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1. Gawkowska-Suwinska M, Fijałkowski M, Białas B, Szlag M, Kellas-Ślęczka S, Nowicka E, Behrendt K, Plewicki G, Smolska-Ciszewska B, Giglok M, Zajusz A, Owczarek G: Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy. J Contemp Brachytherapy; 2009 Dec;1(4):211-215
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  • A significant decline in prostate-specific antigen (PSA) level is seen in patients with hormone-responsive cancer.

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  • (PMID = 28050174.001).
  • [ISSN] 1689-832X
  • [Journal-full-title] Journal of contemporary brachytherapy
  • [ISO-abbreviation] J Contemp Brachytherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Keywords] NOTNLM ; prostate cancer / radiotherapy / recurrences / salvage brachytherapy
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2. Strasser AA, Cappella JN, Jepson C, Fishbein M, Tang KZ, Han E, Lerman C: Experimental evaluation of antitobacco PSAs: effects of message content and format on physiological and behavioral outcomes. Nicotine Tob Res; 2009 Mar;11(3):293-302
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  • [Title] Experimental evaluation of antitobacco PSAs: effects of message content and format on physiological and behavioral outcomes.
  • INTRODUCTION: Antitobacco media campaigns using public service announcements (PSAs) have shown promise in reducing smoking initiation and increasing intentions to quit.
  • Research on what makes an effective PSA has had mixed outcomes.
  • The present study tested the effects of specific message features in antitobacco PSAs, using theory-based physiological and self-report outcomes.
  • METHODS: PSAs were categorized as high or low in message sensation value (MSV) and strength of argument and presented to 200 current smokers in a 2 x 2 factorial design.
  • Physiological responses-specifically, heart rate, skin conductance, zygomaticus major, and corrugator supercilii-were assessed while participants viewed the PSAs.
  • Among those low in sensation seeking, low MSV PSAs elicited higher self-efficacy, whereas the reverse was true for high sensation seekers.
  • High MSV PSAs elicited higher negative beliefs in low sensation seekers.
  • DISCUSSION: The present study represents the first comprehensive theory-based experimental investigation of the effects of different features of antitobacco PSAs and provides a framework for future research in identifying effective features of such PSAs.
  • Results illustrate the importance of considering individual differences, characterizing both PSA content and format, and outcome and response measures when evaluating antitobacco PSAs.

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  • (PMID = 19246628.001).
  • [ISSN] 1469-994X
  • [Journal-full-title] Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • [ISO-abbreviation] Nicotine Tob. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095856; None / None / / P50 CA095856-05; United States / NCI NIH HHS / CA / CA101404; United States / NCI NIH HHS / CA / P50 CA095856-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2666374
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3. Riedinger JM, Eche N, Fulla Y, Thuillier F: [PSA kinetics after total prostatectomy]. Ann Biol Clin (Paris); 2009 Jan-Feb;67(1):39-46
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  • [Title] [PSA kinetics after total prostatectomy].
  • [Transliterated title] Cinétique du PSA après prostatectomie totale.
  • The prostate specific antigen (PSA) is the best marker of the prostate cancer today although not very specific of this pathology.
  • With the lack of residual cancer, PSA becomes undetectable by the first month after total prostatectomy: less than 0.1 microg/L.
  • Faced with residual cancer, PSA either does not become undetectable or increases after an initial undetectable period.
  • A recurrence is defined by a value of PSA higher than 0.2 microg/L and confirmed on two successive assays.
  • The time of appearance of the recurrence and the PSA doubling time after total prostatectomy have, with the initial clinical stage and the Gleason score, a diagnostic value on the nature of the site of recurrence, local or metastatic.
  • [MeSH-minor] Biomarkers, Tumor / blood. Follow-Up Studies. Humans. Male. Neoplasm Staging. Time Factors

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  • (PMID = 19189884.001).
  • [ISSN] 0003-3898
  • [Journal-full-title] Annales de biologie clinique
  • [ISO-abbreviation] Ann. Biol. Clin. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Number-of-references] 67
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4. Treatment for hair loss affects prostate specific antigen. Nurs Stand; 2007 Mar 07;21(26):17

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  • : The recommendation for the adjustment of serum prostate-specific antigen (PSA) concentration for screening in men taking 5mg/day finasteride for benign prostatic hyperplasia should also apply to men taking 1mg/day for male pattern hair loss.

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  • (PMID = 27967427.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. van Hooft IM, Zeebregts CJ, van Sterkenburg SM, de Vries WR, Reijnen MM: The persistent sciatic artery. Eur J Vasc Endovasc Surg; 2009 May;37(5):585-91
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  • [Title] The persistent sciatic artery.
  • BACKGROUND: A persistent sciatic artery (PSA) is a rare vascular anomaly with an estimated incidence of 0.03-0.06%.
  • During early embryonic development, the sciatic artery usually disappears when the superficial femoral artery has developed properly.
  • This study aimed to assess the clinical presentation and outcome of a PSA.
  • METHOD: A systematic review of all cases of PSA published between 1964 and 2007 was performed.
  • RESULTS: In this review, 159 PSAs were described in 122 patients.
  • The mean age at which the PSA was discovered was 57 years, and the incidence was equally distributed with regards to gender.
  • The majority of PSAs was unilateral (70%) and of the complete type (79%).
  • An aneurysm was found in 48%, a stenosis in 7%, an occlusion of the PSA in 9% and an occlusion of an artery distal to the PSA in 6% of the subjects.
  • The treatment depended on the symptoms and classification of the PSA.
  • CONCLUSION: The PSA is a rare anomaly with a high incidence of complications including aneurysm formation and ischaemia that may lead to amputation.
  • [MeSH-minor] Angiography. Diagnosis, Differential. Global Health. Humans. Incidence. Prognosis. Stents. Ultrasonography, Doppler

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  • (PMID = 19231248.001).
  • [ISSN] 1532-2165
  • [Journal-full-title] European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
  • [ISO-abbreviation] Eur J Vasc Endovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 102
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6. Deslauriers V, Rouleau DM, Alami G, MacDermid JC: Translation of the Patient Scar Assessment Scale (PSAS) to French with cross-cultural adaptation, reliability evaluation and validation. Can J Surg; 2009 Dec;52(6):E259-63
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  • [Title] Translation of the Patient Scar Assessment Scale (PSAS) to French with cross-cultural adaptation, reliability evaluation and validation.
  • BACKGROUND: Patient esthetic satisfaction related to scarring after orthopedic surgery was rarely assessed before the development of the Patient Scar Assessment Scale (PSAS).
  • The purpose of our study was to translate and validate the PSAS and assess the psychometric properties of the French version.
  • First, 2 independent translators completed the forward translation of the PSAS and then met to achieve a consensus version.
  • We assessed the test-retest reliability of the new French scale, which was filled out twice by a cohort of 53 patients, using scale distribution analysis, internal consistency (Chronbach alpha) and absolute agreement (intraclass correlation coefficients [ICC (2,1)]).
  • The reliability of the translated version (PSAS-Fr) and its internal consistency was high (Chronback alpha 0.87-0.98 for each of the 6 questions), and the test-retest reliability was excellent (ICC 0.96).
  • CONCLUSION: The PSAS-Fr was successfully translated from the original English version and demonstrated strong cross-sectional psychometric properties.

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  • (PMID = 20011161.001).
  • [ISSN] 1488-2310
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] ENG
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2792396
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7. Riedinger JM, Eche N, Bachaud JM, Crehange G, Fulla Y, Thuillier F: [PSA kinetics after radiotherapy]. Ann Biol Clin (Paris); 2009 Jul-Aug;67(4):395-404
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  • [Title] [PSA kinetics after radiotherapy].
  • [Transliterated title] Cinétique de PSA après radiothérapie.
  • The prostate specific antigen (PSA) is the best marker of the prostate cancer today although not very specific of this pathology.
  • After radiotherapy, PSA can decrease after a mean interval of one to two years to a value less than 1 microg/L (predictive of recurrence-free survival).
  • Biochemical recurrence after radiotherapy is defined by an increase of PSA by 2 microg/L or more above the PSA nadir, whether or not it is associated with endocrine therapy.
  • The time of appearance of the recurrence and the PSA doubling time after total radiotherapy have a diagnostic value on the nature of the site of recurrence, local or metastatic.
  • [MeSH-minor] Aged. Follow-Up Studies. Half-Life. Humans. Kinetics. Male. Middle Aged. Neoplasm Metastasis. Time Factors

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  • (PMID = 19656762.001).
  • [ISSN] 0003-3898
  • [Journal-full-title] Annales de biologie clinique
  • [ISO-abbreviation] Ann. Biol. Clin. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
  • [Number-of-references] 77
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8. Linebarger DL, Piotrowski JT: Evaluating the educational potential of health PSAs with preschoolers. Health Commun; 2008 Nov;23(6):516-25
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  • [Title] Evaluating the educational potential of health PSAs with preschoolers.
  • Children learn from a variety of televised programs, including the short public service announcements (PSAs) that air between children's programs.
  • PSAs are designed to repetitively expose children to important content ranging from the benefits of reading to health-related messages.
  • The purpose of this study was to evaluate 5 PSAs containing health messages for preschoolers (i.e., nutrition, physical activity, and hand washing).
  • Child PSA viewers were able to recall more of the educational content, apply this knowledge to specific choices contained in each message, and transfer this knowledge to novel situations compared with their nonviewing counterparts.

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  • (PMID = 19089699.001).
  • [ISSN] 1532-7027
  • [Journal-full-title] Health communication
  • [ISO-abbreviation] Health Commun
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Nan X, Zhao X: The influence of liking for antismoking PSAs on adolescents' smoking-related behavioral intentions. Health Commun; 2010 Jul;25(5):459-69
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  • [Title] The influence of liking for antismoking PSAs on adolescents' smoking-related behavioral intentions.
  • In this research, we examine the influence of liking for antismoking public service announcements (PSAs), relative to that of PSAs' perceived argument strength, on adolescents' smoking-related behavioral intentions.
  • Data from the first Legacy Media Tracking Survey (LMTS-I) suggest that the relative persuasive impact of PSA liking and perceived argument strength varies as a function of message recipients' smoking status.
  • PSA liking appears to be an important predictor of smoking intentions for never smokers, whereas perceived argument strength strongly predicts quitting intentions for current smokers.
  • For former smokers, both perceived argument strength and PSA liking have significant effects on smoking intentions, with perceived argument strength exerting a stronger impact.


10. Cepeda Piorno J, Rivas del Fresno M, Fuente Martín E, González García E, Muruamendiaraz Fernández V, Fernández Rodríguez E: [Advantages and risks of the use of prostate-specific antigen (PSA) in the health-care area No. 4 of Gijon (Asturias)]. Arch Esp Urol; 2005 Jun;58(5):403-11
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  • [Title] [Advantages and risks of the use of prostate-specific antigen (PSA) in the health-care area No. 4 of Gijon (Asturias)].
  • [Transliterated title] Ventajas y riesgos de la utilización del antígeno prostático específico (PSA) en el area sanitaria v de Gijón (Asturias).
  • OBJECTIVES: The diagnosis of prostate cancer has changed significantly with the introduction of PSA in the clinical practice.
  • Despite screening is under controversy the use of PSA has become widespread.
  • The objective of this paper is to know the use of PSA in our health-care area and to analyze perceived risks and benefits.
  • METHODS: From the informatic archives we analyze PSA determinations performed in our health-care area (290.956 citizens) over 2000 and 2001.
  • RESULTS: 25.519 PSA determinations were performed.
  • PSA was normal in 78.7% of the patients and higher than 4 ng/ml in 21.2%.
  • Depending on the first PSA, diagnosis was started by a GP in 44% of the cases, a urologist in 46%, and the remaining 10% by other specialists.
  • Mean time from first PSA to diagnosis was 5 months, without significant differences between GPs and specialities .
  • The use of PSA by GPs is variable (between 8.1 and 45.8 determinations per 100 men over 50 years), without significant differences in prostate cancer detection by number of PSAs or differences in age.
  • There is a greater incidence and increase of cancer in the rural area (from 33.52 to 221.1 new cases/ 100.000 inhabitants/year).
  • CONCLUSIONS: We confirm the general use of this test and the trend to screening in the primary health-care level, which participates in an important manner in the diagnosis.
  • PSA brings forward the diagnosis of prostate cancer 5 years in our area, and shoots its incidence rates.
  • The high use of such marker in our population of advanced age may be considered inadequate.
  • [MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / blood. Mass Screening / statistics & numerical data. Neoplasm Proteins / blood. Prostate-Specific Antigen / blood. Prostatic Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Early Diagnosis. Humans. Incidence. Male. Middle Aged. Predictive Value of Tests. Primary Health Care / statistics & numerical data. Prostate / pathology. Referral and Consultation / statistics & numerical data. Retrospective Studies. Risk. Sensitivity and Specificity. Spain / epidemiology. Urology / statistics & numerical data

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  • (PMID = 16078781.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.4.21.77 / Prostate-Specific Antigen
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11. Börgermann C, Loertzer H, Luboldt HJ, Hammerer P, Fornara P, Graefen M, Rübben H: [PSA--Quo vadis?]. Urologe A; 2009 Sep;48(9):1008, 1010, 1012-4, passim
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  • [Title] [PSA--Quo vadis?].
  • [Transliterated title] PSA--Quo vadis?
  • Digital rectal examination is supplemented by determination of prostate-specific antigen (PSA).
  • Before the first PSA test, the patient must be informed of possible consequences such as biopsy recommendation and treatment options.
  • [MeSH-major] Ambulatory Care / methods. Biomarkers, Tumor / blood. Prostate-Specific Antigen / blood. Prostatic Neoplasms / blood. Prostatic Neoplasms / diagnosis

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  • (PMID = 19680620.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Number-of-references] 61
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12. Ponholzer A, Stoiber F, Loidl W, Rauchenwald M, Schramek P, Madersbacher S: [How to use PSA in 2009]. Wien Med Wochenschr; 2009;159(21-22):515-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [How to use PSA in 2009].
  • [Transliterated title] Aktueller Einsatz von PSA.
  • PSA is without any doubt the most frequently used marker in urology due to its helpful information regarding various aspects of diagnosis, therapy and prognosis in men with prostate cancer.
  • On the other hand, many controversies still exist about the various indications for PSA-determination.
  • The following overview is aimed to analyse the current status of PSA in the management of men undergoing screening, therapy or follow-up of prostate cancer.
  • Anyhow, a detailed knowledge of how to use and interpret PSA and PSA-kinetics is considered to play a crucial role in prostate cancer patients.
  • Current strategies are aimed to start and stop PSA-use earlier.
  • [MeSH-major] Biomarkers, Tumor / blood. Prostate-Specific Antigen / blood. Prostatic Neoplasms / blood. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Algorithms. Biopsy. Early Diagnosis. Humans. Male. Mass Screening. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Prostate / pathology. Survival Rate

