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1. Ekici AI, Ekici S, Gürel B, Altinok G, Erkan I, Güngen Y: Benign mixed epithelial and stromal tumor of the kidney. ScientificWorldJournal; 2006;6:615-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign mixed epithelial and stromal tumor of the kidney.
  • The renal mass was found to be a benign, biphasic tumor composed of an epithelial component, consisting of ducts of variable size scattered within a mesenchymal component, composed of spindle cells arranged in sheets and fascicles.
  • The diagnosis of benign mixed epithelial and stromal tumor of the kidney is rendered.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Nephroma, Mesoblastic / pathology
  • [MeSH-minor] Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Middle Aged. Nephrectomy. Stromal Cells / pathology

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  • (PMID = 16752009.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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2. Huang YJ, Huang X, Shi XY, Lu J: [Pathological characteristics mixed epithelial and stromal tumor of kidney]. Beijing Da Xue Xue Bao; 2008 Aug 18;40(4):415-8
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  • [Title] [Pathological characteristics mixed epithelial and stromal tumor of kidney].
  • OBJECTIVE: To study the clinicopathological features of mixed epithelial and stromal tumor of the kidney(MESTK).
  • Radiology revealed a large cystic/solid mass within the right kidney.
  • Microscopically, the tumor was composed of a mixture of stromal and epithelial components.
  • The epithelial component was composed of flat to columnar cells forming glands or tubules.
  • The stromal components essentially consisted of bland, loosely packed spindle cells in an edematous and myxoid background.
  • Immunohistochemical staining revealed that the epithelial components were positive for AE1/AE3 and focally positive for estrogen receptor (ER),progesterone receptor(PR), CD10 and Vimentin, whereas the stromal components were positive for ER, PR, Desmin and smooth muscle actin(SMA).
  • Both epithelial and stromal components were negative for HMB-45, S-100, alpha-inhibin and WT-T.
  • CONCLUSION; MESTK occurred in a pubertal male, as in the current case, supports the hypothesis that proliferation of remnants of the primitive mesenchyme in the kidney in situation of sex-steroid abnormity may play an important role in the pathogenesis of male MESTK.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 18677391.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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3. Terao H, Makiyama K, Yanagisawa M, Miyake M, Sano F, Kita K, Murakami T, Nakaigawa N, Ogawa T, Uemura H, Yao M, Kubota Y, Inayama Y, Nagashima Y: [Mixed epithelial and stromal tumor of kidney: a case report]. Hinyokika Kiyo; 2009 Aug;55(8):495-8
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  • [Title] [Mixed epithelial and stromal tumor of kidney: a case report].
  • Mixed epithelial and stromal tumor of kidney (MEST-K) is a rare benign renal tumor that was first described by Michal and Syrucek in 1998.
  • Here, we report an additional case of MEST-K occurring in a 28-year-old woman.
  • The computed tomography revealed hydronephrosis and a cystic tumor in the right kidney, and laparoscopic right nephrectomy was performed.
  • The resected kidney contained a cystic lesion with a grayish-white mural nodule, in the lower portion.
  • Based on these findings, the tumor was diagnosed as MEST-K.
  • MEST-K was newly introduced to the WHO classification of renal tumors, with a pathogenesis related to long-term estrogen exposure, because of ER and PR expression in the stroma.
  • It is important to consider the possibility of this tumor when encountering cases of cystic tumor in middle-aged and older women, and men with a previous history of estrogen administration.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 19764536.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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4. Xiang H, Ding W, Liu F, Ren GP, Wang ZM, Zhu XZ: [Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma]. Zhonghua Bing Li Xue Za Zhi; 2009 Jul;38(7):436-40
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  • [Title] [Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma].
  • OBJECTIVE: To study the clinicopathologic features, immunophenotype and differential diagnosis of mixed epithelial and stromal tumor of kidney (MEST) and adult cystic nephroma (CN).
  • METHODS: Five cases of MEST and 4 cases of CN were retrospectively analyzed.
  • RESULTS: All of the five patients with MEST were females.
  • On gross examination, MEST was well-circumscribed but non-encapsulated.
  • Histologically, MEST consisted of proliferation of cystically dilated glands admixed with spindly stromal cells with various cellularity and growth patterns.
  • Both the glandular and stromal elements were well-differentiated with no cytologic atypia identified.
  • In contrast, the thin-walled cystic spaces in CN were lined by a single layer of epithelium.Immunohistochemical study showed that the epithelial cells were positive for pan-cytokeratin and epithelial membrane antigen.
  • The spindle cells in MEST expressed vimentin (5/5), smooth muscle actin (3/5), desmin (4/5), CD10 (5/5), estrogen receptor (4/5) and progesterone receptor (4/5).
  • CONCLUSIONS: Both MEST and CN are uncommon renal neoplasm.
  • Most of them run a benign clinical course.
  • The stromal cells in MEST show smooth muscle or myofibroblastic differentiation.
  • MEST and CN share overlapping histological and immunohistochemical features, and may represent spectrum of the same group of lesions.
  • [MeSH-major] Epithelial Cells / pathology. Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Stromal Cells / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Carcinoma, Renal Cell / pathology. Desmin / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Nephroma, Mesoblastic / pathology. Receptors, Estrogen / metabolism. Retrospective Studies. Vimentin / metabolism

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  • (PMID = 19781188.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Desmin; 0 / Receptors, Estrogen; 0 / Vimentin
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5. Yang Y, Nie X, Lu J, Lu XY, Wei YY, Wang H, Han ZH, Chen ZH, Zheng J: [Mixed epithelial and stromal tumor of kidney]. Zhonghua Bing Li Xue Za Zhi; 2006 Jan;35(1):29-31
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  • [Title] [Mixed epithelial and stromal tumor of kidney].
  • OBJECTIVE: To study the clinicopathological features and differential diagnoses of mixed epithelial and stromal tumor of the kidney.
  • METHODS: Clinical and pathological characteristics of 4 cases of mixed epithelial and stromal tumor of the kidney were studied.
  • Radiologic studies revealed cystic and solid masses involving the kidney.
  • Microscopically, the tumors were composed of a mixture of stromal and epithelial elements.
  • The epithelial elements were variable in cell types including cuboidal, hobnail and columnar cells.
  • One case showed Müllerian and intestinal epithelial differentiations.
  • Stromal elements essentially consisted of spindle cells, with thick-walled blood vessels and bands of smooth muscle cells as distinctive features of the tumor.
  • Immunohistochemical staining revealed that the epithelial components were positive for AE1/AE3, whereas the stromal components were positive for ER, PR, and SMA.
  • CONCLUSIONS: Mixed epithelial and stromal tumor of the kidney is a benign neoplasm with distinct histopathological features.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Muscle, Smooth / metabolism. Nephrectomy / methods. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 16608646.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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6. Compérat E, Couturier J, Peyromaure M, Cornud F, Vieillefond A: Benign mixed epithelial and stromal tumor of the kidney (MEST) with cytogenetic alteration. Pathol Res Pract; 2005;200(11-12):865-7
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  • [Title] Benign mixed epithelial and stromal tumor of the kidney (MEST) with cytogenetic alteration.
  • Benign mixed epithelial and stromal tumor of the kidney (MEST) is a new, rare entity.
  • These tumors are composed of two components: a stromal and an epithelial one.
  • [MeSH-major] Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology. Translocation, Genetic
  • [MeSH-minor] Actins / analysis. Adult. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Cysts / pathology. Desmin / analysis. Diagnosis, Differential. Humans. Keratins / analysis. Male. Nephrectomy. Stromal Cells / chemistry. Stromal Cells / pathology

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  • (PMID = 15792135.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 68238-35-7 / Keratins
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7. Compérat E, Camparo P, Vieillefond A: [WHO classification 2004: tumors of the kidneys]. J Radiol; 2006 Sep;87(9):1015-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • New entities, confirmed either by cytogenetic findings or by new molecular markers, have been included in the WHO 2004 renal tumor classification.
  • We will especially insist on the following entities: multilocular clear cell renal carcinoma, Xp11 translocation carcinoma, low-grade mucinous tubular carcinoma, epithelioid angiomyolipoma, and benign mixed epithelial and stromal tumor.
  • We also discuss the new concept of hybrid oncocytoma and chromophobe renal cell carcinoma, as well as the Birt-Hogg-Dube syndrome, which is associated with kidney tumors.
  • [MeSH-major] International Classification of Diseases. Kidney Neoplasms / classification. Kidney Neoplasms / pathology

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  • (PMID = 16936625.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 21
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8. Moslemi MK: Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update. Urol J; 2010;7(3):141-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update.
  • PURPOSE: Our aim was to review the spectrum of usual and unusual clinical and morphologic findings observed in mixed epithelial and stromal tumor of the kidney (MEST).
  • MATERIALS AND METHODS: On the basis of MEDLINE database searches, we assessed all aspects of MEST or adult mesoblastic nephroma since the first report in 1997 till the end of 2009.
  • RESULTS: Mixed epithelial and stromal tumor is a relatively rare and distinct neoplasm of the kidney that should be distinguished from other renal neoplasms.
  • Although the overall prognosis is favorable, recurrence and malignant transformation of MEST can occur CONCLUSION: It is difficult to distinguish benign or malignant nature on imaging studies.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Nephroma, Mesoblastic / diagnosis


9. Park HS, Kim SH, Kim SH, Paik JH, Hwang SI, Jung SI, Choi YH: Benign mixed epithelial and stromal tumor of the kidney: imaging findings. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):786-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign mixed epithelial and stromal tumor of the kidney: imaging findings.
  • Three cases of mixed epithelial and stromal tumor of the kidney with their imaging findings are described; these cases have not been reported previously in the radiology literature.
  • This benign tumor contains epithelial and spindle cell stromal components and arises exclusively in adult women.
  • [MeSH-major] Kidney / pathology. Kidney / radiography. Kidney Neoplasms / diagnosis. Neoplasms, Complex and Mixed / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis. Stromal Cells / pathology
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Rare Diseases. Tomography, X-Ray Computed / methods

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  • (PMID = 16272852.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Chu PG, Lau SK, Weiss LM, Jiang Z: Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney. Virchows Arch; 2009 Oct;455(4):389-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney.
  • We report a mucinous borderline tumor arising from a mixed epithelial and stromal tumor of left kidney (MESTK).
  • The patient had a cytoscopy with a retrograde pyelogram, which indicated a dilated left kidney with a central mass lesion.
  • Cross-sections of left kidney showed a 4.5 x 3.5 x 1.5 cm ill-defined cystic lesion with mucinous and solid areas.
  • In areas, the mucinous epithelium showed complex proliferation with stratification, papillae formation, and nuclear atypia, resembling that of an ovarian mucinous borderline tumor, a colorectal tubular adenoma, or a low-grade appendiceal mucinous carcinoma.
  • Immunohistochemically, the mucinous borderline tumor showed a colorectal phenotype, being strongly positive for CK20, CDX-2, and MUC2.
  • There was no invasive mucinous tumor identified.
  • We believe that this case represents the first reported example of mucinous borderline tumor arising from a MESTK.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 19756727.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Colombo P, Naspro R, Vallieri L, Vavassori I, Valenti S, Galli C, Roncalli M: Non-hormone-induced mixed epithelial and stromal tumor of kidney in a man: description of a rare case. Urology; 2008 Jan;71(1):168.e7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-hormone-induced mixed epithelial and stromal tumor of kidney in a man: description of a rare case.
  • Mixed epithelial and stromal tumor of the kidney is a recently recognized category of lesions occurring mostly in adult, middle-age women with a history of hormonal treatment.
  • We present a rare case of a 58-year-old asymptomatic man without a history of hormonal treatment with a tumor characterized by proliferation of multiple cysts lined by single layers of epithelial cells and hypercellular stroma of spindle "ovarian-like" cells.
  • Immunohistochemically, the stromal cells reacted against estrogen and progesterone receptors, vimentin, desmin, and CD34.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis. Stromal Cells / pathology

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  • (PMID = 18242391.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Desmin
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12. Jung SJ, Shen SS, Tran T, Jun SY, Truong L, Ayala AG, Ro JY: Mixed epithelial and stromal tumor of kidney with malignant transformation: report of two cases and review of literature. Hum Pathol; 2008 Mar;39(3):463-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed epithelial and stromal tumor of kidney with malignant transformation: report of two cases and review of literature.
  • We present 2 cases of mixed epithelial and stromal tumor of the kidney with sarcomatous transformation.
  • The resected tumor involved the right renal parenchyma, measuring 13.0 x 8.0 x 4.0 cm, and extended to perirenal adipose tissue.
  • The tumor measured 6.0 x 5.5 x 4.0 cm, with an intact capsule at the upper pole.
  • Sections of both tumors revealed benign and malignant components.
  • The benign component consisted of multilocular cysts and fibrous stroma with a focally ovarian stromalike component.
  • We report 2 additional cases of sarcomatous transformation in mixed epithelial and stromal tumor of the kidney.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma / metabolism. Carcinoma / pathology. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Middle Aged. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 18261632.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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13. Mukhopadhyay S, Valente AL, de la Roza G: Corpora albicantia-like bodies in cystic nephroma: yet another similarity to mixed epithelial stromal tumor of kidney. Int J Surg Pathol; 2005 Apr;13(2):233
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Corpora albicantia-like bodies in cystic nephroma: yet another similarity to mixed epithelial stromal tumor of kidney.
  • [MeSH-major] Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology
  • [MeSH-minor] Cicatrix / pathology. Corpus Luteum / pathology. Female. Humans. Neoplasms, Glandular and Epithelial / pathology

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  • [CommentOn] Int J Surg Pathol. 2004 Jul;12(3):298 [15306946.001]
  • (PMID = 15864392.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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14. Turbiner J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishnan A, Oliva E: Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol; 2007 Apr;31(4):489-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term.
  • Cystic nephroma (CN) and mixed epithelial and stromal tumor (MEST) are rare benign renal neoplasms that have overlapping clinical and morphologic features, including predominance in middle-aged women, variably cystic architecture, eosinophilic cells, and hobnail cells lining the cysts and ovarian-type stroma.
  • Histologically, all tumors were well-circumscribed except for one MEST.
  • The stromal/epithelial ratio was approximately 2.3 in MESTs versus 0.3 in CNs; cellular ovarian-type stroma composed 45% of the stroma in MESTs and 12% of the stroma of CNs.
  • Stromal hyalinization was prominent in both.
  • Five MESTs showed stromal luteinization.
  • In the epithelial component, the relative amount of large cysts, medium to small cysts, and phyllodes-type glands was: 65%/25%/10% in CNs versus 25%/40%/35% in MESTs.
  • The epithelial component ranged from flat to cuboidal to hobnail cells in both types of tumors.
  • No significant atypia of either component was seen, although the epithelial cells showed reactive changes.
  • Immunohistochemical stains for estrogen receptors and progesterone receptors showed 62% and 85% positivity in the stromal component of MESTs versus 19% and 40% in CNs.
  • Follow-up in both categories of tumors (mean 3.2 y, median 3 y for CNs and mean 2.5 y, median of 2 y for MESTs) showed no evidence of recurrence or metastases in keeping with their benign nature.
  • This study highlights the remarkable similarity between CN and MEST in sex predilection, age distribution, and morphologic attributes of both the epithelial and stromal components and immunohistochemical profile albeit with variation in individual categories with higher prevalence of stromal to epithelial ratio, prominent ovarian stroma, smaller cysts with phyllodes glands pattern and stromal luteinization being more common in MEST; and large cysts, thin septae and low stromal to epithelial ratio in CN.
  • On the basis of detailed morphologic analysis of this series of CN and MEST, we propose a unifying term of "renal epithelial and stromal tumor" (REST) to encompass the spectrum of findings observed in these tumors at least until new molecular studies can prove or disprove this challenging hypothesis.
  • [MeSH-major] Kidney Neoplasms / classification. Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / classification. Neoplasms, Glandular and Epithelial / pathology. Nephroma, Mesoblastic / classification. Nephroma, Mesoblastic / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 17414095.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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15. Cheng L, Yang YP, Zhang SB, Zhu YL, Zhang JM: [Cystic nephroma and mixed epithelial stromal tumor of kidney: evolution of terminology, controversies, pathologic features and differential diagnosis]. Zhonghua Bing Li Xue Za Zhi; 2008 Oct;37(10):707-10
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  • [Title] [Cystic nephroma and mixed epithelial stromal tumor of kidney: evolution of terminology, controversies, pathologic features and differential diagnosis].
  • [MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Nephroma, Mesoblastic / diagnosis. Nephroma, Mesoblastic / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Kidney / pathology

