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1. Han MW, Lee BJ, Jang YJ, Chung YS: Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses. Otolaryngol Head Neck Surg; 2010 Sep;143(3):341-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cytopathologic and histologic findings were categorized as malignancy, benign neoplasm, or non-neoplastic lesion.
  • We investigated the accuracy of endoscopic incisional biopsy and preoperative imaging by comparing it with pathologic results from tumor resection as the "gold standard."
  • RESULTS: Most of the patients had unilateral nasal symptoms (e.g., nasal obstruction, unilateral epistaxis, unilateral facial pain), and the clinical symptoms were of little diagnostic value in the differentiation of tumor and inflammatory lesion.
  • The sensitivity and specificity of endoscopic incisional biopsy were 43.7 and 98.9 percent, respectively, for the diagnosis of nasal cavity malignancies, and 78.2 and 96.2 percent, respectively, for the diagnosis of benign neoplasms.
  • The sensitivity and specificity of preoperative imaging were 78.3 and 97.5 percent, respectively, for the diagnosis of nasal cavity malignancies and 66.4 and 86.3 percent, respectively, for the diagnosis of benign neoplasms.
  • CONCLUSION: Endoscopic incisional biopsy alone did not ensure accurate diagnosis of nasal cavity tumors, but in combination with preoperative imaging it was helpful for the diagnosis of nasal cavity malignancies.

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20723769.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Zhou YA, Huang JH, Wan CY, Zuo ZB: [Surgical treatment and effect observation of cervical intraspinal benign neoplasms]. Zhongguo Gu Shang; 2009 Nov;22(11):856-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical treatment and effect observation of cervical intraspinal benign neoplasms].
  • OBJECTIVE: To investigate the diagnosis, surgical procedure and clinical outcome of cervical intraspinal benign neoplasm.
  • Symptoms mainly included neck pain, numbness and weakness of the extremities, urinary and fecal incontinence, pyramid signs, etc.
  • The tumors were removed completely in 18 cases, above 60% in 3 cases and 25% with biopsy in 1 case.
  • Cervical stability in 11 cases was restored after removal of tumors.
  • CONCLUSION: The surgical exairesis for cervical intraspinal benign neoplasm has low post-operative recurrence.
  • The main reason of recurrence is not removed the tumor completely.

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  • (PMID = 20084949.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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3. Lew JI, Solorzano CC: Use of ultrasound in the management of thyroid cancer. Oncologist; 2010;15(3):253-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrasound has become useful in the qualitative characterization of thyroid nodules based on benign or malignant features.
  • [MeSH-minor] Biopsy, Needle / methods. Humans. Neoplasm Staging

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  • (PMID = 20215358.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3227957
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4. Ahmadi N, Davison SP, Kauffman CL: Melanocytic nevi with Spitz differentiation: diagnosis and management. Laryngoscope; 2010 Dec;120(12):2385-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Melanocytic proliferations with Spitz differentiation present a difficult clinicopathologic dilemma, as their spectrum ranges from benign to malignant.
  • Their histopathologic differentiation can be challenging, and cases of Spitzoid melanoma initially diagnosed as benign Spitz nevi are reported in the literature.
  • The goal of this article is to discuss the diagnostic tools (including comparative genomic hybridization), which may be helpful in differentiating benign Spitz nevi from malignant melanoma with Spitzoid features, and to propose an appropriate management strategy for each entity.
  • [MeSH-major] Neoplasm Staging / methods. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 21072755.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Iván L, Paczona R, Szentpáli K, Jóri J: Peroral endoscopic removal: as a minimally invasive long-term surgical treatment of a regurgitated giant polisegmented fibrovascular polyp of the esophagus. Eur Arch Otorhinolaryngol; 2009 Jul;266(7):1031-4
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  • Giant fibrovascular polyps (FVP) are relatively rare benign neoplasm of the upper part of the esophagus.

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  • (PMID = 18688632.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Retracted Publication
  • [Publication-country] Germany
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6. Batra PS, Luong A, Kanowitz SJ, Sade B, Lee J, Lanza DC, Citardi MJ: Outcomes of minimally invasive endoscopic resection of anterior skull base neoplasms. Laryngoscope; 2010 Jan;120(1):9-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant and benign tumors were managed in 25 (80.6%) and six (19.4%) cases, respectively.
  • American Joint Committee on Cancer tumor staging was T3N0M0 and T4N0M0 in 14 (56%) and 11 (44%) of the malignant cases, respectively.
  • CONCLUSIONS: This study validated technical feasibility of MIER for diversity of benign and malignant ASB histopathology.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / surgery. Carcinoma, Squamous Cell / surgery. Esthesioneuroblastoma, Olfactory / surgery. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Melanoma / surgery. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19877265.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Yoshino T, Yoneda K: Laparoscopic resection of a retroperitoneal ancient schwannoma: a case report and review of the literature. Anticancer Res; 2008 Sep-Oct;28(5B):2889-91
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  • Schwannomas are benign tumors that arise from neural sheath Schwann cells.
  • Solitary benign schwannomas are generally located in the head and neck, often along the cranial nerves, and are a particularly rare neoplasm among tumors of the retroperitoneal space.
  • The pathological diagnosis was retroperitoneal benign schwannoma consisting of mixture of a Antoni-A and -B type cells.

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  • (PMID = 19031930.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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8. Riggs S, Orlandi RR: Juvenile nasopharyngeal angiofibroma recurrence associated with exogenous testosterone therapy. Head Neck; 2010 Jun;32(6):812-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Juvenile nasopharyngeal angiofibromas (JNAs) are rare benign lesions that express hormonal receptors.
  • Exogenous testosterone can cause tumor regrowth at any time, even decades following treatment.
  • [MeSH-minor] Adult. Cranial Fossa, Posterior / pathology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / surgery. Pterygopalatine Fossa / pathology. Skull Base Neoplasms / pathology. Tomography, X-Ray Computed

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc. Head Neck, 2010.
  • (PMID = 19626637.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone
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9. Jaidane M, Bouicha T, Slama A, Hmida W, Hidoussi A, Ben Sorba N, Mosbah F: Tumor recurrence in prostatic urethra following simultaneous resection of bladder tumor and prostate: a comparative retrospective study. Urology; 2010 Jun;75(6):1392-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor recurrence in prostatic urethra following simultaneous resection of bladder tumor and prostate: a comparative retrospective study.
  • OBJECTIVES: To evaluate the effect on the oncological outcomes and recurrences at the prostatic urethra of simultaneous transurethral resection of bladder tumor (TURBT) and benign prostatic hyperplasia (TURP).
  • Clinicopathologic parameters, recurrence and progression rates, and recurrence rates in the bladder neck and prostatic urethra were determined and compared.
  • At a mean follow-up of 35.2 and 33.1 months in groups 1 and 2, respectively, only 1 patient developed recurrence in prostatic urethra or bladder neck in each group.
  • There were no statistically significant differences between the 2 groups in follow-up time, recurrence, progression or recurrence in the prostatic urethra, and bladder neck.
  • CONCLUSIONS: According to our results, simultaneous transurethral TURP and TURBT can be safely performed without increasing the risk of tumor recurrence in the prostatic urethra.
  • [MeSH-major] Cystectomy / methods. Neoplasm Recurrence, Local / epidemiology. Prostatic Hyperplasia / surgery. Transurethral Resection of Prostate / methods. Urinary Bladder Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Chi-Square Distribution. Cohort Studies. Combined Modality Therapy. Cystoscopy / methods. Follow-Up Studies. Humans. Immunohistochemistry. Incidence. Male. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Postoperative Complications / mortality. Postoperative Complications / pathology. Probability. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Rate. Treatment Outcome. Urethra / surgery

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19781747.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Smith JA, Fan CY, Zou C, Bodenner D, Kokoska MS: Methylation status of genes in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg; 2007 Oct;133(10):1006-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To determine the methylation status of gene promoter regions using methylation-specific polymerase chain reaction in genes encoding for thyrotropin receptor (TSHR), E-cadherin (ECAD), sodium iodide symporter protein (NIS-L), ataxia telangiectasia mutated (ATM), and death-associated protein kinase (DAPK) proteins and if methylation status correlates with patient variables, tumor factors, or outcome measures among patients with papillary thyroid carcinoma.
  • Methylation status was then compared with patient variables, tumor factors, and outcome measures for patients with thyroid carcinoma and controls.
  • NIS-L methylation in cancer cells was not associated with methylation in adjacent benign tissue, unlike the other 4 genes.
  • Neither age nor sex affected methylation status, and methylation status did not correlate with extent of the primary tumor or presence of nodal metastasis at diagnosis.
  • Tumors recurred less frequently in patients with TSHR methylation than in patients with unmethylated TSHR promoter regions.
  • Furthermore, methylation status of tumors as determined by methylation-specific polymerase chain reaction may help in determining patient prognosis.
  • [MeSH-major] Carcinoma, Papillary / genetics. DNA, Neoplasm / genetics. Receptors, Thyrotropin / metabolism. Symporters / metabolism. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Humans. Iodine. Male. Methylation. Middle Aged. Polymerase Chain Reaction. Prognosis. Promoter Regions, Genetic / physiology. Retrospective Studies

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  • (PMID = 17938324.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Receptors, Thyrotropin; 0 / Symporters; 0 / sodium-iodide symporter; 9679TC07X4 / Iodine
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11. Zhang J, Ji J, Yuan F, Chen J, Yan M, Yu YY, Liu BY, Yin HR, Lin YZ, Zhu ZG: [Transcription factor Sp1 expression in gastric cancer and its prognostic value]. Zhonghua Zhong Liu Za Zhi; 2005 Sep;27(9):531-3
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  • METHODS: By using immunohistochemistry, we studied the Sp1 expression patterns in 65 cases of gastric cancer with various clinico-pathologic characteristics, and 40 normal gastric mucosa specimens obtained from patients who underwent partial gastrectomy for benign gastric diseases.
  • The positively stained glandular cells were mainly limited to those in the neck region.
  • The medium survival time in patients who had a tumor with negative, weak and strong Sp1 expression was 1700, 1560 and 1026 days, respectively (P = 0.036).
  • Sp1 protein expression was closely related to the depth of tumor invasion and TNM stage (P = 0.001, P = 0.026), but not related to the number of metastatic lymph nodes and Lauren's classification (P = 0.306, P = 0.667).
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / biosynthesis. Sp1 Transcription Factor / biosynthesis. Stomach Neoplasms / metabolism
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Gastric Mucosa / metabolism. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis

