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1. Torres-Domingo S, Bagan JV, Jiménez Y, Poveda R, Murillo J, Díaz JM, Sanchis JM, Gavaldá C, Carbonell E: Benign tumors of the oral mucosa: a study of 300 patients. Med Oral Patol Oral Cir Bucal; 2008 Mar;13(3):E161-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign tumors of the oral mucosa: a study of 300 patients.
  • OBJECTIVES: To analyze the frequency and type of the most common benign tumors of the oral mucosa found at the Hospital Stomatology Service, and to study the clinical characteristics and possible etiological factors.
  • MATERIAL AND METHODS: This is a retrospective study of 300 patients with histologically diagnosed benign tumors of the oral mucosa.
  • Data was compiled for each case, documenting information relating to age, gender, medication, habits (smoking, oral hygiene), anamnesis (reason for consultation, symptomatology, evolution), and the characteristics of the lesion (site, color, size, surface, consistency, and base).
  • RESULTS: Of all the tumors studied, 53% were histologically diagnosed as fibroma.
  • In the study of prevalence of benign tumors of the oral mucosa, no differences were found for age; however there were differences according to gender, finding a greater prevalence of fibromas, pyogenic granulomas, and giant cell granulomas in women, at a ratio of 2:1.
  • The group of tumors studied showed a significantly asymptomatic behaviour, and self-limiting and slow growth.
  • CONCLUSIONS: Following the study of 300 patients histologically diagnosed with benign tumor of the oral mucosa, we can state that with regard to prevalence, we found significant differences with respect to gender, being more frequent in women.
  • The fibroma is the most frequent benign tumor of the oral cavity.
  • [MeSH-major] Mouth Mucosa. Mouth Neoplasms

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  • (PMID = 18305435.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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2. Diniz MB, Giro Elisa MA, Zuanon Angela CC, Costa CA, Hebling J: Congenital epulis: a rare benign tumor in the newborn. J Indian Soc Pedod Prev Dent; 2010 Jul-Sep;28(3):230-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital epulis: a rare benign tumor in the newborn.
  • Congenital epulis (CE) of the newborn is a rare benign soft tissue tumor that presents at birth.
  • This condition may interfere with respiration, feeding or adequate closure of the mouth.
  • A decisive diagnosis is made by histopathologic analysis as other newborn lesions can be incorrectly diagnosed as CE.
  • [MeSH-major] Gingival Neoplasms / congenital. Gingival Neoplasms / pathology

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  • (PMID = 21157060.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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3. Ueno S, Hirakawa H, Matsuda H, Tei E, Kaneko A, Ohta Y, Kajiwara H: A case of neonatal mature teratoma transformed to malignancy in the neck extending to the mouth floor. Tokai J Exp Clin Med; 2009 Dec;34(4):130-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of neonatal mature teratoma transformed to malignancy in the neck extending to the mouth floor.
  • The case is a full-term baby girl with swallowing difficulty and has a mass at the floor of her mouth with the right neck swelling.
  • Puncture and marsupialisation of the cyst could not relieve her symptom and the tumor was resected in three occasions and was diagnosed as mature teratoma without malignant component.
  • Biopsied specimen demonstrated the mass to be germ cell tumor with embryonal carcinoma and yolk sac tumor component.
  • Head and neck teratomas in children are mostly benign amenable to curative excision but its rarity and site and size of the tumor make its treatment challenging.
  • There exists a relationship between the age at diagnosis and outcome of a patient with teratoma and head and neck teratomas in neonate are mostly benign but should be removed completely as soon as the patient condition is stabilized to reduce the risk of malignant change.
  • [MeSH-major] Cell Transformation, Neoplastic. Head and Neck Neoplasms / secondary. Mouth Floor / pathology. Mouth Neoplasms / secondary. Teratoma / pathology

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  • (PMID = 21319013.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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4. Nikitakis NG, Argyris P, Sklavounou A, Papadimitriou JC: Oral myoepithelioma of soft tissue origin: report of a new case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Nov;110(5):e48-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral myoepithelioma of soft tissue origin: report of a new case and literature review.
  • Oral myoepithelioma of soft tissue origin, an entity distinct from myoepithelioma of salivary glands, constitutes an extremely rare benign neoplasm, with only 1 previously published case, affecting the tongue of a 22-year-old woman.
  • Ectomesenchymal chondromyxoid tumour (ECT) also is a very rare benign neoplasm of the oral cavity that has a strong predilection for the anterior dorsum of the tongue.
  • A review of the relevant literature is made and the relationship between oral STM and ECT discussed.
  • [MeSH-major] Myoepithelioma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Antigens, CD57 / analysis. Cell Nucleus / ultrastructure. Chromatin / ultrastructure. Cytoplasm / ultrastructure. Desmin / analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Muscle, Skeletal / pathology. Neoplasms, Complex and Mixed / diagnosis. S100 Proteins / analysis. Vimentin / analysis

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20955943.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD57; 0 / Chromatin; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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5. Torrijos-Aguilar A, Alegre-de Miquel V, Pitarch-Bort G, Mercader-García P, Fortea-Baixauli JM: [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases]. Actas Dermosifiliogr; 2009 Mar;100(2):126-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases].
  • [Transliterated title] Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos.
  • BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells.
  • OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature.
  • METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases).
  • The most common site was the oral cavity (61.76 %).
  • The most frequently suspected clinical diagnosis was fibroma (17.65 %).
  • CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
  • [MeSH-major] Granular Cell Tumor / epidemiology. Mouth Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Child, Preschool. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Female. Fibroma / diagnosis. Humans. Male. Middle Aged. Retrospective Studies. Skin Neoplasms / chemistry. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Staining and Labeling. Young Adult

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  • (PMID = 19445877.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. Wiel J, Luis W, Kempf HG: [The interesting case -- case no. 70]. Laryngorhinootologie; 2005 Mar;84(3):196-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Der interessante Fall Nr. 70.
  • We will report two cases of newborn girls, who could not be breast fed because of a benign tumour in their oral cavity.
  • The size of neoplasm was in one case 3 x 2 cm, in the other one 2 x 1.5 cm.
  • A regular oral feeding was immediately possible.
  • Histological findings showed large tumour cells with abundant granular eosinophilic cytoplasm and a prominent vascularity.
  • All these findings are characteristic of congenital granular cell tumour and its synonym congenital epulis.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Mouth Neoplasms / congenital
  • [MeSH-minor] Age Factors. Breast Feeding. Female. Gingiva / pathology. Humans. Immunohistochemistry. Infant, Newborn. Mouth / pathology. Sex Factors. Treatment Outcome

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  • (PMID = 15770569.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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7. Eguia A, Uribarri A, Gay Escoda C, Crovetto MA, Martínez-Conde R, Aguirre JM: Granular cell tumor: report of 8 intraoral cases. Med Oral Patol Oral Cir Bucal; 2006 Aug;11(5):E425-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor: report of 8 intraoral cases.
  • Granular cell tumor (GCT) is an uncommon neoplasm of controversial origin that can appear in any corporal localization, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most of GCTs are benign.
  • In spite of the amount of research, the etiology of this neoplasm remains unclear and its histogenesis and its possible muscular, connective or neural origin has been broadly debated.
  • In this paper 8 oral cases are presented, corresponding to 5 women and 3 men, with a mean age of 36.1 years old and a mean time of evolution of the lesions of 8.3 months.
  • The main clinicopathologic and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Gingival Neoplasms / pathology. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16878061.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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8. Dilsiz A, Aydin T, Gursan N: Capillary hemangioma as a rare benign tumor of the oral cavity: a case report. Cases J; 2009;2:8622

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Capillary hemangioma as a rare benign tumor of the oral cavity: a case report.
  • INTRODUCTION: Hemangioma is a relatively common benign proliferation of blood vessels that primarily develops during childhood.
  • Early detection and biopsy is necessary to determine the clinical behavior of the tumor and potential dentoalveolar complications.

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  • (PMID = 20181211.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827094
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9. Zehlicke T, Lessle M, Gramer L: [The "ancient schwannoma". A rare tumor of the mouth floor]. HNO; 2006 Apr;54(4):307-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The "ancient schwannoma". A rare tumor of the mouth floor].
  • "Ancient schwannomas" of the mouth floor are rare, benign neoplasms derived from the nerve sheath of peripheral nerves.
  • Ancient schwannomas show histopathological features, such as degenerative changes and atypical nuclei, and may easily be confused with malignant neoplasms.
  • B-scan sonography for the mouth floor and MRT imaging may be helpful in differential diagnosis.
  • Here, we report on a patient with ancient schwannoma of the floor of the mouth.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Hypoglossal Nerve Diseases / diagnosis. Mouth Floor. Mouth Neoplasms / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / analysis. Lymph Nodes / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Ultrasonography

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  • (PMID = 15951994.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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10. Johann AC, Salla JT, Gomez RS, de Aguiar MC, Gontijo B, Mesquita RA: GLUT-1 in oral benign vascular lesions. Oral Dis; 2007 Jan;13(1):51-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] GLUT-1 in oral benign vascular lesions.
  • AIM: To investigate the accuracy of histological diagnosis of oral hemangioma, oral vascular malformation and oral pyogenic granuloma according to immunohistochemical evaluation of the human erythrocyte-type glucose transporter protein (GLUT-1), and to observe the immunoexpression of this protein in oral varix.
  • MATERIALS AND METHODS: Immunohistochemistry for GLUT-1 was performed in 93 histologically diagnosed cases of oral benign vascular lesions: 17 vascular malformations, 19 hemangiomas, nine varix, and 48 pyogenic granulomas.
  • RESULTS: None of the cases of the oral benign vascular lesions evaluated were immunopositive to GLUT-1.
  • The 19 cases histologically diagnosed as oral hemangioma that showed negative staining to GLUT-1 were reclassified as oral pyogenic granuloma or oral vascular malformations.
  • The histological evaluation itself is not enough to obtain the correct diagnosis of oral HEM as none of the sample cases were true hemangioma.
  • All sample cases with initial vascular malformation or pyogenic granulomas classification were negative to GLUT-1, demonstrating the accuracy of histological diagnosis of these lesions itself.
  • Oral varix showed negative staining to GLUT-1 in blood vessels.
  • CONCLUSIONS: GLUT-1 is an useful, effective and important auxiliary marker for the diagnosis of oral benign vascular lesions.
  • CLINICAL RELEVANCE: This study showed that histological diagnosis alone is not sufficient to correct diagnoses of oral hemangioma.
  • Accurate diagnosis of these oral lesions has an important clinical relevance allowing:.
  • [MeSH-major] Glucose Transporter Type 1 / analysis. Mouth Diseases / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers / analysis. Biomarkers, Tumor / analysis. Blood Vessels / abnormalities. Blood Vessels / pathology. Diagnosis, Differential. Granuloma, Pyogenic / diagnosis. Granuloma, Pyogenic / pathology. Hemangioma / diagnosis. Hemangioma / pathology. Humans. Immunohistochemistry. Mouth / blood supply. Varicose Veins / diagnosis. Varicose Veins / pathology

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  • (PMID = 17241430.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1
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11. Hamsch C, Hartschuh W: Microcystic adnexal carcinoma - aggressive infiltrative tumor often with innocent clinical appearance. J Dtsch Dermatol Ges; 2010 Apr;8(4):275-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcystic adnexal carcinoma - aggressive infiltrative tumor often with innocent clinical appearance.
  • The benign histologic appearance, particularly in the upper level of the tumor, can be confused with syringoma or benign follicular neoplasm.
  • We report two patients with microcystic adnexal carcinoma, using them as a basis to discuss, pathogenesis, diagnosis, histology and therapy of the tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Facial Neoplasms / pathology. Facial Neoplasms / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery

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  • (PMID = 19788582.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Gao HW, Ho JY, Lee HS, Yu CP: The presence of Merkel cells and CD10- and CD34-positive stromal cells compared in benign and malignant oral tumors. Oral Dis; 2009 May;15(4):259-64
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The presence of Merkel cells and CD10- and CD34-positive stromal cells compared in benign and malignant oral tumors.
  • BACKGROUND: To describe sequential changes in Merkel cells (MC), and CD10(+) and CD34(+) stromal cells (SC) during the transition from benign to malignant oral lesions and correlate with clinicopathologic parameters.
  • MATERIALS AND METHODS: Changes in cytokeratin 20-positive (CK20(+)) Merkel cells, CD10(+) and CD34(+) SC were immunohistochemically examined in specimens of 28 oral verrucous carcinomas (VC), 32 squamous cell carcinomas (SCC) and 36 benign squamous lesions (BSL).
  • However, the three tumor types had similar staining level and number of CD10(+) SC.
  • CONCLUSION: CD34(+) SC and to a lesser extent MC, but not CD10(+) SC, reveal statistically different density during the transition from benign to malignant oral lesions.
  • The correlations between the CD34(+) SC expression and squamous lesions may be associated with epithelial dysplasia and/or tumor invasion.
  • [MeSH-major] Antigens, CD34 / analysis. Merkel Cells / pathology. Mouth Neoplasms / pathology. Neprilysin / analysis. Stromal Cells / pathology

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  • (PMID = 19220765.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Chromogenic Compounds; 0 / Keratin-20; EC 3.4.24.11 / Neprilysin
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13. López-Jornet P: Granular cell tumor of the tongue. N Y State Dent J; 2008 Aug-Sep;74(5):71-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the tongue.
  • Granular cell tumor is an uncommon benign hamartomatous lesion occurring in almost any part of the body.
  • In this paper, we report the occurrence of an oral granular cell tumor affecting the tongue of a 45-year-old male patient.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Mouth Mucosa / pathology. Treatment Outcome