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  • (PMID = 19997836.001).
  • [ISSN] 1563-258X
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Number-of-references] 25
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13. Rybikowski S, Maurin C, Deturmeny J, Delaporte V, Lechevallier E, Coulange C: [PSA and spironolactone]. Prog Urol; 2010 Feb;20(2):154-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [PSA and spironolactone].
  • [Transliterated title] PSA et spironolactone.
  • We report the case of a 72-year-old man having a cancer of prostate which normalized its PSA after institution of a treatment by spironolactone for ascites.
  • [MeSH-minor] Aged. Androgen Antagonists / therapeutic use. Humans. Male. Neoplasm Recurrence, Local / drug therapy. Prostate-Specific Antigen / blood

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  • [Copyright] (c) 2009. Published by Elsevier Masson SAS.
  • (PMID = 20142058.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Androgen Antagonists; 27O7W4T232 / Spironolactone; EC 3.4.21.77 / Prostate-Specific Antigen
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14. Benchikh El Fegoun A, Villers A: [Molecular forms of PSA]. Prog Urol; 2007 Apr;17(2):165-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Molecular forms of PSA].
  • [Transliterated title] Les formes moléculaires du PSA.
  • Molecular forms of serum PSA (prostate specific antigen) have been developped to improve total PSA sensitivity and specificity in prostate cancer diagnosis and staging.
  • Total PSA is measured in bound (complexed PSA) and unbound (free PSA) molecular forms.
  • Their levels in absolute values and in relation to total PSA (f/t PSA and c/t PSA) have been evaluated.
  • The percentage of free PSA is more specific but less sensitive than tPSA and it is not recommended as a first line diagnostic test.
  • Molecular derivates of free PSA have been identified: proPSA (precursor inactive form of PSA), intact PSA (an additionnal form of proPSA that is found intact and inactive), human Kallikrein 2 and BPSA (for benign PSA wich is associated to BPH) have been evaluated.
  • [MeSH-minor] Humans. Male. Neoplasm Staging. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / pathology. Protein Precursors / classification. Sensitivity and Specificity. Tissue Kallikreins / classification

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  • (PMID = 17489311.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Protein Precursors; EC 3.4.21.35 / Tissue Kallikreins; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Number-of-references] 38
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15. Abedi M, Ma Q, Bais A, Gomes E, Beaudoin E, Lu L, Davol P, Cohen SI, Junghans R: Phase I trial of anti-PSMA designer T-cell autografting in prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e16132

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Outcomes will include Phase Ia goals of safety and toxicity and Phase Ib goals of establishing an optimal biologic dose in terms of designer T cell engraftment and tumor response.
  • The patients had PSA reductions of 50 and 70% in the two months following treatment.
  • Results with additional patients will be described in terms of safety, engraftment efficiency and tumor responses.

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  • (PMID = 27963366.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Obeidat NA, Mullins CD, Onukwugha E, Seal B, Hussain A: Characteristics of elderly metastatic prostate cancer (M1 PC) long-term survivors in the SEER Medicare database receiving androgen-deprivation therapy (ADT). J Clin Oncol; 2009 May 20;27(15_suppl):e17513

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This population-based analysis evaluated if long-term survivors (LT) receiving ADT possessed different characteristics relative to short-term survivors (ST).
  • Within this 66y+ population, LT pts were younger (p < 0.0001), more likely to be married (p = 0.0277), and were comprised of lower % of non-Hispanic white pts and higher % of 'other' races, but comparable % of African American and White-Hispanics (p = 0.0005).
  • Distributional differences in PSA were detected, but interpreting the results was difficult due to missing or unknown information.

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  • (PMID = 27963274.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Small E, Harzstark A, Weinberg VK, Smith DC, Mathew P, Beer T, Liu G, Sharib J, Rosenberg J: Ixabepilone, mitoxantrone, and prednisone in patients with metastatic castration-resistant prostate cancer refractory to docetaxel-based therapy: A phase II study of the DOD Prostate Cancer Clinical Trials Consortium. J Clin Oncol; 2009 May 20;27(15_suppl):5058

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of 37 patients currently evaluable for response, 14 (38%; 95% CI: 22-55%) have had a confirmed ≥50% decline in PSA and 19 (51%; 95% CI 34-68%) have had a confirmed ≥30% decline in PSA.

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  • (PMID = 27962970.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Wu Y, Kwok Y, Mirmiran A, Goloubeva O, Mannuel H, Dawson N, Amin P, Hussain A: Weekly paclitaxel (P) with concurrent external beam radiation (EBRT) and androgen deprivation therapy (ADT) in high-risk prostate cancer (PC) patients with or without prior prostatectomy (RP). J Clin Oncol; 2009 May 20;27(15_suppl):5122

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: For pts undergoing RP, high risk was defined as: pT3 and/or pN+, M0, and/or rising PSA (> 0.5) post RP.
  • For pts not undergoing RP (i.e. locally advanced PC [LAPC]) high risk included: cT2b-4N0, N+, M0; bGS 8-10; bGS ≥ 7 + PSA ≥ 10 but ≤ 150; and/or PSA ≥ 20 but ≤ 150.
  • RESULTS: Between October 1999 and December 2006, 59 pts (29 W, 28 AA) were enrolled (n = 29 LAPC, n = 30 RP); median age 67 yrs, median PSA at trial entry 5.9 (27.5 LAPC, 1.6 RP), median GS 8.

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  • (PMID = 27964408.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Gillison TL, Appleman LJ, Friedland DM, Evans TL, Lara PN, Gooding WE, Lenzner DE, Strausser HM, Gingrich JR, Chatta GS: Docetaxel and imatinib every 21 days for castration resistant prostate cancer: A phase II trial. J Clin Oncol; 2009 May 20;27(15_suppl):e16086

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Imatinib (I), a tyrosine kinase inhibitor, modulates PDGFR-ß in tumor vasculature.
  • Secondary endpoints were rate of PSA response and overall survival (OS).
  • The sample size of 43 pts was designed to provide 90% power to detect an increase in TTP from 5 to 8 months.
  • 12 pts had PR (41.4%), 9 had SD (31.0%), and 8 had no response (27.6%) by PSA.
  • 23 (79%) pts had PSA progression, 3 pts died before progression, and 3 pts remain on trial.
  • For all evaluable pts who had PR or SD by PSA (N = 21), median TTP was 7.1 months (95% CL: 5.5, 9.1 months).
  • Toxicity precludes its use in the general population, although its role in select pts with good performance status needs to be explored.

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  • (PMID = 27963108.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Valdagni R, Marrari A, Squarcina P, Villa S, Filipazzi P, Salvioni R, Rancati T, Asioli M, Parmiani G, Rivoltini L: Vaccination with survivin and PSMA-derived peptides for controlling biochemical recurrence in prostate cancer: A pilot study. J Clin Oncol; 2009 May 20;27(15_suppl):e16042

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present preliminary results of pilot study using a multiple peptide-based anti-tumor vaccine.
  • METHODS: A phase I-II trial of vaccination (vax) with HLA-A*0201-restricted peptides from PSMA and Survivin was carried out in 20 pts with b-failure after surgery or radiotherapy (mean pre-vax PSA: 1.83 ng/ml).
  • Antigen (Ag) and tumor-specific T cell responses were extensively monitored in peripheral blood together with CD4+CD25+Foxp3+ Treg frequency.
  • PSA trend was also registered.
  • 6 pts had no biochemical response to vax and switched to hormonal therapy, while 14/20 exhibited a significant although transient PSA decrease during vax (11 in the priming phase and 3 in boosting).
  • However, the reduced ability of vax-induced Ag-specific CD8+ T cells to cross-recognize PCa cells, together with their low frequency in PBMC, could explain why PSA control was achieved only transiently and in strict dependence with vax administration.
  • Anti- tumor vax represent a useful tool for controlling PCa biochemical recurrence in the absence of major side effects, but immunization protocols inducing efficient tumor cell killing still need to be identified.

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  • (PMID = 27963024.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Talantov D, Jatkoe T, Bohm M, Zhang Y, Stricker P, Kattan MW, Sutherland RL, Kench JG, Wang Y, Henshall S: Gene-based prediction of PSA recurrence for clinically localized prostate cancer patients. J Clin Oncol; 2009 May 20;27(15_suppl):5132

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene-based prediction of PSA recurrence for clinically localized prostate cancer patients.
  • We combined an established nomogram and novel molecular predictors into a new prognostic model of prostate specific antigen (PSA) recurrence.
  • METHODS: Gene expression profiles from formalin-fixed, paraffin-embedded (FFPE) localized prostate cancer tissues were analysed to identify genes associated with PSA recurrence.
  • The RTPCR profiles from 3 of these genes, along with the output from the Kattan post-operative nomogram, were used to produce a predictive model of PSA recurrence.
  • RESULTS: After variable selection, a model of PSA recurrence was built that combined expression values of 3 genes and the postoperative nomogram.
  • The 3-gene plus nomogram model predicted 5-year PSA recurrence with a concordance index (c-index) of 0.77 in a validation set compared to a c-index of 0.67 for the nomogram.
  • CONCLUSIONS: This new gene-based classifier has superior predictive power when compared against the 5-year nomogram to assess risk of PSA recurrence in patients with organ-confined prostate cancer.

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  • (PMID = 27964430.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Undevia-Yedavalli N, Dandade N, Luu T, Samaras A, Sartor O, Nonzee N, Bennett C: Quality-of-life and LhRH agonist therapy among prostate cancer patients following PSA failure. J Clin Oncol; 2009 May 20;27(15_suppl):e16083

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality-of-life and LhRH agonist therapy among prostate cancer patients following PSA failure.
  • : e16083 Background: Growing numbers of prostate cancer patients experience biochemical relapse (PSA failure) after initial treatment.
  • LhRH agonist (hormonal) therapy can reduce PSA levels, but there is no clear evidence that it slows disease progression or reduces mortality.
  • We evaluated health related quality of life and treatment satisfaction among prostate cancer patients who experience PSA failure.
  • METHODS: Eligibility criteria were receipt of primary therapy for prostate cancer followed by a PSA nadir and subsequent PSA rise to at least 0.2 ng/ml.
  • CONCLUSIONS: Among patients with PSA Failure, the only health-related QOL difference is reflected in sexual activity related to erectile dysfunction, but not sexual satisfaction among patients who all have a high level of treatment decision satisfaction and sexual activity.

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  • (PMID = 27963104.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Reid AH, Attard G, Danila D, Ryan CJ, Thompson E, Kheoh T, Molina A, Small E, Scher H, De-Bono JS: A multicenter phase II study of abiraterone acetate (AA) in docetaxel pretreated castration-resistant prostate cancer (CRPC) patients (pts). J Clin Oncol; 2009 May 20;27(15_suppl):5047

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Total maximal PSA declines with AA at any point on study of ≥30%, ≥50%, and ≥ 90% were observed in 32 (69%), 24 (51%) and 7 (15%) pts respectively.
  • A similar trend in PSA response was seen at wk 12.
  • CONCLUSIONS: AA has anti-tumor activity in these heavily pretreated pts, as evidenced by sustained PSA declines, improvement in PS and RECIST responses.

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  • (PMID = 27962950.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Trock B, Han M, Humphreys EB, Partin AW, Eisenberger MA, Walsh PC: Survival following early hormone therapy for men with rapid PSA doubling time within 2 years following radical prostatectomy. J Clin Oncol; 2009 May 20;27(15_suppl):5065

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival following early hormone therapy for men with rapid PSA doubling time within 2 years following radical prostatectomy.
  • METHODS: Retrospective analysis of a cohort of 488 men undergoing RP at Johns Hopkins Hospital from 1982-2004, who experienced biochemical recurrence and received no salvage therapy (n = 386) or salvage hormonal therapy (n = 102); no one received adjuvant therapy.
  • After adjusting for PSA doubling time (PSADT), RP Gleason score, and year of surgery, hormonal therapy did not significantly improve OS for all men, compared to no salvage therapy: hazard ratio (HR) = 0.72 (95% confidence interval (CI): 0.45-1.17), p = 0.187.

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  • (PMID = 27964253.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Nabhan C, Tolzien K, Lestingi TM, Galvez A, Bitran JD: Effect of sorafenib on chemotherapy resistance and refractoriness in castration-resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):e16105

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In studies employing docetaxel (D), 35-39% of pts did not complete therapy due to progression and only 45-50% had a PSA response.
  • Median age was 68 (range 61-83), median PSA was 111.2 ng/ml (13.6-1703.9).
  • Median PSA-DT pre-study was 2 months (0.5-6) and median time from last chemotherapy to starting study was 4 weeks.
  • In all, 6 out of 14 pts (42%) had a PSA decline after adding sorafenib and 3 (21%) had stable PSA.
  • Of these 9 pts (PR+SD), 2 never doubled their PSA.
  • Two pts had PSA decline after withdrawing sorafenib.
  • Median TTP for PSA was 3.75 months.
  • PSA responses did not correlate with radiographic changes or clinical benefit.

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  • (PMID = 27963335.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Higano C, Alumkal J, Ryan CJ, Yu EY, Beer TM, Chandrawansa K, Katz T, Youssoufian H, Schwartz J, Prostate Cancer Clinical Trials Consortium: A phase II study evaluating the efficacy and safety of single agent IMC A12, a monoclonal antibody (MAb), against the insulin-like growth factor-1 receptor (IGF-IR), as monotherapy in patients with metastastic, asymptomatic castration-resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5142

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 9 of 31 pts experienced disease stabilization for ≥6 mos (range: 7.4-12.5 mos), 5 pts (3 with PSA reduction) continue on IMC-A12.
  • Pharmakinetic and pharmacodynamic analyses are pending.

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  • (PMID = 27964448.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Donovan MJ, Khan F, Powell D, Capodieci P, Gleave M, Taylor I, Gomez-Navarro J, Cordon-Cardo C: Characterization of lymphoid infiltrates in prostatectomy specimens post neoadjuvant hormonal therapy using quantitative immunofluorescence and RNA FISH. J Clin Oncol; 2009 May 20;27(15_suppl):e16104

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Using quantitative immunofluorescence (IF), image analysis and RNA FISH we examined a series of prostatectomy specimens from patients, ± neoadvjuvant hormonal therapy (NHT) and determined their baseline immune characteristics.
  • Sections were analyzed with three multiplex IF assays, triplicate images acquired with spectral imaging, digitally masked and processed with IF image analysis software.
  • Number of Treg (CD4+/CD25+/Foxp3+) cells were similar between groups; however, in NHT an increased Treg population was associated with an elevated preoperative PSA compared with controls (p<0.05).
  • IFNg transcript activity was low in the entire cohort and limited to tumor epithelial cells.

