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1. Yener U, Bayrakli F, Vardereli E, Sav A, Peker S: Intradiploic meningioma mimicking calvarial metastasis: case report. Turk Neurosurg; 2009 Jul;19(3):297-301
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  • Meningiomas are the most common benign intracranial neoplasms.
  • Nearly 20% of all primary intracranial tumors are meningiomas.
  • Although rare, these tumors can be found to occur in unexpected areas of the head and neck.
  • The possibility of an intraosseous meningioma mimicking a metastatic tumor should be kept in mind.

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  • (PMID = 19621299.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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2. Mannelli M, Simi L, Ercolino T, Gaglianò MS, Becherini L, Vinci S, Sestini R, Gensini F, Pinzani P, Mascalchi M, Guerrini L, Pratesi C, Nesi G, Torti F, Cipollini F, Bernini GP, Genuardi M: SDH mutations in patients affected by paraganglioma syndromes: a personal experience. Ann N Y Acad Sci; 2006 Aug;1073:183-9
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  • Mutations in genes encoding mitochondrial succinate dehydrogenase (SDH) are frequently involved in the development of neural crest-derived (NCD) tumors, such as pheochromocytomas (PHEOs) or paragangliomas (PGLs).
  • Affected patients showed high clinical variability, ranging from monolateral to bilateral glomus tumors, variably associated or not with PGLs or PHEOs.
  • A new missense G106D mutation, involving a highly conserved amino acid, was found in two sisters affected by bilateral glomus tumors.
  • A P81L mutation associated with abdominal and head and neck PGL was detected in three families.
  • A novel IVS2-1G>T variant was found at intron 2 of SDHD gene in one patient affected by a glomus tumor.
  • All the tumors associated with SDHD mutations were benign.

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  • (PMID = 17102085.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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3. Veras E, Sturgis EM, Luna MA: Heterotopic parathyroid inclusion in a cervical lymph node. Head Neck; 2007 Dec;29(12):1160-3
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  • BACKGROUND: During the pathologic examination of neck dissection specimens, unexpected findings within the lymph nodes may be discovered.
  • Such findings may include benign epithelial inclusions, a second primary tumor, or chronic inflammatory diseases.
  • METHODS: We report a case of a 59-year-old man who underwent a laryngectomy and bilateral neck dissection for a right transglottic squamous carcinoma of the larynx.
  • RESULTS: Histologic examination of the neck dissection specimen revealed benign parathyroid inclusions in the enlarged lymph node.
  • [MeSH-minor] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Humans. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Laryngectomy. Male. Middle Aged. Neck Dissection

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  • (PMID = 17615563.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Tian W, Li X, Li D, Liu X, Lin S, Liang Y: [Imageology features and transoral approach of benign parapharyngeal space tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Nov;24(21):983-6
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  • [Title] [Imageology features and transoral approach of benign parapharyngeal space tumors].
  • OBJECTIVE: To analyze the imageology features of benign parapharyngeal space (PPS) tumors, and also to summarize our experience in removing PPS benign tumors through transoral approach.
  • METHOD: A retrospective review was conducted to 48 patients with benign tumors in PPS during a 10-year period.
  • RESULT: CT scan and MRI often provided complementary information to help the surgeons delineate the size, precise location and likely cause of these tumors.
  • The transoral approach described herein safely allowed for en bloc resection of most benign neoplasms.
  • CONCLUSION: CT or MRI scan can distinguish prestyloid from poststyloid lesions, and to assess the extension of the tumor as well as its relationship with adjacent structures.
  • The transoral approach safely provides access to some benign PPS tumors with a low rate of complications and recurrence as well as traditional transcervical approaches.

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  • (PMID = 21261019.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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5. El-Hadi T, Oujilal A, Boulaich M, Sqalli L, Kzadri M: Plemorphic adenoma of the infratemporal space: a new case report. Int J Otolaryngol; 2009;2009:529350
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  • Plemorphic adenoma is a frequent benign tumor of the major salivary glands.

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  • [Cites] Auris Nasus Larynx. 2003 Dec;30(4):417-20 [14656569.001]
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  • (PMID = 20169128.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2821647
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6. Khademi B, Kazemi T, Bayat A, Bahranifard H, Daneshbod Y, Mohammadianpanah M: Salivary gland myoepithelial neoplasms: a clinical and cytopathologic study of 15 cases and review of the literature. Acta Cytol; 2010 Nov-Dec;54(6):1111-7
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  • OBJECTIVE: To describe the clinical and cytopathologic findings in 15 cases of salivary gland myoepithelial neoplasms and to assess the value of fine needle aspiration in the diagnosis of these tumors.
  • STUDY DESIGN: Between 2000 and 2007, 15 consecutive patients were diagnosed with benign and malignant myoepithelioma of the head and neck region.
  • There were 10 benign and 5 malignant myoepitheliomas.
  • In the benign group, only in 1 case did fine needle aspiration (FNA) revealed benign spindle cell variant, and in others, FNA diagnosis was mixed tumor.
  • The predominant cell morphology in the benign group was plasmacytoid cells, followed by a spindle and clear cell population.
  • Scant fibrillary myxoid material was observed in both benign and malignant specimens.
  • In addition, 39% of all tumors were malignant, and parotid gland consisted of 45% of all primary sites.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Parotid Neoplasms / metabolism. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 21428157.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600
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  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • It is typically located in the extremities, and less frequently in head-neck region, trunk, and various organs.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Heinrich UR, Brieger J, Gosepath J, Wierzbicka M, Sokolov M, Roth Y, Szyfter W, Bittinger F, Mann WJ: Frequent chromosomal gains in recurrent juvenile nasopharyngeal angiofibroma. Cancer Genet Cytogenet; 2007 Jun;175(2):138-43
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor, mostly affecting adolescent males.
  • Four patients with one or two recurrences were included in the study; for one of these, no material of the primary tumor was available for analysis.
  • Sex chromosomes were frequently affected in both primary tumors and recurrences.
  • There was no correlation among tumor staging, age, and DNA amplification.
  • No DNA aneuploidy was detected, a finding in accordance with the generally benign characteristics of JNAs.
  • Our observations suggest that in JNA the activation of oncogenes is more likely than the inactivation of tumor suppressor genes.
  • Autosomal gains in the primary tumor should be further evaluated as markers for a potentially increased risk of recurrence after surgical removal in this entity.
  • [MeSH-major] Angiofibroma / genetics. Chromosome Aberrations. Nasopharyngeal Neoplasms / genetics. Neoplasm Recurrence, Local / genetics

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  • (PMID = 17556070.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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9. Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P: Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg; 2006 Jul;132(7):788-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To address questions about the etiology, behavior, optimal treatment, and prognosis of metastasizing pleomorphic adenoma (MPA), we undertook a review of the literature (1953-2005) and constructed a virtual series of all identified cases of MPA, metastatic lesions that are very occasionally identified in patients with a history of pleomorphic salivary adenoma and, on detailed pathological evaluation, found to exhibit all the histological hallmarks of the preceding benign lesions.
  • Bone was the most common site for metastases (45%), followed by the head and neck (43%) and lung (36%).
  • Developing distant lesions within 10 years of the primary tumor and presence of metastases in multiple sites were independent predictors of survival on Cox regression analysis.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Proportional Hazards Models. Survival Analysis. Treatment Outcome

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  • (PMID = 16847191.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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10. Sirivella S, Gielchinsky I: Chondroid syringoma: a rare tumor of the chest wall. Ann Thorac Surg; 2010 Mar;89(3):983-5
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  • [Title] Chondroid syringoma: a rare tumor of the chest wall.
  • Chondroid syringoma, an uncommon, slow-growing, benign, sweat-gland tumor located on the upper right chest wall of a 66-year-old woman is presented.
  • This skin adenexal tumor is typically located on the head and neck region.
  • Total surgical excision remains the best therapeutic option to avoid tumor recurrence and close follow-up is recommended because of a rare possibility of malignant transformation and visceral metastases.

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172178.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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11. Jiang WH, Xie ZH, Xiao JY, Zhang H, Zhao SP: [Prevention and management of complications of endoscopic surgery for nasal-skull base neoplasms]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Feb;43(2):84-8
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  • METHODS: One hundred and thirty two patients with nasal-skull base tumors undergoing endoscopic or endoscope-assisted surgery were included in this study.
  • These approaches were selectively used to resect the tumors in the area of nasal-skull base.
  • RESULTS: The total resection of the tumors was obtained in 104 patients (104/132, 78.8%), with 29.5% (39/132) incidence of complications, including profuse bleeding, nerve injury, cerebrospinal fluid leakage, diabetes insipidus, electrolyte imbalance, hyperglycemia, and psychological disturbance.
  • Four months to 8 years' follow up (median 3.0 years) indicated that recurrence rate of the benign tumor was 9% (9/100) without died case, and 3-year and 5-year survival rates of the malignant tumor were 75.0% and 55.6%, respectively.
  • The strategies were as follows: first, according to original site, extension and characteristics of the tumor, designing appropriate endoscopic approaches for the treatment of skull base tumor; second, recognizing reliable surgical access points and safe plane of the dissection; third, predicting surgical risks preoperatively and proposing the corresponding plan to avoid these risks; fourth, acquainted with the endoscopic skills and familiarized the skull base structures; lastly, ensuring the correct management of the interdisciplinary problems with close collaboration with the interdisciplinary medical personnels.

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  • (PMID = 18510209.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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12. Wygledowska-Kania M, Kamińska-Winciorek G, Krauze E, Brzezińska-Wcisło L, Kajor M: Multifocal type of pilomatrixoma. Adv Med Sci; 2007;52:251-3
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  • Pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • The skin lesion occurs usually as a solitary tumor and the multifocal types are very rare.
  • Skin changes can be described as a firm to hard, non-painful, oval-shaped tumor that is covered by normal skin.
  • It commonly occurs on a scalp, face, neck and rarely back and extremities.
  • In this paper case of 16-years-old male patient with many solid tumors in subcutaneous tissue on both arms will be reported.

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  • (PMID = 18217427.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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13. Magliulo G, Colicchio G, Romana AF, Stasolla A: Intracochlear schwannoma. Skull Base; 2010 Mar;20(2):115-8
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  • Intralabyrinthine schwannomas are benign, slow-growing tumors that originate from Schwann cells lining the terminal ends of the cochlear and vestibular nerves.
  • Kennedy et al proposed a classification system, based upon the MRI observations, that identifies seven different classes according to the site of the tumor: intravestibular, intracochlear, intravestibulocochlear, transmodiolar, transmacular, transotic, and tympanolabyrinthine.