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  • (PMID = 16438849.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Sp1 Transcription Factor
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12. Watanabe H, Ishida Y, Nagashima K, Makino T, Norisugi O, Shimizu T: Desmoplastic fibroblastoma (collagenous fibroma). J Dermatol; 2008 Feb;35(2):93-7
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  • Desmoplastic fibroblastoma (DF) is a rare fibrotic tumor that has a wide anatomic distribution and it can appear in deep sections of the subcutis, in fascia, in aponeurosis or in skeletal muscles.
  • This report describes a case of DF that appeared on the left side of the neck of a 55-year-old male as a 3.5-cm solitary, firm nodule.
  • The entrapment of fat and muscle tissues was focally identified at the edges of the tumor.
  • These findings suggest that the stellate and multinucleated cells in the lesion were of fibroblastic origin and this neoplasm was pathologically benign.
  • [MeSH-major] Fibroma / pathology. Head and Neck Neoplasms / pathology

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  • (PMID = 18271804.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Goshen E, Davidson T, Yahalom R, Talmi YP, Zwas ST: PET/CT in the evaluation of patients with squamous cell cancer of the head and neck. Int J Oral Maxillofac Surg; 2006 Apr;35(4):332-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PET/CT in the evaluation of patients with squamous cell cancer of the head and neck.
  • The purpose of this study was to compare the findings of positron emission tomography (PET) with fused PET and computed tomography (CT) in patients with suspected locoregional and distant head and neck cancer and to evaluate the impact of those findings on clinical management.
  • PET findings were classified as malignant, benign or equivocal.
  • The negative predictive value was 100% in this combined group of patients with locoregional and distant head and neck cancer.
  • PET/CT is highly contributory for initial staging and in the evaluation of patients with suspected recurrent SCC of the head and neck, in whom anatomic imaging is inconclusive due to the locoregional distortions rendered by surgery and radiotherapy.
  • [MeSH-major] Head and Neck Neoplasms / radiography. Head and Neck Neoplasms / radionuclide imaging. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 16280234.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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14. Rego A, Amado J, Esteves I, Almeida J, Furtado A, Couceiro A, Moura e Sá J: [Endobronchial granular cell tumor - what approach to take]. Rev Port Pneumol; 2006 Jul-Aug;12(4):463-70
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  • [Title] [Endobronchial granular cell tumor - what approach to take].
  • [Transliterated title] Tumor de células granulares endobrônquico - Como abordamos?
  • Granular cell tumor is a mesenchymal neoplasm almost always benign, with tendency to recurrence.
  • Although it is more frequent in in the head and neck it has been described in almost all areas of the body.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / therapy. Granular Cell Tumor / diagnosis. Granular Cell Tumor / therapy

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  • (PMID = 16969575.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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15. Dutsch-Wicherek M, Tomaszewska R, Strek P, Wicherek L, Skladzien J: The analysis of RCAS1 and DFF-45 expression in nasal polyps with respect to immune cells infiltration. BMC Immunol; 2006 Mar 21;7:4
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  • BACKGROUND: Nasal polyp constitutes a benign growth process in the nasal and sinus mucosa.

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  • (PMID = 16551346.001).
  • [ISSN] 1471-2172
  • [Journal-full-title] BMC immunology
  • [ISO-abbreviation] BMC Immunol.
  • [Language] ENG
  • [Grant] United Kingdom / Wellcome Trust / / WL/ZKL/26/L
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA fragmentation factor, human; 0 / EBAG9 protein, human; 0 / Proteins
  • [Other-IDs] NLM/ PMC1448183
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16. Wang CP, Lee YC, Lou PJ, Yang TL, Chen TC, Huang CC, Ko JY: Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer. Oral Oncol; 2009 Jul;45(7):615-20
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  • [Title] Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer.
  • Dysphagia is not uncommon after curative treatment for primary head and neck cancer.
  • The purpose of this study was to prospectively investigate the diagnostic value of unsedated transnasal esophagogastroduodenoscopy (EGD) in 36 primary head and neck cancer patients with post-treatment dysphagia.
  • Except three patients with very narrow space or the presence of the tumor in the neopharynx, transnasal EGD could completely evaluate the upper digestive tract in 33 patients and found one patient with local recurrent hypopharyngeal cancer, seven patients with newly diagnosed hypopharyngeal cancer, four patients with esophageal cancer, and one patient with simultaneous hypopharyngeal and esophageal cancers, which were all successfully biopsied and proven microscopically.
  • One patient had a benign tumor on the epiglottis and the other NPC patient had extensive soft tissue necrosis in the pyriform sinus as a cause of dysphagia.
  • The present study indicates that unsedated transnasal EGD is feasible to confidently distinguish between functionally/anatomically-related dysphagia and newly growing tumors in the upper digestive tract, and to obtain biopsy specimens for pathological diagnosis from the tumors in a single session.
  • [MeSH-major] Deglutition Disorders / diagnosis. Endoscopy, Digestive System / methods. Esophageal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Conscious Sedation. Feasibility Studies. Female. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Prospective Studies. Taiwan

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  • (PMID = 19027351.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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17. Sandison A: Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma. Head Neck Pathol; 2009 Sep;3(3):260-2
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  • [Title] Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma.
  • The most common diagnostic dilemma for pathologists referring cases for second opinion is the recognition of low grade malignancy versus benign inverted papilloma at presentation and in lesions which recur.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Papilloma, Inverted / pathology
  • [MeSH-minor] Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Humans. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 20596982.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
  • [Other-IDs] NLM/ PMC2811634
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18. Ahn JY, Kang SY, Lee CH, Yoon PH, Lee KS: Parapharyngeal branchial cleft cyst extending to the skull base: a lateral transzygomatic-transtemporal approach to the parapharyngeal space. Neurosurg Rev; 2005 Jan;28(1):73-6
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  • Second BCCs usually lie on the great vessels of the neck, deep in the sternocleoidomastoid muscle or along its anterior border at the mandibular angle.
  • Parapharyngeal second BCCs are an uncommon neoplasm and rarely extend to the skull base.
  • We conclude the lateral transzygomatic-transtemporal approach allows surgeons direct access to the parapharyngeal space with satisfactory exposure for treating benign lesions of the parapharyngeal space.
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness. Skull Base / pathology. Skull Base / surgery. Temporal Bone / surgery. Zygoma / surgery

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  • [Language] eng
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19. Sim J, Kim H, Lee H, Ahn K, Lee SI: Etiology of hemoptysis in children: a single institutional series of 40 cases. Allergy Asthma Immunol Res; 2009 Oct;1(1):41-4
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  • Other causes included congenital heart disease, Heiner syndrome, neoplasm in the airway, vasculitis syndrome, and bronchiectasis.
  • Most cases had a benign course, but recurrence and mortality occurred in a minority of patients.

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  • (PMID = 20224669.001).
  • [ISSN] 2092-7363
  • [Journal-full-title] Allergy, asthma & immunology research
  • [ISO-abbreviation] Allergy Asthma Immunol Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2831566
  • [Keywords] NOTNLM ; children / etiology / hemoptysis
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20. Durgun Y, Firat C, Miman MC, Kirimlioglu H: A rare benign laryngeal tumor: angiomyolipoma. J Craniofac Surg; 2010 Nov;21(6):1956-7
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  • [Title] A rare benign laryngeal tumor: angiomyolipoma.
  • Angiomyolipoma is a mesenchymal neoplasm containing adipose tissue, blood vessels, and smooth muscle fibers.
  • Arising most frequently in the kidney, the tumor may exceptionally be at the head and neck region.
  • The tumor was removed by an endolaryngeal approach.

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  • (PMID = 21119467.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations.
  • Sites of involvement included the omentum or mesentery (6 cases), uterus (4 cases), pelvic soft tissues (3 cases), abdominal wall (2 cases), uterine cervix (2 cases), and vagina, retroperitoneum, thigh, falciform ligament, scalp, broad ligament, forearm, shoulder, and neck (1 case each).
  • The tumors ranged from 1.6 to 29 cm in size (median, 7.8 cm).
  • Tumors were epithelioid (N = 9), spindled (N = 7), or mixed (N = 10).
  • Recurrence and/or metastasis was strongly associated tumor size > median size (8 cm), mitotic activity greater than 1/50 HPF, and necrosis.
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Connective and Soft Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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22. Mirza S, Bradley PJ, Acharya A, Stacey M, Jones NS: Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. J Laryngol Otol; 2007 Sep;121(9):857-64
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  • INTRODUCTION: Inverted papillomas are relatively rare, benign epithelial tumours of the nasal cavity which generate considerable interest because they are locally aggressive, have a tendency to recur and are associated with malignancy.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Papilloma, Inverted / epidemiology. Paranasal Sinus Neoplasms / epidemiology

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  • (PMID = 17319993.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 69
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23. de Leeuw J, van der Beek N, Neugebauer WD, Bjerring P, Neumann HA: Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage. Lasers Surg Med; 2009 Feb;41(2):96-103
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  • OBJECTIVE: The purpose of the present study was to use a large area skin fluorescence detection system to detect early NMSCs (clinical visible as well as non-visible lesions) in the face, neck, chest, back and hands of patients treated with UV and outdoor workers.
  • After histological examination the positive fluorescence appeared to be correlated to benign lesions in 28 patients (sebaceous gland hyperplasia in 22 patients) and to (pre-) malignant lesions in 33 patients (actinic keratosis in 29, BCC in 3 and SCC in 1 patient).
  • [MeSH-minor] Aminolevulinic Acid. Female. Fluorescence. Humans. Liposomes. Male. Middle Aged. Neoplasm Staging. Photosensitizing Agents

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19226578.001).
  • [ISSN] 1096-9101
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Liposomes; 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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24. Arshad AR, Azman WS, Kreetharan A: Solitary sebaceous nevus of Jadassohn complicated by squamous cell carcinoma and basal cell carcinoma. Head Neck; 2008 Apr;30(4):544-8
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  • BACKGROUND: Sebaceous nevus is a benign congenital epidermal nevus.
  • RESULTS: The behavior of this tumor is very aggressive, resulting in poor prognosis.
  • [MeSH-minor] Fatal Outcome. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Surgical Flaps


25. Chiesa F, Tradati N, Grigolato R, Boracchi P, Biganzoli E, Crose N, Cavadini E, Formelli F, Costa L, Giardini R, Zurrida S, Costa A, De Palo G, Veronesi U: Randomized trial of fenretinide (4-HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: long-term results. Int J Cancer; 2005 Jul 1;115(4):625-9
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  • In a controlled multicenter study, 170 patients operated on for oral leukoplakias with benign postoperative histology were randomized to 200 mg fenretinide daily for 1 year vs. no intervention.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma / prevention & control. Fenretinide / therapeutic use. Leukoplakia, Oral / drug therapy. Mouth Neoplasms / drug therapy. Neoplasm Recurrence, Local / prevention & control