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  • (PMID = 27963334.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Gravis G, Walz J, Bagattini S, Esterni B, Mimoun C, Salem N, Marcy M, Brunelle S, Viens P, Bladou F: External validation of a nomogram predicting survival in men with metastatic hormone-refractory prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e16066

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At the time of inclusion, median age was 69.0 years, median PSA was 40ng/ml, 93% had known bone metastases and 19% had visceral metastases.
  • The area under the receiver operating characteristics curve was used to estimate the predictive accuracy of the nomogram and calibration plots were used for comparison between predicted and observed probabilities.

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  • (PMID = 27963062.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Winkfield KM, Chen M, Dosoretz DE, Salenius SA, Katin MJ, Ross R, D'Amico AV: Race and survival following brachytherapy-based treatment for men with localized or locally advanced adenocarcinoma of the prostate. J Clin Oncol; 2009 May 20;27(15_suppl):5068

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A Cox regression multivariable analysis was used to evaluate the risk of death in African-American (AA) and Hispanic (H) men as compared to Caucasian men adjusting for age, pretreatment PSA, Gleason score, clinical T stage, year and type of treatment, and comorbidity level.
  • As shown in the table , other factors significantly associated with an increased risk of death included age (p<0.001), PSA (p = 0.02), Gleason score 8 to 10 (p = 0.001), year of brachytherapy (p<0.001), and presence of 2 or more significant comorbidities (p = 0.003).

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  • (PMID = 27964249.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Ross RW, Bankaitis-Davis D, Siconolfi L, Katz L, Storm K, Magidson J, Wassmann K, Oh WK: Sensitivity and specificity of a whole-blood RNA transcript-based diagnostic test for the diagnosis of prostate cancer (CaP) compared with prostate-specific antigen (PSA) alone. J Clin Oncol; 2009 May 20;27(15_suppl):5052

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sensitivity and specificity of a whole-blood RNA transcript-based diagnostic test for the diagnosis of prostate cancer (CaP) compared with prostate-specific antigen (PSA) alone.
  • : 5052 Background: Screening for CaP with PSA testing is limited by a high number of false postives, particularly in the setting of benign prostatic hypertrophy (BPH).
  • The goal of this study was to develop whole blood RNA transcript-based diagnostic tests that improve the diagnosis of CaP over PSA alone.
  • METHODS: From August 2006 to October 2008, three prospective cohorts of men consented to the collection of whole blood in PAXgene Blood RNA tubes for gene expression analysis: men with newly diagnosed, localized, untreated CaP, otherwise healthy men without CaP, and otherwise healthy men with BPH.
  • Logistic regression methods were used to develop models to optimize prostate cancer diagnosis.
  • RESULTS: 182 men underwent expression analysis (n = 76, 76 and 30 for CaP, normal, and BPH cohorts, respectively).
  • Considering only the CaP and normal cohorts, PSA alone (using a cut-off of 4 ng/ml) had a specificity of 94.7%, but sensitivity of only 71.1% for diagnosis of CaP, or 90.8% and 77.6%, respectively, when using age-adjusted PSA criteria.
  • A model consisting of the expression analysis of 6 genes and PSA had a higher specificity (96.1%) and a much improved sensitivity (97.4%) for CaP diagnosis.
  • When the BPH cohort was added, the improvement of the 6-gene model remained (sensitivity and specificity of 97.4% and 92.0% vs 77.6% and 88.1% using the age-adjusted PSA criteria).
  • Further model development using the CaP and BPH cohorts yielded a 5-gene model which, integrated with PSA and age, correctly predicted 96.1% of the CaP pts and 93.3% of BPH pts.
  • Such a molecular CaP biomarker would be a powerful tool to reduce unnecessary biopsies in patients without CaP and detect CaP in patients with PSA values below the current cutoff.

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  • (PMID = 27962956.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Feyerabend S, Stefanovic S, Gouttefangeas C, Widenmeyer M, Wernet D, Hennenlotter J, Bedke J, Dietz K, Pascolo S, Rammensee H, Stenzl A: HLA-associated multipeptide vaccination in biochemically relapsed prostate cancer patients. J Clin Oncol; 2009 May 20;27(15_suppl):5134

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Study endpoints are side effects as well as PSA- and T-cell response.
  • METHODS: Patients (pts) with rising PSA after primary curative surgical treatment without metastatic imageable lesions receive 14 peptides emulsified in Montanide ISA51 subcutaneously, combined with one of four T-cell stimulatory adjuvants versus no adjuvant for 18 months (mo) or until progression.
  • PSA doubling time (DT) and clinical performance are monitored.
  • During the vaccination period, geometric mean PSA DT increased from 7.8 mo (range 1.5 - 44.8 mo, 25 pts) to 11.8 months (range 2.2 - 571.3 mo, 24pts) whereas 1 pt showed a decreasing PSA value.
  • Overall 8/25 pts (32%) had a mean rise of PSA DT of 81.6 mo and four of them did not receive any further treatment and were evaluable for follow-up (FU) after peptide vaccination (FU median 16 mo, range 5-33).
  • These four pts raised their mean geometric PSA DT from 8.2 mo prior study treatment to 51.9 mo at treatment end and 52.5 mo at end of FU.
  • PSA progressed unchanged in 10 patients (40%) or increased intermittently only in 4 pts.
  • Two pts had PSA decline or DT increase during FU but not during the treatment period.
  • All pts reacted to at least one of the tumor antigen-derived HLA-class I epitopes after the fourth vaccine injection and up to six peptides were recognized simultaneously by CD8+ T cells in some individuals.
  • CONCLUSIONS: Multi peptide vaccination stabilized or slowed down PSA progress in 11 of 25 cases.
  • Rise of PSA DT delaying standard treatment up to 33 mo and thus, delaying disease specific mortality is feasible.

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  • (PMID = 27964428.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. De Jager RL, Roman L, Lopatkin N, Karlov P, Breitz H, Earhart R: Results of a phase II study of picoplatin with docetaxel and prednisone in first-line treatment of castration-resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5140

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Previously, a PSA response rate of 25% was observed when Pico monotherapy was infused at 120 mg/m<sup>2</sup> Q3W (N = 20).
  • Picoplatin therapy was well-tolerated at a dose of 120 mg/m<sup>2</sup> and 19 of 32 evaluable pts (59%) achieved a confirmed PSA response.
  • PSA responses were defined as a reduction from baseline of at least 50% maintained for at least 4 weeks.
  • Tumor response was measured using RECIST.
  • Median baseline PSA was 340.8 ng/mL (range 5.6-3019).
  • One pt had no baseline PSA data.
  • Of the 24 patients with evaluable post-treatment PSA, 83% (95% CI 64-93%) had PSA decreases <50% of baseline, and in 8 of these (33% of the evaluable population), PSA reached normal levels (< 4 ng/mL).
  • In the intent-to-treat population, the PSA response rate was 63% (95% CI 45-77%).
  • CONCLUSIONS: Picoplatin was safely administered to patients with CRPC as 1<sup>st</sup>-line therapy at 120 mg/m<sup>2</sup> Q3W with full doses of docetaxel and prednisone, resulting in a PSA response rate of 83% of evaluable patients.

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  • (PMID = 27964433.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Medioni J, Deplanque G, Maurina T, Ferrero JM, Rodier JM, Raymond E, Allyon J, Kalla S, Dufour-Lamartinie JF, Oudard S: Dose finding and safety analysis of inecalcitol in combination with a docetaxel-prednisone regimen in hormone-refractory prostate cancer (HRPC) patients. J Clin Oncol; 2009 May 20;27(15_suppl):5151

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dose finding and safety analysis of inecalcitol in combination with a docetaxel-prednisone regimen in hormone-refractory prostate cancer (HRPC) patients.
  • Calcemia, creatininemia and CBC were assessed weekly; biochemistry, ECG and PSA every 3 weeks.
  • Efficacy endpoint was PSA response defined as ≥30% decline within 3 months.
  • RESULTS: Five dose levels: 40, 80, 160, 300, 600 μg have been evaluated in 34 pts; 9 pts are still being treated at 600 μg; 25 pts have completed 6 cycles (13 bone metastases; 3 extrasqueletic metastasis, 8 bone and extrasqueletic metastases; 1 PSA-only disease).
  • Median age was 72 years (range, 53-87), median Gleason score (Gs) 7 (36% Gs 10-8, 64% Gs 7-6) and median PSA 41.5 ng/mL (range, 0.9-962.4).
  • Of the 23 evaluable pts for PSA response, 20 (87%) had ≥30% PSA decline.
  • PSA responses with this combination are encouraging.

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  • (PMID = 27964450.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Beardsley EK, Saad F, Eigl B, Venner P, Hotte S, Winquist E, Ko YJ, Sridhar SS, Chi KN: A phase II study of patupilone in patients (pts) with metastatic castration- resistant prostate cancer (CRPC) who have progressed after docetaxel. J Clin Oncol; 2009 May 20;27(15_suppl):5139

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PSA response rate (≥50% decline) was the primary endpoint (H0 = 15%, H1 = 25%, α = 0.1, β = 0.2).
  • Baseline characteristics (range): median age 67 (47-85), PSA 212 (2.6-11520), hemoglobin 118 (89-160), median time to progression after docetaxel 1.0 months (0.0-6.0), number of prior chemotherapy regimens 1:2:3+ in 45:28:10 pts, ECOG PS 0-1:2 in 73:10 pts, disease in bone/lymph nodes/viscera in 76/47/14 pts respectively.
  • In 78 pts evaluable for PSA response, PSA declines of ≥30% and ≥50% have occurred in 44/78 (56%) and 35/78 (45%) with a confirmed PSA response in 25 pts (32%).
  • Pain response (2 point decline on 6 point scale) occurred in 36 (51%) of 71 pts eligible for analysis.
  • Median PFS for PSA and non-PSA outcomes (measurable disease/symptomatic progression or death) was 7.6 months (3.7-11.5) and 5.6 months (3.9-7.3) respectively.
  • CONCLUSIONS: Patupilone 8 mg/m<sup>2</sup> every 3 weeks was well tolerated and associated with encouraging PFS, PSA and pain responses in pts with docetaxel resistant/refractory disease.
  • Further investigation of patupilone in this population is warranted.

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  • (PMID = 27964422.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Beer TM, Smith DC, Hussain A, Alonso M, Wang J, Giurescu M, Wang Y, Prostate Cancer Clinical Trials Consortium: Phase II study of first-line sagopilone combined with prednisone in patients with metastatic castration-resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5059

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 5059 Background: Epothilones comprise a new class of microtubule stabilizing agents, and sagopilone is a novel, fully synthetic epothilone that has shown significant activity against a broad range of tumor models.
  • The primary efficacy evaluation was based on PSA decline (≥50% PSA reduction confirmed at least 28 days apart).
  • Median PSA was 107.5 (6.2-1727) ng/ml.
  • Two patients did not meet all eligibility criteria and were excluded from efficacy analyses; 3 additional patients were excluded from PSA decline and progression-free survival analyses due to missing baseline PSA assessment.
  • Twenty of 48 patients (42%; 80% CI: 32%-52%) had a confirmed PSA decline in excess of 50% and 30 (63%; 95% CI: 47%-76%) had a 30% reduction in PSA within 3 months of enrollment.
  • CONCLUSIONS: Sagopilone is active in metastatic chemotherapy-naïve CRPC patients, with probability of PSA decline, measurable disease responses, and PFS approximating the current standard of docetaxel + prednisone.

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  • (PMID = 27962969.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Drewnowska K, Crawford ED, Qian J, Varvel S, Wilk M, Mason L, Kaminetsky J, Huisman TK, Bilowus M, Freedman SJ, Bostwick DG: PCA3: A urine-based genetic assay for detection of prostate cancer in men with elevated PSA. J Clin Oncol; 2009 May 20;27(15_suppl):5054

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PCA3: A urine-based genetic assay for detection of prostate cancer in men with elevated PSA.
  • : 5054 Background: Currently, early detection of prostate cancer relies primarily on an abnormal digital rectal examination (DRE) and an elevated prostate-specific antigen (PSA) level leading to a prostate biopsy.
  • However, because of low positive predictive values, up to 75% of men with elevated PSA and/or suspicious DRE have a negative biopsy.
  • Urine samples were obtained from 974 men with elevated serum PSA (> 2.5ng/ml) and/or abnormal digital rectal examination prior to routine minimum 10-core prostate biopsy following standard study protocol in 30 medical practices.
  • PCA3 and PSA mRNA were isolated, amplified and quantified by magnetic target capture, transcription-mediated amplification, and chemiluminescent hybridization protection assay technologies.
  • The PCA3 value was determined using the ratio of PCA3 mRNA copy number to the PSA mRNA copy number multiplied by 1,000.
  • An additional 106 cases (11%) had only high-grade PIN and/or atypical small acinar proliferation suspicious for cancer (ASAP), and 488 cases (50%) were benign.
  • PCA3 had a specificity of 77% and a sensitivity of 44% for the diagnosis of prostate cancer, while the specificity and sensitivity for serum PSA were 22% and 87%, respectively.
  • CONCLUSIONS: We found that the PCA3 urine test significantly improved the specificity for the detection of prostate cancer compared to serum PSA.

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  • (PMID = 27962974.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Hirsh AL, Lee DJ, Hruby G, Benson MC, McKiernan JM: Does the day or season of operation predict biochemical recurrence after radical prostatectomy? J Clin Oncol; 2009 May 20;27(15_suppl):e16162

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A retrospective analysis of the Columbia Urologic Oncology database was performed.
  • BCR was defined as two consecutive PSA levels > 0.2 ng/ml.
  • RESULTS: The mean age of the men undergoing RP was 61.2 years (37-79), with a mean preoperative PSA of 8.12.
  • Patient age (p=0.68), preoperative PSA (p=0.32), EBL (p=0.51), and positive surgical margin rate (p=0.78) were not significantly different between each day.
  • The particular season and day of the operation were not significantly associated with BCR, and were not independent predictors of BCR in a multivariable model after adjusting for preoperative PSA, Gleason sum, tumor stage, and surgeon.

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  • (PMID = 27963438.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Cervera JM, Garcia-Carbonero I, Girones R, Beltran M, Calderero V, Gonzalvez ML, Domenech M, Diaz N, Jimenez-Lacave P, Gonzalez A: Clinical experience with oral vinorelbine (NVB) plus prednisone as first- or second-line chemotherapy of metastatic hormone- refractory prostate cancer (HRPC). J Clin Oncol; 2009 May 20;27(15_suppl):e16151

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e16151 Background: IV NVB plus hydrocortisone (HC) compared with HC alone resulted in improved clinical benefit, progression-free survival (PFS) and PSA response rate in HRPC.
  • Median PSA 75 ng/mL.
  • 49 p were evaluable for PSA response rate; complete plus partial response was observed in 20.4% (95% CI: 10.2% - 34.3%) and PSA stable was reported in 40.8%.