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  • (PMID = 19094493.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Lectures
  • [Publication-country] China
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16. Compérat EV, Vasiliu V, Ferlicot S, Camparo P, Sibony M, Vieillefond A: [Tumors of the kidneys: new entities]. Ann Pathol; 2005 Apr;25(2):117-33
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  • Since 1998 new entities have surfaced in renal tumor classification and have been included in the WHO 2004 classification.
  • In this article, we will discuss the following entities: multilocular clear cell renal carcinoma, Xp11 translocation carcinoma, low grade mucinous tubular carcinoma, epithelioid angiomyolipoma, benign mixed epithelial and stromal tumor.
  • We will investigate new concepts of hybrid oncocytoma and chromophobe renal cell carcinoma and the syndrome of Birt-Hogg-Dube which is associated to kidney tumors.
  • [MeSH-major] Kidney Neoplasms / classification. Kidney Neoplasms / pathology

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  • (PMID = 16142163.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 77
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17. Picken MM, Fresco R: Mixed epithelial and stromal tumor of the kidney: preliminary immunohistochemical and electron microscopic studies of the epithelial component. Ultrastruct Pathol; 2005 May-Aug;29(3-4):283-6
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  • [Title] Mixed epithelial and stromal tumor of the kidney: preliminary immunohistochemical and electron microscopic studies of the epithelial component.
  • Mixed epithelial and stromal tumor of the kidney is a rare biphasic tumor composed of cysts and tubules embedded in the spindle cell stroma.
  • Although the histogenesis of this tumor is unknown, it has been proposed that both components of the tumor, i.e., stromal and epithelial, are neoplastic.
  • The authors report preliminary immunohistochemical and electron microscopic studies of the epithelial component from one case of a typical, benign, mixed epithelial, and stromal tumor of the kidney.
  • The authors believe that in a benign tumor such morphologic heterogeneity is inconsistent with neoplastic proliferation.
  • Therefore, they postulate that in mixed epithelial and stromal tumor of the kidney the tubules are entrapped rather than neoplastic.
  • [MeSH-major] Epithelial Cells / pathology. Kidney Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis. Microscopy, Electron. Neprilysin / analysis

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  • (PMID = 16036882.001).
  • [ISSN] 0191-3123
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / Keratin-7; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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18. Michal M, Hes O, Nemcova J, Sima R, Kuroda N, Bulimbasic S, Franco M, Sakaida N, Danis D, Kazakov DV, Ohe C, Hora M: Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity. Virchows Arch; 2009 Jan;454(1):89-99
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  • [Title] Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity.
  • We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT).
  • The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma.
  • Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts.
  • The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases.
  • RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers / metabolism. Epithelial Cells / pathology. Female. Humans. Keratin-20 / metabolism. Keratin-7 / metabolism. Keratins / metabolism. Loss of Heterozygosity. Male. Middle Aged. Mucin-1 / metabolism. Mutation. Vimentin / metabolism. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • [CommentIn] Virchows Arch. 2009 Apr;454(4):479-80 [19205727.001]
  • [Cites] Radiology. 1983 Feb;146(2):309-21 [6294736.001]
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  • (PMID = 19020896.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / Keratin-20; 0 / Keratin-7; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins; EC 2.3.2.27 / Von Hippel-Lindau Tumor Suppressor Protein; EC 6.3.2.- / VHL protein, human
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19. Lang N, Li J, Liu JY, Zeng XZ, Yang Y: Mixed epithelial and stromal tumor of the kidney: an analysis of multidetector computed tomography manifestations and clinicopathologic findings. J Comput Assist Tomogr; 2010 Mar-Apr;34(2):177-81
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  • [Title] Mixed epithelial and stromal tumor of the kidney: an analysis of multidetector computed tomography manifestations and clinicopathologic findings.
  • OBJECTIVES: To explore the features of mixed epithelial and stromal tumor of kidney (MESTK) on the images of multidetector computed tomography with clinical manifestations and pathological findings as a reference.
  • One tumor processed to renal pelvis, 1 protruded from the cortex, and 4 large masses processed to both the cortex and the pelvis.
  • CONCLUSIONS: Radiologists should consider the possibility of MESTK when they find that the tumor is a single solid or a cystic solid mass, especially in a female patient, and that the solid components present a mild-to-moderate enhancement during the corticomedullary phase and delayed enhancement, but the definite diagnosis depends on pathology.
  • [MeSH-major] Kidney Neoplasms / radiography. Neoplasms, Glandular and Epithelial / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Retrospective Studies. Stromal Cells / pathology

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  • (PMID = 20351499.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Richter M, Meyer W, Küster J, Middel P: Exophytic benign mixed epithelial stromal tumour of the kidney: case report of a rare tumour entity. Diagn Pathol; 2010;5:16
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  • [Title] Exophytic benign mixed epithelial stromal tumour of the kidney: case report of a rare tumour entity.
  • BACKGROUND: Mixed epithelial and stromal tumour (MEST) represents a recently described benign composite neoplasm of the kidney, which predominantly affects perimenopausal females.
  • Most tumours are benign, although rare malignant cases have been observed.
  • A CT scan of the abdomen showed a 30-mm-in-diameter uniform mass adjacent to the pelvis of the left kidney.
  • Surgical exploration showed a tumour arising from the lower anterior hilus of the left kidney.
  • The tumour could be excised by preserving the kidney.
  • By intraoperative frozen section the tumour showed characteristic features of MEST with epithelial-covered cysts embedded in an "ovarian-like" stroma.
  • Additional immunohistochemistry investigations showed expression for hormone receptors by the stromal component of the tumour.
  • DISCUSSION: MEST typically presents in perimenopausal women as a primarily cystic mass.
  • Commonly, the tumour arises from the renal parenchyma or pelvis.
  • The tumour is composed of an admixture of cystic and sometimes more solid areas.
  • The stromal cells typically demonstrate an ovarian-type stroma showing expression for the estrogen and progesterone receptors.
  • CONCLUSION: MEST represents a distinctive benign tumour entity of the kidney, which affects perimenopausal woman.
  • The tumour should be distinguished from other cystic renal neoplasms.
  • By imaging studies it is difficult to distinguish between a benign or malignant nature of the tumour.
  • [MeSH-major] Epithelial Cells / pathology. Kidney Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Stromal Cells / pathology

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  • [Cites] Ultrastruct Pathol. 2005 May-Aug;29(3-4):283-6 [16036882.001]
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  • [Cites] J Urol. 2001 Oct;166(4):1381-2 [11547080.001]
  • [Cites] Virchows Arch. 2001 Nov;439(5):700-2 [11764393.001]
  • [Cites] Histopathology. 2004 Mar;44(3):302-4 [14987239.001]
  • [Cites] Virchows Arch. 2004 Oct;445(4):359-67 [15322873.001]
  • [Cites] Semin Diagn Pathol. 1998 Feb;15(1):2-20 [9503503.001]
  • [Cites] Pathol Res Pract. 1998;194(6):445-8 [9689654.001]
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  • (PMID = 20193076.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2842239
  • [General-notes] NLM/ Original DateCompleted: 20100609
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21. Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, Ezaki O, Ogawa Y: Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. FEBS Lett; 2007 Jan 9;581(1):91-6
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.
  • Paternally expressed 1 (Peg1)/mesoderm specific transcript (Mest) is an imprinted gene, which is only transcribed from the paternal (father's) allele.
  • In some human cancer tissues, an alternatively spliced variant of PEG1/MEST mRNA using a different promoter of a distinct first exon is expressed from both paternal and maternal alleles.
  • We previously reported that Peg1/Mest expression was markedly up-regulated in obese adipose tissue in mice.
  • Moreover, transgenic overexpression of Peg1/Mest in the adipose tissue resulted in the enlargement of adipocytes in size.
  • Given the potential pathophysiologic relevance in obesity, we examined the nature of increased expression of Peg1/Mest in obese adipose tissue.
  • In obese adipose tissue, expression of Peg1/Mest was increased, but not that of other imprinted genes tested.
  • The transcription rate of Peg1/Mest was increased in obese adipose tissue.
  • We found at least four isoforms of mouse Peg1/Mest generated by use of the alternative first exons.
  • We also demonstrated that the abundantly expressed Peg1/Mest in obese adipose tissue retained monoallelic expression.
  • This is the first report of monoallelic induction of Peg1/Mest in adult tissues.

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  • (PMID = 17182038.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Proteins; 0 / mesoderm specific transcript protein
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22. Hahn Y, Yang SK, Chung JH: Structure and expression of the zebrafish mest gene, an ortholog of mammalian imprinted gene PEG1/MEST. Biochim Biophys Acta; 2005 Nov 10;1731(2):125-32
ZFIN. ZFIN .

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  • [Title] Structure and expression of the zebrafish mest gene, an ortholog of mammalian imprinted gene PEG1/MEST.
  • PEG1/MEST is a paternally expressed gene in placental mammals.
  • Here, we report identification of zebrafish (Danio rerio) gene mest, an ortholog of mammalian PEG1/MEST.
  • Zebrafish mest encodes a polypeptide of 344 amino acids and shows a significant similarity to mammalian orthologs.
  • Zebrafish mest is present as a single copy in the zebrafish genome and is closely linked to copg2 as in mammals.
  • It is notable that 10 of 11 intron positions in mest are conserved among mammalian PEG1/MEST genes, indicating that the genomic organization and linkage between mest and copg2 loci was established in ancient vertebrates.
  • Zebrafish mest is expressed in blastula, segmentation, and larval stages, exhibiting gradually increased expression as the development proceeds.

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  • (PMID = 16263186.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Codon; 0 / DNA, Complementary; 0 / Proteins; 0 / mesoderm specific transcript protein
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23. Lane BR, Campbell SC, Remer EM, Fergany AF, Williams SB, Novick AC, Weight CJ, Magi-Galluzzi C, Zhou M: Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. Urology; 2008 Jun;71(6):1142-8
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  • [Title] Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics.
  • OBJECTIVES: Adult cystic nephroma (CN) and mixed epithelial and stromal tumor (MEST) are benign renal tumors readily distinguished from cystic renal cell carcinoma and other malignant variants based on histopathology.
  • Clinical and radiographic data regarding these lesions are sparse, especially with respect to factors providing clinical suspicion for CN or MEST.
  • METHODS: Pathology of 22 CN (21 patients) and 10 MEST (9 patients) treated between 1987 and 2005 was re-reviewed according to 2004 WHO classification.
  • RESULTS: Nineteen CN patients (90%) and 9 MEST patients (100%) were female and median ages were 55 (range: 39 to 79) and 52 (range: 39 to 67) years, respectively.
  • CN were commonly Bosniak III lesions (77%), whereas 70% of MEST had solid enhancing components.
  • An intrapelvic component was present in 5 CN (23%) and no MEST.
  • Preoperative radiologic suspicion was documented in 36% of CN, but in only 1 patient with MEST.
  • There was 1 case each of bilateral CN and MEST.
  • One patient with MEST had sarcomatous component.
  • CONCLUSIONS: CN and MEST typically present symptomatically in perimenopausal women.
  • [MeSH-major] Kidney Neoplasms / pathology. Kidney Neoplasms / radiography
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 18313107.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Poplinski A, Tüttelmann F, Kanber D, Horsthemke B, Gromoll J: Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1. Int J Androl; 2010 Aug 1;33(4):642-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1.
  • Using bisulfite sequencing, we determined the degree of methylation of the IGF2/H19 imprinting control region 1 (ICR1) and MEST differentially methylated regions in swim-up purified spermatozoa from 148 idiopathic infertile men and 33 normozoospermic controls.
  • All control individuals had a high degree of IGF2/H19 ICR1 and a low degree of MEST methylation.
  • Low sperm counts were clearly associated with IGF2/H19 ICR1 hypomethylation and, even stronger, with MEST hypermethylation.
  • MEST hypermethylation, but not IGF2/H19 ICR1 hypomethylation was found in idiopathic infertile men with progressive sperm motility below 40% and bad sperm morphology below 5% normal spermatozoa.
  • We conclude that idiopathic male infertility is strongly associated with imprinting defects at IGF2/H19 ICR1 and MEST, with aberrant MEST methylation being a strong indicator for sperm quality.
  • [MeSH-minor] Adult. Cohort Studies. DNA-Binding Proteins / genetics. Genomic Imprinting. Humans. Male. Methylation. Sperm Count. Sperm Motility / physiology

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  • (PMID = 19878521.001).
  • [ISSN] 1365-2605
  • [Journal-full-title] International journal of andrology
  • [ISO-abbreviation] Int. J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTCFL protein, human; 0 / DNA-Binding Proteins; 0 / IGF2 protein, human; 0 / Proteins; 0 / mesoderm specific transcript protein; 67763-97-7 / Insulin-Like Growth Factor II
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25. Schöherr N, Jäger S, Ranke MB, Wollmann HA, Binder G, Eggermann T: No evidence for isolated imprinting mutations in the PEG1/MEST locus in Silver-Russell patients. Eur J Med Genet; 2008 Jul-Aug;51(4):322-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] No evidence for isolated imprinting mutations in the PEG1/MEST locus in Silver-Russell patients.
  • Methylation-specific PCR was carried out for the PEG1/MEST locus in 7q31.
  • This test detects all known segmental and complete UPD7 cases.
  • The exclusion of isolated imprinting defects in our study population shows that this type of epimutation at the PEG1/MEST locus in 7q31 does not play a relevant role in SRS.

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  • (PMID = 18585117.001).
  • [ISSN] 1769-7212
  • [Journal-full-title] European journal of medical genetics
  • [ISO-abbreviation] Eur J Med Genet
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Proteins; 0 / mesoderm specific transcript protein
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26. Imamura T, Kerjean A, Heams T, Kupiec JJ, Thenevin C, Pàldi A: Dynamic CpG and non-CpG methylation of the Peg1/Mest gene in the mouse oocyte and preimplantation embryo. J Biol Chem; 2005 May 20;280(20):20171-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dynamic CpG and non-CpG methylation of the Peg1/Mest gene in the mouse oocyte and preimplantation embryo.
  • In somatic tissues, the CpG island of the imprinted Peg1/Mest gene is methylated on the maternal allele.
  • After short in vitro culture, Peg1/Mest became hypermethylated, whereas prolonged in vitro culture resulted in demethylation in a fraction of oocytes.

