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1. Santos RR, Damasceno RW, de Pontes FS, Cursino SR, Nishiwaki-Dantas MC, Vital Filho J, Dantas PE: Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings. Arq Bras Oftalmol; 2010 Jan-Feb;73(1):33-9
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  • [Title] Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings.
  • PURPOSE: To describe and analyze the features of a cases series of patients with primary epithelial neoplasms of the lacrimal gland, its surgical treatment, and histopathological findings.
  • METHODS: Retrospective evaluation of files from patients with primary epithelial neoplasms of the lacrimal gland in the period from 1997 to 2007.
  • All patients with primary epithelial tumors of the lacrimal gland were included in this study.
  • RESULTS: During the study period, there were 12 patients, 5 (41.7%) with benign tumors, all pleomorphic adenomas (benign mixed tumor) and 7 (58.3%) with malignant neoplasms, thus distributed: four cases of adenoid cystic carcinoma, two of mucoepidermoid carcinoma and one carcinoma expleomorphic adenoma.
  • Globally, patients mean age was 54.1 years-old (ranging from 14 to 70 years-old), with mean age of 52.4 years-old (ranging from 14 to 65 years-old) for benign neoplasms, and 55.3 years-old for malignant neoplasms (ranging from 26 to 70 years-old).
  • CONCLUSIONS: The most frequent primary epithelial neoplasms of the lacrimal gland were pleomorphic adenoma and adenoid cystic carcinoma during the study period.
  • Malignant tumors were more frequent than benign tumors.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Lacrimal Apparatus / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 20464111.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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2. Miyazaki T, Yamasaki T, Moritake K, Matsumoto Y, Akiyama Y, Nagai H, Yamamoto Y, Kodama T: Unusual progression of pleomorphic adenoma of the lacrimal gland: case report. Neurol Med Chir (Tokyo); 2005 Aug;45(8):407-10
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  • [Title] Unusual progression of pleomorphic adenoma of the lacrimal gland: case report.
  • The preoperative diagnosis was pleomorphic adenoma with or without malignant transformation, or cavernous angioma.
  • The transcranial route was chosen since tumor invasion to the cranial base was possible.
  • The histological diagnosis was pleomorphic adenoma.
  • The present case suggests that pleomorphic adenoma should also be considered in the differential diagnosis.
  • The therapeutic strategy for lacrimal gland tumors remains controversial, so a flexible management approach is required.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus / pathology. Lacrimal Apparatus Diseases / pathology. Orbital Neoplasms / pathology

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  • (PMID = 16127259.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Galatoire O, Hamédani M, Putterman M, Berges O, Morax S: [Adenocarcinoma in a pleomorphic adenoma of the lacrimal gland: a case study]. J Fr Ophtalmol; 2005 Oct;28(8):896-901
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  • [Title] [Adenocarcinoma in a pleomorphic adenoma of the lacrimal gland: a case study].
  • [Transliterated title] Adénocarcinome au sein d'un adénome pléomorphe de la glande lacrymale. A propos d'un cas.
  • PURPOSE: To report a patient with an adenocarcinoma in a pleomorphic adenoma of the lacrimal gland.
  • Adenocarcinoma constitutes a distinct group of epithelial malignancies of the lacrimal gland.
  • RESULTS: A 56-year-old man presented with a 3-month history of a lacrimal fossa mass.
  • The tumor was localized to the lacrimal gland.
  • Radiological investigations showed a round, well-defined lesion in the fossa of the lacrimal gland.
  • The final specimen showed an adenocarcinoma in a pleomorphic adenoma.
  • CONCLUSION: Although adenocarcinoma has rarely been reported in association with a pleomorphic adenoma of the lacrimal gland, this combination can exist.
  • If the malignant tumor is limited in the pleomorphic adenoma, the prognosis appears to be better than in cases of local extension.
  • [MeSH-major] Adenocarcinoma. Adenoma, Pleomorphic. Eye Neoplasms. Lacrimal Apparatus. Neoplasms, Multiple Primary

