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1. Epivatianos A, Poulopoulos A, Kayavis I, Papanayotou P: Tumor-associated glycoprotein 72 (TAG-72) expression in salivary gland neoplasia: an immunohistochemical study using the monoclonal antibody (MAb) CC49. Oral Dis; 2000 Mar;6(2):112-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-associated glycoprotein 72 (TAG-72) expression in salivary gland neoplasia: an immunohistochemical study using the monoclonal antibody (MAb) CC49.
  • OBJECTIVES: The purpose of this study was to investigate immunohistochemically the expression of tumor-associated glycoprotein 72 (TAG-72) using the monoclonal antibody (MAb) CC49 in salivary gland neoplasia and normal salivary glands in an attempt to determine the potential usefulness of MAb CC49 in diagnostic and therapeutic applications.
  • MATERIALS AND METHODS: Eighty-six specimens (21 benign tumors, 41 malignant, and 24 normal salivary glands), fixed in 10% formalin and embedded in paraffin, were retrieved from the files of the Department of Oral Medicine and Oral Pathology at the Dental School of Aristotle University, Thessaloniki, Greece, and were retrospectively studied with hematoxylin and eosin and with the streptavidin-biotin-complex method using the MAb CC49.
  • RESULTS: Strong immunoreactivity for TAG-72 was observed in salivary duct carcinoma, adenocarcinoma, papillary cystadenocarcinoma, low-grade mucoepidermoid carcinoma, normal submandibular, sublingual, and minor salivary glands.
  • [MeSH-major] Antibodies, Monoclonal. Antibodies, Neoplasm. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Glycoproteins / analysis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Carcinoma / genetics. Carcinoma / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / pathology. Coloring Agents. Cystadenocarcinoma, Papillary / genetics. Cystadenocarcinoma, Papillary / pathology. Eosine Yellowish-(YS). Fluorescent Dyes. Gene Expression Regulation, Neoplastic. Hematoxylin. Humans. Immunoenzyme Techniques. Immunohistochemistry. Parotid Gland / cytology. Parotid Gland / metabolism. Retrospective Studies. Salivary Glands / cytology. Salivary Glands / metabolism. Salivary Glands, Minor / cytology. Salivary Glands, Minor / metabolism. Sublingual Gland / cytology. Sublingual Gland / metabolism. Submandibular Gland / cytology. Submandibular Gland / metabolism

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  • (PMID = 10702789.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / B72.3 antibody; 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Fluorescent Dyes; 0 / Glycoproteins; 0 / tumor-associated antigen 72; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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2. Vuhahula EA: Salivary gland tumors in Uganda: clinical pathological study. Afr Health Sci; 2004 Apr;4(1):15-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SETTING: Makerere University, Faculty of Medicine, Department of Pathology.
  • METHODS: All epithelial tumors from major and minor salivary glands accessioned from 1979 to 1988 were analyzed in respect to sex and age of patients, anatomical location of the tumor and histological type.
  • The histological diagnosis of each individual tumor was based on the 1991 WHO classification of salivary gland tumors.
  • No tumor was implicated from the sublingual gland.
  • There were a total of 125 (46.6%) malignant tumors and 143 (53.4%) benign tumors.
  • The mean age of patients with malignant lesions (43.1 years; SD=16.75; median=44.00 years) was 9.6 years older than those with benign tumors (mean=33.5 years; SD=16.0; median=30.00 years).
  • Pleomorphic adenoma was the most common benign tumor (74.8%), followed by myoepithelioma (9.8%).
  • No Whartin's tumor was encountered.
  • The malignant tumors were dominated by adenoid cystic carcinoma (28.8%) followed by mucoepidermoid carcinoma (21.6%).
  • i) females are more affected than males, ii) there is a low proportion of tumors from the parotid gland and high proportion of tumors from the submandibular and minor salivary glands, iii) the parotid and minor salivary gland tumors have more probability of being malignant than those tumors from the submandibular gland iv) the newly categorized pathological entities are common and v) Whartin's tumor is extremely rare in black African population.

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  • (PMID = 15126188.001).
  • [ISSN] 1729-0503
  • [Journal-full-title] African health sciences
  • [ISO-abbreviation] Afr Health Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Uganda
  • [Other-IDs] NLM/ PMC2141656
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3. Robinson JW, Brownstein S, Jordan DR, Hodge WG: Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. Surv Ophthalmol; 2006 Sep-Oct;51(5):513-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature.
  • Invasive mucoepidermoid carcinoma of the conjunctiva of the left lower eyelid was diagnosed in an orbital exenteration specimen of a 57-year-old woman, after a biopsy of the same lesion was originally diagnosed as invasive squamous cell carcinoma.
  • The tumor invaded the cornea, sclera, lacrimal gland, regional small nerves, and lymphatics, but did not show intraocular involvement.
  • The original biopsy specimen was reassessed with stains for mucin and found to be mucoepidermoid carcinoma of the conjunctiva.
  • We reviewed 21 cases of mucoepidermoid carcinoma of the conjunctiva described to date in the English literature.
  • Evaluating suspected aggressive squamous cell carcinoma with special stains for mucin generally helps to identify mucoepidermoid carcinoma of the conjunctiva.
  • More extensive surgical excision than that used for squamous cell carcinoma should be implemented in the management of mucoepidermoid carcinoma of the conjunctiva to prevent recurrence.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Conjunctival Neoplasms / pathology. Conjunctivitis / complications. Pemphigoid, Benign Mucous Membrane / complications
  • [MeSH-minor] Basement Membrane / pathology. Biopsy. Drug Therapy, Combination. Female. Fluorometholone / therapeutic use. Humans. Middle Aged. Mitomycin / therapeutic use. Neoplasm Invasiveness. Ofloxacin / therapeutic use


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4. Wakasa T, Higuchi Y, Hisatomi M, Aiga H, Honda Y, Kishi K: Application of dynamic CT for various diseases in the oral and maxillofacial region. Eur J Radiol; 2002 Oct;44(1):10-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate whether dynamic CT enables quantitative differentiation between inflammation, benign tumors, and malignant tumors in oral and maxillofacial regions.
  • METHODS: Sixteen malignant tumors (14 squamous cell Ca, one adenoid cystic Ca, one mucoepidermoid Ca), six benign tumors (one Warthin tumor, two pleomorphic adenomas, one lipoma, one Schwanoma, one hemangioma), and seven inflammation cases (three submandibular adenitis, two osteomyelitis, two perimandibular inflammations) were examined.
  • Contrast agent (0.8 ml/kg) was injected intravenously at 5 ml/s.
  • Parameters from the time-density curve were investigated: peak height (PH), relative CT value from the base CT value when the curve reached peak point; peak time (PT), the time when the curve reaches the peak point from contrast medium infusion; transit time (TT), time between two transit points on the time-density curve; and peak time ratio (PR), the ratio of peak time from the lesion to the artery and peak time from the vein to the artery.
  • RESULTS: PH was highest in inflammation, followed by malignant tumors and benign tumors.
  • TT was significantly longer in benign tumor cases compared with malignant tumor and inflammation cases.
  • PR for malignant tumor and inflammation were between the artery and vein phase, and that for benign tumor was beyond the vein phase.

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  • (PMID = 12350403.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
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