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1. Medina EA, Arias VL: [Middle ear adenoma]. Biomedica; 2009 Sep;29(3):348-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Middle ear adenoma].
  • [Transliterated title] Adenoma del oído medio.
  • Middle ear neoplasms are rare lesions and difficult to diagnose due to limited information about their biology and the lack of standard criteria for their analysis.
  • Herein, a middle ear neoplasm is described that became apparent because of its appearance in the external ear duct as it protruded from the middle ear through the eardrum.
  • Following resection, the specimen was determined to be a benign epithelial tumor.
  • Absence of adequate clinical information complicated the diagnosis; therefore,histochemistry and immunohistochemistry analyses were necessary to reach the final diagnosis of middle ear adenoma.
  • [MeSH-major] Adenoma. Ear Neoplasms. Ear, Middle

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  • (PMID = 20436986.001).
  • [ISSN] 0120-4157
  • [Journal-full-title] Biomédica : revista del Instituto Nacional de Salud
  • [ISO-abbreviation] Biomedica
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Colombia
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2. Saliba I, Evrard AS: Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series. Cases J; 2009;2:6508

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series.
  • INTRODUCTION: Middle ear glandular neoplasms are infrequent causes of a middle ear mass.
  • Herein, we present a new case of a middle ear glandular neoplasm.
  • Our objective is to review all cases described in the literature in order to identify the clinical features, the gross pathology, the histopathology, the immunohistochemistry, to discuss the differential diagnosis, the treatment, the rate of recurrence, the follow-up, the incidence of metastasis, the prognosis and to present a new classification of middle ear glandular neoplasm.
  • RESULTS: Ninety-four patients with a middle ear adenoma are included in this report.
  • We uncovered 75 patients with a carcinoid tumor and 19 patients with a middle ear adenoma diagnosis; the most common presenting symptom was a conductive hearing loss.
  • Middle ear adenomas are lesions that are typically white, gray or reddish brown.
  • The tumor's cells are immunohistochemically positive for a variety of keratin antibodies and most of them are also positive for neuroendocrine markers.
  • CONCLUSIONS: Our study and the review of the literature showed adenomas and carcinoid tumors of the middle ear to be essentially indistinguishable benign tumors with metastatic potential.

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  • (PMID = 20111612.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC2812983
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3. Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, Xu H, Ha UH, Xu H, Li JD: Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. PLoS One; 2007 Oct 10;2(10):e1032
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice.
  • The deubiquitinating enzyme cylindromatosis (CYLD), loss of which was originally reported to cause a benign human syndrome called cylindromatosis, has been identified as a key negative regulator for NF-kappaB in vitro.
  • Our data demonstrated that CYLD is induced by NTHi in the middle ear and lung of mice.

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  • (PMID = 17925880.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC004562; United States / NIDCD NIH HHS / DC / R01 DC005843; United States / NIDCD NIH HHS / DC / DC004562; United States / NIDCD NIH HHS / DC / DC005843
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / TNF Receptor-Associated Factor 6; 0 / TRAF7 protein, human; 0 / Traf7 protein, mouse; 0 / Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; EC 3.1.2.15 / CYLD protein, mouse; EC 3.4.22.- / Cysteine Endopeptidases
  • [Other-IDs] NLM/ PMC2001183
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4. Strehl MA, Scheich M, Ott I, Müller-Hermelink HK, Hagen R, Völker HU: [Middle ear adenoma/middle ear carcinoid--an unproblematic tumor?]. Laryngorhinootologie; 2009 Mar;88(3):186-90
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Middle ear adenoma/middle ear carcinoid--an unproblematic tumor?].
  • [Transliterated title] Mittelohradenom/Mittelohrkarzinoid--ein unproblematischer Tumor?
  • OBJECTIVES: Adenomas/carcinoid tumors of the middle ear are very rare tumors of young to middle aged patients.
  • The terms adenoma and carcinoid tumor of the middle ear can be used as synonyms, with the WHO favouring the term middle ear adenoma (MEA).
  • They are classified as benign tumors with only very few reported cases of regional metastasis after years of disease.
  • METHODS AND PATIENTS: This study describes the clinical course and the diagnostic challenges in four cases of this rare tumor entity.
  • In two cases a tumor recurrence was documented with one case recurring six times.
  • The histological differential diagnosis can also be problematic; in one case with a highly atypical morphology it was impossible to arrive at a definite diagnosis during the analysis of a frozen section.
  • CONCLUSION: Adenomas of the middle ear can have a much more complicated clinical course than is suggested by the recent literature.
  • The presented cases in this study and the analysis of previously published cases shows that the typical progression described by the current WHO-classification with unproblematic surgical management of the tumor and an uncomplicated further clinical course does not always correspond to reality.
  • [MeSH-major] Adenoma / diagnosis. Carcinoid Tumor / diagnosis. Ear Neoplasms / diagnosis. Ear, Middle
  • [MeSH-minor] Adult. Cholesteatoma, Middle Ear / diagnosis. Cholesteatoma, Middle Ear / pathology. Cholesteatoma, Middle Ear / surgery. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / surgery. Otoscopy. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 19065497.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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5. Topal O, Erbek SS, Erbek S: Schwannoma of the external auditory canal: a case report. Head Face Med; 2007;3:6
Genetic Alliance. consumer health - Schwannoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannoma of the external auditory canal: a case report.
  • BACKGROUND: Schwannomas are uncommon benign tumors of the external auditory canal.
  • The clinical features, the differential diagnosis, and the surgical treatment of these lesions are discussed.
  • CASE PRESENTATION: A 51-year-old patient presented with a mass obliterating the external auditory meatus.
  • Diagnosis was reported to be schwannoma by histopathologic examination.
  • CONCLUSION: Schwannoma, rarely seen in the external auditory canal, can be managed by a precise excision of the tumor via transmeatal approach.
  • [MeSH-major] Ear Neoplasms / surgery. Neurilemmoma / surgery
  • [MeSH-minor] Audiometry, Pure-Tone. Biopsy. Diagnosis, Differential. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17224070.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1797166
  • [General-notes] NLM/ Original DateCompleted: 20070808
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6. Hwang HS, Lee WJ, Lim HK, Chun HK, Ahn GH: Chondrolipoma in the pelvic cavity: a case report. Korean J Radiol; 2008 Nov-Dec;9(6):563-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A chondrolipoma is an extremely rare form of a benign mesenchymal tumor containing mature cartilage and fatty tissue.
  • [MeSH-major] Chondroma / diagnosis. Lipoma / diagnosis. Mesenchymoma / diagnosis. Pelvic Neoplasms / diagnosis
  • [MeSH-minor] Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19039275.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627234
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7. Onal C, Yuksel O, Topkan E, Pehlivan B: Bilateral glomus tumor treated with PET-CT based conformal radiotherapy: a case report. Cases J; 2009;2:8402

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral glomus tumor treated with PET-CT based conformal radiotherapy: a case report.
  • INTRODUCTION: Glomus tumors are benign, slow growing tumors originating from paraganglionic tissue, mostly located at the carotid bifurcation, jugular foramen, cervical portion vagus nerve, and middle ear cavity.
  • CASE PRESENTATION: We present a 53-year-old female patient with a glomus tumor treated with positron emission tomography computed tomography planning and 3D conformal radiotherapy, and the patient has remained free of disease progression 2 years after.
  • CONCLUSION: It is suggested that radiotherapy is a good treatment modality in patients with glomus tumor, and metabolic imaging and treatment planning with positron emission tomography computed tomography is superior to other imaging modalities.