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  • (PMID = 15778220.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins; 0 / mesoderm specific transcript protein; 9007-49-2 / DNA
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27. McMinn J, Wei M, Sadovsky Y, Thaker HM, Tycko B: Imprinting of PEG1/MEST isoform 2 in human placenta. Placenta; 2006 Feb-Mar;27(2-3):119-26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imprinting of PEG1/MEST isoform 2 in human placenta.
  • MEST) is expressed in human placental trophoblast and endothelium, and data from knockout mice show that this gene regulates placental and fetal growth.
  • Isoform 1 of PEG1 mRNA initiates from exon 1c and produces the long form of the MEST protein.
  • This isoform is imprinted, with expression only from the paternal allele in many human and mouse organs, including placenta.
  • In contrast, PEG1 isoform 2, initiating from exon 1a and producing the short form of MEST protein, is biallelically expressed (non-imprinted) in several non-placental organs.
  • A CpG island overlapping PEG1 exon 1a is unmethylated in various fetal and adult non-placental tissues, but is often substantially methylated in the placenta, with the extent of methylation in a large series approximating a normal distribution.
  • [MeSH-minor] Adult. Alleles. CpG Islands. DNA / analysis. DNA / metabolism. Exons. Female. Genetic Markers / genetics. Genetic Variation. Humans. Protein Isoforms / genetics. RNA, Messenger / analysis. RNA, Messenger / metabolism. Trophoblasts / chemistry. Trophoblasts / metabolism

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  • (PMID = 16338457.001).
  • [ISSN] 0143-4004
  • [Journal-full-title] Placenta
  • [ISO-abbreviation] Placenta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Protein Isoforms; 0 / Proteins; 0 / RNA, Messenger; 0 / mesoderm specific transcript protein; 9007-49-2 / DNA
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28. Chu LC, Hruban RH, Horton KM, Fishman EK: Mixed epithelial and stromal tumor of the kidney: radiologic-pathologic correlation. Radiographics; 2010 Oct;30(6):1541-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed epithelial and stromal tumor of the kidney: radiologic-pathologic correlation.
  • Mixed epithelial and stromal tumor (MEST) of the kidney is a rare, typically benign lesion that occurs predominantly in perimenopausal women.
  • MEST may mimic a variety of benign and malignant renal lesions, such as adult cystic nephroma, complex renal cyst, and cystic renal cell carcinoma.
  • The preoperative diagnosis of MEST can be problematic, and most cases are treated surgically.
  • However, CT with two-dimensional multiplanar reformation and three-dimensional volume rendering helps define the diagnostic features of MEST and can assist in surgical planning.
  • [MeSH-major] Kidney Neoplasms / radiography. Neoplasms, Complex and Mixed / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Imaging, Three-Dimensional. Male. Middle Aged

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  • [Copyright] © RSNA, 2010.
  • (PMID = 21071374.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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29. Raes F, Williams JM, Hermans D: Reducing cognitive vulnerability to depression: a preliminary investigation of MEmory Specificity Training (MEST) in inpatients with depressive symptomatology. J Behav Ther Exp Psychiatry; 2009 Mar;40(1):24-38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reducing cognitive vulnerability to depression: a preliminary investigation of MEmory Specificity Training (MEST) in inpatients with depressive symptomatology.
  • The MEmory Specificity Training (MEST) was administered on a weekly basis for 4 consecutive weeks to 10 inpatients with depressive symptomatology.
  • Whereas earlier studies found that memory specificity does not improve following treatment as usual, the present results showed that participants' retrieval style became significantly more specific following MEST.
  • These results suggest that the MEST may offer a potential and promising intervention to tackle a core cognitive process involved in depression and depressive vulnerability.
  • [MeSH-minor] Adult. Analysis of Variance. Female. Humans. Middle Aged. Neuropsychological Tests. Problem Solving / physiology. Severity of Illness Index. Surveys and Questionnaires

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  • (PMID = 18407245.001).
  • [ISSN] 0005-7916
  • [Journal-full-title] Journal of behavior therapy and experimental psychiatry
  • [ISO-abbreviation] J Behav Ther Exp Psychiatry
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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30. Mai KT, Elkeilani A, Veinot JP: Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. Pathology; 2007 Apr;39(2):235-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis.
  • AIMS: This article adds new cases and variants of MEST with discussion of the histopathogenesis.
  • METHODS AND RESULTS: Fourteen MEST were originally diagnosed as cystic nephroma which represents an incidence of 1.6% of renal neoplasms in adults.
  • In females, the stromal component showed areas of müllerian differentiation with positive immunoreactivity for oestrogen (ER) and progesterone receptors (PR) and CD10.
  • The epithelial component displayed features of müllerian epithelium and reactive renal tubular cells.
  • In two male cases, MEST consisted of fibrous and smooth muscle stroma and cysts lined only by reactive renal tubular cells.
  • CONCLUSIONS: MEST represents a tumour developing from müllerian-like stromal cells in the kidney.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Adult. Aged. Angiomyolipoma / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Kidney Diseases, Cystic / pathology. Male. Middle Aged. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Sex Factors

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  • (PMID = 17454754.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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31. Takahashi M, Kamei Y, Ezaki O: Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab; 2005 Jan;288(1):E117-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size.
  • We have found that mesoderm-specific transcript (Mest)/paternally expressed gene 1 (Peg1) gene expression was markedly enhanced in white adipose tissue of mice with diet-induced and genetically caused obesity/diabetes but not with streptozotocin-induced diabetes, which does not cause obesity.
  • Administration of pioglitazone, a drug for type II diabetes and activator of peroxisome proliferator-activated receptor (PPAR)gamma, in obese db/db mice reduced the enhanced expression of Mest mRNA in adipose tissue, concomitant with an increase in body weight and a decrease in the size of adipose cells.
  • Ectopic expression of Mest in 3T3-L1 cells caused increased gene expression of adipose markers such as PPARgamma, CCAAT/enhancer binding protein (C/EBP)alpha, and adipocyte fatty acid binding protein (aP)2.
  • In transgenic mice overexpressing Mest in adipose tissue, enhanced expression of the adipose genes was observed.
  • Thus Mest appears to enlarge adipocytes and could be a novel marker of the size of adipocytes.

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  • (PMID = 15353408.001).
  • [ISSN] 0193-1849
  • [Journal-full-title] American journal of physiology. Endocrinology and metabolism
  • [ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Dietary Fats; 0 / Hypoglycemic Agents; 0 / Proteins; 0 / RNA, Messenger; 0 / Thiazolidinediones; 0 / mesoderm specific transcript protein; X4OV71U42S / pioglitazone
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32. Suzuki S, Renfree MB, Pask AJ, Shaw G, Kobayashi S, Kohda T, Kaneko-Ishino T, Ishino F: Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby. Mech Dev; 2005 Feb;122(2):213-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby.
  • Imprinted gene orthologues of human and mouse p57(KIP2), IGF2 and PEG1/MEST genes were isolated. p57(KIP2) did not show stable monoallelic expression suggesting that it is not imprinted in marsupials.
  • The differentially methylated region (DMR) of the human and mouse PEG1/MEST promoter is absent in the wallaby.

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  • (PMID = 15652708.001).
  • [ISSN] 0925-4773
  • [Journal-full-title] Mechanisms of development
  • [ISO-abbreviation] Mech. Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / CDKN1C protein, human; 0 / Cdkn1c protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p57; 0 / DNA Primers; 0 / DNA, Complementary; 0 / Nuclear Proteins; 0 / Proteins; 0 / mesoderm specific transcript protein; 67763-97-7 / Insulin-Like Growth Factor II
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33. Sukov WR, Cheville JC, Lager DJ, Lewin JR, Sebo TJ, Lewin M: Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors. Hum Pathol; 2007 Sep;38(9):1432-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors.
  • Mixed epithelial stromal tumor of the kidney (MEST)/adult cystic nephroma (CN) is a lesion characterized by epithelial lined tubular or cystic structures interspersed within a variably prominent, distinctive spindle-cell stroma.
  • Although typically benign, cases with malignant features have been reported.
  • Herein, we report a MEST/CN with malignant stromal features and rhabdoid differentiation arising in the left kidney of an 84-year-old woman.
  • Histologically, the tumor displayed multiple tubules and variably sized cystic structures lined by benign epithelium with an intervening malignant-appearing spindle-cell stroma.
  • The malignant stroma displayed condensation in the regions surrounding the epithelial component consistent with the ovarian-like stroma typically observed in MEST/CN.
  • In addition, the stromal cells displayed extensive rhabdoid differentiation.
  • Immunohistochemical analysis revealed strong expression of cytokeratin 7, CAM 5.2, AE1/AE3, wide-spectrum keratin, and epithelial membrane antigen by the epithelial component.
  • The stromal component displayed strong immunohistochemical expression of WT-1, CD-99, CD-56, INI1, and estrogen receptor; focal actin positivity; and was negative for desmin, myogenin, and progesterone receptor.
  • To our knowledge, this represents the first report in the literature of malignant MEST with rhabdoid features and suggests that this entity should be considered in the diagnosis of renal stromal malignancies with prominent rhabdoid features.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / pathology. Kidney Neoplasms / pathology. Rhabdoid Tumor / pathology. Stromal Cells / pathology

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  • (PMID = 17707262.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Moon YS, Park SK, Kim HT, Lee TS, Kim JH, Choi YS: Imprinting and expression status of isoforms 1 and 2 of PEG1/MEST gene in uterine leiomyoma. Gynecol Obstet Invest; 2010;70(2):120-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imprinting and expression status of isoforms 1 and 2 of PEG1/MEST gene in uterine leiomyoma.
  • PEG1/MEST gene has been known to be an imprinting gene, which is associated with growth of mesodermal origin cells.
  • The purpose of this study was to investigate whether overexpression of PEG1/MEST gene in leiomyoma is associated with loss of imprinting of the gene (biallelic), or whether the overexpression occurs while maintaining the imprinting (monoallelic).
  • We investigated the expression and the imprinting status of PEG1/MEST and its isoforms in samples from 25 patients with uterine leiomyomas as well as in matched normal myometrial tissue.
  • All normal myometrial tissues and 19 of 20 leiomyomas showed monoallelic expression of PEG1/MEST.
  • Thus, these data demonstrated that tumorigenesis of leiomyoma is associated with overexpression of isoform 1 of PEG1/MEST gene, but not with loss of imprinting of the gene.

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20339302.001).
  • [ISSN] 1423-002X
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Proteins; 0 / RNA, Messenger; 0 / mesoderm specific transcript protein
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35. XU C, SU L, ZHOU Q, LI C, ZHAO S: Imprinting analysis of the porcine MEST gene in 75 and 90 day placentas and prenatal tissues. Acta Biochim Biophys Sin (Shanghai); 2007 Aug;39(8):633-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imprinting analysis of the porcine MEST gene in 75 and 90 day placentas and prenatal tissues.
  • Mouse mesoderm-specific transcript (MEST) has been identified as an imprinted gene and mapped to an imprinted region of mouse chromosome 6 (MMU6).
  • It plays essential roles in embryonic and placental growth, and it is required for maternal behavior in adult female mouse.
  • Here, we isolated the porcine MEST gene and detected a single nucleotide polymorphism in the 3 -untranslated region.
  • The results indicate that MEST was imprinted in placentas on days 75 and 90 of gestation as well as in the 75 d fetal heart, muscle, kidney, lung and liver.

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  • (PMID = 17687499.001).
  • [ISSN] 1672-9145
  • [Journal-full-title] Acta biochimica et biophysica Sinica
  • [ISO-abbreviation] Acta Biochim. Biophys. Sin. (Shanghai)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / DNA, Complementary; 0 / Proteins; 0 / mesoderm specific transcript protein
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36. Sireci AN, Rodriguez R, Swierczynski SL, Netto GJ, Argani P: Fat-predominant mixed epithelial stromal tumor (MEST): report of a unique case mimicking angiomyolipoma. Int J Surg Pathol; 2008 Jan;16(1):73-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-predominant mixed epithelial stromal tumor (MEST): report of a unique case mimicking angiomyolipoma.
  • A unique case of a mixed epithelial stromal tumor (MEST) that was predominantly composed of adipose tissue is reported here.
  • This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma.
  • [MeSH-major] Adipose Tissue / pathology. Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology

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  • (PMID = 18203791.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Desmin; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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37. Toledo MS, Tagliari L, Suzuki E, Silva CM, Straus AH, Takahashi HK: Effect of anti-glycosphingolipid monoclonal antibodies in pathogenic fungal growth and differentiation. Characterization of monoclonal antibody MEST-3 directed to Manpalpha1-->3Manpalpha1-->2IPC. BMC Microbiol; 2010;10:47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of anti-glycosphingolipid monoclonal antibodies in pathogenic fungal growth and differentiation. Characterization of monoclonal antibody MEST-3 directed to Manpalpha1-->3Manpalpha1-->2IPC.
  • RESULTS: In this paper, we describe a detailed characterization of an IgG2a monoclonal antibody (mAb), termed MEST-3, directed to the Paracoccidioides brasiliensis glycolipid antigen Pb-2 (Manpalpha1-->3Manpalpha1-->2IPC).
  • mAb MEST-3 also recognizes GIPCs bearing the same structure in other fungi.
  • Studies performed on fungal cultures clearly showed the strong inhibitory activity of MEST-3 on differentiation and colony formation of Paracoccidioides brasiliensis, Histoplasma capsulatum and Sporothrix schenckii.
  • Similar inhibitory results were observed when these fungi where incubated with a different mAb, which recognizes GIPCs bearing terminal residues of beta-D-galactofuranose linked to mannose (mAb MEST-1).
  • On the other hand, mAb MEST-2 specifically directed to fungal glucosylceramide (GlcCer) was able to promote only a weak inhibition on fungal differentiation and colony formation.