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  • (PMID = 27963419.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Murphy A, Barlow L, Mann M, Badani K, Benson M, McKiernan J: The robotic era of radical prostatectomy: A retrospective analysis of patient characteristics in contemporary robotic and open prostatectomy. J Clin Oncol; 2009 May 20;27(15_suppl):e16061

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The robotic era of radical prostatectomy: A retrospective analysis of patient characteristics in contemporary robotic and open prostatectomy.
  • METHODS: A total of 1,088 patients who had surgery since the inception of RALRP at our institution (2003-2007) were identified for analysis.
  • Characteristics of the patient pool analyzed included age at surgery, Kattan Nomogram (KN) score, preoperative prostate-specific antigen (PSA), Gleason sum (GS) at biopsy, and pathological tumor stage.
  • The mean preoperative PSA was 6.2, and GS 2-6, 7, and 8-10 of 48.2%, 40.4%, and 11.4%, respectively.
  • There was a significant difference between GS (p<0.0001) and tumor stage (p=0.002) between patients undergoing the two approaches.
  • There were trends in favor of younger age, decreased preoperative PSA, and better KN scores in the RALRP group, but these observations lacked statistical significance (age: p=0.06, PSA: p= 0.07, KN: p=0.15).
  • CONCLUSIONS: Although there is insufficient evidence to declare an overall difference in patient characteristics between these two surgical approaches in our patient population, trends toward lower-risk patients in the RALRP group suggest a series of patient selection forces for this procedure.
  • These observations have the potential to influence the results obtained in retrospective analyses comparing outcomes between RALRP and open RRP.

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  • (PMID = 27963061.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Fleisher M, Danila DC, Leversha M, Rathkopf D, Slovin S, Anand A, Koscuiszka M, Haqq C, Scher HI: Circulating tumor cells (CTC) in patients with metastatic castration-resistant prostate cancer (CRPC) receiving abiraterone acetate (AA) after failure of docetaxel-based chemotherapy. J Clin Oncol; 2009 May 20;27(15_suppl):5049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating tumor cells (CTC) in patients with metastatic castration-resistant prostate cancer (CRPC) receiving abiraterone acetate (AA) after failure of docetaxel-based chemotherapy.
  • AA inhibits CYP17 to decrease serum androgen to undetectable levels.
  • The primary endpoint was a >50% decline in PSA from baseline.
  • The median (IQR) age was 70 yrs (63-79), PSA 99.9 ng/mL (36.4-343), and CTC were 17 (4-49) per 7.5 ml of blood at baseline.
  • Prior systemic therapy included > 3 hormonal therapies in 63%; while 71% received 1, 29% had 2 lines of chemotherapy.
  • Among pts with baseline CTC > 5, the CTC decline to <5 was associated with a decline in PSA by >50% (p< 0.001).
  • PSA declined > 50% in 5 (38%) pts with AR amplification, 2 (25%) pts with gain, and 4 (80%) pts without AR abnormalities.

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  • (PMID = 27962948.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Rodrigues G, Bae K, Roach M, Lawton C, Donnelly B, Grignon D, Hanks G, Porter A, Lepor H, Sandler H: Impact of ultrahigh baseline PSA levels on biochemical and clinical outcomes in two Radiation Therapy Oncology Group (RTOG) prostate clinical trials. J Clin Oncol; 2009 May 20;27(15_suppl):5123

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of ultrahigh baseline PSA levels on biochemical and clinical outcomes in two Radiation Therapy Oncology Group (RTOG) prostate clinical trials.
  • : 5123 Background: Controversy exists regarding the outcomes of prostate cancer patients (PCP) presenting with ultra-high (UH; defined as PSA ≥ 50 ng/ml) PSA levels.
  • The objectives of this study were to assess the outcome of this patient population compared to other high-risk patients and to identify predictors associated with biochemical/clinical outcomes.
  • METHODS: PCP from two phase III RTOG PC clinical trials (9202 and 9413) were divided into two groups; high-risk patients with and without UH baseline PSA level.
  • RESULTS: There are 401 PCP in the UH PSA and 1792 in the non-UH PSA cohort.
  • Median age was 70 years and PCP were evenly distributed across the Gleason groups (2-6, 7, 8-10) for the non-UH (median PSA 22.4 ng/ml) and the UH PSA (median PSA 72.8ng/ml) cohort.
  • The UH PSA cohort had a larger proportion of T1-T2 disease (p = 0.01) and a smaller proportion of Gleason 8 disease (p = 0.04) than the non-UH group.
  • PCP with UH PSA was found to have inferior OS (HR 1.19, 95% CI 1.02-1.39), DM rate (HR 1.51, 95% CI 1.19-1.92), and BF rate (HR 1.50, 95% CI 1.29-1.73) when compared to other high-risk PCP in multivariable modeling.
  • In the UH cohort, PSA level was found to model risk of DM (HR 1.01, 95% CI 1.001-1.02) but not OS and BF.
  • Gleason grade 8-10 was found to consistently predict for poor OS, DM, and BF outcomes (with HR estimates ranging from 1.41 to 2.36) in both the overall and UH cohort multivariable analyses.
  • CONCLUSIONS: UH PSA levels at diagnosis are related with detrimental changes in OS, DM, and BF.

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  • (PMID = 27964407.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Pomara G, Campo G, Milesi C, Casale P, Francesca F: How many lymph nodes may serve as a guideline for a sufficient extended lymph node dissection during radical prostatectomy? J Clin Oncol; 2009 May 20;27(15_suppl):e16102

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: Data from 293 consecutives patients undergone to RP with extended lymphadenectomy were prospectively analyzed [median age 66 (35-79), median PSA 7.98 ng/ml (2.5-35)].
  • Moreover we distinguished and analyzed RPs data of most experienced surgeon: 124 patients [median age 65aa (44-79), median PSA 6.7(2.5-19)].
  • RESULTS: Analyzing all the population, the median number of removed lymph nodes was 15 (1-39).

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  • (PMID = 27963350.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Joensuu TK, Joensuu G, Nokisalmi P, Reddy C, Isola J, Ruutu M, Kouri M, Kupelian P, Hemminki A: A phase I/II trial of gefitinib given concurrently with radiotherapy in patients with nonmetastatic prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e16079

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PSA<20 and good performance status (WHO 0-1) were required.
  • 50.4 Gy (1.8 Gy/day) of 3D-CRT was administered to the tumor, prostate and seminal vesicles, followed by a 22 Gy booster (2 Gy/day) for a 72.4 Gy total dose.
  • Levels of serum TNF, IL-1 α and IL-6 were also evaluated.
  • The estimated PSA-free survival rate at 4 years (Kaplan-Meier) was 97%, hormone-free survival 91% and overall survival 87%.
  • Data on biochemical analyses will be presented.

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  • (PMID = 27963043.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Hudes G, Tagawa S, Whang Y, Qi M, Qin X, Puchalski T, Prabhakar U, O'Brien K, Eisenberger M: A phase I study of CNTO328, an anti-interleukin (IL)-6 monoclonal antibody combined with docetaxel in subjects with metastatic castration-resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5063

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CNTO328, a chimeric anti-IL-6 antibody, has been shown to inhibit prostate tumor growth in xenograft mouse models.
  • Prostate specific antigen (PSA), radiological response, and C-reactive protein (CRP), the best-known surrogate of serum IL-6 bioactivity, were also assessed.
  • Baseline patient characteristics included: median PSA of 59 ng/mL (range 12-1430) and median CRP was 3.85 mg/L (range <1 to 91.3).

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  • (PMID = 27962976.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Igdem S, Abacioglu MU, Alço G, Ibrahimov R, Kefeli A, Çetin I, Turkan S, Okkan S: Postoperative radiotherapy for prostate cancer: Sooner or later? J Clin Oncol; 2009 May 20;27(15_suppl):e16157

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The median PSA level before RT was 0.29ng/ml (range: 0-19ng/mL).
  • Biochemical failure is defined as a post-RT PSA level >0.2ng/mL.
  • Although there was a significant difference in favor of the adjuvantly treated group for biochemical control (81% vs 60%, p = 0.03) in univariate analysis, multivariate analysis demonstrated that higher preoperative PSA level (p = 0.02), and lymph node involvement (p = 0.02) predicted for a worse PSA outcome.

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  • (PMID = 27963417.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Rodriguez Garzotto A, Sepulveda J, Cortijo A, Garcia L, Garcia Rodriguez I, Ciruelos E, Rodriguez Antolin A, Cortes-Funes H, Castellano D: Oral vinorelbine as a fixed-weekly schedule in taxanes-refractory advanced HRPC: A single institution experience. J Clin Oncol; 2009 May 20;27(15_suppl):e16084

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to evaluate the toxicity profile and efficacy of this schedule in terms of PSA response, objective response and clinical benefit (CB) response.
  • PSA response was defined as a >50% fall in PSA from baseline, confirmed by a second PSA value 4 or > weeks later.
  • Progression was defined by objective disease progression or PSA increase of >50% above nadir or >25% above baseline.
  • Pts were monitored clinically and with serial PSA measurements every 1 week.
  • Mean (range) age was 67 years (50-88), median PSA level was 90 ng/ml (1- 4314), and median Gleason score was 7 (6-9).
  • Thirty three of 37 Pts (97%) achieved a decline in serum PSA.
  • The PSA response was observed in 13 pts (35%).
  • Further studies will be evaluated in chemo-naive and/or elderly population.

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  • (PMID = 27963107.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Petrylak DP, Resto-Garces K, Tibyan M, Mohile SG: A phase I open-label study using lenalidomide and docetaxel in castration- resistant prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):5156

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Eligibility requirements include progressive measurable disease or rising PSA levels after antiandrogen withdrawal and < 2 prior chemotherapy regimens.
  • Pts were given prednisone 5 mg po |[BI]D continuously and 8 mg of decadron 12, 8 and 1 hour prior to D without prophylactic anticoagulation.
  • Pt characteristics include median age of 70 yrs (range 47-85), median baseline PSA of 101.9 ng/ml (range 5.9-7480), 14 pts (41%) had received prior chemotherapy (7 with 2 prior regimens).
  • Other Grade 3/4 toxicities observed after cycle 1 included deep venous thrombosis (2 pts), grade 3 neutropenia (2 pts), grade 3 facial edema (1 pt) Of 31 pts evaluable for post treatment PSA declines; 8/17 (47%) untreated pts 7/14 (50%) previoustly treated pts had a >50% decline in PSA.

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  • (PMID = 27964474.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Sonpavde G, Frolov A, Macdonell V, Hayes TG, Mims MP, Ayala GE, Wheeler TM, Thompson TC, Ittman MM, Kadmon D: Bortezomib as brief neoadjuvant therapy for localized high-risk prostate cancer (PCa) followed by radical prostatectomy (RP). J Clin Oncol; 2009 May 20;27(15_suppl):5127

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological evidence of adenocarcinoma of the prostate was required with clinical stage T<sub>1c</sub> or T<sub>2a</sub> with Gleason 8-10 disease, or clinical stage T<sub>2b</sub>-T<sub>2c</sub> with Gleason grade 7 and PSA of >10 ng/mL, or clinical stage T<sub>3</sub>.
  • Cytopathic effects (cytolysis, nuclear pyknosis) were commonly seen compared to baseline tumor.
  • Two of 8 evaluable patients had a >50% decrease in serum PSA with bortezomib treatment; 3 others had PSA declines of 14%, 25%, and 45%, respectively; 1 patient had no change, and 2 displayed PSA increases.
  • A comprehensive toxicity analysis will be presented.

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  • (PMID = 27964403.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Vaishampayan UN, Heilbrun LK, Heath EI, Smith DW, Dickow B, Baranowski K, Powell I, Fontana J: Phase II trial of bevacizumab (B) and oral satraplatin (S) and prednisone in docetaxel pretreated metastatic castrate resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):e16028

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary endpoint was time to progression defined as a skeletal event, new areas of metastases on bone scans or per RECIST criteria for measurable disease.
  • RESULTS: 19 of 28 patients have been enrolled to date; 7 African American and 12 Caucasian,, with median age of 68.5 years and median pretherapy PSA of 137.8 ng/mL (range 16.8-994 ng/mL).
  • Measurable disease progression was noted in 5 patients, bone scan progression in 6 patients, progression of both in 3 patients, and PSA only progression in 5 patients.
  • 7 patients had a PSA decline of which 4 patients had a ≥30% PSA decline.

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  • (PMID = 27962967.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Scher HI, Beer TM, Higano CS, Taplin M, Efstathiou E, Anand A, Hung D, Hirmand M, Fleisher M, Prostate Cancer Clinical Trials Consortium: Antitumor activity of MDV3100 in a phase I/II study of castration-resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5011

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Antitumor activity of MDV3100 in a Phase I/II trial was assessed by prostate-specific antigen (PSA), soft tissue and osseous disease, circulating tumor cells (CTC), and time on treatment.
  • PSA declines (>50% from baseline) were observed at week 12 in 57% (37/65) of naïve and 45% (22/49) of post-chemo pts.
  • Data suggest a dose-response trend particularly in post-chemo pts where PSA responses were 32% at 60 and 150 mg/day and 58% at 240 and 360 mg/day.
  • CONCLUSIONS: MDV3100 is a promising candidate for the treatment of prostate cancer assessed by PSA, imaging, CTC, and time on treatment.

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  • (PMID = 27962905.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Glode LM, Tangen CM, Hussain MH, Wood DP Jr, Swanson GP, Quinn DI, Dawson N, Balzer-Haas N, Crawford ED, Thompson IM: Southwest Oncology Group S9921: Prolonged event-free survival in high-risk prostate cancer (PC) patients receiving adjuvant androgen deprivation. J Clin Oncol; 2009 May 20;27(15_suppl):5009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The DSMC has approved this analysis.
  • PSA was to be assessed every 3 mo for 5 yrs and then every 6 mo for 10 more yrs.
  • PSA relapse was defined as 3 consecutive measurements > 0.2 ng/ml.
  • Risk groups based on eligibility criteria are as follows: Risk Group 1= positive margins or extraprostatic extension only with Gleason 7; elevated PSA (pre-op > 15 ng/ml), or had a pre-op PSA > 10 ng/ml and a biopsy Gleason 7(N=113); Risk Group 2 = seminal vesicle invasion or Gleason >/= 8, but no positive nodes (N=240), Risk Group 3 =positive nodes (N=69), 397 patients from both arms who completed 2 years of CAB were assessed for time to testosterone (T) recovery.
  • CONCLUSIONS: These data indicate a markedly low PSA relapse and death rates in high risk PC patients who received CAB.

