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1. Gkoulioni V, Eleftheriadou A, Yiotakis I, Ferekidou E, Chrisovergis A, Lazaris ACh, Kandiloros D: The efficacy of imiquimod on dysplastic lesions of the oral mucosa: an experimental model. Anticancer Res; 2010 Jul;30(7):2891-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The efficacy of imiquimod on dysplastic lesions of the oral mucosa: an experimental model.
  • AIM: To study the potent efficacy of the immunomodulatory agent imiquimod when applied on dysplastic lesions of the oral mucosa.
  • In one case, a well-differentiated squamous cell carcinoma was converted to a papilloma-like squamous neoplasm with a benign morphology.
  • CONCLUSION: Our results indicate that imiquimod may be effective in treatment of precancerous lesions of the oral mucosa and thus inhibit the progress of carcinogenesis.
  • [MeSH-major] Aminoquinolines / pharmacology. Mouth Neoplasms / prevention & control. Precancerous Conditions / drug therapy
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene. Animals. Antineoplastic Agents / pharmacology. Carcinogens. Carcinoma, Squamous Cell / chemically induced. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Male. Mouth Mucosa / drug effects. Mouth Mucosa / pathology. Rats. Rats, Wistar

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  • (PMID = 20683029.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Carcinogens; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; 99011-02-6 / imiquimod
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2. Heimdal JH, Aarstad HJ, Olsnes C, Olofsson J: Human autologous monocytes and monocyte-derived macrophages in co-culture with carcinoma F-spheroids secrete IL-6 by a non-CD14-dependent pathway. Scand J Immunol; 2001 Feb;53(2):162-70
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  • [Title] Human autologous monocytes and monocyte-derived macrophages in co-culture with carcinoma F-spheroids secrete IL-6 by a non-CD14-dependent pathway.
  • The secretion of interleukin (IL)-1 beta, IL-6 and tumour necrosis factor (TNF)-alpha were compared when freshly isolated autologous monocytes or monocytederived macrophages (MDMs) were co-cultured in vitro with autologous fragment (F)-spheroids established from a series of head and neck squamous cell carcinoma (HNSCC) patients.
  • F-spheroids were generated from the malignant tumour (M-spheroids) or from benign mucosa (B-spheroids) from which the tumour originated control.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hypopharyngeal Neoplasms / pathology. Interleukin-1 / secretion. Interleukin-6 / secretion. Macrophages / secretion. Monocytes / secretion. Mouth Mucosa / cytology. Mouth Neoplasms / pathology. Neoplasm Proteins / secretion. Spheroids, Cellular / cytology. Tumor Necrosis Factor-alpha / secretion
  • [MeSH-minor] Antigens, CD14 / physiology. Cell Differentiation. Cells, Cultured / drug effects. Cells, Cultured / secretion. Coculture Techniques. Gene Expression Regulation / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Humans. Lipopolysaccharides / pharmacology. RNA, Messenger / biosynthesis. RNA, Neoplasm / biosynthesis. Tumor Cells, Cultured / drug effects. Tumor Cells, Cultured / secretion

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  • (PMID = 11169220.001).
  • [ISSN] 0300-9475
  • [Journal-full-title] Scandinavian journal of immunology
  • [ISO-abbreviation] Scand. J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD14; 0 / Interleukin-1; 0 / Interleukin-6; 0 / Lipopolysaccharides; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Tumor Necrosis Factor-alpha
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3. Canjuga I, Mravak-Stipetić M, Kopić V, Galić J: Oral acanthosis nigricans: case report and comparison with literature reports. Acta Dermatovenerol Croat; 2008;16(2):91-5
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  • [Title] Oral acanthosis nigricans: case report and comparison with literature reports.
  • Acanthosis nigricans (AN) is a rare condition which may affect oral cavity.
  • There are two forms of AN: benign and malignant.
  • Benign AN may be hereditary, or may be related to systemic diseases or drugs.
  • Oral lesions occurred after the tumor had been diagnosed, i.e. after third operation for tumor recurrence.
  • The fifth operation for tumor recurrence resulted in slight improvement of oral changes.
  • It is concluded that the severity of oral changes is in correlation with tumor progression.
  • The occurrence of oral lesions may be an indicator of tumor progression.
  • [MeSH-major] Acanthosis Nigricans / etiology. Acanthosis Nigricans / pathology. Carcinoma, Transitional Cell / complications. Mouth Diseases / etiology. Mouth Diseases / pathology. Urinary Bladder Neoplasms / complications
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Neoplasm Recurrence, Local / surgery. Reoperation. Severity of Illness Index

