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1. Dabholkar JP, Vora K, Vaidya A, Sharma A: Benign jaw tumors. Indian J Otolaryngol Head Neck Surg; 2009 Sep;61(3):240-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign jaw tumors.
  • The jaw bones may develop the same types of tumors as the other bones of the body but may also develop tumors arising from the alveolar processes (epulis) and the developing teeth (odontomes).
  • They are usually benign in nature and can affect the functions of mastication, swallowing and cause facial deformity.
  • They make about 3% of all bone tumors with a tendency for a local recurrence if a wide excision is not contemplated at the first attempt.
  • Local destruction caused by the tumor can mimic a malignancy; however with imaging we can get a fair idea about the treatment planning.

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  • [Cites] Folia Med Cracov. 1998;39(1-2):35-141 [10481376.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Feb;99(2):191-5 [15660091.001]
  • [Cites] Br J Oral Maxillofac Surg. 2006 Oct;44(5):386-8 [16182417.001]
  • (PMID = 23120644.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3449977
  • [Keywords] NOTNLM ; Ameloblastoma / Dentigerous cyst / Jaw tumors / Odontomes / Osteoblastoma
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2. Schneider AB, Ron E, Lubin J, Stovall M, Shore-Freedman E, Tolentino J, Collins BJ: Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck. Neuro Oncol; 2008 Feb;10(1):73-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck.
  • Childhood radiation exposure has been associated with an increased risk for developing several neoplasms, particularly benign and malignant thyroid tumors, but little is known about the risk of developing acoustic neuromas.
  • Forty-three patients developed benign acoustic neuromas, forty of them surgically resected, far in excess of what might be expected from data derived from brain tumor registries.
  • Although acoustic neuromas are usually benign and often asymptomatic, many cause significant morbidity.
  • Any symptoms of an acoustic neuroma in a patient with a history of radiation to the head and neck area should be investigated carefully, and the threshold for employing imaging should be lowered.

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  • (PMID = 18079359.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-21518; United States / NCI NIH HHS / CP / N01-CP-85604; United States / NCI NIH HHS / CP / N01-CP-95614; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2600840
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3. Kulkarni N, Andrews SJ, Rao V, Rajagopal KV: Case report: Benign porta hepatic schwannoma. Indian J Radiol Imaging; 2009 Jul-Sep;19(3):213-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report: Benign porta hepatic schwannoma.
  • Schwannoma is a myelin sheath tumor that can occur almost anywhere in the body.
  • The most common locations are the central nervous system, extremities, neck, mediastinum and retroperitoneum.
  • Benign schwannomas in the porta hepatis are extremely rare and radiologically are diagnosed as either enlarged lymph nodes or bowel masses, such as gastrointestinal stromal tumors.

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  • (PMID = 19881089.001).
  • [ISSN] 1998-3808
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2766878
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4. Stepanova A, Marsch WC, Stadie V: [A rare low-grade malignant scalp tumor. Atypical fibroxanthoma]. Hautarzt; 2005 Jul;56(7):679-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare low-grade malignant scalp tumor. Atypical fibroxanthoma].
  • [Transliterated title] Seltener niedrig-maligner Tumor der Kopfhaut. Atypisches Fibroxanthom.
  • A 79-year-old patient presented with an asymptomatic scalp tumor which had grown over the past 9 months.
  • AFX is a rare tumor, but important in the differential diagnosis of other scalp tumors.
  • AFX is a low-grade malignant tumor and most cases behave in a benign fashion.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 15726303.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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5. Deutsch J, Trick D, Delank KW: [Giant scalp mass]. HNO; 2010 Dec;58(12):1204-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Monströser Tumor der Kopfhaut.
  • A 55-year-old man was referred to our department with bleeding from a painless tumor located at the left parietal region of the head which had been progressively growing for a period of 2 years.
  • The partly livid and ulcerated surface of the tumor was interspersed with light-yellow chalky material.
  • Pilomatricoma is a rare, benign skin neoplasm that originates from hair matrix cells and is most frequently located in the head and neck region.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • (PMID = 20577705.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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6. Bae CH, Kim YD, Song SY: Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus. Clin Exp Otorhinolaryngol; 2010 Sep;3(3):172-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus.
  • A benign pleomorphic adenoma is the most common tumor of the salivary glands.
  • This tumor has the potential to metastasize to bone, the head and neck region, visceral organs and skin.
  • Although there a few reports about a benign pleomorphic adenoma metastasizing to the maxillary sinus in the paranasal sinuses, there are no reports about a metastatic benign pleomorphic adenoma in the sphenoid sinus.
  • We report here on a case of a benign pleomorphic adenoma of the soft palate that metastasized to the sphenoid sinus, and we briefly review the relevant clinical literature.

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  • (PMID = 20978542.001).
  • [ISSN] 2005-0720
  • [Journal-full-title] Clinical and experimental otorhinolaryngology
  • [ISO-abbreviation] Clin Exp Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2958505
  • [Keywords] NOTNLM ; Metastasis / Pleomorphic adenoma / Sphenoid sinus
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7. Grasmuck EA, Nelson BL: Keratocystic odontogenic tumor. Head Neck Pathol; 2010 Mar;4(1):94-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Keratocystic odontogenic tumor.
  • The keratocystic odontogenic tumor is a benign developmental tumor with many distinguishing clinical and histologic features.
  • [MeSH-major] Maxillary Neoplasms / pathology. Odontogenic Cysts / pathology. Odontogenic Tumors / pathology

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  • (PMID = 20237995.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2825523
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8. Grandi F, Colodel MM, Monteiro LN, Leão JR, Rocha NS: Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment. BMC Vet Res; 2010;6:45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment.
  • Mammary EMH is a rare condition either in human and veterinary medicine and can be associated with benign mixed mammary tumors, similarly to that described in this case.
  • CASE PRESENTATION: Hematopoietic stem cells were found in a benign mixed mammary tumor of a 7-year-old female mongrel dog that presents a nodule in the left inguinal mammary gland.
  • Histological examination confirmed the presence of an active hematopoietic bone marrow within the bone tissue of a benign mammary mixed tumor.
  • CONCLUSIONS: EMH is a rare condition described in veterinary medicine that can be associated with mammary mixed tumors.
  • It's detection can be associated with several neoplastic and non-neoplastic mammary lesions, i.e. osteosarcomas, mixed tumors and bone metaplasia.

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  • (PMID = 20846427.001).
  • [ISSN] 1746-6148
  • [Journal-full-title] BMC veterinary research
  • [ISO-abbreviation] BMC Vet. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hemoglobins
  • [Other-IDs] NLM/ PMC2954924
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9. Kang CM, Choi SH, Hwang HK, Kim DH, Yoon CI, Lee WJ: Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas. J Laparoendosc Adv Surg Tech A; 2010 Sep;20(7):581-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas.
  • Laparoscopic DP, with its division at the pancreatic neck (subtotal pancreatectomy [STP]), is more challenging because there are major vascular structures, such as the celiac axis, coronary vein, and superior mesenteric vein-splenic vein-portal vein (SMV-SV-PV) confluence around the pancreatic neck portion to be dissected.
  • PATIENTS AND METHODS: Ten patients underwent laparoscopic STP with pancreatic division at the level of SMV-SV-PV confluence for benign and borderline pancreatic disease.
  • All patients had benign or borderline malignant tumors in the body near the neck of the pancreas, with a median tumor size of 3 cm (range, 1-9.2).
  • Compared with open DP with the division of the pancreatic neck, a more frequent rate of spleen preservation (P = 0.004), longer operation time (P = 0.006), and early postoperative recovery presented by early intake of a soft diet (P = 0.001) and earlier discharge (P = 0.03) were significantly more frequent in the laparoscopic STP group.
  • CONCLUSIONS: Laparoscopic DP with division of the pancreatic neck is considered feasible and safe.

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  • (PMID = 20629517.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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10. Wang CP, Chang YL, Ko JY, Cheng CH, Yeh CF, Lou PJ: Desmoid tumor of the head and neck. Head Neck; 2006 Nov;28(11):1008-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor of the head and neck.
  • BACKGROUND: [corrected] Desmoid tumors are rare benign tumors but have a tendency toward local recurrence after resection because of their infiltrative growth and frequent entrapment of vital structures in the head and neck region.
  • We report 24 desmoid tumors of the head and neck and propose a reasonable approach in the management of such cases.
  • METHODS: Twenty-four patients (9 male and 15 female; median age, 33 years; range, 0-66 years) with a desmoid tumor of the head and neck (neck, 15 patients; head, 9 patients) treated from 1990 to 2004 were retrospectively analyzed.
  • In the neck, 8 tumors were around the superficial layer of deep cervical fascia, whereas 4 tumors of the neck involved the prevertebral fascia and 2 involved brachial plexus.
  • RESULTS: Twenty patients received complete resection of the tumor, but the section margin was positive in 8 patients, of which 6 patients remained free of disease in a period of 13 to 105 months.
  • Two patients underwent partial resection of the tumor because of brachial plexus involvement.
  • The hypopharygneal tumor in a newborn had spontaneously complete regression, and tracheostomy was closed at the age of 6 years.
  • One patient remained with stable disease for 14 months after biopsy of the tumor without excision.
  • Surgical resection of the tumor with close observation is suggested even if the section margin is positive.
  • If a desmoid tumor cannot be removed grossly, regression or arrested growth of the remaining tumor is expected.
  • Radiotherapy might be reserved for a growing tumor.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Head and Neck Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 16983695.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Domfeh AB, Fichera M, Hunt JL: Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck. Arch Pathol Lab Med; 2006 Aug;130(8):1184-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck.
  • CONTEXT: Angiosarcomas are rare malignancies that commonly arise in the head and neck.
  • OBJECTIVE: This study compared the molecular profile of angiosarcoma with that in some benign vascular lesions.
  • This supports the cell culture-based theories that tumorigenesis in endothelial cells likely involves these chromosomes and provides some insight into the potential pathogenesis of angiosarcomas and benign hemangiomas.
  • [MeSH-major] Genes, Tumor Suppressor. Head and Neck Neoplasms / genetics. Hemangioma / genetics. Hemangiosarcoma / genetics. Loss of Heterozygosity / genetics
  • [MeSH-minor] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 13. Chromosomes, Human, Pair 17. DNA, Neoplasm / analysis. Endothelium, Vascular / pathology. Genes, Retinoblastoma. Genes, Wilms Tumor. Genes, p53. Genetic Markers. Granulation Tissue / pathology. Humans. Microdissection. Microsatellite Repeats / genetics

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  • (PMID = 16879020.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Genetic Markers
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12. Zhou J, Dong M, Kong F, Li Y, Tian Y: Central pancreatectomy for benign tumors of the neck and body of the pancreas: report of eight cases. J Surg Oncol; 2009 Sep 1;100(3):273-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Central pancreatectomy for benign tumors of the neck and body of the pancreas: report of eight cases.
  • BACKGROUND: To discuss the advantage of central pancreatectomy in the patients with benign tumors of the neck and body of the pancreas.
  • The operation is carried out by exposition of the pancreatic neck and body involved by the lesion.
  • RESULTS: Central pancreatectomy was done in eight patients including five mucinous cystadenomas, one serious cystadenoma, one insulinoma and one nonfunctional islet cell tumor.
  • CONCLUSION: Central pancreatectomy is a safe technique for benign tumors of the pancreatic neck and body, especially when the enucleation is very difficult.

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  • (PMID = 19267362.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Jokinen CH, Wolgamot GM, Argenyi ZB: Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin. J Cutan Pathol; 2008 Feb;35(2):215-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin.
  • Schwannoma and neurofibroma account for the majority of cutaneous benign peripheral nerve sheath tumors and usually pose little diagnostic difficulty in their classic forms.
  • In rare instances, however, benign peripheral nerve sheath tumors may display epithelioid morphology and lack otherwise usual features of schwannoma or neurofibroma, making classification difficult.
  • These unusual changes may prompt consideration of other benign neoplasms or a malignancy.
  • Benign epithelioid peripheral nerve sheath tumor (BEPNST) is a somewhat non-specific term recently proposed to describe these neoplasms of imprecise histogenesis.
  • Specifically, the neoplastic cells in this tumor were nearly obscured by the collagen, which formed large nodules and compressed the majority of the few remaining tumor cells to the periphery of the lesion.
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Neck / pathology

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  • (PMID = 18190449.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9007-34-5 / Collagen
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14. Kanazawa T, Ohta Y, Goutsu K, Takeoda K, Tsubaki K, Kodama K, Inoue R, Usubuchi H, Iino Y: [Significant factors affecting the operation time for benign parotid tumor]. Nihon Jibiinkoka Gakkai Kaiho; 2008 Jun;111(6):481-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Significant factors affecting the operation time for benign parotid tumor].
  • Tumors of the parotid gland are fairly frequent among head and neck tumors.
  • Parotidectomy for benign tumors is necessary for diagnosis and therapy.
  • To measure the operation time and determine the factors affecting it, 71 cases, including 43 cases of pleomorphic adenomas and 28 cases Warthin's tumor, were retrospectively reviewed to the determine if the operation time depended on the age, sex, operated side, presence of complications, BMI, bleeding volume, tumor size, tumor location, exposure of branches of the facial nerve, and experience of the surgeon.
  • The results revealed that the bleeding volume, tumor size, tumor location and experience of the surgeon were significantly correlated with the operation time, whereas age, sex, operated side, presentation of complications and BMI showed no correlation with the operation time.
  • Taken together, to shorten the operation time, the inexperienced surgeon should start with smaller tumors and surgery in the superficial lobe in the initial training period, and supervision by well-experienced supervised surgeons is required until 30-40 are undertaken.