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  • (PMID = 27962889.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Noguchi M, Uemura H, Kumon H, Nasu Y, Hirao Y, Matsuoka K, Kakuma T, Yamada A, Itoh K: A randomized trial of personalized peptide vaccine (PPV) plus low-dose estramustine (EMP) versus full-dose EMP in patients with hormone-refractory prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):3007

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This randomized study evaluated the anti-tumor effect and safety of PPV plus a low-dose EMP compared with full dose EMP for patients with hormone-refractory prostate cancer (HRPC).
  • Pts were randomized to arm A; PPV plus low-dose EMP (280 mg/day) or arm B; full dose EMP (560 mg/day) according to age and PSA levels.
  • Disease progression (PD) was defined as three consecutive and 125% increase from baseline PSA levels at least two weeks apart or objective PD by RECIST criteria.
  • The main pts characteristics are (arm A/B): median age 71/69 years, EOCG performance status 0/1 96%/4% and 100%/0%, HLA A2/A24/A2A24 40%/32%/28% and 54%/27%/19%, median PSA 27/25 ng/ml, and metastatic HRPC 96%/85%.
  • All pts were evaluable for their response at the time of interim analysis.
  • CONCLUSIONS: PPV plus low-dose EMP was associated with improvement in PSA-based PFS compared to full-dose EMP alone.

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  • (PMID = 27962045.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Hoffman KE, D'Amico AV: Prostate cancer screening practice among men age 75 and older: Results from a national survey. J Clin Oncol; 2009 May 20;27(15_suppl):e16034

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study evaluated the use of prostate specific antigen (PSA) screening among men age 75 and older prior to this declaration.
  • Univariable and multivariable logistic regression was used to determine factors associated with PSA screening.
  • More than half (51.6%) underwent PSA screening within the previous two years.
  • Men who reported poor health status (42.2 vs. 55.2%, p=0.005) and men who had difficulty with at least one IADL (37.4 vs. 53.3%, p=0.010) were less likely to have a screening PSA.
  • After adjustment for age, race, education status, and physician access, poor health status (adjusted odds (AOR): 0.70, 95% CI (CI): 0.45 to 1.10; p = 0.119), two or more significant diseases (AOR: 0.78, CI: 0.48 to 1.27; p = 0.333) and difficulty with at least one IADL (AOR: 0.71, CI: 0.42, 1.20; p = 0.202) were not associated with the use of PSA screening.
  • Of the 104 men likely to live for five years or less because of poor health, 35.0% underwent PSA screening.
  • CONCLUSIONS: Health status, a predictor of life expectancy, should be considered when determining which men receive PSA screening.
  • This would reduce the use of PSA screening in men unlikely to benefit.

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  • (PMID = 27962959.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Ryan C, Efstathiou E, Smith M, Taplin M, Bubley G, Logothetis C, Kheoh T, Haqq C, Molina A, Small EJ: Phase II multicenter study of chemotherapy (chemo)-naive castration-resistant prostate cancer (CRPC) not exposed to ketoconazole (keto), treated with abiraterone acetate (AA) plus prednisone. J Clin Oncol; 2009 May 20;27(15_suppl):5046

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Results: At baseline median age was 71.0 (range 52-85) yrs and median PSA was 24.7 (range 7.1-1110.0) ng/mL;19/26 pts (73%) had an ECOG PS of 0 and 7/26 (27%) had PS of 1; the median number of prior hormonal therapies was 2; all pts were on LHRHa and 73% of pts had received anti-androgen, all of whom had undergone prior anti-androgen withdrawal.
  • Pts were evaluated at each cycle for PSA response according to PSAWG criteria.
  • 27 pts have available data for PSA response.
  • Total maximal PSA declines of ≥30%, ≥50%, ≥90% were observed in 89% (24/27), 85% (23/27) and 41% (11/27) pts, respectively.
  • Week 12 PSA declines displayed a similar and sustained trend: ≥30%, ≥50% and ≥90% PSA decline in 82%, 78%, and 26% of pts.
  • Post-treatment ECOG PS score was 0 in 24 (92%) pts: 19% experienced improvement in PS (PS 1 to 0 in 5 pts) and 19/19 pts maintained a PS of 0; Median time to PSA progression has not been reached.
  • CONCLUSIONS: Abiraterone acetate plus prednisone has significant anti-cancer activity in patients with metastatic CRPC not previously treated with ketoconazole or chemotherapy, as demonstrated by declines in PSA and improvement in performance status, and is well-tolerated.

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  • (PMID = 27962951.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Prins R, Rademacher BL, Mongoue-Tchokote S, Eilers KM, Beer TM: C-reactive protein as adverse prognostic marker for men with castration-resistant prostate cancer (CRPC): Confirmatory results. J Clin Oncol; 2009 May 20;27(15_suppl):5168

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 5168 Background: We previously reported that higher serum concentrations of C-reactive protein (CRP) are associated with shorter survival in men with metastatic CRPC treated with docetaxel-containing chemotherapy.
  • 91% of patients had metastases and 9% had PSA-only disease.
  • In addition to CRP, we examined alkaline phosphatase, hemoglobin, age, ECOG PS, and PSA collected at study entry.

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  • (PMID = 27964500.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Mardjuadi F, Medioni J, Kerger J, Canon JL, Duck L, Oudard S, Clausse M, D'Hondt L, Moxhon A, Machiels JP: A phase I study of sorafenib in association with docetaxel-prednisone in chemonaive metastatic castration-resistant prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):5153

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PK analysis showed that mean C<sub>max</sub> and AUC of D were increased at cycle 2 in cohort 2, 3, and 4 indicating a PK interaction dependent on the exposure to S.
  • PSA response (> 50% in PSA decrease) was recorded in 15 out of 20 pts.
  • PK analysis revealed an interaction between D and S that may explain the high rate of febrile neutropenia and Gr4 neutropenia.

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  • (PMID = 27964477.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Gernone A, Pagliarulo V, Trabucco S: Prognostic role of somatostatin receptor subtypes in human prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e16120

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • NED of PC correlates with poor prognosis and tumor progression during androgen-deprivation therapy.
  • Patient characteristics included: median age 68 years (range 45-83), median baseline PSA: 70 ng/ml (range 0.3-200), median ECOG Performance Status: 1 (range 0-2), Gleason score ≥ 7, medium serum level of CgA was 56.2 nmol/L (range 0.5-120).
  • The PSA and CgA levels were not correlated with clinical outcome.

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  • (PMID = 27963398.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Patel P, Young JG, Mautner V, Ashdown D, Bonney S, Pineda RG, Collins SI, Searle PF, Hull D, Peers E, Chester J, Wallace DM, Doherty A, Leung H, Young LS, James ND: A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984. Mol Ther; 2009 Jul;17(7):1292-1299

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : We report a phase I/II clinical trial in prostate cancer (PCa) using direct intraprostatic injection of a replication defective adenovirus vector (CTL102) encoding bacterial nitroreductase (NTR) in conjunction with systemic prodrug CB1954.
  • Based on acceptable safety data and indications of prostate-specific antigen (PSA) responses, an extended cohort received virus at a single dose level plus prodrug.
  • Immunohistochemistry of resected prostate demonstrated NTR staining in tumor and glandular epithelium at all dose levels [5 × 10<sup>10</sup>-1 × 10<sup>12</sup> virus particles (vp)].
  • A total of 19 patients received virus plus prodrug and 14 of these had a repeat treatment; minimal toxicity was observed and there was preliminary evidence of change in PSA kinetics, with an increase in the time to 10% PSA progression in 6 out of 18 patients at 6 months.

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  • [Copyright] Copyright © 2009 The American Society of Gene Therapy. Published by Elsevier Inc. All rights reserved.
  • (PMID = 28178475.001).
  • [ISSN] 1525-0024
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Lin J, Beer TM, Ryan CJ, Mathew P, Wilding G, Morris M, Callahan JA, Gordon G, Reich S, Carducci MA: A randomized, phase II study of ATN-224 in patients with biochemically relapsed, hormone-naive prostate cancer: A DOD/PCF Prostate Cancer Clinical Trials Consortium trial. J Clin Oncol; 2009 May 20;27(15_suppl):5135

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: PCa pts with PSA doubling time (PSADT) of < 12 months, no radiographic evidence of metastasis, no hormonal therapy within 6 months were enrolled.
  • PSA progression was defined as at least a 50% increase in PSA and >5 ng/mL increase from baseline or post-treatment nadir and confirmed.
  • Endpoints included the proportion of pts who did not have PSA progression for 24 weeks, change in PSA slope/PSADT, and assessment of safety and tolerability.
  • Fourteen of 27 (52%) in the low dose and 6/25 (24%) in the high dose cohort were PSA progression free for 24 weeks.
  • One patient in high dose cohort showed PSA >50% decrease of 40 days duration.
  • Pre- and on-treatment PSA kinetics are shown below.
  • CONCLUSIONS: ATN-224 may have biologic activity in men with androgen-dependent PCa at low doses, as demonstrated by > 50% of pts being PSA progression free at 6 month and a significant decrease in mean PSA slope.

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  • (PMID = 27964427.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Armstrong AJ, Halabi S, Tannock IF, George DJ, DeWit R, Eisenberger M: Development of risk groups in metastatic castration-resistant prostate cancer (mCRPC) to facilitate the identification of active chemotherapy regimens. J Clin Oncol; 2009 May 20;27(15_suppl):5137

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 5137 Background: Our aim was to develop and validate clinically applicable predictive factors for a >30% PSA decline 3 months following chemotherapy initiation, and to assess the performance of a risk-group based classification in predicting PSA declines and overall survival (OS) in men receiving chemotherapy for mCRPC.
  • METHODS: In TAX327, 1006 men with mCRPC were randomized to receive docetaxel (D) in two schedules, or mitoxantrone (M), each with prednisone: 989 provided data on PSA decline at 3 months.
  • Predictive factors for a >30% 3-month decline in PSA levels were identified using multivariate logistic regression in D treated men (n = 656) and validated in M treated men (n = 333).
  • Risk factors were combined to form risk groups to predict PSA declines, OS, tumor, and pain responses.
  • RESULTS: In multivariate analysis, four independent risk factors predicted for absence of >30% decline in 3-month PSA: significant baseline pain (OR 0.63 p = 0.02), visceral metastases (OR 0.66, p = 0.03), anemia (hemoglobin <13 g/dl, OR 0.72 p = 0.07), and bone scan progression at baseline (OR 0.60 p = 0.009).
  • Risk groups (good, intermediate, poor) were developed with median OS of 25.7 (95% CI 23.3-28.6), 18.7 (17.3-19.7), and 12.8 (11.5-14.6) months, respectively (p < 0.0001), and >30% PSA decline in 78, 66, and 58 percent of men (p < 0.001).
  • In the validation M cohort, similar trends for PSA declines and OS were noted across risk groups (OS 22.5, 16.0, 11.8 mo, p < 0.001).
  • CONCLUSIONS: Risk groups have been identified and internally validated that predict PSA decline and OS in men with mCRPC.
  • This classification may facilitate evaluation of new regimens of systemic therapy that warrant definitive testing in comparison to docetaxel and prednisone in phase III trials.

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  • (PMID = 27964425.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Cetnar JP, Rosen MA, Vaughn DJ, Haas NB, Troxel AB, Song H, Adluru G, Flaherty KT, O'Dwyer PJ, Amaravadi RK: Phase II study of sorafenib and docetaxel in men with metastatic castration resistant prostate cancer (mCRPC). J Clin Oncol; 2009 May 20;27(15_suppl):e16055

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e16055 Background: Previous trials of the antiangiogenic kinase inhibitor sorafenib in mCRPC have reported PSA elevation accompanying radiographic response, and evidence that sorafenib may potentiate docetaxel (dxl) myelosuppression.
  • The primary endpoint was PSA response rate (>50% PSA decline).
  • Secondary endpoints were vascular response rate (>20% decline in area under the gadolinium curve [AUC60]), toxicity rates, and time to progression (TTP).
  • PSA-only progression (2 consecutive PSA rises) was confirmed by a third PSA rise or radiographic progression after a 21-day drug holiday.
  • RESULTS: Six of 13 enrolled patients (46%) had a PSA response.
  • A median PSA increase of 37% was observed in 73% of patients after 1 week of sorafenib.
  • Elevated PSA values in men treated with sorafenib and dxl does not always reflect disease progression.
  • DCE-MRI can capture sorafenib's impairment of tumor vasculature in osseous metastases and rebound angiogenesis during drug holidays.

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  • (PMID = 27962998.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Chi KN, Hotte SJ, Yu E, Tu D, Eigl B, Tannock I, Saad F, North S, Powers J, Eisenhauer E, National Cancer Institute of Canada Clinical Trials Group: Mature results of a randomized phase II study of OGX-011 in combination with docetaxel/prednisone versus docetaxel/prednisone in patients with metastatic castration-resistant prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):5012

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary endpoint was PSA response rate (RR).
  • Planned sample size was 40/arm: Arm A the hypotheses (PSA RR<40% vs. >60%) could be tested at 10% β and 10% α, Arm B the true PSA RR could be estimated with half-width of the 90% CI<13% if PSA RR=40%.
  • At this analysis time, all pts are off therapy and 49 have died.
  • One pt was ineligible but included in ITT survival analysis.
  • Baseline characteristics were similar: median age 69 (49-87), PSA >100 μg/L in 51%, Hgb ≥100 g/L in 98%, alk phos >ULN in 44%, LDH >ULN in 36%, ECOG performance status (PS) 0:1 in 51%:49%, bone/lymph node/visceral metastases in 69%/50%/28%.
  • Mean serum clusterin change on day 1 cycle 2 was -18% in Arm A and +8% in Arm B (p = 0.0005).
  • PSA RR was 58% (Arm A) and 54% (Arm B).
  • PSA declines at 12 weeks of any/>30%/>50% was observed in 87%/65%/45% (Arm A) and 68%/58%/34% (Arm B).
  • PSA/objective disease progression as best response occurred in 0%/4% (Arm A), and 3%/17% (Arm B).
  • Variables predictive of OS on multivariate analysis: PS 0 vs 1 (p = 0.0002), presence of visceral metastasis (p = 0.006) and treatment assignment (HR = 0.54 [0.29-0.97], p = 0.04).
  • CONCLUSIONS: The PSA RR in both arms met criterion for further study.
  • OGX reduced serum clusterin and OS appears superior with DOC/OGX.

