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1. Sayed SI, Kazi RA, Jagade MV, Palav RS, Shinde VV, Pawar PV: A rare myoepithelioma of the sinonasal cavity: case report. Cases J; 2008;1(1):29

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare myoepithelioma of the sinonasal cavity: case report.
  • Myoepithelioma is a rare benign neoplasm.
  • Pure accounting for less than 1% of all salivary gland tumors.
  • Only three cases of sinonasal myoepithelioma have been reported in the literature.
  • Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis.
  • We report to you a rare case of sinonasal myoepithelioma in a 57 year old Asian female.Myoepitheliomas are rare tumours that account for only about 1% of all salivary gland tumors.
  • Most are benign, but some can be malignant.
  • Only three cases of sinonasal myoepithelioma have been reported in the literature so far.

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  • (PMID = 18620583.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2483262
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2. Acikalin MF, Pasaoglu O, Cakli H, Gürbüz K, Canaz F: Malignant myoepithelioma of the palate: a case report with review of the clinicopathological characteristics. Yonsei Med J; 2009 Dec 31;50(6):848-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant myoepithelioma of the palate: a case report with review of the clinicopathological characteristics.
  • A malignant myoepithelioma is one of the rarest salivary gland neoplasms which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma.
  • The parotid gland is the most common primary site and the palate the most common intra-oral site of occurrence.
  • Herein is present a case of a malignant myoepithelioma arising in the hard palate of a 79-year-old woman.
  • Examination of the resection specimen showed the characteristic histopathological and immunohistochemical features of a malignant myoepithelioma.
  • [MeSH-major] Myoepithelioma / diagnosis. Myoepithelioma / pathology. Palatal Neoplasms / diagnosis. Palatal Neoplasms / pathology. Palate / pathology. Palate / surgery

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  • (PMID = 20046429.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2796415
  • [Keywords] NOTNLM ; Malignant myoepithelioma / palate
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3. Pons Vicente O, Almendros Marqués N, Berini Aytés L, Gay Escoda C: Minor salivary gland tumors: A clinicopathological study of 18 cases. Med Oral Patol Oral Cir Bucal; 2008 Sep;13(9):E582-8
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  • [Title] Minor salivary gland tumors: A clinicopathological study of 18 cases.
  • INTRODUCTION: Minor salivary gland tumors (MSGTs) are infrequent, representing 10-15% of all salivary neoplasms.
  • The great majority (94.4%) were benign tumors.
  • The histopathological diagnoses of our MSGTs comprised 10 pleomorphic adenomas (55.3%), 2 cystadenomas (11.1%), 1 myoepithelioma (5.6%), 1 sialadenoma papilliferum (5.6%), 1 basal cell adenoma (5.6%), 1 Warthin's tumor (5.6%), 1 canalicular adenoma (5.6%), and 1 low-grade polymorphic adenocarcinoma (5.6%).
  • Six percent of all benign minor salivary gland tumors are considered to relapse, versus 65% of all malignant lesions.
  • [MeSH-major] Salivary Gland Neoplasms / pathology. Salivary Glands, Minor

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  • (PMID = 18758404.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 30
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4. Testa D, Galera F, Insabato L, Vassallo A, Mesolella M, Galli V: Submandibular gland myoepithelioma. Acta Otolaryngol; 2005 Jun;125(6):664-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Submandibular gland myoepithelioma.
  • Benign myoepithelioma is a very rare form of salivary gland tumor, composed entirely of myoepithelial cells.
  • It accounts for approximately 1% of all salivary gland tumors and is most frequently located in the parotid gland and in the minor salivary glands of the hard palate.
  • We describe herein the ninth reported case of myoepithelioma of the submandibular gland.
  • Benign myoepithelioma must be differentiated from several benign and malignant epithelial and mesenchymal tumors.
  • [MeSH-major] Myoepithelioma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16076718.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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5. Habermann CR, Arndt C, Graessner J, Diestel L, Petersen KU, Reitmeier F, Ussmueller JO, Adam G, Jaehne M: Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible? AJNR Am J Neuroradiol; 2009 Mar;30(3):591-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible?
  • BACKGROUND AND PURPOSE: Our aim was to determine the value of echo-planar diffusion-weighted MR imaging (epiDWI) in differentiating various types of primary parotid gland tumors.
  • MATERIALS AND METHODS: One hundred forty-nine consecutive patients with suspected tumors of the parotid gland were examined with an epiDWI sequence by using a 1.5T unit.
  • Histologic diagnosis was obtained in every patient.
  • RESULTS: In 136 patients, a primary parotid gland tumor was confirmed by histology.
  • ADC values of Warthin tumors were different from those of myoepithelial adenomas, lipomas, and salivary duct carcinomas (P < .001, 0.013, and .037, respectively).
  • Due to an overlap not only within the group of benign and malignant lesions but also between groups, diagnoses should not be addressed on the basis of ADC values solely.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Echo-Planar Imaging. Myoepithelioma / pathology. Parotid Gland / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Female. Humans. Lipoma / pathology. Male. Middle Aged. Prospective Studies. Salivary Gland Neoplasms / pathology. Young Adult

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  • (PMID = 19131405.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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6. Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD: EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer; 2010 Dec;49(12):1114-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The diagnosis of myoepithelial (ME) tumors outside salivary glands remains challenging, especially in unusual clinical presentations, such as bone or visceral locations.
  • In conclusion, EWSR1 gene rearrangement is a common event in ME tumors arising outside salivary glands, irrespective of anatomical location.
  • EWSR1-negative tumors were more often benign, superficially located, and showed ductal differentiation, suggesting the possibility of genetically distinct groups.
  • These findings do not support a pathogenetic relationship between soft tissue ME tumors and their salivary gland counterparts.