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  • (PMID = 20156351.001).
  • [ISSN] 1471-2180
  • [Journal-full-title] BMC microbiology
  • [ISO-abbreviation] BMC Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Fungal; 0 / Antibodies, Monoclonal; 0 / Antigens, Fungal; 0 / Glycosphingolipids; 0 / Immunoglobulin G
  • [Other-IDs] NLM/ PMC2831884
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38. Montironi R, Mazzucchelli R, Lopez-Beltran A, Martignoni G, Cheng L, Montorsi F, Scarpelli M: Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? Eur Urol; 2008 Dec;54(6):1237-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity?
  • OBJECTIVES: The term "renal epithelial and stromal tumour" (REST) was proposed recently to encompass the spectrum of findings observed in cystic nephroma (CN) and mixed epithelial and stromal tumour (MEST) of the kidney.
  • Our aim was to review the broad spectrum of usual and unusual clinical and morphologic findings observed in CN and MEST.
  • METHODS: Based on Medline database searches, all aspects of CN and MEST were assessed.
  • RESULTS: CN and MEST have a remarkable similarity in sex predilection, age distribution, and morphologic attributes of both the epithelial and stromal components and immunohistochemical profile, albeit with variation in individual categories, with higher prevalence of stromal-to-epithelial ratio, prominent ovarian-like stroma, smaller cysts, and stromal luteinisation in MEST, and large cysts, thin septa, and low stromal-to-epithelial ratio in CN.
  • The stromal component in both lesions expresses estrogen and progesterone receptors.
  • Rare and unusual morphologic features, such as endometrioid, cervical, and intestinal differentiation, and luteinised ovarian-like stroma, have been described in MEST.
  • The epithelial element occasionally shows estrogen and progesterone receptors.
  • Even though an aggressive behaviour has been reported in very few cases, in general both neoplasms are considered benign and surgical excision is curative.
  • [MeSH-major] Kidney Neoplasms / classification. Kidney Neoplasms / pathology

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  • [CommentIn] Eur Urol. 2008 Dec;54(6):1245-6 [18006142.001]
  • [CommentIn] Eur Urol. 2009 Jul;56(1):e3 [19167806.001]
  • (PMID = 18006141.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 50
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39. Kagami M, Nagai T, Fukami M, Yamazawa K, Ogata T: Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST. J Assist Reprod Genet; 2007 Apr;24(4):131-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST.
  • METHODS: We examined methylation status of 31 cytosines at the CpG dinucleotides in the DMR of PEG1/MEST on 7q32.2 and 23 cytosines at the CpG dinucleotides in the DMR of H19 on 11p15, using leukocyte genomic DNA.
  • RESULTS: Eight of the 31 cytosines in the patient and four of the 31 cytosines in the father were hypermethylated in the PEG1/MEST-DMR.
  • CONCLUSION: The results suggest that hypermethylation of paternally expressed genes including PEG1/MEST, which usually have growth-promoting effects, may be relevant to LBW in subjects conceived by ART.

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  • (PMID = 17450433.001).
  • [ISSN] 1058-0468
  • [Journal-full-title] Journal of assisted reproduction and genetics
  • [ISO-abbreviation] J. Assist. Reprod. Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Proteins; 0 / mesoderm specific transcript protein
  • [Other-IDs] NLM/ PMC3455069
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40. Penkov LI, Kondrakhina MS, Mironova OV, Platonov ES: [Expression of imprinted Igf2 and Peg1/Mest genes in postimplantation parthenogenetic mouse embryos treated with transforming growth factor alpha in vitro]. Genetika; 2008 Aug;44(8):1148-52

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  • [Title] [Expression of imprinted Igf2 and Peg1/Mest genes in postimplantation parthenogenetic mouse embryos treated with transforming growth factor alpha in vitro].
  • The effect of transforming growth factor alpha (TGFt) on the expression of imprinted Igf2 and Peg1/Mest genes was studied in diploid parthenogenetic embryos (PEs) of (CBA x C57BL/6)F1 mice during the postimplantation period of embryogenesis.
  • The expression of the imprinted Igf2 and Peg1/Mest genes was studied by means of whole mount in situ hybridization using digoxigenin-labeled antisense RNAs.
  • The expression of the imprinted Igf2 and Peg1/Mest genes was studied in embryos on the tenth day of in utero development before culturing and after 24 and 48 h of culturing in vitro.
  • The expression of Igf2 before culturing was detected only in the brain of 60% of PEs on the tents day of pregnancy (the 21-to 25-somite stages); while the Peg1/Mest expression was not detected at all.
  • After 24 h of culturing, the Igf2 expression was detected in the brain of 71% of PEs at the 30- to 35-somite stages, while the Peg1/Mest expression was not detected.
  • After 48 h of culturing, Igf2 was expressed in the regions of the brain, developing jaws, heart, liver, and somites of all TGFalpha-treated PEs at the 40- to 45-somite stages; and Peg1/Mest was expressed in the brain, heart, and liver of these embryos.
  • In control (untreated) PEs, neither Igf2 nor Peg1/Mest was expressed at these stages The expression patterns of the imprinted Igf2 and Peg1/Mest genes in PEs at the most advanced developmental stages (40-45 somites) and in normal (fertilized) embryos at the same stages were similar; however, their expression rate in PEs was substantially lower than in normal embryos.

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  • (PMID = 18825967.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / IGF2 protein, mouse; 0 / Proteins; 0 / Transforming Growth Factor alpha; 0 / mesoderm specific transcript protein; 67763-97-7 / Insulin-Like Growth Factor II
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41. Riclet R, Chendeb M, Vonesch JL, Koczan D, Thiesen HJ, Losson R, Cammas F: Disruption of the interaction between transcriptional intermediary factor 1{beta} and heterochromatin protein 1 leads to a switch from DNA hyper- to hypomethylation and H3K9 to H3K27 trimethylation on the MEST promoter correlating with gene reactivation. Mol Biol Cell; 2009 Jan;20(1):296-305
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disruption of the interaction between transcriptional intermediary factor 1{beta} and heterochromatin protein 1 leads to a switch from DNA hyper- to hypomethylation and H3K9 to H3K27 trimethylation on the MEST promoter correlating with gene reactivation.
  • Here, we identified the imprinted mesoderm-specific transcript (MEST) gene as an endogenous TIF1beta primary target gene and demonstrated that transcriptional intermediary factor (TIF) 1beta, through its interaction with heterochromatin protein (HP) 1, is essential in establishing and maintaining a local heterochromatin-like structure on MEST promoter region characterized by H3K9 trimethylation and hypoacetylation, H4K20 trimethylation, DNA hypermethylation, and enrichment in HP1 that correlates with preferential association to foci of pericentromeric heterochromatin and transcriptional repression.
  • On disruption of the interaction between TIF1beta and HP1, TIF1beta is released from the promoter region, and there is a switch from DNA hypermethylation and histone H3K9 trimethylation to DNA hypomethylation and histone H3K27 trimethylation correlating with rapid reactivation of MEST expression.
  • Interestingly, we provide evidence that the imprinted MEST allele DNA methylation is insensitive to TIF1beta loss of function, whereas the nonimprinted allele is regulated through a distinct TIF1beta-DNA methylation mechanism.

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  • (PMID = 18923144.001).
  • [ISSN] 1939-4586
  • [Journal-full-title] Molecular biology of the cell
  • [ISO-abbreviation] Mol. Biol. Cell
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / Heterochromatin; 0 / Histones; 0 / Nuclear Proteins; 0 / Protein Isoforms; 0 / Proteins; 0 / Transcription Factors; 0 / mesoderm specific transcript protein; 0 / transcriptional intermediary factor 1; 107283-02-3 / heterochromatin-specific nonhistone chromosomal protein HP-1
  • [Other-IDs] NLM/ PMC2613122
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42. Jevremovic D, Lager DJ, Lewin M: Cystic nephroma (multilocular cyst) and mixed epithelial and stromal tumor of the kidney: a spectrum of the same entity? Ann Diagn Pathol; 2006 Apr;10(2):77-82
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  • [Title] Cystic nephroma (multilocular cyst) and mixed epithelial and stromal tumor of the kidney: a spectrum of the same entity?
  • The recently described mixed epithelial and stromal tumor (MEST) of the kidney and adult cystic nephroma (CN) (multilocular cyst) are rare benign cystic renal neoplasms that are composed of epithelial and stromal elements.
  • Our objective in this study was to evaluate cases of CN and MEST to define the morphological, immunophenotypic, and clinical features of these two entities.
  • Eleven cases from the files of a single institution diagnosed from 1996 to the present as either CN or MEST were reviewed.
  • Architecturally, all lesions were composed of multiple noncommunicating cysts lined by a single layer of epithelial cells.
  • All cases had areas with increased stromal cellularity and 8 cases had ovarian-like stroma present at least focally within the tumor.
  • No stromal or epithelial cell atypia, blastemal elements, or increased mitotic activity was appreciated.
  • The immunoprofile was also similar in the 7 cases stained and included epithelial reactivity with keratin and CAM 5.2 and stromal reactivity with estrogen receptor, progesterone receptor, smooth muscle actin, WT-1, vimentin, and focal desmin.
  • All cases have acted in a benign fashion with no history of recurrence or metastasis.
  • We propose that CN and MEST of the kidney represent a spectrum of the same entity.
  • If the diagnosis of CN is limited to cases that are comprised entirely of thin fibrous-walled cysts, all 11 of our cases would be classified as MEST.
  • [MeSH-major] Kidney Diseases, Cystic / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Complex and Mixed / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasms, Glandular and Epithelial / metabolism. Neoplasms, Glandular and Epithelial / pathology. Stromal Cells

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  • (PMID = 16546041.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Zhou M, Kort E, Hoekstra P, Westphal M, Magi-Galluzzi C, Sercia L, Lane B, Rini B, Bukowski R, Teh BT: Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. Am J Surg Pathol; 2009 Jan;33(1):72-80
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  • [Title] Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence.
  • Adult cystic nephroma (CN) and mixed epithelial and stromal tumor of the kidney (MEST) are considered as separate entities in the 2004 World Health Organization classification of renal neoplasms.
  • Gene expression profiles of 3 CN and 3 MEST were analyzed using HGU133 Plus 2.0 microarrays (Affymetrix) and were compared with each other and also with 48 other renal tumors and 13 normal kidneys.
  • Histologic examination of 26 CN and 13 MEST focused on the cystic septal thickness, cyst-to-stroma ratio, stromal cellularity and composition, types of epithelial cells lining cysts and glands, and estrogen and progesterone receptors expression.
  • Patients' age, sex distribution, and tumor size were similar between the two.
  • They also shared many histologic features, including lining epithelium of cysts and glands, stromal cellularity and composition.
  • By microarray analysis, progesterone receptor expression was significantly higher in CN and MEST relative to both normal and other renal tumors, while estrogen receptor expression was not.
  • By immunohistochemistry, expression of both receptors was similar between CN and MEST.
  • This study provides the most convincing molecular evidence that CN and MEST represent different parts of the morphologic spectrum of the same disease.
  • [MeSH-major] Kidney Diseases, Cystic / pathology. Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Female. Gene Expression. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Receptors, Estrogen / biosynthesis. Receptors, Progesterone / biosynthesis

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  • [CommentIn] Am J Surg Pathol. 2010 Jan;34(1):126-7; author reply 127 [20035151.001]
  • (PMID = 18971776.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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44. Kalinichev M, Starr KR, Teague S, Bradford AM, Porter RA, Herdon HJ: Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test. Brain Res; 2010 May 17;1331:105-13
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  • [Title] Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test.
  • In the present study we tested several glycine transporter 1 (GlyT1) inhibitors including NFPS, SSR 504734, Lu AA21279, Org 25935, SB-710622, GSK931145, as well as the glycine agonist d-serine, in the maximal electroshock threshold (MEST) test in the rat.
  • SB-710622 and GSK931145 had lower minimum effective doses (MEDs) in the MEST test than other GlyT1 inhibitors.

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20303337.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 2-(N-bis(2-methoxyethyl)amino)butyric acid,2',6'-dimethoxyphenyl ester hydrobromide; 0 / Anticonvulsants; 0 / Benzamides; 0 / GSK 931145; 0 / Glycine Plasma Membrane Transport Proteins; 0 / Phenols; 0 / Slc6a9 protein, rat; TE7660XO1C / Glycine
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45. Buritica C, Serrano M, Zuluaga A, Arrabal M, Regauer S, Nogales FF: Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma. J Clin Pathol; 2007 Jan;60(1):98-100
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  • [Title] Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma.
  • We report a case of a 9-cm mixed epithelial and stromal tumour of the kidney in an obese 70-year-old woman with diabetes.
  • The ovarian-type stroma had a spindle cell component that was positive for progesterone receptors and had the hitherto unreported presence of abundant foci of luteinised stromal cells with characteristic immunohistochemical positivity to alpha-inhibin, calretinin, aromatase and gonadotropin-releasing hormone (GnRH) receptors.
  • We conclude that the stromal component is identical to ovarian cortical stroma.
  • We believe that ovarian-type stroma occurs in extragenital tumours as a result of an epithelial-stromal interaction in an environment of hormonal hyperstimulation.
  • [MeSH-major] Kidney Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Aged. Diabetes Mellitus, Type 2 / complications. Female. Humans. Obesity / complications. Stromal Cells / pathology

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  • (PMID = 17213356.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1860583
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46. Kwon JE, Kang JH, Kwon GY: Mixed epithelial and stromal tumor of the kidney: a case report. J Korean Med Sci; 2007 Feb;22(1):159-62
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  • [Title] Mixed epithelial and stromal tumor of the kidney: a case report.
  • The descriptive term "mixed epithelial and stromal tumor of the kidney" was recently proposed for a group of renal tumors characterized histologically by a mixture of stromal and epithelial proliferation.
  • It is a rare benign neoplasm of the kidney which has been reported under various names such as adult type mesoblastic nephroma or others.
  • We report a case of mixed epithelial and stromal tumor in a 47 yr old female patient presenting as a partly cystic and partly solid renal mass.
  • Microscopically, the tumor exhibited spindle cell component in solid portion and epithelial proliferation around microcystic areas.
  • Immunoreactive profiles and ultrastructural examination suggested myofibroblastic nature of the stromal cells.
  • We believe this case exemplifies a unique adult renal tumor displaying both epithelial and stromal neoplastic component and has a few unusual features worthy of attention.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Nephroma, Mesoblastic / pathology

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  • (PMID = 17297273.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2693557
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47. Antic T, Perry KT, Harrison K, Zaytsev P, Pins M, Campbell SC, Picken MM: Mixed epithelial and stromal tumor of the kidney and cystic nephroma share overlapping features: reappraisal of 15 lesions. Arch Pathol Lab Med; 2006 Jan;130(1):80-5
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  • [Title] Mixed epithelial and stromal tumor of the kidney and cystic nephroma share overlapping features: reappraisal of 15 lesions.
  • CONTEXT: Cystic nephroma is a rare cystic tumor, which only recently has been recognized as an exclusively adult lesion.
  • Mixed epithelial and stromal tumor of the kidney is also a rare, recently recognized, biphasic tumor composed of tubular and cystic elements embedded in grossly recognizable spindle cell stroma.
  • OBJECTIVES: To compare clinical phenotype, morphology, and immunohistochemistry in mixed epithelial and stromal tumor of the kidney and cystic nephroma in order to explore the relationship between these 2 lesions.
  • DESIGN: Fifteen biphasic lesions (8 mixed epithelial and stromal tumors of the kidney and 7 cystic nephromas) were studied.
  • RESULTS: Mixed epithelial and stromal tumor of the kidney occurred exclusively in women aged 36 to 80 years (mean, 49.7 years), all of whom had a history of estrogen therapy and/or obesity.
  • Cystic nephroma occurred in both sexes; patients were aged 22 to 71 years (mean, 50.4 years), and a history of hormonal therapy was present on occasion.
  • All 15 lesions were benign.
  • In mixed epithelial and stromal tumors of the kidney, the stroma was positive for estrogen and progesterone receptors in 4 of 5 lesions tested.
  • In cystic nephroma, focal positivity for hormone receptors was seen in 2 of 7 tumors tested; both positive lesions were from women.
  • The epithelial lining in both mixed epithelial and stromal tumor of the kidney and cystic nephroma lesions was variable with regard to shape, cytoplasmic appearance, and immunophenotype (with focal positivity for CD10, cytokeratin 7, high-molecular-weight keratin, and Ulex europaeus detectable in both lesions).
  • CONCLUSIONS: While mixed epithelial and stromal tumor of the kidney has a strong association with the female sex and hormonal milieu, cystic nephroma can affect both sexes and, on occasion, may also have hormonal associations.
  • Our studies also suggest that the tubules may be entrapped rather than comprising an intrinsic component of the tumor.
  • [MeSH-major] Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasms, Glandular and Epithelial / metabolism. Neoplasms, Glandular and Epithelial / pathology. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 16390243.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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48. Kawakami T, Sugimoto H, Furuichi R, Kadota Y, Inoue M, Setsu K, Suzuki S, Sato M: Cadmium reduces adipocyte size and expression levels of adiponectin and Peg1/Mest in adipose tissue. Toxicology; 2010 Jan 12;267(1-3):20-6
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  • [Title] Cadmium reduces adipocyte size and expression levels of adiponectin and Peg1/Mest in adipose tissue.