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  • (PMID = 16249774.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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4. Ahn JY, Chang JH, Kim SH, Lee KS: Pleomorphic adenocarcinoma of the lacrimal gland with multiple intracranial and spinal metastases. World J Surg Oncol; 2007;5:29
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  • [Title] Pleomorphic adenocarcinoma of the lacrimal gland with multiple intracranial and spinal metastases.
  • BACKGROUND: Pleomorphic adenoma of the lacrimal gland is known to undergo malignant transformation when incompletely excised.
  • CASE PRESENTATION: A 50-year-old woman presented with malignant transformation associated with both intracranial invasion and multiple intracranial and spinal disseminations in the third recurrence of pleomorphic adenoma of the lacrimal gland, 6 years after initial treatment.
  • CONCLUSION: It is important to recognize that leptomeningeal intracranial and spinal disseminations of pleomorphic adenocarcinoma can occur, although it is extremely rare.
  • To our knowledge, we report the first case of pleomorphic adenocarcinoma of the lacrimal gland presumably metastasizing to the intracranium and spine.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery

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  • (PMID = 17341319.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1820784
  • [General-notes] NLM/ Original DateCompleted: 20070810
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5. Hadjistilianou T, de Francesco S, Signori C, Menicacci F, Galluzzi P, Toti P: Pleomorphic adenoma of the lacrimal gland in an 18-year-old girl irradiated for bilateral retinoblastoma. Orbit; 2006 Mar;25(1):51-3
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  • [Title] Pleomorphic adenoma of the lacrimal gland in an 18-year-old girl irradiated for bilateral retinoblastoma.
  • PURPOSE: To report a case of pleomorphic adenoma of the lacrimal gland following irradiation for bilateral retinoblastoma.
  • RESULTS: Pleomorphic adenoma is rare in children and teenagers; it usually presents as a painless, slow growing mass in healthy adults.
  • In this case, it developed as a second primary tumor after irradiation for retinoblastoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus / pathology. Neoplasms, Radiation-Induced / pathology. Retinal Neoplasms / radiotherapy. Retinoblastoma / radiotherapy. Retinoblastoma / secondary

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  • (PMID = 16527777.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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6. Vagefi MR, Hong JE, Zwick OM, Bedrossian EH Jr, Seiff SR, Cockerham KP: Atypical presentations of pleomorphic adenoma of the lacrimal gland. Ophthal Plast Reconstr Surg; 2007 Jul-Aug;23(4):272-4
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  • [Title] Atypical presentations of pleomorphic adenoma of the lacrimal gland.
  • PURPOSE: To report 3 cases of pleomorphic adenoma of the lacrimal gland with atypical features.
  • METHODS: The medical records, radiographic imaging, operative reports, and tumor histopathology of 3 patients with unusual presentations of pleomorphic adenoma of the lacrimal gland were reviewed.
  • Histopathologic evaluation of all specimens with light microscopy was consistent with pleomorphic adenoma of the lacrimal gland.
  • CONCLUSIONS: Pleomorphic adenoma is the most common epithelial tumor of the lacrimal gland.
  • Pleomorphic adenoma may present abruptly with orbital inflammation mimicking orbital cellulitis, as a painful subcutaneous nodule, or demonstrate calcification with bony erosion on orbital imaging.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 17667095.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Chen CL, Chen CH, Tai MC, Lu DW, Cheng MF, Li WH: Pleomorphic adenoma of the lacrimal gland in a nine-year-old child. Clin Exp Ophthalmol; 2005 Dec;33(6):639-41
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  • [Title] Pleomorphic adenoma of the lacrimal gland in a nine-year-old child.
  • A case of a 9-year-old child with pleomorphic adenoma of the lacrimal gland is described.
  • Because of its age distribution, pleomorphic adenoma of the lacrimal gland is usually overlooked as a possible cause of unilateral proptosis in children.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 16402959.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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8. Ostrosky A, Klurfan FJ, Gonzalez MJ, Camaly D, Villa D: Pleomorphic adenoma of the lacrimal gland. Case report. Med Oral Patol Oral Cir Bucal; 2005 Jan-Feb;10(1):88-9; 86-8
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  • [Title] Pleomorphic adenoma of the lacrimal gland. Case report.
  • Lacrimal gland tumors are rare.
  • We present a case of a 69 year old male patient with a one year history of an orbital tumor (Pleomorphic Adenoma).
  • The tumor was surgically enucleated and patient recovery was very satisfactory, with no signs of recurrence after one year of follow-up.
  • [MeSH-major] Adenoma, Pleomorphic. Eye Neoplasms. Lacrimal Apparatus