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  • (PMID = 18634454.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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15. Wei BJ, Zhu XL, Chen YL, Shen H, Peng PH, Ge F, Tian Y, Liu B, Shi XZ, Wang XW: [Surgical management of tumor in the conjunctive area among neck, thorax and axilla]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Sep;42(9):679-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical management of tumor in the conjunctive area among neck, thorax and axilla].
  • OBJECTIVE: To study the surgical management of tumors in the conjunctive area among the neck, thorax and axilla and its efficacy.
  • 1999 to March 2006, eleven cases with benign tumors in the area between the neck, thorax and axilla were collected and analysed.
  • CT scans showed that the neck, thorax and axilla were affected simultaneously more or less.
  • After the disarticulation and displacement of the clavicle, the tumor was removed with the structures of importance in the neck, thorax and axilla under direct views.
  • RESULTS: All these tumors were completely removed, injury of vertebral artery was encounter in two cases, and immediate repair was successfully carried out.
  • CONCLUSIONS: Benign tumors in the area between neck, thorax and axilla could be successfully dissected and removed with displacement of the medial portion of the clavicle.
  • [MeSH-major] Axilla / surgery. Head and Neck Neoplasms / surgery. Thoracic Neoplasms / surgery

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  • (PMID = 18051568.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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16. Gibson MK, Kies M, Kim S, Savvides P, Kotsakis A, Blumenschein G, Worden F, Chen H, Grandis J, Argiris A: Cetuximab (C) and bevacizumab (B) in patients with recurrent or metastatic head and neck squamous cell carcinoma: An updated report. J Clin Oncol; 2009 May 20;27(15_suppl):6049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cetuximab (C) and bevacizumab (B) in patients with recurrent or metastatic head and neck squamous cell carcinoma: An updated report.
  • Upregulation of VEGF has been associated with C resistance, thus, combined targeting may enhance anti-tumor activity.
  • Specific biomarkers relating to EGFR and VEGFR signaling will be evaluated in tumor tissues and blood samples.
  • Grade (G) 3 adverse events included: hemorrhage (from a benign neck ulcer), 1; hypertension, 2; infection, 2; rash, 2; dysphagia, 4; hypophosphatemia, 1; and fatigue, 1.

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  • (PMID = 27961925.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Rego A, Amado J, Esteves I, Almeida J, Furtado A, Couceiro A, Moura e Sá J: [Endobronchial granular cell tumor - what approach to take]. Rev Port Pneumol; 2006 Jul-Aug;12(4):463-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endobronchial granular cell tumor - what approach to take].
  • [Transliterated title] Tumor de células granulares endobrônquico - Como abordamos?
  • Granular cell tumor is a mesenchymal neoplasm almost always benign, with tendency to recurrence.
  • Although it is more frequent in in the head and neck it has been described in almost all areas of the body.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / therapy. Granular Cell Tumor / diagnosis. Granular Cell Tumor / therapy

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  • (PMID = 16969575.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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18. Yang YS, Wang XD, Ji DG, Zhang D, Xie YJ, Meng ZH, Zhang XW: [Middle segment pancreatectomy for the benign tumors of the neck and body of the pancreas (report of 15 cases)]. Zhonghua Wai Ke Za Zhi; 2010 Sep 15;48(18):1402-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Middle segment pancreatectomy for the benign tumors of the neck and body of the pancreas (report of 15 cases)].
  • OBJECTIVE: To study the clinical application value of middle segment pancreatectomy in the treatment of benign tumors of the amphi-neck of the pancreas.
  • They all received middle segment pancreatectomy for benign tumors of the amphi-neck of the pancreas.
  • Postoperative pathology showed that in the 15 patients, 1 got solid-pseudopapillary tumor of the pancreas, 3 got non-functional islet cell tumor, 11 got cystadenoma of pancreas.
  • And their tumors were not relapsed.
  • CONCLUSIONS: There is an exact therapeutic effect of middle segment pancreatectomy for benign tumors of the amphi-neck of the pancreas.

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  • (PMID = 21092576.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Ozcan C, Görür K, Talas D, Aydin O: Intramuscular benign lipoma of the sternocleidomastoid muscle: a rare cause of neck mass. Eur Arch Otorhinolaryngol; 2005 Feb;262(2):148-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramuscular benign lipoma of the sternocleidomastoid muscle: a rare cause of neck mass.
  • Intramuscular benign lipoma commonly is found on the extremities, but is extremely rare in the head and neck region.
  • A 29-year-old male patient presented with the complaint of a painless and slowly growing lateral neck mass on the left side.
  • This rare entity should be considered in the differential diagnosis of intramuscularly located neck masses.
  • Complete removal of the tumor can only succeed if planned and performed after a thorough preoperative clinical and radiological assessment in order to prevent recurrences.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Muscle Neoplasms / pathology. Neck Muscles / pathology

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  • [Cites] Otolaryngol Head Neck Surg. 2001 Dec;125(6):658-60 [11743474.001]
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  • (PMID = 15197561.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Supriya M, Denholm S, Palmer T: Seeding of tumor cells after fine needle aspiration cytology in benign parotid tumor: a case report and literature review. Laryngoscope; 2008 Feb;118(2):263-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seeding of tumor cells after fine needle aspiration cytology in benign parotid tumor: a case report and literature review.
  • However, some authors have raised concerns regarding the possibility of tumor cell seeding along the needle track.
  • We present to our knowledge the first case of tumor seeding after FNAC of a benign parotid tumor.
  • This is followed by a review of the literature on tumor seeding after aspiration with fine needles of 20 gauge and smaller and the implications for clinical practice.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biopsy, Fine-Needle / adverse effects. Neoplasm Seeding. Parotid Neoplasms / pathology

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  • (PMID = 18030170.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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21. Zhu D, Sun Y, Yao P, Zheng J, Yang Z: [Experience in treating anterior-lateral benign tumor in middle cranial fossa base through standard facial translocation approach ]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Apr;21(7):304-5, 308

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experience in treating anterior-lateral benign tumor in middle cranial fossa base through standard facial translocation approach ].
  • OBJECTIVE: To observe the feasibility and effect of improved standard facial translocation approach in treating anterior-lateral benign tumor in middle cranial fossa base.
  • METHOD: We excised 10 cases of benign tumor originating from pharynx nasals of pterygopalatine fossa and expanding toward the cavernous sinus of middle cranial fossa, infratemporal fossa or pterygo-maxillary space.
  • CONCLUSION: Reforming facial translocation approach in treating anterior-lateral benign tumor in middle cranial fossa base was safe and obtained ideal curative effect in near future.

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  • (PMID = 17580715.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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22. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • The most common anatomic location was the extremities (58%); the remainder arose on the head and neck (22%), trunk (11%), and in the deep soft tissue of the retroperitoneum, mediastinum, or pelvis (9%).
  • The tumors ranged from 0.5 to 25 cm in size (median, 3.0 cm) and were well circumscribed grossly and microscopically.
  • All tumors were composed of bland ovoid to spindle cells arranged in a storiform pattern with admixed lymphocytes.
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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23. Durgun Y, Firat C, Miman MC, Kirimlioglu H: A rare benign laryngeal tumor: angiomyolipoma. J Craniofac Surg; 2010 Nov;21(6):1956-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare benign laryngeal tumor: angiomyolipoma.
  • Angiomyolipoma is a mesenchymal neoplasm containing adipose tissue, blood vessels, and smooth muscle fibers.
  • Arising most frequently in the kidney, the tumor may exceptionally be at the head and neck region.
  • The tumor was removed by an endolaryngeal approach.

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  • (PMID = 21119467.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Ondik MP, Preston T, Towfighi J, Isaacson JE: Unilateral congenital facial nerve paralysis secondary to a benign epithelioid peripheral nerve sheath tumor. Otol Neurotol; 2007 Dec;28(8):1091-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral congenital facial nerve paralysis secondary to a benign epithelioid peripheral nerve sheath tumor.
  • OBJECTIVE: A benign epithelioid peripheral nerve sheath tumor is described in the setting of congenital facial nerve (FN) paralysis.
  • INTERVENTIONS: Auditory brainstem evoked potential study, gadolinium-enhanced magnetic resonance imaging, temporal bone computed tomography, and transmastoid FN decompression with tumor resection.
  • MAIN OUTCOME MEASURES: Follow-up for tumor recurrence and postoperative FN function.
  • RESULTS: The child underwent a transmastoid FN exploration with resection of a 0.6-cm spherical tumor analyzed to be a benign epithelioid peripheral nerve sheath tumor.
  • CONCLUSION: Benign epithelioid peripheral nerve sheath tumor can cause congenital facial nerve palsy.

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  • (PMID = 18084823.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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25. Seethala RR, LiVolsi VA, Zhang PJ, Pasha TL, Baloch ZW: Comparison of p63 and p73 expression in benign and malignant salivary gland lesions. Head Neck; 2005 Aug;27(8):696-702
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of p63 and p73 expression in benign and malignant salivary gland lesions.
  • In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors.
  • METHODS: The 95 salivary gland tumors were selected from the archives of the Department of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania.
  • RESULTS: In benign lesions, p63 and p73 nuclear reactivity was seen in 46 (92%) of 50 and 47 (94%) of 50 cases, respectively.
  • In malignant tumors, p63 and p73 were seen in 34 (76%) of 45 and 40 (89%) of 45 cases, respectively.
  • Also, p73 was found in tumors with minimal basal/myoepithelial differentiation.
  • CONCLUSIONS: Hence, p63 and p73 expression is retained in both benign and malignant salivary gland tumors with basaloid or myoepithelial differentiation.
  • [MeSH-minor] Biomarkers, Tumor. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 16021638.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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26. Lucas A, Betlloch I, Planelles M, Martínez T, Pérez-Crespo M, Mataix J, Belinchón I: Non-melanocytic benign skin tumors in children. Am J Clin Dermatol; 2007;8(6):365-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-melanocytic benign skin tumors in children.
  • BACKGROUND: Dermatologists often attend children with benign skin tumors and cysts.
  • The decision to perform dermatologic surgery in children may be difficult to make, especially in cases of benign tumors.
  • OBJECTIVE: The objective of this study was to determine the nature of non-melanocytic benign skin tumors amenable to dermatologic surgery in children.
  • METHODS: Histopathologic studies of skin tumors in children treated by our department between January 2004 and December 2005 were studied.
  • Malignant and melanocytic tumors were excluded.
  • Age, sex, type of tumor, diagnostic category, site, size, reason for removal, type of anesthesia, and any other associated disorders were recorded.
  • RESULTS: The records revealed that 121 patients presented 129 non-melanocytic benign skin tumors (73 in boys and 56 in girls).
  • Tumors were located on the head and neck (45.7%), trunk (34.1%), and limbs (20.1%).
  • The reasons that led to removal of the tumors were: increase in the size of the tumor (49%); various types of discomfort, such as severe itching or pain (30%); parental concern (4%); diagnostic uncertainty (16%); and esthetic reasons (1%).
  • CONCLUSION: There is a wide diversity of non-melanocytic benign skin tumors in children, some of which require surgical treatment.
  • Pilomatrixomas appear to be the most frequent benign tumors; there are also high frequencies of infundibular cysts, pyogenic granulomas, and viral tumors.