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  • (PMID = 19918426.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769436
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8. Berns S, Pearl G: Middle ear adenoma. Arch Pathol Lab Med; 2006 Jul;130(7):1067-9
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for middle ear adenoma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Middle ear adenoma.
  • Middle ear adenoma is a benign tumor of the middle ear that can have exocrine (mucinous) and/or neuroendocrine differentiation.
  • Early authors described a separate tumor with predominantly neuroendocrine differentiation as a middle ear carcinoid tumor, but these are now known to be the same tumor.
  • We review the literature of this tumor, including the clinical presentation, gross pathology, histopathology, immunohistochemistry, differential diagnosis, and prognosis.
  • [MeSH-major] Adenoma / pathology. Ear Neoplasms / pathology. Ear, Middle
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Neurilemmoma / diagnosis. Papilloma / diagnosis. Paraganglioma / diagnosis. Prognosis

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  • (PMID = 16831038.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 11
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9. Saruya S, Nagamine H, Komiya T, Ito S, Iino Y, Kodera K, Imamura T: [Immunohistochemical and clinical features of patients with benign middle ear tumors]. Nihon Jibiinkoka Gakkai Kaiho; 2007 May;110(5):403-9
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Immunohistochemical and clinical features of patients with benign middle ear tumors].
  • The middle ear is a rare site for benign tumors.
  • We report six patients with benign middle ear tumors surgicaly removed: three with carcinoid, one with adenoma, and two with paraganglioma.
  • These tumors showed similar histological features in trabecular and glandular architecture, so further immunohistochemical study was needed to make a definitive histopathological diagnosis.
  • For a definitive diagnosis, it is necessary to conduct exploratory tympanotomy or removal of the tumors to obtain enough specimen for histological and immunohistochemical studies.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Ear Neoplasms / pathology. Ear, Middle. Paraganglioma / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 17564130.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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10. Zehlicke T, Punke C, Boltze C, Pau HW: Transient facial palsy in two cases of benign, very rare middle ear tumors (carcinoid tumor and myxoma). Neurologist; 2008 Jan;14(1):52-5
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient facial palsy in two cases of benign, very rare middle ear tumors (carcinoid tumor and myxoma).
  • OBJECTIVE: Presentation of the clinical features of 2 very rare middle ear tumors in which the guiding symptom was facial palsy.
  • MATERIAL AND METHODS: Illustrative case reports about a myxoma and a carcinoid tumor of the middle ear associated with peripheral facial palsy.
  • Moreover, both tumor entities are typically found in organs other than the ear; if located in the middle ear, those neoplasms grow rather superficially.
  • In those cases, a surgical exposure of the middle ear is indicated.
  • If the facial weakness starts together with symptoms suggesting an inflammatory process, the differential diagnosis may be focused first on diseases like herpes zoster oticus and a severe course of acute purulent otitis media.
  • We report the cases of 2 rare middle ear tumors causing facial palsy.
  • [MeSH-major] Carcinoid Tumor / pathology. Ear Neoplasms / pathology. Ear, Middle / pathology. Facial Paralysis / pathology. Myxoma / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Facial Nerve / pathology. Facial Nerve / physiopathology. Hearing Loss / etiology. Hearing Loss / pathology. Hearing Loss / radiography. Herpes Zoster Oticus / diagnosis. Humans. Male. Mastoid / pathology. Mastoid / radiography. Mastoid / surgery. Middle Aged. Neurosurgical Procedures. Otitis Media / diagnosis. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / radiography. Tomography, X-Ray Computed. Treatment Outcome. Vertigo / etiology. Vertigo / pathology. Vertigo / radiography

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  • (PMID = 18195660.001).
  • [ISSN] 1074-7931
  • [Journal-full-title] The neurologist
  • [ISO-abbreviation] Neurologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Ferlito A, Devaney KO, Rinaldo A: Primary carcinoid tumor of the middle ear: a potentially metastasizing tumor. Acta Otolaryngol; 2006 Mar;126(3):228-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary carcinoid tumor of the middle ear: a potentially metastasizing tumor.
  • The concept of a carcinoid tumor in the gastrointestinal tract and lung is well established; less often, patients develop carcinoid tumors in the head and neck region.
  • One particularly uncommon site of origin of carcinoid tumors in the head and neck area is the middle ear.
  • Middle ear carcinoids have previously been approached as benign entities, lacking any capacity for metastasizing.
  • A critical review of the literature, however, disclosed a small number of cases in which middle ear carcinoid tumors have given rise to regional (cervical node) metastases.
  • This in turn suggests that, as is the case with pulmonary carcinoid tumors, middle ear carcinoids should be thought of as low-grade malignancies which, while relatively slow-growing, nevertheless possess a limited capacity for spreading to regional lymph nodes.
  • To date, distant metastases have not been associated with middle ear carcinoid tumors.
  • [MeSH-major] Carcinoid Tumor / secondary. Ear Neoplasms / pathology. Ear, Middle. Lymphatic Metastasis / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Immunohistochemistry. Male. Neoplasm Staging. Prognosis. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 16618645.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 21
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12. Olszewski J, Konopka W, Radek A, Zieliński K, Pietkiewicz P: [Middle ear schwannoma--case report]. Otolaryngol Pol; 2005;59(6):907-10
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  • [Title] [Middle ear schwannoma--case report].
  • Schwannoma is one of the common benign middle ear space tumors.
  • The tumors may present with facial nerve paresis or palsy, otologic symptoms and/or parotid mass middle ear schwannomas may originate from the nerves of the tympanic caviti or by extensions from outside the middle ear space.
  • We present the clinical and radiologic features of a middle-space schwannoma originating from facial nerve.
  • The patient underwent middle ear exploration and mastoidectomy.
  • The tumor was of facial nerve origin and was separated from middle ear.
  • The pathologic diagnosis was schwannoma.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, Middle / pathology. Neurilemmoma / pathology

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  • (PMID = 16521463.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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13. Bogomilsky MR, Turusov DA, Kushel IuV, Zelikovich EI, Poliaev IuA: [Glomus tumors of the middle ear in children]. Vestn Otorinolaringol; 2007;(5):4-7
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  • [Title] [Glomus tumors of the middle ear in children].
  • Glomus tumor (GT) is a rare tumor of the middle ear in children.
  • In spite of cytologically benign nature of this tumor, its course can be characterized as malignant because of GT infiltrative growth, destruction of the adjacent bone tissue, possible intracranial involvement.
  • Because of scare symptoms, early GT diagnosis is problematic.
  • At admission to hospital principal complaints of the children are poor hearing, discharge from the ear.
  • GT of the middle ear are detected with application of computed tomography which is able to show changes in the soft tissue and bone destruction, and angiography.
  • GT treatment planning depends on the examination data and can include radiotherapy, endovascular occlusion of the vessels carrying blood to the tumor, surgical treatment and combination of the methods.
  • Modern approaches to GT diagnosis and treatment are described.
  • A case of GT of the temporal bone with involvement of the middle cranial fossa in a 4-year-old child is reported.
  • [MeSH-major] Ear Neoplasms / epidemiology. Ear Neoplasms / pathology. Ear, Middle / pathology. Glomus Tumor / epidemiology. Glomus Tumor / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 18163069.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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14. Zehlicke T, Punke C, Haase K, Boltze C, Pau HW: [Myxoma of the middle ear-a rare cause of facial palsy]. HNO; 2008 Feb;56(2):165-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Myxoma of the middle ear-a rare cause of facial palsy].
  • [Transliterated title] Das Myxom des Mittelohrs als mögliche Ursache einer temporären Fazialisparese.
  • In case of the co-occurrence of facial palsy and inflammation-like symptoms of the same ear, the differential diagnosis is focused on viral (herpes zoster) or bacterial diseases.
  • We report a patient for whom the surgical exploration of the middle ear revealed a benign tumor: a myxoma.
  • The typical tumor site is the atrium of heart.
  • In the ear, the tumor grows slowly and remains asymptomatic unless it irritates structures such as the facial nerve or the vestibular organ.
  • Histologically, the tumor presents a "myxoid" matrix that is rich in acid mucopolysaccarides.
  • Using the case presented, we discuss the causality between the tumor and the facial palsy, although during the operation the bony canal of the nerve was found to be intact.
  • In any cases with clinically and radiologically unclear findings of the ear in connection with facial palsy, surgical exposure should be considered.
  • [MeSH-major] Ear Neoplasms / complications. Ear, Middle. Facial Paralysis / etiology. Myxoma / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Herpes Zoster Oticus / diagnosis. Humans. Male. Mastoid / surgery. Otitis Externa / diagnosis. Otoscopy. Tomography, X-Ray Computed

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  • [Cites] HNO. 1969 Apr;17 (4):113-5 [5405595.001]
  • [Cites] Head Neck. 1996 Sep-Oct;18(5):459-64 [8864738.001]
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  • (PMID = 17115088.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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15. Kojima H, Yaguchi Y, Moriyama H: Middle ear hemangiona: a case report. Auris Nasus Larynx; 2008 Jun;35(2):255-9
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  • [Title] Middle ear hemangiona: a case report.
  • A middle ear hemangioma was detected in a 51-year-old man who suffered from fullness and hearing loss in the left ear.
  • The mass was surgically resected for diagnostic and therapeutic reasons, and pathologic examination revealed a benign hemangioma.
  • The CT, MRI, angiography, and light microscopy findings of the tumor are documented and compared with those a glomus tumor.
  • The significance of this diagnosis is also discussed.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear, Middle. Hemangioma / diagnosis
  • [MeSH-minor] Cerebral Angiography. Humans. Magnetic Resonance Imaging, Interventional. Male. Middle Aged

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  • (PMID = 17851004.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 16
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16. Wiatr M, Składzień J: [Benign tumors of the external and middle ear from data collected at the Otolaryngologyst Department of the Jagiellonian University in Cracow between 1992-2001]. Przegl Lek; 2007;64(12):1004-5

