: oncocytoma and Warthin's tumor, which is rare among occasionally occurred multiple tumors with different histology in the salivary glands.
  • MATERIAL AND METHOD: A 71-year-old man presented with the tumor in the right parotid gland.
  • The preoperative ultrasonography and macroscopic analysis of the removed parotid gland tissue revealed only one tumor recognised histopathologically as adenolimphoma, but upon histopathological examination Warthin's tumor proved to coexist with oncocytoma.
  • RESULTS AND CONCLUSIONS: In the ultrasonography examination some salivary glands tumors may not be recognised.
  • The histopathological examination is the ultimate method in recognising tumors, which are not detected in the preoperative diagnosis.
  • The superficial parotidectomy protects from the recrudescence of the superficial lobe of the parotid gland tumors.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20564910.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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23. Themistocleous GS, Chloros GD, Benetos IS, Efstathopoulos DG, Gerostathopoulos NE, Soucacos PN: Osteoid osteoma of the upper extremity. A diagnostic challenge. Chir Main; 2006 Jun;25(2):69-76
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  • Osteoid osteomas are benign tumors that may commonly mimic other entities in the upper extremity.
  • The purpose of this study is to describe the clinical and imaging features of osteoid osteomas involving the upper extremity, highlight the difficulties in the diagnosis in the various areas and propose a diagnostic workup.
  • The average duration of symptoms before definite diagnosis was 18 months (range 2-62).
  • Radiographs alone were sufficient to establish the diagnosis of osteoid osteoma in 32 cases.
  • Bone scans identified a "hot spot" in 16 patients without previous radiographic evidence of a lesion and furthermore, computed tomography was performed in 32 patients to assist in the intraosseous localization of the lesion, and in the pre-operative planning.
  • All patients underwent operative excision of the lesion and the diagnosis was confirmed by histology.
  • Osteoid osteoma of the upper extremity often mimics other etiologies and the complex anatomy of the upper extremity, as well as the tendency of patients to relate their symptoms to trauma are factors that easily lead to misdiagnosis or delay in the diagnosis.
  • A high index of suspicion is essential and the diagnosis is based on an accurate clinical assessment and careful selection of imaging studies.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bones of Upper Extremity / pathology. Osteoma, Osteoid / diagnosis

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  • (PMID = 16841767.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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24. Mazlina S, Shiraz MA, Hazim MY, Amran AR, Zulkarnaen AN, Wan Muhaizan WM: Sinonasal inverted papilloma with malignant transformation in the middle ear: a multicentric origin? J Laryngol Otol; 2006 Jul;120(7):597-9
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  • Inverted papilloma is a rare, benign tumour representing only 0.5 to 4 per cent of all sinonasal neoplasms; its involvement of the middle ear is extremely rare.
  • [MeSH-major] Ear Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology. Papilloma, Inverted / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic. Ear, Middle / pathology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Tomography, X-Ray Computed

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  • (PMID = 16672089.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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25. Gu W, Sun LH, Fang SR, Ma JY, Zhang AP, Chen L: [Clinical analysis of the rare causes of hemoptysis: a report of 4 cases]. Zhonghua Jie He He Hu Xi Za Zhi; 2007 May;30(5):343-6
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  • OBJECTIVE: To improve the diagnosis of hemoptysis caused by rare lung diseases.
  • For PH, a benign tumor, the diagnosis was based on the history and radiography examination, and operation was the choice for therapy.
  • The diagnosis of PPH was firstly evaluated by chest film and echocardiogram, and the final diagnosis relied on right cardiac catheter examination.
  • The correct diagnosis and therapy rely on comprehensive thinking, careful history collection and reasonable examinations.

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  • (PMID = 17651639.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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26. Sato T, Harao M, Nakano S, Jotsuka T, Suda N, Yamashita J: Circulating tumor cells detected by reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA: distinguishing follicular thyroid carcinoma from adenoma. Surgery; 2005 May;137(5):552-8
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  • [Title] Circulating tumor cells detected by reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA: distinguishing follicular thyroid carcinoma from adenoma.
  • BACKGROUND: We prospectively tested whether circulating tumor cells could be detected in peripheral blood of patients with thyroid tumors by a reverse transcription-polymerase chain reaction (RT-PCR) to detect carcinoembryonic antigen (CEA) messenger RNA (mRNA).
  • METHODS: We assayed for CEA mRNA by RT-PCR in peripheral blood sampled before and 2 to 3 weeks after curative surgery for thyroid tumors in 121 patients.
  • Of 121 preoperative samples from patients with thyroid tumor, 6 were positive (5.0%).
  • Preoperative frequencies of CEA mRNA positivity in benign tumor, papillary carcinoma, follicular variant papillary carcinoma, minimally invasive follicular carcinoma, and widely invasive follicular carcinoma were 0%, 0%, 0%, 44.4% (4/9), and 50.0% (2/4), respectively.
  • CONCLUSIONS: RT-PCR detection of tumor cells in preoperative blood often can distinguish malignant from benign follicular thyroid tumors.
  • [MeSH-major] Adenoma / metabolism. Carcinoembryonic Antigen / metabolism. Carcinoma / metabolism. Goiter, Nodular / metabolism. Neoplastic Cells, Circulating / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adult. Case-Control Studies. Diagnosis, Differential. Follow-Up Studies. Humans. Middle Aged. Prospective Studies. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 15855928.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / RNA, Messenger
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27. Castillo Lario MC, Carro Alonso B, Gimeno Peribáñez MJ, Freile García E, Villavieja Atance JL: [Giant right adrenal myelolipoma]. Arch Esp Urol; 2006 Nov;59(9):911-3
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  • OBJECTIVE: Adrenal myelolipoma is a rare benign tumor, well limited, variable in size, composed of fatty and hematopoietic tissues, the finding of which is usually incidental.
  • METHODS: We report the case of a 57-year-old male admitted to the hospital with acute abdominal pain.
  • Pathologic findings: benign tumor, encapsulated, with a mixture of mature fatty tissue and hematopoietic cells.
  • CONCLUSIONS: The presence of fat within an adrenal mass is essential for the diagnosis.
  • Differential diagnosis should be done with all adrenal tumors with a fat component.
  • When no radiological diagnosis is made, pathologic confirmation is necessary.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Myelolipoma / diagnosis

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  • (PMID = 17190217.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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28. Rubin G, Wolovelsky A, Rinott M, Rozen N: Osteoid osteoma of the hamate: an unusual cause of ulnar-sided wrist pain. Orthopedics; 2010 Jul;33(7):513
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  • Osteoid osteoma is a benign skeletal neoplasm of unknown etiology that is composed of osteoid and woven bone.
  • Its incidence is 11% of benign tumors and 3% of all primary bone tumors, with 6% to 13% of all cases occurring in the hand.
  • Osteoid osteoma of the hamate can produce ulnar-sided wrist pain in the dorsal or volar aspect of the wrist, depending on the location of the tumor in the bone.
  • Most of the tumors will produce dorsal pain.
  • A tumor located in the hook will produce volar pain.
  • [MeSH-major] Arthralgia / diagnosis. Bone Neoplasms / pathology. Hamate Bone / pathology. Osteoma, Osteoid / pathology. Ulna / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20608627.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Rieker RJ, Schirmacher P, Schnabel PA, Moser K, Hoffmann H, Dienemann H, Pfannschmidt J: Thymolipoma. A report of nine cases, with emphasis on its association with myasthenia gravis. Surg Today; 2010;40(2):132-6
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  • PURPOSE: Thymolipomas are rare tumors of the anterior mediastinum accounting for up to 9% of all thymic tumors.
  • These tumors are associated with autoimmune diseases in up to 50% of the patients, including myasthenia gravis, aplastic anemia, hypogammaglobulinemia, lichen planus, and Graves' disease.
  • These tumors with a fatty appearance also can arise in older patients with autoimmune disease.
  • RESULTS: Seven patients initially presented with myasthenia gravis, and therefore they underwent a resection of the thymus, even though imaging techniques did not reveal a tumor in any of the cases.
  • Another patient showed no symptoms of autoimmune disease for 20 years, and though cardiomegaly was suspected, further investigation revealed a thymolipoma.
  • CONCLUSIONS: Thymolipomas are benign tumors that show an excellent outcome.
  • Patients with autoimmune disease symptoms occasionally show an improvement of the symptoms after a resection of the tumors.
  • [MeSH-major] Lipoma / surgery. Myasthenia Gravis / complications. Myasthenia Gravis / surgery. Thymectomy. Thymus Neoplasms / surgery

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  • (PMID = 20107952.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. Gurates B, Parmaksiz C, Kilic G, Celik H, Kumru S, Simsek M: Treatment of symptomatic uterine leiomyoma with letrozole. Reprod Biomed Online; 2008 Oct;17(4):569-74
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  • Uterine leiomyomas are the most common benign tumours of the female genital tract, often necessitating hysterectomy.
  • The purpose of this study was to evaluate the effects of the non-steroidal aromatase inhibitor letrozole on uterine leiomyomas and on bone metabolism.
  • [MeSH-major] Leiomyoma / drug therapy. Nitriles / therapeutic use. Triazoles / therapeutic use. Uterine Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Aromatase Inhibitors / therapeutic use. Bone Density / drug effects. Bone and Bones / drug effects. Bone and Bones / metabolism. Female. Follicle Stimulating Hormone / blood. Humans. Luteinizing Hormone / blood. Organ Size / drug effects. Ovary / drug effects. Ovary / pathology. Pilot Projects. Tumor Burden / drug effects. Uterus / drug effects. Uterus / pathology

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  • (PMID = 18854113.001).
  • [ISSN] 1472-6491
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Aromatase Inhibitors; 0 / Nitriles; 0 / Triazoles; 7LKK855W8I / letrozole; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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31. Kaznowska E, Przybyłowska K, Kulig A: The -173 G/C polymorphism of the promoter region macrophage migration inhibitory factor gene is not associated with incidence of pulmonary hamartoma. Pol J Pathol; 2007;58(3):189-92
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  • Hamartomas are the third most common cause of solitary pulmonary nodule and the most common benign tumors of lung.
  • [MeSH-minor] Adult. Aged. Female. Genetic Predisposition to Disease. Genotype. Humans. Incidence. Male. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 18074864.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Macrophage Migration-Inhibitory Factors
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32. O'Malley BW Jr, Weinstein GS: Robotic skull base surgery: preclinical investigations to human clinical application. Arch Otolaryngol Head Neck Surg; 2007 Dec;133(12):1215-9
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  • OBJECTIVE: To develop a minimally invasive surgical technique for the treatment of parapharyngeal space and infratemporal fossa skull base neoplasms using the technical and optical advantages of robotic surgical instrumentation.
  • Based on the preclinical work, transoral robotic surgery (TORS) was then performed in February 2007 on 1 human patient with a parapharyngeal to infratemporal fossa cystic neoplasm as part of a large prospective human trial.
  • For the human surgical case, a TORS approach was evaluated on one side for a benign neoplasm.
  • PATIENTS: For the human clinical trial, a TORS approach was evaluated for a patient with a benign neoplasm of the parapharyngeal space and infratemporal fossa.
  • In the first known human surgical case, TORS was used to remove a parapharyngeal space and infratemporal fossa cystic neoplasm.
  • Robotic surgery for the skull base holds potential as a minimally invasive approach to skull base neoplasms; however, continued development and investigation is warranted in a prospective human clinical trial before final conclusions can be drawn as to the full advantages and limitations of this approach.
  • [MeSH-major] Endoscopes. Endoscopy / methods. Robotics / instrumentation. Skull Base Neoplasms / surgery
  • [MeSH-minor] Animals. Cysts / diagnosis. Cysts / surgery. Dogs. Equipment Design. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Mouth. Treatment Outcome

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  • (PMID = 18086962.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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33. Stewart ZA, Hruban RH, Fishman EF, Wolfgang CL: Surgical management of giant Brunner's gland hamartoma: case report and literature review. World J Surg Oncol; 2009;7:68
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  • Brunner's gland hamartomas (BGH) are uncommon benign tumors of the duodenum forming mature Brunner's glands.
  • We report here an unusual case of a giant BGH that was not amenable to endoscopic or surgical local resection thus requiring a pancreaticoduodenectomy for extirpation.