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  • (PMID = 18982973.001).
  • [ISSN] 0028-7571
  • [Journal-full-title] The New York state dental journal
  • [ISO-abbreviation] N Y State Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Mazza D, Taffon C, Scarpato P, Barchetti F, Agrillo A: Atypical localization and atypical magnetic resonance imaging findings of a paraganglioma at the mouth mucosa. J Craniofac Surg; 2010 Mar;21(2):400-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical localization and atypical magnetic resonance imaging findings of a paraganglioma at the mouth mucosa.
  • The benign nature of the lesion was certainly suggested by the patient's anamnesis, ecotomography, and needle biopsy; nevertheless, before the excision, the surgeon requested magnetic resonance imaging with contrast stain only to better evaluate the relationship between the lesion and the surrounding structures and not to have a precise diagnosis.Under magnetic resonance examination by using T1, T2, and T1 before and after contrast sequences, it showed an aspect different from the conventionally described features for this kind of lesion.
  • Histologic examination described it as having the features of a glomus tumor.
  • [MeSH-major] Cheek / pathology. Magnetic Resonance Imaging. Mouth Neoplasms / diagnosis. Paraganglioma / diagnosis
  • [MeSH-minor] Aged. Biopsy, Needle. Contrast Media. Diagnosis, Differential. Glomus Tumor / diagnosis. Humans. Male. Ultrasonography, Doppler, Color

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  • (PMID = 20186079.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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15. Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE: Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature. J Periodontol; 2007 Aug;78(8):1639-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Nerve sheath myxoma (NSM) is an extremely rare benign neoplasm in the oral cavity.
  • According to the histopathologic and immunohistochemical features, the diagnosis of NSM was established.
  • CONCLUSION: Although NSM is an extremely rare oral tumor, it should be considered in the clinical differential diagnosis of gingival nodules.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myxoma / diagnosis. Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Gingival Hyperplasia / diagnosis. Humans. Incisor / pathology. Mandible / pathology. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 17668985.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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16. El-Sayed I, Huang X, Macheret F, Humstoe JO, Kramer R, El-Sayed M: Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer. Technol Cancer Res Treat; 2007 Oct;6(5):403-12
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  • [Title] Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer.
  • The fluorescence of two fluorophores that are responsible for tissue autofluorescence, NADH and collagen, and of two oral squamous carcinoma cell lines and one immortalized benign epithelial cell line were measured in vitro.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Epithelial Cells / pathology. Gold. Metal Nanoparticles. Molecular Probes. Mouth Neoplasms / diagnosis. Spectrometry, Fluorescence / methods
  • [MeSH-minor] Collagen / analysis. Collagen / metabolism. Contrast Media / pharmacology. Humans. NAD / analysis. NAD / metabolism. Oxidation-Reduction. Pilot Projects. Tumor Cells, Cultured

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  • (PMID = 17877428.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Molecular Probes; 0U46U6E8UK / NAD; 7440-57-5 / Gold; 9007-34-5 / Collagen
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17. Mandal S, Varma K, Khurana N, Mandal AK: Calcifying epithelial odontogenic tumor: report of two cases. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):397-8
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  • [Title] Calcifying epithelial odontogenic tumor: report of two cases.
  • Calcifying epithelial odontogenic tumor (CEOT) is a rare, benign odontogenic tumor.
  • It constitutes 0.4-3% of all odontogenic tumors.
  • Although these lesions are benign, they can be locally aggressive, but malignant transformation and metastasis is rare.
  • [MeSH-major] Calcinosis. Mouth Neoplasms / diagnosis. Mouth Neoplasms / pathology. Odontogenic Tumors / diagnosis. Odontogenic Tumors / pathology. Palate, Hard / pathology

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  • (PMID = 18723969.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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18. Prochasek W, Koszowski R, Steplewska K: [A rare case of neurilemmoma of the floor of the mouth]. Wiad Lek; 2008;61(7-9):236-8
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  • [Title] [A rare case of neurilemmoma of the floor of the mouth].
  • Neurilemmoma is a benign neoplasm of neuroectodermal origin.
  • The authors present a rare case of this lesion localized in the oral cavity.
  • Clinical symptoms, histologic structure of the tumor, methods of treatment and differential diagnosis are described.
  • [MeSH-major] Mouth Floor. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Mouth Mucosa / pathology. Mouth Mucosa / surgery. Treatment Outcome. Young Adult

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  • (PMID = 19172839.001).
  • [ISSN] 0043-5147
  • [Journal-full-title] Wiadomości lekarskie (Warsaw, Poland : 1960)
  • [ISO-abbreviation] Wiad. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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19. Abbas NF, Labib El-Sharkawy S, Abbas EA, Abdel Monem El-Shaer M: Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar;103(3):385-90
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  • [Title] Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma.
  • OBJECTIVES: Mutation of the p53 gene and overexpression of its protein are frequent in human cancer, suggesting that these events play a critical role in the onset or progression of many types of tumors.
  • Angiogenesis also has been demonstrated to be associated with tumor progression, aggressiveness, and metastases.
  • This study aimed to investigate-in normal oral epithelium, hyperplasia, dysplasia, and invasive oral squamous cell carcinoma-the prevalence of p53 protein immunoreactivity and of angiogenesis, and to determine the correlation between them.
  • Seven normal samples of oral mucosa were used as control.
  • RESULTS: This study showed that p53 protein was confined to the basal cell layer in normal oral mucosa and in the hyperplastic group.
  • The percentage of p53-positive cells was evaluated, and statistically significant differences were found between normal oral mucosa and severe dysplasia, between normal mucosa and invasive carcinoma, and between mild and severe dysplasia. p53 expression showed no significant correlation with tumor grading.
  • The number and size of blood vessels increased from normal oral epithelium through dysplastic epithelium to reach a maximum in invasive carcinoma.
  • CONCLUSION: Angiogenesis and p53 protein immunoreactivity increased with progression from normal mucosa to invasive carcinoma, and both factors were directly correlated to each other suggesting that they may play a critical role in oral carcinogenesis.
  • [MeSH-major] Carcinoma, Squamous Cell / chemistry. Mouth Neoplasms / chemistry. Neovascularization, Pathologic. Precancerous Conditions / chemistry. Tumor Suppressor Protein p53 / analysis
  • [MeSH-minor] Analysis of Variance. Biomarkers, Tumor. Cell Transformation, Neoplastic. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Mouth Mucosa / chemistry. Mouth Mucosa / pathology. Mutation. Prognosis. Statistics, Nonparametric. von Willebrand Factor / analysis

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  • (PMID = 17321451.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53; 0 / von Willebrand Factor
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20. Keleş E, Akpolat N, Alpay HC, Tazegül A: [A rare tumor in a newborn: congenital epulis]. Kulak Burun Bogaz Ihtis Derg; 2005;14(3-4):92-5
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  • [Title] [A rare tumor in a newborn: congenital epulis].
  • A seven-day-old female newborn was examined for a mass protruding from the mouth.
  • Histopathologic diagnosis was congenital epulis.
  • Congenital epulis is a benign tumor.
  • [MeSH-major] Gingival Diseases / diagnosis. Gingival Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant, Newborn

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  • (PMID = 16227732.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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21. Hoseini AT, Razavi SM, Khabazian A: Lipoma in oral mucosa: two case reports. Dent Res J (Isfahan); 2010;7(1):41-3

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  • [Title] Lipoma in oral mucosa: two case reports.
  • Lipoma is a common tumor of soft tissue.
  • Its location on the oral mucosa is rare, representing 1% to 5% of benign oral tumors although it is the most mesenchymal tumor of the trunk and proximal por-tions of extremities.
  • Lipoma of the oral cavity may occur in any region.
  • The buccal mucosa, tongue, and floor of the mouth are among the common locations.
  • The overlying epithelium is intact, and superficial blood vessels are usually evident over the tumor.
  • Other benign connective tissue lesions such as granular cell tumor, neurofibroma, traumatic fibroma and salivary gland lesions (mucocele and mixed tumor) might be included in differential diagnosis.
  • We present two cases of oral lipoma in unusual locations: one in junction of soft and hard palate and the other in tongue.

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  • [Cites] J Clin Periodontol. 2001 Feb;28(2):109-12 [11168734.001]
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  • (PMID = 21448446.001).
  • [ISSN] 2008-0255
  • [Journal-full-title] Dental research journal
  • [ISO-abbreviation] Dent Res J (Isfahan)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3065337
  • [Keywords] NOTNLM ; Differential diagnosis / Lipoma / Pathology
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22. Nakano H, Ota Y, Yura Y: Calcifying epithelial odontogenic tumor of the maxilla with ulcerative stomatitis: a case report. Br J Oral Maxillofac Surg; 2009 Apr;47(3):222-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calcifying epithelial odontogenic tumor of the maxilla with ulcerative stomatitis: a case report.
  • Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic tumor, known as Pindborg tumor.
  • We report maxillary CEOT in a patient who complained of spontaneous pain due to extensive ulcer formation of the oral mucosa.
  • [MeSH-major] Gingivitis, Necrotizing Ulcerative / etiology. Maxillary Neoplasms / pathology. Odontogenic Tumors / pathology
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Calcinosis. Female. Humans. Mouth Mucosa / pathology. Mucositis / drug therapy. Mucositis / etiology. Mucositis / pathology

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  • (PMID = 18790551.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal
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23. Xing RD, Chang SM, Li JH, Li H, Han ZX: Serum hyaluronan levels in oral cancer patients. Chin Med J (Engl); 2008 Feb 20;121(4):327-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum hyaluronan levels in oral cancer patients.
  • BACKGROUND: Hyaluronan (HA) is most likely associated with tumor invasion and metastasis.
  • Studies have shown that HA levels are often increased in serum of patients with various malignant tumors.
  • The purpose of this study was to determine the levels of serum hyaluronan in patients with oral cancer and evaluate the value of serum HA in adjuvant diagnosis, staging and monitoring treatment response in these patients.
  • METHODS: Eighty-four hospitalized patients with oral cancer, 65 patients with benign tumors in the oral and maxillofacial region and 67 healthy individuals were included in this investigation.
  • One week after therapy, venous blood was collected once again in 43 patients with oral cancer.
  • RESULTS: The serum HA concentration was significantly higher in oral cancer patients than in patients with benign tumors and in healthy controls (P<0.05).
  • After a complete treatment the HA levels in patients with oral cancer became lower than before treatment, but the difference was not significant (P>0.05).
  • CONCLUSIONS: The results of this study suggest that the determination of HA levels may provide additional information in diagnosis of oral cancer, but its usefulness as an adjunct in clinical staging and in monitoring treatment response was limited.
  • [MeSH-major] Hyaluronic Acid / blood. Mouth Neoplasms / blood
  • [MeSH-minor] Aged. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 18304465.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 9004-61-9 / Hyaluronic Acid
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24. Magro G, Greco P, Alaggio R, Gangemi P, Ninfo V: Polypoid angiomyofibroblastoma-like tumor of the oral cavity: a hitherto unreported soft tissue tumor mimicking embryonal rhabdomyosarcoma. Pathol Res Pract; 2008;204(11):837-43
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  • [Title] Polypoid angiomyofibroblastoma-like tumor of the oral cavity: a hitherto unreported soft tissue tumor mimicking embryonal rhabdomyosarcoma.
  • We report on a previously unrecognized fibro-myofibroblastic tumor in the oral cavity of a 15-year-old girl.
  • Morphologically, the tumor mimicked a rhabdomyosarcoma, botryoid variant.
  • The tumor contained abundant small- to medium-sized, thin-walled blood vessels without hyalinization.
  • The presence of these collagen mats and the expression of desmin, in association with no immunoreactivity to myogenin and MyoD1, were in keeping with the fibro-myofibroblastic nature of the tumor, excluding the diagnosis of embryonal rhabdomyosarcoma.
  • Regarding fibro-myofibroblastic tumors, we believe that the present case falls within the wide spectrum of benign stromal tumors, originally described in the lower female genital tract, but potentially occurring also at extragenital sites.
  • As morphological and immunohistochemical features were reminiscent of, but not identical with, angiomyofibroblastoma, the term "polypoid angiomyofibroblastoma-like tumor" is proposed.
  • Awareness and recognition of this tumor is crucial to avoid a diagnosis of malignancy.
  • [MeSH-major] Mouth Neoplasms / pathology. Rhabdomyosarcoma, Embryonal / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18656317.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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25. Xue JL, Fan MW, Wang SZ, Chen XM, Li Y: [A clinicopathological study of 14 cases of oral granular cell tumor]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jul;40(4):302-5
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  • [Title] [A clinicopathological study of 14 cases of oral granular cell tumor].
  • OBJECTIVE: To describe clinical and histological features of oral granular cell tumor (OGCT)and discuss their proliferative activity.
  • METHODS: Clinical and microscopic features were assessed in 14 cases of OGCT collected from the department of oral pathology, college of stomatology of Wuhan University between 1970 and 2003.
  • Immunohistochemical analysis disclosed that 100% of granular cells demonstrated moderated/strong staining for S-100 protein, neuron specific enolase (NSE).
  • Seven patients with benign and two patients with atypical granular cell tumor had no recurrence and metastases.
  • One patient with atypical granular cell tumor had local recurrence after 9 years and died of the disease 10 months later.
  • Most OGCTs are benign but few have malignant potential and periodic follow-up is mandatory to detect malignant transformation.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology

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  • (PMID = 16191373.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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26. Vered M, Carpenter WM, Buchner A: Granular cell tumor of the oral cavity: updated immunohistochemical profile. J Oral Pathol Med; 2009 Jan;38(1):150-9
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  • [Title] Granular cell tumor of the oral cavity: updated immunohistochemical profile.
  • BACKGROUND: Granular cell tumor (GCT) is a benign lesion that occurs at different body sites with preponderance to the oral cavity.
  • METHODS: The patients' demographic data and the cytological and architectural features of the lesions were analyzed in a large series of oral GCTs (n = 68).
  • RESULTS: The tongue was the most common location of oral GCTs (81%).
  • Furthermore, GCTs could be regarded as lesions that reflect a local metabolic or reactive change rather than a true neoplasm.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Calbindin 2. Cell Nucleus / pathology. Cell Shape. Child. Female. Humans. Immunohistochemistry. Inhibins / analysis. Macrophages / pathology. Male. Membrane Glycoproteins. Middle Aged. Nerve Tissue Proteins / analysis. Receptors, Nerve Growth Factor / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Tongue Neoplasms / pathology. Ubiquitin Thiolesterase / analysis. Vimentin / analysis. Young Adult. gp100 Melanoma Antigen