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  • [Copyright] © 2010 Wiley-Liss, Inc.
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  • (PMID = 20815032.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calmodulin-Binding Proteins; 0 / DNA-Binding Proteins; 0 / EWSR1 protein, human; 0 / Octamer Transcription Factor-3; 0 / Oncogene Proteins, Fusion; 0 / POU5F1 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins; 0 / pbx1 protein, human
  • [Other-IDs] NLM/ NIHMS377724; NLM/ PMC3540416
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7. Angiero F, Sozzi D, Seramondi R, Valente MG: Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. Anticancer Res; 2009 Nov;29(11):4703-9
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  • [Title] Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features.
  • AIMS: Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland neoplasm that most commonly occurs in the parotid gland, but can also arise in the minor salivary glands.
  • Three cases are reported of epithelial-myoepithelial carcinoma of the minor salivary glands, with the goal of better defining this entity.
  • CONCLUSION: Three cases of minor salivary gland tumors are described and the differential diagnosis underlined in relation to benign myoepithelioma.
  • The characteristic morphological and immunohistochemical features aided diagnosis of these biphasic tumors.
  • [MeSH-major] Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology


8. Woo VL, Angiero F, Fantasia JE: Myoepithelioma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 May;99(5):581-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myoepithelioma of the tongue.
  • Soft tissue myoepitheliomas, in contrast to salivary gland myoepitheliomas, are benign neoplasms that typically occur in the soft tissues of the extremities.
  • We present a case of myoepithelioma of the tongue and review the literature, with emphasis on the differential diagnosis and histogenesis of this lesion and pertinent nosologic considerations.
  • [MeSH-major] Myoepithelioma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Membrane Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 15829881.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 30
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9. Shiomori T, Udaka T, Tokui N, Morio T, Ohbuchi T, Suzuki H: Giant myoepithelioma of the upper lip. Acta Otolaryngol; 2005 Aug;125(8):894-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant myoepithelioma of the upper lip.
  • Myoepithelioma is a relatively rare form of salivary gland tumor composed entirely of myoepithelial cells.
  • We report herein an extremely rare case of myoepithelioma of the upper lip.
  • A benign minor salivary gland tumor was clinically suspected, and the patient underwent complete resection of the tumor under general anesthesia.
  • The tumor was histopathologically diagnosed as a benign myoepithelioma of the minor salivary gland.
  • Immunohistochemically, the tumor cells were positive for vimentin, cytokeratins, alpha-smooth muscle actin and S-100 protein, confirming the morphological diagnosis of myoepithelioma.
  • The pathology, clinical manifestations and treatment of myoepithelioma are reviewed.
  • [MeSH-major] Lip Neoplasms / diagnosis. Myoepithelioma / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Reconstructive Surgical Procedures / methods. Salivary Glands, Minor. Surgical Flaps. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16099771.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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10. Prabhu S, Kaveri H, Rekha K: Benign, malignant salivary gland tumors: comparison of immunohistochemical expression of e-cadherin. Oral Oncol; 2009 Jul;45(7):594-9
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  • [Title] Benign, malignant salivary gland tumors: comparison of immunohistochemical expression of e-cadherin.
  • The aim of the present study was to assess any variation in the immunohistochemical expression of E-cadherin in benign and malignant salivary gland tumors.
  • A total of 60 cases of benign and malignant salivary gland tumors were evaluated immunohistochemically for E-cadherin expression.
  • These included 10 cases of pleomorphic adenoma (PA), 2 cases of canalicular adenoma (CA), 2 cases of myoepithelioma (MY), 24 cases of adenoid cystic carcinoma (ACC), 12 cases of mucoepidermoid carcinoma (MEC), 9 cases of adenocarcinoma (AC) and 1 case of carcinoma ex pleomorphic adenoma (Ca Ex PA).
  • 48 cases (80%) showed positive expression, in which benign tumors exhibited relatively increased reactivity (85.7%) as compared to the malignant tumors (78.3%).
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cadherins / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Case-Control Studies. Humans. Myoepithelioma / metabolism

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  • (PMID = 18955011.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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11. Otterbach F, Schmid KW: [Salivary gland-like tumors of the breast]. Pathologe; 2006 Sep;27(5):363-72
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  • [Title] [Salivary gland-like tumors of the breast].
  • A subset of rare benign and malignant breast tumors with and without myoepithelial differentiation are morphologically and histogenetically similar to salivary gland tumors, but may differ in incidence and clinical behavior.
  • The clinicopathological, immunohistochemical, molecular and prognostic features of ten salivary gland-like tumor entities of the breast are discussed and compared with their respective counterparts in the salivary glands.
  • [MeSH-major] Breast Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Cell Differentiation. Female. Humans. Myoepithelioma / pathology

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  • (PMID = 16896677.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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12. Seethala RR, LiVolsi VA, Zhang PJ, Pasha TL, Baloch ZW: Comparison of p63 and p73 expression in benign and malignant salivary gland lesions. Head Neck; 2005 Aug;27(8):696-702
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  • [Title] Comparison of p63 and p73 expression in benign and malignant salivary gland lesions.
  • In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors.
  • METHODS: The 95 salivary gland tumors were selected from the archives of the Department of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania.
  • RESULTS: In benign lesions, p63 and p73 nuclear reactivity was seen in 46 (92%) of 50 and 47 (94%) of 50 cases, respectively.
  • CONCLUSIONS: Hence, p63 and p73 expression is retained in both benign and malignant salivary gland tumors with basaloid or myoepithelial differentiation.
  • [MeSH-major] DNA-Binding Proteins / biosynthesis. Myoepithelioma / pathology. Nuclear Proteins / biosynthesis. Phosphoproteins / biosynthesis. Salivary Gland Neoplasms / pathology. Trans-Activators / biosynthesis