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  • (PMID = 18039019.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
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27. Hornick JL, Bundock EA, Fletcher CD: Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol; 2009 Oct;33(10):1554-61
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  • [Title] Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors.
  • Benign nerve sheath tumors include neurofibromas, schwannomas, and perineuriomas.
  • In recent years, nerve sheath tumors showing discrete areas of more than one histologic type have been described.
  • We have recently recognized tumors showing hybrid features of schwannoma and soft tissue perineurioma.
  • The tumors arose in a wide distribution: 19 lower limb, 12 upper limb, 6 head and neck, 4 trunk, and 1 colon.
  • Tumor size ranged from 0.7 to 17.5 cm (mean, 3 cm).
  • Most tumors involved superficial subcutis (11 also dermis); only 3 were intramuscular.
  • Histologically, the tumors were usually well circumscribed but unencapsulated, and composed of spindle cells with plump, tapering nuclei, and palely eosinophilic cytoplasm with indistinct cell borders, arranged in a storiform, whorled, and/or lamellar architecture.
  • Only 1 tumor showed infiltrative margins.
  • One tumor showed a plexiform growth pattern.
  • Six tumors showed focally myxoid stroma and 11 contained scattered cells with degenerative nuclear atypia.
  • Mitoses ranged from 0 to 4 per 30 high power fields; 32 tumors had no mitoses.
  • All tumors showed staining for S100 protein and EMA; 98% were positive for CD34, 84% for GFAP, and 80% for claudin-1.
  • Fourteen tumors contained rare neurofilament protein-positive axons.
  • Most tumors were composed of approximately 60% to 70% of Schwann cells and 30% to 40% of perineurial cells.
  • After a mean follow-up of 24 months (range, 6 to 60 mo), 1 tumor recurred locally, after incomplete excision.
  • Benign nerve sheath tumors showing predominantly schwannian cytomorphology and perineurioma-like architecture are composed of an admixture of both cell types.
  • These tumors usually arise in the dermis and subcutis and occur over a wide age range and anatomic distribution.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin-1 / biosynthesis. S100 Proteins / biosynthesis. Young Adult

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  • (PMID = 19623031.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / S100 Proteins
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28. Gardikis S, Kambouri K, Tsalkidis A, Chatzimicael A, Vaos G: Lipoblastoma on the posterior side of the neck. Turk J Pediatr; 2009 May-Jun;51(3):287-9
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  • [Title] Lipoblastoma on the posterior side of the neck.
  • Lipoblastoma is a rare benign pediatric tumor derived from embryonic fat, and only two cases of lipoblastoma located on the posterior side of the neck have been reported in the literature.
  • Here, we present the third case of posterior neck lipoblastoma in a 13-month-old healthy girl, who presented with a firm, posterior cervical mass.
  • The tumor was completely resected following ultrasonography, computerized tomography, and magnetic resonance imaging evaluations.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 19817275.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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29. Tian W, Li X, Li D, Liu X, Lin S, Liang Y: [Imageology features and transoral approach of benign parapharyngeal space tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Nov;24(21):983-6
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  • [Title] [Imageology features and transoral approach of benign parapharyngeal space tumors].
  • OBJECTIVE: To analyze the imageology features of benign parapharyngeal space (PPS) tumors, and also to summarize our experience in removing PPS benign tumors through transoral approach.
  • METHOD: A retrospective review was conducted to 48 patients with benign tumors in PPS during a 10-year period.
  • RESULT: CT scan and MRI often provided complementary information to help the surgeons delineate the size, precise location and likely cause of these tumors.
  • The transoral approach described herein safely allowed for en bloc resection of most benign neoplasms.
  • CONCLUSION: CT or MRI scan can distinguish prestyloid from poststyloid lesions, and to assess the extension of the tumor as well as its relationship with adjacent structures.
  • The transoral approach safely provides access to some benign PPS tumors with a low rate of complications and recurrence as well as traditional transcervical approaches.

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  • (PMID = 21261019.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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30. Karthikeyan P, Paulraj P: An unusual benign tumor of pinna - A case report. Indian J Otolaryngol Head Neck Surg; 2010 Jun;62(2):195-7

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  • [Title] An unusual benign tumor of pinna - A case report.
  • This case is being reported as it is a rare skin adnexal tumor arising from an unusual site.

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  • (PMID = 23120714.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450310
  • [Keywords] NOTNLM ; Hamartoma / Skin adnexal tumor / Tricho folliculoma
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31. Mäkitie A: [Lump on the neck of an adult]. Duodecim; 2009;125(14):1525-32
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  • [Title] [Lump on the neck of an adult].
  • Most neck lumps in adults are benign.
  • Initial investigations can be performed on an outpatient basis, whereas for further examinations the patient should be referred to a unit specialized in the treatment of head and neck tumors.
  • Open biopsy will hamper the further treatment of the tumor and comes into question only in special cases.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy

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  • (PMID = 19711575.001).
  • [ISSN] 0012-7183
  • [Journal-full-title] Duodecim; lääketieteellinen aikakauskirja
  • [ISO-abbreviation] Duodecim
  • [Language] fin
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Finland
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32. Gonçalves AP, Jorge CS, Resende JP, Villela JR, Soares MM, Ramos AV: [Benign hepatic cyst mimicking thyroid carcinoma metastasis]. Arq Bras Endocrinol Metabol; 2009 Aug;53(6):777-82
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  • [Title] [Benign hepatic cyst mimicking thyroid carcinoma metastasis].
  • INTRODUCTION: The follow-up of differentiated thyroid carcinoma (DTC) for detecting persistent or recurrent disease is based on iodine whole body scan (WBS), the evaluation of the tumor marker thyroglobulin (Tg), the anti-thyroglobulin antibody (anti-Tg) and neck ultrasonography (US).
  • Well known false-positive causes of WBS include inflammatory processes, some non-thyroid tumors, kidney or even sebaceous cysts .
  • RESULTS: We enphasize the importance of recognizing benign liver cysts mimicking DTC metastasis.

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  • (PMID = 19893923.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
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33. Melroy CT, Senior BA: Benign sinonasal neoplasms: a focus on inverting papilloma. Otolaryngol Clin North Am; 2006 Jun;39(3):601-17, x
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  • [Title] Benign sinonasal neoplasms: a focus on inverting papilloma.
  • Benign sinonasal neoplasms are a pathologic and clinically varied group of tumors.
  • The treatment algorithm for this tumor has undergone a complex evolution that continues today.

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  • (PMID = 16757234.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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34. Sun ZJ, Cai Y, Zhao YF, Hu X, Zhang W, Chen XM, Lai FM: Epithelioid angiomatous nodule of head and neck. Pathol Res Pract; 2009;205(11):753-7
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  • [Title] Epithelioid angiomatous nodule of head and neck.
  • Epithelioid vascular proliferations comprise a wide morphologic spectrum, ranging from reactive hyperplasia via benign tumor to malignant conditions.
  • Epithelioid angiomatous nodule (EAN) is a recently recognized benign vascular proliferation with distinct clinical and pathological features.
  • We review the literature and present six additional EANs in the head and neck examined by immunohistochemistry.
  • This series indicates that the distribution of EAN in the head and neck region is not uncommon, which is in contrast to what was initially thought.
  • [MeSH-major] Angiomatosis / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangioendothelioma, Epithelioid / diagnosis. Hemangioma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19596525.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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35. Saïji E, Guillou L: [Fibroblastic and myofibroblastic tumors of the head and neck]. Ann Pathol; 2009 Sep;29(4):335-46
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  • [Title] [Fibroblastic and myofibroblastic tumors of the head and neck].
  • Fibroblastic and myofibroblastic tumors of the head and neck are numerous and may develop either in adults or in childhood.
  • They can be benign and nonrecurring, benign but locally recurring, of low-grade of malignancy or fully malignant.
  • This review focuses on several (myo)fibroblastic lesions of the head and neck, including nodular fasciitis and related neoplasms, hemangiopericytoma-like tumor (glomangiopericytoma) of sinonasal passages, nasopharyngeal angiofibroma, desmoid fibromatosis, Gardner-associated fibroma, extrapleural solitary fibrous tumor, inflammatory myofibroblastic tumor, low-grade myofibroblastic sarcoma, and adult-type fibrosarcoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19900638.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 41
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36. Unsal Tuna EE, Ozbek C, Arda N, Ilkdogan E, Dere H, Ozdem C: Development of a Hodgkin disease tumor in the neck of a patient who previously had undergone complete excision of a hyaline-vascular Castleman disease neck mass. Ear Nose Throat J; 2010 Apr;89(4):E20-3
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  • [Title] Development of a Hodgkin disease tumor in the neck of a patient who previously had undergone complete excision of a hyaline-vascular Castleman disease neck mass.
  • Castleman disease is an uncommon cause of a neck mass.
  • A benign lymphoproliferative disorder, it may be seen as a self-limited unicentric process or as a fulminant multicentric disease with systemic symptoms.
  • We report a case of mixed-cellularity Hodgkin disease of the neck in a patient previously diagnosed with hyaline-vascular-type Castleman disease who had undergone complete excision of a neck mass 2 years earlier.
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Hyalin / ultrastructure. Lymph Nodes / pathology. Male. Neck / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Reed-Sternberg Cells / pathology. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 20397132.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Zehlicke T, Punke C, Boltze C, Pau HW: Transient facial palsy in two cases of benign, very rare middle ear tumors (carcinoid tumor and myxoma). Neurologist; 2008 Jan;14(1):52-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient facial palsy in two cases of benign, very rare middle ear tumors (carcinoid tumor and myxoma).
  • OBJECTIVE: Presentation of the clinical features of 2 very rare middle ear tumors in which the guiding symptom was facial palsy.
  • MATERIAL AND METHODS: Illustrative case reports about a myxoma and a carcinoid tumor of the middle ear associated with peripheral facial palsy.
  • Moreover, both tumor entities are typically found in organs other than the ear; if located in the middle ear, those neoplasms grow rather superficially.
  • We report the cases of 2 rare middle ear tumors causing facial palsy.
  • [MeSH-major] Carcinoid Tumor / pathology. Ear Neoplasms / pathology. Ear, Middle / pathology. Facial Paralysis / pathology. Myxoma / pathology

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  • (PMID = 18195660.001).
  • [ISSN] 1074-7931
  • [Journal-full-title] The neurologist
  • [ISO-abbreviation] Neurologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Sawada Y, Ito F, Nakazawa H, Tsushima N, Tomoe H, Aiba M: A rare benign genitourinary tumor in a Japanese male: urinary retention owing to aggressive angiomyxoma of the prostate. Rare Tumors; 2010;2(1):e15

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  • [Title] A rare benign genitourinary tumor in a Japanese male: urinary retention owing to aggressive angiomyxoma of the prostate.
  • Close examination of a 67-year-old Japanese man, who complained of persistent nocturia, revealed that a semitransparent polypoid tumor had developed from the bladder neck to the prostatic urethra obstructing the internal urethral meatus, which resulted in excessive urinary retention and post-renal dysfunction.
  • The tumor was resected by a transurethral procedure and a pathological examination of specimens revealed aggressive angiomyxoma (AAM) of the prostate.

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  • (PMID = 21139944.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994486
  • [Keywords] NOTNLM ; Japan. / angiomyxoma / genitourinary tumor / prostate
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39. Njim L, Dhouibi A, Touil N, Lahmar I, Hadhri R, Moussa A, Zakhama A: Benign osteoblastoma in an unusual mastoid location. Eur Ann Otorhinolaryngol Head Neck Dis; 2010 Nov;127(5):183-5
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  • [Title] Benign osteoblastoma in an unusual mastoid location.
  • INTRODUCTION: Benign osteoblastoma (OB) is an unusual primary bone tumor.
  • The pathologic examination of bone curettage material revealed a benign OB.
  • A complete resection of the tumor was performed later, with no evidence of recurrence at 1 year.
  • Although generally regarded as benign, OB has potential for recurrence and local invasion.

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20951662.001).
  • [ISSN] 1879-730X
  • [Journal-full-title] European annals of otorhinolaryngology, head and neck diseases
  • [ISO-abbreviation] Eur Ann Otorhinolaryngol Head Neck Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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40. Martino F, Avila LF, Encinas JL, Luis AL, Olivares P, Lassaletta L, Nistal M, Tovar JA: Teratomas of the neck and mediastinum in children. Pediatr Surg Int; 2006 Aug;22(8):627-34
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  • [Title] Teratomas of the neck and mediastinum in children.
  • This retrospective study reviews a series of teratomas of the neck and mediastinum aiming at defining the features of these particular locations.
  • Surgical treatment involved total tumor removal and in one case subsequent removal of lymph node metastases.
  • Teratomas of the neck may cause fetal disease and unmanageable neonatal airway obstruction.
  • In contrast, only some mediastinal tumors cause respiratory embarrassment.
  • Although benign, these tumors are sometimes immature and may metastasize to regional lymph nodes.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / surgery. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / surgery. Teratoma / diagnosis. Teratoma / surgery

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  • (PMID = 16838188.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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41. Olsnes C, Heimdal JH, Kross KW, Olofsson J, Aarstad HJ: Viable head and neck tumor spheroids stimulate in vitro autologous monocyte MCP-1 secretion through soluble substances and CD14/lectin-like receptors. Eur Arch Otorhinolaryngol; 2005 Dec;262(12):953-60
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  • [Title] Viable head and neck tumor spheroids stimulate in vitro autologous monocyte MCP-1 secretion through soluble substances and CD14/lectin-like receptors.
  • Biopsies from carcinoma tissue and benign control mucosa from head and neck squamous cell carcinoma (HNSCC) patients were used to establish fragment (F)-spheroids in vitro.
  • [MeSH-major] Antigens, CD14 / pharmacology. Carcinoma, Squamous Cell / metabolism. Chemokine CCL2 / biosynthesis. Head and Neck Neoplasms / metabolism. Monocytes / metabolism. Receptors, Mitogen / metabolism. Spheroids, Cellular / metabolism
  • [MeSH-minor] Autoantibodies / immunology. Coculture Techniques. Culture Media, Conditioned. Enzyme-Linked Immunosorbent Assay. Galactose / pharmacology. Glucose / pharmacology. Humans. Ligands. Mannose / pharmacology. Tumor Cells, Cultured

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  • [Cites] Microbes Infect. 2002 Jul;4(9):903-14 [12106783.001]
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  • (PMID = 16328410.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD14; 0 / Autoantibodies; 0 / CCL2 protein, human; 0 / Chemokine CCL2; 0 / Culture Media, Conditioned; 0 / Ligands; 0 / Receptors, Mitogen; IY9XDZ35W2 / Glucose; PHA4727WTP / Mannose; X2RN3Q8DNE / Galactose
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42. Gonçalves AJ, Carvalho LH, Serdeira K, Nakai MY, Malavasi TR: Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells. Sao Paulo Med J; 2007 Sep 6;125(5):289-91
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells.
  • CONTEXT AND OBJECTIVE: When null, the mu and theta genes of the glutathione S-transferase system (GSTM1 and GSTT1, respectively) are related to malignant tumors affecting the lungs, colon, prostate, bladder and head and neck.
  • The aim of this study was to compare the frequencies of these genes in patients with benign and malignant tumors of the thyroid gland.
  • DESIGN AND SETTINGS: This was a cross-sectional clinical trial carried out in the Head and Neck Surgery Division, Faculdade de Medicina da Santa Casa de São Paulo.
  • METHODS: Samples of thyroid tissue were collected from 32 patients and divided into two groups: benign tumor (A) and malignant tumor (B).
  • CONCLUSION: In this study, there was no relationship between the presence of the GSTT1 and GSTM1 genes and the benign and malignant thyroid tumors.
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cross-Sectional Studies. Female. Genotype. Humans. Male