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  • (PMID = 15627912.001).
  • [ISSN] 1698-4447
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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9. Lai T, Prabhakaran VC, Malhotra R, Selva D: Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy? Eye (Lond); 2009 Jan;23(1):2-6
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  • [Title] Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy?
  • AIM: To review the literature on biopsy of lacrimal gland pleomorphic adenoma (LGPA) and to examine the validity of the prohibition against biopsy in LGPA.
  • On the basis of a detailed examination of the literature on biopsy of both LGPA and pleomorphic adenoma of the salivary glands, it appears that there is no clear evidence to support the claim that biopsy increases the risk of recurrence or of malignant transformation of LGPA.
  • CONCLUSION: Lacrimal gland tumours are uncommon lesions and optimal management depends to a great extent on a definite preoperative diagnosis.
  • Preoperative biopsy should therefore be considered in all lacrimal gland mass lesions and management should be tailored to the biopsy findings.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Lacrimal Apparatus Diseases / pathology

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  • [CommentIn] Eye (Lond). 2010 Feb;24(2):386 [19407844.001]
  • (PMID = 18327162.001).
  • [ISSN] 1476-5454
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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10. Takahira M, Minato H, Takahashi M, Karino K, Sugiyama K: Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. Ophthal Plast Reconstr Surg; 2007 Sep-Oct;23(5):407-9
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  • [Title] Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland.
  • In a 48-year-old male patient, a well-circumscribed, round tumor in the lacrimal fossa was detected by CT.
  • During total excision of the tumor, a wall of the tumor ruptured, resulting in leakage of the fluid contents.
  • The wall of the tumor formed a cyst that contained residual yellowish fluid.
  • Histologically, the cyst wall included an adenocarcinomatous component and a focus of pleomorphic adenoma.
  • The tumor was diagnosed as a carcinoma ex pleomorphic adenoma of the lacrimal gland.
  • The carcinoma cells showed positive immunoreactivity for androgen receptor and BRST-2, indicating that the tumor was equivalent to a salivary duct carcinoma.
  • This case demonstrates that a carcinoma ex pleomorphic adenoma of the lacrimal gland may develop in a cyst.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 17881995.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Prabhakaran VC, Cannon PS, McNab A, Davis G, O'Donnell B, Dolman PJ, Ghabrial R, Selva D: Lesions mimicking lacrimal gland pleomorphic adenoma. Br J Ophthalmol; 2010 Nov;94(11):1509-12
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  • [Title] Lesions mimicking lacrimal gland pleomorphic adenoma.
  • AIM: To report a series of patients with lacrimal gland lesions simulating the clinicoradiological features of lacrimal gland pleomorphic adenoma (LGPA).
  • The diagnosis of LGPA was made in all cases by experienced orbital surgeons, based on clinicoradiological features, and lacrimal gland excision was performed.
  • Postoperative histology revealed lymphoma (four patients), chronic dacryoadenitis (three patients), adenoid cystic carcinoma (two patients), Sjogren's syndrome (two patients), cavernous haemangioma (one patient), benign lymphoid hyperplasia (one patient) and granulomatous dacryoadenitis (one patient).
  • Based on this study, the authors believe that fine-needle aspiration biopsy or intraoperative biopsy and frozen section diagnosis may help reduce unnecessary lacrimal gland excision.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis