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  • (PMID = 19725968.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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  • [Other-IDs] NLM/ PMC2749032
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34. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Non-specificity of clinical and radiological features of these maxillary lesions makes their diagnosis difficult.
  • The awareness of the spectrum of pathology related to maxillary swelling is essential for correct diagnosis and treatment.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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35. Benedict WJ Jr, Brown HG, Sivarajan G, Prabhu VC: Intraventricular schwannoma in a 15-year-old adolescent: a case report. Childs Nerv Syst; 2008 Apr;24(4):529-32
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  • INTRODUCTION: Schwannomas are benign tumors that originate from the myelin-forming Schwann cells of peripheral nerves or at the Obersteiner-Redlich zone of the vestibular division of the eighth cranial nerve.
  • DISCUSSION: This case report illustrates a right occipital horn schwannoma in a 15-year-old adolescent boy who was successfully treated with surgical resection and discusses the possible origins of the tumor in this unique location.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery

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  • (PMID = 18175126.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 13
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36. Alahyane A, Bounaim A, Jahid A, Janati IM: [Hibernoma of the forearm]. Chir Main; 2006 Sep;25(3-4):166-8
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  • [Transliterated title] Hibernome de l'avant-bras.
  • Hibernomas are rare benign tumours originating from the brown fat found in the foetus and animals that hibernate.
  • We report a case of hibernoma of the forearm, which is an unusual localization, and we review the diagnostic and therapeutic aspects of this of tumour whose main differential diagnosis is liposarcoma.
  • [MeSH-major] Forearm. Lipoma. Muscle Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Liposarcoma / diagnosis. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 17175806.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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37. Neumann V, Löseke S, Tannapfel A: [Medical insurance aspects of peritoneal tumors with particular attention to peritoneal mesotheliomas]. Med Klin (Munich); 2009 Oct 15;104(10):765-71
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  • [Title] [Medical insurance aspects of peritoneal tumors with particular attention to peritoneal mesotheliomas].
  • Malignant peritoneal mesotheliomas arise mainly in male patients and the median age of initial diagnosis is about 56 years.
  • The mean latency period between exposure and diagnosis of peritoneal mesothelioma ranges from 35 to 40 years and is comparable to that of pleural mesothelioma.
  • No significant evidence exists for the classification of well-differentiated papillary mesothelioma, solitary fibrous tumor, adenomatoid tumor, primary peritoneal serous borderline tumor, and benign multicystic mesothelioma as asbestos-associated tumors.
  • Except malignant mesotheliomas, the induction of other abdominal tumors is independent of an exposure to asbestos dust.
  • [MeSH-major] Asbestosis / epidemiology. Mesothelioma / epidemiology. National Health Programs / statistics & numerical data. Peritoneal Neoplasms / epidemiology
  • [MeSH-minor] Biopsy. Causality. Cross-Sectional Studies. Female. Germany. Humans. Insurance, Accident / legislation & jurisprudence. Insurance, Accident / statistics & numerical data. Male. Middle Aged. Peritoneum / pathology. Pleural Neoplasms / classification. Pleural Neoplasms / epidemiology. Pleural Neoplasms / etiology. Pleural Neoplasms / pathology. Risk Factors. Workers' Compensation / legislation & jurisprudence. Workers' Compensation / statistics & numerical data

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  • (PMID = 19856150.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 76
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38. Uppin SG, Sundaram C, Umamahesh M, Chandrashekar P, Rani YJ, Prasad VB: Lesions of the bones of the hands and feet: a study of 50 cases. Arch Pathol Lab Med; 2008 May;132(5):800-12
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  • RESULTS: The 50 lesions encountered included 23 (46.0%) infections/inflammatory lesions, 16 (32.0%) benign tumors, 6 (12.0%) malignant tumors, and 5 (10.0%) tumorlike lesions.
  • Giant cell tumor was the most common benign tumor.
  • Malignant tumors involved the nonphalangeal bones, with chondrosarcoma the most common.
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / pathology. Bone Cysts / radiography. Bone Neoplasms / pathology. Bone Neoplasms / radiography. Child. Female. Giant Cells / pathology. Humans. Male. Middle Aged. Osteomyelitis / pathology. Osteomyelitis / radiography. Periostitis / pathology. Periostitis / radiography. Retrospective Studies

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  • (PMID = 18466029.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Elsayed H, Traify R, McKeon D, Poullis M: An endobronchial lipoma: diagnosis remains a challenge. J Bronchology Interv Pulmonol; 2010 Jan;17(1):95-6
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  • [Title] An endobronchial lipoma: diagnosis remains a challenge.
  • Benign tumors of the endobronchial tree are rare, and among them endobronchial lipoma is the least common.
  • It is histologically benign in character but may cause bronchial obstruction.
  • We describe a case of a 68-year-old woman with an endobronchial lipoma arising in the left lower lobe bronchus who had been treated for frequent chest infections for the past 3 years.

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  • (PMID = 23168672.001).
  • [ISSN] 1944-6586
  • [Journal-full-title] Journal of bronchology & interventional pulmonology
  • [ISO-abbreviation] J Bronchology Interv Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Konstantinidis K, Theodoropoulos GE, Sambalis G, Georgiou M, Vorias M, Anastassakou K: Cystic lymphangioma of the small bowel in a woman at 15 weeks' gestation: laparoscopic approach. Surg Laparosc Endosc Percutan Tech; 2005 Aug;15(4):244-5
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  • Lymphangiomas are uncommon benign tumors, usually encountered early in childhood.
  • Here is described the case of a pregnant woman at 15 weeks' gestation with a symptomatic ileal small bowel lymphangioma that was approached laparoscopically.
  • This is the first reported laparoscopically assisted resection of a small bowel cystic lymphangioma during pregnancy.
  • [MeSH-major] Ileal Neoplasms / surgery. Lymphangioma, Cystic / surgery. Pregnancy Complications, Neoplastic / surgery

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  • (PMID = 16082316.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Hatanaka K, Kudo M, Minami Y, Maekawa K: Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies: comparison with contrast-enhanced CT. Oncology; 2008;75 Suppl 1:42-7
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  • [Title] Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies: comparison with contrast-enhanced CT.
  • OBJECTIVE: The purpose of this study was to assess the usefulness of Sonazoid-enhanced ultrasonography (US) in the diagnosis of hepatic malignancies in comparison with contrast-enhanced CT findings.
  • METHODS: A total of 74 patients with 113 hepatic tumors having or highly suspected of having malignancies were enrolled.
  • These hepatic nodules were diagnosed by typical findings of imaging such as contrast-enhanced CT, dynamic MRI or Sonazoid-enhanced US, tumor markers and histological examinations after surgical resection or biopsy.
  • RESULTS: 108 nodules were diagnosed as malignant tumors (hepatocellular carcinoma: n = 90; metastasis: n = 16; intrahepatic cholangiocarcinoma: n = 2) and the remaining five tumors were diagnosed as benign tumors (dysplastic nodules: n = 5).
  • Sonazoid-enhanced US correctly depicted the presence or absence of tumors in 74 patients, with a sensitivity of 95.4%, an accuracy of 94.7%, and a positive predictive rate of 99%.
  • CONCLUSION: Sonazoid-enhanced US has a higher sensitivity and accuracy for the diagnosis of hepatic malignancies than contrast-enhanced CT.
  • [MeSH-major] Contrast Media. Ferric Compounds. Iron. Liver Neoplasms / diagnosis. Oxides. Tomography, X-Ray Computed. Ultrasonography / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / diagnosis. Cholangiocarcinoma / diagnosis. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19092271.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 0 / Oxides; 0 / Sonazoid; E1UOL152H7 / Iron
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42. Wang B, Povoski SP, Cao X, Sun D, Xu RX: Dynamic schema for near infrared detection of pressure-induced changes in solid tumors. Appl Opt; 2008 Jun 1;47(16):3053-63
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  • [Title] Dynamic schema for near infrared detection of pressure-induced changes in solid tumors.
  • Differentiation among malignant tumors, benign tumors, and normal tissue is highly important in the diagnosis and treatment of many malignancies.
  • We have proposed a dynamic schema for noninvasive characterization of pressure-induced changes in solid tumors.
  • This hypothesis was tested by the evaluation of data generated from human tumor clinical testing and from animal tumor model testing.
  • In the human tumor clinical testing, a unified diagnostic criterion was derived that integrated the relative characteristics of tumor oxygen, hemoglobin, and hemoglobin dynamics.
  • By applying such a unified criterion, we were able to differentiate benign breast lesions and malignant breast tumors with high sensitivity and specificity within a subset of 14 suspicious breast lesions with similar size and depth characteristics.
  • In the animal testing, a stepped compression load was applied to the subcutaneous tumor deposit on an athymic NU/NU nude mouse model with subcutaneous xenograft BxPC-3 cancer.
  • Characteristic differences were observed between the premortem tumor and the postmortem tumor in terms of pressure-induced tumor structural and functional changes.
  • [MeSH-major] Breast Neoplasms / metabolism. Neoplasms / radiography. Optics and Photonics
  • [MeSH-minor] Animals. Compressive Strength. Disease Models, Animal. Hemoglobins / metabolism. Humans. Mice. Mice, Nude. Models, Statistical. Oxygen / metabolism. Pressure. Spectroscopy, Near-Infrared / methods. Time Factors

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  • (PMID = 18516127.001).
  • [ISSN] 0003-6935
  • [Journal-full-title] Applied optics
  • [ISO-abbreviation] Appl Opt
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; S88TT14065 / Oxygen
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43. Olivi G, Costacurta M, Maturo P, Docimo R: Removal of fibrous epulis with Er,Cr:YSGG laser: case report. Eur J Paediatr Dent; 2007 Sep;8(3):149-52
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  • BACKGROUND: Epulis is a benign tumour located in the area of the alveolar bone, periodontal ligament and marginal gingiva.
  • The histopathological examination confirmed the diagnosis of fibrous epulis.