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  • (PMID = 27962904.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Nanda A, Chen M, Moran BJ, Braccioforte MH, Dosoretz D, Salenius S, Katin M, Ross R, D'Amico AV: Predictors of prostate cancer-specific mortality in elderly men with intermediate-risk prostate cancer treated with radiation therapy. J Clin Oncol; 2009 May 20;27(15_suppl):9543

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The study cohort comprised 1,978 men of median age 71 (interquartile range [IQR], 66-75) years with intermediate-risk prostate cancer (Gleason score 7 with PSA 20 ng/mL or less and tumor category T2c or less).
  • Fine and Gray's multivariable competing risks regression was used to assess whether presence of cardiovascular disease (CVD), age, treatment, year of brachytherapy, PSA level, or tumor category were associated with the risk of PCSM.
  • The presence of CVD was significantly associated with a decreased risk of PCSM (AHR 0.20, 95% CI 0.04 - 0.99, P = 0.05), whereas an increasing PSA level was significantly associated with an increased risk of PCSM (AHR 1.14, 95% CI 1.02 - 1.27, P = 0.02).
  • In the absence of CVD, cumulative incidence estimates of PCSM were higher (P = 0.03) in men with PSA levels above as compared to the median PSA level (7.3 ng/mL) or less; however, in the setting of CVD there was no difference (P = 0.27) in these estimates stratified by the median PSA level (6.9 ng/mL).
  • CONCLUSIONS: Detection of intermediate-risk prostate cancer in elderly men without CVD at lower PSA levels is associated with a lower risk of PCSM; this risk reduction is not observed in men with known CVD.

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  • (PMID = 27963605.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Kolevska T, Ryan CJ, Huey V, Weisberg L, Wang S, Baer D, Ghadialy A, Goldstein D, Fireman B, Fehrenbacher L: Phase II trial of nab-paclitaxel as first-line therapy of hormone refractory metastatic prostate cancer (HRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5152

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nab-paclitaxel, an albumin-bound nanopaticle form of paclitaxel, delivers paclitaxel without steroids, requires only 30 minutes infusion time and has favorable toxicity profile that may be more tolerable but effective in patients with prostate cancer.
  • Primary endpoint was efficacy based on prostate-specific antigen (PSA) response.
  • PSA response was PSA decrease of >50%, progressive disease (PD) was PSA increase of >25%, stable disease (SD) was <25% PSA increase or <50% decrease sustained longer that 8 weeks.
  • PSA response was seen in 9 (25%) patients and SD in 15 patients (43%), with an overall response rate of 25% and clinical benefit of 68%.

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  • (PMID = 27964449.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Gómez-Pinillos A, Ballard H, Shelton G, Reilly MM, Chachoua A, Taneja S, Ferrari AC: Sequential and intermittent docetaxel (D) and imatinib (Im) in hormone-refractory prostate cancer patients (NYU 04-47). J Clin Oncol; 2009 May 20;27(15_suppl):e16108

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sequential block of the cell cycle progression in G2-M followed by G1-S may increase anti-tumor responses.
  • METHODS: Eligibility: at least 2 prior hormone manipulations and up to one prior chemotherapy, PSA>5ng/ml, ECOG PS 0-2.
  • A two steps design was planned to assess activity (PSA decline >50% and/or measurable or symptomatic response) and tolerance including interim analysis to determine if 37 patients (pts) should be enrolled.
  • There were 98 cycles of trial therapy administered and 9 events (PSA or bone progression) registered at the time of analysis.
  • Median baseline PSA 73,5ng/ml (2.1-1954.3).
  • PSA decline >50% observed in 7/15pts (46.67%) of which 3 was >80% (20%).
  • PSA decline <50%, observed in 6/15(40%).
  • CONCLUSIONS: Sequential and intermittent D every 21 days and Im for 14 days is tolerable and active by PSA decline and symptomatic improvement.

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  • (PMID = 27963331.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Oh WK, Febbo PG, Richie JP, Fennessy FM, Scibelli G, Hayes JH, Choueiri TK, Tempany CM, Taplin ME, Ross RW: A phase II study of neoadjuvant chemotherapy with docetaxel and bevacizumab in patients (pts) with high-risk localized prostate cancer: A Prostate Cancer Clinical Trials Consortium trial. J Clin Oncol; 2009 May 20;27(15_suppl):5060

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Eligibility included any of the following: PSA > 20 ng/ml or PSA velocity > 2 ng/ml/yr, cT3 disease, any biopsy Gleason 8-10, Gleason 7 with T3 disease by endorectal (er) MRI.
  • Also, >50% biopsy cores involved and either Gleason 7 or PSA >10 or cT2 disease were eligible.
  • The primary endpoint was erMRI partial response (PR, defined here as >50% decrease in tumor volume) in a single target lesion after chemotherapy.
  • Median PSA was 10.5 ng/ml (range 2.1-72.5).
  • Of 23 evaluable pts to date, the median decline in the maximal tumor volume by erMRI was -45% (range -84% to 110%).
  • Any PSA decline was noted in 22/34 (65%) evaluable pts, with 18% having a >50% decline.
  • Only 1 pt stopped treatment because of a rising PSA.
  • CONCLUSIONS: Neoadjuvant docetaxel and bevacizumab demonstrates clinical evidence of activity in men with high-risk localized prostate cancer, with a 39% PR rate by erMRI and PSA declines noted in 65%.

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  • (PMID = 27962979.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Libener R, Montefiore F, Bonini F, Ruggero L, Maffezzini M, Puntoni M, Nanni L, Paganuzzi M, Puntoni R, Betta P: Sensitivity and specificity of osteopontin (OPN) versus prostate-specific antigen (PSA) in prostate carcinoma (PCa): A case- control study. J Clin Oncol; 2009 May 20;27(15_suppl):e16082

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sensitivity and specificity of osteopontin (OPN) versus prostate-specific antigen (PSA) in prostate carcinoma (PCa): A case- control study.
  • : e16082 Background: OPN is a secreted adhesive glycoprotein overexpressed in human cancers.
  • This study intends to determine if measuring serum OPN and PSA levels can provide informative markers for the detection of PCa.
  • METHODS: Serum total PSA using a chemiluminescent immunoassay system (Hybritech PSA, DxI Beckman Coulter, Inc.) and plasma OPN using an ELISA technique (R&D Systems, Inc.) were measured in 263 male subjects referred for diagnostic prostate biopsy, including 167 control patients with benign prostate pathology (mean age: 65.30; median age: 66; SD: 6.80; range 46-83) and 96 PCa patients (mean age: 66.80; median age: 68; SD: 7.90; range 47-86).
  • The relationship between sensitivity and specificity was profiled by receiver operating characteristic (ROC) curves of OPN and PSA.
  • RESULTS: Both markers levels were higher in PCa patients (OPN 51.98 ng/ml, SD 32.64, range 5.9-169.54; PSA 12.91 ng/ml, SD 14.73, range 1.69-90) than in controls (OPN 49.93 ng/m, SD 27.78, range 4.15-146.34; PSA 8.04 ng/ml, SD 5.94, range 0.46-45), although the elevation was significant (p<0.001) for PSA but not for OPN (p=0.59).
  • The increase of serum OPN level paralleled the increase of the tumour size, defined by the T stage, and was more striking for T ≥2 PCa than for T1 PCa.
  • The increase of PSA, related to the tumour size, was less evident and was observed only in high stage (T3) tumours.
  • For PSA, a cut-off value of 4 ng/ml had a sensitivity of 93% with a specificity of 13%.
  • CONCLUSIONS: OPN and PSA are not correlated and therefore their combined evaluation in a larger study group could provide a novel insight into the natural history of PCa.

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  • (PMID = 27963103.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Lubaroff DM, Vaena DA, Williams RD, Joudi FN, Smith MC, Zehr PS, Eastman J, Griffith K, Madsen TM, Johnson K: A phase II trial of an adenovirus/PSA vaccine for prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):3065

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase II trial of an adenovirus/PSA vaccine for prostate cancer.
  • : 3065 Background: Our phase I adenovirus/PSA vaccine trial has proven the vaccine is safe.
  • We are conducting a phase II clinical trial with two separate protocols for patients with recurrent or hormone-refractory prostate cancer assessing toxicity, immune responses, and change in PSA levels.
  • Each injection consists of 108 pfu of Ad/PSA vaccine suspended in a collagen matrix.
  • Median patient age is 70 years (range 61-84), and median enrollment PSA levels are 0.79 ng/ml (range 0.24-3.93) in Protocol 1 and 5.47 ng/ml (range 0.29-11.17) in Protocol 2.
  • Preliminary results show 86% in both protocols demonstrating anti-PSA T cell responses above preinjection levels.
  • 25% have stable serum PSA levels, 50% have decreased levels, and 25% have increased levels.
  • 11% have stable serum prostatic acid phosphatase (PAP) levels, 56% have decreased levels, and 33% have increased levels.
  • CONCLUSIONS: These early results from the first few months of this phase II trial demonstrate the induction of anti-PSA T-cell responses in a high percentage of the vaccinated patients and stabilization or declines in serum PSA and PAP levels.

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  • (PMID = 27962013.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Pinthus JH, Farrokhyar F, Hassouna MM, Woods E, Orovan WL: Two-years biochemical failure-free survival following high intensity focused ultrasound (HIFU) for localized prostate cancer: Prospective single center study of 196 patients. J Clin Oncol; 2009 May 20;27(15_suppl):5117

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients were followed (median: 12; range 3-24 months) with PSA measurement every 3 months.
  • Patients who received prior radiation or hormonal therapy (n=25) and patient for whom at least 2 consecutive PSA measurements were not available (n = 32) were excluded, leaving a total of 196 patients for analysis.
  • Mean pre-treatment PSA was 6.9+3.3.
  • Biopsy Gleason scores at diagnosis (median 9 cores) were 5, 6, 3+4, 4+3 in 1, 91, 66 and 38 patients, respectively.
  • Biochemical failure (BCF) is reported using the Stephenson (PSA >0.4ng/ml and rising), Horwitz (2 consecutive increases of at least 0.5ng/ml) and Phoenix (nadir+2ng/ml) definitions.
  • RESULTS: 196 patients (age: 64+8) met the inclusion criteria for analysis.
  • Mean and median absolute PSA nadir levels were 0.28+0.53 and 0.06 ng/ml respectively.
  • Predictors of BCF were absolute nadir [HR: 3.0 (2.3-3.8)] and pre-treatment PSA [HR: 1.1 (1.0-1.2)].
  • Pre-HIFU PSA and post-HIFU PSA nadir levels are predictors for BCF.

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  • (PMID = 27964388.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Chi D, Hirsch AE, Gignac GA: Biochemical failure after radiation therapy for prostate cancer: Racial differences. J Clin Oncol; 2009 May 20;27(15_suppl):e16071

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The generalizability of these results assumes similar tumor biology among all races.
  • We set out to examine biochemical failure (PSA failure) rates in a cohort of pts after definitive external beam radiation (EBRT) in the racially diverse population at our institution.
  • We excluded from analysis pts who received brachytherapy, salvage, adjuvant or palliative radiation.
  • Race, country of origin, diagnostic data, pre- and post-treatment PSA, Gleason score (GS), clinical stage (CS), and treatment history were reviewed.
  • CS was based on the original clinician's assessment at time of diagnosis.
  • PSA failures were defined using 1996 ASTRO criteria.
  • Statistical analysis was performed using Fisher's Exact test.
  • The white cohort had a high proportion of pts with a pretreatment PSA <10 ng/ml (66%) as compared to the nonwhite cohort (46%).
  • PSA failure rate was 7% for the white cohort and 13% for nonwhite (p = 0.41).
  • CONCLUSIONS: In this retrospective analysis, there was no statistical difference among races with regard to PSA failure rates.
  • The PSA and Gleason trends in each cohort were consistent with published data on this topic.

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  • (PMID = 27963037.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Mohebtash M, Madan RA, Arlen PM, Rauckhorst M, Tsang KY, Cereda V, Vergati M, Poole DJ, Dahut WL, Schlom J, Gulley JL: Phase I trial of targeted therapy with PSA-TRICOM vaccine (V) and ipilimumab (ipi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5144

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase I trial of targeted therapy with PSA-TRICOM vaccine (V) and ipilimumab (ipi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).
  • PSA-TRICOM V is composed of poxviral vectors encoding PSA and 3 costimulatory molecules (ICAM-I, LFA-3, and B7.1) and has clinical activity in mCRPC.
  • Ipi blocks CTLA-4, a T-cell downregulatory receptor, has clinical activity in mCRPC as monotherapy and has also been shown to enhance anti-tumor responses in combination with V in preclinical studies.
  • Median PSA doubling time (DT) ↑ from 2.2 mo at baseline to 3.7 on study (p = 0.17).
  • 5 of 9 had ≥ 50% ↓ in PSA from peak during study and 1 had a sustained ↓ PSA > 95% from baseline.
  • 1 had a sustained ↓ in PSA > 99% from baseline and is still on study after 12 mo.
  • Median PSA DT ↑ > 3-fold from 2.6 mo at baseline to 8.2 on study (p = 0.01) in DL4.
  • The 24 chemo-naïve pts had PSA DT ↑ from 2.5 to 6 mo (p = 0.003).
  • 14 of 30 pts had a PSA ↓ from baseline or peak PSA on study.
  • 2 of 14 had no irAE, 12 showed ≥ G2 irAE temporally associated with PSA ↓.

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  • (PMID = 27964446.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Pinski JK, Goldman B, Dorff T, Mack P, Lara P Jr, van Veldhuizen P, Quinn D, Hussain MH, Thompson IM: SWOG S0354: A phase II trial of CNTO328, a monoclonal antibody against interleukin-6 (IL-6), in chemotherapy pretreated patients (pts) with castration- resistant prostate cancer (CRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5143

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary endpoint was PSA response rate (RR) defined as ≥50% reduction.
  • Two (3.7%; 95% CI: 0.5%, 12.8%) had PSA response.
  • CONCLUSIONS: CNTO328 was well-tolerated and resulted in a PSA RR of 3.7% and RECIST SD rate of 21%.

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  • (PMID = 27964447.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Lee RJ, Stott SL, Nagrath S, Ulkus LE, Dahl DM, Smith MR, Toner M, Maheswaran S, Haber DA: Analyses of circulating tumor cell (CTC) dynamics and treatment response in prostate cancer using the CTC-chip microfluidic device. J Clin Oncol; 2009 May 20;27(15_suppl):5149

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analyses of circulating tumor cell (CTC) dynamics and treatment response in prostate cancer using the CTC-chip microfluidic device.
  • In localized disease, CTCs may be indicative of tumor invasiveness.
  • Molecular analyses of CTCs through this minimally invasive technique may provide insights into disease behavior, whereas sampling of metastatic deposits in bone (the predominant site of prostate metastasis) is not feasible.
  • Quantities were determined using cytokeratin- and PSA-based staining and enumeration.
  • In some cases, molecular analyses for the TMPRSS2:ERG chromosomal translocation were performed using FISH in intact cells or nuclei, or RT-PCR in extracted RNA.
  • RESULTS: PSA-stained CTCs were captured in all patients.
  • In patients with metastatic disease undergoing either ADT or chemotherapy, CTC quantities generally corresponded with changes in serum PSA and radiographic assessments.
  • CONCLUSIONS: These studies are the first to use the highly sensitive CTC-Chip technology to assess dynamic changes in CTCs in patients undergoing prostatectomy, ADT, or chemotherapy.