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  • (PMID = 20808537.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853071
  • [Keywords] NOTNLM ; Intralabyrinthine schwannoma / MRI / follow-up / surgery
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14. Leitner Y, Shabat S, Boriani L, Boriani S: En bloc resection of a C4 chordoma: surgical technique. Eur Spine J; 2007 Dec;16(12):2238-42
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  • The prognosis of aggressive benign and low-grade malignant tumors in the spine as in the limbs, seems to be mostly related to the feasibility of en bloc resection, while in the treatment of high-grade malignant tumors the protocols of treatment include the combination of chemotherapy, radiation and surgery.
  • In the cervical spine few cases are reported of resection, due not only to anatomical constraint, but also to the rarity of finding a tumor accomplishing the criteria of feasibility.
  • The anterior approach consisted of contemporary right and left prevascular presternocleidomastoid approaches The specimen was submitted for the histological study of the margins, which resulted tumor-free.
  • This technical note is finalized to confirm that en bloc resection of the vertebral body through total vertebrectomy is feasible in the midcervical spine by double approaches, provided the tumor involves only layers B and C, maximum extension sectors 5-8.
  • [MeSH-minor] Adult. Decompression, Surgical / instrumentation. Decompression, Surgical / methods. Humans. Internal Fixators. Laminectomy / instrumentation. Laminectomy / methods. Magnetic Resonance Imaging. Male. Neck / anatomy & histology. Neck / surgery. Neck Pain / pathology. Neck Pain / physiopathology. Neck Pain / surgery. Radiculopathy / etiology. Radiculopathy / physiopathology. Radiculopathy / surgery. Spinal Cord Compression / etiology. Spinal Cord Compression / physiopathology. Spinal Cord Compression / surgery. Spinal Fusion / instrumentation. Spinal Fusion / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17713796.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2140125
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15. Mendes RA, Carvalho JF, van der Waal I: Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment - an overview. Oral Oncol; 2010 Jan;46(1):19-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment - an overview.
  • In the classification of Head and Neck Tumors, published in 2005 by the World Health Organization Classification, the odontogenic keratocyst has been reclassified as a benign intraosseous neoplasm, calling it "keratocystic odontogenic tumor" (KCOT).
  • Genetic and molecular research regarding odontogenic tumors, and KCOTs in particular, has led to an increasing amount of knowledge and understanding of their physiopathological pathways.
  • A review of the biological behavior of this recognized aggressive pathological entity of the jaws and a contemporary outline of the molecular (growth factors, p53, PCNA and Ki-67, bcl-2) and genetic (PTCH, SHH) alterations associated with this odontogenic neoplasm provides a better understanding of the mechanisms involved in its development and strengthen the current concept that the KCOT should, indeed, be regarded as a neoplasm.
  • Furthermore, markers known to be rapidly induced in response to growth factors, tumor promoters, cytokines, bacterial endotoxins, oncogenes, hormones and shear stress, such as COX-2, may also shed new light on the biological mechanisms involved in the development of these benign but sometimes aggressive neoplasms of the jaws.
  • [MeSH-major] Jaw Neoplasms. Odontogenic Cysts. Odontogenic Tumors

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  • (PMID = 20004133.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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16. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14
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  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • PURPOSE: Emerging technologies allow surgeons to diagnose and treat osseous neoplasms while minimizing the collateral damage caused by surgical exposure and tumor excision.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • METHODS: Stereotactic imaging and intraoperative guidance was used as an adjunct to tumor care in these patients.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • RESULTS: Computer-assisted stereotactic localization allowed us to successfully ablate these lesions from their anatomically challenging locations, without disrupting the shoulder girdle or neck musculature, and without extensive bony resection.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Zhou Q, Zheng JW: [Research advances in molecular biology of carotid body tumor]. Shanghai Kou Qiang Yi Xue; 2009 Apr;18(2):218-22
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  • [Title] [Research advances in molecular biology of carotid body tumor].
  • The carotid body (CB) is a highly specialized small organ located at the bifurcation of the common carotid artery in the neck and plays an important role in acute adaptation to hypoxia, which is the most common tumor site in head and neck paragangliomas.
  • Although carotid body tumors (CBTs) are mostly slow-growing and benign, they can cause significant morbidity because of their proximity to major arteries and nerves in the head and neck.
  • Currently, inactivating germline mutations in the mitochondrial complex II subunits SDHB, SDHC, and SDHD have been identified as genetic risk factors for CB tumors (CBTs).
  • [MeSH-major] Carotid Body Tumor. Paraganglioma

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  • (PMID = 19418004.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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18. Jana AK, Jaswal A, Sikder B, Jana U, Nandi TK: Surgical management of parapharyngeal tumors - our experience. Indian J Otolaryngol Head Neck Surg; 2008 Dec;60(4):345-8
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  • [Title] Surgical management of parapharyngeal tumors - our experience.
  • Fifteen cases of parapharyngeal tumors treated surgically in ENT department of Calcutta National Medical College in last 2 years were included, 80% cases were of benign tumors, most common being schwannomas.
  • The study gives an overview regarding the surgical approach, based upon the extent and histology of the tumor and transcervical approach was found to be most efficient for all practical purpose.

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  • [Cites] Otolaryngol Clin North Am. 1977 Jun;10(2):421-6 [197466.001]
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  • (PMID = 23120578.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3476807
  • [Keywords] NOTNLM ; Parapharyngeal tumors / Surgical management
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19. Zhou YA, Huang JH, Wan CY, Zuo ZB: [Surgical treatment and effect observation of cervical intraspinal benign neoplasms]. Zhongguo Gu Shang; 2009 Nov;22(11):856-8
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  • [Title] [Surgical treatment and effect observation of cervical intraspinal benign neoplasms].
  • OBJECTIVE: To investigate the diagnosis, surgical procedure and clinical outcome of cervical intraspinal benign neoplasm.
  • Symptoms mainly included neck pain, numbness and weakness of the extremities, urinary and fecal incontinence, pyramid signs, etc.
  • The tumors were removed completely in 18 cases, above 60% in 3 cases and 25% with biopsy in 1 case.
  • Cervical stability in 11 cases was restored after removal of tumors.
  • CONCLUSION: The surgical exairesis for cervical intraspinal benign neoplasm has low post-operative recurrence.
  • The main reason of recurrence is not removed the tumor completely.

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  • (PMID = 20084949.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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20. Pontes HA, Pontes FS, Cruz e Silva BT, Fonseca FP, Carneiro JT Jr, Paiva HB, Pinto Ddos S Jr: Solitary neurofibroma of the temporal bone. J Craniofac Surg; 2010 Nov;21(6):1984-7
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  • Neurofibroma is a benign peripheral nerve sheath tumor that can be occasionally found in the head and neck region as multiple lesions associated with neurofibromatosis type 1 (NF-1) or as a solitary tumor.

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  • (PMID = 21119477.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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21. Lanza A, Moscariello A, Villani R, Colella G: Glomus tumor of the lower lip. A case report. Minerva Stomatol; 2005 Nov-Dec;54(11-12):687-90
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  • [Title] Glomus tumor of the lower lip. A case report.
  • A glomus tumor is a benign neoplasm originating from the modified smooth muscle cells of the vascular glomus.
  • This neoplasm was firstly considered by Masson in 1924, and generally it has a solitary lesions but in some cases multiple lesions were described.
  • The clinical case of a 65-year-old man with a glomus tumor of the lower lip is described.
  • [MeSH-major] Glomus Tumor / pathology. Lip Neoplasms / pathology

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  • (PMID = 16456522.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Ali TZ, Epstein JI: Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2007 May;31(5):697-705
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  • Infiltration around benign glands was seen in 10 (36%) cases, with predominantly small nests and AC-P.
  • Invasion of thick muscle bundles of the bladder neck was seen in 10 of 21 TURP cases.
  • An additional 11 cases showed extraprostatic extension on TURP with bladder neck invasion (n=10) or periprostatic adipose tissue invasion (n=1).
  • Basal cell carcinomas are rare tumors with a broad morphologic spectrum.
  • These tumors predominantly show an indolent course with local infiltrative behavior.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biopsy, Needle. Combined Modality Therapy. Humans. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Retrospective Studies. Transurethral Resection of Prostate

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  • (PMID = 17460452.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Braun S, Riemann K, Kupka S, Leistenschneider P, Sotlar K, Schmid H, Blin N: Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomas. Anticancer Res; 2005 Jul-Aug;25(4):2809-14
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  • BACKGROUND: Paragangliomas are benign, slow-growing tumours of the head and neck region.
  • MATERIALS AND METHODS: Normal and tumour DNA of 17 patients with sporadic paragangliomas were analysed by sequencing (SDHD, SDHB and SDHC genes), fluorescence in situ hybridisation (FISH).
  • LOH and FISH analysis demonstrated a frequent loss of regions within chromosome 11, indicating that additional genes in 11q may play a role in tumour genesis of sporadic paragangliomas.
  • [MeSH-minor] Carotid Body Tumor / enzymology. Carotid Body Tumor / genetics. Chromosomes, Human, Pair 11 / genetics. Glomus Jugulare Tumor / enzymology. Glomus Jugulare Tumor / genetics. Glomus Tympanicum Tumor / enzymology. Glomus Tympanicum Tumor / genetics. Humans. In Situ Hybridization, Fluorescence. Loss of Heterozygosity. Mutation. Paraffin Embedding

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  • (PMID = 16080530.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / SDHD protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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24. Lian X, Zhao J, Hou T, Ma H, Chen Z: Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report. Spine (Phila Pa 1976); 2006 Nov 1;31(23):E895-9
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  • [Title] Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report.
  • STUDY DESIGN: A case report of a rare benign osteoblastoma successfully treated with total en bloc excision.
  • SUMMARY OF BACKGROUND DATA: A rare case of massive benign osteoblastoma stemming from left side lamina of C7 and extension to spinal canal from C6 to T1 resulting in spinal cord compressed severely is reported.
  • METHODS: A 13-year-old girl complained of gradually increasing pain of her lower part of the neck and left shoulder radiating to the left upper extremity, and the neurologic deficits were found in physical examination.
  • A massive neoplasm located in intraspinal cervicothoracic junction and the spinal cord compressed severely was shown in radiographs, MRI, and CT.
  • The neoplasm was removed totally with instrumentation performed in surgical intervention.
  • Recurrence of the tumor was not seen at the final follow-up.

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  • (PMID = 17077728.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
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  • [Title] Recurrent granular cell tumor: how to treat.
  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The patient was a 16-year-old girl with a 3-year history of a painless mass on the right side of her neck.
  • The mass was excised two times at different centers and diagnosed as granular cell tumor after the pathologic examination.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Jiang Y, Chen Y, Gao L, Ye Q, Alonso MA: [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 May;23(10):451-3
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  • [Title] [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx].

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  • (PMID = 19670627.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / MAL protein, human; 0 / Membrane Transport Proteins; 0 / Myelin Proteins; 0 / Myelin and Lymphocyte-Associated Proteolipid Proteins; 0 / Proteolipids
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27. Baloch ZW, LiVolsi VA: Microcarcinoma of the thyroid. Adv Anat Pathol; 2006 Mar;13(2):69-75
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  • Thyroid microcarcinoma, defined as a thyroid tumor measuring 1 cm or less, is an extremely indolent tumor.
  • Papillary microcarcinoma, the most common subtype, is often identified incidentally in a thyroid removed for benign clinical nodules or diffuse processes (eg, thyroiditis).
  • In the less common scenario, the microcarcinoma is the primary lesion to a lymph node metastasis presenting clinically as a neck mass; in this situation, the tumor should be treated as a clinical cancer.
  • However, when found as sporadic tumors, their implications are still unknown.