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  • (PMID = 17919064.001).
  • [ISSN] 1591-996X
  • [Journal-full-title] European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry
  • [ISO-abbreviation] Eur J Paediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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44. Ahmad T, Naeem M, Ahmad S, Samad A, Nasir A: Fine needle aspiration cytology (FNAC) and neck swellings in the surgical outpatient. J Ayub Med Coll Abbottabad; 2008 Jul-Sep;20(3):30-2
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  • Tuberculous lymphadenitis was the commonest diagnosis (36%) followed by reactive/non-specific lymphadenitis (18%).
  • Other pathologies were malignant neoplasms (14%), cysts (10%), benign neoplasms (8%) and sialadenitis (6%).
  • CONCLUSION: It is concluded that tuberculous lymphadenitis is still the commonest condition in patients presenting with neck swellings followed by non-specific lymphadenitis and malignant neoplasms especially metastatic carcinoma.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Head and Neck Neoplasms / pathology. Outpatients. Salivary Gland Diseases / pathology. Tuberculosis, Lymph Node / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19610510.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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45. Huang P, Staerkel G, Sneige N, Gong Y: Fine-needle aspiration of pancreatic serous cystadenoma: cytologic features and diagnostic pitfalls. Cancer; 2006 Aug 25;108(4):239-49
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  • BACKGROUND: The preoperative diagnosis of pancreatic serous cystadenoma (SCA) is important because as a typically benign tumor it can be treated expectantly, whereas many other cystic tumors require excision.
  • This study examines the cytology, clinical and radiologic features, diagnostic accuracy of fine-needle aspiration (FNA), and potential pitfalls associated with this rare tumor.
  • Corresponding histology (14 tumors) and clinical/imaging findings were also evaluated.
  • Tumor cells formed loose clusters or monolayered sheets composed of cuboidal cells with indistinct cell borders and granular or clear cytoplasm that was often stripped from the nucleus.
  • Seven (25%) of the aspirates were initially classified as "consistent with SCA," 6 (21%) as "no malignant cells," 3 (11%) as "nondiagnostic specimen," 3 (11%) as "suspicious for malignancy," 3 (11%) as "rare atypical cells," and 6 (21%) as "probably or consistent with mucinous cystic neoplasm."
  • Features causing diagnostic difficulty were scant cellularity, papillary groups, nuclear atypia, and columnar cells mimicking those of mucinous neoplasms.
  • Familiarity with its morphologic spectrum, use of ancillary studies, and correlation with clinical/radiologic findings greatly improves diagnostic accuracy.
  • Contaminating GI epithelium and mucin should be distinguished from components of a mucinous neoplasm.
  • [MeSH-major] Biopsy, Fine-Needle. Cystadenoma, Serous / diagnosis. Pancreas / pathology. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • [Copyright] Copyright 2006 American Cancer Society.
  • (PMID = 16691573.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Cohen AB, Lessell S: Angiogenesis and pituitary tumors. Semin Ophthalmol; 2009 May-Jun;24(3):185-9
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  • [Title] Angiogenesis and pituitary tumors.
  • They are typically slow-growing and histologically benign tumors, but can become clinically destructive, invade adjacent structures, and recur after treatment.
  • Unlike many other tumors that become aggressive and appear to depend upon angiogenesis in the process, pituitary adenomas tend to do so through non-angiogenic means.
  • [MeSH-major] Neovascularization, Pathologic. Pituitary Neoplasms / blood supply
  • [MeSH-minor] Adenoma / blood supply. Adenoma / metabolism. Adenoma / pathology. Animals. Biomarkers, Tumor / biosynthesis. Blood Vessels / pathology. Humans. Neoplasm Invasiveness. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 19437356.001).
  • [ISSN] 1744-5205
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A
  • [Number-of-references] 22
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47. Kuczkowski J, Potocka M, Kobierska-Gulida G, Przewoźny T, Dubaniewicz-Wybieralska M: [Osteomas and exostoses of external auditory canal in material of Otolaryngology Department Medical University of Gdańsk]. Otolaryngol Pol; 2010 Nov-Dec;64(6):365-9
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  • INTRODUCTION: Osteomas and exostoses of the external auditory canal are benign tumours arising in bones, leading to its obstruction and causing hearing loss.
  • Histological examination confirmed benign overgrowth of compact and trabecular bone.
  • CONCLUSIONS: Osteomas are benign tumours leading to obstruction of the external auditory canal.
  • [MeSH-major] Bone Neoplasms / surgery. Ear Canal / surgery. Exostoses / surgery. Osteoma / surgery

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  • (PMID = 21302503.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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48. Gottwald L, Korczyński J, Góra E, Bieńkiewicz A: [Adnexal tumors after surgical treatment of colorectal cancer]. Ginekol Pol; 2008 Apr;79(4):259-63
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  • [Title] [Adnexal tumors after surgical treatment of colorectal cancer].
  • OBJECTIVE: The risk of metastatic ovarian tumor is significantly higher in case of women with a history of colorectal cancer.
  • DESIGN: The purpose of the study was to evaluate the clinical presentation and histopathology of adnexal tumors in case of female patients with a history of colorectal adenocarcinoma.
  • MATERIAL AND METHODS: A retrospective study on 13 women (each with a history of colorectal carcinoma, operated due to adnexal tumor between 2004 and 2007), has been conducted.
  • Subject characteristics, ultrasound, CT, serum tumor markers levels, histopathology and findings at surgery were analyzed.
  • RESULTS: Time distance between colorectal cancer surgery and ovarian tumor operation - measured in months -was shorter in cases of malignant neoplasms (10.13 +/- 3.98) than in benign tumors (26.2 +/- 19.37).
  • Ultrasound examination showed solid-cystic adnexal tumors in 8 malignant cases, and ovarian cysts in 5 benign conditions.
  • Unilateral adnexectomy only took place in one case of benign tumor and in one case of disseminated neoplasmatic disease.
  • CONCLUSIONS: When evaluating a patient with an adnexal tumor, a history of malignancy strongly suggests a metastatic nature.
  • The use of ultrasound associated with plasma levels of Ca 125, Ca 19-9 and CEA, represents a useful method of preoperative assessment of ovarian tumors.
  • [MeSH-major] Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. CA-125 Antigen / blood. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Female. Humans. Middle Aged. Neoplasm Staging. Poland. Retrospective Studies. Risk Assessment. Ultrasonography, Doppler, Color / methods

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  • (PMID = 18592863.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
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49. Klintworth N, Zenk J, Koch M, Iro H: Postoperative complications after extracapsular dissection of benign parotid lesions with particular reference to facial nerve function. Laryngoscope; 2010 Mar;120(3):484-90
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  • [Title] Postoperative complications after extracapsular dissection of benign parotid lesions with particular reference to facial nerve function.
  • OBJECTIVES/HYPOTHESIS: The desirable extent of surgical intervention for benign parotid tumors remains a matter of controversy.
  • For some time now, extracapsular dissection without exposure of the main trunk of the facial nerve has been favored as an alternative for the treatment of discrete parotid tumors.
  • METHODS: We performed a retrospective analysis of the data from patients in whom extracapsular dissection of a benign parotid tumor had been performed under facial nerve monitoring and as a primary intervention in our department between 2000 and 2008.
  • RESULTS: A total of 934 patients were operated on for a newly diagnosed benign tumor of the parotid gland.
  • CONCLUSIONS: Extracapsular dissection of benign parotid tumors is associated with a low rate of postoperative complications, a fact that is confirmed by the available literature.
  • We therefore recommend that use of this technique always be considered as a means of treating benign parotid tumors as conservatively, that is, as uninvasively, as possible.
  • [MeSH-major] Facial Nerve Injuries / epidemiology. Parotid Gland / surgery. Parotid Neoplasms / surgery. Postoperative Complications / epidemiology

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  • (PMID = 20112414.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Spalding DR, Isla AM, Thompson JN, Williamson RC: Pancreas-sparing distal duodenectomy for infrapapillary neoplasms. Ann R Coll Surg Engl; 2007 Mar;89(2):130-5
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  • [Title] Pancreas-sparing distal duodenectomy for infrapapillary neoplasms.
  • INTRODUCTION: For neoplasms that arise in the third and fourth parts of the duodenum (D(3), D(4)), a duodenectomy that preserves the pancreas can provide adequate tumour clearance while avoiding the additional dissection and risk of the common alternative, pancreatoduodenectomy.
  • PATIENTS AND METHODS: Pancreas-sparing distal duodenectomy (PSDD) was performed in 14 patients with infrapapillary duodenal neoplasms between 1991-2002, and the clinical outcome is reviewed.
  • There were 11 malignant neoplasms (adenocarcinoma 5, stromal tumour 4, recurrent seminoma 1, plasmacytoma 1), 2 benign neoplasms (villous adenoma, lipoma) and 1 patient with steroid-induced ulceration.
  • Median operation time was 240 min and median blood loss 1197 ml, being greater for malignant than benign lesions (1500 ml versus 700 ml).
  • At a median follow-up of 47 months, three patients had died of recurrent disease while the other 10 were alive and well with no upper gastrointestinal symptoms.
  • CONCLUSIONS: Provided there is a minimum 1-cm clearance at the papilla, PSDD is a useful alternative to formal pancreatoduodenectomy in patients with unusual neoplasms arising from the third and fourth parts of the duodenum.
  • Although a major undertaking in its own right, it avoids the extra time of a pancreatic resection and the extra risk of a pancreatic anastomosis.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Duodenal Neoplasms / surgery. Pancreas / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17346405.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1964558
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51. Della Volpe C, Salazard B, Casanova D, Vacheret H, Bartoli JF, Magalon G: Hibernoma of the antero-lateral thigh. Br J Plast Surg; 2005 Sep;58(6):859-61
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  • Hibernoma is a rare benign tumour of brown fat.
  • We report a case of a hibernoma on the thigh and present the diagnostic and therapeutic elements of this type of tumour, whose differential diagnosis of liposarcoma.
  • [MeSH-major] Lipoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Liposarcoma / diagnosis. Magnetic Resonance Imaging. Thigh. Tomography, X-Ray Computed