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 16021638.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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13. Perez DE, Lopes MA, de Almeida OP, Jorge J, Kowalski LP: Plasmacytoid myoepithelioma of the palate in a child. Int J Paediatr Dent; 2007 May;17(3):223-7
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  • [Title] Plasmacytoid myoepithelioma of the palate in a child.
  • BACKGROUND: Myoepithelioma is a rare benign salivary gland tumour, localized most frequently in the parotid and in minor intraoral salivary glands.
  • There have been only four cases of myoepithelioma in children and adolescents reported in the English-language literature, all of them involving the plasmacytoid variant.
  • The diagnosis was consistent with myoepithelioma, plasmocytoid variant.
  • CONCLUSION: Myoepithelioma is a very rare tumour in children and apparently presents a good prognosis, similar to occur in adult patients.

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  • (PMID = 17397468.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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14. He ZX, Li YN, Liu LK, He HW, Wang D: [Expression of deltaNp63 in salivary gland tumours]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 Jan;37(1):126-8
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  • [Title] [Expression of deltaNp63 in salivary gland tumours].
  • OBJECTIVE: To detect the expression of deltaNp63 in human salivary gland tumor and analyze its role in the malignant salivary gland tumors.
  • METHODS: Collecting the samples from 68 cases of pathologically proven salivary gland tumours and investigating the microscopic sections with HE stain and immunohistochemical-SP stain.
  • RESULTS: It was found that the expression of deltaNp63 is gradually increased in the malignant tumours, the myoepithelial cells and the basal cells of the salivary gland tumors are positive, and the expression of deltaNp63 is correlated directly with benign and malignant tumor.
  • CONCLUSION: deltaNp63 plays an important role in salivary gland tumours. deltaNp63 possesses some special activity that is characteristic of oncogene. p63 is a sensitive and highly specific marker of myoepithelial cells in salivary gland tumours and an additional marker for defining myoepithelial histogenesis. p63 is of definite clinical value in falicitating diagnosis and differential diagnosis.
  • [MeSH-major] Cystadenocarcinoma / metabolism. DNA-Binding Proteins / biosynthesis. Myoepithelioma / metabolism. Salivary Gland Neoplasms / metabolism. Trans-Activators / biosynthesis. Tumor Suppressor Proteins / biosynthesis

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  • (PMID = 16468660.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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15. Sassano P, Paparo F, Ramieri V, Colangeli W, Verdino G: Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland. Med Hypotheses; 2007;68(2):314-7
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  • [Title] Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland.
  • Myoepithelioma is a rare benign neoplasm of the salivary glands occurring more frequently in the parotids.
  • Moreover, it has been discussed the possible role of IL-6 as a modulating factor either in proliferation or in differentiation of pleomorphic adenoma cell line into myoepithelioma.
  • The authors present a rare case of parotid myoepithelioma occurred in a patient affected by myasthenia gravis and suppose a possible IL-6 mediated relationship between myasthenia gravis and parotid myoepithelioma.
  • [MeSH-major] Interleukin-6 / physiology. Myasthenia Gravis / physiopathology. Myoepithelioma / physiopathology. Parotid Neoplasms / physiopathology

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  • (PMID = 16997495.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Interleukin-6
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16. Nakaya K, Oshima T, Watanabe M, Hidaka H, Kikuchi T, Higashi K, Honkura Y, Hara Y, Kobayashi T: A case of myoepithelioma of the nasal cavity. Auris Nasus Larynx; 2010 Oct;37(5):640-3
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  • [Title] A case of myoepithelioma of the nasal cavity.
  • Myoepithelioma is a rare tumor, most frequently located in the salivary gland.
  • Case reports of extra-salivary myoepithelioma are sporadic, with only one case in the nasal cavity.
  • A 68-year-old male patient presented with a myoepithelioma of the nasal cavity manifesting as nasal obstruction and epistaxis, which was treated successfully with endoscopic excision.
  • Histological examination revealed myoepithelial cells and myxoid stroma, which confirmed the diagnosis of myoepithelioma.
  • The behavioral pattern is similar to if not identical with that of the mixed tumor, pleomorphic adenoma, which is benign, but the potential for recurrence is always present, especially if complete resection is not achieved.
  • [MeSH-major] Myoepithelioma / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20392578.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Das DK, Haji BE, Ahmed MS, Hossain MN: Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. Acta Cytol; 2005 Jan-Feb;49(1):65-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report.
  • BACKGROUND: Myoepithelioma is a rare, benign tumor of the salivary gland, most commonly affecting the parotid gland.
  • Although the cytologic features of myoepithelioma are documented in a few case reports, it has rarely been diagnosed preoperatively by fine needle aspiration (FNA) cytology.
  • A cytodiagnosis of myoepithelioma was given and corroborated by immunocytochemical staining, which revealed a positive reaction for vimentin, smooth muscle actin and S-100 protein.
  • Histopathology of the resected tumor and immunohistochemical staining confirmed the cytodiagnosis of myoepithelioma.
  • CONCLUSION: FNA cytologic features together with immunocytochemical studies on smears can offer a preoperative diagnosis of myoepithelioma.
  • [MeSH-major] Myoepithelioma / diagnosis. Myoepithelioma / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • (PMID = 15717758.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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18. Bień S, Kamiński B, Kopczyński J, Sygut J: [The synchroneous tumors of different histopathology in the parotid salivary gland]. Otolaryngol Pol; 2006;60(5):703-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The synchroneous tumors of different histopathology in the parotid salivary gland].
  • Ipsilateral salivary gland tumors of different histological types are very rare.
  • In 5 cases pleomorphic adenoma was one of synchronous tumor--in 2 cases with adenocarcinoma and in single cases with salivary duct carcinoma, adenolymphoma, and myoepithelioma.
  • Following the review of literature concerning the problem, two concepts has been critically discussed--the real synchronous occurrence of two different tumors, and transformation of benign tumor of salivary neoplasm to its malignant form.