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  • (PMID = 16670460.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 84
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28. Saunders SE, Conjeski JM, Zaslau S, Williams J, Kandzari SJ: Leiomyoma of the urinary bladder presenting as urinary retention in the female. Can J Urol; 2009 Aug;16(4):4762-4
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  • A case of leiomyoma of the urinary bladder, a rare benign tumor, in a 56-year-old female first seen with bilateral flank pain radiating to both groins, is reported.
  • The mass was prolapsing as a ball valve into the urethra at the level of the bladder neck.

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  • (PMID = 19671234.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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29. Thakur JS, Mohindroo NK, Mohindroo S, Sharma DR, Thakur A: Pleomorphic adenoma of minor salivary gland with therapeutic misadventure: a rare case report. BMC Ear Nose Throat Disord; 2010;10:2
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  • BACKGROUND: The benign tumors of nasopharynx are least encountered tumors in otolaryngology, as nasopharynx is considered one of notorious anatomical site for the malignant tumors.
  • On CT scan, this tumor was quite big and extending to the parapharyngeal space.
  • The excision biopsy of tumor revealed it as pleomorphic adenoma.
  • We found only five published reports on this tumor arising from nasopharynx.
  • DISCUSSION AND CONCLUSION: Although, in this case report exact origin of the tumor could not be ascertained as it also appeared to be a parapharyngeal tumor but we kept the possibility of a nasopharyngeal tumor on the basis of clinical features.
  • It can be misdiagnosed as malignant epithelial tumor on histopathology.
  • A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.

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  • (PMID = 20157428.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2821363
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30. Jokinen CH, Wolgamot GM, Argenyi ZB: Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin. J Cutan Pathol; 2008 Feb;35(2):215-9
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  • [Title] Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin.
  • Schwannoma and neurofibroma account for the majority of cutaneous benign peripheral nerve sheath tumors and usually pose little diagnostic difficulty in their classic forms.
  • In rare instances, however, benign peripheral nerve sheath tumors may display epithelioid morphology and lack otherwise usual features of schwannoma or neurofibroma, making classification difficult.
  • These unusual changes may prompt consideration of other benign neoplasms or a malignancy.
  • Benign epithelioid peripheral nerve sheath tumor (BEPNST) is a somewhat non-specific term recently proposed to describe these neoplasms of imprecise histogenesis.
  • Specifically, the neoplastic cells in this tumor were nearly obscured by the collagen, which formed large nodules and compressed the majority of the few remaining tumor cells to the periphery of the lesion.
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Neck / pathology

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  • (PMID = 18190449.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9007-34-5 / Collagen
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31. Kambham N, Kong C, Longacre TA, Natkunam Y: Utility of syndecan-1 (CD138) expression in the diagnosis of undifferentiated malignant neoplasms: a tissue microarray study of 1,754 cases. Appl Immunohistochem Mol Morphol; 2005 Dec;13(4):304-10
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  • However, it has not been widely tested in non-hematolymphoid tissues, and thus its utility in the setting of an undifferentiated malignant neoplasm has not been evaluated.
  • The authors conducted an extensive study of CD138 staining in over 1,700 normal, benign, and malignant non-hematolymphoid tissues, using five tissue microarrays.
  • In addition to the specific membrane staining, many normal tissues and epithelial tumors showed strong cytoplasmic immunoreactivity.
  • In squamous cell carcinoma of the head and neck, renal cell carcinoma, and prostate adenocarcinoma, the intensity of CD138 staining inversely correlated with the histologic grade of the carcinoma.
  • The authors conclude that the expression of syndecan-1, although relatively specific to plasma cells within the hematolymphoid system, should be interpreted with extreme caution in the setting of an undifferentiated neoplasm.
  • Furthermore, the two commercially available monoclonal CD138 antibodies tested in this study showed significant differences in their immunoreactivity in different tumor types.

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  • (PMID = 16280658.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / Proteoglycans; 0 / SDC1 protein, human; 0 / Syndecan-1; 0 / Syndecans
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32. Subhashraj K, Balanand S, Pajaniammalle S: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal; 2009 Jan;14(1):E12-4
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  • Schwannoma is an intraoral rare, benign neoplasm derived from the nerve sheath of peripheral nerves.
  • Ancient schwannoma of the head and neck region is relatively uncommon and very few cases had been reported in the oral cavity.
  • Ultrasonography showed that the tumor was closely associated with the mental nerve on the left side, suggestive of a peripheral neural sheath tumor.

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  • (PMID = 19114949.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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33. Wang CP, Lee YC, Lou PJ, Yang TL, Chen TC, Huang CC, Ko JY: Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer. Oral Oncol; 2009 Jul;45(7):615-20
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  • [Title] Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer.
  • Dysphagia is not uncommon after curative treatment for primary head and neck cancer.
  • The purpose of this study was to prospectively investigate the diagnostic value of unsedated transnasal esophagogastroduodenoscopy (EGD) in 36 primary head and neck cancer patients with post-treatment dysphagia.
  • Except three patients with very narrow space or the presence of the tumor in the neopharynx, transnasal EGD could completely evaluate the upper digestive tract in 33 patients and found one patient with local recurrent hypopharyngeal cancer, seven patients with newly diagnosed hypopharyngeal cancer, four patients with esophageal cancer, and one patient with simultaneous hypopharyngeal and esophageal cancers, which were all successfully biopsied and proven microscopically.
  • One patient had a benign tumor on the epiglottis and the other NPC patient had extensive soft tissue necrosis in the pyriform sinus as a cause of dysphagia.
  • The present study indicates that unsedated transnasal EGD is feasible to confidently distinguish between functionally/anatomically-related dysphagia and newly growing tumors in the upper digestive tract, and to obtain biopsy specimens for pathological diagnosis from the tumors in a single session.
  • [MeSH-major] Deglutition Disorders / diagnosis. Endoscopy, Digestive System / methods. Esophageal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Conscious Sedation. Feasibility Studies. Female. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Prospective Studies. Taiwan

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  • (PMID = 19027351.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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34. Ram H, Mohammad S, Husain N, Gupta PN: Ameloblastic carcinoma. J Maxillofac Oral Surg; 2010 Dec;9(4):415-9
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  • Ameloblastic carcinoma (AC) is a rare aggressive malignant epithelial odontogenic tumor of the maxillofacial skeleton with a distinct predilection in the mandible.
  • It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility.
  • Direct extension of the tumour, lymph node involvement and metastasis to various sites has been reported.

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  • (PMID = 22190836.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177477
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Ameloblastoma / Odontogenic tumor
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35. Unlu HH, Songu M, Ovali GY, Nese N: Inverted papilloma with new bone formation: report of three cases. Am J Rhinol; 2007 Sep-Oct;21(5):607-10
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  • BACKGROUND: An inverted papilloma (IP) is a benign sinonasal tumor of ectodermal origin, which is locally aggressive and destructive, tends to recur if incompletely removed, and has significant malignant potential.
  • We also believe that additional investigations are required to characterize the pathophysiological mechanisms involved in neoplasm-induced osteogenesis.

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  • (PMID = 17999798.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • The final treatment of these tumors is surgical.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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37. Perrotti V, Rubini C, Fioroni M, Iezzi G: Pleomorphic lipoma of the oral cavity. Report of a case. Minerva Stomatol; 2006 May;55(5):321-5
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  • Pleomorphic lipoma (PL) is a rare benign tumor mainly located in the upper back, upper shoulders, and back of the neck in elderly men.
  • More rarely it is located in the head and neck region and in the oral cavity.
  • Local excision is adequate for PL and the tumor does not recur.

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  • (PMID = 16688109.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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38. Göktas O, Lammert I: [Neurilemmoma of the head and neck--report of 3 cases]. Laryngorhinootologie; 2006 Aug;85(8):582-5
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  • [Title] [Neurilemmoma of the head and neck--report of 3 cases].
  • BACKGROUND: Neurilemmoma are benign tumors of the nerve-sheath, also known as schwannoma.
  • Beside intracranial manifestation, neurilemmoma are found at other peripheral nerves of the head and neck.
  • The histological examination showed two types of Antoni-A-neurilemmoma, whereas one tumor was found with mixed type A and B-neurilemmoma.
  • CONCLUSION: Although extracranial neurilemmoma of retropharygeal space, neck or supraglottic larynx are rare tumors, neurilemmoma should be involved in differential diagnosis of tumors in these areas.

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  • (PMID = 16883493.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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39. Storck C, Savic S, Egli J, Fischer C, Wolfensberger M: [Granular cell tumor of the larynx: a case report]. HNO; 2008 Dec;56(12):1229-32
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  • [Title] [Granular cell tumor of the larynx: a case report].
  • Granular cell tumors are benign subcutaneous or submucosal lesions of neurogenic origin.
  • They are quite commonly found in the head and neck region, particularly in the tongue.
  • However, only about 200 cases of laryngeal granular cell tumors have been reported so far.
  • Most laryngeal granular cell tumors are located in the posterior part of the vocal fold and in the posterior commissure.
  • However, tumor extension and expected morbidity of the surgery will inevitably influence the extent of the resection.

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  • (PMID = 18340420.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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40. Hwang HS, Lee WJ, Lim HK, Chun HK, Ahn GH: Chondrolipoma in the pelvic cavity: a case report. Korean J Radiol; 2008 Nov-Dec;9(6):563-7
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  • A chondrolipoma is an extremely rare form of a benign mesenchymal tumor containing mature cartilage and fatty tissue.
  • Chondrolipomas may be found in almost any part of the body, particularly in the connective tissue of the breast, head and neck area, as well as in the skeletal muscle.