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  • [Title] [Benign tumors of the external and middle ear from data collected at the Otolaryngologyst Department of the Jagiellonian University in Cracow between 1992-2001].
  • 26 patients with benign tumors of the external and middle ear were treated at the Otolaryngology Department of the Jagiellonian University in Cracow between 1992-2001.
  • Benign tumors of the external and middle ear are rare diseases, and it is usually easy to establish final diagnosis.
  • In our population the most common tumor was osteoma located in external ear canal.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, External / surgery. Ear, Middle / surgery. Osteoma / surgery

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  • (PMID = 18595503.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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17. Angouridakis N, Hytiroglou P, Markou K, Bouzakis A, Vital V: Middle ear adenoma/carcinoid tumour: a case report and review of the literature. Rev Laryngol Otol Rhinol (Bord); 2009;130(3):199-202
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  • [Title] Middle ear adenoma/carcinoid tumour: a case report and review of the literature.
  • Middle ear adenoma, a rare benign tumour with glandular and neuroendocrine differentiation, originates from the epithelial lining of the middle ear.
  • CASE REPORT: We report a case of a 52-year-old woman, who presented with progressive hearing loss and fullness in the left ear for 3 months.
  • Clinical examination revealed a mass in the left middle ear.
  • Histological examination revealed tumour cells forming gland-like and cribriform structures, as well as compact groups.
  • On immunohistochemical staining, the tumour cells were positive for epithelial (cytokeratins, epithelial membrane antigen) and neuroendocrine (neuron specific enolase, synaptophysin, chromogranin and pancreatic polypeptide) markers.
  • CONCLUSION: Middle ear adenoma is a benign tumour that is treated by complete surgical removal.
  • The immunohistochemical staining of the present case supports the suggestion that this tumour is best described by the term neuroendocrine adenoma of the middle ear.
  • [MeSH-major] Adenoma. Carcinoid Tumor. Ear Neoplasms. Ear, Middle
  • [MeSH-minor] Female. Humans. Middle Aged

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  • (PMID = 20345079.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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18. Sumi T, Tsunoda A, Shirakura S, Kishimoto S: Mechanical obstruction of the eustachian tube by the benign tumor of the parapharyngeal space does not cause otitis media with effusion. Otol Neurotol; 2007 Dec;28(8):1072-5
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  • [Title] Mechanical obstruction of the eustachian tube by the benign tumor of the parapharyngeal space does not cause otitis media with effusion.
  • OBJECTIVE: We are reporting on eustachian tube and middle ear pathologic findings in patients with parapharyngeal tumors.
  • PATIENTS: Eleven cases of eustachian tube involvement as indicated by obstruction due to compression of the tumor were assessed in this study.
  • RESULTS: All of the tumors were diagnosed benign according to the histologic examination.
  • In 9 of the 11 patients, the pharyngeal opening of the eustachian tube narrowed or was blocked by the tumor.
  • None of the patients showed any response on the tumor side in the sonotubometry.
  • Therefore, gas exchange was prevented through the eustachian tube by the tumor; however, they also showed an intact tympanic membrane and normal hearing tests.
  • CONCLUSION: According to our data, if there is drainage of middle ear fluid through the eustachian tube and the exchange of gas in the middle ear is preserved, otitis media with effusion will not occur even in cases such as these.
  • [MeSH-minor] Acoustic Impedance Tests. Adult. Audiometry, Pure-Tone. Ear, Middle / physiology. Female. Functional Laterality / physiology. Humans. Magnetic Resonance Imaging. Nasopharynx / pathology. Otoscopy. Tomography, X-Ray Computed. Tympanic Membrane / physiology

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  • (PMID = 18084819.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Sanna M, Fois P, Pasanisi E, Russo A, Bacciu A: Middle ear and mastoid glomus tumors (glomus tympanicum): an algorithm for the surgical management. Auris Nasus Larynx; 2010 Dec;37(6):661-8
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  • [Title] Middle ear and mastoid glomus tumors (glomus tympanicum): an algorithm for the surgical management.
  • OBJECTIVE: Glomus tumors are slow-growing benign lesions and represent the most common primary neoplasms of the middle ear.
  • METHODS: Between December 1988 and July 2008, 68 patients with histologically confirmed glomus tympanicum tumor underwent surgical treatment.
  • Nineteen patients with larger Class B tumors underwent a subtotal petrosectomy with blind sac closure of the external auditory canal and middle ear obliteration.
  • Gross total tumor removal was achieved in all 68 cases.
  • CONCLUSION: Surgical excision of glomus tympanicum tumors is a safe procedure, allowing total tumor removal with minimal morbidity, a low recurrence rate, and a low complication rate.
  • [MeSH-major] Algorithms. Ear Neoplasms / surgery. Ear, Middle. Glomus Tympanicum Tumor / surgery. Mastoid. Skull Neoplasms / surgery. Surgical Procedures, Operative
  • [MeSH-minor] Adult. Aged. Audiometry. Female. Follow-Up Studies. Hearing Loss / diagnosis. Hearing Loss / etiology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Otologic Surgical Procedures. Postoperative Period. Reoperation. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome. Tympanic Membrane Perforation / etiology. Young Adult

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20400250.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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20. Emodi O, El-Naaj IA, Gordin A, Akrish S, Peled M: Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma). J Oral Maxillofac Surg; 2010 Sep;68(9):2092-8
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  • [Title] Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma).
  • PURPOSE: Of all benign salivary gland tumors of the parotid gland, pleomorphic adenoma (mixed tumor) is the most common.
  • It accounts for 60% to 70% of all benign tumors of the parotid gland.
  • This neoplasm arises in patients in the fourth to sixth decade of life, with a female predominance.
  • The purpose of our study is to compare 2 surgical techniques performed at the Ear, Nose, and Throat and Maxillofacial Departments, Rambam Medical Center, Haifa, Israel, and determine which is preferable in treating this lesion.
  • [MeSH-minor] Adolescent. Adult. Aged. Chi-Square Distribution. Child. Facial Nerve Injuries / etiology. Female. Humans. Male. Middle Aged. Retrospective Studies. Statistics, Nonparametric. Sweating, Gustatory / etiology. Young Adult

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  • [Copyright] Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20728030.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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21. Rydzewski B, Goździcka-Józefiak A, Sokalski J, Matusiak M, Durzyński L: [Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms]. Otolaryngol Pol; 2007;61(2):137-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms].
  • There's a hypothesis, that it plays a significant role in middle ear chronic inflammations and neoplasm's.
  • The examination was carried on a group of 53 patients, 39 of which was suffering from granulation tissue chronic otitis media, 7-cholesteatomatous otitis media, 6--middle ear malignant neoplasm, and 1 middle and/or external ear benign neoplasm.
  • The material was postoperative tissue, like polyps, inflammatory granulation tissue, cholesteatoma masses and malignant neoplasm's tissue.
  • In every case of middle ear malignant neoplasm a presence of high-risk DNA Papilloma types 16 or 18 was confirmed.
  • CONCLUSIONS: The results has been compared with other authors examinations and it is claimed that they confirm the observation, that Human Papilloma Viruses may be a factor, that might play an important role in pathology of chronic otitis media and ear neoplasm's.
  • It is concluded, that differences in percentages of HPV presence in chronic inflammations (70%) and ear neoplasm's may be explained by viral co-infection during bacterial c. o. m.
  • [MeSH-major] Ear / virology. Ear Neoplasms / virology. Papilloma / genetics. Papilloma / virology. Papillomavirus Infections / diagnosis. Tumor Virus Infections / diagnosis. Tumor Virus Infections / virology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Cholesteatoma, Middle Ear / epidemiology. Cholesteatoma, Middle Ear / virology. Female. Humans. Male. Middle Aged. Otitis Media / epidemiology. Otitis Media / virology. Poland / epidemiology. Polymerase Chain Reaction. Prognosis

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  • (PMID = 17668798.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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22. Tubbs RS, Kelly DR, Pugh JL, Loukas M, Oakes WJ: Benign fibrous histiocytoma of the skull base. Case report. J Neurosurg; 2007 Jan;106(1 Suppl):65-7
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  • [Title] Benign fibrous histiocytoma of the skull base. Case report.
  • The authors report the case of benign fibrous histiocytoma (BFH) of the skull base in an 11-month-old girl.
  • During draining for a middle ear infection, the child was noted to have an anomalous mass in the skull base.
  • At the most recent follow-up examination--18 months postoperatively--the child was noted to be asymptomatic with no gross increase in tumor size.
  • [MeSH-major] Histiocytoma, Benign Fibrous / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Female. Follow-Up Studies. Humans. Infant. Occipital Bone / pathology. Occipital Bone / surgery. Temporal Bone / pathology. Temporal Bone / surgery