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  • (PMID = 19192059.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / CD68 antigen, human; 0 / Calbindin 2; 0 / Membrane Glycoproteins; 0 / NGFR protein, human; 0 / Nerve Tissue Proteins; 0 / PMEL protein, human; 0 / Receptors, Nerve Growth Factor; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; 0 / gp100 Melanoma Antigen; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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27. Weissferdt A, Langman G: An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma. Pathol Res Pract; 2010 Jul 15;206(7):480-3
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  • [Title] An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.
  • Malignant mixed tumors of the salivary glands, encompassing carcinoma ex pleomorphic adenoma (ca ex PA), carcinosarcoma and metastasizing pleomorphic adenoma (mPA), are rare neoplasms.
  • When the malignant component does not breach the capsule of the parent PA, the lesion is termed intracapsular ca ex PA, a neoplasm which is thought to have no metastatic potential.
  • Metastatic deposits of ca ex PA are composed exclusively of malignant elements or mixed benign and malignant components.
  • The metastatic deposits resembled benign PA with no histological evidence of malignancy.
  • This pattern of spread is described with mPA, an entity that caused controversy in the past regarding its exact classification as a benign or malignant tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lung Neoplasms / secondary. Mouth Mucosa / pathology. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19665316.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Scariot R, Giovanini AF, Torres-Pereira CC, Piazzetta CM, Costa DJ, Rebellato NL, Müller PR: Massive growth of an intraoral lipoma. J Contemp Dent Pract; 2008;9(7):115-21
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  • BACKGROUND: Lipoma, a benign tumor of adipose tissue, is rarely seen in the oral cavity.
  • When it does occur it is usually found in the cheek or tongue, followed by the lip, gingival, and floor of the mouth.
  • A clinical diagnosis of lipoma was established, and the treatment consisted of complete excision of the mass under local anesthesia.
  • SUMMARY: Although some larger oral masses are better managed surgically at hospital facilities, the present case was treated with local anesthesia with no complications.
  • CLINICAL SIGNIFICANCE: This case report emphasizes the slow growth and benign characteristics of oral lipomas.
  • [MeSH-major] Cheek / pathology. Lipoma / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Mouth Mucosa / pathology

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  • (PMID = 18997924.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Lo Muzio L, Mascolo M, Capodiferro S, Favia G, Maiorano E: Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis. J Oral Pathol Med; 2007 Oct;36(9):538-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis.
  • BACKGROUND: Solitary fibrous tumor (SFT) is an uncommon but well-characterized soft tissue tumor that was first described as a pleural lesion and now is considered ubiquitous, having been detected at many extra-pleural sites (abdominal cavity, orbit, upper respiratory tract, and oral cavity).
  • Histologically, SFT may show wide morphological variability of both its cellular and stromal components, which may lead to incorrect diagnosis especially when dealing with small incisional biopsies.
  • MATERIALS: We report on the clinical, morphological and immunohistochemical features of eight SFT occurring in the oral cavity.
  • RESULTS: Microscopically all eight tumors showed widely variable morphological features in terms of cellular density and stromal architecture, thus simulating benign fibrous histiocytoma, schwannoma, hemangiopericytoma or low-grade sarcoma in distinct areas of the same lesion.
  • Among these eight cases, five had been diagnosed as SFT, two as benign fibrous histiocytoma and one as low-grade sarcoma.
  • [MeSH-major] Mouth Neoplasms / diagnosis. Neoplasms, Fibrous Tissue / diagnosis
  • [MeSH-minor] Adult. Aged. Cytodiagnosis / methods. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged

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  • (PMID = 17850437.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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30. Bell DM, Dekmezian RH, Husain SA, Luna MA: Oral calcifying fibrous pseudotumor: case analysis and review. Head Neck Pathol; 2008 Dec;2(4):343-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral calcifying fibrous pseudotumor: case analysis and review.
  • Occurring most often in children and young adults, CFTs are clinically benign lesions that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, as well as in serosal and visceral locations.
  • In this article, we describe a case of CFT in a 29-year-old woman with a 7-cm mass on the right upper gingiva and hard palate, discuss the differential diagnosis with other oral spindle cell lesions, such as, desmoid fibromatosis, nodular fasciitis, inflammatory myofibroblastic tumors, solitary fibrous tumor and also review the recent literature on this rare benign entity.
  • [MeSH-major] Calcinosis / pathology. Granuloma, Plasma Cell / diagnosis. Mouth Diseases / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fasciitis / diagnosis. Female. Fibromatosis, Aggressive / diagnosis. Fibrosis. Gingiva / pathology. Humans. Palate, Hard / pathology. Solitary Fibrous Tumors / diagnosis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20614307.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807574
  • [Keywords] NOTNLM ; Calcifying / Fibrous / Oral / Pseudotumor / Tumor
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31. Lee LT, Kwan PC, Wong YK: Novel application of artificial dermis plus autologous vital epithelial cells: improved wound epithelialization. J Chin Med Assoc; 2010 Feb;73(2):108-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to evaluate artificial dermis with the simultaneous addition of autologous epithelial cells for oral lesion defect reconstruction.
  • Surgical wounds reconstructed with artificial dermis plus scraped epithelial cells were evaluated in 5 patients with oral benign lesions or squamous cell carcinoma.
  • Clinical observation showed that the oral mucosal texture was smoother in artificial dermis with added epithelial cells at 4 weeks postoperation compared with artificial dermis alone.
  • We showed that healthy granulation tissue and neoepithelial formation in artificial dermis with epithelial cells was beneficial for the repair of oral defects.
  • Scraping oral epithelial cells and applying them to artificial dermis assisted in the early preparation of composite grafts and minimized requirement for donor sites.
  • This technique may improve the treatment of patients with oral benign tumors and early-stage squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Dermis / transplantation. Epithelial Cells / transplantation. Mouth Neoplasms / surgery. Skin, Artificial. Wound Healing
  • [MeSH-minor] Humans. Mouth Mucosa / surgery. Transplantation, Autologous

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20171593.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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32. Ferreti Bonan PR, Martelli H Jr, Nogueira Dos Santos LA, Comini Mol V, Paes De Almeida O: Multinodular neurilemmoma of the tongue: a case report with differential immunohistochemical profile. Minerva Stomatol; 2008 Jan-Feb;57(1-2):71-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurilemmoma is a distinctive, encapsulated, benign tumor, derived from Schwann cells.
  • It is the most common neurogenic tumor, eventually occurring in the mouth, particularly the tongue.
  • The presumptive diagnosis was of a benign mesenchymal neoplasm and an excisional biopsy was performed.
  • Histopathologic evaluation revealed an encapsulated benign tissue, formed by spindle cells forming irregular Antoni A and Antoni B patterns, not easily recognizable.
  • [MeSH-major] Neurilemmoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 18427374.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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33. Brooks JK, Scheper MA, Schwartz KG, Nikitakis NG: Oral lipoma: report of three cases. Gen Dent; 2008 Mar-Apr;56(2):172-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral lipoma: report of three cases.
  • Oral lipomas are benign lesions that are seen infrequently in the dental practice.
  • Two of the tumors were located on the buccal mucosa, while the other mass arose on the mandibular buccal/labial vestibule, was considerably larger in size, produced extraoral swelling, and necessitated a preoperative MRI due to close approximation to the mental nerve.
  • The tumor adipocytes were similar to normal adult fat cells and contained a small, uniformly eccentric nucleus with a single, clear cytoplasmic vacuole.
  • [MeSH-major] Lipoma / surgery. Mouth Mucosa / pathology. Mouth Neoplasms / surgery

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  • (PMID = 18348376.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Gerstner AO, Thiele A, Tárnok A, Tannapfel A, Weber A, Bootz F: Prediction of upper aerodigestive tract cancer by slide-based cytometry. Cytometry A; 2006 Jul;69(7):582-7
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  • METHODS: Laser scanning cytometry (LSC) was used for multiparametric analysis of cells stained for cytokeratin and DNA to determine the DNA-index (DI) of the tumor cells.
  • In the remaining 99 specimens, 1 benign lesion was misclassified as malignant, while 61 of the 75 malignant lesions were correctly identified.
  • This corresponds to predictive values of 98.4% and 62.2% for the detection of malignant and benign samples by LSC.
  • CONCLUSION: This pilot study demonstrates the validity of LSC screening for the identification of tumor malignancy in the upper aerodigestive tract from swab collected cytological material.
  • [MeSH-major] Laser Scanning Cytometry / methods. Mouth Neoplasms / diagnosis. Respiratory Tract Neoplasms / diagnosis

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  • [Copyright] Copyright 2006 International Society for Analytical Cytology.
  • (PMID = 16807892.001).
  • [ISSN] 1552-4922
  • [Journal-full-title] Cytometry. Part A : the journal of the International Society for Analytical Cytology
  • [ISO-abbreviation] Cytometry A
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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35. Dennis MM, Ehrhart N, Duncan CG, Barnes AB, Ehrhart EJ: Frequency of and risk factors associated with lingual lesions in dogs: 1,196 cases (1995-2004). J Am Vet Med Assoc; 2006 May 15;228(10):1533-7
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  • RESULTS: Neoplasia comprised 54% of lingual lesions.
  • Malignant tumors accounted for 64% of lingual neoplasms and included melanoma, squamous cell carcinoma, hemangiosarcoma, and fibrosarcoma.
  • Benign neoplasms included squamous papilloma, plasma cell tumor, and granular cell tumor.
  • Small-breed dogs, especially Cocker Spaniels, were at increased risk for plasma cell tumors.
  • Whereas large-breed dogs were more likely to have lingual neoplasia, small-breed dogs were more likely to have glossitis.
  • Veterinarians should be aware of the commonly reported lingual lesions in dogs so that prompt diagnosis and appropriate management can be initiated.
  • [MeSH-major] Dog Diseases / epidemiology. Mouth Diseases / veterinary
  • [MeSH-minor] Age Factors. Animals. Dogs. Female. Glossitis / epidemiology. Glossitis / pathology. Glossitis / veterinary. Male. Mouth Neoplasms / epidemiology. Mouth Neoplasms / pathology. Mouth Neoplasms / veterinary. Prevalence. Retrospective Studies. Risk Factors. Sex Factors. Species Specificity

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  • (PMID = 16677121.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Haikal F, Maceira J, Dias E, Ramos-E-Silva M: Histogenesis of Abrikossoff tumour of the oral cavity. Int J Dent Hyg; 2010 Feb;8(1):53-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histogenesis of Abrikossoff tumour of the oral cavity.
  • BACKGROUND: Abrikossoff or granular cell tumour (GCT) is a relatively rare neoplasia, benign in most of the cases.
  • It may occur in any part of the human body, but it has an oral location in 70% of the cases.
  • OBJECTIVE: Contribute to the clarification of histogenesis of oral Abrikossoff tumour studying immunohistochemical marking of 11 oral Brazilian cases.
  • MATERIALS AND METHODS: Samples of tissues from the oral mucosa, tongue and lips placed in paraffin blocks, from eleven patients with a histopathological diagnosis of benign GCT were studied.
  • New methods and more specific immunohistochemical markers are needed to elucidate the origin of the Abrikossoff tumour.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Cytoplasm / pathology. Female. Humans. Hyperplasia. Immunohistochemistry. Lip Neoplasms / pathology. Male. Middle Aged. Mouth Mucosa / pathology. Neuroendocrine Cells / pathology. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis. Schwann Cells / pathology. Tongue Neoplasms / pathology. Ubiquitin Thiolesterase / analysis. Vimentin / analysis. Young Adult

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  • (PMID = 20096083.001).
  • [ISSN] 1601-5037
  • [Journal-full-title] International journal of dental hygiene
  • [ISO-abbreviation] Int J Dent Hyg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase; EC 4.2.1.11 / Phosphopyruvate Hydratase
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37. Betka J, Chovanec M, Klozar J, Taudy M, Plzák J, Kodetová D, Lisý J: Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors. Eur Arch Otorhinolaryngol; 2010 May;267(5):765-72
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  • [Title] Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors.
  • The goal of parapharyngeal space (PPS) tumor surgery is to obtain adequate visualization to ensure complete removal with preservation of the surrounding nerves and vessels.
  • Transoral approach is the most controversial one due to cited limited exposure, risk of tumor spillage, and possibility of neurovascular injury.
  • We performed retrospective analysis of 26 consecutive patients who had undergone transoral or combined transoral-transcervical resection of PPS tumors from January 1997 to December 2007.
  • Both approaches were safely employed to remove selected PPS tumors.
  • Majority of treated tumors were pleomorphic adenomas (14 minor salivary gland and 7 deep lobe parotid gland tumors).
  • Two cases of malignant salivary gland tumors, 4 nerve sheath tumors and 1 lymphangioma were also excised.
  • Mean tumor size was 6.1 cm (range 2-11 cm).
  • Patients with malignant tumors had postoperative radiotherapy.
  • One of the near-totally resected tumors needed revision surgery.
  • Transoral approach provides access to selected cases of PPS tumors based on preoperative imaging methods and fine-needle aspiration cytology.
  • Risk of non-radical resection is acceptable.
  • It can be combined with external approach to achieve safe resection of some benign tumors which would need transmandibular approach.
  • [MeSH-major] Otorhinolaryngologic Surgical Procedures / methods. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Male. Mouth. Neck. Neoplasm Staging. Nerve Sheath Neoplasms / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 19714351.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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38. Ruschel HC, Beilke LP, Beilke RP, Kramer PF: Congential epulis of newborn: report of a spontaneous regression case. J Clin Pediatr Dent; 2008;33(2):167-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Congenital epulis of newborn is a rare benign tumor that is also known as a congenital granular cell tumor.
  • [MeSH-major] Alveolar Process / surgery. Gingival Neoplasms / surgery. Maxillary Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Infant, Newborn. Mouth Mucosa / pathology. Mouth Mucosa / surgery. Treatment Outcome