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  • (PMID = 19039275.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627234
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41. Jaidane M, Bouicha T, Slama A, Hmida W, Hidoussi A, Ben Sorba N, Mosbah F: Tumor recurrence in prostatic urethra following simultaneous resection of bladder tumor and prostate: a comparative retrospective study. Urology; 2010 Jun;75(6):1392-5
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  • [Title] Tumor recurrence in prostatic urethra following simultaneous resection of bladder tumor and prostate: a comparative retrospective study.
  • OBJECTIVES: To evaluate the effect on the oncological outcomes and recurrences at the prostatic urethra of simultaneous transurethral resection of bladder tumor (TURBT) and benign prostatic hyperplasia (TURP).
  • Clinicopathologic parameters, recurrence and progression rates, and recurrence rates in the bladder neck and prostatic urethra were determined and compared.
  • At a mean follow-up of 35.2 and 33.1 months in groups 1 and 2, respectively, only 1 patient developed recurrence in prostatic urethra or bladder neck in each group.
  • There were no statistically significant differences between the 2 groups in follow-up time, recurrence, progression or recurrence in the prostatic urethra, and bladder neck.
  • CONCLUSIONS: According to our results, simultaneous transurethral TURP and TURBT can be safely performed without increasing the risk of tumor recurrence in the prostatic urethra.
  • [MeSH-major] Cystectomy / methods. Neoplasm Recurrence, Local / epidemiology. Prostatic Hyperplasia / surgery. Transurethral Resection of Prostate / methods. Urinary Bladder Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Chi-Square Distribution. Cohort Studies. Combined Modality Therapy. Cystoscopy / methods. Follow-Up Studies. Humans. Immunohistochemistry. Incidence. Male. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Postoperative Complications / mortality. Postoperative Complications / pathology. Probability. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Rate. Treatment Outcome. Urethra / surgery

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19781747.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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42. Moosavi C, Jha P, Fanburg-Smith JC: An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD. Ann Diagn Pathol; 2007 Oct;11(5):313-9
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  • [Title] An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD.
  • The seminal article of Drs Franz Enzinger and Renyuan Zhang in 1988 defined plexiform fibrohistiocytic tumor (PFHT) as a distinctive entity.
  • These tumors were morphologically divided into 3 groups: fibroblastic, histiocytic (often with osteoclast-type giant cells), and mixed.
  • Most tumors exhibited a plexiform and infiltrative arrangement of cells at the dermal/subcutaneous junction.
  • Tumors were negative for S100 protein, desmin, cytokeratin, factor VIIIrag, and lysozyme.
  • Twenty-eight cases occurred in the upper extremity (mostly forearm), 16 in lower extremity, 11 in trunk, 9 in head and neck, and 2 of unknown site.
  • The tumors were generally positive for CD68 and SMA, occasionally for MSA, and negative for keratin, desmin, HMB45, S100 protein, and CD34.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17870015.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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43. Lee SH, Mah SY, Chung BH: Incidentally discovered inverted papilloma of the urinary bladder in patients with lower urinary tract symptoms. J Endourol; 2010 Feb;24(2):271-5
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  • BACKGROUND AND PURPOSE: Inverted urothelial papilloma (IP) is an uncommon urothelial neoplasm.
  • PATIENTS AND METHODS: From 1994 to 2008, 53 patients with urinary IP underwent transurethral resection of the bladder tumor (TURBT) at our institution.
  • In IP located on the bladder neck of patients with benign prostatic hyperplasia (BPH), significantly higher obstructive symptoms and larger prostate volumes than that of other located IP with BPH were observed.
  • Despite the absence of agreement of its etiology, its presenting symptoms were related to LUTS and benign prostatic enlargement.

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  • (PMID = 20039831.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR: p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol; 2007 Dec;1(2):123-31
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  • Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions.
  • Nineteen oncocytomas, 9 cases of oncocytosis, 9 oncocytic carcinomas and 16 head and neck metastatic RCC were studied.
  • Tumors were stained with antibodies to p63, renal cell carcinoma marker (RCCm), CD10, and vimentin.
  • Eight benign oncocytic tumors (29%) had clear cell features while 6 metastatic RCC (37%) had oncocytic features.
  • Mitotic rates were only significantly different between benign oncocytic tumors and metastatic RCC.
  • Seven benign oncocytic tumors (25%) and 5 oncocytic carcinomas (56%) had RCC-like vascular stroma.
  • All primary salivary gland tumors were positive for p63, predominately in basal cell-type distribution.
  • While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Predictive Value of Tests

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  • (PMID = 20614263.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2807526
  • [Keywords] NOTNLM ; Metastatic renal cell carcinoma / Oncocytic carcinoma / Oncocytoma / p63
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45. Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, Covello R, Spriano G: Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia; 2008 Jun;23(2):202-4
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  • Rhabdomyoma is an exceedingly rare soft tissue benign tumor of skeletal muscle origin classified into cardiac and extracardiac types based on location.
  • Adult rhabdomyomas are rare, but morphologically characteristic, benign mesenchymal tumors with mature skeletal muscle differentiation that in 90% of cases arise in the head and neck region, mainly in the mucosa of the oropharynx, nasopharynx, and larynx, from the branchial musculature of third and fourth branchial arches.
  • Usually presenting symptoms include upper airway obstruction, Eustachian tube dysfunction, and mucosal or neck mass, but rarely does it arise as pure dysphagia.

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  • (PMID = 17965913.001).
  • [ISSN] 0179-051X
  • [Journal-full-title] Dysphagia
  • [ISO-abbreviation] Dysphagia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Hong R, Choi DY, Do NY, Lim SC: Fine-needle aspiration cytology of a lipoblastoma: a case report. Diagn Cytopathol; 2008 Jul;36(7):508-11
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  • A lipoblastoma is a rare benign tumor of immature white fat, and more than 90% of lipoblastomas occur before the age of 3 years.
  • However, an accurate preoperative diagnosis is essential for the planning of surgery, particularly for a lesion of the head and neck area.
  • According to the cytological findings, the lesion was diagnosed as a benign adipose tumor suggestive of a lipoblastoma.
  • [MeSH-major] Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Lipoma / pathology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18528880.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Durr ML, Mydlarz WK, Shao C, Zahurak ML, Chuang AY, Hoque MO, Westra WH, Liegeois NJ, Califano JA, Sidransky D, Ha PK: Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One; 2010 May 26;5(5):e10828
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  • [Title] Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors.
  • BACKGROUND: Methylation profiling of tumor suppressor gene (TSGs) promoters is quickly becoming a powerful diagnostic tool for the early detection, prognosis, and even prediction of clinical response to treatment.
  • Few studies address this in salivary gland tumors (SGTs); hence the promoter methylation profile of various TSGs was quantitatively assessed in primary SGT tissue to determine if tumor-specific alterations could be detected.
  • METHODOLOGY: DNA isolated from 78 tumor and 17 normal parotid gland specimens was assayed for promoter methylation status of 19 TSGs by fluorescence-based, quantitative methylation-specific PCR (qMSP).
  • There was a variable frequency and individual methylation quotient detected, depending on the TSG and the tumor type.
  • When comparing normal, benign, and malignant SGTs, there was a statistically significant trend for increasing methylation in APC, Mint 1, PGP9.5, RAR-beta, and Timp3.
  • Further study is needed to evaluate the potential use of these associations in the detection, prognosis, and therapeutic outcome of these rare tumors.

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  • (PMID = 20520817.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / T32DC000027; United States / NCI NIH HHS / CA / 5P50CA096784-05; United States / NIDCR NIH HHS / DE / K08-DE018463; United States / NCI NIH HHS / CA / P50 CA096784; United States / NCI NIH HHS / CA / U01CA084986; United States / NIDCD NIH HHS / DC / T32 DC000027; United States / NIDCR NIH HHS / DE / K08 DE018463; United States / NCI NIH HHS / CA / U01 CA084986
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC2877085
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48. Roy MK, Joarder RH, Suruzzaman M, Kundu KK, Hossain MA, Alam MM, Sutradhar SR: Leiomyoma of the urinary bladder. Mymensingh Med J; 2005 Jul;14(2):209-11
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  • Benign mesenchymal tumors of the bladder are rare and comprise less than 1% of the all bladder neoplasms.
  • Leiomyoma is the most common type and comprises 35% of these tumors.
  • These tumors may develop in submucosal (63%), intramural (7%) or subserosal (30%) layer, at any region of the bladder.
  • Various examinations were performed in the last 2 years and was diagnosed either prostatic enlargement or bladder tumor.
  • The surgical exploration revealed a well-circumscribed mass at the bladder neck with moderate enlargement of the prostate.

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  • (PMID = 16056215.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
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49. Perez DE, Pires FR, Almeida OP, Kowalski LP: Epithelial lacrimal gland tumors: a clinicopathological study of 18 cases. Otolaryngol Head Neck Surg; 2006 Feb;134(2):321-5
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  • [Title] Epithelial lacrimal gland tumors: a clinicopathological study of 18 cases.
  • OBJECTIVE: The aim of this study was to report the clinicopathological features of 18 epithelial tumors of the lacrimal gland treated in a single institution.
  • RESULTS: Twelve tumors (66.7%) were adenoid cystic carcinoma (ACC), 5 (27.8%) pleomorphic adenoma (PA), and 1 (5.5%) carcinoma ex pleomorphic adenoma.
  • CONCLUSIONS: Epithelial lacrimal gland tumors are mainly PA and ACC, and malignancies are more common than benign tumors.
  • Although ACC presented typically with advanced clinical stage, 33% of the patients survived without tumor recurrence or metastasis.

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  • (PMID = 16455384.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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50. Gupta M, Chaudhary N: Pleomorphic adenoma of the base tongue. Indian J Otolaryngol Head Neck Surg; 2007 Dec;59(4):396-8
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  • Pleomorphic adenoma is the benign tumor of salivary glands.
  • This tumor is more common in major salivary glands.

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  • (PMID = 23120486.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452247
  • [Keywords] NOTNLM ; Salivary gland neoplasms / Tongue
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51. Linecker A, Kermer C, Sulzbacher I, Angelberger P, Kletter K, Dudczak R, Ewers R, Becherer A: Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival. Nuklearmedizin; 2008;47(2):80-5; quiz N12
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  • [Title] Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival.
  • The aim of the study was to determine the practicability of (18)F-FLT in tumours of the head and neck area in terms of visualization, a possible correlation between FLT uptake and proliferation fraction as determined by Ki-67 immunostaining, and if tumoural FLT-uptake has a prognostic meaning, as determined by a correlation to patient survival time.
  • PATIENTS, METHODS: 20 patients with previously untreated lesions of the head and neck area, which were clinically highly suspicious to be malignant, underwent PET scans with (18)F-FLT and (18)F-FDG, a CT of the head and neck area, and a biopsy.
  • Tumour tracer uptake was determined by standardized uptake value (SUV) normalized to body weight and /non-tumor ratios (T/N). (18)F-FDG and (18)F-FLT uptake were compared with histopathologic and immunohistochemical results.
  • RESULTS: 19 patients had malignant tumours; one patient had a benign cystadenoma (so called Warthin's tumour) of the parotid gland.
  • One negative lesion turned out to be a malignant T1 stage squamous cell carcinoma in both PET scans, the Warthin's tumour was false positive with (18)F-FDG but showed only faint uptake with (18)F-FLT, resulting in a sensitivity of 95 % for both tracers.
  • CONCLUSION: In head and neck cancer in the primary setting (18)F-FLT does not provide additional visual information in comparison to (18)F-FDG.(18)F-FLT uptake is inversely correlated with patient survival, as well as (18)F-FDG.
  • [MeSH-major] Dideoxynucleosides. Fluorodeoxyglucose F18 / pharmacokinetics. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / radionuclide imaging. Radioisotopes

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  • (PMID = 18392317.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dideoxynucleosides; 0 / Fluorine Radioisotopes; 0 / Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18; PG53R0DWDQ / alovudine
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52. Lenyoun EH, Wu JK, Ebert B, Lieberman B: Rapidly growing nodular fasciitis in the cheek of an infant: case report of a rare presentation. Eplasty; 2008;8:e30
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  • OBJECTIVE: Nodular fasciitis is a benign proliferative spindle-cell lesion found in the subcutaneous fascia that presents as a rapidly growing mass with rich cellularity and mitotic activity, leading to it frequently being mistaken for a sarcoma.
  • A small area of palpable tumor unable to be resected remained stable after 4 months of follow-up, and facial nerve function was preserved.
  • CONCLUSIONS: Although infrequent in both children and the oral mucosa, nodular fasciitis should be considered in the differential diagnosis of facial tumors in infants and young children.