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  • [Copyright] 2009. Published by Elsevier Ireland Ltd.
  • (PMID = 19666079.001).
  • [ISSN] 1879-3185
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Adiponectin; 0 / PPAR gamma; 0 / Proteins; 0 / RNA, Messenger; 0 / mesoderm specific transcript protein; 00BH33GNGH / Cadmium; 9038-94-2 / Metallothionein
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49. Chou HP, Ou YC, Cheng CL, Yang CR: Mixed epithelial and stromal tumor of the kidney. J Chin Med Assoc; 2006 Mar;69(3):140-2
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  • [Title] Mixed epithelial and stromal tumor of the kidney.
  • Abdominal computed tomography revealed a huge cystic heterogenic tumor about 20 cm in largest diameter occupying the entire left kidney.
  • The pathology report confirmed the diagnosis of mixed epithelial and stromal tumor of the kidney.
  • From pathologic survey, the spindle cells of this tumor were positive for muscle markers and expressed estrogen and/or progesterone receptors.
  • We suggest that a mixed epithelial and stromal tumor of the kidney should be considered in all cystic renal tumors presenting in perimenopausal women.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 16599022.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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50. Thyavihally YB, Tongaonkar HB, Desai SB: Benign mixed epithelial stromal tumor of the renal pelvis with exophytic growth: case report. Int Semin Surg Oncol; 2005 Sep 9;2:18
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  • [Title] Benign mixed epithelial stromal tumor of the renal pelvis with exophytic growth: case report.
  • BACKGROUND: Mixed epithelial and stromal tumor (MEST) is a distinctive benign composite neoplasm of the kidney predominantly seen in females mostly in the perimenopausal period.
  • A computed tomography scan of abdomen and pelvis showed a 9 x 7 cm uniformly solid mass with poor contrast enhancement situated in the inferomedial aspect of the left kidney.
  • The mass was excised preserving the kidney.
  • Microscopically, the tumor was composed of large collagenized areas containing bundles of spindle cells and several 'microcysts' lined by cuboidal epithelium suggestive of a benign mixed epithelial stromal tumor.
  • DISCUSSION: Mixed epithelial tumors usually present in perimenopausal women as a partially cystic mass.
  • Tumors are composed of irregular mixtures of cystic and solid areas, glands with variable complexity and distribution and the stromal component is characterized by a spindle cell proliferation.
  • CONCLUSION: MEST is a distinctive benign tumor of the kidney that should be distinguished from other renal neoplasms.
  • MEST arising from the renal pelvis and growing exophytically is a rare entity.

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  • (PMID = 16150156.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1215508
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51. Hora M, Hes O, Michal M, Boudová L, Chudácek Z, Kreuzberg B, Klecka J: Extensively cystic renal neoplasms in adults (Bosniak classification II or III)--possible "common" histological diagnoses: multilocular cystic renal cell carcinoma, cystic nephroma, and mixed epithelial and stromal tumor of the kidney. Int Urol Nephrol; 2005;37(4):743-50
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  • [Title] Extensively cystic renal neoplasms in adults (Bosniak classification II or III)--possible "common" histological diagnoses: multilocular cystic renal cell carcinoma, cystic nephroma, and mixed epithelial and stromal tumor of the kidney.
  • RESULTS: Seven multilocular cystic renal cell carcinomas, three mixed epithelial and stromal tumour of the kidney and one cystic nephroma were diagnosed on histology.
  • CONCLUSION(S): Extensively cystic renal tumours classified as the Bosniak type II or III correspond histologically to the entities mentioned above (multilocular cystic renal cell carcinoma, cystic nephroma, mixed epithelial and stromal tumour of the kidney).
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Nephrectomy. Retrospective Studies. Wilms Tumor / pathology

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  • (PMID = 16362592.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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52. Sharma JB, Aruna J, Mittal S, Sharma MC: Mixed epithelial and stromal tumor of the kidney in a puerperal woman. J Obstet Gynaecol Res; 2007 Aug;33(4):574-7
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  • [Title] Mixed epithelial and stromal tumor of the kidney in a puerperal woman.
  • Mixed epithelial and stromal tumor of the kidney (MESTK) is a recently recognized subset of renal tumors composed mainly of smooth muscle cells in which epithelial structures are embedded.
  • In the present case report, a 36-year-old woman presented with puerperal pyrexia, possibly due to tuberculosis and with an incidental mixed epithelial and stromal tumor of the kidney causing complex ascitis and fever, which required nephrectomy that was followed by full recovery.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Adult. Female. Humans. Nephrectomy. Postpartum Period

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  • (PMID = 17688634.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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53. Rauf F, Yaqoob N, Husain A: Mixed epithelial and stromal tumour of kidney. J Pak Med Assoc; 2006 Jul;56(7):340-1
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  • [Title] Mixed epithelial and stromal tumour of kidney.
  • Mixed epithelial and stromal tumour of kidney is a recently described, rare entity and includes cases previously termed as cystic hamartoma of renal pelvis and adult mesoblastic nephroma.
  • During ultrasound abdomen, a solid right renal mass was incidentally found in upper pole of right kidney.
  • On gross examination it was a 3.5 cm diameter mass which was microscopically composed of both epithelial and stromal components in the form of cystically dilated tubules and fascicles of spindle shaped cells.
  • [MeSH-major] Epithelial Cells / pathology. Kidney Neoplasms / surgery. Kidney Neoplasms / ultrasonography. Stromal Cells / pathology
  • [MeSH-minor] Adult. Female. Humans. Nephrectomy

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  • (PMID = 16900720.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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54. Parikh P, Chan TY, Epstein JI, Argani P: Incidental stromal-predominant mixed epithelial-stromal tumors of the kidney: a mimic of intraparenchymal renal leiomyoma. Arch Pathol Lab Med; 2005 Jul;129(7):910-4
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  • [Title] Incidental stromal-predominant mixed epithelial-stromal tumors of the kidney: a mimic of intraparenchymal renal leiomyoma.
  • CONTEXT: Mixed epithelial-stromal tumor of the kidney is a recently recognized benign renal tumor that usually occurs in adult women and typically forms a sizable lesion with solid and cystic areas.
  • The recognized morphologic spectrum of this recently described entity is evolving.
  • OBJECTIVE: To review the clinicopathologic features of 3 small mixed epithelial-stromal tumors of the kidney that were incidental findings in kidneys removed for other reasons.
  • DESIGN: The clinical presentation and morphologic findings of the 3 cases were reviewed.
  • RESULTS: All 3 lesions contained predominantly fascicles of smooth muscle mimicking leiomyoma, but they also had cellular subpopulations of smaller, müllerian-appearing stromal cells.
  • Although only the spindled smooth muscle cells were immunoreactive for muscle markers desmin and actin, both the spindled smooth muscle cells and the cellular müllerian-appearing stromal cells demonstrated diffuse nuclear labeling for estrogen and progesterone receptors.
  • CONCLUSIONS: Mixed epithelial-stromal tumor of the kidney may present as an incidental stromal-predominant lesion within the kidney.
  • Such lesions are easily confused with leiomyomas or stromal-predominant angiomyolipomas.
  • [MeSH-major] Angiomyolipoma / diagnosis. Kidney Neoplasms / diagnosis. Leiomyoma / diagnosis. Neoplasms, Complex and Mixed / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis. Smooth Muscle Tumor / diagnosis. Stromal Cells / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 15974815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Skov RL, Urth TR, Hansen DS: [Methicillin resistant S. aureus and multi-resistant Enterobacteriaceae. Two of the most significant resistance problems in Denmark]. Ugeskr Laeger; 2007 Dec 3;169(49):4259-62
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  • [Transliterated title] Methicillinresistente S. aureus og multiresistente Enterobacteriacea. To af de mest betydningsfulde resistensproblemer i Danmark.

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  • (PMID = 18208704.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Quinolones
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56. Sahni VA, Mortele KJ, Glickman J, Silverman SG: Mixed epithelial and stromal tumour of the kidney: imaging features. BJU Int; 2010 Apr;105(7):932-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed epithelial and stromal tumour of the kidney: imaging features.
  • OBJECTIVE: To describe the features on ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) of mixed epithelial and stromal tumours of the kidney.
  • PATIENTS AND METHODS: Five women with renal mixed epithelial and stromal tumours (mean age 55.6 years, range 49-59) who had preoperative imaging were retrospectively analysed.
  • RESULTS: All mixed epithelial and stromal tumours appeared as well-marginated, multi-septate cystic masses with a nodular component.
  • CONCLUSION: Mixed epithelial and stromal tumours of the kidney have a diverse radiographic appearance, indistinguishable from multilocular cystic nephroma and cystic renal cell carcinoma.
  • [MeSH-major] Kidney Neoplasms. Magnetic Resonance Imaging. Neoplasms, Glandular and Epithelial
  • [MeSH-minor] Female. Humans. Incidental Findings. Middle Aged. Retrospective Studies. Stromal Cells. Tomography, X-Ray Computed

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  • (PMID = 19818075.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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57. Hara N, Kawaguchi M, Murayama S, Maruyama R, Tanikawa T, Takahashi K: Mixed epithelial and stromal tumor of the kidney in a 12-year-old girl. Pathol Int; 2005 Oct;55(10):670-6
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  • [Title] Mixed epithelial and stromal tumor of the kidney in a 12-year-old girl.
  • Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare kidney neoplasm that almost exclusively occurs in perimenopausal women, and long-term estrogen replacement is relevant to its pathogenesis.
  • On surgical specimen it was found that the well-circumscribed tumor measuring 14 cm arose from the lower pole of the right kidney, showing solid and fibrous-cystic areas.
  • Microscopically, it was composed both of epithelial structures similar to renal tubules and stroma comprising non-specific spindle cells.
  • In addition, primitive ductal structures were reactive both for CD15 and lectins, but immature epithelial elements typical of nephroblastoma were absent.
  • The tumor was comparable with MESTK, although some epithelia were associated with the immunophenotype of proximal tubules.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Treatment Outcome

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  • (PMID = 16185300.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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58. Muller S, Oevermann A, Wenker C, Altermatt HJ, Robert N: A mixed epithelial and stromal tumor of the kidney in a ringtail lemur (Lemur catta). Vet Pathol; 2007 Mar;44(2):243-6
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  • [Title] A mixed epithelial and stromal tumor of the kidney in a ringtail lemur (Lemur catta).
  • This report describes a mixed epithelial and stromal tumor of the kidney (MESTK) in a 14.5-year-old female ringtail lemur.
  • The well-demarcated, solid, and cystic mass was located in the pelvis of the left kidney and consisted histologically of both epithelial and mesenchymal components.
  • Neither the mesenchymal nor the epithelial parts showed significant nuclear atypia or mitotic figures.
  • In humans this tumor affects predominantly perimenopausal women and can express estrogen and progesterone receptors.
  • However, neither estrogen nor progesterone receptors could be identified by immunohistochemistry in the tumor of the present ringtail lemur.
  • [MeSH-major] Kidney Neoplasms / veterinary. Lemur. Neoplasms, Glandular and Epithelial / veterinary. Primate Diseases / pathology
  • [MeSH-minor] Animals. Animals, Zoo. Fatal Outcome. Female. Immunohistochemistry / veterinary. Stromal Cells / pathology

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  • (PMID = 17317808.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Nikonova L, Koza RA, Mendoza T, Chao PM, Curley JP, Kozak LP: Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J; 2008 Nov;22(11):3925-37
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  • A 50-fold variation in mRNA and protein levels of the mesoderm-specific transcript gene (Mest) in white fat of C57BL/6J (B6) mice fed an obesogenic diet is positively correlated with expansion of fat mass.
  • MEST protein was detected only in adipocytes, in which its induction occurred with both unsaturated and saturated dietary fat.
  • To test the hypothesis that MEST modulates fat mass expansion, its expression was compared to that of stearoyl CoA desaturase (Scd1) in B6 mice exposed to diets and environmental temperatures that generated conditions separating the effects of food intake and adiposity.
  • Under a range of conditions, Mest expression was always associated with variations in adiposity, whereas Scd1 expression was associated with the amount of saturated fat in the diet.
  • Mest mRNA was expressed at its highest levels during early postnatal growth at the onset of the most rapid phase of fat mass expansion.
  • MEST is localized to the endoplasmic reticulum/Golgi apparatus where its putative enzymatic properties as a lipase or acyltransferase, predicted from sequence homology with members of the alpha/beta fold hydrolase superfamily, can enable it to function in lipid accumulation under conditions of positive energy balance.
  • Variations in adiposity and Mest expression in genetically identical mice also provides a model of epigenetic regulation.

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  • (PMID = 18644838.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR021945; United States / NIDDK NIH HHS / DK / P30 DK072476; United States / NIDDK NIH HHS / DK / P-30 DK072476; United States / NCRR NIH HHS / RR / P20-RR021945
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats, Unsaturated; 0 / Proteins; 0 / RNA, Messenger; 0 / mesoderm specific transcript protein; EC 1.14.19.1 / Scd1 protein, mouse; EC 1.14.19.1 / Stearoyl-CoA Desaturase; EC 2.3.- / Acyltransferases; EC 3.1.1.3 / Lipase
  • [Other-IDs] NLM/ PMC2574032
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60. Tsuchiyama K, Ueki O, Minami H, Kawaguchi K, Sato K, Katsuda S: [Mixed epithelial and stromal tumor of the kidney: a case report]. Hinyokika Kiyo; 2009 Apr;55(4):219-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mixed epithelial and stromal tumor of the kidney: a case report].
  • We report a case of a mixed epithelial and stromal tumor of the kidney.
  • A 64-year-old female who had no complaint was found to have a left renal tumor by computed tomography (CT) for an examination of a right breast tumor and was referred to our department.
  • CT revealed a gradually enhancing 5 cm mass in the left kidney.
  • The patient underwent left radical nephrectomy, and the tumor was histologically diagnosed as a mixed epithelial and stromal tumor.
  • [MeSH-major] Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Epithelial Cells / pathology. Female. Humans. Stromal Cells / pathology

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  • (PMID = 19462828.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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61. Wang H, Kuang D, Fang Z: Diffraction analysis of blazed transmission gratings with a modified extended scalar theory. J Opt Soc Am A Opt Image Sci Vis; 2008 Jun;25(6):1253-9
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  • An alternative interpretation of the diffraction of blazed transmission gratings with moderate structure period is proposed according to a modified extended scalar theory (MEST).
  • It is observed that MEST gives the total field that agrees with rigorous coupled-wave analysis (RCWA), and the result is more reliable than that of extended scalar theory (EST).
  • The MEST is still a ray-optical-based approximation approach, and the region of validity is compared with EST and RCWA.

