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1. North DW, Abdo KM, Benson JM, Dahl AR, Morris JB, Renne R, Witschi H: A review of whole animal bioassays of the carcinogenic potential of naphthalene. Regul Toxicol Pharmacol; 2008 Jul;51(2 Suppl):S6-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A statistically significant increased incidence of pulmonary alveolar/bronchiolar adenoma (a benign lesion), was observed among female mice; an observed increase among the males did not reach statistical significance.
  • No nasal tumors were observed in either sex.
  • A tumorigenic response was observed in both sexes of rats, in males an increased incidence of nasal respiratory epithelium adenoma (a benign rather than malignant lesion) and in females, olfactory epithelial neuroblastoma.
  • On the one hand, evidence of extensive non-neoplastic response in both sexes of both species indicates cytotoxicity occurred at all doses, and strongly suggests that cytotoxicity played a significant role in the tumor responses observed in the target tissues.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Administration, Inhalation. Animals. Bronchi / drug effects. Bronchi / pathology. Esthesioneuroblastoma, Olfactory / chemically induced. Esthesioneuroblastoma, Olfactory / pathology. Female. Inhalation Exposure. Lung Neoplasms / chemically induced. Lung Neoplasms / pathology. Male. Mice. Nasal Cavity / drug effects. Nasal Cavity / pathology. Nose Neoplasms / chemically induced. Nose Neoplasms / pathology. Olfactory Mucosa / drug effects. Olfactory Mucosa / pathology. Pulmonary Alveoli / drug effects. Pulmonary Alveoli / pathology. Rats

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  • (PMID = 18364246.001).
  • [ISSN] 1096-0295
  • [Journal-full-title] Regulatory toxicology and pharmacology : RTP
  • [ISO-abbreviation] Regul. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens, Environmental; 0 / Naphthalenes
  • [Number-of-references] 33
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2. Mullin LS, Kennedy GL Jr, Wood CK: Nasal tumors in rats following long-term inhalation exposure to 1,4-dichlorobutene-2 (DCB). Drug Chem Toxicol; 2000 Aug;23(3):403-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal tumors in rats following long-term inhalation exposure to 1,4-dichlorobutene-2 (DCB).
  • This study was conducted to elucidate the time- and dose-response relationships of long-term, low-level 1,4-dichlorobutene-2 (DCB) inhalation exposure to nasal tumor induction in rats.
  • Compound-related non-neoplastic lesions were observed in the nasal cavities of rats in the 1.0 ppm group after three months of exposure and in the other two groups after twelve months of exposure.
  • A statistically significant increase in benign nasal tumors (adenomas) occurred in rats from all three DCB-exposed groups.
  • The adenomas occurred in the respiratory region of the nasal cavity and were first observed in the 1.0 ppm group at study month 10.
  • Malignant nasal tumors occurred in the olfactory region of the nasal cavity and were statistically increased at 1.0 ppm.
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / complications. Adenocarcinoma / pathology. Administration, Inhalation. Animals. Body Weight / drug effects. Carcinogenicity Tests. Carcinosarcoma / chemically induced. Carcinosarcoma / pathology. Corynebacterium Infections / pathology. Dose-Response Relationship, Drug. Inhalation Exposure. Lung Diseases / complications. Lung Diseases / microbiology. Lung Diseases / pathology. Male. Nasal Cavity / drug effects. Nasal Cavity / pathology. Organ Size / drug effects. Precancerous Conditions / chemically induced. Precancerous Conditions / complications. Precancerous Conditions / pathology. Rats. Rhabdomyosarcoma / chemically induced. Rhabdomyosarcoma / pathology. Time Factors

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  • Hazardous Substances Data Bank. 1,4-DICHLORO-TRANS-2-BUTENE .
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  • (PMID = 10959544.001).
  • [ISSN] 0148-0545
  • [Journal-full-title] Drug and chemical toxicology
  • [ISO-abbreviation] Drug Chem Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Hydrocarbons, Chlorinated; 764-41-0 / 1,4-dichloro-2-butene
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