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  • (PMID = 18587489.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / T35 HL007616
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2424278
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53. Demonte F, Moore BA, Chang DW: Skull base reconstruction in the pediatric patient. Skull Base; 2007 Feb;17(1):39-51
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  • Tumors of the skull base are rare in children and adolescents and present a complicated management problem for oncologists and surgeons alike.
  • Surgical resection is an integral component of the management of many pediatric neoplasms, especially those that are benign or, though not frankly malignant, are locally invasive.
  • The general principles of skull base reconstruction following tumor ablation are applicable to nearly all patients; the reconstructive algorithm, however, is particularly complex in the pediatric population and the potential benefits of therapy must be balanced against the cumulative impact on craniofacial growth and maturity and the donor site morbidity.
  • A retrospective analysis of all patients less than 19 years of age who underwent resection of a skull base tumor was performed.
  • Data were recorded on patient age, tumor pathology and location, prior therapies, surgical approach, extent of resection, margin status, defect components, details of reconstructive methods employed, complications, additional procedures or interventions, and the use and timing of adjuvant therapies.
  • On the basis of our experience and previous reports in the literature, we offer the following guidelines for the successful multidisciplinary care of children and adolescents undergoing skull base reconstruction after tumor resection:.

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  • (PMID = 17603643.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1852573
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54. Chen HJ, Chen HS, Chang YL, Huang YC: Complete unilateral maxillary sinus opacity in computed tomography. J Formos Med Assoc; 2010 Oct;109(10):709-15
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  • RESULTS: The most frequent diagnoses were as follows: chronic rhinosinusitis (52.6%), fungus ball (29.3%), antrochoanal polyp (2.6%), benign tumor (10.4%), and malignancy (5.1%).
  • CONCLUSION: Although unilateral maxillary sinus opacity is usually inflammatory in origin, fungal sinusitis and neoplastic disorder are also likely.
  • A careful history-taking, a thorough head and neck examination including nasal endoscopy, and CT evaluation are all imperative for reaching a correct diagnosis.

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  • [Copyright] Copyright © 2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20970067.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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55. Yeung AH, Sughrue ME, Kane AJ, Tihan T, Cheung SW, Parsa AT: Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitization. Neurosurg Focus; 2009 Dec;27(6):E2
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  • Vestibular schwannomas (VS) are benign tumors arising from the Schwann cells of cranial nerve VIII.
  • Although the side effect profile and rates of tumor control appear to be favorable for SRS, there is a subset of radioresistant tumors that continue to progress despite properly administered radiation treatment.
  • An improved understanding of the radiobiological behavior of VS may help guide appropriate patient selection for SRS and potentially aid in the design of novel therapies to treat radioresistant tumors.

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  • (PMID = 19951055.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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56. Chen L, Cui TT, Wang G, Li LY, Shi WY, Ni XX: [Intra-nasal scanning of tumors in nasal cavity and paranasal sinus with endoscopic ultrasonography]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Jan;42(1):23-6
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  • [Title] [Intra-nasal scanning of tumors in nasal cavity and paranasal sinus with endoscopic ultrasonography].
  • Twelve of them were benign tumors and 6 of them were malignant ones, which were confirmed by pathological examination of resected specimens.
  • On gray scale ultrasound, most masses were heterogeneous hypoechoic, tumors with rich blood vessels were lower hypoechoic, and some showed irregular anechoic area due to dilated vascular net.
  • A giant pituitary tumor eroding bone of sphenoid sinus and intruding into nasal cavity.
  • The rich blood supply was observed in fibroangioma, the rich flow signals and high velocity could be detected in malignant tumors.

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  • (PMID = 17432352.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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57. Saki N, Akhlagh SN, Mostofi NE, Ahmadi K: Chondrosarcoma of the hyoid bone: imaging, surgical, and histopathologic correlation. Laryngoscope; 2008 Jul;118(7):1211-3
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  • METHODS: We report one case of chondrosarcoma of the hyoid bone which presented with upper midline neck mass.
  • Patients with this disease have no sexual or racial preponderance, and most presented with a mass in the upper neck which has splotchy calcification in radiologic imaging without enhancement.
  • CONCLUSION: Because chondrosarcoma have indolent growth, are locally noninvasive, and appear encapsulated during operation, they may be mistaken for a benign mass and conservatively resected.
  • On the other hand, incomplete tumor resection may lead to recurrence, which is associated with increased risk of dedifferentiation and histologic grading of tumor.

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  • (PMID = 18475210.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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58. Hox V, Vander Poorten V, Delaere PR, Hermans R, Debiec-Rychter M, Sciot R: Extramammary myofibroblastoma in the head and neck region. Head Neck; 2009 Sep;31(9):1240-4
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  • [Title] Extramammary myofibroblastoma in the head and neck region.
  • BACKGROUND: Mammary myofibroblastoma is a benign mesenchymal tumor of the breast.
  • CONCLUSION: We describe this case because of the unusual location of this rare tumor.
  • SCL has a predilection site in the posterior neck.
  • Both tumors show the same clinical behavior, a close histological resemblance, and their cells are both immunoreactive for CD34 and CD10.
  • [MeSH-major] Head and Neck Neoplasms. Neoplasms, Muscle Tissue


59. Queimado L, Obeso D, Hatfield MD, Yang Y, Thompson DM, Reis AM: Dysregulation of Wnt pathway components in human salivary gland tumors. Arch Otolaryngol Head Neck Surg; 2008 Jan;134(1):94-101
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  • [Title] Dysregulation of Wnt pathway components in human salivary gland tumors.
  • OBJECTIVES: To determine the expression level of the Wnt components-WIF1 (Wnt inhibitory factor 1), WNT1, and beta-catenin-in salivary gland tumor cells and to investigate the mechanisms that contribute to activation of the Wnt pathway in human salivary gland tumors.
  • DESIGN: The expression of WIF1, WNT1, and beta-catenin in salivary gland normal tissue and tumor cell lines was analyzed by reverse transcription-polymerase chain reaction and Western blot analysis.
  • SUBJECTS: Samples were obtained from 6 normal salivary glands and 10 cell lines established from primary benign and malignant salivary gland tumors.
  • RESULTS: The expression of WIF1 was high in normal salivary gland tissue but was significantly down-regulated in all salivary gland tumor cell lines analyzed (P < .001).
  • The WIF1 rearrangements were recurrent but rare in salivary gland tumors.
  • Expression of WNT1 protein was undetectable in normal tissue but readily detectable by Western blot analysis in all salivary gland tumor cell lines. beta-Catenin messenger RNA expression was significantly up-regulated in salivary gland tumor cells.
  • CONCLUSIONS: This is the first report (to our knowledge) showing down-regulation of an antagonist of the Wnt pathway, WIF1, and up-regulation of a Wnt agonist, WNT1, in salivary gland tumor cells.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / metabolism. Blotting, Western. DNA-Binding Proteins / metabolism. Down-Regulation. Humans. Repressor Proteins / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured. Up-Regulation. beta Catenin / metabolism

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  • (PMID = 18209144.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR018741
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human; 0 / Repressor Proteins; 0 / WIF1 protein, human; 0 / Wnt Proteins; 0 / beta Catenin
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60. Velasco A, Palomar-Asenjo V, Gañan L, Catasus L, Llecha N, Panizo A, Palomar-Garcia V, Quer M, Matias-Guiu X: Mutation analysis of the SDHD gene in four kindreds with familial paraganglioma: description of one novel germline mutation. Diagn Mol Pathol; 2005 Jun;14(2):109-14
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  • The familial paraganglioma syndrome is an autosomal dominant disorder characterized by the presence of carotid body paragangliomas and, less frequently, paragangliomas of the glomus jugulare, glomus vagale, and adrenal pheochromocytomas.
  • DNA was obtained from tumor and normal tissue, as well as from peripheral blood.
  • The affected family members of the four kindreds showed paragangliomas, located in the head and neck region, and all of them were benign.
  • [MeSH-major] Germ-Line Mutation. Head and Neck Neoplasms / genetics. Membrane Proteins / genetics. Paraganglioma / genetics. Peripheral Nervous System Neoplasms / genetics

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  • (PMID = 15905695.001).
  • [ISSN] 1052-9551
  • [Journal-full-title] Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • [ISO-abbreviation] Diagn. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / SDHD protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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61. Power C, Kavanagh D, Hill AD, O'Higgins N, McDermott E: Unusual presentation of a giant parathyroid adenoma: report of a case. Surg Today; 2005;35(3):235-7
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  • Certain symptoms and biochemical abnormalities alert the surgeon to their presence, since these benign tumors are rarely evident on physical examination.
  • Moreover, because they are usually very small, preoperative localization using sestamibi scanning or ultrasonography is required to avoid bilateral neck exploration.
  • Interestingly, despite its huge size it did not cause many of the hypercalcemic symptoms usually associated with larger adenomas, but rather it manifested with symptoms of local pressure, another unusual property of this atypical tumor.
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Hyperparathyroidism / diagnosis. Hyperparathyroidism / etiology. Immunohistochemistry. Ireland. Neoplasm Staging. Parathyroidectomy / methods. Risk Assessment. Severity of Illness Index. Treatment Outcome

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  • (PMID = 15772795.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Stumpe MR, Chandra RK, Yunus F, Samant S: Incidence and risk factors of bisphosphonate-associated osteonecrosis of the jaws. Head Neck; 2009 Feb;31(2):202-6
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  • BACKGROUND: Intravenous bisphosphonate therapy has been used for treatment of benign and malignant bone diseases and has been linked to osteonecrosis of the jaws.
  • No significant relationship was observed between the incidence of osteonecrosis and demographic parameters, primary tumor, cumulative drug dose, or dosing interval.

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  • (PMID = 18853454.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates
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63. Worsham MJ, Abrams J, Raju U, Kapke A, Lu M, Cheng J, Mott D, Wolman SR: Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population. Breast J; 2007 Mar-Apr;13(2):115-21
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  • [Title] Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population.
  • Women with benign breast diseases (BBD), particularly those with lesions classified as proliferative, have previously been reported to be at increased risk for subsequent development of breast cancer (BC).
  • Ascertainment of subsequent progression to BC from BBD was accomplished through examination of the tumor registries of the Henry Ford Health system, the Detroit SEER registry, and the State of Michigan cancer registry.

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  • (PMID = 17319851.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA070923-05S1; United States / NCI NIH HHS / CA / R01 CA070923-05S2; United States / NCI NIH HHS / CA / R01 CA070923; United States / NCI NIH HHS / CA / R01 CA070923-05; United States / NCI NIH HHS / CA / CA 070923
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS10988; NLM/ PMC1828132
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64. Sraj SA, Lahoud LE, Musharafieh R, Taha A: Nuchal-type fibroma of the ankle: a case report. J Foot Ankle Surg; 2008 Jul-Aug;47(4):332-6
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  • Nuchal-type fibroma is rare benign fibrous tumor that has the potential to recur.
  • It is typically located in the subcutaneous tissues of the posterior aspect of the neck, although it can affect other anatomical sites.