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  • (PMID = 17233317.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Kloek CE, Bilyk JR, Pribitkin EA, Rubin PA: Orbital decompression as an alternative management strategy for patients with benign tumors located at the orbital apex. Ophthalmology; 2006 Jul;113(7):1214-9
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  • [Title] Orbital decompression as an alternative management strategy for patients with benign tumors located at the orbital apex.
  • The purpose of this study was to investigate outcomes in 5 patients with benign-appearing but symptomatic tumors located in the intraconal portion of the orbital apex in which orbital decompression was performed as an alternative management strategy to resection.
  • PARTICIPANTS: Five patients were diagnosed with a compressive optic neuropathy secondary to a benign-appearing tumor at the orbital apex.
  • None of the patients had the tumor biopsied or resected.
  • CONCLUSIONS: Orbital decompression is a therapeutic option for patients with compressive optic neuropathies from benign orbital apex tumors, offering potential improvement in optic nerve function while sparing morbidity from attempts at surgical resection.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Color Perception. Female. Humans. Male. Middle Aged. Ophthalmologic Surgical Procedures. Retrospective Studies. Tomography, X-Ray Computed. Visual Acuity. Visual Fields

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  • [CommentIn] Ophthalmology. 2007 Mar;114(3):619-20; author reply 620-1 [17324707.001]
  • (PMID = 16815404.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Sciarretta V, Pasquini E, Frank G, Modugno GC, Cantaroni C, Mazzatenta D, Farneti G: Endoscopic treatment of benign tumors of the nose and paranasal sinuses: a report of 33 cases. Am J Rhinol; 2006 Jan-Feb;20(1):64-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic treatment of benign tumors of the nose and paranasal sinuses: a report of 33 cases.
  • BACKGROUND: The endoscopic approach can be used successfully for the treatment of benign tumors such as fibroosseous and vascular lesions, pleomorphic adenoma, glioma, meningioma, and schwannoma.
  • METHODS: Thirty-three patients diagnosed with benign tumors of the nasal cavity and paranasal sinuses and treated using an endoscopic approach were reviewed retrospectively.
  • The endoscopic approach was simple in 28 cases and associated with an external approach in 5 cases (because of an intracranial extension of the tumor in four patients and its location at the level of the anterior wall of the frontal sinus in the last case).
  • CONCLUSION: In selected cases, endoscopic surgery can be considered an effective treatment for the resection of benign tumors involving the sinonasal tract.
  • [MeSH-minor] Adolescent. Adult. Aged. Angiofibroma / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Glioma / surgery. Hemangioma, Cavernous / surgery. Humans. Magnetic Resonance Imaging. Male. Meningioma / surgery. Middle Aged. Osteoma / surgery. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16539297.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review.
  • INTRODUCTION: Primary neoplasms of the external ear canal are rare, and 5% of these tumors are of glandular origin.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • An alternative theory holds that pleomorphic adenomas may well arise from ectopic salivary tissue present in the external ear canal.
  • These tumors are very rare and usually have a benign course.
  • In this report, we describe an unusual case of pleomorphic adenoma of the external auditory canal associated with chronic infection of the middle ear.
  • Subsequent biopsy and histologic examination revealed pleomorphic adenoma of the external ear canal, possibly with malignant elements.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Earache / etiology. Female. Humans. Mastoid / surgery. Middle Aged. Otitis Media / etiology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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26. Okada K, Ito K, Yamasoba T, Ishii M, Iwasaki S, Kaga K: Benign mass lesions deep inside the temporal bone: imaging diagnosis for proper management. Acta Otolaryngol Suppl; 2007 Dec;(559):71-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign mass lesions deep inside the temporal bone: imaging diagnosis for proper management.
  • CONCLUSION: Among mass lesions inside the temporal bone, benign tumors and cholesteatomas can be differentiated by contrast enhancement in T1-weighted images (T1WI) and by diffusion-weighted images (DWI).
  • OBJECTIVES: To review the imaging characteristics of mass lesions inside the temporal bone and to investigate pertinent imaging modalities for differential diagnosis, which is crucial for appropriate treatment planning.
  • RESULTS: One patient had facial schwannoma, two had glomus jugulare tumor, and three had cholesteatoma.
  • MRI study provided us with better clues: contrast enhancement on T1WI was observed only in benign tumors and only cholesteatomas showed high intensity on DWI.
  • [MeSH-major] Cholesteatoma, Middle Ear. Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / surgery. Facial Nerve. Glomus Jugulare Tumor / diagnosis. Granuloma / diagnosis. Granuloma / surgery. Mucocele / diagnosis. Neurilemmoma / diagnosis. Neurilemmoma / surgery. Temporal Bone
  • [MeSH-minor] Angiography. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18340574.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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27. Shekarkhar MJ, Tabei SZ, Kumar PV, Hashemi SB: Cytologic findings in calcifying epithelial odontogenic tumor: a case report. Acta Cytol; 2005 Sep-Oct;49(5):533-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic findings in calcifying epithelial odontogenic tumor: a case report.
  • BACKGROUND: Calcifying epithelial odontogenic tumor (CEOT), or Pindborg's tumor, is a rare, benign, odontogenic neoplasm first described by Pindborg in 1955.
  • CASE: A 62-year-old woman was referred to the ear, nose and throat clinic with a right maxillary mass.
  • CONCLUSION: FNA findings of calcifying epithelial odontogenic tumor have been described rarely.
  • The clusters of epithelial cells with prominent nucleoli are mistaken for features of a malignant tumor.
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Diagnostic Errors / prevention & control. Female. Humans. Maxilla / pathology. Maxilla / radiography. Maxillary Sinus / pathology. Maxillary Sinus / radiography. Middle Aged. Palate, Hard / pathology. Palate, Hard / radiography

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  • (PMID = 16334032.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Kuczkowski J, Izycka-Swieszewska E, Plichta Ł, Cieszyńska J: [Combined tumor of ceruminous gland origin in the external auditory canal--a histopathological and immunohistochemical study]. Otolaryngol Pol; 2010 Nov-Dec;64(6):385-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combined tumor of ceruminous gland origin in the external auditory canal--a histopathological and immunohistochemical study].
  • OBJECTIVES: We present a case of a combined tumor consisting of solid tubular gland adenoma (TA) and syringocystadenoma papilliferum (SCAP) of the external auditory canal and review of the literature on this subject.
  • METHODS: Tumour of the external auditory canal was removed by retroauricular approach with good clinical outcome.
  • RESULTS: In the histopathological assessment tumour revealed an extraordinary combination of syringocystadenoma papilliferum and ceruminous tubular gland adenoma pattern.
  • CONCLUSIONS: Tubular gland adenoma and syringocystadenoma papilliferum are benign tumors originating from ceruminous glands of the skin, characterized by very rare occurrence especially in the skin of the external auditory canal.
  • Every tumor arising from the external auditory canal should be examined histologically and immunohistochemically in order to choose the best treatment option.
  • [MeSH-major] Adenoma / pathology. Cerumen. Ear Neoplasms / pathology. Ear, External / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 21302507.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Cheung FM, Lau TW, Cheung LK, Li AS, Chow SK, Lo AW: Schneiderian papillomas and carcinomas: a retrospective study with special reference to p53 and p16 tumor suppressor gene expression and association with HPV. Ear Nose Throat J; 2010 Oct;89(10):E5-E12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schneiderian papillomas and carcinomas: a retrospective study with special reference to p53 and p16 tumor suppressor gene expression and association with HPV.
  • Schneiderian papillomas are uncommon benign tumors of the sinonasal area.
  • For each case, we documented the morphology, immunohistochemical expression of tumor suppressor genes p53 and p16, and any association with human papillomavirus (HPV) infection as detected by either polymerase chain reaction or in situ hybridization techniques.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Papilloma, Inverted / genetics. Papilloma, Inverted / metabolism. Papilloma, Inverted / pathology. Papilloma, Inverted / virology. Papillomavirus Infections / epidemiology. Polymerase Chain Reaction. Retrospective Studies

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  • (PMID = 20981655.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Pérez-Guillermo M, Acosta-Ortega J, García-Solano J, Ramos-Freixá J: Cytologic aspect of brown tumor of hyperparathyroidism. Report of a case affecting the hard palate. Diagn Cytopathol; 2006 Apr;34(4):291-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic aspect of brown tumor of hyperparathyroidism. Report of a case affecting the hard palate.
  • The cytologic and histologic findings of one brown tumor (BT) of hyperparathyroidism located in the hard palate, at first misdiagnosed as peripheral giant-cell granuloma, are described.
  • Poor communication between cytopathologist and ear nose and throat specialist was responsible for the error.
  • MGC-rich aspirates pose the same diagnostic dilemmas as those of histologic sections of MGC-containing lesions of bone: these cells are not diagnostic by themselves and can be seen in several benign and malignant conditions.
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnostic Errors. Giant Cells / pathology. Humans. Male. Middle Aged