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  • (PMID = 15950954.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Hadar T, Shvero J, Yaniv E, Shvili I, Leabu M, Koren R: Human topoisomerase II-alpha is highly expressed in sinonasal-inverted papilloma, but not in inflammatory polyp. J Cell Mol Med; 2008 Sep-Oct;12(5A):1551-8
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  • Sinonasal-inverted papilloma is a benign tumour with a high rate of recurrence, but possible malignant transformation.
  • Topoisomerase II-alpha (topoII-alpha) and Ki67 are markers of cell proliferation in both normal and neoplastic tissues and its level o expression could be used as a predictive parameter.
  • [MeSH-major] Antigens, Neoplasm / metabolism. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Nose Neoplasms / enzymology. Nose Neoplasms / pathology. Papilloma, Inverted / enzymology. Papilloma, Inverted / pathology

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  • (PMID = 18544048.001).
  • [ISSN] 1582-1838
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC3918071
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53. Elliott DD, Fanning CV, Caraway NP: The utility of fine-needle aspiration in the diagnosis of gastrointestinal stromal tumors: a cytomorphologic and immunohistochemical analysis with emphasis on malignant tumors. Cancer; 2006 Feb 25;108(1):49-55
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  • [Title] The utility of fine-needle aspiration in the diagnosis of gastrointestinal stromal tumors: a cytomorphologic and immunohistochemical analysis with emphasis on malignant tumors.
  • BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the tubular gut and mesentery.
  • Fine-needle aspiration biopsy (FNAB) currently is a useful tool in the diagnosis of GIST because of various mutations of the KIT protooncogene that are recognized as characteristic of these tumors.
  • Therefore, in the current study, the authors have reported their experience with FNAB as a diagnostic tool in one of the largest series of malignant GISTs and have analyzed the cytomorphologic features of the tumors relative to their clinical behavior to determine which, if any, cytologic features are indicators of malignancy.
  • All tumors were reviewed for various cytomorphologic features.
  • For study purposes, the patients were divided into two groups: Group A included all patients with malignant tumors, defined as those with metastatic disease or recurrent disease after adequate surgery with or without chemotherapy; Group B included all other patients.
  • RESULTS: In total, 26 tumors from 23 patients (8 males and 15 females) with a mean age of 60.9 years were available for review.
  • There were 14 primary tumors, 7 metastases (to the liver), and 5 recurrences.
  • Twenty-one tumors were unequivocally malignant and were placed into Group A; the remaining 5 tumors were placed into Group B.
  • The tumors in both groups were characterized by spindled or epithelioid cells with minimal nuclear atypia or pleomorphism and a moderate amount of cytoplasm.
  • None of the cytologic features that were evaluated could distinguish reliably between benign tumors and malignant tumors, as expected.
  • However, on cytologic examination, all tumors that demonstrated mitoses (n = 7 tumors) and/or pretreatment necrosis (n = 3 tumors) were identified as malignant.
  • CONCLUSIONS: FNAB remains a reliable method for the diagnosis of GIST.
  • Immunohistochemical staining of cytologic material with CD117 has been reliable in establishing this diagnosis by FNAB, provided adequate tissue is procured.
  • In the current study, the presence of necrosis or mitoses in cytologic specimens was correlated with a diagnosis of malignant GIST.
  • [MeSH-major] Biopsy, Fine-Needle. Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Male. Middle Aged. Necrosis / pathology. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Proto-Oncogene Proteins c-kit / metabolism

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 16130141.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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54. Hundepool AC, Dumans AG, Hofer SO, Fokkens NJ, Rayat SS, van der Meij EH, Schepman KP: Rehabilitation after mandibular reconstruction with fibula free-flap: clinical outcome and quality of life assessment. Int J Oral Maxillofac Surg; 2008 Nov;37(11):1009-13
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  • Tumors (benign or malignant), osteoradionecrosis or osteomyelitis sometimes lead to large segmental resections of the mandible.
  • Only a small percentage of patients with segmental mandibular reconstructions with an OFFF received complete dental rehabilitation, mainly because of poor survival after treatment for malignant tumors of the oral cavity.
  • [MeSH-major] Dental Prosthesis, Implant-Supported. Mandibular Diseases / surgery. Mandibular Neoplasms / surgery. Mandibular Prosthesis. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 18657394.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Dental Implants
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55. Brant-Zawadzki G, Mathews MS, Duma CM, Kim B, Chen P, Heinemann S, Brant-Zawadzki M: Central neurocytoma: case report of an 81-year-old and histopathologic findings. Neuroradiol J; 2007 Feb 28;20(1):61-6
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  • Central Neurocytomas are rare and usually benign tumors found primarily in the lateral ventricles of the brain.
  • A review of published literature on central neurocytomas revealed that this tumor occurs most frequently in young adults with a median age between 25 and 30 years.
  • Gamma Knife radiosurgery was successful in decreasing the tumor volume by 20% at the four month follow-up, but the fact that the patient died of unrelated occurrences in the elderly cannot be ruled out.

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  • (PMID = 24299591.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Hafner C, Landthaler M, Mentzel T, Vogt T: FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. Br J Dermatol; 2010 Mar;162(3):508-12
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  • However, the genetic alterations involved in the pathogenesis of these benign tumours are unknown.

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  • (PMID = 19845664.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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57. Sak SD, Koseoglu RD, Demirag F, Akbulut H, Gungor A: Alveolar adenoma of the lung. Immunohistochemical and flow cytometric characteristics of two new cases and a review of the literature. APMIS; 2007 Dec;115(12):1443-9
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  • Alveolar adenoma is a rare and benign tumour of the lung that usually presents in asymptomatic patients as a coin lesion on chest radiography.
  • Immunohistochemical analysis may aid in the characterization of alveolar adenoma and discriminate this condition from other types of benign lesions of the lung.
  • An indolent clinical progression and absence of recurrence and metastasis after complete resection are the most important characteristics indicative of the benign nature of alveolar adenoma.
  • In this article we describe the immunohistochemical and flow cytometric features of this neoplasm in two male patients.
  • Both the tumours showed a diploid DNA pattern with a low proliferation index. p53 test was found to be negative, and post-operative follow-up examinations at 22 and 32 months proved uneventful.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Proliferation. Flow Cytometry. Humans. Immunohistochemistry. Lung Neoplasms / genetics. Lung Neoplasms / metabolism. Lung Neoplasms / pathology. Male. Middle Aged. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 18184418.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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58. Zhou WX, Zeng X, Liu TH, Wu SF: [Analysis of 13q14 chromosomal instability in soft tissue tumors by fluorescence in-situ hybridization]. Zhonghua Bing Li Xue Za Zhi; 2007 Sep;36(9):582-6
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  • [Title] [Analysis of 13q14 chromosomal instability in soft tissue tumors by fluorescence in-situ hybridization].
  • OBJECTIVE: To investigate the genetic status of 13q and its role in the oncogenesis and progress of soft tissue tumors.
  • METHODS: Forty-one soft tissue tumors, including 9 benign tumors, 9 tumors of malignant potential and 23 sarcomas, were studied by fluorescence in-situ hybridization (FISH) using dual color probes.
  • One case of malignant peripheral nerve sheath tumor showed amplification at all 3 loci.
  • CONCLUSIONS: A significant percentage of soft tissue tumors exhibited chromosomal instability, reflected by an increase of LOH at tumor-suppressing gene loci.
  • The incidence of 13q abnormality was different in various types of soft tissue tumors, indicating that alterations of Rb, RFP2, KCNRG and KLF5 tumor suppressing genes may play diverse roles in different types of soft tissue tumor.
  • [MeSH-major] Chromosomal Instability. Chromosomes, Human, Pair 13. Loss of Heterozygosity. Retroperitoneal Neoplasms / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Gastrointestinal Stromal Tumors / genetics. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Young Adult

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  • (PMID = 18070444.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Barwijuk AJ, Bonarek-Sztaba J: [Comparison of gas and gasless laparoscopy in the treatment of benign ovarian tumors]. Ginekol Pol; 2006 Jun;77(6):450-1, 454-7
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  • [Title] [Comparison of gas and gasless laparoscopy in the treatment of benign ovarian tumors].
  • OBJECTIVES: The aim of the study was to compare the outcomes of the gas and gasless laparoscopy in the treatment of benign ovarian tumors.
  • An ovarian tumor considered to be benign was the indication to operation.
  • Those assessments revealed that all tumors had been benign.
  • [MeSH-major] Laparoscopy / methods. Ovarian Neoplasms / surgery. Pneumoperitoneum, Artificial / methods

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  • (PMID = 16964696.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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60. Duek SD, Krausz MM, Hershko DD: Transanal endoscopic microsurgery for rectal cancer. Isr Med Assoc J; 2005 Jul;7(7):435-8
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  • METHODS: Local resection by TEM was performed in patients with benign tumors and early rectal cancer.
  • Radical surgery was offered to all patients with incomplete tumor excision by TEM.
  • RESULTS: Overall, 116 TEM operations for rectal tumors were carried out between 1995 and 2003, including 74 patients with rectal adenomas and 42 patients with rectal carcinomas.
  • In 25 patients, TEM successfully removed all T1 tumors with clear tumor margins.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Humans. Minimally Invasive Surgical Procedures. Neoplasm Recurrence, Local. Neoplasm Staging / methods. Patient Selection. Prospective Studies. Treatment Outcome

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  • (PMID = 16011058.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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61. Brodsky JR, Kim DY, Jiang Z: Cervical lipoblastoma: case report, review of literature, and genetic analysis. Head Neck; 2007 Nov;29(11):1055-60
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  • BACKGROUND: Lipoblastoma is a rare, benign tumor of infants and children, usually occurring in the extremities and trunk, with only a few cases reported in the neck.
  • Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed.
  • Histology and genetic analysis confirmed the diagnosis of lipoblastoma.
  • MRI can be helpful in identifying the lipomatous nature of the mass, but the findings can be inconsistent due to variable maturity of fat cells and the mesenchymal content of the tumor.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 17427967.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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62. Choi SW, Song SH: Intrapelvic lipoblastoma with massive spinal canal invasion. Childs Nerv Syst; 2007 May;23(5):581-5
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  • OBJECTS: The lipoblastoma is a rare benign pediatric neoplasm that derives from embryonic white fat cells.
  • However, this tumor with spinal invasion in children is extremely rare.
  • We report a case of a 3-year-old boy who had lipoblastoma with massive invasion into the lower lumbosacral spinal canal.
  • Histopathologic diagnosis confirmed the lipoblastoma.
  • CONCLUSION: Lipoblastoma is a rare benign neoplasm and lumbosacral invasion is unique.
  • [MeSH-major] Lipoma / pathology. Neoplasms, Adipose Tissue / pathology. Pelvic Neoplasms / pathology. Spinal Cord Neoplasms / secondary