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  • (PMID = 18516135.001).
  • [ISSN] 1084-7529
  • [Journal-full-title] Journal of the Optical Society of America. A, Optics, image science, and vision
  • [ISO-abbreviation] J Opt Soc Am A Opt Image Sci Vis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. da Silva CS, Adad SJ, Saldanha JC, Cançado CG, Bachi C, Murta EF: Synchronous sertoli cell and serous cystadenoma tumors of the ovaries with mixed epithelial and stromal tumor of the kidney: a case report. Clin Genitourin Cancer; 2007 Jun;5(5):338-40
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  • [Title] Synchronous sertoli cell and serous cystadenoma tumors of the ovaries with mixed epithelial and stromal tumor of the kidney: a case report.
  • Ultrasonography demonstrated a solid mass in the upper pole of the right kidney and a predominantly solid pelvic abdominal mass.
  • The patient underwent laparotomy on the renal tumor, which was thought to have a probable ovarian metastasis.
  • Immunohistochemical and histopathologic assessment identified a right ovarian Sertoli cell tumor, a left ovarian serous cystadenoma, and a mixed epithelial-stromal tumor in the kidney with positive hormonal receptor.
  • Because our patient had an ovarian neoplasm producing steroids and a kidney tumor expressing hormonal receptors, the hypothesis of possible endocrine dependence in the pathogenesis of mixed epithelial stromal tumor is reinforced.
  • [MeSH-major] Cystadenoma, Serous / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology. Ovarian Neoplasms / pathology. Sertoli Cell Tumor / pathology. Sex Cord-Gonadal Stromal Tumors / pathology

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  • (PMID = 17645832.001).
  • [ISSN] 1558-7673
  • [Journal-full-title] Clinical genitourinary cancer
  • [ISO-abbreviation] Clin Genitourin Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Koza RA, Rogers P, Kozak LP: Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation. Epigenetics; 2009 Oct 1;4(7):512-8
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  • Mesoderm specific transcript (Mest), an imprinted gene associated with fat mass expansion under conditions of positive energy balance, shows highly variable expression (approximately 80-fold) in white adipose tissue (WAT) of C57BL/6J (B6) mice fed an obesogenic diet.
  • Since B6 mice are essentially genetically invariant and Mest is known to be regulated by CpG methylation within its immediate proximal promoter, the large variability in its expression in adipose tissue has the hallmarks of being controlled via an epigenetic mechanism.
  • In this study, bisulfite sequencing and allelic discrimination analyses were performed to determine whether variations in CpG methylation within the Mest promoter were associated with its expression.
  • Results showed no relationship between CpG methylation in the Mest promoter and high versus low expression in either WAT or isolated adipocytes; and, experiments using a single nucleotide polymorphism in the Mest promoter region between B6 and Castaneus mice showed the expected pattern for an imprinted gene with all maternal alleles being methylated.
  • These data suggest that mechanisms independent of the CpG methylation status of the Mest promoter must underlie the control of its expression during adipose tissue expansion.

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  • (PMID = 19875931.001).
  • [ISSN] 1559-2308
  • [Journal-full-title] Epigenetics
  • [ISO-abbreviation] Epigenetics
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR021945; United States / NIDDK NIH HHS / DK / P30 DK072476; United States / NIDDK NIH HHS / DK / R21 DK074951; United States / NCRR NIH HHS / RR / P20-RR021945
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats; 0 / Proteins; 0 / mesoderm specific transcript protein
  • [Other-IDs] NLM/ NIHMS559296; NLM/ PMC3951159
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64. Velmahos GC, Petrone P, Chan LS, Hanks SE, Brown CV, Demetriades D: Electrostimulation for the prevention of deep venous thrombosis in patients with major trauma: a prospective randomized study. Surgery; 2005 May;137(5):493-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Muscle electrostimulation (MEST) has been used over the years with mixed-but predominantly encouraging-results for a variety of conditions, including prevention of deep venous thrombosis (DVT).
  • METHODS: Trauma patients with Injury Severity Score higher than 9 who were admitted to the intensive care unit and had a contraindication for prophylactic heparinization were randomized to groups MEST and control.
  • MEST patients received 30-minute MEST sessions twice daily for 7 to 14 days.
  • RESULTS: After exclusions, 26 MEST and 21 control patients completed the study and received outcome evaluation by venography (25) or duplex (22).
  • Three patients in each group developed proximal DVT (11.5% vs 14%, P = .79), and an additional 4 (15%) MEST group and 3 (14%) control group patients developed peripheral DVT ( P = .96).
  • CONCLUSIONS: MEST was not effective in decreasing DVT rates in major trauma patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Injury Severity Score. Leg / blood supply. Leg / radiography. Leg / ultrasonography. Male. Middle Aged. Muscle, Skeletal. Prospective Studies. Treatment Failure

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  • (PMID = 15855919.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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65. Sibony M, Vieillefond A: [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology]. Ann Pathol; 2008 Oct;28(5):381-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology].
  • The group of oncocytomas/chromophobe renal cell carcinomas can be considered as a spectrum from benign (oncocytoma) to malignant neoplasm (chromophobe renal cell carcinoma).
  • Angiomyolipoma is usually a benign mesenchymatous neoplasm, that can be sporadic or familial (tuberous sclerosis).
  • Renal epithelial and stromal tumors (REST) is a new concept gathering two benign mixed mesenchymal and epithelial tumors: cystic nephroma and mixed epithelial and stromal tumors (MEST).
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / classification. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma / classification. Carcinoma / genetics. Carcinoma / pathology. Chromosome Mapping. Chromosomes, Human. Humans. Immunohistochemistry. Kidney / pathology. Kidney Tubules, Collecting / pathology. Necrosis

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  • (PMID = 19068393.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 84
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66. Goszczyk A, Straz-Zebrowska E, Jung A: [Kidney tumor in 12-year-old girl--case study of the rare histopatologic form of neoplasm in children]. Pol Merkur Lekarski; 2008;24 Suppl 4:10-1
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Kidney tumor in 12-year-old girl--case study of the rare histopatologic form of neoplasm in children].
  • The authors present an atypical case of MEST uncovered in 12-year-old girl diagnosed with recurrent pyuria and persistent albuminuria with concomitant hypertension.
  • While investigating these changes, USG, urography, CT and MRI were performed and these manifested tumor-like change in the right kidney.
  • Microscopically MEST was found while infection was found in parenchyma.
  • Mixed epithelial and stromal tumor is a very rare kidney tumor that occurs almost exclusively in perimenopausal women or women after a long-term estrogen replacement.
  • There are only few cases of this tumor in premenarcheal girls described in literature.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Nephroma, Mesoblastic / diagnosis. Nephroma, Mesoblastic / pathology
  • [MeSH-minor] Albuminuria / etiology. Child. Female. Humans. Hypertension / etiology. Nephrectomy. Pyuria / etiology. Rare Diseases. Recurrence. Stromal Cells / pathology

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  • (PMID = 18924491.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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67. Liang XW, Zhu JQ, Miao YL, Liu JH, Wei L, Lu SS, Hou Y, Schatten H, Lu KH, Sun QY: Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte. Biochem Biophys Res Commun; 2008 Jun 20;371(1):16-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte.
  • In this study, we employed bisulfite sequencing and COBRA methods to investigate the DNA methylation status of differentially methylated regions (DMRs) of Snrpn and Peg1/Mest, two maternally imprinted genes, in postovulatory oocytes aged in vivo and in vitro.
  • However, Peg1/Mest did not show any demethylation in all aged groups at 29h post-hCG.

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  • (PMID = 18381202.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Proteins; 0 / Ribonucleoproteins, Small Nuclear; 0 / Sulfites; 0 / mesoderm specific transcript protein; 0 / snRNP Core Proteins; 9007-49-2 / DNA; OJ9787WBLU / hydrogen sulfite
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68. Ferraro TN, Smith GG, Schwebel CL, Lohoff FW, Furlong P, Berrettini WH, Buono RJ: Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains. Physiol Genomics; 2007 Nov 14;31(3):458-62
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  • [Title] Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains.
  • To confirm the presence and refine the position of the chromosome 5 QTL for maximal electroshock seizure threshold (MEST), reciprocal congenic strains between B6 and D2 mice were created by a DNA marker-assisted backcross breeding strategy and studied with respect to changes in MEST.
  • Comparison of MEST between congenic and control (parental genetic background) mice indicates that genes influencing this trait were captured in all strains.
  • Thus, mice from strains having D2 alleles from chromosome 5 on a B6 genetic background exhibit significantly lower MEST compared with control littermates, whereas congenic mice harboring B6 chromosome 5 alleles on a D2 genetic background exhibit significantly higher MEST compared with control littermates.
  • Combining data from all congenic strains, we conclude that the gene(s) underlying the chromosome 5 QTL for MEST resides in the interval between D5Mit108 (26 cM) and D5Mit278 (61 cM).

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  • (PMID = 17698926.001).
  • [ISSN] 1531-2267
  • [Journal-full-title] Physiological genomics
  • [ISO-abbreviation] Physiol. Genomics
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS-40554
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Okada Y, Sakaue H, Nagare T, Kasuga M: Diet-induced up-regulation of gene expression in adipocytes without changes in DNA methylation. Kobe J Med Sci; 2009;54(5):E241-9
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  • We have now shown that maintenance of C57BL/6J mice on a high-fat diet for 16 weeks resulted in marked up-regulation of the expression of leptin, Mest (mesoderm specific transcript; also known as paternally expressed gene 1, or Peg1), and sFRP5 (secreted frizzled-related protein 5) genes in WAT.
  • Furthermore, the demethylating agent 5-aza-2'-deoxycytidine increased the amount of Mest/Peg1 mRNA, but not that of leptin or sFRP5 mRNAs, in mouse 3T3-L1 adipocytes.
  • However, analysis by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry revealed that maintenance of mice on a high-fat diet for various times did not affect the level of methylation at specific CpG sites in the promoter regions of leptin, Mest/Peg1, and sFRP5 genes in WAT.
  • Our results indicate that the diet-induced up-regulation of leptin, Mest/Peg1, and sFRP5 gene expression in WAT during the development of obesity in mice is not mediated directly by changes in DNA methylation.

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  • (PMID = 19628964.001).
  • [ISSN] 1883-0498
  • [Journal-full-title] The Kobe journal of medical sciences
  • [ISO-abbreviation] Kobe J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Dietary Fats; 0 / Intercellular Signaling Peptides and Proteins; 0 / Leptin; 0 / Proteins; 0 / Sfrp5 protein, mouse; 0 / mesoderm specific transcript protein; 776B62CQ27 / decitabine; M801H13NRU / Azacitidine
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70. Cho WK: Safety regulation for the design approval of special form radioactive sources. Appl Radiat Isot; 2009 Jul-Aug;67(7-8):1304-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Special form radioactive sources should meet strict safety requirements specified in the domestic safety regulations and the design of the sources should be certified by the regulatory authority, the Ministry of Education, Science and Technology (MEST).
  • Several safety tests such as impact, percussion, heating, and leak tests are performed on the sources according to the domestic regulations and the international safety standards such as ANSI N542-1977 and ISO 2919-1999(E).
  • As a regulatory expert body, Korea Institute of Nuclear Safety (KINS) assesses various types of application documents, such as safety analysis report, quality assurance program, and other documents evidencing fulfillment of requirements for design approval of the special form radioactive sources, submitted by a legal person who intends to produce special form radioactive sources and then reports the assessment result to MEST.
  • A design approval certificate is issued to the applicant by MEST on the basis of a technical evaluation report presented by KINS.

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  • (PMID = 19321351.001).
  • [ISSN] 1872-9800
  • [Journal-full-title] Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • [ISO-abbreviation] Appl Radiat Isot
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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71. Ferraro TN, Smith GG, Schwebel CL, Doyle GA, Ruiz SE, Oleynick JU, Lohoff FW, Berrettini WH, Buono RJ: Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred mice. Physiol Genomics; 2010 Sep;42A(1):1-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We measured thresholds for generalized electroshock seizure (GEST) and maximal electroshock seizure (MEST) in congenic strains and B6-like littermates and also tested their responses to kainic acid (KA) and pentylenetetrazol (PTZ).
  • Results document that MEST is significantly lower in strains 15M and 15D, which harbor medial and distal (telomeric) segments of chr 15 (respectively) from D2, compared with strain 15P, which harbors the proximal (acromeric) segment of chr 15 from D2, and with control littermates.
  • Taken together, results suggest there are multiple SZS QTLs on chr 15 and that two QTLs harbor gene variants that affect MEST and KA SZS independently.
  • The MEST QTL is refined to a 19 Mb region flanked by rs13482630 and D15Mit159.

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  • (PMID = 20571108.001).
  • [ISSN] 1531-2267
  • [Journal-full-title] Physiological genomics
  • [ISO-abbreviation] Physiol. Genomics
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS-40554
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2957772
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72. Andrade AC, Lui JC, Nilsson O: Temporal and spatial expression of a growth-regulated network of imprinted genes in growth plate. Pediatr Nephrol; 2010 Apr;25(4):617-23
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  • Similar to the coordinated decline previously observed in kidney, lung, liver, and heart, expression of all genes, except Gtl2, decreased with age in metaphyseal bone.
  • On the contrary, Mest, Dlk1, H19, and Gtl2 decreased, and Cdkn1c, Grb10, and Slc38a4 increased with age in growth plate.
  • During differentiation from resting to hypertrophic zone, Mest, Dlk1, Grb10, and Gtl2 expression decreased, whereas Slc38a4 expression increased.
  • In particular, developmental changes in the expression of growth-promoting genes, Mest, Dlk1, Gtl2, and growth-inhibitory genes, Cdkn1c and Grb10, may contribute to the decline in longitudinal bone growth that occurs with age.

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  • (PMID = 19902269.001).
  • [ISSN] 1432-198X
  • [Journal-full-title] Pediatric nephrology (Berlin, Germany)
  • [ISO-abbreviation] Pediatr. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Proteins; 0 / RNA, Messenger
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73. Marques CJ, Costa P, Vaz B, Carvalho F, Fernandes S, Barros A, Sousa M: Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. Mol Hum Reprod; 2008 Feb;14(2):67-74

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  • Genomic imprinting marks in the male germ line are already established in the adult germinal stem cell population.
  • We studied the methylation patterns of H19 and MEST imprinted genes in sperm of control and oligozoospermic patients, by bisulphite genomic sequencing.
  • We here report that 7 out of 15 (46.7%) patients with a sperm count below 10 x 10(6)/ml display defective methylation of H19 and/or MEST imprinted genes.
  • Conversely, hypermethylation occurred in 8.3% (3.8-12.2%) and complete methylation in 6.1% (3.8-7.6%) of MEST clones.
  • Of the seven patients presenting imprinting errors, two had both H19 hypomethylation and MEST hypermethylation, whereas five displayed only one imprinted gene affected.
  • The frequency of patients with MEST hypermethylation was highest in the severe oligozoospermia group (2/5 patients), whereas H19 hypomethylation was more frequent in the moderate oligozoospermia (2/5 patients).