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  • (PMID = 17263242.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 24
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19. Siddaraju N, Badhe BA, Goneppanavar M, Mishra MM: Preoperative fine needle aspiration cytologic diagnosis of spindle cell myoepithelioma of the parotid gland: a case report. Acta Cytol; 2008 Jul-Aug;52(4):495-9
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  • [Title] Preoperative fine needle aspiration cytologic diagnosis of spindle cell myoepithelioma of the parotid gland: a case report.
  • BACKGROUND: There are only rare case reports of preoperative fine needle aspiration cytologic (FNAC) diagnosis of myoepithelioma of the salivary gland.
  • Myoepitheliomas with pure spindle cell morphology may simulate a variety of benign or malignant spindle cell soft tissue tumors.
  • The clinical diagnosis was parotid malignancy.
  • However, based on the characteristic findings of the May-Grünwald-Giemsa (MGG)-stained smears, a preoperative diagnosis of myoepithelioma was made and confirmed by subsequent histopathologic examination and immunohistochemistry.
  • CONCLUSION: Cytologically, spindle cell myoepithelioma of the salivary gland may simulate low-grade spindle cell soft tissue sarcoma or schwannoma.
  • However, optimal sampling of the lesion and logical interpretation of the MGG-stained smears, in the appropriate clinical situation, allow a confident preoperative diagnosis of these tumors.
  • [MeSH-major] Myoepithelioma / pathology. Neurilemmoma / pathology. Parotid Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Coloring Agents. Diagnosis, Differential. Eosine Yellowish-(YS). Female. Humans. Immunohistochemistry. Methylene Blue. Middle Aged. Preoperative Care. Staining and Labeling / methods

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  • (PMID = 18702373.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / May-Grunwald Giemsa; T42P99266K / Methylene Blue; TDQ283MPCW / Eosine Yellowish-(YS)
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20. Queimado L, Lopes CS, Reis AM: WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. Genes Chromosomes Cancer; 2007 Mar;46(3):215-25
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  • [Title] WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors.
  • Here we report the identification of the WNT inhibitory factor 1 (WIF1) gene as a novel HMGA2 fusion partner in a salivary gland pleomorphic adenoma.
  • In normal salivary gland tissue WIF1 is expressed at a high level and HMGA2 is not expressed.
  • We screened 13 additional benign and malignant salivary gland tumors and detected WIF1 rearrangement in one out of two carcinomas ex-pleomorphic adenoma analyzed.
  • In transgenic mouse models, Wnt activation leads to a high frequency of benign and malignant salivary gland tumors.
  • To our knowledge, this is the first report suggesting that WIF1 is a recurrent target in human salivary gland oncogenesis and that downregulation of WIF1 plays a role in the development and/or progression of pleomorphic adenomas.
  • [MeSH-major] Carrier Proteins / genetics. Repressor Proteins / genetics. Salivary Gland Neoplasms / genetics. Wnt Proteins / physiology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Alleles. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / metabolism. Chromosome Aberrations. Chromosomes, Human, Pair 12 / genetics. Gene Expression Regulation, Neoplastic. HMGA2 Protein / genetics. HMGA2 Protein / metabolism. Humans. Myoepithelioma / genetics. Myoepithelioma / metabolism. Myoepithelioma / pathology. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Salivary Glands / metabolism. Signal Transduction

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17171686.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR018741
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / HMGA2 Protein; 0 / Oncogene Proteins, Fusion; 0 / Repressor Proteins; 0 / WIF1 protein, human; 0 / Wnt Proteins
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21. Meer S, Altini M: CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology; 2007 Jul;51(1):26-32
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  • [Title] CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia.
  • AIMS: To evaluate cytokeratin (CK) 7/20 expression patterns in salivary gland neoplasia.
  • METHODS AND RESULTS: Formalin-fixed paraffin embedded tissue from 153 salivary gland tumours were evaluated for CK7/20 immunoreactivity.
  • The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepidermoid carcinoma (n = 21), polymorphous low-grade adenocarcinoma (n = 21), carcinoma ex-pleomorphic adenoma (n = 11), acinic cell carcinoma (n = 17), epimyoepithelial carcinoma (n = 7), oncocytic carcinoma (n = 3), hyalinizing clear cell carcinoma (n = 1), papillary cystadenocarcinoma (n = 1), salivary duct carcinoma (n = 3), adenocarcinoma (not otherwise specified) (n = 4) and squamous carcinoma (n = 4).
  • All salivary gland neoplasms showed a CK7+/CK20- immunoprofile ranging from 5 to 100%.
  • CONCLUSIONS: Although the CK7/20 immunoprofile is not useful in distinguishing the various types of salivary gland neoplasms or between benign and malignant salivary gland tumours, it may facilitate differentiation of primary salivary gland neoplasia from metastatic tumours and squamous carcinoma, and the diagnosis of metastatic salivary gland tumours.
  • [MeSH-major] Gene Expression Profiling. Keratin-20 / metabolism. Keratin-7 / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Salivary Glands / metabolism. Salivary Glands / pathology