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  • (PMID = 20962353.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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12. Li Y, Zhang TM, An YZ, Shi JT, Fu JD, Qiu E: [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae]. Zhonghua Yi Xue Za Zhi; 2006 Jun 20;86(23):1597-9
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  • [Title] [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae].
  • OBJECTIVE: To investigate the clinical manifestations of lacrimal gland tumor involving the anterior and middle cranial fossae and the effect of transcranial-orbital approach in treatment of such tumor.
  • METHODS: A retrospective study was conducted on the clinical data of 23 cases lacrimal gland tumor involving the anterior and middle cranial fossae confirmed by radiological examination, including 11 cases of adenoid cystic carcinoma, 6 cases of pleomorphic adenocarcinoma (malignant mixed tumor), 2 cases of adenocarcinoma, 1 case of squamous cell carcinoma, 1 case of ductal carcinoma, 1 case of mucoepidermoid carcinoma, and 1 case of benign mixed tumor, 15 males and 8 females, aged 42.5 (2 - 76), with a case history of 43 months (2 months to 27 years), with the chief complaints of progressive proptosis, disgenesia of the eye ball, and orbit pain, all undergoing transcranial-orbital operation from August 1998 to February. 2006.
  • Recurrence of tumor occurred in 4 cases, and 1 case died from distant metastasis of adenocarcinoma.
  • CONCLUSIONS: Malignant lacrimal gland tumors, mainly adenoid cystic carcinomas, incline to involve the anterior and middle cranial fossae.
  • Adequate orbital apex decompression and exposure of the tumor can result from suitable transcranial-orbital approach.
  • However, complete surgical excision is difficult, and the tumor has a tendency to recur post-operatively.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Skull Base Neoplasms / pathology

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  • (PMID = 16854296.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Ramlee N, Ramli N, Tajudin LS: Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion. Orbit; 2007 Jun;26(2):137-9
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  • [Title] Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion.
  • We reported a case of pleomorphic adenoma of the lacrimal gland involving the palpebral lobe in young teenage girl of Asian origin.
  • The benign tumor with its intact pseudocapsule was removed through lateral orbitotomy together with the suspicious looking orbital lobe.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis
  • [MeSH-minor] Adolescent. Chalazion / diagnosis. Diagnosis, Differential. Female. Humans. Lacrimal Apparatus. Tomography, X-Ray Computed

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  • (PMID = 17613864.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Orzechowska-Wylegała B, Jedrzejewski P, Wylegała E, Steplewska K: Recurrent benign pleomorphic adenoma of the lacrimal gland--a case report. Klin Oczna; 2008;110(7-9):301-3

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  • [Title] Recurrent benign pleomorphic adenoma of the lacrimal gland--a case report.
  • Benign pleomorphic adenoma (mixed tumor) is the most frequently occurring tumor of epithelial origin.
  • It occurs in serous glands, most frequently in parotid glands and rarely in small palatine glands, cheek glands, palatine tonsils and the lacrimal gland.
  • This study is a description of the therapeutic management of a patient with recurrent pleomorphic adenoma of the lacrimal gland.
  • In 1996, a 35 year old male patient underwent surgery to remove a tumor of the left orbit.
  • Histopathological examination revealed pleomorphic adenoma.
  • In 2005, from a cut along the upper-outer edge of the left orbit, an elastic and soft tumor 1 cm in diameter was removed from soft tissues of the upper eyelid.
  • An eyelid nodule of 0.8 mm in diameter was removed together with an elastic and hard tumor of size 2.5 x 1 cm.
  • The result of the histopathological examination of the palpebral tumor was pseudocystic tumor and of the orbital tumor was pleomorphic adenoma.
  • CONCLUSION: patients resected for pleomorphic adenoma of the lacrimal gland require a long period of postoperative observation and periodic ophthalmologic examination.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Lacrimal Apparatus / pathology. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery