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  • (PMID = 19358386.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Brooks MD, Bennett RD, Strehler EE, Sebo TJ, Eckert SE, Carr AB: Human calmodulin-like protein (CLP) expression in oral squamous mucosa and in malignant transformation. J Prosthodont; 2009 Jan;18(1):11-6
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  • [Title] Human calmodulin-like protein (CLP) expression in oral squamous mucosa and in malignant transformation.
  • PURPOSE: The purpose of this study was to test whether calmodulin-like protein (CLP) is expressed in normal human oral mucosal cells and if downregulation of CLP occurs in malignant transformation.
  • MATERIALS AND METHODS: Oral mucosal tissue was taken from three individuals in a double-blind manner.
  • Three oral mucosal tissue samples with biopsy-confirmed squamous cell carcinoma were obtained.
  • Staining patterns and intensity were noted in normal oral mucosa, comparing them to the normal breast epithelium sample.
  • Staining patterns and intensity were then observed in squamous tumor cells, comparing them to the patterns of benign squamous mucosa.
  • RESULTS: CLP coding sequences were positively identified from the normal oral mucosal tissue samples by reverse transcription and polymerase chain reaction (RT-PCR) with 100% identity to the published CLP sequence (accession #M58026).
  • In the three oral mucosa tissue samples with known squamous cell carcinoma, expression of CLP was readily detected in areas of normal oral mucosa, while a notable downregulation of CLP expression occurred in areas of malignant transformation.
  • The staining intensity was equivalent to the staining seen in the benign breast epithelium used as a control.
  • There was a sharp contrast in staining quality and clarity between benign and malignant tissue.
  • CONCLUSIONS: The RNA for human CLP is found in normal oral mucosa.
  • CLP expression is seen in normal oral mucosa with a downregulation of CLP expression in malignant transformation.
  • [MeSH-major] Calmodulin / biosynthesis. Carcinoma, Squamous Cell / metabolism. Cell Transformation, Neoplastic / metabolism. Mouth Mucosa / metabolism. Mouth Neoplasms / metabolism

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  • (PMID = 19166543.001).
  • [ISSN] 1532-849X
  • [Journal-full-title] Journal of prosthodontics : official journal of the American College of Prosthodontists
  • [ISO-abbreviation] J Prosthodont
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CALML3 protein, human; 0 / Calmodulin
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40. von Euler H, Sadeghi A, Carlsson B, Rivera P, Loskog A, Segall T, Korsgren O, Tötterman TH: Efficient adenovector CD40 ligand immunotherapy of canine malignant melanoma. J Immunother; 2008 May;31(4):377-84
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  • Cutaneous canine melanomas are usually benign in contrast to human malignant melanoma.
  • However, the canine oropharyngeal, uveal, and mucocutaneous neoplasms are aggressive and have metastatic potential.
  • Case no. 1 was an advanced stage III oral melanoma that was cured from malignant melanoma with 2 intratumor AdCD40L injections before cytoreductive surgery.
  • After treatment, the tumor tissue was infiltrated with T lymphocytes and B lymphocytes suggesting immune activation.
  • One hundred and twenty days after start of gene therapy and 60 days after the last injection, the tumor had regressed dramatically, and the dog had a minimal tumor mass and no signs of progression or metastasis.
  • [MeSH-major] CD40 Ligand / immunology. CD40 Ligand / therapeutic use. Conjunctival Neoplasms / veterinary. Dog Diseases / therapy. Immunotherapy, Active. Melanoma / veterinary. Mouth Neoplasms / veterinary

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  • (PMID = 18391758.001).
  • [ISSN] 1524-9557
  • [Journal-full-title] Journal of immunotherapy (Hagerstown, Md. : 1997)
  • [ISO-abbreviation] J. Immunother.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147205-72-9 / CD40 Ligand; 82115-62-6 / Interferon-gamma
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41. Angiero F, Benedicenti S, Romanos GE, Crippa R: Treatment of hemangioma of the head and neck with diode laser and forced dehydration with induced photocoagulation. Photomed Laser Surg; 2008 Apr;26(2):113-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The aim of this study was to investigate the efficacy of treating oral hemangiomas using forced dehydration with induced photocoagulation (FDIP) via diode laser.
  • RESULTS: In 136 patients with hemangiomas treated with FDIP, 134 cases (98.53%) showed complete remission, one case (0.735%) did not show complete remission, and one case (0.735%) displayed tumor growth.
  • CONCLUSIONS: Our findings suggest that FDIP is a useful and effective treatment for benign oral vascular lesions.
  • FDIP treatment of these oral lesions is clinically significant because it provides effective management, avoids recurrence, and shortens healing time.
  • [MeSH-major] Hemangioma / surgery. Laser Coagulation. Lasers, Semiconductor. Mouth Neoplasms / surgery

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  • (PMID = 18341421.001).
  • [ISSN] 1549-5418
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Ducic Y, Oxford L, Pontius AT: Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg; 2006 Mar;134(3):466-70
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  • OBJECTIVES: To present our early experience with the transoral approach to the superomedial parapharyngeal space (PPS) and describe our technique for removal of these neoplasms.
  • METHODS: Eight patients with various neoplasms of the superomedial PPS were retrospectively reviewed for type of neoplasm, size, success with the transoral approach, need for conversion to another approach, length of hospitalization, and complications.
  • RESULTS: The transoral approach described herein safely allowed for en bloc resection of benign neoplasms with intraoperative control and exposure of the internal carotid artery.
  • Mean tumor size was 3.3 cm (range, 1.5 to 7 cm).
  • This technique is indicated for neoplasms with benign appearance on preoperative imaging or fine needle aspiration.
  • [MeSH-major] Mouth / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carotid Artery, Internal / pathology. Child. Female. Follow-Up Studies. Humans. Intraoperative Care. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications. Retrospective Studies. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 16500446.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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43. Bielecki I, Mniszek J, Zielińska-Pajak E, Pajak J, Kluczewska E, Zygan L: [Cemento-ossifying fibroma--case report and review of the literature]. Otolaryngol Pol; 2005;59(1):109-14
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  • Authors report two cases of benign, osteogenic neoplasms of the maxilla in children which defined as cemento-ossifying fibroma and juvenile cemento-ossifying fibroma.
  • Difficulty in diagnosis of the tumor is indicated.
  • The importance of clinical data as well as radiology and histopathology examination for a proper diagnosis is indicated.
  • [MeSH-major] Cementoma. Fibroma, Ossifying. Maxillary Neoplasms. Nose Neoplasms
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Male. Mouth Mucosa / pathology. Time Factors. Treatment Outcome

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  • (PMID = 15915929.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 13
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44. Tonni G, De Felice C, Centini G, Ginanneschi C: Cervical and oral teratoma in the fetus: a systematic review of etiology, pathology, diagnosis, treatment and prognosis. Arch Gynecol Obstet; 2010 Oct;282(4):355-61
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  • [Title] Cervical and oral teratoma in the fetus: a systematic review of etiology, pathology, diagnosis, treatment and prognosis.
  • INTRODUCTION: The aim of the study was to produce a systematic review about etiology, pathology, diagnosis, prognosis and clinical management regarding oral and cervical teratomas.
  • MATERIALS AND METHODS: A systematic review of Pubmed/Medline using the following keywords was made: epignathus, cervical teratoma, fetus, oral teratoma, prenatal diagnosis, prognosis, treatment, ultrasound.
  • (1) teratomas are rare, usually benign congenital tumors which recognized multifactorial etiology;.
  • (2) prenatal ultrasound diagnosis can be made early in pregnancy (15-16 weeks);.
  • (3) 3D ultrasound and MRI may enhance the accuracy of the antenatal diagnosis (location, extension and intracranial spread) and may aid in the selection of patients requiring treatment;.
  • (5) delivery should involve elective Cesarean section with ex utero intrapartum treatment procedure or resection of the tumor mass, which may be performed on placental support operation on placental support procedure to increase the chances of postnatal survival.
  • [MeSH-major] Fetus / surgery. Head and Neck Neoplasms. Mouth Neoplasms. Teratoma

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  • (PMID = 20473617.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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45. Esquenazi D, Bussoloti Filho I, Carvalho Mda G, Barros FS: The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR. Braz J Otorhinolaryngol; 2010 Jan-Feb;76(1):78-84

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  • [Title] The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR.
  • The human papillomavirus (HPV) is a DNA virus, which belongs to papillomaviridae family, being of low and high risk, which infect the skin and mucous membranes and can induce benign and malign tumor formation.
  • In the oral mucosa they have been associated with oral papilloma, focal epithelial hyperplasia, leucoplakia and oral neoplasia.
  • AIM: to study the frequency of HPV finding in oral mucosa of normal people.
  • One hundred volunteers, young adults, healthy, aged between 20 and 31 years, university students with no history, no complains, without oral or oropharyngeal lesions.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Mouth Mucosa / virology

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  • (PMID = 20339693.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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46. Diniz MG, Borges ER, Guimarães AL, Moreira PR, Brito JA, Gomez MV, De Marco L, Gomez RS: PTCH1 isoforms in odontogenic keratocysts. Oral Oncol; 2009 Mar;45(3):291-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Odontogenic keratocyst (OKC) is an aggressive benign odontogenic neoplasm associated with PTCH1 alteration.
  • The aim of the present study was to investigate the expression of PTCH1 first exons in OKC tumors to shed light on scenery whereby PTCH1 coordinates OKC tumorigenesis.
  • In addition, the pattern of exon 1 expression observed in oral mucosa adjacent to the OKC was similar to the OKC tumor.
  • In conclusion, this report showed overactivity of Hedgehog (HH) pathway in OKC lesion and at adjacent oral mucosa.
  • [MeSH-minor] Adolescent. Adult. Basal Cell Nevus Syndrome / genetics. Basal Cell Nevus Syndrome / metabolism. Exons / genetics. Female. Humans. Male. Middle Aged. Mouth Mucosa / metabolism. Protein Isoforms / genetics. Protein Isoforms / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Young Adult

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  • (PMID = 18674957.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Receptors, Cell Surface; 0 / patched receptors
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47. Maamouri F, Bellil K, Bellil S, Chelly I, Mekni A, Kchir N, Haouet S, Zitouna M: Canalicular adenoma of buccal mucosa. Pathologica; 2007 Jun;99(3):69-70
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  • Canalicular adenoma is a benign tumor which comprises 1% of salivary gland neoplasms and 4% of minor salivary gland tumors.
  • The next most common location is the buccal mucosa (9.5% of tumors).
  • The treatment was surgery and histological findings were consistent with the diagnosis of canalicular adenoma.
  • [MeSH-major] Adenoma / pathology. Mouth Mucosa. Salivary Gland Neoplasms / pathology

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  • (PMID = 17987725.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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48. Whitt JC, Dunlap CL, Martin KF: Oral Hodgkin lymphoma: a wolf in wolf's clothing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):e45-51
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  • [Title] Oral Hodgkin lymphoma: a wolf in wolf's clothing.
  • The English language literature contains only 7 reports of primary Hodgkin lymphoma arising in the oral mucosa in the absence of nodal disease.
  • An incisional biopsy revealed a diffuse, mixed cellular infiltrate, consisting of benign lymphocytes, plasma cells, histiocytes, and foci rich in eosinophils.
  • Within this background was a scattering of large, atypical cells, including Reed-Sternberg forms that exhibited immunoreactivity for CD30 and CD20 and nonreactivity for CD15 and CD45RO, supporting a diagnosis of classical Hodgkin lymphoma.
  • The primary tumor and submandibular and upper neck lymph nodes were treated with a 6-MV photon beam to a total dose of 4000 cGy.
  • [MeSH-major] Hodgkin Disease / pathology. Mouth Mucosa / pathology. Palatal Neoplasms / pathology. Palate / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Herpesvirus 4, Human / isolation & purification. Humans. Treatment Outcome

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  • (PMID = 17964472.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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49. Driemel O, Berndt A, Hartmann A, Mueller-Richter UD, Bauer R, Reichert TE, Kosmehl H: [Clinical and immunohistochemical findings of intra- and extraoral angiosarcomas]. Mund Kiefer Gesichtschir; 2006 Jul;10(4):239-47
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  • PURPOSE: A clinico-pathologic study of typical symptoms of intra- and extraoral angiosarcomas and clinical course under therapy is presented as well as an analysis of the immunohistochemical differential diagnosis of the tumour specific formed spaces.
  • RESULTS: While the benign appearance of the lesions resulted primarily in wrong diagnoses the histopathologic examination of the biopsies revealed the characteristic pattern of angiosarcomas.
  • Wide surgical excision, radiotherapy and/or antiangiogenic chemotherapy could not prevent tumour progression and death within two and a half years after primary diagnosis.
  • The tumour associated structural defect of vascular lamina with partial loss of pericytes/vascular smooth muscle cells was identified immunohistochemically by alpha-smooth-muscle-actin and for the first time by tenascin-C.
  • ) The variable presentation and the benign appearance of oral and perioral angiosarcomas may often delay diagnosis.
  • Oral and perioral angiosarcomas show poor prognosis despite of multimodal therapy. (2.
  • [MeSH-major] Alveolar Process. Biomarkers, Tumor / analysis. Cheek. Hemangiosarcoma / pathology. Mandibular Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 16788797.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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50. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • [Title] Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases.
  • Lesions involving the oral and maxillofacial region (OMFR) and intraosseous examples are rare.
  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • Histologically, the tumors were well delineated and multinodular, separated by fibrous septae.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Three tumors were graded as 2/3 and two 1/3.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-major] Facial Bones / pathology. Fibrosarcoma / pathology. Maxilla / pathology. Mouth Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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51. Abbo O, Breibach F, Vaysse F, Kessler S, Guitard J, Galinier P: [Antenatal diagnosis of a congenital granular cell tumor]. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):91-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Antenatal diagnosis of a congenital granular cell tumor].
  • [Transliterated title] Tumeur granuleuse gingivale congénitale de découverte anténatale.
  • INTRODUCTION: Neuman's tumors also called congenital epulis or congenital gingival granulomatous tumors are rare and benign oral cavity tumors.
  • A maxillary tumor in the fetus was revealed by the third trimester US.
  • A fetal MRI was prescribed, after discussion with the antenatal diagnostic center, to determine the localization, size, and nature of the tumor.
  • It revealed a 3 cm long tumor with cystic like areas not communicating with the encephalus.
  • Histological analysis confirmed the diagnosis.
  • DISCUSSION: A prenatal diagnosis of congenital gingival granulomatous tumor is rare.
  • Nevertheless, prenatal diagnosis allows for a better postnatal management.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Ultrasonography, Prenatal