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  • (PMID = 17593078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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22. Vékony H, Röser K, Löning T, Raaphorst FM, Leemans CR, Van der Waal I, Bloemena E: Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands. Histopathology; 2008 Dec;53(6):658-66
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  • [Title] Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands.
  • AIMS: Myoepithelial salivary gland tumours are uncommon and follow an unpredictable biological course.
  • METHODS AND RESULTS: Expression of protein (E2F1, p16(INK4a), p53, cyclin D1, Ki67 and Polycomb group proteins BMI-1, MEL-18 and EZH2) was investigated in 49 benign and 30 primary malignant myoepithelial tumours and five histologically benign recurrences by immunohistochemistry and the findings correlated with histopathological characteristics.
  • Benign tumours showed a higher percentage of cells with expression of p16(INK4a) pathway members [p16(INK4a) and E2F1 (both P < 0.001), and cyclin D1, P = 0.002] compared with normal salivary gland.
  • Recurrences displayed more p53 + tumour cells (P = 0.02) than benign primaries.
  • Amongst the benign tumours, the clear cell type had the highest proliferation fraction (P = 0.05) and a higher percentage of EZH2 was detected in the plasmacytoid cell type (P = 0.002).
  • We propose that additional inactivation of p53 in malignant primaries and benign recurrences contributes to myoepithelial neoplastic transformation and aggressive tumour growth.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Myoepithelioma / metabolism. Salivary Gland Neoplasms / metabolism. Signal Transduction. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Gene Expression. Humans. Immunohistochemistry. Middle Aged. Salivary Glands / pathology. Young Adult

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  • (PMID = 19076682.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p53
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23. Khademi B, Kazemi T, Bayat A, Bahranifard H, Daneshbod Y, Mohammadianpanah M: Salivary gland myoepithelial neoplasms: a clinical and cytopathologic study of 15 cases and review of the literature. Acta Cytol; 2010 Nov-Dec;54(6):1111-7
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  • [Title] Salivary gland myoepithelial neoplasms: a clinical and cytopathologic study of 15 cases and review of the literature.
  • OBJECTIVE: To describe the clinical and cytopathologic findings in 15 cases of salivary gland myoepithelial neoplasms and to assess the value of fine needle aspiration in the diagnosis of these tumors.
  • STUDY DESIGN: Between 2000 and 2007, 15 consecutive patients were diagnosed with benign and malignant myoepithelioma of the head and neck region.
  • A literature review of PubMed using the search terms myoepithelioma, myoepithelial carcinoma and salivary gland was performed.
  • Parotid gland consisted of 73% of all primary sites.
  • There were 10 benign and 5 malignant myoepitheliomas.
  • In the benign group, only in 1 case did fine needle aspiration (FNA) revealed benign spindle cell variant, and in others, FNA diagnosis was mixed tumor.
  • Similarly, in the malignant group, FNA diagnosis was malignant in only I case.
  • The predominant cell morphology in the benign group was plasmacytoid cells, followed by a spindle and clear cell population.
  • Scant fibrillary myxoid material was observed in both benign and malignant specimens.
  • In the literature review and by analyzing the pooled data from 24 major reported series including 601 patients, the mean age at diagnosis was 51 years, and the mean male/female ratio was 1/.01.
  • In addition, 39% of all tumors were malignant, and parotid gland consisted of 45% of all primary sites.
  • CONCLUSION: According to the findings of the present study and review of the literature, the cytologic criteria for preoperative diagnosis ofsalivary gland myoepithelial neoplasms remain unsatisfactory and need to be clarified.
  • [MeSH-major] Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 21428157.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Laikui L, Hongwei L, Hongbing J, Zhixiu H: Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases. J Oral Pathol Med; 2008 Apr;37(4):201-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases.
  • OBJECTIVE: Determine the clinical and histopathologic features of epithelial salivary gland tumors of children and adolescents.
  • METHODS: A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files.
  • RESULTS: Sixty tumors (75.9%) were benign and 19 (24.1%) malignant.
  • PA was the most common type of benign tumor.
  • Five patients with parotid PA and two cases with palate myoepithelioma showed local recurrences.
  • CONCLUSIONS: Our data showed that the salivary gland tumors in children and adolescents may be the higher incidence of benign tumors, especially of PA; the slightly higher tendency for female predominance; the higher incidence of parotid glands.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. China. Female. Humans. Infant. Male. Myoepithelioma / pathology. Retrospective Studies

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  • (PMID = 18205745.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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25. Pacchioni D, Volante M, Casetta G, Sapino A, Marchiò C, Bussolati G: Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case. Am J Surg Pathol; 2007 Apr;31(4):632-6
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  • [Title] Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case.
  • The lesion morphologically resembled a pleomorphic adenoma of the salivary gland.
  • The tumor proved benign at follow-up.
  • [MeSH-major] Kidney Neoplasms / pathology. Myoepithelioma / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Salivary Gland Neoplasms / pathology

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  • (PMID = 17414112.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. Pelosi G, Rodriguez J, Viale G, Rosai J: Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association. Am J Surg Pathol; 2006 Mar;30(3):375-87
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  • [Title] Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association.
  • Reported is a hitherto unrecognized association of pulmonary hamartomas with salivary gland-type tumors showing myoepithelial differentiation, namely, a case of myoepithelioma arising in a otherwise classic hamartoma with cartilage predominance, and a case of malignant mixed tumor arising in a predominantly fibrous hamartoma resembling müllerian adenofibroma.
  • The myoepithelioma patient was well with no signs of recurrent disease at 6-month clinical control, but she was then lost to follow-up; the malignant mixed tumor patient is alive and well after 6 months since operation.
  • The lack of individual cell necrosis, mitotic activity, cell atypia, and pulmonary parenchyma infiltration supported a diagnosis of benign or unproven malignant potential tumor for the myoepithelioma, whereas the reverse held true for the other tumor in which the diagnosis of malignant mixed tumor of the lung was rendered.
  • Their main importance of recognizing this association lies in separating these tumors histologically from other monophasic or biphasic tumors, either primary or secondary, such as pulmonary sarcomatoid carcinomas or true sarcomas, and metastatic salivary gland tumors, spindle cell carcinomas, melanomas, and soft tissue and visceral sarcomas.
  • [MeSH-major] Hamartoma / pathology. Lung Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Myoepithelioma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Biopsy, Needle. Cell Transformation, Neoplastic. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lung Diseases / metabolism. Lung Diseases / pathology. Lung Diseases / surgery. Salivary Glands / pathology