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  • (PMID = 17143644.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Coloring Agents
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63. Loo WT, Tong JM, Cheung MN, Chow LW: A new predictive and prognostic marker (ATP bioluminescence and positron emission tomography) in vivo and in vitro for delivering adjuvant treatment plan to invasive breast tumor patients. Biomed Pharmacother; 2006 Jul;60(6):285-8
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  • [Title] A new predictive and prognostic marker (ATP bioluminescence and positron emission tomography) in vivo and in vitro for delivering adjuvant treatment plan to invasive breast tumor patients.
  • In this preliminary study, the cell proliferation rate of normal (N=45), benign (N=29) and invasive breast tumor tissue (N=70) has been quantified in vitro by ATP bioluminescence assay.
  • Next, individual prognostic factor (tumor grades, lymph node involvement, estrogen and progesterone receptor and HER-2 status) has been correlated with the level of metabolic rate (ATP).
  • The results showed that invasive tumor had the highest level of ATP bioluminescence compared with that of benign tumor (mean difference=1.97) and the normal breast tissue (mean difference=2.75).
  • These findings suggested that the measurement of ATP level may serve as a mean for the detection of cell proliferation and hence a surrogate marker for disease prognosis.
  • [MeSH-major] Adenosine Triphosphate / metabolism. Breast Neoplasms / diagnosis. Positron-Emission Tomography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Chemotherapy, Adjuvant. Female. Fibroadenoma / diagnosis. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Luminescent Measurements. Middle Aged. Prognosis. Receptor, ErbB-2 / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 16860527.001).
  • [ISSN] 0753-3322
  • [Journal-full-title] Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
  • [ISO-abbreviation] Biomed. Pharmacother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 8L70Q75FXE / Adenosine Triphosphate; EC 2.7.10.1 / Receptor, ErbB-2
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64. Xu AM, Zhang SH, Zheng JM, Zheng WQ, Wu MC: Pathological and molecular analysis of sporadic hepatic angiomyolipoma. Hum Pathol; 2006 Jun;37(6):735-41
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  • We sought to better define the morphological variations and immunohistochemical and molecular features of this unusual tumor.
  • Histologically, HAML is composed of a heterogeneous mixture of blood vessels, smooth muscle, and adipose cells.
  • Most of the tumor cells were positive for HMB-45 (100%) and SMA (100%).
  • There was a typical monoclonal pattern in 35 of the 40 tumors.
  • Hepatic AML is a benign neoplasm with varied morphology and monoclonal growth.
  • HMB-45 is the best marker available for diagnosis.
  • Neither LOH nor MSI appears to play an important role in the pathogenesis of this tumor.
  • [MeSH-major] Angiomyolipoma / genetics. Angiomyolipoma / pathology. Biomarkers, Tumor / analysis. Liver Neoplasms / genetics. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / analysis. Chromosomes, Human, X. Clone Cells. DNA, Neoplasm / analysis. Female. Hepatectomy. Humans. Immunohistochemistry. Lasers. Male. Melanoma-Specific Antigens. Microdissection. Middle Aged. Muscle, Smooth / cytology. Muscle, Smooth / metabolism. Neoplasm Proteins / analysis. Prospective Studies. Receptors, Androgen / metabolism. Sex Chromosome Aberrations. Tumor Burden

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  • (PMID = 16733215.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Receptors, Androgen
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65. Albisinni U, Rimondi E, Malaguti MC, Ciminari R, Bianchi G, Mercuri M: Radiofrequency thermal ablation of non spinal osteoid osteoma: remarks on method. Radiol Med; 2005 May-Jun;109(5-6):555-62
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  • [Title] Radiofrequency thermal ablation of non spinal osteoid osteoma: remarks on method.
  • Osteoid osteoma is a small benign tumor, with a ''nidus'' that rarely exceeds 15 mm in diameter.
  • For that reason radiofrequency thermal ablation has become the treatment of choice for non-spinal osteoid osteoma at Rizzoli Orthopaedic Institute.

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  • (PMID = 15973230.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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66. Inai K, Shimizu Y, Kawai K, Tokunaga M, Soda M, Mabuchi K, Land CE, Tokuoka S: A pathology study of malignant and benign ovarian tumors among atomic-bomb survivors--case series report. J Radiat Res; 2006 Mar;47(1):49-59
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  • [Title] A pathology study of malignant and benign ovarian tumors among atomic-bomb survivors--case series report.
  • The present article describes the series of incident primary ovarian tumors in the Life Span Study (LSS) cohort of the Radiation Effects Research Foundation, with particular emphasis on case ascertainment and characterization of histological features of the tumors.
  • We identified 723 ovarian tumors (260 malignant, 463 benign) in 648 individuals of about 70,000 female LSS subjects; 71 cases had more than one ovarian tumor.
  • We histologically confirmed 601 tumors (182 malignant, 419 benign tumors).
  • The most frequent histological type was common epithelial tumor (90.7% for malignant and 59.7% for benign tumors).
  • The distributions of ovarian tumors by histological type were similar to those from other studies.
  • Among malignancies, the frequency of common epithelial types relative to other tumor types increased with radiation dose (p = 0.02).
  • Among benign tumors, the relative frequency of sex-cord stromal tumors increased with radiation dose (p = 0.04).
  • Within tumor types, there was no consistent pattern of survival by radiation dose.
  • Variations in histological types of ovarian tumors in response to radiation dose, suggested by the case series data need to be followed up by population-based incidence analysis.
  • [MeSH-major] Neoplasms, Radiation-Induced / mortality. Neoplasms, Radiation-Induced / pathology. Nuclear Warfare / statistics & numerical data. Ovarian Neoplasms / mortality. Ovarian Neoplasms / pathology. Risk Assessment / methods. Survivors / statistics & numerical data

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  • (PMID = 16571918.001).
  • [ISSN] 0449-3060
  • [Journal-full-title] Journal of radiation research
  • [ISO-abbreviation] J. Radiat. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CP / N01-CP-31012; United States / NCI NIH HHS / CP / N01-CP-71015
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Japan
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67. Puylaert JB, Coerkamp EG: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 Jul 21;151(29):1653; author reply 1653
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  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblass; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1049-54 [17552411.001]
  • (PMID = 17727189.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Netherlands
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68. Chiang ER, Chen TH: Multiple glomus tumors in gastrocnemius muscle: a case report. Arch Orthop Trauma Surg; 2008 Jan;128(1):29-31
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  • [Title] Multiple glomus tumors in gastrocnemius muscle: a case report.
  • Glomus tumors are rare benign tumors that account 1-5% of soft tissue tumors of the hand.
  • We describe an unusual case of recurrent glomus tumor located in lower leg.
  • The final diagnosis was established by pathologic examination of the surgical resection specimen.
  • [MeSH-major] Glomus Tumor / diagnosis. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17624538.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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69. Hakan T, Vardar Aker F: Chondromyxoid fibroma of frontal bone: a case report and review of the literature. Turk Neurosurg; 2008 Jul;18(3):249-53
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  • Chondromyxoid fibroma is an unusual benign tumor of cartilaginous tissues that may be confused with other some malign tumors.
  • The patient underwent tumor excision with craniectomy, then acrylic cranioplasty.
  • The histopathological diagnosis was chondromyxoid fibroma.
  • In conclusion, chondromyxoid fibroma is a benign primary bone tumor that is located extremely rarely in the frontal bone.
  • Accurate initial diagnosis of such tumors are important for appropriate treatment.
  • En block surgical resection of the tumor is the cornerstone of treatment.
  • [MeSH-major] Chondroma / pathology. Fibroma / pathology. Frontal Bone / pathology. Skull Neoplasms / pathology

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  • (PMID = 18814113.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 22
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70. Jones AC, Prihoda TJ, Kacher JE, Odingo NA, Freedman PD: Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Nov;102(5):639-50
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  • Osteoblastoma is a benign neoplasm of bone characterized by a proliferation of osteoblasts forming bone trabeculae set in a vascularized fibrous connective tissue stroma.
  • We report 24 examples of this neoplasm arising in the maxilla and mandible and compare the clinical and radiographic characteristics of this neoplasm to 53 previously reported examples of osteoblastoma and osteoid osteoma in the jaws.
  • In addition, significantly fewer patients reported pain, tenderness, and discomfort associated with their neoplasms than in previously reported cases.
  • We also provide a rationale for use of the term "osteoblastoma" for any benign osteoblastic neoplasm arising in the jaws.
  • [MeSH-major] Jaw Neoplasms / pathology. Osteoblastoma / pathology. Osteoma, Osteoid / pathology

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  • (PMID = 17052641.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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71. Völk M, Strotzer M: [Diagnostic imaging of splenic disease]. Radiologe; 2006 Mar;46(3):229-43; quiz 244
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  • [Title] [Diagnostic imaging of splenic disease].
  • Hemangioma represents the most common primary benign tumor, and lymphoma the most common primary malignant tumor of the spleen.
  • Diagnostic imaging does not a allow safe differentiation between Hodgkin's and non-Hodgkin's lymphoma.
  • Additional clarification using CT or MRT should be reserved for cases with a strong suspicion of clinically relevant primary or secondary splenic disease.
  • [MeSH-major] Diagnostic Imaging / methods. Image Enhancement / methods. Spleen / diagnostic imaging. Spleen / pathology. Splenic Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Radiography

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  • (PMID = 16435091.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
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72. Venturi A, Piscaglia F, Vidili G, Flori S, Righini R, Golfieri R, Bolondi L: Diagnosis and management of hepatic focal nodular hyperplasia. J Ultrasound; 2007 Sep;10(3):116-27
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  • [Title] Diagnosis and management of hepatic focal nodular hyperplasia.
  • Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma.
  • Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH.
  • Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients.