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  • (PMID = 20074764.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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52. Patterson MM, Rogers AB, Mansfield KG, Schrenzel MD: Oral papillomas and papilliform lesions in rhesus macaques (Macaca mulatta). Comp Med; 2005 Feb;55(1):75-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral papillomas and papilliform lesions in rhesus macaques (Macaca mulatta).
  • Oral papillomas in two male rhesus macaques that were diagnosed morphologically as filiform and squamous types are described.
  • Two additional macaques had oral papilliform lesions consistent histologically with papillary hyperplasia.
  • Immunohistochemistry, along with electron microscopy and PCR assays, failed to demonstrate evidence of papillomavirus in any of the tumors; however, such results are often lacking when suspect oral lesions in humans and other species are assessed.
  • Benign tumors of the oral epithelium in macaques have not been reported previously; they appear to be rare and of variable clinical significance.
  • [MeSH-major] Macaca mulatta. Monkey Diseases / pathology. Mouth Neoplasms / pathology. Mouth Neoplasms / veterinary. Papilloma / veterinary

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  • (PMID = 15766213.001).
  • [ISSN] 1532-0820
  • [Journal-full-title] Comparative medicine
  • [ISO-abbreviation] Comp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Bozkaya S, Uğar D, Karaca I, Ceylan A, Uslu S, Bariş E, Tokman B: The treatment of lymphangioma in the buccal mucosa by radiofrequency ablation: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Nov;102(5):e28-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lymphangioma is a benign, hamartomatous tumor of the lymphatic system.
  • It is usually found in the head and neck region and is widely regarded as a developmental lesion rather than a true neoplasia.
  • When lymphangioma occurs in the mouth, the anterior two thirds of the tongue is the most commonly affected region.
  • [MeSH-major] Catheter Ablation / methods. Lymphangioma / surgery. Mouth Mucosa / surgery. Mouth Neoplasms / surgery

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  • (PMID = 17052620.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. López-Carriches C, Baca-Pérez-Bryan R, Montalvo-Montero S: Schwannoma located in the palate: clinical case and literature review. Med Oral Patol Oral Cir Bucal; 2009 Sep;14(9):e465-8
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  • Schwannoma is a benign tumor that originates from the presence of Schwann cells of the peripheral nerves.
  • The preoperative diagnosis is often difficult, and although computed tomography and magnetic resonance imaging are very helpful, in the majority of cases, the diagnosis can only be made during surgery and by histological study.
  • It is important to highlight that the Schwannoma is usually found in the head and neck, and rarely in the oral cavity.
  • Other locations in the oral cavity include: the floor of the mouth, palate, gingiva, vestibular mucosa, lips and mental nerve area, listed from most common to least common.
  • [MeSH-major] Neurilemmoma. Palatal Neoplasms

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  • (PMID = 19415055.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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55. Levi PA Jr, Kim DM, Harsfield SL, Jacobson ER: Squamous cell carcinoma presenting as an endodontic-periodontic lesion. J Periodontol; 2005 Oct;76(10):1798-804
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Regardless of advances in diagnosis and treatment during the past 40 years, the overall 5-year survival rates for oral and oropharyngeal squamous cancers have only slightly improved and remain around 50%.
  • Thus, the early diagnosis and treatment of carcinoma by health care providers are essential in achieving a good prognosis.
  • We report a case of invasive squamous cell carcinoma that presented as a benign endodontic-periodontic lesion with a 7-mm periodontal pocket on tooth #15 in a 40-year-old, non-smoking woman.
  • METHODS: Our patient was seen for a comprehensive periodontal examination including a periodontal charting, occlusal analysis, study casts, electronic pulp test for tooth #15, and complete mouth periapical radiographs.
  • The patient remained free of tumor for 5 years after the initial presentation.
  • CONCLUSIONS: Patient education and periodic oral cancer examinations by dental professionals are necessary to reduce diagnostic delay and improve prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Maxillary Neoplasms / pathology. Periodontal Cyst / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Maxillary Sinus Neoplasms / pathology. Neoplasm Invasiveness / pathology

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  • (PMID = 16253104.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Merchant NB, Parikh AA, Kooby DA: Should all distal pancreatectomies be performed laparoscopically? Adv Surg; 2009;43:283-300
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  • There are both enough experience and data (though retrospective) to confirm that LDP with or without spleen preservation appears to be a safe treatment for benign or noninvasive lesions of the pancreas.
  • Based on the fact that LDP can be performed with similar or shorter operative times, blood loss, complication rates, and length of hospital stay than ODP, it can be recommended as the treatment of choice for benign and noninvasive lesions in experienced hands when clinically indicated.
  • It is very difficult to make clear recommendations with regard to laparoscopic resection of malignant pancreatic tumors due to the lack of conclusive data.
  • Can we enucleate a small tumor off the pancreatic body by passing an endoscope through the gastric (or colonic) wall, and bring the specimen out via the mouth or anus?

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  • (PMID = 19845186.001).
  • [ISSN] 0065-3411
  • [Journal-full-title] Advances in surgery
  • [ISO-abbreviation] Adv Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 95
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57. González Sánchez MA, Colorado Bonnin M, Berini Aytés L, Gay Escoda C: Leiomyoma of the hard palate: a case report. Med Oral Patol Oral Cir Bucal; 2007 May;12(3):E221-4
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  • Leiomyoma is a benign smooth muscle tumor that is very rarely located in the oral cavity.
  • It is accepted that the smooth muscle giving rise to this tumor corresponds to the tunica media of the arteries.
  • The tumor can develop at any age, with no clear gender predilection, and typically manifests as a slow-growing, asymptomatic lesion.
  • The diagnosis is based on the histopathological study, with the use of specific staining techniques, including immunohistochemical markers.
  • We present the case of a 57-year-old male with a tumor located for the previous four months in the region of the hard palate, adjacent to the left upper premolars.
  • After surgical resection with safety margins, hematoxylin-eosin staining and immunohistochemical study confirmed the diagnosis of leiomyoma.
  • [MeSH-major] Leiomyoma / pathology. Mouth Neoplasms / pathology. Palate, Hard

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  • (PMID = 17468719.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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58. Silva GC, Vieira TC, Vieira JC, Martins CR, Silva EC: Congenital granular cell tumor (congenital epulis): a lesion of multidisciplinary interest. Med Oral Patol Oral Cir Bucal; 2007 Oct;12(6):E428-30

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  • [Title] Congenital granular cell tumor (congenital epulis): a lesion of multidisciplinary interest.
  • Congenital granular cell tumor (CGCT), or congenital epulis, is a very uncommon benign soft tissue lesion that usually arises from the alveolar mucosa of neonates and may cause respiratory and feeding problems.
  • We report a case of a 3-day-old female newborn, who presented an intraoral tumor mass which was protruding from her mouth, and compromising feeding.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital

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  • (PMID = 17909507.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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59. Manjunatha BS, Pateel GS, Shah V: Oral fibrolipoma-a rare histological entity: report of 3 cases and review of literature. J Dent (Tehran); 2010;7(4):226-31

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  • [Title] Oral fibrolipoma-a rare histological entity: report of 3 cases and review of literature.
  • Lipomas are rare benign soft tissue mesenchymal neoplasms in the oral cavity, representing 1% of all benign oral tumors.
  • To the best of our knowledge a review of the English literature showed 33 cases of FL affecting the oral cavity.The diagnosis and differentiation of FL with clinically similar lesions such as fibroma, mucocele and pleomorphic adenoma are very essential for a correct treatment plan and complete follow-up.
  • Due to the rarity of oral cavity fibrolipoma reports, three cases and a review of literature is presented here.

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  • (PMID = 21998799.001).
  • [ISSN] 2008-2185
  • [Journal-full-title] Journal of dentistry (Tehran, Iran)
  • [ISO-abbreviation] J Dent (Tehran)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3184759
  • [Keywords] NOTNLM ; Adipocytes / Adipose Tissue Neoplasms / Buccal Mucosa / Lipoma
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60. Cardoso CL, Tolentino Ede S, Capelozza AL, Consolaro A: Schwannoma in the lower lip mucosa: unexpected diagnosis. Quintessence Int; 2010 Oct;41(9):769-71
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  • [Title] Schwannoma in the lower lip mucosa: unexpected diagnosis.
  • Schwannoma is a benign tumor arising from nerve-sheath Schwann cells.
  • When it affects the mouth, the lips are rarely involved.
  • Although rare, schwannoma should be considered in the differential diagnosis of any nodule or mass in the oral mucosa.
  • [MeSH-major] Lip Neoplasms / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Antigens, CD34 / analysis. Cell Nucleus / ultrastructure. Diagnosis, Differential. Humans. Male. Middle Aged. Mouth Mucosa / pathology. S100 Proteins / analysis

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  • (PMID = 20806101.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / S100 Proteins
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61. Zarovnaya E, Black C: Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med; 2005 Aug;129(8):1032-6
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  • RESULTS: We found increased nuclear staining of the invasive tumor cells with p53.
  • There was decreased staining within invasive tumor nests with E-cadherin.
  • There was highly significant increased staining within tumor cells and adjacent stroma with matrix metalloproteinase 1 (P < .001).
  • It appeared fragmented in benign inflamed and malignant areas and therefore was not useful.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Granular Cell Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Mouth Mucosa / pathology. Skin Diseases / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Cadherins / metabolism. Child. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Immunoenzyme Techniques. Male. Matrix Metalloproteinase 1 / metabolism. Middle Aged. Tumor Suppressor Protein p53 / metabolism


62. Oliveira RC, Marques KD, Mendonça AR, Mendonça EF, Silva MR, Batista AC, Ribeiro-Rotta RF: Chondrosarcoma of the temporomandibular joint: a case report in a child. J Orofac Pain; 2009;23(3):275-81
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  • Chondrosarcoma is a malignant cartilaginous neoplasm that resembles synovial chondromatosis.
  • The present case was of an 11-year-old girl referred to an Oral Disease Center and presenting with a preauricular swelling on the right side and normal ENT evaluation.
  • Discrete pain and mild limitation of mouth opening were observed.
  • Microscopic findings showed a tumor exhibiting cartilaginous tissue proliferation with cellular pleomorphism, nuclear hyperchromasia, and mixoid changes in the matrix.
  • It is concluded that cartilaginous lesions in the jaws must be regarded with suspicion, since benign and malignant lesions may show similar clinical features.
  • [MeSH-minor] Child. Cyclin B / analysis. Cyclin B1. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Mandibular Condyle / pathology. Temporomandibular Joint / pathology

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  • (PMID = 19639107.001).
  • [ISSN] 1064-6655
  • [Journal-full-title] Journal of orofacial pain
  • [ISO-abbreviation] J Orofac Pain
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCNB1 protein, human; 0 / Cyclin B; 0 / Cyclin B1; 0 / Ki-67 Antigen
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63. Iatrou IA, Theologie-Lygidakis N, Leventis MD: Case report: desmoplastic fibroma of the mandible in a child presenting with TMJ dysfunction. Eur Arch Paediatr Dent; 2008 Jun;9(2):105-8
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  • BACKGROUND: Desmoplastic fibroma of bone is a rare intraosseous benign but locally aggressive tumor of connective tissue origin.
  • CASE REPORT: A 10-year-old boy initially presented with restriction and deviation of mouth opening.
  • Clinical and radiological examination revealed a tumor-like lesion of the mandible extending into the soft tissues, which on biopsy proved to be a desmoplastic fibroma.
  • CONCLUSION: Changes in mouth opening when not attributed to obvious reasons, such as trauma, should make a dentist suspicious and lead to further investigation.
  • Extended surgical removal of the tumor, with wide margins, proved to be the appropriate treatment.
  • [MeSH-major] Fibroma, Desmoplastic / complications. Mandibular Neoplasms / complications. Temporomandibular Joint Disorders / etiology

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  • (PMID = 18534181.001).
  • [ISSN] 1818-6300
  • [Journal-full-title] European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
  • [ISO-abbreviation] Eur Arch Paediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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64. Caltabiano R, Cappellani A, Di Vita M, Lanzafame S: The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. J Craniofac Surg; 2008 Nov;19(6):1691-4
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  • [Title] The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study.
  • We report a case of a 47-year-old man with a granular cell tumor (GCT) of the tongue colocalized with a squamous cell carcinoma.
  • Clinicians and pathologists must be made aware of this potential diagnostic pitfall so that the workup of a tongue lesion does not end prematurely with a benign diagnosis of granular cell tumor with overlying pseudoepitheliomatous hyperplasia.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Epithelium / pathology. Follow-Up Studies. Humans. Hyperplasia. Immunohistochemistry. Male. Membrane Proteins / analysis. Middle Aged. Mouth Mucosa / pathology. Neoplasm Invasiveness. S100 Proteins / analysis

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  • (PMID = 19098584.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins
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65. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L: Myopericytoma: report of two cases associated with trauma. J Cutan Pathol; 2008 Sep;35(9):866-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Myopericytoma is a rare, recently described tumor demonstrating a hemangiopericytoma-like vascular pattern.
  • Despite sharing morphologic features with angioleiomyoma, myofibroma and glomus tumor, myopericytoma is thought to represent a distinct perivascular myoid neoplasm of skin and soft tissues.
  • The tumor is characterized by a radial and perivascular arrangement of ovoid, spindled to round neoplastic cells that are immunoreactive to alpha-smooth muscle actin, often for h-caldesmon as well as smooth muscle myosin-heavy chain, and usually negative for desmin antibodies.
  • Most cases of myopericytoma are benign, however, local recurrence and malignancy have recently been reported, Myopericytoma can be multifocal involving a single or multiple anatomic regions, and tends to occur in dermal and superficial soft tissues of adults primarily on the extremities.
  • [MeSH-major] Hemangiopericytoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology. Wounds and Injuries / complications
  • [MeSH-minor] Actins / metabolism. Aged. Biomarkers, Tumor / metabolism. Calcium-Binding Proteins / metabolism. Female. Humans. Male. Microfilament Proteins / metabolism. Middle Aged. Mouth Mucosa / injuries. Myosin Heavy Chains / metabolism. Nose / injuries. Treatment Outcome