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  • (PMID = 16538059.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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27. Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N: Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol; 2005 Aug;41(7):716-22
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  • [Title] Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors.
  • We examined the expression of Centromere protein F (CENP-F) mRNA in 26 human salivary gland tumors (seven pleomorphic adenomas, three Warthin tumors, seven mucoepidermoid carcinomas, four adenoid cystic carcinomas, four acinic cell carcinomas and one malignant myoepithelioma) and four normal submandibular glands using the real time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
  • The mean expression level of CENP-F mRNA was higher in malignant tumors (1.05+/-0.32) than normal submandibular glands (0.11+/-0.05) and benign tumors (0.46+/-0.16).
  • [MeSH-major] Adenoma / genetics. Chromosomal Proteins, Non-Histone / genetics. Gene Expression Regulation, Neoplastic / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Female. Humans. Male. Microfilament Proteins. Middle Aged. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Submandibular Gland / metabolism

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  • (PMID = 15927522.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / Microfilament Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / centromere protein F
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28. Wang D, Li Y, He H, Liu L, Wu L, He Z: Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jul;104(1):94-100
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  • [Title] Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases.
  • OBJECTIVES: This study aimed to investigate the diverse histopathological types and distribution characteristics of epithelial minor salivary gland tumors (MSGTs) in a Chinese population.
  • RESULTS: A total of 737 epithelial MSGTs, consisting of 340 (46.1%) benign and 397 (53.9%) malignant tumors, were confirmed in 381 males and 356 females.
  • The average age of patients with benign and malignant tumors was 40.7 and 49.4 years, respectively.
  • Pleomorphic adenoma (PA) (81.8%) and adenoid cystic carcinoma (ACC) (36.0%) were the most frequent types in benign and malignant tumors, respectively.
  • CONCLUSIONS: Comparing with reports from other countries, it is suggested that the MSGTs in this southwest Chinese population may be characterized by a higher incidence of MSGTs than in the other reviewed countries, higher incidence of malignant than benign MSGTs, absence of canalicular adenoma (CA) occurrence, and a higher incidence of myoepithelioma (MEO).
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology. Salivary Glands, Minor

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  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Feb;105(2):136-8 [18230384.001]
  • (PMID = 17577550.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Gama-de-Souza LN, Cyreno-Oliveira E, Freitas VM, Melo ES, Vilas-Boas VF, Moriscot AS, Jaeger RG: Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin. Matrix Biol; 2008 Jun;27(5):402-19
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  • [Title] Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin.
  • We studied the induction of protease activity by the laminin alpha1-derived peptide AG73 in cells from adenoid cystic carcinoma (CAC2) and myoepithelioma (M1), respectively a malignant and a benign salivary gland tumors.
  • Laminin alpha1 chain and MMP9 were immunolocalized in adenoid cystic carcinoma and myoepithelioma in vivo and in vitro.
  • [MeSH-major] Antigens, CD29 / metabolism. Laminin / pharmacology. Matrix Metalloproteinases / metabolism. Peptide Fragments / pharmacology. Salivary Gland Neoplasms / pathology. Syndecan-1 / metabolism
  • [MeSH-minor] Blotting, Western. Calcium / metabolism. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cell Adhesion / drug effects. Cell Line, Tumor. Chelating Agents / pharmacology. Dipeptides / pharmacology. Extracellular Matrix / drug effects. Extracellular Matrix / metabolism. Heparin / pharmacology. Humans. Immunohistochemistry. Matrix Metalloproteinase 2 / genetics. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / genetics. Matrix Metalloproteinase 9 / metabolism. Matrix Metalloproteinase Inhibitors. Myoepithelioma / genetics. Myoepithelioma / metabolism. Myoepithelioma / pathology. RNA, Small Interfering / genetics. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / physiology

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  • (PMID = 18378436.001).
  • [ISSN] 0945-053X
  • [Journal-full-title] Matrix biology : journal of the International Society for Matrix Biology
  • [ISO-abbreviation] Matrix Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / AG 73; 0 / Antigens, CD29; 0 / Chelating Agents; 0 / Dipeptides; 0 / Laminin; 0 / Matrix Metalloproteinase Inhibitors; 0 / N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide; 0 / Peptide Fragments; 0 / RNA, Small Interfering; 0 / SDC1 protein, human; 0 / Syndecan-1; 151186-83-3 / laminin A; 9005-49-6 / Heparin; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / MMP2 protein, human; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; SY7Q814VUP / Calcium
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30. Kern MA, Kasper HU, Drebber U, Guntinas-Lichius O, Veelken F, Ortmann M: [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component]. Laryngorhinootologie; 2005 Jun;84(6):432-5
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  • [Title] [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component].
  • Myoepitheliomas of the salivary glands are rare benign tumors composed of spindle-shaped myoepithelial cells, but may show plasmacytoid, epitheloid and clear cell-types that principally exhibit myoepithelial but not ductal differentiation.
  • These tumors are mainly located in the major salivary glands and have sometimes abundant, acellular, mucoid or hyaline stroma but lack chondroid and myxochondroid foci, probably representing the one end of the spectrum of pleomorphic adenoma.
  • Lipomatosis in the form of isolated small islands or scattered single lipocytes, is quite uncommon, and a large amount of adipose tissue in a pleomorphic adenoma and myoepithelioma is a rarity and only described in major salivary glands.
  • We present the case report of a 38-year old man with a myoepithelioma of the minor palatinal salivary glands with extensive lipomatosis as an example of this rare phenomena.
  • [MeSH-major] Lipomatosis / pathology. Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology. Uvula / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male