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  • (PMID = 18178607.001).
  • [ISSN] 1460-2407
  • [Journal-full-title] Molecular human reproduction
  • [ISO-abbreviation] Mol. Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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74. McMinn J, Wei M, Schupf N, Cusmai J, Johnson EB, Smith AC, Weksberg R, Thaker HM, Tycko B: Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. Placenta; 2006 Jun-Jul;27(6-7):540-9
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  • We measured the ratio of mRNA from a maternally expressed imprinted gene, PHLDA2, to that from a paternally expressed imprinted gene, MEST, by Northern blotting in 38 IUGR-associated placentae and 75 non-IUGR placentae and found an increase in the PHLDA2/MEST mRNA ratio in IUGR (p=0.0001).
  • Altered expression of PHLDA2 and MEST was not accompanied by changes in DNA methylation within their imprinting centers, and immunohistochemistry showed PHLDA2 protein appropriately restricted to villous and intermediate cytotrophoblast in the IUGR placentae.
  • In this series six imprinted genes were differentially expressed by ANOVA with a Benjamini-Hochberg false discovery rate of 0.05, with increased expression of PHLDA2 and decreased expression of MEST, MEG3, GATM, GNAS and PLAGL1 in IUGR placentae.
  • [MeSH-minor] Adult. Blotting, Northern. Blotting, Southern. Female. Gene Expression Profiling. Humans. Oligonucleotide Array Sequence Analysis. Pregnancy. RNA, Messenger / metabolism

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  • (PMID = 16125225.001).
  • [ISSN] 0143-4004
  • [Journal-full-title] Placenta
  • [ISO-abbreviation] Placenta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Proteins; 0 / RNA, Messenger; 0 / TSSC3 protein; 0 / mesoderm specific transcript protein
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75. Stroick M, Alonso A, Fatar M, Griebe M, Kreisel S, Kern R, Gaud E, Arditi M, Hennerici M, Meairs S: Effects of simultaneous application of ultrasound and microbubbles on intracerebral hemorrhage in an animal model. Ultrasound Med Biol; 2006 Sep;32(9):1377-82
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  • Microbubble-enhanced sonothrombolysis (MEST) may be an alternative therapeutic option in ischemic stroke.
  • Clinical study of the efficacy of MEST as an adjunct stroke therapy, before imaging with CT or MRI, requires experimental data on the safety of this approach in the presence of hemorrhagic stroke.
  • This finding provides support for the use of MEST as an early stroke therapy.

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  • (PMID = 16965978.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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76. Hiura H, Obata Y, Komiyama J, Shirai M, Kono T: Oocyte growth-dependent progression of maternal imprinting in mice. Genes Cells; 2006 Apr;11(4):353-61
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  • Here, we analyzed the methylation of DMR for each eight imprinted genes (Igf2r, Lit1, Zac1, Snrpn, Peg1/Mest, Impact, Meg1/Grb10, and H19) by bisulfite sequencing methylation assay, using oocytes from 10 dpp (days post partum), 15 dpp, 20 dpp, and adult mice.
  • More than 85% of DMR methylation was achieved for both Igf2r, Zac1 & Lit1 with oocyte size of reaching 55 microm and Snrpn, Peg1/Mest, Impact, and Meg1/Grb10 with oocyte size of reaching 60 microm.
  • Preferential methylation of maternal allele was observed in Zac1 and Peg1/Mest of juvenile oocytes and in Snrpn of juvenile and adult oocytes.
  • The size-dependent-methylation was also recognized in the growing oocytes collected from adult mice, although the progress is slightly slower than that of juvenile mice.
  • [MeSH-minor] Alleles. Animals. Autoantigens / genetics. Cell Cycle / physiology. Cell Cycle Proteins / genetics. DNA / genetics. DNA / metabolism. DNA Methylation. Female. GRB10 Adaptor Protein / genetics. Genes, Tumor Suppressor. Mice. Mice, Inbred C57BL. Mice, Inbred DBA. Proteins / genetics. Ribonucleoproteins, Small Nuclear / genetics. Transcription Factors / genetics. snRNP Core Proteins

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  • (PMID = 16611239.001).
  • [ISSN] 1356-9597
  • [Journal-full-title] Genes to cells : devoted to molecular & cellular mechanisms
  • [ISO-abbreviation] Genes Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Cell Cycle Proteins; 0 / Grb10 protein, mouse; 0 / Impact protein, mouse; 0 / Plagl1 protein, mouse; 0 / Proteins; 0 / Ribonucleoproteins, Small Nuclear; 0 / Transcription Factors; 0 / mesoderm specific transcript protein; 0 / snRNP Core Proteins; 151441-47-3 / GRB10 Adaptor Protein; 9007-49-2 / DNA
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77. Ya'u J, Yaro AH, Abubakar MS, Anuka JA, Hussaini IM: Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract. J Ethnopharmacol; 2008 Nov 20;120(2):255-8
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  • The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ)-induced convulsion in mice and maximal electroshock test (MEST) in chicks, with benzodiazepine and phenytoin as standard drugs, respectively.
  • Carissa edulis exhibited dose-dependent inhibition of the convulsion induced by MEST with 20mg/kg providing 90% protection while phenytoin (20mg/kg) produced 100% protection.
  • [MeSH-minor] Administration, Oral. Animals. Chickens. Disease Models, Animal. Dose-Response Relationship, Drug. Female. Flumazenil / pharmacology. Injections, Intraperitoneal. Lethal Dose 50. Male. Mice. Naloxone / pharmacology. Phenytoin / pharmacology. Plant Bark. Plant Roots. Toxicity Tests, Acute

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  • (PMID = 18822365.001).
  • [ISSN] 0378-8741
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Plant Extracts; 36B82AMQ7N / Naloxone; 40P7XK9392 / Flumazenil; 6158TKW0C5 / Phenytoin
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78. Sansom SN, Hébert JM, Thammongkol U, Smith J, Nisbet G, Surani MA, McConnell SK, Livesey FJ: Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap. Development; 2005 Sep;132(17):3947-61
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  • One such gene, Mest, was predicted by those studies to be a direct target of Fgf8 signalling and to be involved in setting up, rather than implementing, the progenitor cell protomap.
  • In support of this, we confirmed Mest as a direct transcriptional target of Fgf8-regulated signalling in vitro.

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  • (PMID = 16079153.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 064611; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proteins; 0 / Transcription Factors; 0 / mesoderm specific transcript protein; 62031-54-3 / Fibroblast Growth Factors
  • [Other-IDs] NLM/ EMS5311; NLM/ PMC4729368
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79. Luszczki JJ, Czuczwar SJ: Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. Prog Neuropsychopharmacol Biol Psychiatry; 2007 Mar 30;31(2):529-38
Hazardous Substances Data Bank. TIAGABINE .

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  • To characterize the type of interactions between vigabatrin (VGB) and tiagabine (TGB) -- two newer antiepileptic drugs influencing GABA-ergic neurotransmitter system, the isobolographic analysis was used in two experimental models of epilepsy: the maximal electroshock seizure threshold (MEST) test and pentylenetetrazole (PTZ)-induced seizures in mice.
  • Results indicated that VGB and TGB administered separately (i.p.) increased the electroconvulsive threshold in mice, which allowed the calculation of their TID(20) values (threshold increasing doses by 20% over the threshold of control animals) in the MEST test.
  • With isobolography, the combinations of VGB with TGB (at fixed-ratios of 1:3, 1:1 and 3:1) exerted additive interactions in the MEST test in mice.
  • Only the combination of VGB with TGB at the fixed-ratio of 3:1 was additive in the PTZ test.
  • The evaluation of acute adverse-effect potential for all fixed-ratio combinations of VGB with TGB (administered at their TID(20) and ED(50) values from the MEST and PTZ tests) revealed that none of the examined combinations affected motor coordination in the chimney test and altered neuromuscular tone in the grip-strength test in mice.
  • In contrast, VGB in combinations with TGB produced the antinociceptive effects with respect to suppression of acute thermal pain in animals subjected to the hot-plate test.

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  • (PMID = 17204358.001).
  • [ISSN] 0278-5846
  • [Journal-full-title] Progress in neuro-psychopharmacology & biological psychiatry
  • [ISO-abbreviation] Prog. Neuropsychopharmacol. Biol. Psychiatry
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Nipecotic Acids; GR120KRT6K / Vigabatrin; WM5Z385K7T / Pentylenetetrazole; Z80I64HMNP / tiagabine
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80. Kim KP, Thurston A, Mummery C, Ward-van Oostwaard D, Priddle H, Allegrucci C, Denning C, Young L: Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Res; 2007 Dec;17(12):1731-42
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  • Although the maintenance of mouse and primate embryonic stem cells in a pluripotent state has been reported to disrupt the monoallelic expression of several imprinted genes, available data have suggested relatively higher imprint stability in the human equivalents.
  • Half of the genes examined (IPW, H19, MEG3, MEST isoforms 1 and 2, PEG10, MESTIT1, NESP55, ATP10A, PHLDA2, IGF2) showed variable allelic expression between lines, indicating vulnerability to disrupted imprinting.
  • MEST isoform 1, PEG10, and NESP55 showed an association between the variability observed in interline allelic expression status and the DNA methylation of previously identified regulatory regions.
  • [MeSH-minor] Alleles. Animals. Carcinoma, Embryonal / genetics. Cell Line. Cell Line, Tumor. DNA Methylation. Female. Gene Expression Regulation. Humans. Male. Mice

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  • (PMID = 17989250.001).
  • [ISSN] 1088-9051
  • [Journal-full-title] Genome research
  • [ISO-abbreviation] Genome Res.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/E006159/1; United Kingdom / Medical Research Council / / G113/30
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2099582
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81. Prater MR, Blaylock BL, Holladay SD: Combined dermal exposure to permethrin and cis-urocanic acid suppresses the contact hypersensitivity response in C57BL/6N mice in an additive manner. J Photochem Photobiol B; 2005 Jan 14;78(1):29-34
Hazardous Substances Data Bank. PERMETHRIN .

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  • CH was then evaluated by the mouse ear swelling test (MEST) response to oxazolone.
  • Two days after final treatment, mice were sensitized with oxazolone and MEST was performed.
  • Mice receiving five cUCA injections and permethrin topically on cUCA injection day 1 showed up to 93.3% suppression of MEST compared to vehicle control.

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  • (PMID = 15629246.001).
  • [ISSN] 1011-1344
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES 09642-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 509F88P9SZ / Permethrin; G8D26XJJ3B / Urocanic Acid
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82. Ronchetti D, Lionetti M, Mosca L, Agnelli L, Andronache A, Fabris S, Deliliers GL, Neri A: An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma. BMC Med Genomics; 2008;1:37
The Lens. Cited by Patents in .

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  • Conventional statistics were used to test correlations for significance.
  • RESULTS: We identified transcripts specific to six miRNA host genes (CCPG1, GULP1, EVL, TACSTD1, MEST, and TNIK) whose average changes in expression varied at least 2-fold from the mean of the examined dataset.
  • We evaluated the expression levels of the corresponding intronic miRNAs and identified a significant correlation between the expression levels of MEST, EVL, and GULP1 and those of the corresponding miRNAs miR-335, miR-342-3p, and miR-561, respectively.
  • The predicted putative miRNA targets and the transcriptional profiles associated with the primary tumors suggest that MEST/miR-335 and EVL/miR-342-3p may play a role in plasma cell homing and/or interactions with the bone marrow microenvironment.

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  • (PMID = 18700954.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2531129
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83. Coppo R, Cattran D, Roberts Ian SD, Troyanov S, Camilla R, Cook T, Feehally J: The new Oxford Clinico-Pathological Classification of IgA nephropathy. Prilozi; 2010;31(1):241-8
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  • The scheme will likely become known as the OXFORD-MEST scoring system.

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  • (PMID = 20693944.001).
  • [ISSN] 0351-3254
  • [Journal-full-title] Prilozi
  • [ISO-abbreviation] Prilozi
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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84. Tierling S, Souren NY, Gries J, Loporto C, Groth M, Lutsik P, Neitzel H, Utz-Billing I, Gillessen-Kaesbach G, Kentenich H, Griesinger G, Sperling K, Schwinger E, Walter J: Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human. J Med Genet; 2010 Jun;47(6):371-6
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  • Using bisulfite based technologies 10 differentially methylated regions (DMRs) were analysed, including KvDMR1, H19, SNRPN, MEST, GRB10, DLK1/MEG3 IG-DMR, GNAS NESP55, GNAS NESPas, GNAS XL-alpha-s and GNAS Exon1A.
  • The only slightly variable DMR was that of MEST.

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  • (PMID = 19948534.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DLK1 protein, human; 0 / GRB10 protein, human; 0 / H19 long non-coding RNA; 0 / Intercellular Signaling Peptides and Proteins; 0 / KCNQ1OT1 protein, human; 0 / Membrane Proteins; 0 / Potassium Channels, Voltage-Gated; 0 / Proteins; 0 / RNA, Long Noncoding; 0 / RNA, Untranslated; 0 / mesoderm specific transcript protein; 0 / snRNP Core Proteins; 151441-47-3 / GRB10 Adaptor Protein; 9007-49-2 / DNA; EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
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85. Lui JC, Finkielstain GP, Barnes KM, Baron J: An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs. Am J Physiol Regul Integr Comp Physiol; 2008 Jul;295(1):R189-96
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  • In mammals, somatic growth is rapid in early postnatal life but decelerates with age and eventually halts, thus determining the adult body size of the species.
  • For these genes, Igf2, H19, Plagl1, Mest, Peg3, Dlk1, Gtl2, Grb10, Ndn, Cdkn1c, and SLC38a4, the declines show a temporal pattern similar to the decline in growth rate.
  • Contrary to this hypothesis, the methylation status of the promoter regions of Mest, Peg3, and Plagl1 did not change with age.
  • Our findings suggest that a set of growth-regulating imprinted genes is expressed at high levels in multiple tissues in early postnatal life, contributing to rapid somatic growth, but that these genes are subsequently downregulated in multiple tissues simultaneously, contributing to coordinate growth deceleration and cessation, thus imposing a fundamental limit on adult body size.