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15700313.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 187EJ7QEXL / Fenretinide
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26. Christein JD, Smoot RL, Farnell MB: Central pancreatectomy: a technique for the resection of pancreatic neck lesions. Arch Surg; 2006 Mar;141(3):293-9
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  • [Title] Central pancreatectomy: a technique for the resection of pancreatic neck lesions.
  • Although historically used for traumatic pancreatic transection and chronic pancreatitis, it currently is reserved for selective management of pancreatic neck lesions that are benign or have low malignant potential.
  • Our objectives were to describe the technique and determine the safety and effectiveness of central pancreatectomy in the excision of benign or low-malignant potential lesions of the pancreatic neck.
  • INTERVENTION: Patients with pancreatic neck or proximal body masses underwent central pancreatectomy at the Mayo Clinic, Rochester, Minn.
  • RESULTS: Abnormalities included 3 islet cell tumors, 2 serous cystadenomas, a mucinous cystadenoma, a lymphoepithelial cyst, and a recurrent liposarcoma.
  • Mean tumor size was 2.8 cm and mean operative time was 4.8 hours with a mean blood loss of 381 mL.
  • Caution is necessary when using central pancreatectomy in the treatment of pancreatic neck lesions.
  • The precise role of central pancreatectomy in the management of benign or low-malignant potential lesions of the neck of the pancreas remains in evolution.
  • [MeSH-minor] Adenoma, Islet Cell / radiography. Adenoma, Islet Cell / surgery. Cystadenoma, Serous / radiography. Cystadenoma, Serous / surgery. Female. Humans. Liposarcoma / surgery. Male. Mesenteric Veins / surgery. Middle Aged. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16549696.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Patsiaoura K, Anagnostou E, Benis N: Intramuscular myxoma of the nasal vestibule. Auris Nasus Larynx; 2010 Feb;37(1):100-2
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  • Intramuscular myxoma is an uncommon benign soft tissue neoplasm and a distinct histopathological entity within the heterogeneous group of myxomas.
  • The tumor was surgically removed and the patient is free of recurrence or complications 8 months after treatment.
  • The head and neck region is an uncommon site of presentation for intramuscular myxoma with only 13 documented cases in the available literature.
  • To the very best of our knowledge, there is no report of this neoplasm located within the nasal and oral mimetic muscles.

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19414229.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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28. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • Mean tumor size was 1.1 cm (range: 0.3 to 6 cm; 90% <2 cm).
  • The tumors arose most often on the upper limb (35%) or head and neck (33%).
  • Fifty-two percent of the tumors were limited to the dermis, and 48% also involved superficial subcutaneous tissue.
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Nearly all tumors had a lobulated or micronodular architecture and were composed of nests and bundles of epithelioid to spindled cells with palely eosinophilic cytoplasm, often separated by dense hyaline collagen; 17 (13%) showed focally sheetlike areas, and 5 (4%) were notably plexiform.
  • Myxoid stroma was observed in 38 (29%) tumors; 11 (8%) were predominantly myxoid.
  • Most tumors showed mild cytologic atypia in the form of nuclear variability and small nucleoli; 33 (25%) contained notably pleomorphic cells.
  • All tumors were reactive for NKI-C3, 110/123 (89%) expressed neuron-specific enolase, 73/127 (57%) showed at least focal staining for smooth muscle actin, and only 1 was focally desmin positive.
  • All tumors were negative for S-100 protein.
  • Ten tumors recurred locally (7 situated on the face), after a mean of 18 months; tumor had been marginally excised or had involved excision margins in all cases with available information.
  • Cellular neurothekeomas have a predilection for the upper limbs and head and neck of pediatric and young adult females and rarely recur following incomplete excision.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Oxenius I, Vacirca F: [A rare case of fibroepithelial polyp of the proximal urethra in a young woman]. Urologia; 2008 Jul-Sep;75(3):193-4
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  • Fibroepithelial polyps are benign epithelial tumours which are rare in adults.
  • We report a case of a twenty-seven-year-old woman, presenting with painless terminal gross haematuria, affected by a neoplasm located in the proximal urethra near the bladder neck.
  • Endoscopic image of the tumour and histopatological details are shown.

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  • (PMID = 21086351.001).
  • [ISSN] 0391-5603
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] United States
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30. Betka J, Chovanec M, Klozar J, Taudy M, Plzák J, Kodetová D, Lisý J: Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors. Eur Arch Otorhinolaryngol; 2010 May;267(5):765-72
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  • [Title] Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors.
  • The goal of parapharyngeal space (PPS) tumor surgery is to obtain adequate visualization to ensure complete removal with preservation of the surrounding nerves and vessels.
  • Transoral approach is the most controversial one due to cited limited exposure, risk of tumor spillage, and possibility of neurovascular injury.
  • We performed retrospective analysis of 26 consecutive patients who had undergone transoral or combined transoral-transcervical resection of PPS tumors from January 1997 to December 2007.
  • Both approaches were safely employed to remove selected PPS tumors.
  • Majority of treated tumors were pleomorphic adenomas (14 minor salivary gland and 7 deep lobe parotid gland tumors).
  • Two cases of malignant salivary gland tumors, 4 nerve sheath tumors and 1 lymphangioma were also excised.
  • Mean tumor size was 6.1 cm (range 2-11 cm).
  • Patients with malignant tumors had postoperative radiotherapy.
  • One of the near-totally resected tumors needed revision surgery.
  • Transoral approach provides access to selected cases of PPS tumors based on preoperative imaging methods and fine-needle aspiration cytology.
  • It can be combined with external approach to achieve safe resection of some benign tumors which would need transmandibular approach.
  • [MeSH-minor] Female. Humans. Male. Mouth. Neck. Neoplasm Staging. Nerve Sheath Neoplasms / surgery. Salivary Gland Neoplasms / surgery

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  • [Cites] Radiology. 1988 Oct;169(1):81-5 [2843942.001]
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  • (PMID = 19714351.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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31. Schaller B: Spinal meningioma: relationship between histological subtypes and surgical outcome? J Neurooncol; 2005 Nov;75(2):157-61
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  • Intraspinal meningiomas are slow growing benign tumors that produce indolent neurological deficits, which are often reversible following operation.
  • Tumor position was laterally in 19 (58%), posteriorly in 8 (24%) and anteriorly in 6 (18%) patients.
  • Following tumor resection, neurological deficits resolved in 26 of 33 patients (79%) and worsened in 7 of 33 patients (21%) all of the latter had meningiomas of the psammomatous type.
  • Posterior or lateral tumor position in the spinal canal, location below C4, age less than 60 years, and duration of preoperative symptoms seem to be correlated with a good outcome.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Angiography. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Myelography. Neoplasm Recurrence, Local. Neurologic Examination. Prognosis. Regression Analysis. Retrospective Studies. Sex Factors. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Tumor Burden. X-Rays

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  • [Cites] J Neuropathol Exp Neurol. 2002 Mar;61(3):215-25; discussion 226-9 [11895036.001]
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  • (PMID = 16132511.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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32. Park YJ, Kim YA, Lee YJ, Kim SH, Park SY, Kim KW, Chung JK, Youn YK, Kim KH, Park DJ, Cho BY: Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings. Head Neck; 2010 Jan;32(1):38-45
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  • BACKGROUND: Papillary thyroid microcarcinoma (PMC; <or=1 cm) is thought to take a benign course during the lifetime.
  • Immunohistochemical staining showed no different expression pattern according to the tumor size.
  • [MeSH-minor] Adult. DNA Mutational Analysis. Disease Progression. Female. Follow-Up Studies. Genetic Markers / genetics. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prevalence. Republic of Korea / epidemiology. Retrospective Studies

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  • (PMID = 19475551.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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33. Seper L, Schwab R, Kiattavorncharoen S, Büchter A, Bánkfalvi A, Joos U, Piffkó J, Kruse-Loesler B: Malignant fibrous histiocytoma of the face: report of a case. Head Face Med; 2007;3:36
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  • BACKGROUND: Soft tissue sarcomas in the head and neck region are rare and often present a difficult differential diagnosis.
  • Four months beforehand, a benign fibrous histiocytoma (BFH) had been removed from the same location by excision biopsy with wide tumour-free resection margins.
  • Radical tumour resection was completed by extended parotidectomy and neck dissection; the skin defect was covered by a regional bi-lobed flap.
  • [MeSH-major] Facial Neoplasms / pathology. Facial Neoplasms / surgery. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / surgery. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neck Dissection / methods. Neoplasm Staging. Reconstructive Surgical Procedures / methods. Risk Assessment. Treatment Outcome

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  • (PMID = 17945018.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2211745
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34. Türköz HK, Oksüz H, Yurdakul Z, Ozcan D: Galectin-3 expression in tumor progression and metastasis of papillary thyroid carcinoma. Endocr Pathol; 2008;19(2):92-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Galectin-3 expression in tumor progression and metastasis of papillary thyroid carcinoma.
  • Galectin-3 expression has been evaluated in various malignant neoplasms to determine its effectiveness in differential diagnosis from benign lesions and its effects on carcinogenesis.
  • We studied the presence of galectin-3 expression immunohistochemically and its relation with tumor invasiveness and lymph node metastasis in 89 cases of papillary carcinoma of the thyroid.
  • Degree of galectin-3 overexpression was also lower in larger tumors (P = 0.009).
  • Additionally, a decreased level of galectin-3 overexpression was observed at the invasive edges of the tumors (P = 0.001).
  • Galectin-3 overexpression is more profound in early stages of papillary carcinoma, and its expression intensity decreases during tumor progression.
  • This finding is consistent with roles for galectin-3 in cell adhesion to other tumor cells and the matrix.
  • [MeSH-minor] Adult. Aged. Aging / pathology. Biomarkers, Tumor. Disease Progression. Female. Humans. Immunohistochemistry. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Metastasis / pathology. Paraffin Embedding. Retrospective Studies. Thyroidectomy

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  • (PMID = 18581271.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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35. Lincoln DT, Singal PK, Al-Banaw A: Growth hormone in vascular pathology: neovascularization and expression of receptors is associated with cellular proliferation. Anticancer Res; 2007 Nov-Dec;27(6B):4201-18
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  • Several growth factors, including basic fibroblast growth factor, transforming growth factors and vascular endothelial growth factor, play a role in tumour angiogenesis.
  • Essential to the initiation of a cellular response to GH, the presence of receptors for this hormone may predict the adaptation of tumour cells resulting from GH exposure.
  • A total of 64 benign and malignant vascular tumours were obtained from different human organ sites, including the chest wall, skin, axillary contents, duodenum, female breast, abdomen, stomach, colon, lymph node, bladder, body flank and neck regions.
  • To delineate tumour cell growth, immunohistochemical analysis of cycling nuclear protein and of proliferating cell nuclear antigen, using Ki-67 and PCNA polyclonal antibodies respectively, was used to demonstrate proliferative indexes.
  • The presence of GHR in endothelial cells of vascular neoplasm indicates that they are target cells and GH is of importance in the proliferation of vascular tumour angiogenesis.
  • The results support the hypothesis that GH is involved in the paracrine-autocrine mechanism, acting locally in regulating vascular tumour growth and will be useful for site-specific studies of the evolution of vascular cancers.
  • The use of anti-GHR antibodies to block tumour progression is an intriguing possibility.