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  • (PMID = 18494828.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Microfilament Proteins; 0 / calponin; EC 3.6.4.1 / Myosin Heavy Chains
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66. Yalçin F, Yalçin S, Berber L, Gür H: Peripheral giant cell granuloma combined with facial hemangioma. A case report. J Int Acad Periodontol; 2005 Oct;7(4):108-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Peripheral giant cell granuloma (PGCG) is a relatively uncommon benign tumor of the oral cavity affecting people of all ages and with no racial predilection.
  • Hemangioma is a benign process in which there are an increased number of normal or abnormal-appearing blood vessels.
  • [MeSH-major] Facial Neoplasms / complications. Gingival Diseases / complications. Granuloma, Giant Cell / complications. Hemangioma / complications. Skin Neoplasms / complications

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  • (PMID = 16245641.001).
  • [ISSN] 1466-2094
  • [Journal-full-title] Journal of the International Academy of Periodontology
  • [ISO-abbreviation] J Int Acad Periodontol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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67. Ongkeko WM, Altuna X, Weisman RA, Wang-Rodriguez J: Expression of protein tyrosine kinases in head and neck squamous cell carcinomas. Am J Clin Pathol; 2005 Jul;124(1):71-6
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  • Formalin-fixed, paraffin-embedded tumor blocks from 44 consecutive patients with primary HNSCC and 5 specimens of benign pharyngeal and laryngeal mucosa were retrieved for immunohistochemical analysis.
  • The study included 21 pharyngeal (base of tongue, 14; tonsil, 6; soft palate, 1), 16 laryngeal, and 1 floor of the mouth carcinoma.
  • All 4 kinases in the tumor samples were expressed highly (PDGFR, 95%-100%; EGFR, 38%-43%; c-kit, 50%-86%; p-Akt, 57%-81%), with EGFR, c-kit, and p-Akt significantly higher than in benign samples.
  • [MeSH-major] Biomarkers, Tumor / analysis. Head and Neck Neoplasms / enzymology. Neoplasms, Squamous Cell / enzymology. Protein-Tyrosine Kinases / biosynthesis

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  • [CommentIn] Am J Clin Pathol. 2006 Oct;126(4):618 [17019796.001]
  • (PMID = 15923166.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor; EC 2.7.11.1 / AKT1 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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68. Beil CM, Keberle M: Oral and oropharyngeal tumors. Eur J Radiol; 2008 Jun;66(3):448-59
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  • [Title] Oral and oropharyngeal tumors.
  • There is a large variability of tumors and tumor-like lesions, which are located in the oral cavity and oropharynx.
  • But more than 90% of all tumors in this area are squamous cell carcinomas (SCCs).
  • About 10% of all oral and oropharyngeal tumors are benign.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Diagnostic Imaging. Mouth Neoplasms / diagnosis. Oropharyngeal Neoplasms / diagnosis
  • [MeSH-minor] Contrast Media. Humans. Mouth / pathology

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  • (PMID = 18457933.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 18
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69. Zätterström U, Thor A, Nordgren H: Cervical metastasis from Spitz nevus of the buccal mucosa. Melanoma Res; 2008 Feb;18(1):36-9
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  • Cytology from fine needle aspiration indicated spread of a melanocytic tumor and she underwent a modified supraomohyiod neck dissection.
  • One of the lymph nodes showed an inclusion of cells in the deep layers with epitheloid and spindle cells in a pattern similar to that of the primary oral lesion.
  • It is believed that this may be an example of how a Spitz tumor, although inherently benign, can spread along lymphatics in a pseudometastatic fashion.
  • To our knowledge this is the first report of an oral Spitz melanoma with metastatic behavior.
  • [MeSH-major] Head and Neck Neoplasms / secondary. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Nevus, Epithelioid and Spindle Cell / pathology

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  • (PMID = 18227706.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. Vescovi P, Corcione L, Meleti M, Merigo E, Fornaini C, Manfredi M, Bonanini M, Govoni P, Rocca JP, Nammour S: Nd:YAG laser versus traditional scalpel. A preliminary histological analysis of specimens from the human oral mucosa. Lasers Med Sci; 2010 Sep;25(5):685-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nd:YAG laser versus traditional scalpel. A preliminary histological analysis of specimens from the human oral mucosa.
  • Hyperplastic fibro-epithelial lesions are the most common tumor-like swellings in the mouth.
  • Some controversies of laser surgery concern the accuracy of pathological diagnosis as well as the control of thermal damage on the target tissue.
  • The aim of this study was to establish if the thermal changes induced by the Nd:YAG laser may affect the histopathological diagnosis and the evaluation of the resection margins.
  • Furthermore, we compared the histological features of oral benign fibro-epithelial lesions excised through Nd:YAG laser and traditional scalpel.
  • Twenty-six benign fibro-epithelial oral lesions from 26 patients, localized in the same oral subsites (cheek and buccal mucosa), were collected at the Unit of Oral Pathology and Oral Laser-assisted Surgery of the Academic Hospital of the University of Parma, Italy.
  • [MeSH-major] Laser Therapy. Lasers, Solid-State / therapeutic use. Mouth Mucosa / surgery. Oral Surgical Procedures / methods

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  • [Cites] Br Dent J. 2007 Feb 24;202(4):185-91 [17322842.001]
  • (PMID = 20393771.001).
  • [ISSN] 1435-604X
  • [Journal-full-title] Lasers in medical science
  • [ISO-abbreviation] Lasers Med Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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71. Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 13 expression in salivary gland tumors. Int J Biol Markers; 2006 Apr-Jun;21(2):106-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human kallikrein 13 expression in salivary gland tumors.
  • The aim of this study was to determine whether hK13 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of hK13.
  • Ductal cells and cells lining duct-like structures showed a higher intensity of staining than non-ductal cells in most tumors.
  • Tumors which exhibited only non-ductal cells also exhibited cytoplasmic staining.
  • In conclusion, we demonstrate the high expression of hK13 in several common salivary gland tumors.
  • [MeSH-major] Biomarkers, Tumor. Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic. Kallikreins / biosynthesis. Mouth Mucosa / metabolism. Salivary Gland Neoplasms / genetics

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  • (PMID = 16847813.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK13 protein, human; EC 3.4.21.- / Kallikreins
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72. Soares CP, Zuanon JA, Teresa DB, Fregonezi PA, Neto CB, Oliveira MR, Donadi EA, Martinelli-Kläy CP, Soares EG: Quantitative cell-cycle protein expression in oral cancer assessed by computer-assisted system. Histol Histopathol; 2006 07;21(7):721-8
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  • [Title] Quantitative cell-cycle protein expression in oral cancer assessed by computer-assisted system.
  • The knowledge of cell-cycle control has shown that the capacity of malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth.
  • Histologic diagnosis might be improved by a quantitative evaluation of more specific diagnosis biomarkers, which could help to precisely identify pre-malignant and malignant oral lesions.
  • The aim of the present study is to evaluate whether computer-based quantitative assessment of p53, PCNA and Ki-67 immunohistochemical expression, could be used clinically to foresee the risk of oral malignant transformation.
  • This retrospective study was carried out in ninety-five oral biopsies, 27 were classified as fibrous inflammatory hyperplasia, 40 as leukoplakia and 28 as oral squamous cell carcinoma.
  • Sixteen out of the 40 leukoplakia were diagnosed as non-dysplastic leukoplakia, the other 24 being dysplastic leukoplakia, of which 50.0% were classified as moderate to severe dysplasia.
  • Comparison of the four groups of oral tissues showed significant rises in p53 and Ki-67 positivity index, which increased steadily in the order benign, pre-malignant, and malignant.
  • In contrast, it was not possible to relate higher PCNA levels with pre-malignant and malignant oral lesions.
  • We therefore conclude that PCNA immunohistochemistry expression is probably an inappropriate marker to identify oral carcinogenesis, whereas joint quantitative evaluation of p53 and Ki-67, appears to be useful as a tumor marker, providing a pre-diagnostic estimate of the potential for cell-cycle deregulation of the oral proliferate status.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Cycle Proteins / metabolism. Diagnosis, Computer-Assisted. Leukoplakia, Oral / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Immunoenzyme Techniques. Ki-67 Antigen / metabolism. Proliferating Cell Nuclear Antigen / metabolism. Retrospective Studies. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16598671.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
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73. Patsiaoura K, Anagnostou E, Benis N: Intramuscular myxoma of the nasal vestibule. Auris Nasus Larynx; 2010 Feb;37(1):100-2

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  • Intramuscular myxoma is an uncommon benign soft tissue neoplasm and a distinct histopathological entity within the heterogeneous group of myxomas.
  • We report on a case of a myxoma within the mimetic muscles of the nasal and mouth region in a 52-year-old man.
  • The tumor was surgically removed and the patient is free of recurrence or complications 8 months after treatment.
  • To the very best of our knowledge, there is no report of this neoplasm located within the nasal and oral mimetic muscles.
  • [MeSH-major] Muscle, Skeletal / pathology. Myxoma / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Nasal Cavity. Otorhinolaryngologic Surgical Procedures. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19414229.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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74. Becker S, Schön R, Gutwald R, Otten JE, Maier W, Hentschel R, Jüttner E, Gellrich NC: A congenital teratoma with a cleft palate: report of a case. Br J Oral Maxillofac Surg; 2007 Jun;45(4):326-7
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  • Teratomas are benign tumors containing cells from ectodermal, mesodermal and endodermal layers.
  • Congenital epignathus teratomas are rare embryological neoplasms localised in the region of head and neck.
  • Size and location of the neoplasm in the oronasopharynx is variable.
  • The epignathus presented as a huge mass extending out of the mouth of the infant girl.
  • On the day of birth debulking of the extraoral portion of the tumor, followed by intraoral exstirpation, was performed.
  • [MeSH-major] Cleft Palate / etiology. Skull Base Neoplasms / congenital. Teratoma / congenital
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Infant, Newborn. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / congenital. Nose Neoplasms / pathology

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  • (PMID = 16377040.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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75. Vigneswaran N, Beckers S, Waigel S, Mensah J, Wu J, Mo J, Fleisher KE, Bouquot J, Sacks PG, Zacharias W: Increased EMMPRIN (CD 147) expression during oral carcinogenesis. Exp Mol Pathol; 2006 Apr;80(2):147-59
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  • [Title] Increased EMMPRIN (CD 147) expression during oral carcinogenesis.
  • Gene expression profiling of oral premalignant (OPM) cells and normal oral epithelial (NOR) cells showed that EMMPRIN expression was markedly upregulated in OPM cells compared to NOR cells.
  • We used an oral squamous cell carcinoma (OSCC) progression model composed of cell lines, organotypic cultures and tissue specimens to characterize EMMPRIN expression patterns by microarray analysis, qRT-PCR, Western blotting and immunohistochemistry.
  • EMMPRIN expression was limited to basal cells of normal, benign hyperkeratotic and inflammatory (lichen planus) oral mucosa.
  • These results suggest that EMMPRIN overexpression occurs at a very early stage of oral carcinogenesis and plays a contributing role in OSCC tumorigenesis.
  • [MeSH-major] Antigens, CD147 / genetics. Gene Expression Regulation, Neoplastic. Mouth Neoplasms / genetics. Up-Regulation / genetics
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell. Cell Line, Tumor. Epithelial Cells / cytology. Female. Gene Expression Profiling. Humans. Keratinocytes / cytology. Leukoplakia, Oral / pathology. Microarray Analysis. Middle Aged. Mouth Mucosa / pathology. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 16310185.001).
  • [ISSN] 0014-4800
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE13150; United States / NIDCR NIH HHS / DE / DE14395
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 136894-56-9 / Antigens, CD147
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76. Schmidt LA, Olsen SH, McHugh JB: Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy. Am J Surg Pathol; 2010 Aug;34(8):1205-10
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  • Cutaneous adnexal differentiation is well-recognized in benign mixed tumors occurring in cutaneous sites.
  • We sought to describe the incidence of cutaneous adnexal differentiation in benign mixed tumors of the palate, lip, and parotid gland.
  • Benign mixed tumors of the palate (n=30), lip (n=13), and parotid gland (n=37) resected between 1980 and 2009 at a single academic medical institution were reviewed.
  • All hematoxylin and eosin-stained sections containing neoplasm were reviewed by all authors including one dermatopathologist (S.H.O.).
  • After confirming the diagnosis of benign mixed tumor, we evaluated for morphologic evidence of cutaneous adnexal differentiation and metaplastic epithelial and stromal changes.
  • Cutaneous adnexal differentiation was seen in 20% of palate and 39% of lip benign mixed tumors but in no parotid tumors.
  • The most frequent features of cutaneous adnexal differentiation were tricholemmal differentiation (20% of palate and 39% of lip tumors), infundibulocystic structures (17% and 31%), and trichohyalin granules (13% and 31%).
  • Sebaceous differentiation was seen in only one palate tumor.
  • Varying amounts of stromal adipose were seen in 62, 37, and 22% of lip, palate, and parotid tumors.
  • Osseous metaplasia was seen in one tumor from each site.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Cell Differentiation. Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Mouth Neoplasms / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Lip Neoplasms / pathology. Male. Metaplasia. Middle Aged. Palatal Neoplasms / pathology. Parotid Neoplasms / pathology. Young Adult

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  • (PMID = 20661019.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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77. Canjuga I, Mravak-Stipetić M, Kopić V, Galić J: Oral acanthosis nigricans: case report and comparison with literature reports. Acta Dermatovenerol Croat; 2008;16(2):91-5
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  • [Title] Oral acanthosis nigricans: case report and comparison with literature reports.
  • Acanthosis nigricans (AN) is a rare condition which may affect oral cavity.
  • There are two forms of AN: benign and malignant.
  • Benign AN may be hereditary, or may be related to systemic diseases or drugs.
  • Oral lesions occurred after the tumor had been diagnosed, i.e. after third operation for tumor recurrence.
  • The fifth operation for tumor recurrence resulted in slight improvement of oral changes.
  • It is concluded that the severity of oral changes is in correlation with tumor progression.
  • The occurrence of oral lesions may be an indicator of tumor progression.
  • [MeSH-major] Acanthosis Nigricans / etiology. Acanthosis Nigricans / pathology. Carcinoma, Transitional Cell / complications. Mouth Diseases / etiology. Mouth Diseases / pathology. Urinary Bladder Neoplasms / complications
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Neoplasm Recurrence, Local / surgery. Reoperation. Severity of Illness Index