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  • (PMID = 27964441.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Nozawa M, Yoshida M, Saito Y, Nakagawa M, Ozeki T, Yoshikawa M, Aono Y, Uemura H: Serum selenium and risk of prostate cancer in Japanese men. J Clin Oncol; 2009 May 20;27(15_suppl):e16166

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum selenium and risk of prostate cancer in Japanese men.
  • We examined the association between serum selenium levels and risk of prostate cancer in men who received a prostate biopsy in our hospital.
  • METHODS: Our prospective study included 82 patients who received a prostate biopsy based on elevated PSA levels over 4.0ng/ml.
  • Serum from each patient was sampled to determine the selenium level at the time of biopsy.
  • RESULTS: The mean serum selenium levels in the case and control group were 120.4 (SD, 14.4) ng/mL and 118.5 (SD, 16.1) ng/mL, respectively (p = 0.588).
  • Serum selenium levels at biopsy were not associated with risk of prostate cancer diagnosis.
  • In the case group, the mean serum selenium levels in patients diagnosed with 6 or less in Gleason score and 7 or more were 121.0 (SD, 9.9) ng/mL (n = 14) and 120.1 (SD, 16.1) ng/mL (n = 33), respectively (p = 0.851).
  • Serum selenium levels at biopsy were not associated with Gleason score in the case group.
  • An inverse association between serum selenium and PSA levels at biopsy was observed (p = 0.030).
  • No correlation was observed between serum selenium level and age at biopsy.
  • CONCLUSIONS: From this study, serum selenium level cannot predict the result of prostate biopsy.
  • The inverse association between serum selenium and PSA levels may suggest that low selenium levels are associated with an increased incidence of prostate cancer.

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  • (PMID = 27963436.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Dickstein RJ, Kreshover JE, Milose JC, Gignac GA: Metastatic prostate cancer at diagnosis: Clinical presentation in the post-PSA era. J Clin Oncol; 2009 May 20;27(15_suppl):e16159

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic prostate cancer at diagnosis: Clinical presentation in the post-PSA era.
  • Prostate-specific antigen (PSA) screening dramatically diminished the presentation of patients (pts) with metastatic CaP from 5.6% in 1990 to 1.5% in 2003 as evidenced by the CaPSURE database.
  • Our institution has a uniquely diverse demographic and socioeconomic population and we sought to identify pts with metastatic CaP at diagnosis to evaluate contributing factors.
  • RESULTS: Sixty-one pts presented initially with metastatic CaP at a median age of 68 years old (45 -90) and a median PSA of 92 ng/mL (4.4 -3463).
  • Forty-seven pts (77%) underwent prostate biopsy of which 33 (70%) had high grade (Gleason ≥ 8) tumor.
  • CONCLUSIONS: CaP initially presenting as metastatic disease is a rare event in the post-PSA era, but may result from lacking primary health care screening, poor patient compliance, or inherent predisposing factors of tumor biology.
  • Our analysis identifies a predominantly non-Caucasian population of patients, contrasting the CaPSURE database, who are otherwise healthy.
  • We plan on performing comprehensive analyses on all patients with metastatic CaP at Boston Medical Center.

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  • (PMID = 27963401.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Hayes JH, Chen M, Moran BJ, Braccioforte MH, Dosoretz D, Salenius S, Katin M, Ross R, D'Amico AV: Short-course androgen suppression therapy prior to brachytherapy for favorable-risk prostate cancer and the risk of all-cause mortality in men with or without preexisting cardiovascular disease. J Clin Oncol; 2009 May 20;27(15_suppl):5066

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The study cohort included 12,792 men with previously-untreated low or intermediate risk prostate cancer (PSA < 20 ng/mL; Gleason score 7 or below on initial biopsy; clinical category T2c or below) treated between 1992 and 2005 at one of 21 community-based medical centers in Illinois, Florida, New York, or North Carolina.
  • Multivariate Cox regression analysis was performed to assess whether significant associations between preexisting CVD and ACM existed adjusting for age, year of treatment and known prostate cancer prognostic factors.

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  • (PMID = 27964251.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Eisinger F, Morere J, Pivot X, Blay J, Coscas Y, Calazel Benque A, Roussel C, Viguier J: Trends in screening for prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):1542

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In France, there is no financial barrier for individuals to be screened with the prostate-specific antigen (PSA) test, and there is no recommendation for mass screening.
  • RESULTS: General population: In 2005, 36% of the interviewed male population aged between 50 and 75 years declared having undergone a screening test, compared to 49% in 2008 (OR = 1.63 CI<sub>95%</sub> 1.25; 2.12).
  • Prostate cancer screening increased in all age groups, however, the most significant increase can be observed in the population aged between 50 and 54 years: 18% in 2005 versus 35% in 2008 (OR = 2.43 CI<sub>95%</sub> 1.31; 4.52).

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  • (PMID = 27964078.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Kunitake H, Zheng P, Yothers G, Land S, Fehrenbacher L, Giguere JK, Wickerham DL, Ganz PA, Ko CY: Routine preventive care and cancer surveillance in long-term survivors (LTS) of colorectal cancer: Results from NSABP Protocol LTS-01. J Clin Oncol; 2009 May 20;27(15_suppl):6500

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • LTS-01 patients were more likely to have received a flu shot in the past 12 months (68% vs. 42%, p < 0.0001) and were also more likely to have undergone cancer screening by Pap smear (67% vs. 54%, p < 0.001), mammogram (85% vs. 71%, p < 0.001), and PSA test (84% vs. 75%, p < 0.001).
  • CONCLUSIONS: Long-term survivors of colorectal cancer achieve better routine preventive care including cancer screening than the general population.

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  • (PMID = 27963994.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Koolen S, Witteveen PO, Garcia-Ribas I, Callies S, Andre V, Kronemeijer RH, Nol A, Beijnen JH, Voest EE, Schellens JH: Phase I study of oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients (pts) with advanced solid tumors. J Clin Oncol; 2009 May 20;27(15_suppl):2576

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One pt with refractory prostate cancer presented a PSA CR as assessed by investigator.

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  • (PMID = 27961892.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Stein MN, Knox B, Wesolowsky E, Levitt M, Moss R, Poplin E, Mehnert J, Gounder M, Goodin S, DiPaola R: Phase I trial of patupilone (P) and RAD001 in patients (pts) with advanced solid tumors. J Clin Oncol; 2009 May 20;27(15_suppl):2529

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: A total of 24 pts have been enrolled and 23 pts are evaluable for toxicity (tumor types: colon-7, prostate-6, lung-3, ampulla-3, leiomyosarcoma-2, cervical cancer-1).
  • In pts with prostate cancer (all previously pretreated with D) PSA declines of >50% occurred in 3/5 pts treated with >2 cycles; 1/7 pts with colon cancer had a PR and 3/7 pts with colon cancer had stable disease (SD) > 8 cycles; 1/3 pts with ampullary ca had a PR and a pt with cervical ca had SD x10 cycles.
  • Encouraging evidence of clinical activity is observed in prostate, colon and other tumor types.

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  • (PMID = 27961847.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Adjei AA, Cohen RB, Kurzrock R, Gordon GS, Hangauer D, Dyster L, Fetterly G, Barrientes S, Hong DS, Naing A: Results of a phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket directed SRC inhibitor, in patients with advanced malignancies. J Clin Oncol; 2009 May 20;27(15_suppl):3511

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 3511 Background: Src kinase is central to the proliferation, apoptosis and metastasis of tumor cells.
  • KX2-391 has a much wider spectrum of solid tumor activity in vitro, and is more potent in mouse xenografts, as compared to other multikinase Src/Abl inhibitors.
  • Both the prostate and pancreatic cancer pts had dramatic decreases in their biomarkers (PSA went from 205 ng/ml to 39 ng/ml, and CA19-9 went from 38,838 U/ml to 267 U/ml, respectively).

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  • (PMID = 27961307.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Stephenson AJ, Klein EA, Kattan MW, Han M, Partin AW, Walsh PC, Trock BJ, Wood DP, Eggener SE, Eastham JA, Scardino PT: Predicting the long-term risk of prostate cancer-specific mortality after radical prostatectomy. J Clin Oncol; 2009 May 20;27(15_suppl):5007

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 5007 Background: Nomograms that predict prostate-specific antigen (PSA) defined biochemical recurrence (BCR) of prostate cancer after radical prostatectomy are the most widely used prediction tools in oncology for treatment decision making and counseling.
  • METHODS: Using Fine and Gray competing risk regression analysis, the clinical data and follow-up information of 11,521 patients treated with radical prostatectomy at four academic centers from 1987 to 2005 were modeled to predict PCSM.

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  • (PMID = 27962891.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Lo Re G, Boccalon M, Maruzzi D, Bortolus R, Lenardon O, Marus V, Rustici C, Tumolo S, Garbeglio A, Sulfaro S: A phase II noncomparative study of neoadjuvant (NA) chemohormone therapy (CHT), radical prostatectomy (RP), and postoperative radiotherapy (RT) in locally advanced (LA) high-risk prostate cancer (HRPC): A monoinstitutional 6-year experience with two NA CHT regimens. J Clin Oncol; 2009 May 20;27(15_suppl):e16091

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e16091 Background: HRPC criteria include stage T2b-T2c according to the AJCC classification, PSA ≥ 10 ng/ml, Gleason score (GS) 7-10 with 12, 6% 7-year cancer specific mortality rate (D'Amico AV, Cancer. 2006).
  • METHODS: Histological diagnosis of LA HRPC (T2b-T4), GS > 8, PSA > 10 ng/ml, age < 65 years, PS 0-1.
  • Primary endpoint: disease-free survival (DFS); secondary endpoint: PSA relapse-free survival (RFS), overall survival (OS).

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  • (PMID = 27963081.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Rademacher BL, Garzotto M, Higano CS, O'Brien CA, Janeba N, Fazli L, Lange PH, Lieberman S, Beer TM: Five-year relapse-free survival and predictors of relapse following preoperative docetaxel and mitoxantrone for high-risk localized prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):5121

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 5121 Background: Efforts to incorporate systemic therapy with activity against castration-resistant prostate cancer into the early management of high-risk disease are motivated by persistent risk of relapse when neoadjuvant androgen suppression therapy (AST) is combined with surgery.
  • As docetaxel and mitoxantrone exert anti-tumor effects through distinct cellular mechanisms, this combination has the potential for synergistic activity against prostate cancer.
  • Relapse was defined as a confirmed serum PSA > 0.4 ng/mL.
  • Serum testosterone levels remained stable after chemotherapy.
  • Pretreatment serum PSA, lymph node involvement, and post-chemotherapy tissue VEGF expression were independent predictors of early relapse.
  • Approximately half of the high risk pts remain relapse free at 5 years and clinical and molecular predictors of early relapse in this population have been identified.

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  • (PMID = 27964409.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Hatcher D, Rose AE, Christos PJ, Mazumdar M, John M, Taneja SS, Lee P, Osman I: Impact of race on survival of prostate cancer patients treated with noncurative intent. J Clin Oncol; 2009 May 20;27(15_suppl):5069

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2) no evidence of metastatic disease within 6 months after diagnosis;.
  • AA men presented with significantly higher PSA compared to CA patients (median 18.5 versus 11.4 respectively, p = 0.004), however, there were no differences in age at presentation (median 73 versus 74, p = 0.98) or Gleason score (23% of AA and CA had Gleason >7, p = 0.92).
  • Factors most predictive of mortality by Cox regression multivariable analysis were PSA at diagnosis (p = 0.001), Gleason score (p = 0.04), and age of patient at diagnosis (p < 0.0001).
  • Competing risk analysis distinguishing the types of death is underway.

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  • (PMID = 27964248.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Yuan J, Orlandi F, Jefferson M, Li H, Gallardo H, Ku G, Wolchok J, Scher H, Allison J, Slovin SF: Cytokine changes in castrate metastatic prostate cancer (CPMC) patients (pts) treated with ipilimumab (Ipi). J Clin Oncol; 2009 May 20;27(15_suppl):e16149

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We studied pts who were treated on a clinical trial with Ipi 10 mg/kg alone or with radiation to a single site in bone to determine whether there was any correlation between serum cytokine levels and autoimmune AEs.
  • METHODS: Thirteen pts were treated, of whom 10 had sufficient specimens for analysis.
  • Pts were stratified by ascertainment of clinical benefit (CB) vs. no clinical benefit (NCB) based on time-to-PSA-baseline relapse (TTBR) and also by toxicity (tox) using standard NCI tox criteria.
  • TTBR was defined as time from study entry until the time when a PSA measurement reached or exceeded the baseline value.
  • Sera at serial time points were analyzed for interferon-gamma (IFN-γ), tumor necrosis factor α and interleukins (IL)-1b, 2, 4, 8, 10, 12, 13 with the Meso Scale Discovery Multiplex Assay (MSD, Gaithersburg, MD).

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  • (PMID = 27963424.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Okihara K, Takeuchi I, Ukimura O, Takaha N, Kawauchi A, Miki T: Prognostic outcome in Japanese men with prostate cancer treated with androgen-deprivation therapy (ADT) alone: Data from multi-institutional cooperative study in Kyoto Prostate Cancer Registry (KPCR). J Clin Oncol; 2009 May 20;27(15_suppl):e16106

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clinical data including age, clinical stage, biopsy differentiation, initial prostate-specific antigen (PSA) level and type of ADT: luteinizing hormone-releasing hormone (LH-RH) monotherapy or combined androgen blockade (CAB), were analyzed.
  • Of those men, age and PSA level ranged from 52 to 95 y.o (median: 75) and from 2.17 to 8,650 ng/ml (median: 23.5), respectively.
  • Cox proportional hazards multivariate regression analyses revealed that localized cancer (stage A and B) was the most significant prognostic factor in the time to relapse (p < 0.0001) as well as the cause specific survival (p < 0.0001).

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  • (PMID = 27963336.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Granberg C, Thompson RH, Quevedo JF, Karnes RJ, Frank I, Kwon ED, Blute ML: Down-staging of locally advanced prostate cancer with anti-CTLA-4 monoclonal antibody prior to radical prostatectomy. J Clin Oncol; 2009 May 20;27(15_suppl):e16103

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To date, 5/85 patients have electively opted for off-study RP with extended pelvic lymphadenectomy after documentation of robust treatment response by PSA, staging digital rectal exam, and 3-D imaging.
  • One patient is free of disease with undetectable PSA for 19 months following adjuvant radiation treatment but no further therapy, while the other patient is awaiting follow-up.