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  • (PMID = 18590898.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Cho KJ, Ro JY, Choi J, Choi SH, Nam SY, Kim SY: Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases. Eur Arch Otorhinolaryngol; 2008 Jul;265 Suppl 1:S47-56
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  • Non-lymphoid mesenchymal neoplasms of salivary gland origin are rare, accounting for 1.9-5% of major salivary gland tumors.
  • Mesenchymal neoplasms accounted for 3.4% of the total of 524 major salivary gland tumors.
  • Thirteen tumors were benign, constituting 3.5% of the total of 371 benign neoplasms.
  • Schwannomas were the most common benign tumors (six cases), followed by lipomas (three cases), plexiform neurofibroma, hemangioma, desmoid tumor, and solitary fibrous tumor (one each).
  • The malignant tumors consisted of one dermatofibrosarcoma protuberans, synovial sarcoma, leiomyosarcoma, pleomorphic liposarcoma and desmoplastic small round cell tumor each.
  • Genetic analysis for fusion transcripts was conclusive in the diagnosis of desmoplastic small round cell tumor, which is extremely rare at this location.
  • Pre-operative imaging study and fine needle aspiration cytology had limitations in prediction of the mesenchymal nature of the tumors, due to either low index of suspicion, similarities to mixed tumors, or specimen inadequacy.
  • Awareness of the development of various mesenchymal tumors in the major salivary glands could increase the accuracy of preoperative and postoperative diagnosis, and therapeutic efficacy.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Infant. Lipoma / diagnosis. Lipoma / pathology. Male. Middle Aged. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Solitary Fibrous Tumors / diagnosis. Solitary Fibrous Tumors / pathology

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  • (PMID = 17934743.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Language] eng
  • [Publication-type] Journal Article
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67. Rubaltelli L, Stramare R, Tregnaghi A, Scagliori E, Cecchelero E, Mannucci M, Gallinaro E, Beltrame V: The role of sonoelastography in the differential diagnosis of neck nodules. J Ultrasound; 2009 Sep;12(3):93-100
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  • [Title] The role of sonoelastography in the differential diagnosis of neck nodules.
  • Ultrasonographic studies of the neck can reveal the nonpalpable thyroid nodules, but the nature of these lesions generally has to be established on the basis of FNAB findings.
  • Indeed, in 5 lymph nodes with sonographic features consistent with malignancy, sonoelastography revealed diffuse elasticity that was indicative of benign disease, which was confirmed by pathological studies.
  • Other nodular lesions of the neck can also be evaluated with sonoelastography, including enlarged parotid glands, but the data in the literature are too limited to allow hypotheses on the role of this imaging modality in this field.
  • Sonoelastography is rapid and simple to perform, and it appears to be a potentially useful tool for the differential diagnosis of neck nodules.
  • Our experience with these lesions indicates that diffuse elasticity is strongly correlated with benign disease.

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  • (PMID = 23396686.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3552973
  • [Keywords] NOTNLM ; Technology assessment / Thyroid / Tumor
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68. Al-Harthy M, Al-Harthy S, Al-Otieschan A, Velagapudi S, Alzahrani AS: Comparison of pheochromocytomas and abdominal and pelvic paragangliomas with head and neck paragangliomas. Endocr Pract; 2009 Apr;15(3):194-202
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  • [Title] Comparison of pheochromocytomas and abdominal and pelvic paragangliomas with head and neck paragangliomas.
  • OBJECTIVE: To compare clinical, radiologic, and pathologic characteristics, as well as management and outcomes, in a series of pheochromocytomas, abdominal and pelvic paragangliomas, and pelvic paragangliomas with head and neck paragangliomas.
  • We searched pathology and medical record databases under the terms pheochromocytoma, paraganglioma, head and neck tumors, carotid body tumors, glomus jugulare, and neuroendocrine tumors.
  • We compared clinical, radiologic, and pathologic characteristics, as well as management and outcomes, between patients with pheochromocytoma, abdominal and pelvic paraganglioma, and head and neck paraganglioma.
  • RESULTS: Eighty-six patients were included (46 with head and neck paraganglioma, 23 with pheochromocytoma, and 17 with abdominal or pelvic paraganglioma).
  • Compared with patients with head and neck paraganglioma, patients with pheochromocytoma or abdominal and pelvic paraganglioma were younger (35.7 +/- 16 years vs 43 +/- 17 years, P = .042) and were more likely to have the classic triad associated with catecholamine hypersecretion of palpitation, excessive sweating, and headache (40% vs 0%, P<.001); hypertension (70% vs 37%, P = .005); and benign tumors (65% vs 43%, P = .03).
  • Patients with head and neck paraganglioma and patients with pheochromocytoma/abdominal and pelvic paraganglioma were not different in female to male ratios (27:19 vs 29:11, respectively, P = .18), tumor size (5.8 +/- 2.7 cm vs 5.7 +/- 3 cm, respectively; P = .85), or remission rate (43% vs 60%, respectively, P = .13).
  • CONCLUSIONS: Head and neck paraganglioma are similar to pheochromocytoma and abdominal and pelvic paraganglioma in size and outcome, but occur at an older age, lack hyperadrenergic manifestations, and are more likely to have local pressure effects and result in persistent disease.
  • [MeSH-major] Abdominal Neoplasms / epidemiology. Adrenal Gland Neoplasms / epidemiology. Head and Neck Neoplasms / epidemiology. Paraganglioma / epidemiology. Pelvic Neoplasms / epidemiology. Pheochromocytoma / epidemiology
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Disease Progression. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Tumor Burden. Young Adult

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  • (PMID = 19364686.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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69. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • Approximately 59 cases of SEF have been reported, with only 12 previously described in head and neck locations.
  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • Histologically, the tumors were well delineated and multinodular, separated by fibrous septae.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Three tumors were graded as 2/3 and two 1/3.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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70. Monfared A, Agrawal S, Jackler RK: Cranial base approaches to inaccessible intracranial tumors. Curr Opin Neurol; 2007 Dec;20(6):726-31
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  • [Title] Cranial base approaches to inaccessible intracranial tumors.
  • PURPOSE OF REVIEW: Craniotomy created through the base of the skull has improved exposure of many types of extraaxial tumors and thus enhanced both tumor control and preservation of neural function.
  • The increasingly documented efficacy of stereotactic radiation for certain tumor types (e.g. meningioma, schwannoma) has permitted nonoperative therapy for some individuals.
  • In large tumors, selective use of less-than-complete microsurgical resection is establishing an increasing role, at times combined with focused radiotherapy of the surgical remnant.
  • The role for transbasal craniotomy is well established in both benign tumors and vascular lesions, but has only limited applicability for high-grade malignant lesions.

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  • (PMID = 17992097.001).
  • [ISSN] 1350-7540
  • [Journal-full-title] Current opinion in neurology
  • [ISO-abbreviation] Curr. Opin. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 55
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71. Sołtys J, Pietniczka-Załeska M, Młyńczyk-Budzynowska K, Majkowski J: [Neoplasms of paranasal sinuses in material of ENT Department MSS Hospital in Warsaw between 2006-2007]. Otolaryngol Pol; 2008;62(4):451-4
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  • Tumors of paranasal sinuses present a small percent of tumors detected in the region of head and neck 3-4% and they present a fraction of a percent of tumors in general /0.16%/.
  • MATERIAL: In the years 2004 and 2005, the National Register of Neoplasms recorded 120 and 132 cases of malignant tumors of paranasal sinuses, respectively.
  • Between 2006-2007 we treated 15 patients with tumors of paranasal sinuses underwent treatment at the ENT department of the MiEdzyleski Szpital Specjalistyczny in Warsaw.
  • The following were analyzed: the advancement stage of the tumor, symptoms, the time that has elapsed from the first appearance until the admission for treatment at the department, the methods of treatment, and the histological differentiation of neoplasms.
  • THE RESULTS: We detected the following:--benign neoplasms: 2 cases of angiofibroma, 3 cases of inverted papilloma;--malignant tumors: 4 cases of Ca planoepitheliale, 1 instance of adenocarcinoma, 1 instance of Ca anaplasticum, 1--melanoma, 1--esthesioneuroblastoma, 1--lymphoma malignum, 1--metastatic tumor.
  • THE CONCLUSIONS: at the moment of the admission for treatment at the ENT department, the advancement stage of tumor T3/T4, from the first signs until the proper diagnosis was that marked with the passage of eight months.
  • Ca planoepitheliale is the most common type of malignant tumors of paranasal sinuses.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Hospitals, Public. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures / methods. Poland. Retrospective Studies. Treatment Outcome

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  • (PMID = 18837222.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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72. Wilkins-Port CE, Ye Q, Mazurkiewicz JE, Higgins PJ: TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1. Cancer Res; 2009 May 1;69(9):4081-91
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  • The phenotypic switching called epithelial-to-mesenchymal transition is frequently associated with epithelial tumor cell progression from a comparatively benign to an aggressive, invasive malignancy.
  • TGF-beta in the tumor microenvironment promotes invasive traits largely through reprogramming gene expression, which paradoxically supports matrix-disruptive as well as stabilizing processes. ras-transformed HaCaT II-4 keratinocytes undergo phenotypic changes typical of epithelial-to-mesenchymal transition, acquire a collagenolytic phenotype, and effectively invade collagen type 1 gels as a consequence of TGF-beta1 + EGF stimulation in a three-dimensional physiologically relevant model system that monitors collagen remodeling.

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  • (PMID = 19383899.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / T32-HL07194; United States / NIGMS NIH HHS / GM / GM57242; United States / NIGMS NIH HHS / GM / GM057242-11; United States / NHLBI NIH HHS / HL / T32 HL007194; United States / NIGMS NIH HHS / GM / R01 GM057242; United States / NIGMS NIH HHS / GM / R01 GM057242-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Plasminogen Activator Inhibitor 1; 0 / SERPINE1 protein, human; 0 / Transforming Growth Factor beta1; 62229-50-9 / Epidermal Growth Factor; EC 3.4.21.7 / Fibrinolysin; EC 3.4.24.22 / Matrix Metalloproteinase 10; EC 3.4.24.7 / Matrix Metalloproteinase 1
  • [Other-IDs] NLM/ NIHMS242077; NLM/ PMC2962982
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73. Boedeker M, Kayser G, Ridder GJ, Boedeker C: [Unusual tumor of the external ear]. Laryngorhinootologie; 2010 Nov;89(11):662-3
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  • [Title] [Unusual tumor of the external ear].
  • [Transliterated title] Ungewöhnlicher Tumor der Ohrmuschel1.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear, External. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Humans. Lymph Nodes / pathology. Male. Neck Dissection. Ultrasonography

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  • (PMID = 20556704.001).
  • [ISSN] 1438-8685
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Davidson T, Goitein O, Avigdor A, Zwas ST, Goshen E: 18F- FDG-PET/CT for the diagnosis of tumor thrombosis. Isr Med Assoc J; 2009 Feb;11(2):69-73
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  • [Title] 18F- FDG-PET/CT for the diagnosis of tumor thrombosis.
  • BACKGROUND: Venous thromboembolism is a well-recognized and relatively frequent complication of malignancy, whereas tumor thrombosis is a rare complication of solid cancers.
  • The correct diagnosis of tumor thrombosis and its differentiation from VTE can alter patient management and prevent unnecessary long-term anticoagulation treatment.
  • OBJECTIVES: To evaluate the contribution of 18F-fluorodeoxyglucose positron emission tomography/computed tomography to the diagnosis of tumor thrombosis and its differentiation from VTE.
  • METHODS: PET/CT scans from 11 patients with suspected tumor thrombosis were retrospectively evaluated.
  • RESULTS: Eight occult tumor thromboses were identified by PET/CT-positive scans.
  • Underlying pathologies included pancreatic, colorectal, renal cell, and head-neck squamous cell carcinoma, as well as lymphoma (4 patients).
  • Accuracy of PET/CT to differentiate between tumor thrombosis and benign VTE was 100% in this small study.
  • It appears that PET/CT may be helpful in the diagnosis of occult tumor thrombosis and its differentiation from VTE.