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  • (PMID = 15940575.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Vékony H, Röser K, Löning T, Ylstra B, Meijer GA, van Wieringen WN, van de Wiel MA, Carvalho B, Kok K, Leemans CR, van der Waal I, Bloemena E: Copy number gain at 8q12.1-q22.1 is associated with a malignant tumor phenotype in salivary gland myoepitheliomas. Genes Chromosomes Cancer; 2009 Feb;48(2):202-12
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  • [Title] Copy number gain at 8q12.1-q22.1 is associated with a malignant tumor phenotype in salivary gland myoepitheliomas.
  • Salivary gland myoepithelial tumors are relatively uncommon tumors with an unpredictable clinical course.
  • We set out to delineate known chromosomal aberrations in more detail and to unravel chromosomal differences between benign myoepitheliomas and myoepithelial carcinomas.
  • Both benign and malignant tumors revealed a limited amount of chromosomal alterations (median of 5 and 7.5, respectively).
  • Cluster 1 contained a mixture of the two phenotypes (n = 10), cluster 2 included mostly benign tumors (n = 10), and cluster 3 only contained carcinomas (n = 7).
  • Supervised analysis between malignant and benign tumors revealed a 36 Mbp-region at 8q being more frequently gained in malignant tumors (P = 0.007, FDR = 0.05).
  • This is the first study investigating genomic differences between benign and malignant myoepithelial tumors of the salivary glands at a genomic level.
  • Both unsupervised and supervised analysis of the genomic profiles revealed chromosome arm 8q to be involved in the malignant phenotype of salivary gland myoepitheliomas.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8 / genetics. Gene Dosage. Myoepithelioma / genetics. Salivary Gland Neoplasms / genetics

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  • (PMID = 19009612.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins
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32. Neves Cde O, Soares AB, Costa AF, de Araujo VC, Furuse C, Juliano PB, Altemani A: CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms. Appl Immunohistochem Mol Morphol; 2010 Mar;18(2):172-8
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  • [Title] CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms.
  • In salivary glands, expression of CD10 has only been used to identify neoplastic myoepithelial cells of pleomorphic adenomas and myoepithelial carcinomas.
  • However, its accuracy in other salivary tumors with myoepithelial component has yet to be analyzed.
  • We examined 72 salivary tumors with myoepithelial differentiation using immunohistochemical technique to detect CD10.
  • In salivary glands, CD10 expression was not detected in myoepithelial cells.
  • In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms.
  • In conclusion, salivary neoplastic myoepithelial cells gain CD10 expression in relation to their normal counterparts.
  • The high expression of CD10 by this carcinoma can be a valuable tool to separate EMEC from the tubular variant of adenoid cystic carcinomas in small incisional biopsies, where the precise diagnosis may be impossible.

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  • (PMID = 19752720.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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33. Sun G, Yang X, Tang E, Wen J, Lu M, Hu Q: The treatment of sublingual gland tumours. Int J Oral Maxillofac Surg; 2010 Sep;39(9):863-8
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  • [Title] The treatment of sublingual gland tumours.
  • This study assessed the clinical and histological features and therapeutic efficacy of 25 cases of sublingual gland tumours from 1998 to 2008.
  • 4 cases were benign tumours (16%).
  • 21 cases were malignant sublingual gland tumours (84%) and of these, 18 were adenoid cystic carcinoma (86%).
  • Adenoid cystic carcinoma was mainly of the histological type, and the other histological classifications included mucoepidermoid carcinoma, pleomorphic adenoma, myoepithelioma, oncocytoma and polymorphous low-grade adenocarcinoma.
  • Sublingual gland tumours are rare and most are malignant.
  • For malignant sublingual gland tumours, early diagnosis and aggressive surgical treatment, especially for tumours with nerve involvement, is the key to improving prognosis.
  • For benign sublingual gland tumours, the resection of tumour and sublingual gland is the preferred treatment.
  • [MeSH-major] Carcinoma / therapy. Salivary Gland Diseases / pathology. Sublingual Gland / pathology. Sublingual Gland Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / therapy. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / therapy. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / therapy. Adult. Aged. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / therapy. Female. Humans. Male. Middle Aged. Myoepithelioma / pathology. Myoepithelioma / therapy. Reconstructive Surgical Procedures / methods

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  • [Copyright] Copyright © 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20605409.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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34. Maurer MH, Gartenschläger S, Dietrich C: Giant epithelial-myoepithelial carcinoma of the parotid gland. Clin Imaging; 2009 May-Jun;33(3):237-9
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  • [Title] Giant epithelial-myoepithelial carcinoma of the parotid gland.
  • Computed tomography (CT) demonstrated a cyst-like lesion that appeared to arise from the parotid gland.
  • Such rare carcinomas should be considered in the differential diagnosis of parotid gland malignancies.
  • We discuss the possibilities of imaging modalities such as CT and magnetic resonance imaging (MRI) in the differentiation between benign and malignant salivary gland tumors.
  • [MeSH-major] Myoepithelioma / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 19411033.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Buchner A, Merrell PW, Carpenter WM: Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med; 2007 Apr;36(4):207-14
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  • [Title] Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world.
  • BACKGROUND: The relative frequency of individual intra-oral minor salivary gland tumors (IMSGT) is not well documented in the literature.
  • Tumors were classified according to the 2005 WHO classification of salivary gland tumors.
  • Of the 380 tumors, 224 (59%) were benign and 156 (41%) were malignant.
  • Of the benign tumors, pleomorphic adenoma (PA) was the most common (39.2%), followed by cystadenoma (6.3%), canalicular adenoma (6.1%), ductal papillomas (4.4%), basal cell adenoma (1.6%), and myoepithelioma (1.3%).
  • To determine the true relative frequency, more studies should be conducted, on a large number of cases from one source, by experienced pathologists in the field of salivary gland tumors.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology. Salivary Glands, Minor / pathology