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  • (PMID = 27963333.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Baden J, Markiewicz J, Painter J, Jones J, Curtin K, Canning S, Quijano J, Guinto W, Wang Y, Green G: Informative rate and reproducibility of the investigational GeneSearch ProCaM assay in a multicenter laboratory setting. J Clin Oncol; 2009 May 20;27(15_suppl):e22038

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e22038 Background: PSA tests have low specificity, which frequently results in unnecessary biopsy and typically limits screening to patients with PSA values >4.0 ng/mL.
  • Urine sample results for these samples showed that the areas under the curve for the 3 unique ProCaM Test Kit lots were equivalent (0.72, 0.74, 0.75, p > 0.263).

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  • (PMID = 27963156.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Bedognetti D, Rubagotti A, Conti G, Francesca F, De Cobelli O, Canclini L, Gallucci M, Aragona F, Di Tonno P, Boccardo F: An open, randomized, multicentre, phase III trial comparing the efficacy of two tamoxifen (T) schedules in preventing gynecomastia (gy) induced by bicalutamide monotherapy (BM) in prostate cancer patients (pca pts). J Clin Oncol; 2009 May 20;27(15_suppl):e16080

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We had previously demonstrated that T is safe and effective in preventing breast events induced by BM without affecting B tumor activity (Boccardo, J Clin Oncol. 2005;23:808).
  • Gy (primary endpoint), breast pain (bp), serum PSA levels and sexual functioning scores were evaluated.
  • There were no major differences among treat. schedules relative to sexual functioning scores, PSA behaviour and disease progression.
  • CONCLUSIONS: This study failed to demonstrate that it might be possible to maintain comparable prophylactic effect of T by switching from a daily to a weekly schedule and confirms that T at the daily dose of 20mg is safe and effective in preventing the incidence and severity of BM induced breast events.

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  • (PMID = 27963100.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Flechon A, Pouessel D, Ferlay C, Perol D, Beuzeboc P, Gravis G, Joly F, Oudard S, Deplanque G, Droz J, Culine S: Results of a phase II study of carboplatin and etoposide in patients with progressive metastatic castration refractory prostate cancer (mCRPC) and neuro-endocrine differentiation. J Clin Oncol; 2009 May 20;27(15_suppl):e16073

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We assessed the efficacy and toxicity of a platin-based chemotherapy regimen in patients with mCPRC and neuro-endocrine differentiation defined by: either increased circulating neuro-endocrine markers (chromogranin A: CgA, Neuron Specific Enolase: NSE) more than 1.5 X normal serum values and/or visceral metastases confirmed with immunihistochemical proof of neuro-endocrine differentiation on pathological sample.
  • METHODS: Sixty patients were included (Simon optimal two stages design with P0 = 20%, P1 = 40%, α = 5% and power 90% for a total of 54 evaluable patients) and were treated by the combination of carboplatin AUC 4 d1 IV and etoposide 100 mg/m<sup>2</sup>/d d1-3 IV every 3 weeks for a maximum of 6 cycles.
  • Efficacy endpoints included PSA and neuro-endocrine marker response rate (defined as a decrease of 50% or greater of the baseline serum value), objective response rate (according to RECIST criteria), and toxicity.
  • The PSA response rate was 9%.

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  • (PMID = 27963045.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Araujo J, Armstrong AJ, Braud EL, Posadas E, Lonberg M, Gallick GE, Trudel GC, Paliwal P, Agrawal S, Logothetis CJ: Dasatinib and docetaxel combination treatment for patients with castration-resistant progressive prostate cancer: A phase I/II study (CA180086). J Clin Oncol; 2009 May 20;27(15_suppl):5061

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Secondary endpoints were: changes in PSA, bone scans and tumor size, bone metabolism [urinary N-telopeptide (uNTX) and bone alkaline phosphatase (BAP)] and PK.
  • Preliminary analysis showed no interaction between dasatinib and D.
  • PSA response was seen in 13/32 (41%) pts, clinical benefit (PR + SD) for RECIST-evaluable pts was 21/21, [7 PR, 5 uPR and 4 SD (at ≥21 wks) and 5 SD at ≥6 wk)].

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  • (PMID = 27962978.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Kasimis B, Chang V, Gounder S, Gonzalez M, Finch-Cruz C, Blumenfrucht M, Srinivas S, Cogswell J, Morales E, Ahmed S: Prediction of survival by immunohistochemical stains (IHC) in stage D2 prostate cancer patients (pts): The importance of pTEN overexpression. J Clin Oncol; 2009 May 20;27(15_suppl):e16019

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: In an IRB approved study,42 pts had adequate tissue preserved between 1992 and 2006 and their charts were reviewed retrospectively.IHC stains to detect tumor expression of S6(ribosomal),p70s6,pTEN,AKT-1,BCL-1(Cyclin D1),VEGF,c-KIT,PDGFR-alpha and PDGFR-beta were performed by US Labs(Irvine,CA).All results were independently evaluated by two pathologists.Immunoreactivity was scored using a semiquantitative system combining intensity of staining(0-3+) and percentage of cells staining positive(0-3+).The total score was obtained by adding the scores for indensity and the percentage of positive cells,then averaging the resuts obtained by each reader.For the purpose of this study, stain intensity of 0-1+ was considered negative and the intensity of 2-3+ was considered positive.A Cox regression survival model for each stain was developed with variables known to predict survival :Gleason score,Hemoglobin(Hgb),Alkaline Phosphatase(Alk Phos),Prostate Specific Antigen(PSA),Lactate Dehydrogenase(LDH) levels.
  • RESULTS: The median values were: age 70yrs(56-92),Gleason score 8(6-10), LDH 171 IU/L(97-350),Hgb 12.9gm/dl (6.8-16.3), PSA 188ng/ml(2-5677),Alk Phos 139U/L(60-1756),survival 851 days(163- 6102).In univariate analysis,VEGF staining was predictive of survival (p<0.037) but not in multivariate analysis.The pTEN staining correlated with survival (p<0.0367) and a hazard ratio of 0.040 in multivariate analysis.
  • CONCLUSIONS: In this small sample of pts, overexpression of S6,p70s6,AKT-1,BCL-1,VEGF,c-KIT,PDGFR-alpha and PDGFR-beta by IHC staining did not predict survival independently.The pTEN staining,however was strong predictor of survival in the multivariate analysis.

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  • (PMID = 27962908.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Sinibaldi VJ, Carducci MA, Moore-Cooper S, George B, Denmeade S, Drake CG, Walczak J, Pili R, Zahurak ML, Eisenberger MA: A randomized double blind phase I-II study to determine the tolerability/efficacy of two different doses of lenalidomide (L), CC- 5013, in biochemically relapsed (BR) prostate cancer (PC) patients (pts) (M&lt;sub&gt;0&lt;/sub&gt;) after local treatment (LT). J Clin Oncol; 2009 May 20;27(15_suppl):5130

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eligible pts had: rising PSA (≥1 ng/mL), M<sub>0</sub> disease, testosterone > 150 ng/mL, adequate bone marrow, renal, and hepatic function.
  • Baseline and Q 2 mos PSA's were processed after Q 6 mos of L, along with CT and bone scan.
  • Primary endpoints are safety and progression after 6 mo of L (defined by a confirmed ↑ in PSA > 25% over the baseline value or mets).
  • Secondary endpoints are changes of slopes in PSA related to pharmacokinetics (pk).
  • A sample size of 30 pts/arm provides an 85% power to detect a PSA progression rate of 40% (compared to 80% predicted ) with a Type I error = 0.05 (Fishers exact test).
  • Pooled data from the 2 arms: median: age 64 (50-81), ECOG PS 0, baseline PSA 9.3 ng/ml (1.3-92.8 ng/ml).
  • Of 44 pts, blinded evaluation of PSA's at 6 mos: 4 pts had ≥ 50% ↓, 22 had stable PSA,17 had PD, 1 too early .
  • CONCLUSIONS: Preliminary data prior to unblinding the study treatment arms, from pooled data, suggest that L may be administered > 6 mos with acceptable toxicity, and is associated with PSA declines and long term stabilization in pts with BR.

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  • (PMID = 27964411.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Antonarakis ES, Trock BJ, Feng Z, Humphreys EB, Carducci MA, Partin AW, Walsh PC, Eisenberger MA: The natural history of metastatic progression in men with PSA-recurrent prostate cancer after radical prostatectomy: 25-year follow-up. J Clin Oncol; 2009 May 20;27(15_suppl):5008

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The natural history of metastatic progression in men with PSA-recurrent prostate cancer after radical prostatectomy: 25-year follow-up.
  • : 5008 Background: In men with prostate specific antigen (PSA) recurrence following radical prostatectomy (RP) and no other therapy, the natural history of metastatic progression was previously described in 1999.
  • METHODS: We performed a retrospective analysis of 774 men treated with RP between 4/1982 and 7/2008 who developed PSA recurrence (>0.2 ng/ml) and never received adjuvant or salvage therapy.
  • Of 774 men with PSA recurrence, 295 (38%) developed metastases, and 433 had data on PSA doubling time (PSADT), forming our cohort.
  • The mean time from RP to PSA recurrence in the entire cohort was 4.2 y (median 3 y).
  • In those who developed metastases, the mean time from PSA recurrence to metastasis was 3.1 y (median 2 y).
  • The mean PSA at the time of metastasis was 90.3 ng/ml (median 31.4 ng/ml).
  • In Cox regression analysis: PSADT, Gleason score, and time to PSA progression were predictive of the development of metastases ( Table ).
  • In Kaplan-Meier survival analysis, the median actuarial time from PSA recurrence to metastasis was 10 y (95% CI 9 - 15 y).
  • Median actuarial metastasis-free survival from PSA recurrence for men with PSADT <3 mo, 3 - 8.9 mo, 9 - 14.9 mo, and >15 mo was 1 y (95% CI 0 - 1 y), 4 y (95% CI 2 - 6 y), 9 y (95% CI 7 - 13 y), and 15 y (95% CI 12 - 20 y), respectively.
  • CONCLUSIONS: PSADT, Gleason score, and time to PSA progression are strong independent predictors of metastasis-free survival in men with PSA-recurrent prostate cancer.

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  • (PMID = 27962890.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Poiesz B, Reeves J, McNulty W, Maleski J, Holmlund J, Leopold L: Preliminary report of an open-label, multicenter, phase I/II study of AT-101 in combination with docetaxel (D) and prednisone (P) in men with docetaxel refractory prostate cancer. J Clin Oncol; 2009 May 20;27(15_suppl):5145

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AT-101 is active as a single agent and in combinations with standard therapies in in vitro and in vivo tumor models, as a single agent in a phase II trial in CRPC, and in combination with D/P as first-line therapy in CRPC, as demonstrated by declines in PSA and RECIST responses.
  • Patients (pts) must have PSA progression per the Bubley criteria or documented disease progression while receiving prior D/P therapy.
  • Safety (NCI CTCAE v3.0) and efficacy (Bubley Criteria for PSA) were assessed at 3-wk intervals.
  • Thirty-five percent (12/34) of pts treated had at least a 30% decrease in PSA level and 18% (6/34) of pts achieved a >50% PSA decline.
  • Twenty one of 34 pts included in this analysis had measurable disease.
  • Five pts (24%) with measurable disease had a PR or CR by RECIST criteria and one additional patient had tumor shrinkage of 29%.
  • Durable PSA and RECIST responses were observed.

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  • (PMID = 27964445.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Kantoff PW, Schuetz T, Blumenstein BA, Glode MM, Bilhartz D, Gulley J, Schlom J, Laus R, Godfrey W: Overall survival (OS) analysis of a phase II randomized controlled trial (RCT) of a poxviral-based PSA targeted immunotherapy in metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol; 2009 May 20;27(15_suppl):5013

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overall survival (OS) analysis of a phase II randomized controlled trial (RCT) of a poxviral-based PSA targeted immunotherapy in metastatic castration-resistant prostate cancer (mCRPC).
  • PROSTVAC-VF (PV) comprises 2 recombinant viral vectors (Vaccinia and Fowlpox), each encoding transgenes for prostate specific antigen (PSA) and 3 immune costimulatory molecules (B7.1, ICAM-1, and LFA3: TRICOM).
  • Eligible pts had metastatic disease, a rising PSA despite castrate testosterone levels, and a Gleason score of ≤7.
  • Pt characteristics were similar (means): age (72PV/76C), PSA (134PV/188C), Alk-Phos (142PV/159C), LDH (207PV/218C), Hgb (13PV/13C), and number bone metastatic sites (5.3PV/6.5C).
  • These data provide evidence of prolonged anti-tumor activity, but need to be confirmed in a larger phase III study.

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  • (PMID = 27962903.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Luu T, Sartor O, Dandade N, Halabi S, Bennett C: Comparability of health-related quality of life (HRQOL), treatment decision making, and treatment satisfaction after PSA recurrence among prostate cancer patients who receive hormone therapy (HT) versus observation (OBS): Results from the COMPARE registry. J Clin Oncol; 2009 May 20;27(15_suppl):5131

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparability of health-related quality of life (HRQOL), treatment decision making, and treatment satisfaction after PSA recurrence among prostate cancer patients who receive hormone therapy (HT) versus observation (OBS): Results from the COMPARE registry.
  • : 5131 Background: HT may lower PSA, but it may also cause hot flashes and sexual dysfunction.
  • OBS is not associated with hot flashes or lower testosterone production, but PSA may rise.
  • METHODS: The Comprehensive Multicenter Prostate Adenocarcinoma Registry (COMPARE) is an observational registry of men with PSA failure.
  • The median time between cancer diagnosis and registry enrollment was 6 years.
  • CONCLUSIONS: Men with PSA failure seem content with treatment choice and decision making and have low rates of urinary/bowel problems.

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  • (PMID = 27964431.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Donato Di Paola E, Alonso S, D'Alessio A, Giuliani R, Calabrò F, Messina C, Zivi A, Squilloni E, De Marco S, Sternberg C: Dose finding study of the combination of satraplatin and gemcitabine in patients with advanced solid tumors. J Clin Oncol; 2009 May 20;27(15_suppl):e13534

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2 pts had PSA declines, with TTP of 630 days in 1 of them.

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  • (PMID = 27961340.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Hotte SJ, Yu EY, Hirte HW, Higano CS, Gleave M, Chi KN: OGX-427, a 2'methoxyethyl antisense oligonucleotide (ASO), against HSP27: Results of a first-in-human trial. J Clin Oncol; 2009 May 20;27(15_suppl):3506

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Circulating tumor cells (CTC), Hsp27+ CTC and serum Hsp27 levels were evaluated serially.
  • Three pts with prostate ca had PSA declines of 43%, 58%, 62% and 3 pts with ovarian cancer had CA-125 declines of 27%, 28%, and 41%.
  • Changes in tumor markers suggest single-agent activity.

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  • (PMID = 27961276.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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