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  • (PMID = 16544338.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Sadetzki S, Chetrit A, Freedman L, Stovall M, Modan B, Novikov I: Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis. Radiat Res; 2005 Apr;163(4):424-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis.
  • Our aims were to assess the risk of radiation-induced malignant brain tumors and benign meningiomas after childhood exposure and to investigate the role of potential modifiers of that risk.
  • Survival analysis using Poisson regression was performed to estimate the excess relative and absolute risks (ERR, EAR) for brain tumors.
  • After a median follow-up of 40 years, an ERR/Gy of 4.63 and 1.98 (95% CI = 2.43-9.12 and 0.73-4.69) and an EAR/Gy per 10(4) PY of 0.48 and 0.31 (95% CI = 0.28-0.73 and 0.12-0.53) were observed for benign meningiomas and malignant brain tumors, respectively.
  • The estimated ERR/Gy for malignant brain tumors decreased with increasing age at irradiation from 3.56 to 0.47 (P = 0.037), while no trend with age was seen for benign meningiomas.
  • The ERR for both types of tumor remains elevated at 30-plus years after exposure.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Causality. Child. Child, Preschool. Cohort Studies. Comorbidity. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Incidence. Infant. Israel / epidemiology. Longitudinal Studies. Male. Middle Aged. Radiation Dosage. Risk Factors. Sex Distribution


32. Bambakidis NC, Rodrigue T, Megerian CA, Ratcheson RA: Endolymphatic sac tumor metastatic to the spine. Case report. J Neurosurg Spine; 2005 Jul;3(1):68-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endolymphatic sac tumor metastatic to the spine. Case report.
  • Although histologically benign, they may exhibit invasive growth and destruction of the skull base.
  • Patients generally present with symptoms referable to the lesion's location within the middle or posterior cranial fossa.
  • [MeSH-major] Adenoma / etiology. Ear Neoplasms / pathology. Endolymphatic Sac. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Female. Humans. Lumbar Vertebrae. Middle Aged

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  • (PMID = 16122027.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Choufani G, Roper N, Delbrouck C, Hassid S, Gabius HJ: Animal model for cholesteatoma induced in the gerbil: will the profiles of differentiation/growth-regulatory markers be similar to the clinical situation? Laryngoscope; 2007 Apr;117(4):706-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Cholesteatoma is a benign tumor of the middle ear characterized by an aggressive and invasive potential.
  • MATERIAL AND METHODS: We have induced cholesteatoma by surgical ligature of the gerbil's external auditory duct.

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  • (PMID = 17415142.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Galectins; 0 / Macrophage Migration-Inhibitory Factors; 0 / Receptors, Retinoic Acid; 0 / retinoic acid receptor alpha; 0 / retinoic acid receptor beta; 0 / retinoic acid receptor gamma
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34. Miller JP, Semaan M, Einstein D, Megerian CA, Maciunas RJ: Staged Gamma Knife radiosurgery after tailored surgical resection: a novel treatment paradigm for glomus jugulare tumors. Stereotact Funct Neurosurg; 2009;87(1):31-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: Although benign and slow growing, glomus jugulare tumors can be locally aggressive because of their proximity to lower cranial nerves and major vascular structures.
  • We report a novel treatment paradigm of tailored surgical resection followed by staged radiosurgery that allows for tissue diagnosis and immediate improvement of symptoms and tumor control without the morbidity of radical surgical resection.
  • METHODS: Five patients with glomus jugulare tumors and contraindications to extensive surgery each underwent an outpatient otologic procedure to resect the portion of the tumor in the middle ear and mastoid with no attempt to remove tumor in the jugular bulb.
  • Each patient returned 2-5 months later for Gamma Knife radiosurgery to the remainder of the tumor, which consisted of one 15-Gy dose prescribed to the 50% isodose curve.
  • Tumor volume was stable or reduced in all patients at most recent follow-up, and there were no immediate or delayed complications.
  • CONCLUSIONS: Staged outpatient microsurgical and radiosurgical therapy for glomus jugulare tumors in the symptomatic patient is safe and yields favorable results regarding tumor size, tinnitus, hearing and cranial nerve status.
  • [MeSH-major] Ear Neoplasms / surgery. Glomus Jugulare Tumor / surgery. Models, Anatomic. Radiosurgery / methods. Reoperation / methods. Skull Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 19174618.001).
  • [ISSN] 1423-0372
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
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35. Agrawal Y, Clark JH, Limb CJ, Niparko JK, Francis HW: Predictors of vestibular schwannoma growth and clinical implications. Otol Neurotol; 2010 Jul;31(5):807-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We evaluated the extent to which tumor growth influences the management of these benign tumors, and we explored symptom markers present at diagnosis that may be predictive of tumor growth.
  • MAIN OUTCOME MEASURE(S): Tumor growth, defined as a 1 mm/year or greater increase in tumor size.
  • RESULTS: We observed that tumor growth was the most important predictor of a change in treatment strategy from serial observation to microsurgical or radiosurgical treatment.
  • We further noted in multivariate analyses that larger tumor size at diagnosis was associated with higher odds of tumor growth, such that each 1-mm increment in tumor size at presentation increased the odds of growth by 20%.
  • We also found that the symptom marker of tinnitus at diagnosis significantly increased the odds of tumor growth nearly 3-fold.
  • CONCLUSION: Tumor growth plays a significant role in guiding the management of vestibular schwannomas.
  • Assessment of tumor size at diagnosis and for the presence of tinnitus may allow for risk stratification of patients with newly diagnosed vestibular schwannomas and for a more rational application of the conservative management approach.
  • [MeSH-major] Ear Neoplasms / pathology. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Female. Humans. Male. Microsurgery. Middle Aged. Odds Ratio. Otologic Surgical Procedures. Predictive Value of Tests. Radiosurgery. Retrospective Studies. Tinnitus / etiology

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  • (PMID = 20502379.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Zhang F, Wang Y, Dai C, Chi F, Zhou L, Chen B, Li H: [Clinical experience in facial nerve tumors: a review of 27 cases]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Jan;24(1):4-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To analyze the clinical manifestations and the diagnosis of the facial nerve tumor according to the clinical information, and evaluate the different surgical approaches depending on tumor location.
  • During the course of the disease, 23 patients (85.2%) suffered facial paralysis, both hearing loss and tinnitus affected 11 (40.7%) cases, 5 (18.5%) manifested infra-auricular mass and the others showed some of otalgia or vertigo or ear fullness or facial numbness/twitches.
  • CONCLUSION: Facial nerve tumor is a rare and benign lesion, and has numerous clinical manifestations.
  • CT and MRI can help surgeons to make a right diagnosis preoperatively.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome. Young Adult

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  • (PMID = 20235447.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Barbarino S, McCormick SA, Lauer SA, Milman T: Syringocystadenoma papilliferum of the eyelid. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):185-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To describe 6 patients with syringocystadenoma papilliferum of the eyelid and to review the literature regarding this rare eyelid tumor.
  • METHODS: Clinicopathologic series of 6 cases, diagnosed at the New York Eye and Ear Infirmary from 1990 to 2006.
  • Most cases had a preoperative diagnosis of basal cell carcinoma or cyst.
  • None of the lesions was associated with a malignant neoplasm.
  • Although syringocystadenoma papilliferum of the eyelid can be associated with other benign lesions, no malignant transformation or association with malignant neoplasms has been reported.
  • The evidence suggests that this tumor should be managed with conservative complete excision.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Dermis / pathology. Epidermis / pathology. Eyelids / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 19454927.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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38. Kim HJ, McCormick SA, Nath S, Moskowitz B, Milman T: Melanocytic nevi of the tarsal conjunctiva: clinicopathologic case series with review of literature. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):438-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Clinicopathologic series of 4 cases diagnosed at the New York Eye and Ear Infirmary between January 1990 and April 2009.
  • Biopsy, therefore, is prudent as histopathology alone allows documentation of the benign nature of these lesions.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20683369.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Durden FL Jr, Moore CE, Muller S: Verrucous carcinoma of the paranasal sinuses: a case report. Ear Nose Throat J; 2010 Jul;89(7):E21-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor grows locally invasive but is histologically benign and metastasizes rarely.
  • This case highlights the difficulty of pathologic diagnosis and management options for a rare neoplastic lesion.
  • [MeSH-minor] Biopsy. Endoscopy. Humans. Male. Middle Aged. Nasal Cavity / pathology. Nasal Cavity / radiation effects. Nasal Cavity / surgery. Neoplasm Invasiveness. Neoplasm Staging. Orbital Neoplasms / pathology. Orbital Neoplasms / radiotherapy. Orbital Neoplasms / surgery. Skull / pathology. Skull / radiation effects. Skull / surgery. Skull Neoplasms / pathology. Skull Neoplasms / radiotherapy. Skull Neoplasms / surgery