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  • (PMID = 17391298.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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36. Olejniczak I, Kozłowski Z, Dabrowska K, Lukomski M: [Tumors of the parotid gland--management and results of surgical treatment]. Otolaryngol Pol; 2008;62(4):446-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors of the parotid gland--management and results of surgical treatment].
  • INTRODUCTION: Tumors of the salivary glands are uncommon and represent 2-4% of head and neck neoplasms.
  • Most tumors originate in the parotid gland, from which 10 to 15% are found to be malignant.
  • MATERIAL AND METHODS: Retrospective analysis of the medical data of 138 patients with parotid gland tumors who where treated in our departament between 1997-2007 was done.
  • Benign tumors were found in 104 patients with the pleomorphic adenoma as the most common (53 cases).
  • The most frequent localization of the tumor after dividing the parotid gland into four parts was postero-inferior pole.
  • CONCLUSIONS: Frequency of tumors of the parotid gland, their histological types and methods of surgical treatment in our data support other studies.
  • Ultrasonography is the key procedure in the diagnosis of tumors of the parotid gland, qualification into surgical treatment and postoperative observation.
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / ultrasonography. Adult. Aged. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / ultrasonography. Female. Humans. Male. Middle Aged. Myoepithelioma / epidemiology. Myoepithelioma / ultrasonography. Poland. Retrospective Studies. Risk Factors. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 18837221.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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37. Pusztaszeri M, Braunschweig R, Mihaescu A: Pleomorphic adenoma with predominant plasmocytoid myoepithelial cells: a diagnostic pitfall in aspiration cytology. Case report and review of the literature. Diagn Cytopathol; 2009 Jan;37(1):56-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fine-needle aspiration (FNA) biopsy of the salivary gland is a sensitive and specific diagnostic tool.
  • However, diagnostic problems are sometimes encountered in interpreting some cases, not only in differentiating benign from malignant cases but also in the specific classification of these neoplasms.
  • We report a case of a pleomorphic adenoma with predominant plasmocytoid myoepithelial cells arising in minor salivary glands from the hard palate in a 78-year-old patient, which was falsely diagnosed as a carcinoma on liquid-based cytology (ThinPrep (TP)).
  • The differential diagnosis of salivary gland tumors with predominant myoepithelial cells on FNA biopsy is discussed.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Myoepithelioma / diagnosis. Myoepithelioma / pathology. Salivary Glands / pathology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18973130.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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38. Yu H, Liu D, Li C, Huang X, Zhong W: [Clinical application of postauricular muscular fasciae-periosteal flap and modified unwrinkle incision in parotidectomy]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2009 Oct;23(10):1167-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: From January 2006 to August 2008, 28 patients with benign lesions of parotid gland were treated.
  • There were 17 males and 11 females aged 19 to 79 years old (average 50 years old), including 20 cases of mixed tumor, 5 cases of adenolymphoma, 1 case of branchial cleft cyst, 1 case of eosinophilic hyperplastic lymphogranuloma, and 1 case of myoepithelioma.
  • Parotid gland and tumor mass were resected with postauricular incision hidden within the hairline, introcession defect (3.0 cm x 2.0 cm x 1.0 cm-3.5 cm x 2.5 cm x 1.5 cm) were repaired with simultaneously adopting postauricular muscular fasciae-periosteal flap (4.0 cm x 3.0 cm x 1.0 cm-5.0 cm x 4.0 cm x 1.5 cm) by turning the pedicle flap 180 degrees.
  • No salivary fistula, facial paralysis, and earlobe numbness occurred.
  • [MeSH-major] Fascia / transplantation. Parotid Gland / surgery. Parotid Neoplasms / surgery. Rhytidoplasty / methods

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  • (PMID = 19957830.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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39. Logasundaram R, Amarawickrama H, Premachandra D, Hellquist H: Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1563-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Carcinoma ex pleomorphic adenoma poses a challenge to diagnosis and treatment.
  • Herein we describe an extremely unusual case, which presented initially as an intracapsular carcinoma ex pleomorphic adenoma in the right parotid gland.
  • The first recurrence, after an interval of 8 years, showed only recurrence of the benign component.
  • This case report elucidates the atypical clinical behaviour and interesting histological features encountered within this group of salivary neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Myoepithelioma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18288478.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Chang T, Husain AN, Colby T, Taxy JB, Welch WR, Cheung OY, Early A, Travis W, Krausz T: Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation. Am J Surg Pathol; 2007 Apr;31(4):562-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pulmonary tumors with epithelial and myoepithelial differentiation are rare, thought to be of bronchial minor salivary gland origin and classified similarly to salivary gland neoplasms.
  • The biologic behavior to date has been benign.
  • This is the first reported series of a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation that differs histologically from all previously recognized pulmonary salivary gland-type and pneumocytic tumors.
  • It is a unique benign appearing neoplasm for which the designation pneumocytic adenomyoepithelioma is suggested.
  • [MeSH-major] Lung Neoplasms / pathology. Myoepithelioma / pathology

  • MedlinePlus Health Information. consumer health - Lung Cancer.
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  • (PMID = 17414103.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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