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  • [ErratumIn] Anticancer Res. 2008 Mar-Apr;28(2b):1439
  • (PMID = 18225592.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Receptors, Somatotropin; 9002-72-6 / Growth Hormone
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36. Shaw CK, Sood S, Bradley PJ, Krishnan S: Unusual mass in the parapharyngeal space: a Warthin's tumour. ANZ J Surg; 2006 Mar;76(3):193-4
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  • [Title] Unusual mass in the parapharyngeal space: a Warthin's tumour.
  • Warthin's tumour, another benign salivary tumour involving the PPS has been rarely reported.
  • A case of bilateral, metachronous Warthin's tumour involving the PPS is reported here.
  • PPS Warthin's tumour is a very rare condition that if undiagnosed may result in considerable morbidity.
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Invasiveness. Parotid Gland / surgery. Tomography, X-Ray Computed

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  • (PMID = 16626365.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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37. Belcadhi M, Mani R, Harzallah M, Bouaouina N, Bouzouita K: [Nasopharyngeal angiofibroma with intracranial extension: situating the chemotherapy-radiotherapy association]. Cancer Radiother; 2008 Sep;12(5):385-8
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  • Nasopharyngeal angiofibroma is a locally aggressive, although histologically benign, vascular neoplasm.
  • This neoplasm accounts for 0.05% of head and neck tumours and affects almost exclusively male adolescents.
  • We discuss the relevance and outcome of the association chemotherapy-radiotherapy in the treatment of nasopharyngeal angiofibromas with a consistent intracranial extension (stage III B of Arch Otolaryngol Head Neck Surg 122 (2003) 122-129).
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 18339570.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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38. Ayers LS, Depasquale K, Marlowe FI, Ghaderi M: Pleomorphic adenoma of the external auditory canal: a case report and review of the literature. Ear Nose Throat J; 2010 Mar;89(3):E1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenomas of the external auditory canal (EAC) are benign tumors of the ceruminal glands; they are a rare entity.
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 20229463.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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39. Levy Bencheton A, Mallet S, Rojat Habib MC, Figarella-Branger D, Sigaudy S, Grob JJ, Richard MA: [Isolated late-onset plexiform neurofibroma in the absence of neurofibromatosis]. Ann Dermatol Venereol; 2010 Apr;137(4):301-4
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  • BACKGROUND: Plexiform neurofibroma (NFP) is a benign nervous tumour typically involving the head and neck region due to the rich innervation of the latter.
  • This report describes an unusual case of neurofibroma and discusses its singular presentation, namely an isolated cutaneous tumour of late onset and with myofibroblastic histology.
  • DISCUSSION: This case is original in terms of its characteristics: a single cutaneous tumour of late onset in a patient with no stigmata of NF1 (in most cases of plexiform neurofibroma, NF1 is either multiple or else isolated at a mucous site).
  • The histological findings for this tumour with a myofibroblastic component have never previously been described.
  • Plexiform neurofibroma classically involves the head-and-neck region as in our case, with deep invasion of subcutaneous tissues making excision difficult and leading to frequent recurrence.
  • [MeSH-minor] Age of Onset. Aged, 80 and over. Diagnostic Errors. Fibroblasts / pathology. Humans. Male. Myoblasts / pathology. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neuroma / diagnosis. Postoperative Complications / diagnosis. Reoperation. Subcutaneous Tissue / pathology. Surgical Flaps

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  • [Copyright] 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20417366.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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40. Tysome JR, Chandra A, Chang F, Puwanarajah P, Elliott M, Caroll P, Powrie J, Hubbard JG, Clarke SE, Jeannon JP, Simo R: Improving prediction of malignancy of cytologically indeterminate thyroid nodules. Br J Surg; 2009 Dec;96(12):1400-5
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  • They were reclassified as Thy 3A (probable follicular neoplasm) or Thy 3B (probable non-neoplastic lesion), and subsequently correlated with final clinical outcome to determine the predictive value of this subclassification.
  • If Thy 3A were to predict malignancy and Thy 3B benign disease, the sensitivity of the classification was 88 per cent, with a specificity of 55 per cent and negative predictive value of 91 per cent.

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  • [Copyright] Copyright (c) 2009 British Journal of Surgery Society Ltd.
  • (PMID = 19918854.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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41. Roarke MC, Nguyen BD: Fat hypertrophy in a pharyngeal reconstruction flap presenting as an enlarging neck mass: demonstration of benign changes with PET/CT. Clin Nucl Med; 2006 Jan;31(1):48-9
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  • [Title] Fat hypertrophy in a pharyngeal reconstruction flap presenting as an enlarging neck mass: demonstration of benign changes with PET/CT.
  • The patient is a 73-year-old man with a history of radioresistant recurrent squamous cell carcinoma of the larynx, treated with total laryngectomy/pharyngectomy and rectus abdominis deep inferior epigastric perforator flap reconstruction, who presented with a painless enlarging neck mass.
  • Physical examination revealed increased neck bulk and fiberoptic nasopharyngolaryngoscopy was negative.
  • The clinician was concerned about underlying recurrent neoplasm or adenopathy displacing the flap outward and referred the patient for PET/CT.


42. Bisdas S, Baghi M, Huebner F, Mueller C, Knecht R, Vorbuchner M, Ruff J, Gstoettner W, Vogl TJ: In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck. Eur Radiol; 2007 Jan;17(1):251-7
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  • [Title] In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck.
  • Benign and malignant neoplasms as well as metastatic lymph nodes of 39 patients were examined using localized single voxel magnetic resonance spectroscopy (MRS) [repetition time (TR) 1500, echo time (TE) 135) at 1.5 T.
  • The Cho/Cr ratios in all malignant neoplasms (mean: 5.2, range: 1.7-17.8) were significantly elevated relative to those in the normal muscle structures (mean: 0.9, range: 0.2-1.4), while those in the benign neoplasms were elevated (mean: 24.4, range: 1.4-59.7) with respect to those in the malignant ones.
  • The average Cho/Cr ratio in the metastatic lymph nodes was significantly higher (mean: 4.8, range: 3.3-5.6) than that for benign lymphoid hyperplasia (mean: 2.2, range: 1.0-3.0).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Magnetic Resonance Spectroscopy. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 16703309.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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43. Simonetti S, Mignogna C, La Mantia V, Lanza F, Insabato L: Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report. Tumori; 2009 Jan-Feb;95(1):101-3
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  • Intraosseous cavernomas are very rare benign lesions representing less than 1% of all skeletal tumors and most frequently observed in vertebrae and head and neck bones.
  • We report a case of this neoplasm in the distal epiphysis of the third metacarpal bone in a 68-year-old man, along with the clinicopathological findings.

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  • (PMID = 19366066.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Otoh EC, Johnson NW, Olasoji H, Danfillo IS, Adeleke OA: Salivary gland neoplasms in Maiduguri, north-eastern Nigeria. Oral Dis; 2005 Nov;11(6):386-91
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  • OBJECTIVE: To document the pattern of salivary gland neoplasia in Maiduguri, Nigeria.
  • RESULTS: The palatal (71.9%) and parotid (78.3%) glands were the most common minor and major salivary glands involved, with a benign-malignant ratio of 1:1 and 1.4:1, respectively.
  • Pleomorphic adenoma (44.3%) was the most common salivary gland neoplasm recorded.
  • Ectopic lesions (17.1%) were reported in the neck, nose and cervical nodes.
  • CONCLUSION: Pleomorphic adenoma and mucoepidermoid carcinoma were the most commonly reported benign and malignant neoplasia in this series.

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  • (PMID = 16269031.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 30
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45. Murphy JT, Chandran A, Strachan DR, Sood S: Bilateral inverted papilloma: A report of two cases and review of the current literature. Indian J Otolaryngol Head Neck Surg; 2010 Sep;62(3):313-6
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  • Inverted papilloma is locally aggressive tumour which typically presents as a unilateral nasal polyp.
  • Whilst it has a malignant potential it rarely transforms and in its benign form the main concern originates from its locally aggressive nature and substantial propensity to recur.
  • Bilateral disease can also be due to inverted papilloma, sometimes due to direct extension of the tumour, but it can also occur as two distinct lesions.
  • Here we report two cases of bilateral involvement, review the current literature and highlight some important issues on the management and follow-up of this well known neoplasm.

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  • (PMID = 23120732.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450237
  • [Keywords] NOTNLM ; Bilateral / Inverted papilloma / Paranasal sinus neoplasm
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46. Ahmad R, Ishlah W, Azilah N, Rahman JA: Surgical management of juvenile nasopharyngeal angiofibroma without angiographic embolization. Asian J Surg; 2008 Oct;31(4):174-8
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm that occurs almost exclusively in the nasopharynx of adolescent males.
  • It is widely accepted that the use of preoperative angiographic embolization reduces the occurrence of intraoperative bleeding and facilitates tumour removal.
  • We highlight the preoperative evaluation of tumour extent, using both computed tomography (CT) and magnetic resonance angiography, and the importance of temporary clamping of the external carotid artery intraoperatively.

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  • (PMID = 19010758.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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47. Tinoco RC, Tinoco AC, El-Kadre LJ, Rios RA, Sueth DM, Pena FM: [Laparoscopic transhiatal esophagectomy: outcomes]. Arq Gastroenterol; 2007 Apr-Jun;44(2):141-4
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  • BACKGROUND: The laparoscopic transhiatal esophagectomy for benign or malignant disease is a complex operation associated with a high rate of morbidity and mortality.
  • In the last decade this procedure gained popularity and acceptance for treatment of the esophagus cancer and other benign diseases.
  • Sixty-four with malignant neoplasm of esophagus.
  • The stomach was pulled up to the neck by the posterior mediastinum.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17962860.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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48. Satpathy A, Moss C, Raafat F, Slator R: Spontaneous regression of a rare tumour in a child: angiolymphoid hyperplasia with eosinophilia of the hand: case report and review of the literature. Br J Plast Surg; 2005 Sep;58(6):865-8
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  • [Title] Spontaneous regression of a rare tumour in a child: angiolymphoid hyperplasia with eosinophilia of the hand: case report and review of the literature.
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign, idiopathic vasculoproliferative condition manifested by multiple or solitary subcutaneous nodules, usually in the head and neck region of young adults.
  • Angiolymphoid hyperplasia is a benign disease and it is important to recognise this condition so that early superficial lesions can be observed for 3-6 months pending spontaneous regression.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Hand. Neoplasm Regression, Spontaneous

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  • (PMID = 16086996.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 30
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49. Aggarwal G, Satsangi B, Shukla S, Lahoti BK, Mathur RK, Maheshwari A: Rare asymptomatic presentations of schwannomas in early adolescence: three cases with review of literature. Int J Surg; 2010;8(3):203-6
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  • INTRODUCTION: Schwannoma also known as Neurilemoma is a benign neoplasm of the Schwann Cells of the neural sheath.
  • They are usually found to occur in the extremities, but can also be found in the trunk, head and neck, pelvis, and rectum.
  • [MeSH-minor] Adolescent. Back. Child. Head and Neck Neoplasms / diagnosis. Humans. Male. Pancreatic Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20167297.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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50. Shimada K, Sakamoto Y, Esaki M, Kosuge T, Hiraoka N: Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body. Dig Surg; 2008;25(1):46-51
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  • [Title] Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body.
  • BACKGROUND/AIM: Medial pancreatectomy has been applied as a safe and effective alternative in benign diseases located in the pancreatic neck or body.
  • Three patients with islet cell tumor and 1 patient with solid pseudopapillary tumor had no malignant disease.
  • CONCLUSIONS: A medial pancreatectomy is a safe and effective alternative for the treatment of intraductal papillary mucinous neoplasm, islet cell tumor, or solid pseudopapillary tumor located in the neck or body of the pancreas.