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  • (PMID = 18094897.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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43. Henrique R, Jerónimo C, Hoque MO, Carvalho AL, Oliveira J, Teixeira MR, Lopes C, Sidransky D: Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions. DNA Cell Biol; 2005 Apr;24(4):264-9
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  • [Title] Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions.
  • 14-3-3Sigma is a putative tumor suppressor gene involved in cell cycle regulation and apoptosis following DNA damage.
  • Here, we investigate the frequency and extent of 14-3-3sigma promoter methylation in benign and cancerous prostate tissues.
  • We examined tumor tissue from 121 patients with prostate carcinoma (PCa), 39 paired high-grade prostatic intraepithelial neoplasias (HGPIN), 29 patients with benign prostate hyperplasia (BPH), as well as four prostate cancer cell lines using quantitative methylation-specific PCR (QMSP).
  • [MeSH-major] Adenocarcinoma / genetics. Biomarkers, Tumor / metabolism. DNA Methylation. Exonucleases / metabolism. Gene Silencing. Neoplasm Proteins / metabolism. Prostatic Hyperplasia / genetics. Prostatic Intraepithelial Neoplasia / genetics. Prostatic Neoplasms / genetics
  • [MeSH-minor] 14-3-3 Proteins. Analysis of Variance. Cell Line, Tumor. Exoribonucleases. Histological Techniques. Humans. Male. Polymerase Chain Reaction / methods. Portugal. Promoter Regions, Genetic / genetics. Prostate / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15812243.001).
  • [ISSN] 1044-5498
  • [Journal-full-title] DNA and cell biology
  • [ISO-abbreviation] DNA Cell Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human
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44. Gorai S, Numata T, Kawada S, Nakano M, Tamaru J, Kobayashi T: Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature. Tohoku J Exp Med; 2007 Jun;212(2):199-205
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  • [Title] Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature.
  • Warthin's tumor (WT), so-called adenolymphoma, is a benign salivary gland tumor with both epithelial and lymphoid histological characteristics, so the histogenesis remains unclear.
  • Treatment consists primarily of tumor removal or conservative follow up.
  • A 102-year-old man presented with a mass in the left side of the neck which was painless but gradually enlarged over 1 month.
  • Tumor removal or careful follow up is recommended in patients with WT because of the potential risk posed by such malignant transformation.
  • [MeSH-major] Adenolymphoma / pathology. Lymphoma, Large B-Cell, Diffuse / etiology. Neck / pathology

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  • (PMID = 17548964.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79; 0 / B-Cell-Specific Activator Protein; 0 / PAX5 protein, human
  • [Number-of-references] 28
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45. Gallo A, Degener AM, Pagliuca G, Pierangeli A, Bizzoni F, Greco A, de Vincentiis M: Detection of human papillomavirus and adenovirus in benign and malignant lesions of the larynx. Otolaryngol Head Neck Surg; 2009 Aug;141(2):276-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of human papillomavirus and adenovirus in benign and malignant lesions of the larynx.
  • SUBJECTS AND METHODS: Biopsy samples were taken from 68 patients with benign and malignant lesions of the larynx.
  • [MeSH-major] Adenoviridae / isolation & purification. Carcinoma, Squamous Cell / virology. Laryngeal Neoplasms / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / complications. Tumor Virus Infections / complications

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  • (PMID = 19643265.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Salama AR, Ord RA: Clinical implications of the neck in salivary gland disease. Oral Maxillofac Surg Clin North Am; 2008 Aug;20(3):445-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical implications of the neck in salivary gland disease.
  • Neck manifestations from salivary gland tissue are most commonly related to inflammation and obstruction of the glands.
  • However, various benign and malignant processes are also seen along a continuum of clinical presentation and behavior.
  • Preoperative diagnostics, including imaging and fine needle aspiration, are key elements in treatment planning, even in the absence of absolute histologic confirmation of tumors.
  • Benign tumor implants in the neck can be managed with conservative surgery, whereas aggressive surgical management, including neck dissection and adjuvant therapy, is generally advocated for malignancy.
  • [MeSH-major] Neck / surgery. Salivary Gland Diseases / diagnosis. Salivary Gland Diseases / surgery. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma / surgery. Carcinosarcoma / diagnosis. Carcinosarcoma / secondary. Carcinosarcoma / surgery. Choristoma / diagnosis. Choristoma / surgery. Humans. Lymphatic Metastasis. Neck Dissection. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery. Ranula / diagnosis. Ranula / surgery. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery

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  • (PMID = 18603202.001).
  • [ISSN] 1558-1365
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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47. Dellian M: [Mass in the neck--the view of the ENT specialist]. MMW Fortschr Med; 2005 Mar 3;147(9):26-7, 29-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mass in the neck--the view of the ENT specialist].
  • A swelling in the neck is a common finding.
  • Underlying causes may be enlarged lymph nodes and cysts, but also benign and malignant tumors.
  • In adults older than 40, however, a malignant tumor may be expected in more that 50% of the cases.
  • Sine early detection is associated with a good prognosis, every mass in the neck must be considered to be potentially malignant.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Hodgkin Disease / diagnosis. Lymphadenitis / diagnosis. Otolaryngology. Patient Care Team. Respiratory Tract Infections / diagnosis

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  • (PMID = 15794350.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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48. Banhiran W, Casiano RR: Endoscopic sinus surgery for benign and malignant nasal and sinus neoplasm. Curr Opin Otolaryngol Head Neck Surg; 2005 Feb;13(1):50-4
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic sinus surgery for benign and malignant nasal and sinus neoplasm.
  • In the recent literature, emphasis has been on the endoscopic surgery of benign tumors, especially inverted papilloma and nasopharyngeal angiofibroma.
  • Other benign neoplasms have also been reported, but only in small case reports.
  • Especially for the more common benign neoplasms, such as inverted papilloma and early stage angiofibroma.
  • Large tumor size, intracranial or orbital extension, and extensive frontal or infratemporal fossa involvement are relative, but not absolute limitations.

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  • (PMID = 15654216.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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49. Wheless SA, McKinney KA, Zanation AM: A prospective study of the clinical impact of a multidisciplinary head and neck tumor board. Otolaryngol Head Neck Surg; 2010 Nov;143(5):650-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A prospective study of the clinical impact of a multidisciplinary head and neck tumor board.
  • OBJECTIVE: There have been no studies undertaken on the effect of the multidisciplinary head and neck tumor board on treatment planning.
  • The objective of this study was to determine the efficacy of the multidisciplinary tumor board in altering diagnosis, stage, and treatment plan in patients with head and neck tumors.
  • SUBJECTS AND METHODS: A prospective study of the discussions concerning 120 consecutive patients presented at a multidisciplinary head and neck tumor board was performed.
  • Results are compared between malignant and benign tumor cohorts.
  • RESULTS: The study population comprised 120 patients with new presentations of head and neck tumors: 84 malignancies and 36 benign tumors.
  • Approximately 27 percent of patients had some change in tumor diagnosis, stage, or treatment plan.
  • Change in treatment was significantly more common in cases of malignancy, occurring in 24 percent of patients versus six percent of benign tumors (P = 0.0199).
  • CONCLUSION: A multidisciplinary tumor board affects diagnostic and treatment decisions in a significant number of patients with newly diagnosed head and neck tumors.
  • The multidisciplinary approach to patient care may be particularly effective in managing malignant tumors, in which treatment plans are most frequently altered.
  • [MeSH-major] Decision Making. Head and Neck Neoplasms / diagnosis. Interdisciplinary Communication. Medical Audit / organization & administration. Medical Oncology / methods. Otolaryngology / methods. Radiation Oncology / methods

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  • [Copyright] Copyright © 2010 American Academy of Otolaryngology–Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20974334.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / T32 DC005360; United States / NIDCD NIH HHS / DC / T32 DC005360
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS248576; NLM/ PMC2994101
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50. Klintworth N, Zenk J, Koch M, Iro H: Postoperative complications after extracapsular dissection of benign parotid lesions with particular reference to facial nerve function. Laryngoscope; 2010 Mar;120(3):484-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postoperative complications after extracapsular dissection of benign parotid lesions with particular reference to facial nerve function.
  • OBJECTIVES/HYPOTHESIS: The desirable extent of surgical intervention for benign parotid tumors remains a matter of controversy.
  • For some time now, extracapsular dissection without exposure of the main trunk of the facial nerve has been favored as an alternative for the treatment of discrete parotid tumors.
  • METHODS: We performed a retrospective analysis of the data from patients in whom extracapsular dissection of a benign parotid tumor had been performed under facial nerve monitoring and as a primary intervention in our department between 2000 and 2008.
  • RESULTS: A total of 934 patients were operated on for a newly diagnosed benign tumor of the parotid gland.
  • CONCLUSIONS: Extracapsular dissection of benign parotid tumors is associated with a low rate of postoperative complications, a fact that is confirmed by the available literature.
  • We therefore recommend that use of this technique always be considered as a means of treating benign parotid tumors as conservatively, that is, as uninvasively, as possible.

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  • (PMID = 20112414.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Zhou YA, Huang JH, Wan CY, Zuo ZB: [Surgical treatment and effect observation of cervical intraspinal benign neoplasms]. Zhongguo Gu Shang; 2009 Nov;22(11):856-8
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  • [Title] [Surgical treatment and effect observation of cervical intraspinal benign neoplasms].
  • OBJECTIVE: To investigate the diagnosis, surgical procedure and clinical outcome of cervical intraspinal benign neoplasm.
  • Symptoms mainly included neck pain, numbness and weakness of the extremities, urinary and fecal incontinence, pyramid signs, etc.
  • The tumors were removed completely in 18 cases, above 60% in 3 cases and 25% with biopsy in 1 case.
  • Cervical stability in 11 cases was restored after removal of tumors.
  • CONCLUSION: The surgical exairesis for cervical intraspinal benign neoplasm has low post-operative recurrence.
  • The main reason of recurrence is not removed the tumor completely.

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  • (PMID = 20084949.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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52. Zhang H, Feng Y, Jiang L: [Tumorectomy by trans-oral approach of macrosis benign neoplasms in parapharyngeal space (reports of 6 cases)]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Jun;24(12):556-8
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  • [Title] [Tumorectomy by trans-oral approach of macrosis benign neoplasms in parapharyngeal space (reports of 6 cases)].
  • OBJECTIVE: To discuss the feasibility of tumorectomy by transoral approach of macrosis benign neoplasms in parapharyngeal space.
  • METHOD: Retrospective analyze 6 patients of macrosis benign neoplasms in parapharyngeal space from January 2005 to May 2008, and all neoplasms were removed by transoral approach.
  • CONCLUSION: Preoperative imaging examination is very important for diagnosis and treatment of benign neoplasm in parapharyngeal space, which is especially helpful to understand the scope of the tumor, and the relationship with carotid artery and vein.
  • On this basis, it is feasible to select the appropriate cases to resect huge benign neoplasm in parapharyngeal space.