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  • (PMID = 19112866.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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15. Currie ZI, Rose GE: Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol; 2007 Dec;125(12):1643-6
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  • [Title] Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland.
  • OBJECTIVE: To ascertain the need for follow-up after excision of pleomorphic adenoma of the lacrimal gland.
  • METHODS: Medical records were reviewed for 133 patients and only those patients with 5 years or more of follow up were classified into the following 5 subgroups: those with intact excision (group IA, n = 46), those with surgically intact excision but areas of complete attenuation of the pseudocapsule at histologic analysis (group IB, n = 7), those with previous inadvertent incisional biopsy (group IIA, n = 9), those with breach of the pseudocapsule during attempted intact excision (group IIB, n = 5), and those undergoing definitive surgery because of tumor recurrence after previous incomplete excision (group III, n = 5).
  • RESULTS: Seventy-two patients were followed up longer than 5 years; there were no known tumor recurrences among 61 patients excluded with shorter follow-up.
  • Patients in groups IA and IB exhibited no tumor recurrences at 8.2 to 34.1 years of follow-up.
  • A benign recurrence occurred along the superior orbital fissure in 1 patient in group IIA 12(1/2) years after the initial surgery and was resected.
  • CONCLUSIONS: Discharge would seem justified after intact excision of lacrimal gland pleomorphic adenoma, even when histologic examination shows extreme attenuation of the pseudocapsule.
  • Long-term follow-up is, however, necessary when there has been tumor disruption, either inadvertently during previous biopsy or by capsular breach during definitive excision.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 18071115.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Karcioglu ZA, Mascott CR: Computer-assisted image-guided orbit surgery. Eur J Ophthalmol; 2006 May-Jun;16(3):446-52
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  • All patients had tumor resection with the utilization of two frameless stereotactic systems: Cygnus and Stealth Station.
  • RESULTS: The applications of image-guided stereotactic surgery proved to be beneficial in three extensive orbital tumors, including optic nerve glioma, recurrent pleomorphic adenoma of lacrimal gland, and secondary orbital meningioma.
  • CONCLUSIONS: The interactive nature of image guidance can be useful in orbital surgery to orient the surgeon to the exact location within the surgical field and to determine the tumor margins.
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Adult. Aged. Child. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / pathology. Meningioma / surgery. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Optic Nerve Glioma / pathology. Optic Nerve Glioma / surgery. Tomography, X-Ray Computed

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  • (PMID = 16761248.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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17. Bernardini FP, Devoto MH, Croxatto JO: Epithelial tumors of the lacrimal gland: an update. Curr Opin Ophthalmol; 2008 Sep;19(5):409-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial tumors of the lacrimal gland: an update.
  • PURPOSE OF REVIEW: The goal of this article is to offer an update on the treatment and prognosis of the most common epithelial tumors of the lacrimal gland, report on new pathological entities and offer a review of the classification of lacrimal gland tumors.
  • RECENT FINDINGS: Improvements have been made in the understanding of lacrimal gland lesions with the knowledge that lacrimal gland tumors compare to the more common counterparts of the major salivary glands.
  • Therefore, the WHO's classification of salivary gland tumors has been adapted to the lacrimal gland pathology.
  • Until recently, primary adenocarcinomas of the lacrimal gland were not further subclassified, but they can now be divided into low-grade and high-grade malignancies.
  • Another important step forward has been taken on carcinoma ex pleomorphic adenoma of the lacrimal gland, which is subclassified into noninvasive carcinoma, with an excellent prognosis after complete excision and invasive carcinoma for which the prognosis is still guarded despite adjunctive radiotherapy.
  • SUMMARY: This article offers an update on diagnosis, classification and treatment of common and rare epithelial lacrimal gland tumors.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 18772674.001).
  • [ISSN] 1531-7021
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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18. Rizvi SA, Gupta Y, Gupta M: Surgical treatment and histopathological analysis of proptosis. Nepal J Ophthalmol; 2010 Jan-Jun;2(1):31-4
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  • The most common benign adult tumor found in our study was pleomorphic adenoma of the lacrimal gland {3 (20%)}.