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  • (PMID = 18292661.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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51. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CONCLUSION: Rapid, accurate diagnosis of these tumors is important, particularly when they develop at sites where a metastatic process must be ruled out.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Anaplasia. Cell Differentiation. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Middle Aged. Necrosis. Neoplasm Invasiveness. Predictive Value of Tests

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Vandergriff TW, Reed JA, Orengo IF: An unusual presentation of atypical fibroxanthoma. Dermatol Online J; 2008;14(1):6
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  • Atypical fibroxanthoma (AFX) is a rare cutaneous spindle-cell neoplasm.
  • The tumor occurs most commonly in sun-damaged skin of the head and neck in elderly patients.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 18319023.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Chirletti P, Peparini N, Caronna R, Fanello G, Delogu G, Meniconi RL: Roux-en-Y end-to-end and end-to-side double pancreaticojejunostomy: application of the reconstructive method of the Beger procedure to central pancreatectomy. Langenbecks Arch Surg; 2010 Jan;395(1):89-93
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  • PURPOSES: Central pancreatectomy is indicated for treatment of traumatic lesions and benign or low-grade tumors of the pancreatic neck and proximal body.
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Length of Stay. Neoplasm Staging. Reconstructive Surgical Procedures / methods. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19707783.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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54. Souissi A, Fenniche S, Benmously R, Marrak H, Ben Jannet S, Mokhtar I: [Acanthosis nigricans: epidemiologic study of 69 cases]. Tunis Med; 2008 Jan;86(1):59-62
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  • BACKGROUND: Acanthosis nigricans is a well-defined skin disorder with a distinctive appearance and an elective topography to the flexural areas that facilitate its diagnosis.
  • The neck (98.6%) and the axillae (75.4%) represented the most common localizations.
  • All the patients presented a benign AN, comprising 51 cases of pseudo-AN, 11 cases of AN associated with endocrine diseases, 5 cases of familial AN and 2 cases of AN associated with an auto-immune disease.
  • AN constitutes a double cutaneous marker, being able to reveal either an hyperinsulinemia constituting a cardiovascular risk factor or an ignored subjacent neoplasm engaging the vital prognosis.

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  • (PMID = 19472702.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
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55. Naumann IC, Cordes SR: Giant basal cell carcinoma of the forehead with extensive intracranial involvement. Ann Otol Rhinol Laryngol; 2007 Sep;116(9):663-6
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  • Improper removal or neglect of BCC is a particular problem for head and neck surgeons.
  • Despite its fairly benign growth pattern, BCC should never be underestimated, and care should be taken not only in the complete primary excision but also in cancer surveillance.
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Forehead. Head and Neck Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnostic imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures / methods. Reconstructive Surgical Procedures / methods. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 17926588.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Ibekwe TS, Kokong DD, Ngwu BA, Akinyemi OA, Nwaorgu OG, Akang EE: Nasal septal teratoma in a child. World J Surg Oncol; 2007;5:58
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  • BACKGROUND: Teratoma is a rare developmental neoplasm that arises from totipotential tumor stem cells.
  • Head and neck teratomas constitute about 10% of all cases.
  • CONCLUSION: The prognosis for benign teratoma of the nasal septum is good following total surgical excision.

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  • (PMID = 17540035.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1891297
  • [General-notes] NLM/ Original DateCompleted: 20070730
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57. Carter JJ, Kaur MR, Hargitai B, Brown R, Slator R, Abdullah A: Congenital desmoplastic trichoepithelioma. Clin Exp Dermatol; 2007 Sep;32(5):522-4
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  • Desmoplastic trichoepithelioma (DT) is a rare benign adnexal neoplasm considered to have follicular differentiation.
  • A girl was born at term to a healthy mother after an uneventful pregnancy and was noted to have widespread erythematous plaques with milia-like lesions over the right scalp, face and neck, with some areas of atrophic scarring.

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  • (PMID = 17459070.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Coutinho-Camillo CM, Brentani MM, Nagai MA: Genetic alterations in juvenile nasopharyngeal angiofibromas. Head Neck; 2008 Mar;30(3):390-400
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors.
  • Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension.
  • Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial.
  • Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor.

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18228521.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / beta Catenin; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 103
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59. Rahbari R, Sansano IG, Elaraj DM, Duh QY, Clark OH, Kebebew E: Prior head and neck radiation exposure is not a contraindication to minimally invasive parathyroidectomy. J Am Coll Surg; 2010 Jun;210(6):942-8
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  • [Title] Prior head and neck radiation exposure is not a contraindication to minimally invasive parathyroidectomy.
  • In patients with a history of head and neck irradiation, due to the increased risk of multigland disease and risk of concurrent thyroid cancer, minimally invasive parathyroidectomy is considered by some to be a contraindication.
  • We postulated that previous history of head and neck irradiation should not be a contraindication for minimally invasive parathyroidectomy and tested this hypothesis in a prospective cohort of patients undergoing parathyroidectomy for primary hyperparathyroidism.
  • RESULTS: Fifty-two (12.6%) patients had a history of head and neck irradiation and 360 (87.4%) had no exposure to radiation.
  • There was no significant difference in concurrent benign thyroid neoplasm, thyroid cancer, and type of parathyroid disease (single vs multigland) in the 2 groups.
  • CONCLUSIONS: Head and neck irradiation should not be a contraindication for minimally invasive parathyroidectomy in patients with primary hyperparathyroidism in the setting of preoperative localization studies showing single-gland disease and no concurrent thyroid neoplasm.
  • Furthermore, history of head and neck irradiation is associated with a later age of presentation for parathyroidectomy.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Hyperparathyroidism, Primary / surgery. Parathyroidectomy. Radiotherapy. Thyroid Neoplasms / radiotherapy

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20510803.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Münz M, Zeidler R, Gires O: The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Cancer Lett; 2005 Jul 8;225(1):151-7
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  • [Title] The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP.
  • The epithelial cell adhesion molecule, EpCAM, is a transmembrane glycoprotein associated with both benign and malignant proliferation.
  • In cancer cells, expression levels of this tumour-associated antigen correlate positively with the grade of dysplasia and are also a negative prognostic factor for breast cancer patients.
  • Additionally, E-FABP levels correlated with the amount of EpCAM in permanent squamous cell carcinoma lines and in vivo in primary head and neck carcinomas.
  • Taken together, these results provide further evidence for the direct involvement of EpCAM in signalling processes, gene regulation, and cellular metabolism supporting its important role in tumour biology.
  • [MeSH-major] Antigens, Neoplasm / physiology. Carcinoma, Squamous Cell / genetics. Cell Adhesion Molecules / physiology. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Antigens, Differentiation. Carrier Proteins. Cell Proliferation. Epithelial Cells. Fatty Acid-Binding Proteins. Fatty Acids. Genes, myc. Humans. Proteome. Signal Transduction. Tumor Cells, Cultured. Up-Regulation

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  • (PMID = 15922867.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Antigens, Neoplasm; 0 / Carrier Proteins; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human; 0 / FABP5 protein, human; 0 / Fatty Acid-Binding Proteins; 0 / Fatty Acids; 0 / Proteome
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61. Haymart MR, Glinberg SL, Liu J, Sippel RS, Jaume JC, Chen H: Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf); 2009 Sep;71(3):434-9
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  • Despite the rise in the benign subgroups, mean TSH was consistently higher in those with cancer vs. those without.
  • On multivariate analysis of high-risk features associated with poor prognosis, there was a significant association between higher TSH and extrathyroidal extension (P = 0.002), whereas there was no clear relationship with age, tumour size > 4 cm, and distant metastases.
  • [MeSH-minor] Adult. Age Factors. Aged. Cohort Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Young Adult

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  • (PMID = 19067720.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T35 DK062709
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin
  • [Other-IDs] NLM/ NIHMS778777; NLM/ PMC4852738
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62. Ushio M, Takeuchi N, Kikuchi S, Kaga K: Inflammatory pseudotumour of the paranasal sinuses--a case report. Auris Nasus Larynx; 2007 Dec;34(4):533-6
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  • Inflammatory pseudotumour represents benign non-specific granulation, and is uncommon in the head-and-neck region, particularly in the paranasal sinuses.
  • [MeSH-major] Diplopia / etiology. Granuloma, Plasma Cell / diagnosis. Neoplasm Recurrence, Local / diagnosis. Orbital Neoplasms / diagnosis. Paranasal Sinus Diseases / diagnosis
  • [MeSH-minor] Anti-Inflammatory Agents / administration & dosage. Biopsy. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Paranasal Sinuses / pathology. Prednisolone / administration & dosage. Tomography, X-Ray Computed

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  • (PMID = 17331689.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 9PHQ9Y1OLM / Prednisolone
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63. Hussein MR, Elsers DA, Fadel SA, Omar AE: Clinicopathological features of melanocytic skin lesions in Egypt. Eur J Cancer Prev; 2006 Feb;15(1):64-8
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  • The lesions examined included 12 benign naevi (BN), 10 dysplastic naevi (DN), and 21 cutaneous malignant melanomas (CMMs).
  • The lower limb (13/21, 62%), head and neck (7/21, 33%) were the most common sites for CMMs.
  • The mean tumour thickness (Breslow) was 6+/-0.5 mm.
  • In Egypt, CMM is the third most common cutaneous neoplasm following squamous and basal cell carcinomas.