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  • (PMID = 20628974.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. De Gabory L, Deminière C, Stoll D: [Immunohistochemistry expression of 3 markers (CEA, UEA-I and Ki-67) in nasal inverted papillomas]. Rev Laryngol Otol Rhinol (Bord); 2008;129(3):159-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Expression immunohistochimique de l'ACE, de l'UEA-I et du Ki-67 dans les papillomes inversés naso-sinusiens.
  • OBJECTIVES: Immunohistochemistry evaluation of the expression of degeneration and proliferation markers of the benign form of Schneiderian inverted papillomas in the ORL sphere, in the nondysplastic, dysplastic and degenerated forms.
  • MATERIALS AND METHOD: 44 surgical specimens were analyzed in two groups: A= 33 benign and B= 11 degenerated.
  • A simultaneous bipolar localization belonged to the two groups (nasal, benign and otologic malignant).
  • But, no difference existed between groups A and B, the various sub-groups and the benign specific localizations.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / analysis. Ki-67 Antigen / analysis. Nose Neoplasms / pathology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / pathology. Plant Lectins / analysis. Sphenoid Sinus / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Child. Diagnosis, Differential. Ear Neoplasms / pathology. Ear Neoplasms / surgery. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Nasal Mucosa / pathology. Nasal Polyps / pathology. Nasal Polyps / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Prognosis. Reference Values

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  • (PMID = 19694158.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Ki-67 Antigen; 0 / Plant Lectins; 0 / Ulex europaeus lectins
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41. de Ru JA, van Leeuwen MS, van Benthem PP, Velthuis BK, Sie-Go DM, Hordijk GJ: Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors? J Oral Maxillofac Surg; 2007 May;65(5):945-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Prospectively, 99 patients with 77 benign and 22 malignant lesions were included; 82 underwent parotidectomy.
  • On PE, the location of the tumor was predicted.
  • Various characteristics and the presumed diagnosis were assessed.
  • Furthermore, the location of the tumor in relation to the facial nerve was predicted.
  • Cytology correctly predicted the benign or malignant nature of the tumor in all cases.
  • CONCLUSION: FNAC is the only accurate investigation for classifying a parotid gland tumor as benign or malignant.
  • Palpation and MRI are superior to US in predicting tumor location.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve / anatomy & histology. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Staging / methods. Parotid Gland / anatomy & histology. Parotid Gland / innervation. Physical Examination. Reference Standards. Single-Blind Method

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  • (PMID = 17448846.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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42. Boulos PR, Knoepp SM, Rubin PA: Green bone. Arch Ophthalmol; 2007 Mar;125(3):380-6
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  • OBJECTIVE: To describe the unusual finding of yellow-green-colored bone during routine orbital surgery, to detail its investigation, and to demonstrate its benign nature.
  • RESULTS: Yellow-green bone was encountered in 3 patients during orbital tumor excision or orbital fracture repair procedures.
  • In all cases, absence of neoplasia was demonstrated histologically.
  • [MeSH-minor] Adult. Color. Humans. Male. Microscopy, Fluorescence. Microscopy, Ultraviolet. Middle Aged. Orbital Fractures / surgery. Orbital Neoplasms / radiography. Orbital Neoplasms / surgery. Spectrophotometry, Ultraviolet. Tomography, X-Ray Computed

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  • (PMID = 17353410.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Synthesis Inhibitors; F8VB5M810T / Tetracycline
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43. Newton JR, Ruckley RW, Earl UM: Laryngeal neurilemmoma: a case report. Ear Nose Throat J; 2006 Jul;85(7):448-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Published reports of benign nerve sheath tumors of the larynx are extremely rare.
  • Because these tumors represent a potential threat to the airway, prompt diagnosis and treatment are vital.
  • We discuss the diagnosis and management of this rare tumor.
  • [MeSH-major] Laryngeal Muscles / pathology. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery
  • [MeSH-minor] Airway Obstruction / prevention & control. Arytenoid Cartilage / pathology. Female. Follow-Up Studies. Humans. Larynx / surgery. Middle Aged. Treatment Outcome

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  • (PMID = 16909818.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Ghanooni R, Decaestecker C, Simon P, Gabius HJ, Hassid S, Choufani G: Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas. Hear Res; 2006 Apr;214(1-2):7-16
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  • Cholesteatoma is a benign disease characterized by the presence of an unrestrained growth and the accumulation of keratin in the middle ear cavity.
  • [MeSH-major] Cholesteatoma, Middle Ear / enzymology. Galectin 3 / analysis. Macrophage Migration-Inhibitory Factors / analysis. Protein Kinase C / analysis. Retinoid X Receptor beta / analysis. Tumor Suppressor Protein p53 / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Blotting, Western. Female. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Male. Middle Aged. Recurrence

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  • (PMID = 16513304.001).
  • [ISSN] 0378-5955
  • [Journal-full-title] Hearing research
  • [ISO-abbreviation] Hear. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Macrophage Migration-Inhibitory Factors; 0 / Retinoid X Receptor beta; 0 / Tumor Suppressor Protein p53; EC 2.7.11.13 / Protein Kinase C
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45. Hox V, Vander Poorten V, Delaere PR, Hermans R, Debiec-Rychter M, Sciot R: Extramammary myofibroblastoma in the head and neck region. Head Neck; 2009 Sep;31(9):1240-4
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  • BACKGROUND: Mammary myofibroblastoma is a benign mesenchymal tumor of the breast.
  • A diagnosis could not be made on CT scans, so the mass was surgically removed.
  • The diagnosis of extramammary myofibroblastoma was made.
  • CONCLUSION: We describe this case because of the unusual location of this rare tumor.
  • [MeSH-minor] Female. Humans. Middle Aged

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  • (PMID = 19132718.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Moser A, Hoffmann KM, Walch C, Sovinz P, Lackner H, Schwinger W, Benesch M, Fritz G, Urban C: Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl. J Pediatr Hematol Oncol; 2008 Dec;30(12):935-7
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  • A 15-year-old girl presented with pain in the right ear and acute onset of total peripheral facial nerve palsy.
  • A first biopsy led to the diagnosis of intracranial giant cell reparative granuloma (GCRG), a rare benign tumor of the bone or soft tissue that can show expansive growth.
  • Total surgical excision revealed a cholesteatoma central to the GCRG originating from the right middle ear and mastoid.
  • [MeSH-major] Bone Diseases / etiology. Cholesteatoma, Middle Ear / complications. Granuloma, Giant Cell / etiology. Temporal Bone

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  • (PMID = 19131785.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 144O8QL0L1 / Diclofenac
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47. Ramina R, Maniglia JJ, Fernandes YB, Paschoal JR, Pfeilsticker LN, Coelho Neto M: Tumors of the jugular foramen: diagnosis and management. Neurosurgery; 2005 Jul;57(1 Suppl):59-68; discussion 59-68
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  • [Title] Tumors of the jugular foramen: diagnosis and management.
  • METHODS: The tumors were approached by a multidisciplinary team composed of neurosurgeons, ear, nose, and throat surgeons, and neuroradiologists.
  • Complete excision was possible in 89% of benign tumors and 80% of paragangliomas.
  • CONCLUSION: Radical removal of benign jugular foramen tumors is the treatment of choice and may be curative.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Embolization, Therapeutic / methods. Glomus Jugulare Tumor / diagnosis. Glomus Jugulare Tumor / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Glomus Jugulare / pathology. Glomus Jugulare / surgery. Humans. Male. Middle Aged. Retrospective Studies. Skull Base Neoplasms. Treatment Outcome

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  • (PMID = 15987570.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Koutsimpelas D, Stripf T, Heinrich UR, Mann WJ, Brieger J: Expression of vascular endothelial growth factor and basic fibroblast growth factor in sporadic vestibular schwannomas correlates to growth characteristics. Otol Neurotol; 2007 Dec;28(8):1094-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Vestibular schwannoma is a benign, slow-growing neoplasm that accounts for 6% of all intracranial tumors.
  • The mRNA expression and the protein expression of both growth factors correlated positive to tumor volume, to tumor growth index, and to MVD.
  • CONCLUSION: The bFGF and VEGF mRNA expression and the bFGF and VEGF protein expression in sporadic VS correlates to the tumour volume, to the tumor growth index, and to the MVD.
  • [MeSH-major] Ear Neoplasms / metabolism. Ear Neoplasms / pathology. Fibroblast Growth Factor 2 / biosynthesis. Neuroma, Acoustic / metabolism. Neuroma, Acoustic / pathology. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Adult. Aged. Antigens, CD31 / biosynthesis. Antigens, CD31 / genetics. Capillaries / pathology. Disease Progression. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neovascularization, Pathologic / genetics. Neovascularization, Pathologic / pathology. RNA, Messenger / analysis. RNA, Messenger / biosynthesis. Regional Blood Flow / physiology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17721409.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
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49. Hirshoren N, Weinberger JM, Neuman T, Ilan O, Ben-Yaakov A: Recurrent vascular leiomyoma of the larynx: clinical and histopathologic characteristics and treatment. Ear Nose Throat J; 2010 Aug;89(8):382-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Laryngeal vascular leiomyomas are uncommon benign tumors that seldom recur following complete excision.
  • The choice of excision procedure-via direct laryngoscopy or an open approach-is dictated by tumor size, the expected amount of blood loss, and any comorbidities the patient may have.
  • [MeSH-major] Angiomyoma / surgery. Laryngeal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Adenoma / surgery. Female. Humans. Laryngoscopy. Larynx / pathology. Laser Therapy. Magnetic Resonance Imaging. Medical Records. Middle Aged. Neoplasms, Multiple Primary / surgery. Parathyroid Neoplasms / surgery. Reoperation. Respiration Disorders / etiology