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  • (PMID = 21141324.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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19. Ishida M, Hotta M, Kushima R, Tsuruoka S, Ohji M, Okabe H: Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Rinsho Byori; 2009 Aug;57(8):746-51
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  • [Title] Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • Ductal adenocarcinoma of the lacrimal gland is extremely rare; to our knowledge, only seven de novo cases and one case of ductal adenocarcinoma ex pleomorphic adenoma have been reported in the literature.
  • Here, we report a case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • A 70-year-old Japanese female received the resection of the recurrent lacrimal gland tumor (second surgery), under the clinical diagnosis of recurrent pleomorphic adenoma, fifteen years after the initial surgical resection.
  • The resected tumor was composed of recurrent pleomorphic adenoma and adenocarcinoma.
  • Adenocarcinoma component showed infiltrative papillo-tubular or microcystic growth of carcinoma cells, which had pleomorphic large nuclei with prominent nucleoli and rich eosinophilic cytoplasm.
  • Accordingly, the diagnosis of ductal adenocarcinoma ex pleomorphic adenoma was made.
  • The tumor recurred locally eight months after the second surgery, and tumor exenteration was performed(third surgery).
  • In the previously reported eight cases and the present case of lacrimal ductal adenocarcinomas, recurrence took place in 5 cases and two patients died from multiple metastases.
  • These data suggests that lacrimal ductal adenocarcinoma appears to have a poor prognosis, similar to salivary duct carcinoma, which is one of the most aggressive salivary carcinoma.
  • And further study is needed to clarify the clinicopathological features of the lacrimal ductal adenocarcinoma.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Eye Neoplasms / diagnosis. Eye Neoplasms / pathology. Lacrimal Apparatus. Neoplasms, Multiple Primary

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  • (PMID = 19764409.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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20. Mensink HW, Mooy C, Paridaens D: In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Clin Exp Ophthalmol; 2005 Dec;33(6):669-71
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  • [Title] In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • A case of an in situ adenocarcinoma of the lacrimal gland that developed in a recurring pleomorphic adenoma is presented.
  • Six years after incomplete resection of a pleomorphic adenoma, the patient complained of a progressive swelling of her right upper eyelid without pain or diplopia.
  • An orbital computerized tomography scan showed an inhomogeneous mass in the right lacrimal gland region without bone involvement.
  • After local excision of the in situ adenocarcinoma ex pleomorphic adenoma, the tumour has been in control for over 6 years.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 16402969.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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21. Chang CJ, Lin TK, Wei LC, Wen MC, Tsai HY, Wang JC, Tai MC: Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. Ann Ophthalmol (Skokie); 2006;38(2):141-4
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  • [Title] Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report.
  • Carcinoma ex pleomorphic adenoma affects glandular structures, occurring mostly in major salivary glands and less commonly in the lacrimal gland.
  • We present a rare case in the lacrimal gland.
  • We highlight the importance of keeping this rare tumor in mind and the early detection of symptoms because such a malignant transformation could occur in pleomorphic adenomas, with the proportion dependent on the duration of the tumor.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis

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  • (PMID = 17416946.001).
  • [ISSN] 1558-9951
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Ceylan A, Celenk F, Poyraz A, Uslu S: Pleomorphic adenoma of the nasal columella. Pathol Res Pract; 2008;204(4):273-6
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  • [Title] Pleomorphic adenoma of the nasal columella.
  • Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands.
  • It is much less common in the minor salivary glands, and rarely occurs at other sites, such as larynx, pharynx, trachea, lacrimal gland, and sinonasal tract.
  • We describe a very rare case of recurrent pleomorphic adenoma originating from the columella.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local. Neoplasm Seeding. Nose Neoplasms / pathology

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  • (PMID = 18295980.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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23. Kopp ED, Sahlin S, Tani E, Skoog L, Seregard S: Fine-needle aspiration biopsy in lacrimal gland pleomorphic adenoma. Eye (Lond); 2010 Feb;24(2):386
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration biopsy in lacrimal gland pleomorphic adenoma.
  • [MeSH-major] Adenoma / pathology. Biopsy, Needle / methods. Eye Neoplasms / pathology. Lacrimal Apparatus / pathology

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  • [CommentOn] Eye (Lond). 2009 Jan;23(1):2-6 [18327162.001]
  • (PMID = 19407844.001).
  • [ISSN] 1476-5454
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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24. Sakuma T, Ohashi H, Yamamoto K, Kawano K: Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. Jpn J Ophthalmol; 2008 Jan-Feb;52(1):67-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 18369704.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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