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  • (PMID = 23396642.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3478711
  • [Keywords] NOTNLM ; Contrast-enhanced ultrasonography / Diagnosis / Focal nodular hyperplasia / Management / Ultrasonology
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73. Brønden LB, Eriksen T, Kristensen AT: Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2009;51:54
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  • [Title] Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • Neoplasms originating in the head and neck region are a heterogeneous group.
  • HNC often has an unfavourable prognosis and the proximity of the tissue structures renders extirpation of tumours with sufficient margins almost incompatible with preservation of functionality.
  • Also the proportions of benign and malignant neoplasms of different locations in dogs were compared using Fisher's exact test.
  • RESULTS: A total of 1768 cases of neoplasias (679 malignant, 826 benign, 263 unknown) were submitted.
  • Of all neoplasias HNC accounted for 7.2% (n = 128).
  • Of these, 64 (50%) were malignant and 44 (34%) benign.
  • The most common types of malignant neoplasia were SCC (18; 28% of malignant), OMM (13; 20% of malignant), soft tissue sarcoma (11; 17% of malignant) and adenocarcinoma (5; 11% of malignant).
  • The most common types of benign neoplasms were adenoma (7; 16% of benign), polyps (6; 14% of benign) and fibroma (5; 11% of benign).
  • CONCLUSIONS: In the current study, the proportion of neoplasia in the head and neck region in dogs in Denmark was similar to other canine studies and significantly more common than in humans with a large proportion of malignancies.
  • [MeSH-major] Dog Diseases / epidemiology. Head and Neck Neoplasms / veterinary. Melanoma / veterinary. Mouth Neoplasms / veterinary. Registries
  • [MeSH-minor] Animals. Denmark / epidemiology. Disease Models, Animal. Dogs. Incidence

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  • (PMID = 20021647.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803174
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74. Schemmer P, Decker F, Dei-Anane G, Henschel V, Buhl K, Herfarth C, Riedl S: The vital threat of an upper gastrointestinal bleeding: Risk factor analysis of 121 consecutive patients. World J Gastroenterol; 2006 Jun 14;12(22):3597-601
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  • METHODS: From 1998 to 2001, 121 patients with the diagnosis of UGI bleeding were treated in our hospital.
  • UGI bleeding occurred due to duodenal ulcer (n = 36; 30%), gastric ulcer (n = 35; 29%), esophageal varicosis (n = 12; 10%), Mallory-Weiss syndrome (n = 8; 7%), erosive lesions of the mucosa (n = 20; 17%), cancer (n = 5; 4%), coagulopathy (n = 4; 3%), lymphoma (n = 2; 2%), benign tumor (n = 2; 2%) and unknown reason (n = 1; 1%).
  • Thereafter, liver cirrhosis, the location of a bleeding ulcer (bulbus back wall) and patients' gender (male) were of prognostic importance for the clinical outcome (mortality) of patients with a bleeding ulcer.

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  • (PMID = 16773718.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087577
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75. Chatelain D, Mokrani N, Fléjou JF: [Anal and anal margin tumors]. Ann Pathol; 2007 Dec;27(6):459-75
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  • [Title] [Anal and anal margin tumors].
  • Tumors of the anal canal and anal margin are rare.
  • Benign tumors mainly consist of condylomas, cloacogenic polyps and fibro-epithelial polyps.
  • The other malignant tumors are very rare.
  • [MeSH-major] Anus Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Endocrine Gland Neoplasms / epidemiology. Endocrine Gland Neoplasms / pathology. France / epidemiology. Humans. Incidence. Leiomyosarcoma / pathology. Lymphoma / pathology. Melanoma / epidemiology. Melanoma / pathology. Papilloma / pathology. Sarcoma, Kaposi / pathology

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  • (PMID = 18554556.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 110
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76. Menéndez-Skertchly AL, Ortiz-Hidalgo C, Quijano-Orvańanos F, Cervantes-Monteil F, Chousleb-Kalach A, Padilla-Longoria R, Godoy-Valdés S, Vidal-González P, Herrera MF: [Endocrine tumors of the pancreas: experience in the ABC Medical Center]. Rev Gastroenterol Mex; 2006 Jul-Sep;71(3):296-301
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  • [Title] [Endocrine tumors of the pancreas: experience in the ABC Medical Center].
  • [Transliterated title] Tumores endocrinos del páncreas: experiencia en el Centro Médico ABC.
  • OBJECTIVES: To analyze presentation, diagnosis and treatment of islet cell tumors at the ABC Medical Center.
  • MATERIALS AND METHODS: Medical records of the 7 patients with endocrine tumors diagnosed between 1995 and 2005 were reviewed and analyzed, with emphasis to clinical, biochemical and radiological characteristics, surgical treatment and outcome.
  • RESULTS: There were 3 insulinomas, 1 gastrinoma, 1 VIPoma, and 2 non-functioning tumors.
  • The tumor was localized before surgery in 2 cases.
  • In all patients intraoperative ultrasound confirmed the tumor and enucleation was performed in all three.
  • The patient with gastrinoma was diagnosed by endoscopy in the presence of metastatic disease, therefore no surgical treatment was performed.
  • A tumor in the pancreatic head was found and it was resected by pancreaticoduodenectomy.
  • Both non functioning tumors were found by imaging studies, one benign tumor was treated by central pancreatectomy and the other was malignant and underwent distal en-block pancreatectomy.
  • Immunohistochemistry was positive for VIP in the benign lesion.
  • Two of the 3 malignant tumors have died and one is alive with recurrent disease.
  • CONCLUSIONS: Distribution of islet cell tumors in our series followed the usual patterns.
  • Imaging studies localized the tumor in 7 of the 8 patients.
  • Surgical resection cured all benign tumors.
  • [MeSH-major] Pancreatic Neoplasms

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  • (PMID = 17140051.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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77. Ilvan S, Ramazanoglu R, Ulker Akyildiz E, Calay Z, Bese T, Oruc N: The accuracy of frozen section (intraoperative consultation) in the diagnosis of ovarian masses. Gynecol Oncol; 2005 May;97(2):395-9
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  • [Title] The accuracy of frozen section (intraoperative consultation) in the diagnosis of ovarian masses.
  • OBJECTIVE: Frozen section is an important and helpful adjunct in the intraoperative diagnosis of ovarian tumors.
  • This retrospective study was undertaken to determine the accuracy of frozen section diagnosis of ovarian masses and the reasons of discordance.
  • RESULTS.: The final paraffin section diagnoses of these 617 cases were a nonneoplastic lesion in 18.3% of the cases, benign tumor in 56.1%, borderline tumor in 6.2%, and malignant tumor in 19.4%.
  • The majority of the cases of disagreement were mucinous and borderline tumors.
  • The sensitivity for benign, borderline, and malignant tumors were 100%, 87%, and 87%, respectively.
  • The specificity for benign tumors was 97%; for borderline tumors 98%; and for malignant tumors 100%.
  • CONCLUSION: Our data confirm that frozen section diagnosis is a reliable method for the surgical management of patients with an ovarian mass.
  • However, diagnostic problems can occur in mucinous and borderline tumors during frozen section examination.
  • [MeSH-major] Ovarian Neoplasms / pathology

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  • (PMID = 15863135.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Nishimura K, Satoh T, Maesawa C, Ishijima K, Sato H: Giant cell tumor of the larynx: a case report and review of the literature. Am J Otolaryngol; 2007 Nov-Dec;28(6):436-40
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  • [Title] Giant cell tumor of the larynx: a case report and review of the literature.
  • Giant cell tumors are benign tumors commonly found in the long bones.
  • Rarely, they may occur in the larynx, and patients with such tumors may present with hoarseness and anterior neck swelling.
  • Since Wessely reported the first case of laryngeal giant cell tumor in 1940, 30 cases have been identified.
  • Herein, we present a case of a 31-year-old man with giant cell tumor of the larynx successfully treated via the hemilaryngectomy approach.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Giant Cell Tumors / therapy. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / therapy

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  • (PMID = 17980781.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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79. Chung SH, Park YS, Jo YJ, Kim SH, Jun DW, Son BK, Jung JY, Baek DH, Kim DH, Jung YY, Lee WM: Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults. World J Gastroenterol; 2009 Nov 28;15(44):5620-3
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  • Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults.
  • Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple septa in the spleen and a 10 cm lobulated cystic mass in the paraaortic area.
  • [MeSH-major] Lymphangioma / diagnosis. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Space / pathology. Spleen / pathology

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  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
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80. Bianchi LC, Marchetti M, Brait L, Bergantin A, Milanesi I, Broggi G, Fariselli L: Paragangliomas of head and neck: a treatment option with CyberKnife radiosurgery. Neurol Sci; 2009 Dec;30(6):479-85
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  • Paragangliomas are highly vascular and predominantly benign neoplasms that have traditionally been treated by surgery, embolization and/or external beam radiotherapy (EBRT).
  • The aim of this study is to evaluate the short-term local tumor control and safety of CyberKnife radiosurgery for these lesions.
  • [MeSH-major] Carotid Body Tumor / surgery. Glomus Jugulare Tumor / surgery. Head and Neck Neoplasms / surgery. Radiosurgery / methods

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  • (PMID = 19774334.001).
  • [ISSN] 1590-3478
  • [Journal-full-title] Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
  • [ISO-abbreviation] Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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81. Liu K, Tripp S, Layfield LJ: Heterotopic ossification: review of histologic findings and tissue distribution in a 10-year experience. Pathol Res Pract; 2007;203(9):633-40
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  • Heterotopic ossification (HO) within tissues involved by a pathologic process is a well-recognized phenomenon.
  • Less frequently, carcinomas and some benign neoplasms will undergo heterotopic ossification.
  • We performed a retrospective review of our experience with HO over a 10-year period to determine the frequency and tissue site distribution of heterotopic ossification.
  • A computerized review of surgical pathology records of approximately 126,000 reports revealed 85 cases in which heterotopic ossification, ectopic bone or metaplastic bone was specifically mentioned in the surgical pathology diagnosis.
  • Twenty-two cases were neoplasms of non-osseous tissues, and 63 cases were non-neoplastic lesions.
  • HO is a relatively infrequent finding and is more commonly seen in degenerative and reparative conditions than in neoplasms.
  • [MeSH-major] Arthritis / pathology. Atherosclerosis / pathology. Bone Morphogenetic Proteins / analysis. Neoplasms, Bone Tissue / pathology. Ossification, Heterotopic / pathology

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  • (PMID = 17728073.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / BMP4 protein, human; 0 / BMP6 protein, human; 0 / Bone Morphogenetic Protein 4; 0 / Bone Morphogenetic Protein 6; 0 / Bone Morphogenetic Proteins; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.19 / BMP1 protein, human; EC 3.4.24.19 / Bone Morphogenetic Protein 1
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82. Shabbir M, Kirby RS: Fact or fiction: what do the benign prostatic hyperplasia data tell us? Curr Urol Rep; 2005 Jul;6(4):243-50
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  • [Title] Fact or fiction: what do the benign prostatic hyperplasia data tell us?
  • Benign prostatic hyperplasia (BPH) is the most common benign neoplasm in men.
  • We now have a number of medical therapies and minimally invasive treatment options available that can effectively manage lower urinary tract symptoms secondary to benign prostatic obstruction.
  • [MeSH-minor] Algorithms. Animals. Catheter Ablation. Disease Progression. Humans. Laser Coagulation. Male. Prostate / surgery. Quality of Life. Rats. Stents. Transurethral Resection of Prostate. Urinary Retention / etiology. Urodynamics


83. Algin C, Hacioğlu A, Aydin T, Ihtiyar E: Esophagectomy in esophageal lipoma: report of a case. Turk J Gastroenterol; 2006 Jun;17(2):110-2
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  • [Title] Esophagectomy in esophageal lipoma: report of a case.
  • Lipoma is an uncommon benign tumor of the alimentary tract and its overall incidence is 4.1%, but that of the esophagus is extremely rare, with an incidence of only 0.4%.
  • Computed tomography and abdominal ultrasonography were performed because of endoscopic suspicion of submucosal tumor, and the mass was confirmed to be a lipoma in the wall of the esophagus.
  • Surgical excision by enucleation of the tumor is the preferred treatment of esophageal lipoma, but opening of the esophageal mucosa during this procedure is a rare cause for esophageal resection.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagectomy / methods. Lipoma / surgery

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  • (PMID = 16830292.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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84. Schulz R, Horstmann S, Jokeit H, Woermann FG, Ebner A: Epilepsy surgery in professional musicians: subjective and objective reports of three cases. Epilepsy Behav; 2005 Nov;7(3):552-8
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  • We describe a small series of three professional musicians who had right (two patients) and left (one patient) temporal lobe epilepsy surgery with the histological diagnoses of hippocampal sclerosis (two patients) and benign tumor (one patient, xanthoastrocytoma).