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  • (PMID = 20806862.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Chopra R, Morris CG, Friedman WA, Mendenhall WM: Radiotherapy and radiosurgery for benign neurofibromas. Am J Clin Oncol; 2005 Jun;28(3):317-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiotherapy and radiosurgery for benign neurofibromas.
  • The tumor remained locally controlled in all patients.
  • [MeSH-major] Head and Neck Neoplasms / therapy. Neurofibroma / therapy. Radiosurgery

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  • (PMID = 15923807.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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54. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • [Title] Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases.
  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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55. Wang S, Jiang Y, Li C, Yang C, Lin X, Yang D, Chen E: [Resection of invasive head and neck neoplasms involving skull base]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Aug;21(15):703-5, 708
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  • [Title] [Resection of invasive head and neck neoplasms involving skull base].
  • OBJECTIVE: To investigate the operative methods of invasive head and neck neoplasms involving skull base.
  • METHOD: Thirty-two cases with invasive head and neck neoplasms involving anterior and lateral skull base, from 1997 to 2005, were treated with surgical resection.
  • Nine surgical approaches including endoscopic transnasal approach for five cases, combined craniofacial approach for three cases, maxillary resection approach for 15 cases, transpalatal approach for one case, transmandibular approach for one case, lateral neck-mandibular incision approach for two cases, combined retroauricular and neck approach for one case, frontotemporal approach for two cases, and facial translocation approach for two cases were used to resect the tumors.
  • The tumors of the rest 27 cases were totally removed.
  • Eight cases with benign tumor were followed up for six months to eight years without recurrence and no one died.
  • For 24 cases with malignant tumor, survival rates of three and five years were 63.2% (12/19), 41.7% (5/12) respectively.
  • Favorable curative effect could be achieved by resecting tumors totally as possible, protecting important constitutions, and adopting proper reparative techniques.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Skull Base / pathology

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  • (PMID = 17969525.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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56. Mikovic Z, Simic R, Egic A, Opincal TS, Koprivsek K, Stanojevic D, Bogavac M, Popovac M, Mandic V: Intrauterine treatment of large fetal neck lymphangioma with OK-432. Fetal Diagn Ther; 2009;26(2):102-6
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  • [Title] Intrauterine treatment of large fetal neck lymphangioma with OK-432.
  • Lymphangiomas are benign vascular malformations of the lymphatic system and most commonly present in the neck area.
  • The aim of this study was to present our experience with intrauterine intralesional injection of OK-432 in the treatment of neck lymphangiomas.
  • Two cases of large multicystic neck lymphangiomas that were closely situated to the fetal airway were treated by single intralesional injection of OK-432.
  • We noticed a progressive decrease in tumor volume throughout gestation.
  • This report suggests that prenatal intralesional injection of OK-432 might be a safe and effective treatment in selected cases with large fetal neck lymphangiomas.
  • [MeSH-major] Head and Neck Neoplasms / ultrasonography. Lymphangioma / ultrasonography

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  • (PMID = 19752516.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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57. Götte K, Ganssmann S, Affolter A, Schäfer C, Riedel F, Arens N, Finger S, Hörmann K: Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncol Rep; 2005 Nov;14(5):1103-7
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  • [Title] Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses.
  • To date, the underlying genomic changes in benign and malignant tumors of salivary-gland and paranasal-sinus origin are poorly understood.
  • This is due in part to the low incidence of these tumors and the enormous histological variety of tumors within this head and neck region.
  • We examined 58 of these tumors (14 adenoid cystic carcinomas, 9 adenocarcinomas, 5 cylindrical carcinomas, 11 pleomorphic adenomas, and 19 inverted papillomas) by dual fluorescence in situ hybridization (FISH) with centromere-specific probes on six chromosomes (3, 7, 9, 11, 17, and 18) for numerical changes.
  • In cylindrical cell carcinomas, polysomy of chromosomes 7, 9, 11 and 17 was present in the majority of tumors.
  • Disomy is rare, even in benign tumors.
  • Polysomy is more frequent in malignant tumors than in benign.
  • Tetrasomy is found almost only in malignant tumors.
  • In summary, the occurrence of polysomy might reflect a step towards malignancy in tumors of the salivary glands and paranasal mucosa.
  • Polysomy of chromosome 11 could be defined as typical for all investigated histological types of malignant tumor in this region of the head and neck.

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  • (PMID = 16211271.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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58. Moon WJ, Jung SL, Lee JH, Na DG, Baek JH, Lee YH, Kim J, Kim HS, Byun JS, Lee DH, Thyroid Study Group, Korean Society of Neuro- and Head and Neck Radiology: Benign and malignant thyroid nodules: US differentiation--multicenter retrospective study. Radiology; 2008 Jun;247(3):762-70
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  • [Title] Benign and malignant thyroid nodules: US differentiation--multicenter retrospective study.
  • PURPOSE: To retrospectively evaluate the diagnostic accuracy of ultrasonographic (US) criteria for the depiction of benign and malignant thyroid nodules by using tissue diagnosis as the reference standard.
  • A total of 831 patients (716 women, 115 men; mean age, 49.5 years +/- 13.8 [standard deviation]) with 849 nodules (360 malignant, 489 benign) that were diagnosed at surgery or biopsy were included in this study.
  • The US findings for benign nodules were isoechogenicity (sensitivity, 56.6%; specificity, 88.1%; P < .001) and a spongiform appearance (sensitivity, 10.4%; specificity, 99.7%; P < .001).
  • CONCLUSION: Shape, margin, echogenicity, and presence of calcification are helpful criteria for the discrimination of malignant from benign nodules; the diagnostic accuracy of US criteria is dependent on tumor size.

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  • [Copyright] (c) RSNA, 2008.
  • [CommentIn] Radiology. 2008 Jun;247(3):602-4 [18487528.001]
  • (PMID = 18403624.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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59. Saleh HA, Jin B, Barnwell J, Alzohaili O: Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules. Diagn Pathol; 2010;5:9
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  • [Title] Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules.
  • BACKGROUND: Thyroid nodules are common among adults though only a small percentage is malignant, which can histologically mimic benign nodules.
  • METHODS: We investigated immunoexpression in 98 surgically removed benign thyroid nodules including 52 hyperplastic nodules (HN) and 46 follicular/Hurthle cell adenomas (FA), and 54 malignant tumors including 22 follicular carcinoma (FC), 20 classic papillary carcinoma (PTC), and 12 follicular variant papillary carcinoma (FVPC).
  • RESULTS: The staining results showed that malignant tumors express galectin-3, HBME-1, CK19 and Ret oncoprotein significantly more than benign nodules.
  • The sensitivity of these markers for the distinction between benign and malignant lesions ranged from 83.3% to 87%.
  • Immunoexpression was usually diffuse and strong in malignant tumors, and focal and weak in the benign lesions.
  • CONCLUSION: Our findings indicate that these immunomarkers are significantly more expressed in malignant tumors compared to benign lesions and may be of additional diagnostic value when combined with routine histology.
  • [MeSH-major] Biomarkers, Tumor / analysis. Immunohistochemistry. Thyroid Nodule / diagnosis

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  • (PMID = 20181018.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Keratin-19; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; Thyroid cancer, Hurthle cell; Thyroid cancer, papillary
  • [Other-IDs] NLM/ PMC2831001
  • [General-notes] NLM/ Original DateCompleted: 20100524
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60. Macarthur CJ: Head and neck hemangiomas of infancy. Curr Opin Otolaryngol Head Neck Surg; 2006 Dec;14(6):397-405
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  • [Title] Head and neck hemangiomas of infancy.
  • PURPOSE OF REVIEW: Hemangiomas are the most common benign tumor in infancy, affecting approximately 10% of infants.
  • More than half of hemangiomas involve the head and neck.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy. Hemangioma / diagnosis. Hemangioma / therapy

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  • (PMID = 17099347.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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61. Guerrissi JO: Minimal invasive surgery in head and neck: video-assisted technique. J Craniofac Surg; 2010 May;21(3):882-6
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  • [Title] Minimal invasive surgery in head and neck: video-assisted technique.
  • The recent advent of endoscopic procedures has compelled plastic surgeons to reconsider the conventional methods by which the excision of different types of head and neck tumors are classically achieved.
  • This article describes the authors' method for performing a video-assisted surgery for extirpation of benign tumors as branchiogenic cysts, frontal tumors, frontocygomatic cysts, epidermic nasal cysts, and submandibular and sublingual gland diseases.
  • (1) incision, (2) exposure of the tumor, and (3) resection.
  • With the arrival of new surgical techniques, surgeon experience, and advanced endoscopic instruments, the video-assisted surgery can be a safe method of choice in the treatment of the several diseases of the head and neck areas.
  • [MeSH-major] Endoscopy. Head and Neck Neoplasms / surgery. Video-Assisted Surgery

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  • (PMID = 20485074.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. da Motta AC, Tunkel DE, Westra WH, Yousem DM: Imaging findings of a hibernoma of the neck. AJNR Am J Neuroradiol; 2006 Sep;27(8):1658-9
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  • [Title] Imaging findings of a hibernoma of the neck.
  • Hibernoma is an uncommon benign fatty tumor that arises from the vestiges of fetal brown fat.
  • We present a case report of a hibernoma of the neck in an asymptomatic 19-year-old girl and describe the important imaging findings.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16971608.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Duet M, Guichard JP, Rizzo N, Boudiaf M, Herman P, Tran Ba Huy P: Are somatostatin analogs therapeutic alternatives in the management of head and neck paragangliomas? Laryngoscope; 2005 Aug;115(8):1381-4
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  • [Title] Are somatostatin analogs therapeutic alternatives in the management of head and neck paragangliomas?
  • BACKGROUND: Although mostly benign, head and neck paragangliomas require active management because of injury to adjacent neurovascular structures.
  • Surgery, usually preceded by embolization, allows for complete tumor removal.
  • However, surgery carries a significant risk of iatrogenic injury, related to tumor volume.
  • Because paragangliomas express somatostatin receptors with high density, we investigated the effect of a long-acting somatostatin analogue (OCT-LAR) on the size of such tumors to reduce iatrogenic injury and related the percentage of tumor shrinkage to a tracer uptake index calculated on somatostatin receptor scintigraphy (SRS).
  • All 18 tumors were measured by CT scan before treatment and 1 month after the third injection.
  • RESULTS: The average percent tumor shrinkage was 4.0 +/- 10.0%, and the average tumor reduction was 1.0 +/- 3.8 cm (P = .27, NS).
  • Only 2 of the 18 paragangliomas shrank by more than 20%; these two tumors belonged to the only one secreting patient.
  • There was no significant relation between tracer uptake index and tumor response.
  • [MeSH-major] Head and Neck Neoplasms / drug therapy. Octreotide / administration & dosage. Paraganglioma / drug therapy. Somatostatin / analogs & derivatives
  • [MeSH-minor] Adult. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Injections, Intramuscular. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Preoperative Care / methods. Prospective Studies. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Tumor Burden

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  • (PMID = 16094109.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 51110-01-1 / Somatostatin; RWM8CCW8GP / Octreotide
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64. Laskin WB, Fetsch JF, Lasota J, Miettinen M: Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol; 2005 Jan;29(1):39-51
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  • [Title] Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
  • Benign epithelioid peripheral nerve sheath tumors (BEPNSTs) have not been fully characterized, and their relationship to conventional schwannoma and neurofibroma has not been satisfactorily established.
  • The tumors were predominantly dermal/subcutaneous in location (85%) and involved the lower limb (n=15), upper limb (n=11), trunk (n=4), and head/neck (n=3).
  • Microscopically, the tumors were generally well-circumscribed, uninodular, or multinodular masses.
  • Tumors consisted of trabeculae, loosely arranged nodules, and cohesive nests of epithelioid tumor cells immersed in collagenous, myxohyaline, or chiefly myxoid stroma.
  • A bland spindled cell component comprising 5% to 40% of the tumor was noted in 15 cases.
  • Immunohistochemical reactivity for Schwann cell-related markers in tumor cells included S-100 protein (20 of 20 cases), collagen type IV (10 of 10), laminin (8 of 8), nerve growth factor receptor, p75(7 of 8), CD57 (6 of 9), and glial fibrillary acidic protein (8 of 15).
  • Anti-epithelial membrane antigen highlighted perineurial cells in 9 of the 11 encapsulated tumors.
  • Anti-neurofilament protein did not identify intralesional neuraxons in the 10 tumors evaluated.
  • Eighteen tumors were subtyped as epithelioid neurofibromas.
  • Follow-up for 18 patients (median interval, 13.5 years), including 4 patients with tumors exhibiting cytologic atypia, revealed a nondestructive recurrence or persistent disease in 3 patients whose tumors lacked atypia, but no evidence of metastatic spread or tumor-related death.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Middle Aged. Mitotic Index. Neurofibromin 1 / genetics. Neurofibromin 1 / metabolism. Neurofibromin 2 / genetics. Neurofibromin 2 / metabolism. Polymerase Chain Reaction

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  • (PMID = 15613855.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Neurofibromin 2
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65. Baradaranfar MH, Dabirmoghaddam P: Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients. Arch Iran Med; 2006 Jul;9(3):244-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients.
  • OBJECTIVE: To report our experience with endoscopic surgery of benign tumors and tumor-like conditions of the nose and paranasal sinuses.
  • METHODS: The medical records of 105 patients with benign sinonasal tumor, who had undergone endoscopic surgery for removal of their neoplasm between 1997 and 2003, were retrospectively studied.
  • RESULTS: The studied patients included 32 with juvenile nasopharyngeal angiofibroma, 24 with inverted papilloma, 23 with benign fibroosseous lesions, 18 with pyogenic granuloma, 6 with intranasal hemangioma, and 2 with pleomorphic adenoma.
  • Eight cases of recurrent tumor--2 angiofibroma, 4 inverted papilloma, 1 fibrous dysplasia, and 1 osteoma--were noted and managed endoscopically alone or in combination with Caldwell-Luc approach.
  • CONCLUSION: Endoscopic surgery is a valuable tool for removal of benign tumors of the nose and paranasal sinuses in the hands of an experienced surgeon.