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  • (PMID = 19432032.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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75. Puttgen KB, Pearl M, Tekes A, Mitchell SE: Update on pediatric extracranial vascular anomalies of the head and neck. Childs Nerv Syst; 2010 Oct;26(10):1417-33
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  • [Title] Update on pediatric extracranial vascular anomalies of the head and neck.
  • Pediatric vascular anomalies can be divided into two broad categories: vascular tumors and vascular malformations.
  • An updated classification was introduced in 1996 by the International Society for the Study of Vascular Anomalies (ISSVA) to include infantile hemangioma variants, other benign vascular tumors, and combined lesions.
  • Widespread confusion propagated throughout the literature and in clinical practice stems from the continued improper use of many of the terms used to describe vascular tumors and malformations ignoring their pathophysiology.
  • The clinical presentation usually identifies what general type of vascular anomaly is present, either vascular tumor or vascular malformation.
  • CONCLUSIONS: Adoption and use of uniform nomenclature in the ISSVA classification system is the first vital step in correct diagnosis and treatment of often complicated vascular tumors and vascular malformations.
  • [MeSH-major] Arteriovenous Malformations / diagnostic imaging. Arteriovenous Malformations / pathology. Head / blood supply. Neck / blood supply. Vascular Neoplasms / diagnostic imaging. Vascular Neoplasms / pathology

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  • (PMID = 20697721.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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76. Shimada K, Sakamoto Y, Esaki M, Kosuge T, Hiraoka N: Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body. Dig Surg; 2008;25(1):46-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body.
  • BACKGROUND/AIM: Medial pancreatectomy has been applied as a safe and effective alternative in benign diseases located in the pancreatic neck or body.
  • Three patients with islet cell tumor and 1 patient with solid pseudopapillary tumor had no malignant disease.
  • CONCLUSIONS: A medial pancreatectomy is a safe and effective alternative for the treatment of intraductal papillary mucinous neoplasm, islet cell tumor, or solid pseudopapillary tumor located in the neck or body of the pancreas.

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  • (PMID = 18292661.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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77. Rodrigo JP, Rinaldo A, Devaney KO, Shaha AR, Ferlito A: Molecular diagnostic methods in the diagnosis and follow-up of well-differentiated thyroid carcinoma. Head Neck; 2006 Nov;28(11):1032-9
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  • Preliminary investigations have suggested that molecular diagnostic assays using tumor-specific markers may improve the sensitivity and accuracy of FNA and so may be expected to reduce the frequency of open surgical procedures by identifying those patients with demonstrably benign lesions who do not require definitive surgical excision of their lesions for diagnosis.
  • At the same time, thyroid-specific mRNA assays (especially thyroglobulin mRNA testing) have been used by investigators in the postoperative follow-up of patients with thyroid cancer as a potential means of detecting tumor recurrence in the peripheral blood.
  • [MeSH-major] Biomarkers, Tumor. Molecular Diagnostic Techniques. Thyroid Neoplasms / diagnosis

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  • (PMID = 16732600.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44v6 antigen; 0 / Fibronectins; 0 / Galectin 3; 0 / Glycoproteins; 0 / HBME-1 antigen; 0 / Membrane Proteins; 0 / oncofetal fibronectin; 124544-67-8 / HMGA1a Protein; 9010-34-8 / Thyroglobulin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 2.7.7.49 / Telomerase
  • [Number-of-references] 80
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78. Noonan VL, Greene DJ, Brodsky G, Kabani SP: Extraneural sclerosing perineurioma of the buccal mucosa: a case report and clinicopathologic review. Head Neck Pathol; 2010 Jun;4(2):169-73
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  • The perineurioma is an infrequently encountered benign peripheral nerve sheath tumor composed of a clonal proliferation of perineurial cells.
  • Histopathologically, the tumor is composed of a well circumscribed nodular proliferation of spindle cells arranged in a storiform growth pattern, in some areas subtly arranged around vascular channels.
  • The tumor cells reveal positive immunostaining for epithelial membrane antigen (EMA), collagen type IV and vimentin, and negative immunostaining for S-100 protein, consistent with a perineurial origin.
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Collagen Type IV / metabolism. Humans. Male. Mucin-1 / metabolism. Treatment Outcome. Vimentin / metabolism

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  • (PMID = 20364337.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type IV; 0 / Mucin-1; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2878626
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79. Takahama A Jr, León JE, de Almeida OP, Kowalski LP: Nonlymphoid mesenchymal tumors of the parotid gland. Oral Oncol; 2008 Oct;44(10):970-4
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  • [Title] Nonlymphoid mesenchymal tumors of the parotid gland.
  • Salivary gland tumors are uncommon and most of them are of epithelial origin.
  • Mesenchymal tumors affecting the parotid are extremely rare, and we present a series of 19 cases.
  • All parotid tumors (600 cases) treated at the Department of Head and Neck Surgery from A.C.
  • 15 out of 19 were benign tumors, including 5 lymphangiomas, 5 neurofibromas, and one case each of schwannoma, lipoma, solitary fibrous tumor, meningioma and giant cell tumor.
  • Four malignant tumors were classified as rhabdomyosarcoma, fibrosarcoma, Langerhans cell histiocytosis and endodermal sinus tumor.
  • From the malignant cases, only the patient with fibrosarcoma died due the tumor, the other three are alive with no signs of recurrence.
  • In our series of 600 cases of parotid gland tumors, nonlymphoid mesenchymal tumors corresponded to 3.16% (19 cases; 15 benign and 4 malignant).
  • [MeSH-minor] Adolescent. Adult. Aged. Brazil. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Female. Fibrosarcoma / pathology. Histiocytosis, Langerhans-Cell / pathology. Humans. Infant. Male. Middle Aged. Neurofibroma / pathology. Rhabdomyosarcoma / pathology. Young Adult

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  • (PMID = 18282791.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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80. Skrivan J, Zvĕrina E, Kluh J, Chovanec M, Pádr R: Our experience with surgical treatment of tympanojugular pragangliomas. Prague Med Rep; 2010;111(1):25-34
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  • Tympanojugular paragangliomas are benign and slow growing lesions of the lateral skull base.
  • Treatment modalities include preoperative embolization of feeding vessels and tumour itself, surgical removal and irradiation.
  • Surgical radicality has been achieved in 62.5%, in the rest of patients the tumour remnants were either irradiated with a Leksell gamma knife, or left without treatment in a wait-end-rescan approach.
  • According to the benign character of the tumour, radicality is not always the highest goal, since a radical removal may be compromised by a high postoperative morbidity.
  • [MeSH-major] Ear Neoplasms / surgery. Glomus Jugulare Tumor / surgery. Paraganglioma, Extra-Adrenal / surgery

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  • (PMID = 20359435.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
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81. Arias-Santiago S, Aceituno-Madera P, Aneiros-Fernández J, Gutiérrez-Salmerón MT, Naranjo-Sintes R: Syringocystoadenoma papilliferum associated with apocrine hidrocystoma and verruca. Dermatol Online J; 2009;15(11):9
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  • Syringocystoadenoma papilliferum is a benign adnexal tumor usually located in head and neck that occurs during childhood or adolescence.
  • It is unusual to see the occurrence of three histopathologic types of tumors coexisting in one cutaneous lesion.
  • [MeSH-minor] Biopsy, Needle. Cystadenoma / complications. Cystadenoma / pathology. Cystadenoma / surgery. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Thoracic Wall. Treatment Outcome. Young Adult

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  • (PMID = 19951645.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. O'Callaghan MG, House M, Ebay S, Bhadelia R: Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. J Comput Assist Tomogr; 2005 Jan-Feb;29(1):130-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging.
  • A case of fetal rhabdomyoma (myxoid type) of the head and neck demonstrated on prenatal magnetic resonance imaging (MRI) is presented.
  • This benign tumor of skeletal muscle is uncommon and should not be confused with its malignant counterpart-rhabdomyosarcoma.
  • With the increasing use of ultrafast MRI, the radiologist is more likely to encounter head and neck masses in the fetus.
  • [MeSH-major] Fetal Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Magnetic Resonance Imaging. Prenatal Diagnosis. Rhabdomyoma / diagnosis
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Gestational Age. Humans. Infant, Newborn. Neoplasm Recurrence, Local / pathology. Pregnancy. Ultrasonography, Prenatal


83. Nakai N, Takenaka H, Kishimoto S: Atypical fibroxanthoma on a bald scalp. J Dermatol; 2005 Oct;32(10):848-51
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  • The AFX was completely resected, and the patient has not had tumor recurrence or metastasis for over four postoperative years.
  • This case therefore provides further support to the theory that AFX displays a clinically benign course, even though it is essentially a malignant tumor histologically located in the dermis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Scalp Dermatoses / pathology
  • [MeSH-minor] Aged, 80 and over. Alopecia / complications. Head and Neck Neoplasms / complications. Head and Neck Neoplasms / pathology. Humans. Male. Scalp. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 16361741.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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84. Shekar TY, Gole G, Prabhala S, Gole S: Plexiform neurofibroma: a rare tumor of submandibular salivary gland. J Surg Tech Case Rep; 2010 Jul;2(2):81-3
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  • [Title] Plexiform neurofibroma: a rare tumor of submandibular salivary gland.
  • Excised mass was reported histopathologically as plexiform neurofibroma of submandibular salivary gland.Plexiform neurofibroma of the salivary gland is a rare benign tumor often present in the parotid gland.
  • It is a slow growing, locally infiltrating tumor.