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  • (PMID = 16143569.001).
  • [ISSN] 1525-5050
  • [Journal-full-title] Epilepsy & behavior : E&B
  • [ISO-abbreviation] Epilepsy Behav
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives; GWH6IJ239E / Amobarbital
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85. Orhan KS, Karaaltın MV, Demirel T, Polat B, Başaran B: Adenolipoma of the nose: a case report. Kulak Burun Bogaz Ihtis Derg; 2010 Sep-Oct;20(5):264-6
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  • Adenolipoma is a rare benign neoplasm composed of both mature adipose tissue and glandular elements.
  • [MeSH-major] Adenoma / surgery. Lipoma / surgery. Nose Neoplasms / surgery

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  • (PMID = 20815806.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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86. Curien R, Moizan H, Gerard E: Gingival metastasis of a bronchogenic adenocarcinoma: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Dec;104(6):e25-8
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  • [Title] Gingival metastasis of a bronchogenic adenocarcinoma: report of a case.
  • We report the case of a 64-year-old patient suffering from a multiple metastatic bronchial adenocarcinoma, referred to our department for a gingival tumefaction.
  • The diagnostic assumptions considered were those of a pyogenic granuloma, of a primary gingival carcinoma, or of a metastasis of the bronchial tumor.
  • An excisional biopsy was carried out and the histopathologic examination confirmed the latter diagnosis.
  • The main clinical diagnostic difficulty is the distinction between benign lesion and malignant lesion, and between primary lesion and metastasis.
  • Even if gingival metastases are rare, their semiological value incites the histopathologic examination of any presumedly benign tumor of the gingiva.
  • [MeSH-major] Carcinoma, Bronchogenic / secondary. Gingival Neoplasms / secondary. Lung Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 17942337.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Ignaszak-Szczepaniak M, Horst-Sikorska W, Sawicka J, Kaczmarek M, Slomski R: The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients. Oncol Rep; 2006 Jul;16(1):65-71
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  • We have analyzed the 72Pro polymorphic variant in patients with adrenocortical tumors to evaluate whether 72G--> C substitution at codon 72 of TP53 gene may be associated with increased risk for malignancy in adrenal cortex in comparison to the control group.
  • DNA extracted from peripheral leucocytes of 46 Polish patients with adrenocortical tumors (17 malignant and 29 benign) and 50 controls was examined by PCR-HD method followed by direct sequencing.
  • The genotype Arg/Arg, Arg/Pro and Pro/Pro distribution was respectively 53%/35%/12% for cancers, 72%/28%/0% for benign tumors and 76%/24%/0% for controls.
  • High frequency of 72Pro allele in patients with carcinoma (29%) in comparison to the benign tumors (14%) and controls (12%) was statistically analyzed.
  • [MeSH-major] Adrenal Cortex Neoplasms / genetics. Genetic Predisposition to Disease. Polymorphism, Genetic. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 16786124.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Codon; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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88. Russo A, Zaottini A: [Diagnosis of synovial sarcoma of the knee accidentally revealed by trauma. Role of ultrasound. Differential diagnosis by scar-hematoma]. Ann Ital Chir; 2009 Mar-Apr;80(2):151-7
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  • [Title] [Diagnosis of synovial sarcoma of the knee accidentally revealed by trauma. Role of ultrasound. Differential diagnosis by scar-hematoma].
  • [Transliterated title] Diagnosi di sarcoma sinoviale del ginocchio fortuitamente favorita da evento traumatico. Il contributo dell'ecografia in urgenza al sospetto clinico e la diagnosi differenziale con l'ematoma in fase di cicatrizzazione.
  • Generally arising in the contest of joint or from immediately surrounding anatomical sites, first of all affecting inferior limbs (2/3), a sarcoma of the knee, elective anatomical site, is described, accidentally diagnosed after traumatic event.
  • Exhibiting a very poor 5 year survey, (55%), related to dimension, distal or proximal arising, necrosis rate and grading, it's the most fequently soft tissue malignancy misdiagnosed with benign neoplasms, such as Baker cyst or villonodular pigmented synovitis, considering its deceiving macroscopic and chronological features; the differential diagnosis seems to be very hard, relying on histhological biopsy.
  • [MeSH-major] Cicatrix, Hypertrophic / ultrasonography. Hematoma / ultrasonography. Knee Injuries / ultrasonography. Knee Joint / ultrasonography. Sarcoma, Synovial / ultrasonography. Soft Tissue Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Incidental Findings. Male. Middle Aged. Prognosis. Treatment Outcome

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  • (PMID = 19681299.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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89. Bartuma H, Domanski HA, Von Steyern FV, Kullendorff CM, Mandahl N, Mertens F: Cytogenetic and molecular cytogenetic findings in lipoblastoma. Cancer Genet Cytogenet; 2008 May;183(1):60-3
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  • Lipoblastoma is a rare benign tumor that arises from embryonic adipose tissue and usually occurs in young children.
  • All seven tumors with clonal aberrations harbored breakpoints in 8q11 approximately q13, in agreement with literature data.

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  • (PMID = 18474299.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human
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90. Tatli S, Lipton MJ: CT for intracardiac thrombi and tumors. Int J Cardiovasc Imaging; 2005 Feb;21(1):115-31
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  • [Title] CT for intracardiac thrombi and tumors.
  • Although cardiac tumors are rare, they nevertheless represent an important subgroup, the diagnosis of which is challenging for the primary care physician.
  • Symptoms are not characteristic and serious complications including stroke, myocardial infarction and even sudden death from arrhythmia may be the first signs of tumor.
  • The most common primary cardiac neoplasm is the benign myxoma and the most frequent primary malignant lesion is sarcoma.
  • Echocardiography until the past decade was the only consistently reliable and available non-invasive diagnostic tool.
  • New non-invasive CT and MRI exams are changing the diagnostic approach.
  • Echocardiography and angiocardiography with or without coronary arteriography remain routine methods for evaluating cardiac neoplasms.
  • This chapter reviews the wide spectrum of intracardiac thrombi and tumors including their incidence and imaging characteristics with particular reference to the CT findings and differential diagnosis.
  • [MeSH-major] Coronary Thrombosis / diagnostic imaging. Heart Neoplasms / diagnostic imaging. Myxoma / diagnostic imaging. Sarcoma / diagnostic imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 15915945.001).
  • [ISSN] 1569-5794
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 76
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91. Cho KJ, Ro JY, Choi J, Choi SH, Nam SY, Kim SY: Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases. Eur Arch Otorhinolaryngol; 2008 Jul;265 Suppl 1:S47-56
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  • [Title] Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases.
  • Non-lymphoid mesenchymal neoplasms of salivary gland origin are rare, accounting for 1.9-5% of major salivary gland tumors.
  • We describe the clinico-pathologic features of 18 cases of mesenchymal neoplasms of the major salivary glands experienced at Asan Medical Center, Seoul, Korea, from 1998 to 2004.
  • Mesenchymal neoplasms accounted for 3.4% of the total of 524 major salivary gland tumors.
  • The parotid gland was the preponderant site (15 cases).
  • Thirteen tumors were benign, constituting 3.5% of the total of 371 benign neoplasms.
  • Schwannomas were the most common benign tumors (six cases), followed by lipomas (three cases), plexiform neurofibroma, hemangioma, desmoid tumor, and solitary fibrous tumor (one each).
  • The malignant tumors consisted of one dermatofibrosarcoma protuberans, synovial sarcoma, leiomyosarcoma, pleomorphic liposarcoma and desmoplastic small round cell tumor each.
  • Genetic analysis for fusion transcripts was conclusive in the diagnosis of desmoplastic small round cell tumor, which is extremely rare at this location.
  • Pre-operative imaging study and fine needle aspiration cytology had limitations in prediction of the mesenchymal nature of the tumors, due to either low index of suspicion, similarities to mixed tumors, or specimen inadequacy.
  • Awareness of the development of various mesenchymal tumors in the major salivary glands could increase the accuracy of preoperative and postoperative diagnosis, and therapeutic efficacy.
  • [MeSH-major] Neoplasms, Connective and Soft Tissue / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Infant. Lipoma / diagnosis. Lipoma / pathology. Male. Middle Aged. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Solitary Fibrous Tumors / diagnosis. Solitary Fibrous Tumors / pathology

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  • (PMID = 17934743.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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92. Katergiannakis V, Lagoudianakis EE, Markogiannakis H, Manouras A: Huge epidermoid cyst of the spermatic cord in an adult patient. Int J Urol; 2006 Jan;13(1):95-7
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  • Tumors arising in the spermatic cord are uncommon and form a heterogeneous group of neoplasms.
  • A variety of both benign and malignant lesions have been demonstrated.
  • Benign tumors represent 80% of the total, but unfortunately clinical and sonographic features are not specific and they cannot safely differentiate a teratomatous or a malignant neoplasm from benign tumors.
  • We report a case of a huge epidermoid cyst of the spermatic cord in an adult patient confirmed after local excision.
  • The etiology, differential diagnosis, and management alternatives are discussed.
  • [MeSH-major] Epidermal Cyst / diagnosis. Genital Neoplasms, Male / diagnosis. Spermatic Cord
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Severity of Illness Index. Urogenital Surgical Procedures / methods