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  • (PMID = 16374232.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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64. Yao M, Funk GF, Goldstein DP, DeYoung BR, Graham MM: Benign lesions in cancer patients: Case 1. Sarcoidosis after chemoradiation for head and neck cancer. J Clin Oncol; 2005 Jan 20;23(3):640-1
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  • [Title] Benign lesions in cancer patients: Case 1. Sarcoidosis after chemoradiation for head and neck cancer.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / radiotherapy. Radiation Injuries / pathology. Sarcoidosis / etiology
  • [MeSH-minor] Cisplatin / administration & dosage. Combined Modality Therapy. Diagnosis, Differential. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm Metastasis. Positron-Emission Tomography. Radiopharmaceuticals


65. Schmidt M, Dietlein M, Schröder U, Schicha H: False-positive uptake of I-131 in a laryngocele mimicking thyroid remnant after thyroidectomy for papillary thyroid carcinoma. Clin Nucl Med; 2006 Nov;31(11):716-7
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  • Radioiodine therapy revealed intense radioiodine uptake of the neck, which was interpreted as thyroid remnant tissue.
  • Follow-up whole-body scans with iodine-131 in hypothyroidism 3 months and 1 year after radioiodine therapy revealed focal uptake in the neck.
  • Computed tomography and gadolinium-enhanced MRI of the neck demonstrated an ovoid lesion in the larynx without gadolinium enhancement.
  • Further examination of the patient in the ear, nose and throat department confirmed the finding of a laryngocele and biopsies demonstrated benign tissue.
  • Follow-up whole-body scans with iodine-131 in hypothyroidism 3 years and after injection of rhTSH 5 years after radioiodine therapy reproduced the focal uptake in the neck.
  • [MeSH-major] Carcinoma, Papillary / radionuclide imaging. Iodine Radioisotopes. Laryngeal Diseases / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging

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  • (PMID = 17053394.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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66. Hosseini SM, Borghei P, Borghei SH, Ashtiani MT, Shirkhoda A: Angiofibroma: an outcome review of conventional surgical approaches. Eur Arch Otorhinolaryngol; 2005 Oct;262(10):807-12
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor of the nasopharynx, and for its treatment, many surgical approaches have been recommended.
  • However, selecting the appropriate one for the tumor in an advanced stage is still controversial.
  • Involvement of the orbit, middle cranial fossa and base of the pterygoid by the primary JNA results in a higher incident of recurrent tumor.
  • Among different surgical techniques, the lowest recurrence rate is seen either in the transpalatal approach when the tumor is limited to the nasopharynx with extension to the nasal cavity or paranasal sinuses or with the Lefort I approach when skull base invasion is present.
  • [MeSH-major] Angiofibroma / surgery. Nasopharyngeal Neoplasms / surgery. Neoplasm Recurrence, Local / epidemiology. Otorhinolaryngologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Child. Disease-Free Survival. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15739087.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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67. Papaspyrou K, Rossmann H, Fottner C, Weber MM, Mann W, Lackner KJ, Helling K: Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report. Head Neck; 2008 Jul;30(7):964-9
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  • BACKGROUND: Paragangliomas of the head and neck are rare, mostly benign tumors.
  • The patient's father reportedly suffered from bilateral carotid body tumors.
  • There was no increased hormone production by the tumor.
  • [MeSH-minor] Adult. Biopsy, Needle. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Male. Neoplasm Staging. Pedigree. Positron-Emission Tomography. Risk Assessment. Treatment Refusal

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  • (PMID = 18213727.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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68. Kruse AL, Zwahlen RA, Grätz KW: New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol; 2009;1:31
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  • BACKGROUND: The ameloblastic carcinoma is a rare malignant odontogenic tumor which rather occurs in the mandible than in the maxilla.
  • Current classifications do not consider benign histopathological features at the primary and malignant features at the metastatic tumour site.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Evidence-Based Medicine. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19674470.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2733136
  • [General-notes] NLM/ Original DateCompleted: 20100629
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69. Eversole R, Su L, ElMofty S: Benign fibro-osseous lesions of the craniofacial complex. A review. Head Neck Pathol; 2008 Sep;2(3):177-202
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  • [Title] Benign fibro-osseous lesions of the craniofacial complex. A review.
  • Benign fibro-osseous lesions of the craniofacial complex are represented by a variety of disease processes that are characterized by pathologic ossifications and calcifications in association with a hypercellular fibroblastic marrow element.
  • [MeSH-minor] DNA, Neoplasm / analysis. Humans. Mutation

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  • (PMID = 20614314.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2807558
  • [Keywords] NOTNLM ; Benign fibroosseous lesions / Cementoma / Cementoosseous dysplasia / Fibrous dysplasia / Ossifying fibroma / Osteitis deformans
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70. Strobel K, Haerle SK, Stoeckli SJ, Schrank M, Soyka JD, Veit-Haibach P, Hany TF: Head and neck squamous cell carcinoma (HNSCC)--detection of synchronous primaries with (18)F-FDG-PET/CT. Eur J Nucl Med Mol Imaging; 2009 Jun;36(6):919-27
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  • [Title] Head and neck squamous cell carcinoma (HNSCC)--detection of synchronous primaries with (18)F-FDG-PET/CT.
  • PURPOSE: The aim of the study was to evaluate (18)F-FDG-PET/CT for the detection of synchronous primaries at initial staging of patients with head and neck squamous cell carcinoma (HNSCC).
  • Of the 56 second cancers, 46 (82%) were found in the aerodigestive tract in the following locations: lung (26, 46%), head and neck (15, 17%), oesophagus (5, 9%).
  • Nine synchronous cancers were not detected by PET/CT (four head and neck, two lung, two oesophageal, one gastric).
  • False-positive PET/CT findings were mainly related to benign FDG uptake in the intestine due to benign or precancerous polyps or physiological FDG uptake in other head and neck regions.
  • Synchronous cancers were predominantly located in the aerodigestive tract, primarily in the lung, head and neck and oesophagus.
  • [MeSH-major] Fluorodeoxyglucose F18. Head and Neck Neoplasms / diagnostic imaging. Neoplasms, Multiple Primary / diagnostic imaging. Neoplasms, Squamous Cell / diagnostic imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. False Positive Reactions. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / diagnostic imaging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19205699.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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71. Wu J, Rosenbaum E, Begum S, Westra WH: Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis. Am J Dermatopathol; 2007 Dec;29(6):534-7
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  • [Title] Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis.
  • The rate varied only slightly by anatomic site: BRAF mutations were detected in 21 of 21 (100%) nevi of the head and neck, 62 of 76 (82%) nevi of the trunk, 8 of 14 (62%) nevi of the extremities, and 18 of 24 (75%) anogenital nevi.
  • [MeSH-minor] Adolescent. Adult. Aged. Anus Neoplasms / genetics. Anus Neoplasms / pathology. Anus Neoplasms / surgery. Back / pathology. Child. DNA Mutational Analysis. DNA, Neoplasm / analysis. Extremities / pathology. Female. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Male. Microdissection. Middle Aged. Urogenital Neoplasms / genetics. Urogenital Neoplasms / pathology. Urogenital Neoplasms / surgery

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  • (PMID = 18032947.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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72. Gaut AW, Jay AP, Robinson RA, Goh JP, Graham SM: Invasive glomus tumor of the nasal cavity. Am J Otolaryngol; 2005 May-Jun;26(3):207-9
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  • [Title] Invasive glomus tumor of the nasal cavity.
  • Glomus tumors are neoplasms that occur only rarely in the head and neck.
  • These tumors are usually distinguished by benign growth characteristics.
  • We present a case of a large intranasal glomus tumor which, at presentation, had eroded through the ethmoid roof to involve the floor of the anterior cranial fossa.
  • To our knowledge, this is the first report of an invasive glomus tumor of the head and neck.
  • [MeSH-major] Glomus Tumor / pathology. Head and Neck Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Nasal Cavity. Neoplasm Invasiveness

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  • (PMID = 15858779.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Jonas NE, Page J, Mukonoweshuro W, Toynton S: Radiology quiz case 1. Benign osteoblastoma. Arch Otolaryngol Head Neck Surg; 2005 Dec;131(12):1116, 1118
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  • [Title] Radiology quiz case 1. Benign osteoblastoma.
  • [MeSH-minor] Adolescent. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Orbital Neoplasms / pathology. Orbital Neoplasms / radiography

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  • (PMID = 16365228.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Mendes RA, Carvalho JF, Waal Iv: An overview on the expression of cyclooxygenase-2 in tumors of the head and neck. Oral Oncol; 2009 Oct;45(10):e124-8
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  • [Title] An overview on the expression of cyclooxygenase-2 in tumors of the head and neck.
  • Cyclooxygenase-2 (COX-2) levels are increased in various tumors, particularly those involving the esophagus, stomach, breast, pancreas, lung, colon, skin, urinary bladder, prostate and head and neck.
  • Thus, the literature shows increasing evidence that overexpression of the COX-2 plays an important role in tumor growth and spread of tumors by interfering with different biological processes such as cell proliferation, cellular adhesion, immune surveillance, apoptosis, and angiogenesis.
  • Furthermore, the expression of COX-2 might shed some light over the physiopathology and clinical behavior of tumors of the head and neck, including benign odontogenic neoplasms of the jaws with an aggressive behavior, such as keratocystic odontogenic tumors (KCOT).
  • Ultimately, the research of molecular markers associated with the biological behavior of tumors will help to understand the underlying molecular mechanisms and to predict the clinical outcome, leading to the development of new therapeutic applications, such as molecular-targeted treatment and patient tailored therapy.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Head and Neck Neoplasms / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 19457709.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Prostaglandins; EC 1.14.99.1 / Cyclooxygenase 2
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75. Coffin CM, Lowichik A, Putnam A: Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol; 2009 Nov;33(11):1705-12
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  • Lipoblastoma (LPB) is a benign neoplasm that occurs predominantly in early childhood.
  • Sixty-four percent arose on the trunk, 27% on the extremities, and 8% in the head/neck.
  • Tumor diameter ranged from 1.2 to 15.5 cm.
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adolescent. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Child. Child, Preschool. Chromosome Aberrations. Chromosomes, Human, Pair 8. Female. Humans. Immunohistochemistry. Infant. Male. Neoplasm Recurrence, Local. S100 Proteins / analysis


76. Chung SW, Kwon SY, Jung KY, Woo JS: Synchronous double primary cancers of the unilateral parotid gland. Acta Otolaryngol; 2007 Feb;127(2):209-12
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  • A review of the literature revealed that most reported cases were either a combination of two distinct benign neoplasms or a benign neoplasm and another malignant tumor.