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  • (PMID = 18541106.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 20
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4. Said-Al-Naief N, Zahurullah FR, Sciubba JJ: Oral spindle cell lipoma. Ann Diagn Pathol; 2001 Aug;5(4):207-15
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  • [Title] Oral spindle cell lipoma.
  • Lipoma is an uncommon benign, oral, soft-tissue neoplasm commonly found on the buccal mucosa.
  • In this report, we review clinical and histomorphologic data of 164 cases of oral lipomas retrieved from the files of Long Island Jewish Medical Center, Department of Dental Medicine (New Hyde Park, NY).
  • A review of oral lipoma with particular reference to the spindle cell variant is also presented.
  • [MeSH-major] Lipoma / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology

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  • (PMID = 11510003.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Torres-Domingo S, Bagan JV, Jiménez Y, Poveda R, Murillo J, Díaz JM, Sanchis JM, Gavaldá C, Carbonell E: Benign tumors of the oral mucosa: a study of 300 patients. Med Oral Patol Oral Cir Bucal; 2008 Mar;13(3):E161-6
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  • [Title] Benign tumors of the oral mucosa: a study of 300 patients.
  • OBJECTIVES: To analyze the frequency and type of the most common benign tumors of the oral mucosa found at the Hospital Stomatology Service, and to study the clinical characteristics and possible etiological factors.
  • MATERIAL AND METHODS: This is a retrospective study of 300 patients with histologically diagnosed benign tumors of the oral mucosa.
  • Data was compiled for each case, documenting information relating to age, gender, medication, habits (smoking, oral hygiene), anamnesis (reason for consultation, symptomatology, evolution), and the characteristics of the lesion (site, color, size, surface, consistency, and base).
  • RESULTS: Of all the tumors studied, 53% were histologically diagnosed as fibroma.
  • In the study of prevalence of benign tumors of the oral mucosa, no differences were found for age; however there were differences according to gender, finding a greater prevalence of fibromas, pyogenic granulomas, and giant cell granulomas in women, at a ratio of 2:1.
  • The group of tumors studied showed a significantly asymptomatic behaviour, and self-limiting and slow growth.
  • With respect to the possible etiologic agents, we found no statistically significant differences between them.
  • CONCLUSIONS: Following the study of 300 patients histologically diagnosed with benign tumor of the oral mucosa, we can state that with regard to prevalence, we found significant differences with respect to gender, being more frequent in women.
  • The fibroma is the most frequent benign tumor of the oral cavity.
  • [MeSH-major] Mouth Mucosa. Mouth Neoplasms

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  • (PMID = 18305435.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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6. Saran R, Tiwari RK, Reddy PP, Ahuja YR: Risk assessment of oral cancer in patients with pre-cancerous states of the oral cavity using micronucleus test and challenge assay. Oral Oncol; 2008 Apr;44(4):354-60
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  • [Title] Risk assessment of oral cancer in patients with pre-cancerous states of the oral cavity using micronucleus test and challenge assay.
  • Oral cancer is a common malignancy, ranking first among all cancers in Western and Asian countries.
  • Oral cancer is preceded by some benign lesions or conditions, which are termed pre-cancerous.
  • [MeSH-major] Mouth Neoplasms / genetics. Precancerous Conditions / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Chromosome Aberrations. Comet Assay / methods. DNA Damage. DNA Repair. DNA, Neoplasm / genetics. Disease Progression. Female. Humans. Leukocytes / drug effects. Leukocytes / pathology. Male. Methylnitronitrosoguanidine / pharmacology. Micronucleus Tests / methods. Middle Aged. Mouth Mucosa / pathology. Risk Assessment / methods

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  • [CommentIn] Oral Oncol. 2008 Jul;44(7):716-7 [18381248.001]
  • (PMID = 17936677.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 12H3O2UGSF / Methylnitronitrosoguanidine
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