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  • (PMID = 16448444.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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93. Bozza F, Vigili MG, Ruscito P, Marzetti A, Marzetti F: Surgical management of parapharyngeal space tumours: results of 10-year follow-up. Acta Otorhinolaryngol Ital; 2009 Feb;29(1):10-5
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  • [Title] Surgical management of parapharyngeal space tumours: results of 10-year follow-up.
  • Although primary tumours of the parapharyngeal space are rare and account for only 0.5% of head and neck neoplasms, they represent a formidable challenge to the surgeon both in the assessment of the preoperative condition and the appropriate surgical approach.
  • This study is a retrospective review of the clinical records of 12 patients (8 male, 4 female, mean age 49 years), treated for parapharyngeal space tumours by the same surgical team from 1992 to 1998 and observed at follow-up for at least 10 years.
  • Of these, 8 (66.6%) were benign and 4 (33.4%) malignant.
  • The positive predictive value of our fine-needle aspiration biopsy was 75% for benign tumours (3/4) and 100% (4/4) for malignant tumours.
  • Eleven patients (91.4%) were still disease free after 10-year follow-up.
  • These 12 parapharyngeal space tumours were treated with use of one of the various surgical approaches described in relation to the histopathological diagnosis (benign or malignant), to the side (prestyloid or poststyloid) and to the size (+/-4 cm) of the neoplasia and, moreover, were observed at long-term follow-up.
  • Results of personal experience in the treatment of the tumours of the parapharyngeal space confirm the necessity to follow a careful preoperative diagnostic outline that must be taken advantage of the study for imaging (computed tomography, magnetic resonance imaging) and of cytology, in order to plan surgical treatment with a safe approach and that reduces complications, aesthetic-functional damages and risk of recurrence.
  • [MeSH-major] Head and Neck Neoplasms / surgery

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  • (PMID = 19609376.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2689563
  • [Keywords] NOTNLM ; Mandibulotomy / Parapharyngeal space / Parapharyngeal tumour / Parotid / Pleomorphic adenoma / Surgical approach
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94. Yu L, Moore AB, Dixon D: Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma. Semin Reprod Med; 2010 May;28(3):250-9
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  • Uterine leiomyomas (fibroids, myomas) are benign tumors that develop from smooth muscle cells.
  • Although the most common gynecologic tumor in premenopausal women, there is still little known of the etiology, the genetics and basic/molecular biology, or the influence of the environment on the development and growth of these tumors.
  • [MeSH-major] Hormones / metabolism. Leiomyoma / metabolism. Receptor Protein-Tyrosine Kinases / metabolism. Uterine Neoplasms / metabolism

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  • [Copyright] Published in 2010 by Thieme Medical Publishers.
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  • (PMID = 20414848.001).
  • [ISSN] 1526-4564
  • [Journal-full-title] Seminars in reproductive medicine
  • [ISO-abbreviation] Semin. Reprod. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogens; 0 / Hormones; 4G7DS2Q64Y / Progesterone; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
  • [Number-of-references] 49
  • [Other-IDs] NLM/ NIHMS322987; NLM/ PMC3183573
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95. Kaur H, Bagga R, Saha SC, Gainder S, Srinivasan R, Adhya AK, Dhaliwal LK: Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. Int J Clin Oncol; 2009 Feb;14(1):78-81
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  • [Title] Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites.
  • Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade.
  • Being solid tumors, they may be associated with ascites and pleural effusion (Meigs' syndrome), which resolve after surgical removal of the tumor.
  • Tumor markers for GCT are still investigational (inhibin) and of not much use in making a preoperative diagnosis, unlike in the case of germ cell tumors.
  • However, lymph node sampling is advocated for complete staging of these tumors, as a significant number of recurrences are reported in the retroperitoneum, as well as in incompletely staged patients.
  • In the present patient, because of the association of Meigs' syndrome, a preoperative diagnosis of benign tumors such as fibroma/thecoma was also considered.
  • We report this rare tumor with an aim of reviewing the diagnosis and management from the reported literature.
  • [MeSH-major] Ascites / etiology. Granulosa Cell Tumor / pathology. Meigs Syndrome / pathology. Ovarian Neoplasms / pathology. Pleural Effusion, Malignant / etiology

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  • (PMID = 19225930.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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96. Morris JS, Nixon C, King OJ, Morgan IM, Philbey AW: Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ERalpha and p53. Vet J; 2009 Mar;179(3):422-9
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  • [Title] Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ERalpha and p53.
  • In this study, 132 canine mammary tumours (46 benign, 86 carcinomas) were examined immunohistochemically for expression of TopBP1, oestrogen receptor alpha (ERalpha), Ki67 and p53.
  • The number of samples with high levels of staining increased in different categories from benign mixed tumour to adenoma to carcinoma.
  • Benign mixed tumours, however, had more cytoplasmic staining than adenomas.
  • Expression of p53 and the proliferation marker Ki67 increased from benign mixed tumour to adenoma to carcinoma, but the differences between benign and malignant tumours were more distinct than for TopBP1 expression.
  • ERalpha expression decreased from malignant to benign tumours, although over half of the benign mixed tumours were negative.
  • TopBP1 was expressed in canine mammary tumours at higher levels than has been reported previously for cats, although the shift in cellular localisation with malignancy was similar.
  • [MeSH-major] Dog Diseases / metabolism. Gene Expression Regulation, Neoplastic / physiology. Ki-67 Antigen / metabolism. Mammary Neoplasms, Animal / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18314357.001).
  • [ISSN] 1532-2971
  • [Journal-full-title] Veterinary journal (London, England : 1997)
  • [ISO-abbreviation] Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BRCA1 Protein; 0 / Carrier Proteins; 0 / Estrogen Receptor alpha; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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97. Holmes GL, Stafstrom CE, Tuberous Sclerosis Study Group: Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia; 2007 Apr;48(4):617-30
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  • Tuberous sclerosis complex (TSC) is a congenital syndrome characterized by the widespread development of benign tumors in multiple organs, caused by mutations in one of the tumor suppressor genes, TSC1 or TSC2.
  • The disorder affects approximately 1 in 6000 individuals.
  • While the molecular basis of TSC is well established, far less is known about the mechanisms of epilepsy in this disorder.
  • [MeSH-major] Epilepsy / genetics. Epilepsy / physiopathology. Genes, Tumor Suppressor / physiology. Tuberous Sclerosis / genetics. Tuberous Sclerosis / pathology
  • [MeSH-minor] Animals. Animals, Genetically Modified / genetics. Anticonvulsants / therapeutic use. Clinical Protocols. Consensus. Disease Models, Animal. Drug Resistance. Genetic Predisposition to Disease / genetics. Humans. Mice. Mice, Knockout. Mutation / genetics. Phenotype. Rats. Research Design / trends

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  • [CommentIn] Epilepsia. 2007 Aug;48(8):1629-30; author reply 1632-4 [17692051.001]
  • [CommentIn] Epilepsia. 2007 Aug;48(8):1632; author reply 1632-4 [17692054.001]
  • [CommentIn] Epilepsia. 2007 Aug;48(8):1630-1; author reply 1632-4 [17692052.001]
  • (PMID = 17386056.001).
  • [ISSN] 0013-9580
  • [Journal-full-title] Epilepsia
  • [ISO-abbreviation] Epilepsia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants
  • [Number-of-references] 131
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98. Donati M, Gandolfo L, Privitera A, Brancato G, Cardi F, Donati A: Superficial parotidectomy as first choice for parotid tumours. Chir Ital; 2007 Jan-Feb;59(1):91-7
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  • [Title] Superficial parotidectomy as first choice for parotid tumours.
  • Parotid neoplasms represent 3% of all head and neck tumours, and most are benign.
  • Malignant tumours account for 14-25% of cases.
  • Sixteen patients presented with a history of a painless parotid lump.
  • Diagnosis was achieved by ultrasound scan and MRI.
  • At histology, 10 pleomorphic adenomas, 4 Warthin's tumours, 1 lymphoepithelial cyst and 1 sebaceous adenocarcinoma were detected.
  • During follow-up ranging from 3 to 96 months no tumour recurrence was recorded.
  • Superficial parotidectomy seems to be the best choice of treatment for benign parotid tumours, since it allows complete excision of the tumour with sparing of the facial nerve.
  • [MeSH-major] Parotid Neoplasms / surgery. Salivary Gland Fistula / surgery

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  • (PMID = 17361936.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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99. Tamai K, Koyama T, Saga T, Kido A, Kataoka M, Umeoka S, Fujii S, Togashi K: MR features of physiologic and benign conditions of the ovary. Eur Radiol; 2006 Dec;16(12):2700-11
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  • [Title] MR features of physiologic and benign conditions of the ovary.
  • In reproductive women, various physiologic conditions can cause morphologic changes of the ovary, resembling pathologic conditions.
  • Benign ovarian diseases can also simulate malignancies.
  • Magnetic resonance imaging (MRI) can play an important role in establishing accurate diagnosis.
  • Functional cysts should not be confused with cystic neoplasms.
  • Multicystic lesions that may mimic cystic neoplasms include hyperreactio luteinalis, ovarian hyperstimulation syndrome, and polycystic ovary syndrome.
  • Recognition of clinical settings can help establish diagnosis.
  • In endometrial cysts, MRI usually provides specific diagnosis; however, decidual change during pregnancy should not be confused with secondary neoplasm.
  • Peritoneal inclusion cysts can be distinguished from cystic neoplasms by recognition of their characteristic configurations.
  • Ovarian torsion and massive ovarian edema may mimic solid malignant tumors.
  • In pelvic inflammatory diseases, transfascial spread of the lesion should not be confused with invasive malignant tumors.
  • Many benign tumors, including teratoma, Brenner tumor, and sex-cord stromal tumor, frequently show characteristic MRI features.
  • Knowledge of MRI features of these conditions is essential in establishing accurate diagnosis and determining appropriate treatment.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Ovarian Diseases / diagnosis. Ovary / anatomy & histology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 16736136.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 44
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100. Yang JH, Shi YF, Cheng Q, Qian YL: [Protein and mRNA expression of aquaporin-1 in epithelial ovarian tumors and its clinic significance]. Zhonghua Fu Chan Ke Za Zhi; 2005 Sep;40(9):623-6
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  • [Title] [Protein and mRNA expression of aquaporin-1 in epithelial ovarian tumors and its clinic significance].
  • OBJECTIVE: To investigate protein and mRNA expression of aquaporin-1 (AQP1) in epithelial ovarian tumors and its clinic significance.
  • METHODS: The protein and mRNA expressions of AQP1 were measured by immunohistochemical technique, western blot and RT-PCR in 65 cases of epithelial ovarian tumors and 13 cases of normal ovary tissue.
  • The protein and mRNA expressions of AQP1 in ovarian cancer (0.39 +/- 0.12, 0.93 +/- 0.51, respectively) and ovarian borderline tumors (0.43 +/- 0.21, 0.95 +/- 0.34, respectively) were significantly higher than that of ovarian benign tumors (0.27 +/- 0.13, 0.51 +/- 0.41, respectively; P < 0.05) and normal ovary tissue (0.24 +/- 0.13, 0.34 +/- 0.29, respectively; P < 0.05).
  • CONCLUSION: Over-expression of AQP1 plays an important role in development of epithelial ovarian tumors, and may be related with formation of ascites of ovarian carcinoma.
  • [MeSH-major] Aquaporin 1 / genetics. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Blotting, Western. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16202320.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 146410-94-8 / Aquaporin 1
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