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  • (PMID = 18541106.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 20
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78. Nieman LT, Kan CW, Gillenwater A, Markey MK, Sokolov K: Probing local tissue changes in the oral cavity for early detection of cancer using oblique polarized reflectance spectroscopy: a pilot clinical trial. J Biomed Opt; 2008 Mar-Apr;13(2):024011
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  • [Title] Probing local tissue changes in the oral cavity for early detection of cancer using oblique polarized reflectance spectroscopy: a pilot clinical trial.
  • We report the results of an oral cavity pilot clinical trial to detect early precancer and cancer using a fiber optic probe with obliquely oriented collection fibers that preferentially probe local tissue morphology and heterogeneity using oblique polarized reflectance spectroscopy (OPRS).
  • Without stratifying the data according to anatomical location or level of keratinization, OPRS is found to be sensitive to four diagnostic categories: normal, benign, mild dysplasia, high-grade dysplasia, and carcinoma.
  • Separation of visually indistinguishable benign lesions from high-grade dysplasia and carcinoma is achieved with good sensitivity (100%) and specificity (85%), while separation of benign from mild dysplasia gives a sensitivity of 92% and a specificity of 69%.
  • These promising results suggest that OPRS has the potential to aid screening and diagnosis of oral precancer and cancer.
  • [MeSH-major] Biomarkers, Tumor / analysis. Diagnosis, Computer-Assisted / methods. Mouth Neoplasms / diagnosis. Mouth Neoplasms / metabolism. Photometry / methods. Refractometry / methods. Spectrum Analysis / methods

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  • (PMID = 18465974.001).
  • [ISSN] 1083-3668
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / EB003540
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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79. Yu Y, Feng YY, Yuan RT, Wang N, Zhao BD, Jia MY: [Osteoma in the soft palate: report of one case and review of the literature]. Shanghai Kou Qiang Yi Xue; 2007 Oct;16(5):555-6
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  • Osteoma is a benign tumor, which is composed of mature differentiated bone tissue and derived from osteoplast in periosteum endothecium.
  • The clinical manifestation, differential diagnosis, pathologic diagnosis and treatment were discussed.
  • [MeSH-major] Mouth Neoplasms / diagnosis. Osteoma / diagnosis. Palate, Soft / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 18004493.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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80. El-Sayed IH, Huang X, El-Sayed MA: Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles. Cancer Lett; 2006 Jul 28;239(1):129-35
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  • Two oral squamous carcinoma cell lines (HSC 313 and HOC 3 Clone 8) and one benign epithelial cell line (HaCaT) were incubated with anti-epithelial growth factor receptor (EGFR) antibody conjugated gold nanoparticles and then exposed to continuous visible argon ion laser at 514nm.
  • It is found that the malignant cells require less than half the laser energy to be killed than the benign cells after incubation with anti-EGFR antibody conjugated Au nanoparticles.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Carcinoma, Squamous Cell / therapy. Gold / chemistry. Hyperthermia, Induced / methods. Low-Level Light Therapy / methods. Mouth Neoplasms / therapy. Nanostructures / chemistry. Receptor, Epidermal Growth Factor / immunology
  • [MeSH-minor] Epithelial Cells / radiation effects. Humans. Immunoconjugates. Tumor Cells, Cultured

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  • (PMID = 16198049.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoconjugates; 7440-57-5 / Gold; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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81. Gupta N, Rajwanshi A, Mohindra S, Vasishta RK, Batra C, Gupta AK: Diagnosis of adult rhabdomyoma by fine needle aspiration cytology: a report of 2 cases. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):968-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of adult rhabdomyoma by fine needle aspiration cytology: a report of 2 cases.
  • BACKGROUND: Adult rhabdomyoma (ARh) is a rare, benign tumor originating in striated muscle cells.
  • Ninety-three percent of the tumors occur in the head and neck region and sometimes mimic malignant tumors clinically.
  • The preoperative correct diagnosis of this tumor is important as it can help in deciding on management.
  • Case 1 was a 43-year-old male who presented with a recurrent tumor in the region of the floor of the mouth.
  • On cytology in both cases, the smears showed numerous large tissue fragments of tumor cells, which were large, polygonal cells with abundant, vacuolated cytoplasm and bland, eccentrically placed nuclei.
  • CONCLUSION: ARh has characteristic cytomorphologic features, which are described in detail in the present report, and they can help in diagnosing this tumor on FNAC.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / pathology. Mouth Neoplasms / diagnosis. Mouth Neoplasms / pathology. Rhabdomyoma / diagnosis. Rhabdomyoma / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Magnetic Resonance Imaging. Male. Mandible / pathology. Mouth / pathology. Tomography, X-Ray Computed

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  • (PMID = 21053579.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Kim SK, Won HS, Lee SW, Kim JK, Shim JY, Lee PR, Kim A: Prenatal diagnosis of congenital epulis by three-dimensional ultrasound and magnetic resonance imaging. Prenat Diagn; 2006 Feb;26(2):171-4
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  • [Title] Prenatal diagnosis of congenital epulis by three-dimensional ultrasound and magnetic resonance imaging.
  • Congenital epulis is a benign intraoral tumor that has rarely been diagnosed prenatally.
  • [MeSH-major] Fetal Diseases / diagnosis. Granular Cell Tumor / diagnosis. Imaging, Three-Dimensional / methods. Magnetic Resonance Imaging / methods. Mouth Neoplasms / diagnosis. Prenatal Diagnosis

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  • [Copyright] Copyright 2006 John Wiley & Sons, Ltd.
  • (PMID = 16470675.001).
  • [ISSN] 0197-3851
  • [Journal-full-title] Prenatal diagnosis
  • [ISO-abbreviation] Prenat. Diagn.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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83. Fukunari F, Okamura K, Zeze R, Kagawa T, Hashimoto K, Yuasa K: Cervical lymph nodes with or without metastases from oral squamous carcinoma: a correlation of MRI findings and histopathologic architecture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jun;109(6):890-9
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  • [Title] Cervical lymph nodes with or without metastases from oral squamous carcinoma: a correlation of MRI findings and histopathologic architecture.
  • OBJECTIVES: The aim of this study was to describe the magnetic resonance images (MRIs) of the architecture of metastatic lymph nodes as well as healthy lymph nodes and to correlate the images with the histopathologic architecture of the lymph nodes from oral squamous cell carcinoma.
  • STUDY DESIGN: The signal intensities of 98 cervical lymph nodes from 20 patients with oral squamous cell carcinoma were evaluated on T2-weighted and diffusion-weighted whole-body imaging with background body signal suppression (DWIBS).
  • RESULTS: On T2-weighted images, very hyperintense and/or isointense areas were specific findings for lymph nodes containing metastases from oral squamous cell carcinoma.
  • Using DWIBS images with inverted black-and-white image contrast, cystic degeneration, keratinization, fibrous tissue, tumor tissue, and lymphoid tissue were either hypointense or intermediate in intensity.
  • CONCLUSIONS: On T2-weighted images, very hyperintense and/or isointense areas were characteristic findings for lymph nodes containing metastases from oral squamous cell carcinoma.
  • Using DWIBS images, it was difficult to differentiate metastatic from benign lymph nodes.
  • [MeSH-major] Lymph Nodes / radiography. Lymphatic Metastasis / radiography. Magnetic Resonance Imaging. Mouth Neoplasms / pathology. Neoplasms, Squamous Cell / radiography

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20299250.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Ogmundsdóttir HM, Björnsson J, Holbrook WP: Role of TP53 in the progression of pre-malignant and malignant oral mucosal lesions. A follow-up study of 144 patients. J Oral Pathol Med; 2009 Aug;38(7):565-71
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  • [Title] Role of TP53 in the progression of pre-malignant and malignant oral mucosal lesions. A follow-up study of 144 patients.
  • BACKGROUND: Prediction of progression from pre-malignant oral mucosal lesions to malignancy, or recurrence of an existing oral squamous cell carcinoma (OSCC), is an important clinical problem in oral medicine.
  • Samples from 54 patients with OSCC, 45 with oral lichen planus (OLP) and 45 with hyperkeratosis (clinically leukoplakia), diagnosed between 1987 and 1996, were analysed for TP53 protein expression and TP53 mutation.
  • One hyperkeratosis patient (non-mutated) developed OSCC in the same site.
  • CONCLUSION: TP53 mutations can exist in benign oral mucosal lesions for many years without progression to malignancy.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Leukoplakia, Oral / metabolism. Lichen Planus, Oral / metabolism. Mouth Neoplasms / metabolism. Precancerous Conditions / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Mouth Mucosa / metabolism. Mutation. Survival Analysis

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  • (PMID = 19473450.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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85. He H, Chen G, Zhou L, Liu Y: A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland. J Cancer Res Clin Oncol; 2009 Oct;135(10):1315-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland.
  • OBJECTIVE: To detect the levels of carcinoembryonic antigen (CEA) and carcinoma associated antigen CA-50 in the patients with oral or salivary malignant tumors.
  • METHODS: The concentrations of salivary CEA and CA-50 were assayed in 80 patients of oral and salivary malignant tumors, 40 patients of benign tumors and 80 health controls.
  • In 80 patients with malignant tumors, serum CEA and CA-50 were also assayed by enzyme-linked immunoabsorbent assay and immunoradiometric analysis, respectively.
  • RESULTS: Salivary CEA and CA-50 levels were significantly higher in malignant tumors than in benign tumors and in health controls, respectively (P < 0.001).
  • Only 7 cases and 3 cases of 80 patients with malignant tumors were found having increased serum CEA and CA-50 levels, respectively.
  • This may be more useful as prognostic indicators in early diagnosis of oral and salivary malignant tumors.
  • [MeSH-major] Adenoma / blood. Antigens, Tumor-Associated, Carbohydrate / analysis. Carcinoembryonic Antigen / analysis. Mouth Neoplasms / blood. Saliva / chemistry. Salivary Gland Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunoradiometric Assay. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Young Adult

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  • [Cites] J Surg Oncol. 2001 Dec;78(4):253-8 [11745820.001]
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  • (PMID = 19322585.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / CA-50 antigen; 0 / Carcinoembryonic Antigen
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86. Moreira PR, Guimarães MM, Guimarães AL, Diniz MG, Gomes CC, Brito JA, Gomez RS: Methylation of P16, P21, P27, RB1 and P53 genes in odontogenic keratocysts. J Oral Pathol Med; 2009 Jan;38(1):99-103
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  • BACKGROUND: Odontogenic keratocyst (OKC) is a benign neoplasm with an aggressive clinical behavior and a high recurrence rate.
  • Although epigenetic alterations have been reported in different tumors, these events were not investigated in OKC yet.
  • The aim of this study was to investigate the presence of methylation in P16, P21, P27, P53 and RB1 genes in OKC tumors.
  • METHODS: Methylation-specific polymerase chain reaction (MSP) was used to evaluate the presence of methylation in 10 samples of OKCs, 10 samples of dental follicles and six samples of normal mucosa.
  • [MeSH-major] DNA Methylation / genetics. Genes, Tumor Suppressor. Odontogenic Cysts / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Cyclin-Dependent Kinase Inhibitor p21 / genetics. Cyclin-Dependent Kinase Inhibitor p27 / genetics. Dental Sac / metabolism. Epigenesis, Genetic / genetics. Female. Genes, p16. Genes, p53. Humans. Male. Mouth Mucosa / metabolism. Promoter Regions, Genetic / genetics. Retinoblastoma Protein / genetics. Young Adult

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  • (PMID = 19192054.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Retinoblastoma Protein; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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87. Elarbi M, El-Gehani R, Subhashraj K, Orafi M: Orofacial tumors in Libyan children and adolescents. A descriptive study of 213 cases. Int J Pediatr Otorhinolaryngol; 2009 Feb;73(2):237-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orofacial tumors in Libyan children and adolescents. A descriptive study of 213 cases.
  • AIM: The aim of this study was to determine the relative frequency of orofacial tumors and tumor like lesions in Libyan children and adolescents, and compare our findings with reports in the literature.
  • METHODS: A total of 213 cases of tumors and tumor like lesions were seen in patients aged 18 years and less during a period of 17 years.
  • RESULTS: There were 8 cases (3.7%) of malignant tumors in our study, 35 cases (16.4%) of benign odontogenic tumors and 170 cases (89%) of benign tumors and tumor like lesions of orofacial region were seen in this study. orofacial tumors are not uncommon among the Libyan children and adolescents.
  • CONCLUSION: A slightly lower incidence of malignant tumors was observed as a result of the less number of cases of Burkitt's lymphoma, in comparison to other reports from Africa.
  • [MeSH-major] Facial Neoplasms / epidemiology. Mouth Neoplasms / epidemiology

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  • (PMID = 19070371.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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88. Driemel O, Kunkel M, Hullmann M, Kleinsasser N, Staudenmaier R, Müller-Richter U, Reichert TE, Kosmehl H: [Performance of conventional oral brush biopsies]. HNO; 2008 Feb;56(2):205-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Performance of conventional oral brush biopsies].
  • [Transliterated title] Wertigkeit der konventionellen oralen Bürstenbiopsie.
  • BACKGROUND: This study evaluated the performance of oral brush biopsies using standard morphological analysis and haematoxylin and eosin (HE) staining for detecting oral squamous cell carcinomas and their respective precursor lesions PATIENTS AND METHODS: Brush biopsies were obtained in 169 consecutive patients who underwent routine biopsies and histological examination for clinically suspicious oral lesions.
  • Cytological assessment used well-established criteria of atypia to classify the specimen as either "tumor negative" (no signs of atypia, no malignant cells) or "tumor positive" (malignant cells, any sign of atypia or doubtful cells).
  • RESULTS: Despite a sufficient number of cells, a definite cytological diagnosis could not be established in six cases.
  • According to the criteria specified above, these specimens were classified as "tumor positive."
  • The cytological analysis identified 49 out of 62 oral malignancies (sensitivity 79%).
  • Seven out of 107 benign lesions were classified as false positive (specificity 93%).
  • CONCLUSION: Oral brush biopsies will identify only about 80% of oral malignancies when the smears are processed by routine HE stains and are analysed via standard morphological criteria.
  • However, oral brush biopsy provides a versatile back-up strategy to uncover the true nature of the disease if a lesion is clinically considered benign by mistake.
  • [MeSH-major] Biopsy / methods. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology