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  • (PMID = 17364354.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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77. Agaimy A, Wünsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T: Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. J Clin Pathol; 2008 Mar;61(3):301-6
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  • AIMS: Low-grade myofibroblastic sarcoma (LGMS) represents a rare soft tissue neoplasm with a predilection for the head and neck.
  • Genomic DNA was isolated from microdissected formalin-fixed paraffin-embedded tumour tissue and examined for KIT and PDGFRA mutations by PCR and direct sequencing of KIT and PDGFRA.
  • The tumour cells strongly expressed vimentin, variably alpha-smooth muscle actin and fibronectin, but were negative for CD117, S-100, desmin, h-caldesmon, beta-catenin, ALK-1, MDM2, PDGFRalpha and PDGFRbeta.
  • One tumour showed a weak expression of CD34.
  • LGMS may mimic a variety of benign and low-grade malignant neoplasms and might be under-recognised.
  • [MeSH-major] Neoplasm Recurrence, Local / ultrastructure. Peritoneal Neoplasms / ultrastructure. Sarcoma / ultrastructure. Soft Tissue Neoplasms / ultrastructure
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. DNA Mutational Analysis. Female. Fibronectins / analysis. Humans. Immunohistochemistry. Mesentery. Middle Aged. Mitotic Index. Pelvis. Proto-Oncogene Proteins c-kit / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Vimentin / analysis

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  • (PMID = 17513510.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 38
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78. Nonose R, Priolli DG, Cardinalli IA, Máximo FR, Galvão PS, Martinez CA: Epithelioid hemangioma of the colon: a case report. Sao Paulo Med J; 2008 Sep;126(5):294-6
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  • CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon benign vascular neoplasm that is usually located on the face or neck.
  • Neoplasia of the colon was clinically suspected and she underwent colonoscopy.
  • A biopsy collected during the examination suggested a diagnosis of neoplasia of vascular origin.
  • Despite the rarity of neoplasia of vascular origin, this possibility should be considered in the differential diagnosis for colorectal tumors.

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  • (PMID = 19099166.001).
  • [ISSN] 1806-9460
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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79. Orita Y, Hamaya K, Miki K, Sugaya A, Hirai M, Nakai K, Nose S, Yoshino T: Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland. Eur Arch Otorhinolaryngol; 2010 May;267(5):801-6
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  • [Title] Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland.
  • The occasional local recurrence of benign pleomorphic adenoma (PA) has generally been attributed to the vulnerability of the tumor capsule.
  • Although some reports have also noted the presence of satellite tumors associated with PA recurrence, only few reports have focused on this issue.
  • We paid special attention to the satellite lesions apart from the main tumors and discussed their frequency, origin, nature and the ways of treating them.
  • Four (3.7%) patients displayed a main mass with satellite tumors in a single parotid gland.
  • The immunohistochemical analysis of p53 and Ki-67 index showed no distinct difference between PAs with satellite tumors and those without.
  • Satellite tumors surrounding the main mass of parotid PA is relatively rare.
  • In most cases, such satellite tumors will arise from capsular perforation of the primary tumor cells.
  • Preoperative evaluation to recognize the existence of satellite tumors would be important and capsular dissection should be discouraged.
  • We could not find any evidence suggesting that primary PA with satellite tumors could be more biologically aggressive than those without.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Genes, p53 / genetics. Humans. Immunohistochemistry. Infant. Infant, Newborn. Ki-67 Antigen / genetics. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Point Mutation / genetics. Preoperative Care

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  • (PMID = 19898859.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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80. Troncone G, Iaccarino A, Russo M, Palmieri EA, Volante M, Papotti M, Viglietto G, Palombini L: Accumulation of p27(kip1) is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma. J Clin Pathol; 2007 Apr;60(4):377-81
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  • However, the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma expresses more p27 than benign oxyphilic lesions do.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Cyclins / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adenoma / metabolism. Adenoma / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Cyclin D3. Humans. Immunoprecipitation. Neoplasm Proteins / metabolism

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  • [Cites] Arch Otolaryngol Head Neck Surg. 2002 Mar;128(3):253-7 [11886339.001]
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  • (PMID = 16798934.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CCND3 protein, human; 0 / Cyclin D3; 0 / Cyclins; 0 / Neoplasm Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ PMC2001124
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81. Subhashraj K, Balanand S, Pajaniammalle S: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal; 2009 Jan;14(1):E12-4
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  • Schwannoma is an intraoral rare, benign neoplasm derived from the nerve sheath of peripheral nerves.
  • Ancient schwannoma of the head and neck region is relatively uncommon and very few cases had been reported in the oral cavity.
  • Ultrasonography showed that the tumor was closely associated with the mental nerve on the left side, suggestive of a peripheral neural sheath tumor.

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  • (PMID = 19114949.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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82. Power C, Kavanagh D, Hill AD, O'Higgins N, McDermott E: Unusual presentation of a giant parathyroid adenoma: report of a case. Surg Today; 2005;35(3):235-7
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  • Certain symptoms and biochemical abnormalities alert the surgeon to their presence, since these benign tumors are rarely evident on physical examination.
  • Moreover, because they are usually very small, preoperative localization using sestamibi scanning or ultrasonography is required to avoid bilateral neck exploration.
  • Interestingly, despite its huge size it did not cause many of the hypercalcemic symptoms usually associated with larger adenomas, but rather it manifested with symptoms of local pressure, another unusual property of this atypical tumor.
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Hyperparathyroidism / diagnosis. Hyperparathyroidism / etiology. Immunohistochemistry. Ireland. Neoplasm Staging. Parathyroidectomy / methods. Risk Assessment. Severity of Illness Index. Treatment Outcome

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  • (PMID = 15772795.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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83. Brochard C, Michalak S, Aubé C, Singeorzan C, Fournier HD, Laccourreye L, Calès P, Boursier J: A not so solitary fibrous tumor of the liver. Gastroenterol Clin Biol; 2010 Dec;34(12):716-20
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  • [Title] A not so solitary fibrous tumor of the liver.
  • Solitary fibrous tumor (SFT) is a rare neoplasm.
  • Liver parenchyma is a rare location of SFT and, in this case, it usually follows a benign course.
  • We report here the case of a 54-year-old man who presented a large SFT tumor of the right hepatic lobe.
  • The tumor was surgically resected.
  • Local recurrence occurred 6 years later as a 15 cm diameter liver tumor.
  • Two years later, the patient presented with complaints of neck pain and ensuing examinations revealed a tumor of the cranial base.
  • [MeSH-major] Liver Neoplasms / pathology. Skull Base Neoplasms / secondary. Solitary Fibrous Tumors / secondary

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20864281.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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84. Koch M, Dimmler A, Alexiou C: [Recurrent and metastasizing atypical fibroxanthoma]. HNO; 2008 Oct;56(10):1046-51
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  • Atypical fibroxanthoma is a rare skin tumor that arises particularly on sun-exposed skin.
  • Although it is considered to be a benign tumor, rarely, metastases arise.
  • A complete tumor excision was performed, and the patient declined the recommended postoperative radiotherapy.
  • [MeSH-major] Ear Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Neoplasm Recurrence, Local / surgery. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery

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  • (PMID = 18210006.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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85. Saini R, Abd Razak NH, Ab Rahman S, Samsudin AR: Chondrosarcoma of the mandible: a case report. J Can Dent Assoc; 2007 Mar;73(2):175-8
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  • They range from a well-differentiated growth resembling a benign cartilage tumour to a high-grade malignancy with aggressive local behaviour and the potential to metastasize.
  • Only 5% to 10% of chondrosarcomas are known to occur in the head and neck region.
  • [MeSH-minor] Adult. Female. Humans. Neoplasm, Residual / radiotherapy

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  • (PMID = 17355810.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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86. Nazarian Y, Talmi YP, Wolf M, Horowitz Z, Bedrin L, Pfeffer R, Kronenberg J: [Recurrent pleomorphic adenomas of the parotid gland--treatment and outcome]. Harefuah; 2007 Feb;146(2):82-4, 168
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  • Epithelial tumors of the parotid gland comprise 3% of head and neck tumors, and 70%-80% of those are benign.
  • Pleomorphic adenoma is the most common tumor of the parotid gland.
  • Recurrence rate of pleomorphic adenomas (RPAs) following superficial parotidectomy was reported to be as high as 4%, sometimes associated with inadequate surgical treatment of the primary tumor.
  • These tumors have a very slow growth rate, and a ten-year follow-up period is mandatory.
  • [MeSH-major] Adenoma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17352271.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
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87. Harikumar R, Simikumar, Aravindan SK, Thomas V: Abrikosoff's tumor of the esophagus: case report and review of literature. Trop Gastroenterol; 2006 Jan-Mar;27(1):52-3
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  • [Title] Abrikosoff's tumor of the esophagus: case report and review of literature.
  • Abrikosoff's tumor or granular cell tumor is a neoplasm of neural origin, usually located in the head and neck region.
  • A majority of these neoplasms are benign.
  • Only 4-6% of granular cell tumors are located in the gastrointestinal tract.
  • It is extremely unusual for these tumors to be located in the esophagus.
  • [MeSH-major] Esophageal Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 16910065.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 13
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88. Wygledowska-Kania M, Kamińska-Winciorek G, Krauze E, Brzezińska-Wcisło L, Kajor M: Multifocal type of pilomatrixoma. Adv Med Sci; 2007;52:251-3
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  • Pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • The skin lesion occurs usually as a solitary tumor and the multifocal types are very rare.
  • Skin changes can be described as a firm to hard, non-painful, oval-shaped tumor that is covered by normal skin.
  • It commonly occurs on a scalp, face, neck and rarely back and extremities.
  • In this paper case of 16-years-old male patient with many solid tumors in subcutaneous tissue on both arms will be reported.