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  • (PMID = 16859060.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Iran
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66. Pertile D, Scabini S, Romairone E, Scordamaglia R, Rimini E, Ferrando V: Gastric Abrikosoff tumor (granular cell tumor): case report. G Chir; 2010 Oct;31(10):433-4
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  • [Title] Gastric Abrikosoff tumor (granular cell tumor): case report.
  • Granular Cells Tumor (GCT), also called Abrikosoff tumor, is very uncommon lesion of neural derivation.
  • It is characterized by the presence of granular cell; benign and malignamt counterparts are known, even if the second ones are rare.
  • Any localisation is possible, although surface lesions (head, neck, trunk, extremities) are far more common than visceral ones (esophagus, stomach, small and large bowel, larynx, bronchi, gallbladder and biliary tract).
  • Surgical en-block excision is curative for both benign an malignant forms.
  • We report the case of a 45 year old man who had a cytologic diagnosis of fusocellular stromal tumor of the gastric fundus during examination for gastritis.
  • [MeSH-major] Granular Cell Tumor. Stomach Neoplasms

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  • (PMID = 20939949.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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67. Mendes RA, Carvalho JF, Waal Iv: An overview on the expression of cyclooxygenase-2 in tumors of the head and neck. Oral Oncol; 2009 Oct;45(10):e124-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An overview on the expression of cyclooxygenase-2 in tumors of the head and neck.
  • Cyclooxygenase-2 (COX-2) levels are increased in various tumors, particularly those involving the esophagus, stomach, breast, pancreas, lung, colon, skin, urinary bladder, prostate and head and neck.
  • Thus, the literature shows increasing evidence that overexpression of the COX-2 plays an important role in tumor growth and spread of tumors by interfering with different biological processes such as cell proliferation, cellular adhesion, immune surveillance, apoptosis, and angiogenesis.
  • Furthermore, the expression of COX-2 might shed some light over the physiopathology and clinical behavior of tumors of the head and neck, including benign odontogenic neoplasms of the jaws with an aggressive behavior, such as keratocystic odontogenic tumors (KCOT).
  • Ultimately, the research of molecular markers associated with the biological behavior of tumors will help to understand the underlying molecular mechanisms and to predict the clinical outcome, leading to the development of new therapeutic applications, such as molecular-targeted treatment and patient tailored therapy.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Head and Neck Neoplasms / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 19457709.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Prostaglandins; EC 1.14.99.1 / Cyclooxygenase 2
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68. Hox V, Vander Poorten V, Delaere PR, Hermans R, Debiec-Rychter M, Sciot R: Extramammary myofibroblastoma in the head and neck region. Head Neck; 2009 Sep;31(9):1240-4
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  • [Title] Extramammary myofibroblastoma in the head and neck region.
  • BACKGROUND: Mammary myofibroblastoma is a benign mesenchymal tumor of the breast.
  • CONCLUSION: We describe this case because of the unusual location of this rare tumor.
  • SCL has a predilection site in the posterior neck.
  • Both tumors show the same clinical behavior, a close histological resemblance, and their cells are both immunoreactive for CD34 and CD10.
  • [MeSH-major] Head and Neck Neoplasms. Neoplasms, Muscle Tissue

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  • (PMID = 19132718.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Kross KW, Heimdal JH, Olsnes C, Olofsson J, Aarstad HJ: Head and neck squamous cell carcinoma spheroid- and monocyte spheroid-stimulated IL-6 and monocyte chemotactic protein-1 secretion are related to TNM stage, inflammatory state and tumor macrophage density. Acta Otolaryngol; 2005 Oct;125(10):1097-104
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  • [Title] Head and neck squamous cell carcinoma spheroid- and monocyte spheroid-stimulated IL-6 and monocyte chemotactic protein-1 secretion are related to TNM stage, inflammatory state and tumor macrophage density.
  • Monocyte fragment (F)-spheroid-stimulated and F-spheroid IL-6 and monocyte chemotactic protein (MCP)-1 secretion are related to inflammatory state, macrophage density and the TNM stage of patients with head and neck squamous cell carcinoma (HNSCC).
  • In series II (n=17) the TNM stage, donor inflammatory state, macrophage density and the secretion of F-spheroid- and monocyte F-spheroid-stimulated IL-6, MCP-1 and tumor necrosis factor (TNF)-alpha were determined.
  • Malignant (M) F-spheroids secreted more MCP-1 than benign (B) F-spheroids.
  • [MeSH-major] Carcinoma, Squamous Cell / secretion. Chemokine CCL2 / secretion. Head and Neck Neoplasms / secretion. Interleukin-6 / secretion. Monocytes / secretion. Spheroids, Cellular / secretion
  • [MeSH-minor] Blood Sedimentation. Cell Count. Coculture Techniques. Humans. Macrophages. Neoplasm Staging. Tumor Cells, Cultured. Tumor Necrosis Factor-alpha / secretion


70. Papagelopoulos PJ, Mavrogenis AF, Benetos IS, Papaparaskeva K, Galanis EC, Soucacos PN: Ewing's sarcoma of the hip presenting as a benign cystic lesion. J Surg Orthop Adv; 2007;16(2):84-8
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  • [Title] Ewing's sarcoma of the hip presenting as a benign cystic lesion.
  • A 14-year-old girl with a Ewing's sarcoma of the left femoral head and neck is presented.
  • The imaging features mimicked a benign cystic lesion.
  • The patient was treated with chemotherapy, wide tumor resection, and proximal femoral reconstruction using an allograft-prosthesis composite.

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  • [CommentIn] J Surg Orthop Adv. 2007 Winter;16(4):207; author reply 207 [18053405.001]
  • (PMID = 17592716.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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71. Chen WL, Ye JT, Yang ZH, Huang ZQ, Zhang DM, Wang K: Reverse facial artery-submental artery mandibular osteomuscular flap for the reconstruction of maxillary defects following the removal of benign tumors. Head Neck; 2009 Jun;31(6):725-31
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  • [Title] Reverse facial artery-submental artery mandibular osteomuscular flap for the reconstruction of maxillary defects following the removal of benign tumors.
  • METHODS: Eight maxillary defects following benign tumor ablation were repaired with reverse facial artery-submental artery mandibular osteomuscular flaps.

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc.
  • (PMID = 19260126.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Bhatnagar AK, Gerszten PC, Ozhasaglu C, Vogel WJ, Kalnicki S, Welch WC, Burton SA: CyberKnife Frameless Radiosurgery for the treatment of extracranial benign tumors. Technol Cancer Res Treat; 2005 Oct;4(5):571-6
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  • [Title] CyberKnife Frameless Radiosurgery for the treatment of extracranial benign tumors.
  • Limited data exists for the use of radiosurgery for benign extracranial tumors.
  • The purpose of this study was to evaluate the feasibility, toxicity, and local control of patients with benign extracranial lesions treated with the CyberKnife Frameless Radiosurgery System.
  • From September 2001 thru January 2004, 59 benign tumors in 44 patients were treated using the CyberKnife a frameless image-guided radiosurgery system.
  • Of these tumors, there were 21 neurofibromas, ten schwannomas, eight meningiomas, eight hemangioblastomas, seven paragangliomas, two hemangiopericytomas, one pseudotumor, one ependymoma, and one arteriovenous malformation (AVM).
  • The anatomic locations of these tumors were spinal (25 cervical, four thoracic, 14 lumbar, and two sacral), neck (eight), orbital (three), brainstem (one), and foramen magnum (one).
  • The median tumor dose delivered was 16.0 Gy to the 80% isodose line (range 10-31 Gy).
  • The median tumor volume was 4.3 cc (range 0.14-98.6 cc).
  • This study suggests that CyberKnife Radiosurgery is a safe and efficacious treatment modality for benign tumors, even for those patients with recurrent previously irradiated lesions.

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  • (PMID = 16173828.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Baliga M, Uppal N, Ramanathan A: Schwannomas of the head and neck: a case series. J Maxillofac Oral Surg; 2009 Sep;8(3):283-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannomas of the head and neck: a case series.
  • Schwannomas are relatively slow growing benign tumors of the nerve sheath with a well developed capsule.
  • We present four cases of this tumor that occurred in the head and neck.
  • The differential diagnosis of small painless nodules in head and neck must include schwannomas as it is likely that nerve sheath neoplasms are more common than previously reported.
  • However, due to benign nature and low recurrence prognosis is excellent.

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  • [Cites] J Oral Surg. 1977 Mar;35(3):235-6 [264530.001]
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  • (PMID = 23139527.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454230
  • [Keywords] NOTNLM ; Antoni A variants / Antoni B variants / Nerve sheath / Neurilemoma
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74. Kozakiewicz J, Teodorowicz E, Motyka M, Szczechowski K: [A neck chemodectoma--survey of literature and description of one case of malignant chemodectoma]. Otolaryngol Pol; 2005;59(4):623-6
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  • [Title] [A neck chemodectoma--survey of literature and description of one case of malignant chemodectoma].
  • Neck tumors are one of the most difficult diagnostic and therapeutic problems of the contemporary otolaryngology.
  • The goal of the study is to pay attention to the necessity of careful diagnosis and introducing computer tomography (CT) as a standard of neck tumors treatment procedure in order not to miss exceptionally rarely neck chemodectoma and to plan treatment process properly.
  • Chemodectoma is a tumor coming from the parasympathetic part of the nervous system.
  • The authors present a case of neck chemodectoma with malignant character in a 37-years-old woman with 10-years history of suspicion of a benign cyst.
  • [MeSH-major] Head and Neck Neoplasms. Paraganglioma, Extra-Adrenal

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  • (PMID = 16273874.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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75. Rubaltelli L, Stramare R, Tregnaghi A, Scagliori E, Cecchelero E, Mannucci M, Gallinaro E, Beltrame V: The role of sonoelastography in the differential diagnosis of neck nodules. J Ultrasound; 2009 Sep;12(3):93-100

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  • [Title] The role of sonoelastography in the differential diagnosis of neck nodules.
  • Ultrasonographic studies of the neck can reveal the nonpalpable thyroid nodules, but the nature of these lesions generally has to be established on the basis of FNAB findings.
  • Indeed, in 5 lymph nodes with sonographic features consistent with malignancy, sonoelastography revealed diffuse elasticity that was indicative of benign disease, which was confirmed by pathological studies.
  • Other nodular lesions of the neck can also be evaluated with sonoelastography, including enlarged parotid glands, but the data in the literature are too limited to allow hypotheses on the role of this imaging modality in this field.
  • Sonoelastography is rapid and simple to perform, and it appears to be a potentially useful tool for the differential diagnosis of neck nodules.
  • Our experience with these lesions indicates that diffuse elasticity is strongly correlated with benign disease.

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  • (PMID = 23396686.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3552973
  • [Keywords] NOTNLM ; Technology assessment / Thyroid / Tumor
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76. Al-Sindi K, Al-Shehabi MH, Al-Khalifa SA: Inflammatory myofibroblastic tumor of paranasal sinuses. Saudi Med J; 2007 Apr;28(4):623-7
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  • [Title] Inflammatory myofibroblastic tumor of paranasal sinuses.
  • Inflammatory myofibroblastic tumors IMTs are clinico-pathologically distinctive but biologically controversial entities; they rarely affect the head and neck region and usually follow a benign clinical course after radical excision.
  • Tumor cells were immunoreactive for vimentin, and smooth muscle actin, negative for desmin, S-100, p53, Cyclin D1, and bcl-2.


77. Zheng JW, Wang YA, Zhou GY, Zhu HG, Ye WM, Zhang ZY: [Head and neck hemangiomas: how and when to treat]. Shanghai Kou Qiang Yi Xue; 2007 Aug;16(4):337-42
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  • [Title] [Head and neck hemangiomas: how and when to treat].
  • Hemangiomas are common benign vascular tumors of infancy characterized by a proliferative growth phase followed by very slow inevitable regression (involutive phase) between one to ten years of age, about 60% to 70% of the lesions are found in the head and neck region.
  • There are many treatment modalities reported in the literature for head and neck hemangiomas, including wait and see policy, drug therapy, sclerotherapy (steroids, bleomycin), cryotherapy, isotope radiotherapy, laser therapy, and surgical therapy.
  • Based on our clinical experience on 250 cases and literature review, a rational treatment regime for head and neck hemangioma was proposed in this study:.
  • A successful treatment of hemangiomas should be individualized and based on the size of the tumor, the localization, and the therapies available.
  • [MeSH-major] Head and Neck Neoplasms / therapy. Hemangioma / therapy

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  • (PMID = 17924011.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] China
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78. Ferlito A, Elsheikh MN, Manni JJ, Rinaldo A: Paraneoplastic syndromes in patients with primary head and neck cancer. Eur Arch Otorhinolaryngol; 2007 Mar;264(3):211-22
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  • [Title] Paraneoplastic syndromes in patients with primary head and neck cancer.
  • Paraneoplastic syndromes represent the clinical manifestations of the indirect and remote effects produced by tumor metabolites or other products.
  • The clinical spectrum of the various paraneoplastic syndromes related to primary malignancies of the head and neck region is presented.
  • A review of the literature on paraneoplastic syndromes in patients with primary head and neck cancer was carried out.
  • Paraneoplastic syndromes related to primary malignancies of the head and neck region can be categorized as: endocrine, cutaneous or dermatologic, hematologic, neurologic, osteoarticular or rheumatologic, ocular syndromes.
  • Sometimes, paraneoplastic syndromes can be more serious than the consequences of the primary tumor itself and can precede, follow or be concurrent to the diagnosis of a malignancy; moreover, they can dominate the clinical picture and thus lead to errors with respect to the origin and type of the primary tumor.
  • Physicians who deal with cancer-associated syndromes should be able to differentiate the paraneoplastic syndromes from the benign disorders that mimic them.
  • Patients with a suspected paraneoplastic disorder should undergo a complete panel of laboratory studies, in addition to imaging studies and endoscopy.
  • Identification of paraneoplastic syndromes allow the clinician to make an early diagnosis and to provide adequate treatment of tumors, with a favorable oncologic outcome and improved life expectancy for the patient.
  • These syndromes can follow the clinical course of the tumor and thus be useful for monitoring its evolution.
  • [MeSH-major] Chorionic Gonadotropin, beta Subunit, Human / metabolism. Head and Neck Neoplasms. Paraneoplastic Syndromes