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  • (PMID = 22091342.001).
  • [ISSN] 0976-2825
  • [Journal-full-title] Journal of surgical technique and case report
  • [ISO-abbreviation] J Surg Tech Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3214285
  • [Keywords] NOTNLM ; Plexiform neurofibroma / sialadenitis / sialolithiasis / submandibular salivary gland
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85. Woźniak AW, Nowaczyk MT, Osmola K, Golusinski W: Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):845-9
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  • Benign osteoblastoma is a rarely seen tumor of the facial bones.
  • The authors present a case of a 30-year-old man with a tumor of the mandibular body and ramus.
  • A second recurrence occured in the pharyngo-glossal region and this time the tumor was histologically diagnosed as an osteoblastoma, but with foci of well-differentiated osteosarcoma.
  • While osteoblastomas are rare, and their sarcomatous change even rarer, our experience with this case lead us to suggest that a therapeutic preventative approach, involving both chemotherapy and total excision of the tumor, is the regime to adopt with osteoblastomas which involve soft tissues and have radiological features suggesting malignancy.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Osteoblastoma / pathology. Osteosarcoma / pathology

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  • (PMID = 20012077.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
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86. Hosseini SM, Borghei P, Borghei SH, Ashtiani MT, Shirkhoda A: Angiofibroma: an outcome review of conventional surgical approaches. Eur Arch Otorhinolaryngol; 2005 Oct;262(10):807-12
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor of the nasopharynx, and for its treatment, many surgical approaches have been recommended.
  • However, selecting the appropriate one for the tumor in an advanced stage is still controversial.
  • Involvement of the orbit, middle cranial fossa and base of the pterygoid by the primary JNA results in a higher incident of recurrent tumor.
  • Among different surgical techniques, the lowest recurrence rate is seen either in the transpalatal approach when the tumor is limited to the nasopharynx with extension to the nasal cavity or paranasal sinuses or with the Lefort I approach when skull base invasion is present.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery. Neoplasm Recurrence, Local / epidemiology. Otorhinolaryngologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Child. Disease-Free Survival. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15739087.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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87. Schaller B: Spinal meningioma: relationship between histological subtypes and surgical outcome? J Neurooncol; 2005 Nov;75(2):157-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraspinal meningiomas are slow growing benign tumors that produce indolent neurological deficits, which are often reversible following operation.
  • Tumor position was laterally in 19 (58%), posteriorly in 8 (24%) and anteriorly in 6 (18%) patients.
  • Following tumor resection, neurological deficits resolved in 26 of 33 patients (79%) and worsened in 7 of 33 patients (21%) all of the latter had meningiomas of the psammomatous type.
  • Posterior or lateral tumor position in the spinal canal, location below C4, age less than 60 years, and duration of preoperative symptoms seem to be correlated with a good outcome.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Angiography. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Myelography. Neoplasm Recurrence, Local. Neurologic Examination. Prognosis. Regression Analysis. Retrospective Studies. Sex Factors. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Tumor Burden. X-Rays

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  • (PMID = 16132511.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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88. Saleh H, Kapadia R: Aspiration biopsy cytology of extraabdominal desmoid tumor concurrently occurring in a patient with tumoral calcinosis. Diagn Cytopathol; 2008 Sep;36(9):624-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aspiration biopsy cytology of extraabdominal desmoid tumor concurrently occurring in a patient with tumoral calcinosis.
  • Extraabdominal fibromatosis or desmoid tumor (DT) is a slow growing locally aggressive soft tissue tumor that can occur anywhere in the body.
  • We report the aspiration biopsy cytology features of a case of DT of the right neck area in a 35-year-old man who had a long standing history of tumoral calcinosis.
  • The aspirate was interpreted as "benign spindle cell lesion" and confirmed as DT on histologic examination of the resected mass.
  • We discuss the possible differential diagnoses of other benign or malignant lesions on fine-needle aspiration (FNA) biopsy and especially discuss the aspiration cytology features of DT compared with those of tumoral calcinosis.

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  • (PMID = 18677759.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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89. Caloglu M, Yurut-Caloglu V, Altaner S, Huseyinova G, Unlu E, Karagol H, Uzal C: Oncocytic carcinoma of the parotid gland. Onkologie; 2006 Sep;29(8-9):388-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Oncocytic carcinoma is a rare tumor of major salivary glands.
  • Despite being described 5 decades ago, not much is known about these rare tumors.
  • Histochemical or electron microscopic confirmation of the oncocytic nature of the tumor cell is needed for differential diagnosis.
  • CASE REPORT: A 58-year old man presented with a recurrent mass in the left parotid gland with a prior diagnosis of monomorphic adenoma in the same localization which had been treated by tumor excision in July 2002.
  • Left superficial parotidectomy followed by radiotherapy into tumor bed and upper neck were carried out in September 2004.
  • CONCLUSION: For an accurate approach in the management of patients, oncocytic adenocarcinoma should be considered in the differential diagnosis of lesions of the parotid gland, most of which are benign.

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  • (PMID = 16974117.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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90. Mahalingam M, Alter JN, Bhawan J: Multiple cellular neurothekeomas--a case report and review on the role of immunohistochemistry as a histologic adjunct. J Cutan Pathol; 2006 Jan;33(1):51-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cellular neurothekeoma is a relatively rare, benign cutaneous neoplasm, which usually presents as a solitary papule or nodule involving the head and neck area of young adults.
  • METHODS: We report a 30-year-old, otherwise healthy, male who presented with multiple neurothekeomas (15) in the head and neck area over a period of 12 years.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 16441413.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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91. Cincik H, Gungor A, Ertugrul E, Cekin E, Dogru S: Peripheral osteoma of the mandible mimicking a parotid mass. Eur Arch Otorhinolaryngol; 2007 Apr;264(4):429-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the case of a peripheral osteoma mimicking a benign tumor in the left parotid gland of a 75-year-old woman.
  • The clinical presentation of the painless mass on the lateral surface of the mandibular ascending ramus was suggestive of a benign parotid tumor such as a pleomorphic adenoma.

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  • (PMID = 17091281.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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92. Mouton WG, Kienle Y, Muggli B, Naef M, Wagner HE: Tumors associated with superficial thrombophlebitis. Vasa; 2009 May;38(2):167-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumors associated with superficial thrombophlebitis.
  • BACKGROUND: To assess the incidence of malignant tumors in patients with thrombophlebitis of the leg with regard to potential early tumor detection.
  • RESULTS: There were 18 patients (12.9%) suffering from thrombophlebitis in association with a malignant tumor: breast cancer in seven patients, colon carcinoma and haematologic cancer in four, skin cancer in three patients and one case each of oesophageal, prostatic, kidney and neck cancer .
  • Superficial thrombophlebitis may have been associated in four cases (2.9%) with a benign tumor.

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  • (PMID = 19588305.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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93. Kabukcuoglu F, Kabukcuoglu Y, Tanik C, Sakiz D, Karsidag S: Breast carcinoma metastasis in recurrent myxoid liposarcoma. Pathol Oncol Res; 2009 Sep;15(3):467-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor.
  • The tumor recurred twice and was reexcised.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Radiotherapy


94. Coutinho-Camillo CM, Brentani MM, Nagai MA: Genetic alterations in juvenile nasopharyngeal angiofibromas. Head Neck; 2008 Mar;30(3):390-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors.
  • Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension.
  • Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial.
  • Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor.

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18228521.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / beta Catenin; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 103
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96. Asadi Amoli F, Sina AH, Kasai A, Ayan Z: A well-known lesion in an unusual location: infantile myofibroma of the eyelid: a case report and review of literature. Acta Med Iran; 2010 Nov-Dec;48(6):412-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Myofibroma is a neoplasia of myofibroblasts that can be solitary or multiple and it is found most commonly in the head & neck region including scalp, forehead, parotid region and oral cavity.
  • It has a benign course in the solitary form and fatal in its multiple form.
  • Its pattern of growth and architecture rules out the other differential diagnoses like nodular fasciitis, fibrous histiocytoma, infantile fibromatosis, and peripheral primitive neuroectodermal tumor, mesenchymal chondrosarcoma, malignant hemangiopericytoma, juvenile fibrosarcoma and poorly differentiated synovial sarcoma.

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  • (PMID = 21287484.001).
  • [ISSN] 1735-9694
  • [Journal-full-title] Acta medica Iranica
  • [ISO-abbreviation] Acta Med Iran
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Iran
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97. Pabiszczak M, Wierzbicka M: [Difficulty in diagnostic procedure in the malignant fibrous histiocytomas of larynx]. Otolaryngol Pol; 2008;62(5):613-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pathologic and immunohistochemical evaluation revealed tumor a few months after first symptoms.
  • There was unilateral metastases into the neck lymph nodes.
  • Wide, aggressive excision of the tumour with total larygectomy to be the treatment of choice because it was difficult to prove clinically and pathologically that it was MFH.
  • Unilateral neck dissection was done due to metastases into the neck lymph nodes.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / secondary. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Humans. Laryngectomy. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Radiotherapy, Adjuvant. Remission Induction

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  • (PMID = 19004268.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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98. Guevara N, Lassalle S, Castillo L, Butori C, Santini J: [Angiomyolipoma of the parotid gland]. Ann Otolaryngol Chir Cervicofac; 2008 Apr;125(2):90-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Angiomyolipoma is a rare benign mesenchymal tumor.
  • Only a few cases have been described in the head and neck region and these are usually not associated with tuberous sclerosis or lymphangioléiomyomatosis.
  • Partial parotidectomy was performed and the tumor showed the characteristic appearance of angiomyolipoma, with an admixture of fat smooth cells and tortuous thick-walled blood vessels.
  • CONCLUSION: This article discusses the presentation and management associated with this exceptional tumor.

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  • (PMID = 18280455.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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99. Adams DM, Lucky AW: Cervicofacial vascular anomalies. I. Hemangiomas and other benign vascular tumors. Semin Pediatr Surg; 2006 May;15(2):124-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervicofacial vascular anomalies. I. Hemangiomas and other benign vascular tumors.
  • Scientific advances over the past two decades have, however, led to international consensus among experts on a system of disease classification that comprises vascular tumors and vascular malformations.
  • The most common vascular tumor is hemangioma, which is frequently seen in the head and neck area.
  • This article presents an overview of hemangiomas and other vascular tumors, highlighting cervicofacial lesions and describing critical and underappreciated clinical presentations.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy. Hemangioma / diagnosis. Hemangioma / therapy

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  • (PMID = 16616316.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine; 9008-11-1 / Interferons
  • [Number-of-references] 33
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100. Linkov F, Stack B, Yurkovetsky Z, Poveda S, Lokshin A, Ferris RL: Head and neck squamous and thyroid carcinomas: multiplexed Luminex approaches for early detection. Expert Opin Med Diagn; 2007 Sep;1(1):129-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Head and neck squamous and thyroid carcinomas: multiplexed Luminex approaches for early detection.
  • Head and neck cancer (HNC) comprises a broad group of malignancies affecting a number of organs in this anatomical region.
  • The most common histologic type is mucosal squamous cell carcinoma of the head and neck (SCCHN).
  • Although thyroid cancer has a generally favorable long-term outcome, its screening and diagnosis pose a challenge due to the prevalence of benign nodular thyroid disease, the rising incidence of thyroid cancer, chronicity and recurrence.
  • In the authors' published studies, it was hypothesized that an expanded panel of biomarkers comprised of cytokines, chemokines, growth factors and other tumor markers, which individually may show some promising correlation with disease status, might provide higher diagnostic power if used in combination.
  • The potential clinical role for using these technologies in follow-up, tumor surveillance to permit early identification of recurrence of SCCHN or thyroid cancer in recurrent disease or second primary tumors is discussed.

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  • (PMID = 23489275.001).
  • [ISSN] 1753-0059
  • [Journal-full-title] Expert opinion on medical diagnostics
  • [ISO-abbreviation] Expert Opin Med Diagn
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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