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  • (PMID = 18448610.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2494817
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86. Spielmann H: The way forward in reproductive/developmental toxicity testing. Altern Lab Anim; 2009 Dec;37(6):641-56
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  • A comparison of the test guidelines for drugs, agrochemicals and industrial chemicals shows that, for historical reasons, significantly different testing strategies are applied.
  • The current status of development and validation of in vitro tests in reproductive toxicology is also critically evaluated.
  • The mouse embryonic stem cell test (mEST) is the most advanced and promising of the in vitro tests.
  • Moreover, promising molecular endpoints have been established in the mEST, including proteomic and toxicogenomic endpoints.
  • In addition, an overview is given on new in vitro reproductive toxicity tests that are currently being developed in the EU FP6 project, ReProTect, since the ReProTect test battery, which covers the essential steps of female and male fertility, implantation and embryotoxicity, holds promise for use as a screening assay for reproductive toxicity testing according to the EU REACH legislation.
  • However, since validated in vitro methods will not be available in the short term, opportunities for the refinement of the standard in vivo tests are discussed, in order to reduce the numbers of animal used in reproductive toxicity testing.
  • Finally, recommendations for toxicity testing in the 21st century call for the harmonisation of test methods across all areas of regulatory testing as a first step.
  • In particular, the implementation of a new 'extended one-generation reproductive toxicity study' (EOGRTS), which includes triggers for additional testing for fertility, developmental neurotoxicity and immunotoxicity, would significantly reduce test animal numbers.
  • It is concluded that in vitro methods hold great promise for reproductive toxicity testing in the 21st century, e.g. the ReProTect in vitro battery and the embryonic stem cell (ESC) technology focusing on molecular endpoints in both the mEST and the hEST.
  • [MeSH-major] Animal Testing Alternatives / methods. Growth and Development / drug effects. Mutagenicity Tests / methods. Reproduction / drug effects. Toxicity Tests / methods

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  • [Copyright] 2009 FRAME.
  • (PMID = 20105000.001).
  • [ISSN] 0261-1929
  • [Journal-full-title] Alternatives to laboratory animals : ATLA
  • [ISO-abbreviation] Altern Lab Anim
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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87. Large MC, Al-Ahmadie H, Shalhav AL, Zorn KC: Mixed epithelial stromal renal tumor with dystrophic ossification: a case report and literature review. Can J Urol; 2009 Jun;16(3):4690-3
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  • [Title] Mixed epithelial stromal renal tumor with dystrophic ossification: a case report and literature review.
  • The lesion was resected by laparoscopic partial nephrectomy revealing a mixed epithelial and stromal tumor (MEST).
  • This tumor has unusual features including the extensive amount of dystrophic calcification and the young age at presentation.
  • [MeSH-major] Kidney Neoplasms / surgery. Laparoscopy. Neoplasms, Glandular and Epithelial / surgery. Nephrectomy / methods. Ossification, Heterotopic / surgery
  • [MeSH-minor] Adult. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 19497183.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 22
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88. Liu JH, Zhu JQ, Liang XW, Yin S, Ola SI, Hou Y, Chen DY, Schatten H, Sun QY: Diploid parthenogenetic embryos adopt a maternal-type methylation pattern on both sets of maternal chromosomes. Genomics; 2008 Feb;91(2):121-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we show that the maternally imprinted genes Snrpn and Peg1/Mest were nearly unmethylated or heavily methylated, respectively, in their differentially methylated regions (DMRs) at the two-cell stage in parthenogenetic embryos.
  • However, both genes were gradually de novo methylated, with almost complete methylation of all CpG sites by the morula stage in parthenogenetic embryos.
  • Peg3 showed seemingly normal methylation patterns at the two-cell and morula stages, but was also strongly de novo methylated in parthenogenetic blastocysts.

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  • (PMID = 18036775.001).
  • [ISSN] 1089-8646
  • [Journal-full-title] Genomics
  • [ISO-abbreviation] Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Kruppel-Like Transcription Factors; 0 / Peg3 protein, mouse; 0 / Proteins; 0 / Rasgrf1 protein, mouse; 0 / Ribonucleoproteins, Small Nuclear; 0 / mesoderm specific transcript protein; 0 / ras-GRF1; 0 / snRNP Core Proteins
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89. Bischoff SR, Tsai S, Hardison N, Motsinger-Reif AA, Freking BA, Nonneman D, Rohrer G, Piedrahita JA: Characterization of conserved and nonconserved imprinted genes in swine. Biol Reprod; 2009 Nov;81(5):906-20
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  • Using Affymetrix Porcine GeneChip microarrays and/or semiquantitative PCR, brain, fibroblast, liver, and placenta of Day 30 fetuses were profiled, and 25 imprinted genes were identified as differentially expressed in at least one of the four tissue types: AMPD3, CDKN1C, COPG2, DHCR7, DIRAS3, IGF2 (isoform specific), IGF2AS, IGF2R, MEG3, MEST, NAP1L5, NDN, NNAT, OSBPL1A, PEG3, APEG3, PEG10, PLAGL1, PON2, PPP1R9A, SGCE, SLC38A4, SNORD107, SNRPN, and TFPI2.
  • Imprinting was confirmed for DIRAS3, DLK1, H19, IGF2AS, NNAT, MEST, PEG10, PHLDA2, PLAGL1, SGCE, and SNORD107.

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  • (PMID = 19571260.001).
  • [ISSN] 1529-7268
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD048510; United States / NICHD NIH HHS / HD / HD048510
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2770020
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90. Shaw L, Johnson PA, Kimber SJ: Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim; 2010 Feb;46(2):155-65
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  • [Title] Gene expression profiling of the developing mouse kidney and embryo.
  • We have assayed up to 19 candidate genes in eight embryonic tissues at five gestation stages of the mouse embryo to identify markers definitively expressed by renal cells during metanephric induction and markers developmentally regulated during kidney maturation.
  • Results show Dcn, Hoxc9, Mest, Wt1 and Ywhaq were expressed at moderate to high levels during the window of metanephric specification and early differentiation (E10.5-E12.5 dpc), and Hoxc9, Ren1 and Wt1 expression was characteristic of mature renal cells.
  • We demonstrated Cd24a, Cdh11, Mest, Scd2 and Sim2 were regulated during brain development, and Scd2, Cd24a and Sip1 expression was enriched in developing liver.
  • These markers may be useful negative markers of kidney development.
  • [MeSH-major] Embryo, Mammalian / metabolism. Embryonic Development / genetics. Gene Expression. Kidney / embryology

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  • (PMID = 19998061.001).
  • [ISSN] 1543-706X
  • [Journal-full-title] In vitro cellular & developmental biology. Animal
  • [ISO-abbreviation] In Vitro Cell. Dev. Biol. Anim.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Genetic Markers
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91. Marques CJ, Francisco T, Sousa S, Carvalho F, Barros A, Sousa M: Methylation defects of imprinted genes in human testicular spermatozoa. Fertil Steril; 2010 Jul;94(2):585-94

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To study the methylation imprinting marks of two oppositely imprinted genes, H19 and MEST/PEG1, in human testicular spermatozoa from azoospermic patients with different etiologies.
  • Regarding the MEST gene, all patients presented complete unmethylation although this was statistically significantly reduced in the anejaculation group.
  • [MeSH-minor] Adult. Binding Sites / genetics. Biopsy. Humans. Male. Proteins / genetics. RNA, Long Noncoding. RNA, Untranslated / genetics. Spermatogenesis / genetics. Vas Deferens / abnormalities. Vas Deferens / pathology. Young Adult

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  • [Copyright] Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19338988.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / H19 long non-coding RNA; 0 / Proteins; 0 / RNA, Long Noncoding; 0 / RNA, Untranslated; 0 / mesoderm specific transcript protein
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92. Tveden-Nyborg PY, Alexopoulos NI, Cooney MA, French AJ, Tecirlioglu RT, Holland MK, Thomsen PD, D'Cruz NT: Analysis of the expression of putatively imprinted genes in bovine peri-implantation embryos. Theriogenology; 2008 Oct 15;70(7):1119-28
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  • This study reports original data on the expression pattern of 8 putatively imprinted genes (Ata3, Dlk1, Gnas, Grb10, Magel2, Mest-1, Ndn and Sgce) in bovine peri-implantation embryos.
  • Among the 8 genes investigated, only Mest-1 showed differential expression in Day 21 parthenogenetic embryos compared to in vivo and IVP counterparts, indicating maternal imprinting of this gene.

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  • (PMID = 18675451.001).
  • [ISSN] 0093-691X
  • [Journal-full-title] Theriogenology
  • [ISO-abbreviation] Theriogenology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Gasior M, Yankura J, Hartman AL, French A, Rogawski MA: Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose. Epilepsia; 2010 Aug;51(8):1385-94
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  • METHODS: Mice were treated with 2-DG or 3-MG and the seizure threshold determined in the 6-Hz test, the mouse electroshock seizure threshold (MEST) test, and the intravenous pentylenetetrazol (i.v.
  • KA) seizure threshold tests.
  • RESULTS: 2-DG (125-500 mg/kg, i.p., 30 min before testing) significantly elevated the seizure threshold in the 6-Hz seizure test.
  • 2-DG (250-500 mg/kg) decreased the threshold in the MEST and i.v.
  • PTZ and i.v. KA tests.
  • 3-MG had no effect on seizure threshold in the 6-Hz test but, like 2-DG, decreased seizure threshold in the i.v. PTZ test.
  • CONCLUSIONS: Although 2-DG protects against seizures in the 6-Hz seizure test, it promotes seizures in some other models.

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  • [Copyright] Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.
  • (PMID = 20491877.001).
  • [ISSN] 1528-1167
  • [Journal-full-title] Epilepsia
  • [ISO-abbreviation] Epilepsia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Antimetabolites; 0 / Blood Glucose; 9G2MP84A8W / Deoxyglucose; SIV03811UC / Kainic Acid; TZP1275679 / 3-Hydroxybutyric Acid; WM5Z385K7T / Pentylenetetrazole
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94. Ferraro TN, Golden GT, Dahl JP, Smith GG, Schwebel CL, MacDonald R, Lohoff FW, Berrettini WH, Buono RJ: Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. Epilepsia; 2007 Sep;48(9):1667-77
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  • A gene transfer strategy involving a bacterial artificial chromosome (BAC) DNA construct that contains several candidate genes from the critical interval was used to test the hypothesis that a strain-specific variation in one (or more) of the genes is responsible for the QTL effect.
  • Seizure susceptibility was quantified by measuring maximal electroshock seizure threshold (MEST) in transgenic mice and nontransgenic littermates.
  • RESULTS: Seizure testing documented significant MEST elevation in all three transgenic lines compared to littermate controls.

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  • (PMID = 17521350.001).
  • [ISSN] 0013-9580
  • [Journal-full-title] Epilepsia
  • [ISO-abbreviation] Epilepsia
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS040554
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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95. Apostolidou S, Abu-Amero S, O'Donoghue K, Frost J, Olafsdottir O, Chavele KM, Whittaker JC, Loughna P, Stanier P, Moore GE: Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight. J Mol Med (Berl); 2007 Apr;85(4):379-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The expression levels of four imprinted genes, the paternally expressed insulin growth factor 2 (IGF2), the mesoderm-specific transcript isoform 1 (MEST); the maternally expressed pleckstrin homology-like domain, family A, member 2 (PHLDA2); and the polymorphically imprinted insulin-like growth factor 2 (IGF2R) gene are all known to have roles in fetal growth and were studied in the placentae of 200 white European, normal term babies.
  • The quantitative expression analysis with real-time PCR showed the maternally expressing PHLDA2 but not the paternally expressing IGF2 and MEST, nor the polymorphic maternally expressing IGF2R placental levels to have a statistically significant effect on birth weight.

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  • (PMID = 17180344.001).
  • [ISSN] 0946-2716
  • [Journal-full-title] Journal of molecular medicine (Berlin, Germany)
  • [ISO-abbreviation] J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / TSSC3 protein
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96. Hammoud SS, Purwar J, Pflueger C, Cairns BR, Carrell DT: Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility. Fertil Steril; 2010 Oct;94(5):1728-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTERVENTION(S): The CpG methylation patterns were examined at seven imprinted loci sequenced: LIT1, MEST, SNRPN, PLAGL1, PEG3, H19, and IGF2.
  • When comparing the severity of methylation alterations among infertile patients, the oligozoospermic patients were significantly affected at mesoderm-specific transcript (MEST), whereas abnormal protamine patients were affected at KCNQ1, overlapping transcript 1 (LIT1), and at small nuclear ribonucleoprotein polypeptide N (SNRPN).

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  • [Copyright] Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19880108.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / IGF2 protein, human; 0 / KCNQ1OT1 protein, human; 0 / Kruppel-Like Transcription Factors; 0 / PEG3 protein, human; 0 / Potassium Channels, Voltage-Gated; 0 / Protamines; 0 / Proteins; 0 / SNRPN protein, human; 0 / mesoderm specific transcript protein; 0 / snRNP Core Proteins; 67763-97-7 / Insulin-Like Growth Factor II; 9007-49-2 / DNA
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97. Agarwal R, Levinson AW, Schowinsky J, Su LM: Large mixed epithelial and stromal tumor of the kidney masquerading as metastatic renal cell carcinoma. Urology; 2007 Nov;70(5):1008.e17-9
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  • [Title] Large mixed epithelial and stromal tumor of the kidney masquerading as metastatic renal cell carcinoma.
  • Surgical extirpation of the renal mass and liver lesions was performed laparoscopically with the pathological analysis revealing a rare renal neoplasm--mixed epithelial and stromal tumor of the kidney--and adenomas of the liver.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 18068474.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Poole RL, Baple E, Crolla JA, Temple IK, Mackay DJ: Investigation of 90 patients referred for molecular cytogenetic analysis using aCGH uncovers previously unsuspected anomalies of imprinting. Am J Med Genet A; 2010 Aug;152A(8):1990-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Methylation analysis was performed at 13 imprinted loci [PLAGL1, IGF2R, MEST, GRB10, H19, IGF2 DMR2 (IGF2P0), KCNQ1OT1 (KvDMR), MEG3, SNRPN, PEG3, GNAS (GNAS exon 1a and NESP55) and GNASAS].
  • [MeSH-minor] Adolescent. Adult. Child, Preschool. Cohort Studies. Cytogenetic Analysis. Female. Humans. Male

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  • (PMID = 20635366.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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99. Saferali A, Grundberg E, Berlivet S, Beauchemin H, Morcos L, Polychronakos C, Pastinen T, Graham J, McNeney B, Naumova AK: Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines. Epigenetics; 2010 Jan 1;5(1):50-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To determine the effect of cell immortalization and culture on DNA methylation profiles, we analyzed methylation in the differentially methylated regions (DMR) of five imprinted domains: the intergenic (IG) DMR on chromosome 14q32; potassium voltage-gated channel, KQT-like subfamily, member 1, (KCNQ1); small nuclear ribonucleoprotein polypeptide N (SNRPN), mesoderm specific transcript homolog (MEST); and H19 in lymphoblastoid cell lines (LCLs).
  • Using a generalized linear mixed model to compare methylation profiles, we show that recently derived LCLs significantly differ from the CEPH LCLs.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Line. Chromosomes, Human, Pair 14. Gene Expression Profiling. Gene Expression Regulation. Gene Silencing. Genetic Variation. Humans. Middle Aged

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  • (PMID = 20026906.001).
  • [ISSN] 1559-2308
  • [Journal-full-title] Epigenetics
  • [ISO-abbreviation] Epigenetics
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Lee D, Lee Y: The Korea national research resource center. Biopreserv Biobank; 2009 Sep;7(3):137-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The Korea National Research Resource Center (KNRRC) is supported by the Ministry of Education, Science, and Technology (MEST) and consists of 33 research resource centers (RRCs), 5 core centers, and a head office.

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  • (PMID = 24835879.001).
  • [ISSN] 1947-5535
  • [Journal-full-title] Biopreservation and biobanking
  • [ISO-abbreviation] Biopreserv Biobank
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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