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  • (PMID = 17206403.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 126
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79. Valdez TA, Desai U, Volk MS: Recurrent fetal rhabdomyoma of the head and neck. Int J Pediatr Otorhinolaryngol; 2006 Jun;70(6):1115-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent fetal rhabdomyoma of the head and neck.
  • A congenital fetal rhabdomyoma involving the head and neck region diagnosed prenatally by ultrasound and MRI was surgically excised without complications.
  • The patient presented with recurrence of the tumor fourteen months after the initial surgery.
  • Extracardiac rhabdomyomas are extremely rare benign tumors.
  • [MeSH-major] Head and Neck Neoplasms / congenital. Neoplasm Recurrence, Local / pathology. Rhabdomyoma / congenital

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  • (PMID = 16406074.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 11
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80. Khademi B, Taraghi A, Mohammadianpanah M: Anatomical and histopathological profile of head and neck neoplasms in Persian pediatric and adolescent population. Int J Pediatr Otorhinolaryngol; 2009 Sep;73(9):1249-53
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  • [Title] Anatomical and histopathological profile of head and neck neoplasms in Persian pediatric and adolescent population.
  • BACKGROUND: Neoplasms of the head and neck region are relatively uncommon in childhood.
  • The present study aimed to describe and compare the anatomical and histopathological distribution of head and neck neoplasms in Persian pediatric and adolescent population.
  • METHODS: Patients who presented with primary head and neck tumors were included in this study.
  • Orbital and skin tumors and neoplasms with secondary (metastatic) involvement of the head and neck were excluded from the study.
  • Based on the data obtained from a tertiary referral hospital tumor registry and oncology department, a total of 152 benign and malignant neoplasms of the head and neck in patients aged 19 years or younger (99 boys), whom were reported to this institution between 2000 and 2007, were analyzed in this study.
  • There were 136 (89.5%) malignant tumors and 16 (10.5%) benign neoplasms.
  • CONCLUSION: The most frequent primary site, malignant histopathological type, and male-female ratio in our study were comparable with other reported series; however, the ratio of benign to malignant lesions is different from most studies.
  • [MeSH-major] Carcinoma / epidemiology. Head and Neck Neoplasms / epidemiology. Lymphoma / epidemiology. Sarcoma / epidemiology

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  • (PMID = 19525017.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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81. Jaswal A, Jana AK, Sikder B, Jana U, Nandi TK: Benign osteoblastoma of maxillary sinus: A rare presentation. Indian J Otolaryngol Head Neck Surg; 2007 Mar;59(1):80-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign osteoblastoma of maxillary sinus: A rare presentation.
  • Benign osteoblastoma of paranasal sinuses is a rare tumor of the 2(nd) decade of life with only few cases reported till date.
  • Here we present a case of benign osteoblastoma in a 8 year old girl presenting with a large intranasal mass seen through nostril and leading to facial deformity.

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  • (PMID = 23120398.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451729
  • [Keywords] NOTNLM ; Benign osteoblastoma / Sino-nasal tumor
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82. Sharma A, Ngan BY, Sándor GK, Campisi P, Forte V: Pediatric aggressive fibromatosis of the head and neck: a 20-year retrospective review. J Pediatr Surg; 2008 Sep;43(9):1596-604
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric aggressive fibromatosis of the head and neck: a 20-year retrospective review.
  • Aggressive fibromatosis in children is a rare, benign condition that is locally infiltrative and destructive.
  • It often presents as a rapidly growing, painless lump in the head and neck region.
  • Recently, nuclear beta-catenin expression has been suggested as a tumor-specific marker for aggressive fibromatosis (desmoid).
  • AIM: The aims of the study were to review our experience of the presentation, management, and treatment outcome of pediatric aggressive fibromatosis in the head and neck and to identify the presence of the desmoid tumor marker beta-catenin within this population.
  • METHOD: The study was conducted as a retrospective case review of children diagnosed with aggressive fibromatosis in the head and neck for a period of 20 years and a review of the literature.
  • Pathologic review of the original tumor specimens was undertaken for evidence of positive tumor margins and presence of nuclear beta-catenin expression.
  • This included 7 patients with extension of the tumor to the resection margin; all had good long-term outcomes with no disease progression.
  • Pediatric fibromatosis though aggressive is still a benign condition, and careful thought should be taken before considering adjuvant chemoradiotherapy.
  • Nuclear beta-catenin expression should not be considered a specific tumor marker for pediatric aggressive fibromatosis of the head and neck.
  • Pediatric aggressive fibromatosis in this region may be a distinct subtype of desmoid tumor from its adult form.
  • [MeSH-major] Fibromatosis, Aggressive. Head and Neck Neoplasms

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  • (PMID = 18778992.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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83. Daniel E, McGuirt WF Sr: Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience. Am J Otolaryngol; 2005 Mar-Apr;26(2):96-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience.
  • OBJECTIVES: The aim of this study is to review salivary tumors arising from heterotopic salivary inclusions in the periparotid and cervical lymph nodal tissues over a 25-year span.
  • METHODS: A retrospective chart review revealed 24 patients with asymptomatic neck masses treated between 1976 and 2001, whose pathology demonstrated heterotopic salivary tissue or neoplasms arising from heterotopic salivary tissue.
  • RESULTS: Nine cases were benign periparotid lymph nodes with heterotopic salivary inclusions, 3 of which had multimodal involvement.
  • Fifteen cases of heterotopic salivary tumors were identified.
  • The benign tumors were predominantly Warthin's tumor (8) with 1 pleomorphic adenoma.
  • Malignant tumors included mucoepidermoid (3), acinic cell (2), and adenocarcinoma (1).
  • Patients were treated by a superficial parotidectomy, neck dissection, or simple excision depending on site and preoperative workup.
  • Among the 15 tumor patients, follow-up ranged from 1 month to 17 years.
  • Tumorigenic changes arise from heterotopic nodal inclusions, and although infrequent, should be considered in the differential diagnosis for isolated neck/periparotid masses and parotid Warthin's tumor.
  • Suggested management, after a thorough clinical exam/needle aspiration biopsy, includes an imaging survey of the parotid gland and neck lymphatics with an appropriate resection to include a simple excision, parotidectomy, neck dissection, and/or irradiation as indicated.
  • Isolated low-grade malignant lesions/benign lesions are adequately managed by excision or parotidectomy alone.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Follow-Up Studies. Humans. Lymph Nodes. Middle Aged. Neck. Retrospective Studies

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  • (PMID = 15742261.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Fischer M: Investigation of a broad-spectrum PCR assay for human papillomaviruses in screening benign lesions of the upper aerodigestive tract. ORL J Otorhinolaryngol Relat Spec; 2005;67(4):237-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Investigation of a broad-spectrum PCR assay for human papillomaviruses in screening benign lesions of the upper aerodigestive tract.
  • BACKGROUND: A variety of different human papillomavirus (HPV) types can be found in benign and malignant lesions of the upper aerodigestive tract.
  • RESULTS: A total of 27 biopsies from laryngeal papillomas (9), exophytic (3) and inverted (6) papillomas of the nasal cavity or paranasal sinuses, papillomas of the uvula or soft palate (5), leukoplakias of the larynx (2), seborrheic keratosis (1) and granulation tumor of the tongue (1) were analyzed by the broad-spectrum PCR system.
  • CONCLUSIONS: It was shown that the applied broad-spectrum PCR system is a reliable tool in the detection of HPV DNA in benign lesions of the upper aerodigestive tract.
  • [MeSH-major] Head and Neck Neoplasms / virology. Mass Screening. Papillomavirus Infections / diagnosis. Polymerase Chain Reaction / methods

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  • (PMID = 16276120.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA Primers
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85. Oudidi A, Hachimi H, El Alami MN: [Desmoid tumor of the parotid gland]. Rev Stomatol Chir Maxillofac; 2006 Dec;107(6):470-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Desmoid tumor of the parotid gland].
  • INTRODUCTION: Desmoid tumor is a benign microscopic tumor that belongs to the group of the deep fibromatosis.
  • It usually arises from facial or musculoaponeurotic structures in the abdomen but rarely is located in the head or neck.
  • Physical examination revealed a tumor in the parotid gland, which was hard and adherent deeply, measuring 4 cm/3 cm and sensitive to palpation; without satellite nodes nor facial paralysis.
  • Pathology was in favor of a desmoid tumor.
  • DISCUSSION: Desmoid tumors are deep fibromatosis characterized by their slow growth and especially by considerable infiltration of the adjacent structures but without potential for metastasis.

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  • (PMID = 17195002.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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86. Al-Harthy M, Al-Harthy S, Al-Otieschan A, Velagapudi S, Alzahrani AS: Comparison of pheochromocytomas and abdominal and pelvic paragangliomas with head and neck paragangliomas. Endocr Pract; 2009 Apr;15(3):194-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of pheochromocytomas and abdominal and pelvic paragangliomas with head and neck paragangliomas.
  • OBJECTIVE: To compare clinical, radiologic, and pathologic characteristics, as well as management and outcomes, in a series of pheochromocytomas, abdominal and pelvic paragangliomas, and pelvic paragangliomas with head and neck paragangliomas.
  • We searched pathology and medical record databases under the terms pheochromocytoma, paraganglioma, head and neck tumors, carotid body tumors, glomus jugulare, and neuroendocrine tumors.
  • We compared clinical, radiologic, and pathologic characteristics, as well as management and outcomes, between patients with pheochromocytoma, abdominal and pelvic paraganglioma, and head and neck paraganglioma.
  • RESULTS: Eighty-six patients were included (46 with head and neck paraganglioma, 23 with pheochromocytoma, and 17 with abdominal or pelvic paraganglioma).
  • Compared with patients with head and neck paraganglioma, patients with pheochromocytoma or abdominal and pelvic paraganglioma were younger (35.7 +/- 16 years vs 43 +/- 17 years, P = .042) and were more likely to have the classic triad associated with catecholamine hypersecretion of palpitation, excessive sweating, and headache (40% vs 0%, P<.001); hypertension (70% vs 37%, P = .005); and benign tumors (65% vs 43%, P = .03).
  • Patients with head and neck paraganglioma and patients with pheochromocytoma/abdominal and pelvic paraganglioma were not different in female to male ratios (27:19 vs 29:11, respectively, P = .18), tumor size (5.8 +/- 2.7 cm vs 5.7 +/- 3 cm, respectively; P = .85), or remission rate (43% vs 60%, respectively, P = .13).
  • CONCLUSIONS: Head and neck paraganglioma are similar to pheochromocytoma and abdominal and pelvic paraganglioma in size and outcome, but occur at an older age, lack hyperadrenergic manifestations, and are more likely to have local pressure effects and result in persistent disease.
  • [MeSH-major] Abdominal Neoplasms / epidemiology. Adrenal Gland Neoplasms / epidemiology. Head and Neck Neoplasms / epidemiology. Paraganglioma / epidemiology. Pelvic Neoplasms / epidemiology. Pheochromocytoma / epidemiology
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Disease Progression. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Tumor Burden. Young Adult

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  • (PMID = 19364686.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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87. Sevilla MA, Hermsen MA, Weiss MM, Grimbergen A, Balbín M, Llorente JL, Rodrigo JP, Suárez C: Chromosomal changes in sporadic and familial head and neck paragangliomas. Otolaryngol Head Neck Surg; 2009 May;140(5):724-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosomal changes in sporadic and familial head and neck paragangliomas.
  • OBJECTIVE: Paragangliomas (PGLs) of the head and neck are benign neoplasms derived from the autonomic nervous system.
  • The aim of this study was to compare somatic DNA copy number changes in tumors of familial and sporadic origin.
  • [MeSH-major] Head and Neck Neoplasms / genetics. Paraganglioma / genetics. Succinate Dehydrogenase / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Chi-Square Distribution. Comparative Genomic Hybridization. DNA Mutational Analysis. Female. Germ-Line Mutation. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-ret / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 19393419.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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88. Gajda M, Welzel C, Holzhausen HJ, Jamali Y, Schrom T, Hauptmann S, Bloching M: [Multifocal adult rhabdomyoma of the neck: a rare entity]. Otolaryngol Pol; 2005;59(6):883-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multifocal adult rhabdomyoma of the neck: a rare entity].
  • Extracardiac rhabdomyoma comprise 2% of all tumors of skeletal muscle differentiation.
  • Seventy percent of extracardiac rhabdomyoma occur in the head and neck region and have been subclassified into adult and fetal types.
  • A review of the world literature revealed about 19 acceptable cases of benign, multifocal adult-type rhabdomyoma with a distinct male predominance.
  • The pathogenesis of this benign striated muscle tumor is still unclear.
  • These slow-growing tumors remain asymptomatic for a long period.
  • The diagnosis of head and neck rhabdomyoma is based on histology and immunhistochemical studies.
  • The differential diagnoses of rhabdomyoma in adults are myoblastoma or Abrikossof tumor, reticulohistiocytoma, rhabdomyosarcoma and hibernoma.
  • Although adult rhabdomyomas have a distinct histology, they often are mistaken for a variety of other lesions, particularly Abrikossof tumor.
  • Electron microscopic studies confirmed the tumor's myogenic origin.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Rhabdomyoma / pathology