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  • (PMID = 20737377.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Persaud R, Tudge S, Amonoo-Kuofi K, Beale T, O'Flynn P: Parapharyngeal granular cell tumour: a unique surgical challenge. J Laryngol Otol; 2005 Jan;119(1):68-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parapharyngeal granular cell tumour: a unique surgical challenge.
  • A granular cell tumour is a rare lesion of probable nerve sheath origin.
  • It is typically benign but up to seven per cent may be malignant.
  • Since its original description in the tongue in 1926, the tumour has been reported to occur at many other sites in the body.
  • The authors report a case of a 49-year-old African woman with an oro-naso-parapharyngeal granular cell neoplasm causing mild dysphagia.
  • The location of this tumour, which has not been reported previously, posed a unique surgical challenge.
  • [MeSH-major] Granular Cell Tumor / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Deglutition Disorders / etiology. Female. Humans. Middle Aged. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15807973.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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51. Skrivan J, Zvĕrina E, Kluh J, Chovanec M, Pádr R: Our experience with surgical treatment of tympanojugular pragangliomas. Prague Med Rep; 2010;111(1):25-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tympanojugular paragangliomas are benign and slow growing lesions of the lateral skull base.
  • Treatment modalities include preoperative embolization of feeding vessels and tumour itself, surgical removal and irradiation.
  • Surgical radicality has been achieved in 62.5%, in the rest of patients the tumour remnants were either irradiated with a Leksell gamma knife, or left without treatment in a wait-end-rescan approach.
  • According to the benign character of the tumour, radicality is not always the highest goal, since a radical removal may be compromised by a high postoperative morbidity.
  • [MeSH-major] Ear Neoplasms / surgery. Glomus Jugulare Tumor / surgery. Paraganglioma, Extra-Adrenal / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 20359435.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
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52. Yaşar H, Ozkul H, Verim A, Ilhan E, Kökten N, Dereci G: [An evaluation of parotid gland masses]. Kulak Burun Bogaz Ihtis Derg; 2007;17(2):70-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathological diagnoses were benign in 33 patients (66%), malignant in nine patients (18%), and tumor-like pathologies in eight patients (16%), the most common being pleomorphic adenoma (n=28, 56%), Warthin's tumor (n=4, 8%), and squamous cell carcinoma (n=4, 8%).
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Parotid Diseases / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / epidemiology. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Parotid Neoplasms / diagnosis. Parotid Neoplasms / epidemiology. Parotid Neoplasms / etiology. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Retrospective Studies. Turkey / epidemiology

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  • (PMID = 17527056.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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53. Fussell JN, Cooke ER, Florentino F, Sheehan DJ: Atypical fibroxanthoma with keloidal collagen. Am J Dermatopathol; 2010 Oct;32(7):713-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Collagen Type I / biosynthesis. Histiocytoma, Benign Fibrous / pathology. Procollagen / biosynthesis. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diabetes Mellitus. Ear / pathology. Humans. Hypertension / complications. Immunohistochemistry. Kidney Failure, Chronic / complications. Male. Middle Aged. Neprilysin / biosynthesis. Renal Dialysis

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  • (PMID = 20700041.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / Procollagen; EC 3.4.24.11 / Neprilysin
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54. Jakobiec FA, Bhat P, Colby KA: Immunohistochemical studies of conjunctival nevi and melanomas. Arch Ophthalmol; 2010 Feb;128(2):174-83
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  • OBJECTIVE: To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations.
  • Results for HMB-45 were negative in the middle and lower subepithelial portions of 18 of 20 lesions; it was usually only weakly positive within the superficial junctional zone.
  • CONCLUSIONS: S-100 and MART-1 were not useful in separating benign from malignant lesions.
  • Immunostaining for HMB-45 and Ki-67 are valuable adjuncts to careful histopathologic evaluation in assessing benign and malignant conjunctival melanocytic tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Conjunctival Neoplasms / diagnosis. Melanoma / diagnosis. Neoplasm Proteins / analysis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD45 / analysis. Antigens, Neoplasm / analysis. Child. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Ki-67 Antigen / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Retrospective Studies. S100 Proteins / analysis. Young Adult

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  • (PMID = 20142539.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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55. Madhumita K, Nambiar A, Prathapan P: Solitary neurofibroma of the palatine tonsil: a case report. Ear Nose Throat J; 2007 Dec;86(12):756-8
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  • We present a rare case of a benign tumor of the tonsil in a 49-year-old woman.
  • The tumor was excised in its entirety, and the patient's postoperative course was uneventful.
  • [MeSH-minor] Female. Humans. Middle Aged

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  • (PMID = 18217382.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Kitahara T, Kubo T, Doi K, Mishiro Y, Kondoh K, Horii A, Okumura S, Miyahara H: [Delayed facial nerve palsy after otologic surgery]. Nihon Jibiinkoka Gakkai Kaiho; 2006 Jul;109(7):600-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Furthermore, DFP was always observed ipsilaterally to the operated ear after otologic surgeries and was never seen after benign parotid tumor surgery or total laryngectomy.
  • [MeSH-minor] Adult. Aged. Child, Preschool. Cochlear Implantation. Endolymphatic Sac. Female. Humans. Male. Middle Aged. Stapes Surgery. Time Factors. Tympanoplasty

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  • (PMID = 16910581.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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57. Durr ML, Agrawal N, Saunders JR, Ha PK: Laryngeal lipoma associated with diffuse lipomatosis: case report and literature review. Ear Nose Throat J; 2010 Jan;89(1):34-7
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  • Lipomas are benign mesenchymal tumors that are often found in the head and neck.
  • The tumor was successfully removed via an endoscopic laser resection.
  • [MeSH-minor] Humans. Male. Middle Aged

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  • (PMID = 20155698.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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58. Lenarz M, Durisin M, Kamenetzki P, Becker H, Kreipe HH, Lenarz T: Cavernous hemangioma of the internal auditory canal. Eur Arch Otorhinolaryngol; 2007 May;264(5):569-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cavernous hemangioma of the internal auditory canal.
  • Hemangiomas rarely occur in the internal auditory canal.
  • The presence of a small contrast-enhancing tumor in the internal auditory canal accompanied by severe sensorineural hearing loss and facial nerve palsy, should raise the suspicion of a hemangioma.
  • Early recognition and surgical intervention in these benign tumors may improve the chance of preserving the functional integrity of the facial nerve and provides better results after nerve reconstruction.
  • Due to their relative small size, the temporal bone CT-scan may show no evidence of pathological widening of the internal auditory canal or the typical intralesional calcifications at the time of presentation.
  • MRI with Gadolinium is the imaging method of choice and a high index of clinical suspicion is necessary for the diagnosis of these tumors.
  • In this paper we report about a 51-year-old male presented with right-sided sensory-neural deafness and facial nerve palsy, accompanied by severe tinnitus and ipsilateral loss of vestibular function due to a cavernous hemangioma in the internal auditory canal.
  • [MeSH-major] Ear, Inner / pathology. Facial Nerve / pathology. Hemangioma, Cavernous / pathology. Peripheral Nervous System Neoplasms / pathology. Vestibulocochlear Nerve / pathology
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • [Cites] Ann Otol Rhinol Laryngol. 2004 Jun;113(6):431-7 [15224824.001]
  • [Cites] Am J Otol. 1992 May;13(3):223-32 [1609850.001]
  • [Cites] Otolaryngol Head Neck Surg. 1989 Jul;101(1):27-32 [2502760.001]
  • [Cites] Otolaryngol Head Neck Surg (1979). 1980 Sep-Oct;88(5):555-9 [6969383.001]
  • (PMID = 17235534.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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59. Kwon H, Kim HY, Jung SN, Sohn WI, Yoo G: Extraskeletal chondroma in the auricle. J Craniofac Surg; 2010 Nov;21(6):1990-1
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for extraskeletal chondroma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extraskeletal chondroma is a rare benign tumor that develops in soft tissues, and histologically, it is a lobulated nodule surrounded by a fibrous capsule, and the inside consists of mature cartilage cells and diffuse hyalinized matrix.
  • [MeSH-major] Chondroma / diagnosis. Ear Auricle / pathology. Ear Neoplasms / diagnosis
  • [MeSH-minor] Calcinosis / pathology. Chondrocytes / pathology. Follow-Up Studies. Humans. Hyalin. Male. Middle Aged