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  • (PMID = 18217427.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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89. Thompson LD, Karamurzin Y, Wu ML, Kim JH: Solitary fibrous tumor of the larynx. Head Neck Pathol; 2008 Jun;2(2):67-74
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  • [Title] Solitary fibrous tumor of the larynx.
  • Extrapleural solitary fibrous tumor (SFT) is a localized neoplasm characterized by proliferation of thin-walled vessels and collagen-producing cells and is considered within the "hemangiopericytoma-solitary fibrous tumor" spectrum.
  • A cellular, spindle cell neoplasm was arranged in loose fascicles, associated with heavy collagen fiber deposition.
  • These findings confirmed a diagnosis of extraplural solitary fibrous tumor.
  • CONCLUSIONS: The characteristic histologic pattern of solitary fibrous tumor can be noted in extrapulmonary locations.
  • Development in the larynx is uncommon, but the tumor presents as a polypoid mass with characteristic histologic and immunophenotypic features.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Disease-Free Survival. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 20614325.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807554
  • [Keywords] NOTNLM ; Benign neoplasm / CD34 / Fibroma / Hemangiopericytoma / Immunohistochemistry / Larynx / Mesenchymal tumor / Prognosis / Solitary fibrous tumor / Spindle cell squamous cell carcinoma / Surgery / True vocal cord / bcl-2
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90. Bakoyiannis KC, Georgopoulos SE, Klonaris CN, Tsekouras NS, Felekouras ES, Pikoulis EA, Griniatsos JE, Papalambros EL, Bastounis EA: Surgical treatment of carotid body tumors without embolization. Int Angiol; 2006 Mar;25(1):40-5
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  • [Title] Surgical treatment of carotid body tumors without embolization.
  • AIM: Carotid body (CB) paragangliomas are rare neoplasms, usually benign.
  • METHODS: During a 10-year period, from 1995 to 2004, we studied the medical records of 11 patients with CB tumors, 8 males and 3 females, whom only one had bilateral tumors.
  • Their age ranged from 23 to 65 years (mean 35 years) and all had a palpable neck mass.
  • Twelve tumors were surgically resected and no patient underwent preoperative selective embolism of his tumor.
  • One patient, with a grade III tumor, had an injury of the internal carotid artery that was repaired with a vein patch.
  • Preoperative embolism of the tumor does not need to be a routine procedure.
  • [MeSH-major] Carotid Body Tumor / surgery. Endarterectomy, Carotid
  • [MeSH-minor] Adult. Aged. Angioplasty. Female. Humans. Male. Medical Records. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16520723.001).
  • [ISSN] 0392-9590
  • [Journal-full-title] International angiology : a journal of the International Union of Angiology
  • [ISO-abbreviation] Int Angiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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91. Kim E, Bae TS, Kwon Y, Kim TH, Chung KW, Kim SW, Ro J, Lee ES: Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. J Korean Med Sci; 2007 Jun;22(3):568-71
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  • [Title] Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report.
  • Teratomas comprise the most common extragonadal germ cell tumors in childhood.
  • Most teratomas involving the thyroid are benign and occur in children.
  • We report a case of a 31-yr-old female with a huge neck mass.
  • She underwent total thyroidectomy with bilateral modified radical neck dissection, intensive chemotherapy and radiotherapy.
  • This is the first case, to our knowledge, of malignant thyroid teratoma with a exuberant primitive neuroectodermal tumor component in Korea.
  • [MeSH-major] Neuroectodermal Tumors, Primitive / complications. Neuroectodermal Tumors, Primitive / pathology. Teratoma / complications. Teratoma / pathology. Thyroid Gland / pathology
  • [MeSH-minor] Adult. Female. Head and Neck Neoplasms / pathology. Humans. Neoplasm Metastasis. Positron-Emission Tomography / methods. Thyroid Diseases / diagnosis. Thyroidectomy. Tomography, X-Ray Computed

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  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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92. Pudszuhn A, Welzel C, Bloching M, Neumann K: Intralesional Cidofovir application in recurrent laryngeal papillomatosis. Eur Arch Otorhinolaryngol; 2007 Jan;264(1):63-70
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  • Recurrent laryngeal papillomatosis is a benign disease of the larynx often leading to organic and functional restrictions.
  • [MeSH-minor] Adult. Aged. Child, Preschool. Combined Modality Therapy. Female. Human papillomavirus 11 / isolation & purification. Human papillomavirus 6 / isolation & purification. Humans. Laryngeal Mucosa / pathology. Laryngeal Mucosa / virology. Laser Therapy. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Remission Induction

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  • (PMID = 17058091.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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93. Kabukcuoglu F, Kabukcuoglu Y, Tanik C, Sakiz D, Karsidag S: Breast carcinoma metastasis in recurrent myxoid liposarcoma. Pathol Oncol Res; 2009 Sep;15(3):467-71
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  • Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor.
  • The tumor recurred twice and was reexcised.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Radiotherapy


94. do Nascimento KC, de Faria PR, Dib LL, Ferreira de Aguiar MC, Cardoso SV, Chen J, Loyola AM: Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior. Virchows Arch; 2006 Dec;449(6):660-6
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  • To evaluate the role of NM23 in SGN, the expression patterns of NM23 in the following were compared: benign (pleomorphic adenoma) vs malignant (adenoid cystic carcinoma and mucoepidermoid carcinoma) SGN, and primary malignancies with/without evidence of metastasis vs their metastatic implants (MI).
  • NM23 protein was found in the cytoplasm of 75% of benign SGN, 73.3% of primary SGN malignancies with no evidence of metastasis, 86.6% of primary SGN malignancies with evidence of metastasis, and 60% of MI.
  • There was no statistically significant difference in the frequency of NM23-positive cells between benign and primary malignant tumors (p = 0.79), nor between primary malignancies with/without evidence of metastasis and MI (p = 0.51).
  • [MeSH-minor] Humans. Immunohistochemistry. NM23 Nucleoside Diphosphate Kinases. Neoplasm Metastasis

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  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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95. Woźniak AW, Nowaczyk MT, Osmola K, Golusinski W: Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):845-9
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  • Benign osteoblastoma is a rarely seen tumor of the facial bones.
  • The authors present a case of a 30-year-old man with a tumor of the mandibular body and ramus.
  • A second recurrence occured in the pharyngo-glossal region and this time the tumor was histologically diagnosed as an osteoblastoma, but with foci of well-differentiated osteosarcoma.
  • While osteoblastomas are rare, and their sarcomatous change even rarer, our experience with this case lead us to suggest that a therapeutic preventative approach, involving both chemotherapy and total excision of the tumor, is the regime to adopt with osteoblastomas which involve soft tissues and have radiological features suggesting malignancy.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Osteoblastoma / pathology. Osteosarcoma / pathology

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96. Sugitani I, Toda K, Yamada K, Yamamoto N, Ikenaga M, Fujimoto Y: Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes. World J Surg; 2010 Jun;34(6):1222-31
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  • BACKGROUND: Papillary microcarcinoma (PMC) of the thyroid generally follows a benign clinical course.
  • Three patients (1%) who developed apparent lymph node metastasis and nine patients (4%) in whom tumor increased in size eventually received surgery after 1-12 years of follow-up.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Iodine Radioisotopes / therapeutic use. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Staging. Observation. Prognosis. Proportional Hazards Models. Prospective Studies. Risk Factors. Statistics, Nonparametric. Survival Rate. Thyroidectomy / methods. Ultrasonography

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  • (PMID = 20066418.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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97. Sheth S, Hamper UM: Role of sonography after total thyroidectomy for thyroid cancer. Ultrasound Q; 2008 Sep;24(3):147-54
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  • High-resolution neck ultrasound plays a vital role in the evaluation and management of patients after total thyroidectomy for thyroid cancer.
  • This technique is increasingly used by endocrinologists and head and neck surgeons to detect potential locoregional recurrences or metastases and map malignant lymph nodes before reoperation.
  • It is also invaluable as guidance for fine-needle aspiration of suspicious lesions.Thorough knowledge of the compartments of the neck and meticulous scanning technique are essential for success.The purpose of this article is to review the common pattern of recurrences of differentiated thyroid cancer, describe our scanning protocol, and depict the characteristics of benign, indeterminate, and suspicious lesions in the postthyroidectomy neck.
  • [MeSH-major] Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / ultrasonography. Thyroid Neoplasms / radiography. Thyroid Neoplasms / surgery. Thyroidectomy. Ultrasonography / methods

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  • (PMID = 18776787.001).
  • [ISSN] 1536-0253
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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98. Smith SL, Komisar A: Limited parotidectomy: the role of extracapsular dissection in parotid gland neoplasms. Laryngoscope; 2007 Jul;117(7):1163-7
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  • OBJECTIVE: Surgical techniques for parotid gland neoplasm removal have been shaped over the years by the importance of the gland's relationship with the facial nerve, histologic behavior of parotid tumors, and recurrence rates from specific techniques.
  • RESULTS: All tumors were located in the superficial lobe of the parotid gland and size of the masses ranged from 4.0 to 1.0 cm (mean 2.4 cm) in diameter.
  • Pathology of the parotid tumors consisted of 11 pleomorphic adenomas, six Warthin's tumors, six benign epithelial cysts, one sarcoid lesion, two lymphoid hyperplasia, and one Kaposi's sarcoma.
  • CONCLUSION: We advocate extracapsular dissection for benign parotid neoplasms because of the acceptable recurrence rates with limited complications as compared to superficial parotidectomy.

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  • [CommentIn] Laryngoscope. 2008 Feb;118(2):379; author reply 379-80 [18303396.001]
  • (PMID = 17632913.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Mack MG, Rieger J, Baghi M, Bisdas S, Vogl TJ: Cervical lymph nodes. Eur J Radiol; 2008 Jun;66(3):493-500
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  • The lymph node staging is a very important prognostic parameter for patients with presenting with head neck cancer and is influencing the selection of the different therapeutic strategies including surgery, chemotherapy, radiotherapy or a combination of them.
  • A spherical lymph node larger than 10mm is an indicator for a malignant node, whereas an oval shape and/or a fatty hilus are more benign signs.
  • But there are many limitations and different cut offs published in the literature, indicating that the size of a lymph node is not a reliable criteria for the assessment of lymph nodes in the head and neck region.
  • Today new high-resolution MRI sequences and the development of specific contrast agents are offering new possibilities in the diagnostic work-up of head and neck lymph nodes.
  • This is causing a signal decrease on T2-weighted MR images in benign lymph nodes after administration of USPIO's, whereas malignant lymph nodes do not show a significant signal decrease.
  • Based on the fact, that the size evaluation of lymph nodes in the head and neck has not changed during the last decade, this paper will mainly focus on MRI with new contrast agents and new techniques as diffusion weighted imaging (DWI).
  • [MeSH-major] Diagnostic Imaging. Head and Neck Neoplasms / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Contrast Media. Dextrans. Ferrosoferric Oxide. Humans. Iron. Lymph Nodes / pathology. Magnetite Nanoparticles. Neoplasm Invasiveness / diagnosis. Neoplasm Staging. Oxides. Prognosis

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  • (PMID = 18337039.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
  • [Number-of-references] 45
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100. Schiro AJ, Pinchot SN, Chen H, Sippel RS: Clinical efficacy of fine-needle aspiration biopsy of thyroid nodules in males. J Surg Res; 2010 Apr;159(2):645-50
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  • FNA biopsy results were reported as benign, malignant, inconclusive (i.e., follicular neoplasm), or nondiagnostic; final surgical pathology was reported as benign or malignant.
  • Preoperative FNA biopsy results were obtained in 60% of these male patients and were read as benign in 45/165 (27%) patients, malignant in 47/165 (28%) patients, inconclusive in 66/165 (40%) patients, and nondiagnostic in 7/165 (4%) patients.
  • In male patients with cytology reported as benign, 3/45 (6.7%) FNAs were determined to be malignant on final pathology.

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  • (PMID = 19932905.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA090217-01; United States / NCI NIH HHS / CA / T32 CA090217-04; United States / NCI NIH HHS / CA / CA090217-04; United States / NCI NIH HHS / CA / CA090217-02; United States / NCI NIH HHS / CA / CA090217-01; United States / NCI NIH HHS / CA / T32 CA090217-02; United States / NCI NIH HHS / CA / CA090217-03; United States / NCI NIH HHS / CA / T32 CA090217-03
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS213770; NLM/ PMC3087882
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