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  • (PMID = 16521457.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 16
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89. Dickson PV, Davidoff AM: Malignant neoplasms of the head and neck. Semin Pediatr Surg; 2006 May;15(2):92-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant neoplasms of the head and neck.
  • Head and neck masses represent a common clinical entity in children.
  • The differential diagnosis is broad, and expeditiously distinguishing benign from malignant masses is critical for instituting a timely multidisciplinary approach to the management of malignant lesions.
  • Neoplasms of the head and neck account for approximately 5% of all childhood malignancies.
  • A diagnosis of malignancy may represent a primary tumor or metastatic foci to cervical nodes.
  • In this review, we discuss the general approach to evaluating suspicious masses and adenopathy in the head and neck region and summarize the most common malignant neoplasms of the head and neck with regard to their incidence, clinical presentation, diagnostic evaluation, staging, and management.
  • Thyroid, parathyroid, and salivary gland tumors are discussed elsewhere in this issue of Seminars in Pediatric Surgery.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Lymph Nodes / anatomy & histology. Lymphatic Diseases / diagnosis. Lymphatic Diseases / therapy. Lymphoma / diagnosis. Lymphoma / therapy. Neck. Neuroblastoma / diagnosis. Neuroblastoma / therapy. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / therapy

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  • (PMID = 16616312.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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90. Ohta N, Fukase S, Watanabe T, Ito T, Aoyagi M: Effects and mechanism of OK-432 therapy in various neck cystic lesions. Acta Otolaryngol; 2010 Nov;130(11):1287-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects and mechanism of OK-432 therapy in various neck cystic lesions.
  • CONCLUSION: Our results confirmed that OK-432 therapy is simple, easy, safe, and effective and can be used as a substitute for surgery in the treatment of benign neck cysts.
  • OBJECTIVE: The aim of this study was to evaluate the outcome and mechanism of action of OK-432 therapy in benign neck cysts.
  • METHODS: We tried OK-432 therapy in 83 patients with benign neck cysts between April 1997 and August 2009.
  • Levels of various cytokines, including tumor necrosis factor, interleukin-8, interleukin-6, interferon gamma, and vascular endothelial growth factor, were significantly elevated in each aspirate after OK-42 therapy.
  • [MeSH-minor] Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / adverse effects. Biomarkers / metabolism. Branchioma / drug therapy. Female. Fever / etiology. Follow-Up Studies. Humans. Injections, Intralesional. Lymphangioma, Cystic / drug therapy. Male. Middle Aged. Neck. Ranula / drug therapy. Remission Induction. Retrospective Studies. Suction. Thyroglossal Cyst / drug therapy

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  • (PMID = 20450399.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers; 0 / Cytokines; 39325-01-4 / Picibanil
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91. Lian X, Zhao J, Hou T, Ma H, Chen Z: Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report. Spine (Phila Pa 1976); 2006 Nov 1;31(23):E895-9
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  • [Title] Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report.
  • STUDY DESIGN: A case report of a rare benign osteoblastoma successfully treated with total en bloc excision.
  • SUMMARY OF BACKGROUND DATA: A rare case of massive benign osteoblastoma stemming from left side lamina of C7 and extension to spinal canal from C6 to T1 resulting in spinal cord compressed severely is reported.
  • METHODS: A 13-year-old girl complained of gradually increasing pain of her lower part of the neck and left shoulder radiating to the left upper extremity, and the neurologic deficits were found in physical examination.
  • A massive neoplasm located in intraspinal cervicothoracic junction and the spinal cord compressed severely was shown in radiographs, MRI, and CT.
  • The neoplasm was removed totally with instrumentation performed in surgical intervention.
  • Recurrence of the tumor was not seen at the final follow-up.

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  • (PMID = 17077728.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Göktas O, Lammert I: [Neurilemmoma of the head and neck--report of 3 cases]. Laryngorhinootologie; 2006 Aug;85(8):582-5
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  • [Title] [Neurilemmoma of the head and neck--report of 3 cases].
  • BACKGROUND: Neurilemmoma are benign tumors of the nerve-sheath, also known as schwannoma.
  • Beside intracranial manifestation, neurilemmoma are found at other peripheral nerves of the head and neck.
  • The histological examination showed two types of Antoni-A-neurilemmoma, whereas one tumor was found with mixed type A and B-neurilemmoma.
  • CONCLUSION: Although extracranial neurilemmoma of retropharygeal space, neck or supraglottic larynx are rare tumors, neurilemmoma should be involved in differential diagnosis of tumors in these areas.

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  • (PMID = 16883493.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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93. Nishi SP, Brey NV, Sanchez RL: Dermal nodular fasciitis: three case reports of the head and neck and literature review. J Cutan Pathol; 2006 May;33(5):378-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermal nodular fasciitis: three case reports of the head and neck and literature review.
  • Nodular fasciitis is a benign reactive myofibroblastic proliferative process of unknown etiology.
  • Diagnosis is often a challenge because it may be confused with a malignant tumor due to its aggressive clinical behavior and histological features.
  • Although most commonly located on the extremities and then the trunk, it is estimated that the head and neck region represents only 10 to 20%.
  • Interestingly, cases in the head and neck region often involve dermal tissue.
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Head and Neck Neoplasms / pathology. Humans. Immunohistochemistry. Male. Skin Neoplasms / pathology

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  • (PMID = 16640547.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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94. Wang D, Chen S, Feng Y, Yang Q, Campbell BH, Tang X, Campbell WB: Reduced expression of 15-lipoxygenase 2 in human head and neck carcinomas. Tumour Biol; 2006;27(5):261-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reduced expression of 15-lipoxygenase 2 in human head and neck carcinomas.
  • In the present study, we report a significant reduction of 15-lipoxygenase 2 (15-LOX-2) in seven carcinoma cell lines of the human head and neck when compared with normal primary cultured keratinocytes, and 18 primary head and neck squamous cell carcinomas (HNSCC) when compared with matched normal mucosa.
  • 15-LOX-2 is mainly expressed in the mature cells of the benign squamous epithelium, but not in the basal layer cells of benign epithelium, suggesting a role of 15-LOX-2 in cell differentiation.
  • Our results demonstrate that 15-LOX-2 expression is significantly reduced and this reduction may promote proliferation in human head and neck carcinoma.
  • 15-LOX-2 may be a possible biomarker in human head and neck malignancy.
  • [MeSH-major] Arachidonate 15-Lipoxygenase / metabolism. Carcinoma / enzymology. Head and Neck Neoplasms / enzymology
  • [MeSH-minor] Carcinoma, Squamous Cell. Cell Proliferation. Cells, Cultured. Gene Expression Regulation, Enzymologic. Humans. Keratinocytes / enzymology. Nitrobenzenes / pharmacology. Sulfonamides / pharmacology. Tumor Cells, Cultured

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16874012.001).
  • [ISSN] 1010-4283
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-37981
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.13.11.33 / ALOX15B protein, human; EC 1.13.11.33 / Arachidonate 15-Lipoxygenase
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95. Ferris RL, Branstetter BF, Nayak JV: Diagnostic utility of positron emission tomography-computed tomography for predicting malignancy in cystic neck masses in adults. Laryngoscope; 2005 Nov;115(11):1979-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic utility of positron emission tomography-computed tomography for predicting malignancy in cystic neck masses in adults.
  • OBJECTIVES: Combined positron emission tomography and computed tomography (PET-CT) is used for the diagnostic evaluation and staging of squamous cell carcinoma of the head and neck (SCCHN).
  • Because the diagnostic algorithm for cystic neck masses in adults often overlaps with the work-up of cancer of unknown primary site, we evaluated the utility of PET-CT scans to identify the presence of malignancy and the location of primary tumor.
  • METHODS: We reviewed the PET-CT imaging of cystic neck masses occurring in five patients over 40 years of age with significant risk factors for SCCHN and correlated this information with histopathology.
  • Ultimately, clinical judgment and endoscopic evaluation, guided by CT findings, were most valuable for distinguishing malignant versus benign processes and identifying the primary tumor sites.
  • CONCLUSIONS: PET-CT may not be a reliable modality for identifying malignancy in adults with suspicious cystic neck masses.
  • A thorough clinical evaluation by an experienced head and neck surgeon, in conjunction with contrast-enhanced CT, may be sufficient to facilitate the optimal management of such patients.
  • [MeSH-major] Cysts / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 16319609.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Stein PJ: A case of cerebellopontine angle meningioma presenting with neck and upper extremity pain. J Manipulative Physiol Ther; 2009 Nov-Dec;32(9):776-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of cerebellopontine angle meningioma presenting with neck and upper extremity pain.
  • CLINICAL FEATURES: A 29-year-old man presented to a chiropractor with diffuse musculoskeletal pain in the neck and right upper extremity.
  • INTERVENTION AND OUTCOME: Magnetic resonance imaging studies of the neck and brain revealed a posterior fossa tumor, which was eventually diagnosed as a benign meningioma.
  • Partial surgical removal of the tumor mass was followed by radiation therapy.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / radiography. Cerebellopontine Angle / pathology. Cerebellopontine Angle / radiography. Meningioma / pathology. Meningioma / radiography. Neck / physiopathology. Pain / etiology. Pain / physiopathology. Upper Extremity / physiopathology

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  • (PMID = 20004806.001).
  • [ISSN] 1532-6586
  • [Journal-full-title] Journal of manipulative and physiological therapeutics
  • [ISO-abbreviation] J Manipulative Physiol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Brown HM, Cuttino E, LeRoy BE: A subcutaneous mass on the neck of a horse. Vet Clin Pathol; 2007 Mar;36(1):109-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A subcutaneous mass on the neck of a horse.
  • A 25-year-old Arabian gelding was presented for investigation of a subcutaneous neck mass.
  • Strong reactivity of the tumor cells for both Giemsa and toluidine blue stains confirmed the diagnosis of a mast cell tumor, and a Luna stain accentuated the eosinophilic infiltrates.
  • Cutaneous mast cell tumors are found in many domestic animals but are uncommonly encountered in horses.
  • Equine cutaneous mast cell tumors are usually benign, and there are no reports of visceral metastasis.

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  • (PMID = 17311206.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. O'Callaghan MG, House M, Ebay S, Bhadelia R: Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. J Comput Assist Tomogr; 2005 Jan-Feb;29(1):130-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging.
  • A case of fetal rhabdomyoma (myxoid type) of the head and neck demonstrated on prenatal magnetic resonance imaging (MRI) is presented.
  • This benign tumor of skeletal muscle is uncommon and should not be confused with its malignant counterpart-rhabdomyosarcoma.
  • With the increasing use of ultrafast MRI, the radiologist is more likely to encounter head and neck masses in the fetus.
  • [MeSH-major] Fetal Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Magnetic Resonance Imaging. Prenatal Diagnosis. Rhabdomyoma / diagnosis
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Gestational Age. Humans. Infant, Newborn. Neoplasm Recurrence, Local / pathology. Pregnancy. Ultrasonography, Prenatal


99. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • PURPOSE: Emerging technologies allow surgeons to diagnose and treat osseous neoplasms while minimizing the collateral damage caused by surgical exposure and tumor excision.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • METHODS: Stereotactic imaging and intraoperative guidance was used as an adjunct to tumor care in these patients.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • RESULTS: Computer-assisted stereotactic localization allowed us to successfully ablate these lesions from their anatomically challenging locations, without disrupting the shoulder girdle or neck musculature, and without extensive bony resection.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Beier UH, Holtmeier C, Weise JB, Görögh T: Fibronectin suppression in head and neck cancers, inflammatory tissues and the molecular mechanisms potentially involved. Int J Oncol; 2007 Mar;30(3):621-9
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  • [Title] Fibronectin suppression in head and neck cancers, inflammatory tissues and the molecular mechanisms potentially involved.
  • To determine if these findings are unique to malignant processes and to identify mechanisms responsible for fibronectin suppression, we investigated fibronectin expression patterns in 46 head and neck carcinomas, 16 samples of adenoid tissue, and 10 benign mucosal biopsies.
  • We report fibronectin suppression in 78% of the head and neck cancer samples, occurring most prominently within tumor cells, as opposed to the adjacent stroma which exhibited abundant fibronectin.
  • We showed that fibronectin suppression is mediated by different mechanisms in both benign as well as malignant scenarios: In adenoids, macrophages and T-cells were visualized throughout epithelium that has lost its tight cellular array, allowing leukocyte passage.
  • We have shown that tumor necrosis factor-alpha secreted by macrophages is capable of inducing epithelial derangement via activator protein-1 and nuclear factor-kappaB mediated fibronectin suppression.
  • In head and neck carcinomas, we identified human papilloma virus early protein-2 as a fibronectin transcription inhibitor.
  • We conclude that epithelial fibronectin suppression may not be a hallmark of malignancy, because it can concur with benign processes that involve leukocyte migration.
  • Furthermore, our data suggest that the pattern of fibronectin suppression within the tumor structure largely depends on the cancer cell-stroma relation, which could explain previous conflicting reports on its repression or overexpression along with malignant transformation.
  • [MeSH-major] Carcinoma / metabolism. Carcinoma / pathology. Fibronectins / biosynthesis. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Inflammation

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  • (PMID = 17273763.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Fibronectins; 0 / Transcription Factor AP-1
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