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  • (PMID = 18214406.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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89. Rabbels J, Scheer M, Heibel H, Wickenhauser C, Kübler AC: [Neurinoma of the hard palate in an 11-year-old girl. Case report]. Mund Kiefer Gesichtschir; 2005 Nov;9(6):400-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Neurinom des harten Gaumens bei einem elfjährigen Mädchen. Ein Fallbericht.
  • BACKGROUND: Neurinomas or schwannomas are benign, encapsulated growing tumors of the Schwann cells of the nerve sheets; 25-45% are located in the head and neck region.
  • They are found rarely in the oral cavity.
  • Other less common locations are the buccal mucosa, palate, floor of the mouth, gingiva and lips.
  • Because of the benign tumor type we considered the young patient to be healed.
  • [MeSH-major] Neurilemmoma / diagnosis. Palatal Neoplasms / diagnosis. Palate, Hard

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  • (PMID = 16228186.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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90. Salla JT, Johann AC, Lana AM, do Carmo MA, Nunes FD, Mesquita RA: Immunohistochemical study of GLUT-1 in oral peripheral nerve sheath tumors. Oral Dis; 2008 Sep;14(6):510-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical study of GLUT-1 in oral peripheral nerve sheath tumors.
  • AIM: To investigate the immunoexpression and diagnostic applicability of human erythrocyte-type glucose transporter protein (GLUT-1) in oral peripheral nerve sheath tumors.
  • MATERIAL AND METHODS: Specimens diagnosed as oral peripheral nerve sheath tumors archived in the Oral Pathology Service of Universidade Federal de Minas Gerais from 1966 to 2006 were evaluated.
  • Thirty-four lesions were included: 15 traumatic neuromas, 11 neurofibromas, four neurilemmomas, and four malignant peripheral nerve sheath tumors (MPNST).
  • RESULTS: Benign lesions were immunopositive for GLUT-1 except in two (18.2%) cases of neurofibromas.
  • One case (25%) of MPNST presented GLUT-1 positive stain in occasional cells distributed homogeneously in all the tumor area.
  • CONCLUSION: GLUT-1 is a useful marker for perineurial cells and should be included in the oral peripheral nerve sheath tumors immunophenotyping thus aiding in the correct diagnosis of these lesions.
  • [MeSH-major] Glucose Transporter Type 1 / analysis. Mouth Neoplasms / pathology. Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Connective Tissue / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Immunophenotyping. Nerve Fibers / pathology. Neurilemmoma / pathology. Neurofibroma / pathology. Neurofibromatosis 1 / pathology. Neuroma / pathology. S100 Proteins / analysis

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  • [CommentIn] Oral Dis. 2009 Apr;15(3):244; author reply 245 [19335644.001]
  • (PMID = 18826382.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / S100 Proteins
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91. Kim HY, Jung SN, Kwon H, Sohn WI, Moon SH: Angiomyoma in the buccal space. J Craniofac Surg; 2010 Sep;21(5):1634-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyoma is a rare benign tumor originated from vascular smooth muscle cells, in other words, the tunica media, and the characteristic is the detection of numerous blood vessels together with spindle-shape smooth muscle cells.
  • In the head and neck area, it is developed most frequently in the larynx and the turbinates, and in addition, the development in the oral cavity (lip, hard palate, tonsil), nose, ear, cheek, parotid gland, and submandibular region has been reported.
  • [MeSH-major] Angiomyoma / surgery. Mouth Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20856064.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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92. Dalati T, Hussein MR: Juvenile pleomorphic adenoma of the cheek: a case report and review of literature. Diagn Pathol; 2009;4:32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands.
  • About 90% of these tumors occur in the parotid gland and 10% in the minor salivary glands.
  • Other rare sites include the throat, floor of the mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity.
  • To conclude, pleomorphic adenoma should be considered in the differential diagnosis of cheek masses in youngsters.

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  • (PMID = 19772659.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2759908
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93. Bologna-Molina R, Mosqueda-Taylor A, Lopez-Corella E, Almeida OP, Carrasco-Daza D, Garcia-Vazquez F, Farfan-Morales JE, Irigoyen-Camacho ME, Damián-Matsumura P: Syndecan-1 (CD138) and Ki-67 expression in different subtypes of ameloblastomas. Oral Oncol; 2008 Aug;44(8):805-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastoma is the most frequent odontogenic tumor and is considered a benign, but locally invasive, neoplasm with variable clinico-pathological expression.
  • The salient finding was that expression of syndecan-1 was related to the histological subtype of tumors, as there was a lower expression in SA (40.2%) as compared to UA (49.7%) (p<0.05).
  • The lack of correlation between reduction of the syndecan-1 and Ki-67 index may be due to the different histomorphologies of both types of ameloblastoma, and more studies are necessary to better understand the role of this protein in the biological behavior of these tumors.
  • [MeSH-major] Ameloblastoma / metabolism. Ki-67 Antigen / metabolism. Neoplasm Proteins / metabolism. Syndecan-1 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Down-Regulation. Female. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged. Mouth Mucosa / metabolism. Tooth Germ / metabolism. Young Adult

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  • (PMID = 18207448.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Syndecan-1
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94. Driemel O, Dahse R, Berndt A, Pistner H, Hakim SG, Zardi L, Reichert TE, Kosmehl H: High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies. Clin Oral Investig; 2007 Mar;11(1):93-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies.
  • Tumour-invasion like wound healing is characterised by the formation of an extracellular matrix with a high tenascin-C content.
  • Analysis using antibody BC2 indicates that especially the high-molecular tenascin-C (hm tn-C) variants are typically tumour-associated, while distribution in normal tissue is restrictive.
  • This study investigated whether hm tn-C is a suitable indicator of atypical cells with invasive potential in oral brush biopsies.
  • One hundred fifty nine consecutive oral brush biopsies with histopathological diagnoses were analysed for the identification of atypical cells.
  • Conventional cytology produced four false-positives when identifying atypical cells in brush biopsies of inflammatory/benign hyperproliferative mucosa (specificity 96%), while 10 in 52 carcinomas and three of eight recurrences were not identified (sensitivity 78%).
  • Ten of these 13 non-identified tumours could be marked when adding the hm tn-C assay (increasing specificity to 99%).
  • The positive and negative predictive values were 92 and 88% for conventional cytology vs 98 and 97% for the dual assay. (1) A 95%-sensitivity proves hm tn-C assisted conventional cytology to be a suitable means of identifying atypical cells in oral brush biopsies. (2) The positive (98%) and negative (97%) predictive values obtained approximate hm tn-C assisted conventional cytology to laminin-5 (100/97%).
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy / methods. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. Tenascin / analysis
  • [MeSH-minor] Epithelial Cells / pathology. Humans. Immunoenzyme Techniques. Mouth Mucosa / pathology. Neoplasm Invasiveness / pathology. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 17111122.001).
  • [ISSN] 1432-6981
  • [Journal-full-title] Clinical oral investigations
  • [ISO-abbreviation] Clin Oral Investig
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tenascin
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95. Lin C, Li J, Lu N: [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):553-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang].
  • OBJECTIVE: To investigate the incidence and constituent characteristic of neoplasm in oromaxillo-facial region in Xinjiang.
  • METHODS: A total of 2161 patients with benign or malignant oral-maxillofacial tumors diagnosed in Department of Dentofacial Surgery of the First Affiliated Hospital of Xinjiang Medical College from 1995 to 2009 were analyzed retrospectively.
  • RESULTS: Of the 2161 cases, 58.49% (1264/2161) was benign tumors, 33.13% (716/2161) malignant tumors, and 8.38% (181/2161) tumor-like lesions.
  • The most common benign tumors were pleomorphic adenoma, hemangioma, papilloma, adenolymphoma and ameloblastoma.
  • Squamous cell carcinoma constituted the majority of the malignant tumors.
  • The most common malignant tumors of salivary gland were adenoid cystic carcinoma.
  • The most common odontogenic tumors was ameloblastoma.
  • The most common sites of malignant tumors were tongue, lip, parotiod gland and buccal mucosa.
  • CONCLUSIONS: The common pathological type of oral and maxillofacial benign neoplasm and the most common sites of malignancy in Xinjiang region were similar to those of other places inside and outside the country.
  • Adenoid cystic carcinoma was more common than other salivary originated tumors.
  • There was more malignant tumors in Uygur nationality than in Han living in the same region.
  • [MeSH-major] Mouth Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma. Adenoma, Pleomorphic. Ameloblastoma. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. China / epidemiology. Face. Humans. Incidence. Mouth Mucosa. Odontogenic Tumors. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 21122451.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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96. Park YH, Kim SW, Cho SH, Choi YW: Nasopharyngeal glioma causing respiratory distress in a neonate: transoral endoscopic excision. Ear Nose Throat J; 2010 May;89(5):E11-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nasal gliomas are rare, benign, congenital midline tumors made up of heterotopic neuroglial tissue.
  • Preoperative diagnostic imaging is essential to delineate the exact location, limits, and extensions of the tumor and thus to determine the appropriate surgical approach.
  • [MeSH-major] Endoscopy / methods. Glioma / complications. Glioma / surgery. Nasopharyngeal Neoplasms / complications. Nasopharyngeal Neoplasms / surgery. Respiratory Distress Syndrome, Newborn / etiology
  • [MeSH-minor] Humans. Infant, Newborn. Mouth

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  • (PMID = 20461669.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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97. Studart-Soares EC, Costa FW, Sousa FB, Alves AP, Osterne RL: Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e691-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature.
  • OBJECTIVES: Lipomas are common benign mesenchymal neoplasms that rarely occur in the oral cavity and correspond to less than 4.4% of all benign oral soft tissue tumors.
  • This study describes the clinical, radiological and histological features of cases of oral lipomas seen over a period of 10 years and compared the findings with those reported in the literature.
  • STUDY DESIGN: All cases of oral lipomas seen between 1999 and 2009 were retrieved from the archives of the Stomatology Division of the Federal University of Ceará, Brazil.
  • Age, gender, tumor location, clinical findings, duration, histological subtypes, and treatment outcome were recorded.
  • The specific sites involved were the oral mucosa (n=5), vestibule (n=3), gingiva (n=1), and retromolar region (n=1).
  • The mean size of the tumors was 1.94 cm (range 1.0 to 3.0 cm).
  • The duration of the tumors ranged from 2 to 84 months, with a mean duration of 30.4 months.
  • The findings were compared with 450 cases of oral lipomas reported in the literature.
  • CONCLUSIONS: Lipomas continue to be an uncommon neoplasm of the oral cavity.
  • [MeSH-major] Lipoma / diagnosis. Mouth Neoplasms / diagnosis

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  • (PMID = 20383107.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
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98. Kummoona R: The managements of orofacial tumors of children in Iraq. J Craniofac Surg; 2009 Jan;20(1):143-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The managements of orofacial tumors of children in Iraq.
  • These studies were carried out in the maxillofacial unit, surgical specialties hospital, medical city, Baghdad, included 55 patients with orofacial tumors; their ages ranged from 2 days to 14 years (mean, 7 years).
  • Tumors included 20 cases of benign tumors and 35 cases malignant.
  • Treatment modalities ranged from complete surgical excision, surgical shaving operations, and deep x-ray therapy (DXT; radiotherapy) for some benign tumors.
  • The management of malignant tumors was carried out by the use of chemotherapy, chemotherapy and DXT to radical surgery, or radical surgery with DXT.
  • Reconstruction of the mandible was carried out using a rib graft or a block of a corticocancellous bone graft from the iliac crest with reimplantation of the condyle after resection from the tumor and fixed by rigid fixation to the bone graft.
  • Temporary reconstruction of the mandible done by Kirschner wire for malignant tumors required a postsurgical DXT.
  • A temporalis muscle flap was used for the augmentation of the orbit with a frontoorbital flap after radical excision of a malignant tumor of the orbit, and a silastic implant (silicon rubber) was used for reconstruction of the orbital floor.
  • The aim of this study was to present a certain number of cases with an interesting pathologic tumor condition showing peculiar behaviors; the management of these cases was a challenge to our surgical experience.
  • [MeSH-major] Facial Neoplasms / surgery. Mouth Neoplasms / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Transplantation. Chemotherapy, Adjuvant. Child. Child, Preschool. Diagnostic Imaging. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Iraq. Longitudinal Studies. Lymphoma / surgery. Male. Mandibular Condyle / surgery. Mandibular Neoplasms / surgery. Neoadjuvant Therapy. Prostheses and Implants. Radiotherapy, Adjuvant. Reconstructive Surgical Procedures / methods. Skull Neoplasms / surgery. Surgical Flaps. Temporal Muscle / transplantation

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  • (PMID = 19165012.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Ponniah I: A rare case of sialadenoma papilliferum with epithelial dysplasia and carcinoma in situ. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Aug;104(2):e27-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sialadenoma papilliferum is a rare benign tumor of salivary glands that predominantly affects intraoral minor salivary glands.
  • [MeSH-major] Carcinoma in Situ / pathology. Mouth Floor / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 17630095.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Mardi K, Sharma J: Calcifying fibrous pseudotumor of the soft palate--a case report. Indian J Pathol Microbiol; 2006 Jul;49(3):394-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is a rare benign lesion characterized by the presence of abundant hyalinized collagen with psammomatous or dystrophic calcification, and lymphoplasmacytic infiltrate.
  • The mass had all the pathologic features of a calcifying fibrous pseudo-tumor.
  • [MeSH-major] Calcinosis / pathology. Fibrosis / pathology. Mouth Diseases / pathology. Palate, Soft / pathology

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  • (PMID = 17001895.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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