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  • (PMID = 21119479.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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60. Oktay MF, Aşkar I, Yildirim M, Topçu I, Meriç F: Tuberculous parotitis: a review of seven cases. Kulak Burun Bogaz Ihtis Derg; 2007;17(5):272-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All the patients had a clinical suspicion of a parotid gland tumor.
  • Computed tomography or magnetic resonance imaging obtained in five patients showed mass formation suggesting a benign parotid gland tumor.
  • Following diagnosis, all patients were treated with a four-drug chemotherapy regimen.
  • CONCLUSION: Tuberculosis of the parotid gland should be considered in the differential diagnosis of patients presenting with a solitary tumor in the parotid gland.
  • [MeSH-major] Parotitis / diagnosis. Tuberculosis, Oral / diagnosis
  • [MeSH-minor] Adult. Antitubercular Agents / therapeutic use. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18187986.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Antitubercular Agents
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61. Witt RL: Minimally invasive surgery for parotid pleomorphic adenoma. Ear Nose Throat J; 2005 May;84(5):308, 310-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Compared with total parotidectomy and complete superficial parotidectomy for the removal of a parotid pleomorphic adenoma, partial superficial parotidectomy with dissection and preservation of the facial nerve--defined as the excision of a tumor with a 2-cm margin of normal parotid parenchyma except at the point where the tumor abuts the facial nerve--is associated with a lower incidence of transient facial nerve dysfunction, facial contour disfigurement, and subsequent Frey's syndrome.
  • The author hypothesized that the use of this procedure to remove a benign pleomorphic adenoma might result in even less morbidity (transient or permanent facial nerve dysfunction, facial contour disfigurement, Frey's syndrome, and hypoesthesia) without increasing the risk of recurrence if only a 1-cm margin of normal parotid parenchyma was removed and if the posterior branches of the great auricular nerve were preserved To test this hypothesis, the author conducted a retrospective study of 30 patients--15 who had undergone the standard partial procedure (2-cm margin with great auricular nerve sacrifice) and 15 who had undergone the modified version (1-cm margin with great auricular nerve preservation).
  • Although a 1-cm area of normal parotid parenchyma around a benign pleomorphic adenoma was a safe margin, it was no better than a 2-cm margin in terms ofmorbidity and recurrence.
  • [MeSH-minor] Adult. Aged. Endoscopy. Female. Humans. Hypesthesia / epidemiology. Male. Middle Aged. Postoperative Complications / epidemiology. Retrospective Studies

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  • (PMID = 15971755.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Yu H, Liu D, Li C, Huang X, Zhong W: [Clinical application of postauricular muscular fasciae-periosteal flap and modified unwrinkle incision in parotidectomy]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2009 Oct;23(10):1167-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: From January 2006 to August 2008, 28 patients with benign lesions of parotid gland were treated.
  • There were 17 males and 11 females aged 19 to 79 years old (average 50 years old), including 20 cases of mixed tumor, 5 cases of adenolymphoma, 1 case of branchial cleft cyst, 1 case of eosinophilic hyperplastic lymphogranuloma, and 1 case of myoepithelioma.
  • Tumor masses were all prominent, with the diameter of 2.4-3.8 cm and partial-tough texture.
  • Parotid gland and tumor mass were resected with postauricular incision hidden within the hairline, introcession defect (3.0 cm x 2.0 cm x 1.0 cm-3.5 cm x 2.5 cm x 1.5 cm) were repaired with simultaneously adopting postauricular muscular fasciae-periosteal flap (4.0 cm x 3.0 cm x 1.0 cm-5.0 cm x 4.0 cm x 1.5 cm) by turning the pedicle flap 180 degrees.
  • [MeSH-minor] Adult. Aged. Ear, External / surgery. Female. Humans. Male. Middle Aged. Surgical Flaps. Young Adult

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  • (PMID = 19957830.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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63. Uğuz MZ, Onal HK, Eroğlu OO, Etit D: [Sensitivity and specificity of fine needle aspiration biopsy in parotid masses]. Kulak Burun Bogaz Ihtis Derg; 2007;17(2):96-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The results of FNAB were reported as benign in 21 patients (72.4%), malignant in six patients (20.7%), and suspicious in two patients (6.9%).
  • Postoperative histopathologic diagnoses were reported as benign in 17 patients (58.6%) and malignant in 12 patients (41.4%).
  • The most common histopathological diagnosis was pleomorphic adenoma (n=7, 24.1%), followed by mucoepidermoid carcinoma (n=4, 13.8%), and Warthin's tumor (n=3, 10.3%).
  • [MeSH-major] Biopsy, Fine-Needle / standards. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 17527061.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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64. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):589-609, ix-x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / etiology. Headache / epidemiology. Headache / etiology. Humans. Meningitis / epidemiology. Meningitis / etiology. Neoplasm Recurrence, Local. Postoperative Complications. Postural Balance / physiology. Tinnitus / epidemiology. Tinnitus / etiology

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  • (PMID = 17544697.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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65. Trindade F, Haro R, Requena L: Giant angiolymphoid hyperplasia with eosinophilia on the chest. J Cutan Pathol; 2009 Apr;36(4):493-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This rare benign process occurs with a female predominance.
  • Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp.
  • Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear.
  • The lesion is benign but may be persistent and is difficult to eradicate.
  • We report on a case of a 58-year-old Caucasian man who presented a purplish pink dome-shaped tumor of size up to 8 cm in diameter located on the chest.
  • [MeSH-minor] Humans. Male. Middle Aged

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  • (PMID = 19278439.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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66. Vaid L, Gupta M, Gupta N, Singh PP: Bleomycin sclerotherapy in a rare case of adult-onset cervical lymphangioma. Ear Nose Throat J; 2010 Jan;89(1):E23-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cervical lymphangioma in adults is a rare, benign tumor.
  • [MeSH-minor] Female. Humans. Middle Aged. Neck

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  • (PMID = 20155685.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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67. Roche PH, Mercier P, Sameshima T, Fournier HD: Surgical anatomy of the jugular foramen. Adv Tech Stand Neurosurg; 2008;33:233-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Surgical exposure of the JF is usually justified by the removal of benign tumors that grow in this region.
  • In the second step, the external auditory canal is transsected and the intrapetrous facial nerve is mobilized, giving more exposure of the carotid canal and middle ear cavity.
  • Using the same dissection of the soft tissues from a lateral trajectory, these three approaches bring solutions to the radical removal of distinct tumor extensions.

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  • (PMID = 18383816.001).
  • [ISSN] 0095-4829
  • [Journal-full-title] Advances and technical standards in neurosurgery
  • [ISO-abbreviation] Adv Tech Stand Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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68. Fleiner F, Jumah M, Göktas O: Cancer of the external auditory canal-diagnostic and treatment. Indian J Otolaryngol Head Neck Surg; 2009 Dec;61(4):270-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer of the external auditory canal-diagnostic and treatment.
  • BACKGROUND: Ear squamous cell carcinoma (SCC) is a tumor with a poor prognosis, due to a late initial diagnosis because of a concealment by primarily benign symptoms and due to the unfavorable localization including the infiltration of important structures such as the middle ear, mandibular joint or dura.
  • PATIENTS AND METHODS: We retrospectively examined 10 patients, medium age: 63.8 ± 9.3 years between 2002 and 2008 with a histological confirmed SCC of the external auditory canal.
  • CONCLUSION: The prognosis for ear SCC primarily depends on early clinical and histopathological diagnostics and requires a sufficient and standardized staging to determine the therapy involving surgery and radiochemotherapy.

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  • [Cites] Laryngoscope. 1977 Oct;87(10 Pt 1):1622-34 [904397.001]
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  • (PMID = 23120649.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450079
  • [Keywords] NOTNLM ; Carcinoma of the external auditory canal / Prognosis / Radiation treatment / Squamous cell carcinoma / Surgery
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69. Zatonski T, Bolanowski M, Skrzypek A, Morawska-Kochman M, Kaluzny M, Zatonska K, Moron K, Badowski R, Krecicki T: Evaluation of temporal bone computed tomography and paranasal sinuses magnetic resonance images in acromegalic patients. Neuro Endocrinol Lett; 2010;31(6):796-800
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Acromegaly is a rare disease, which symptoms are caused by excess secretion of a growth hormone (GH) from the anterior pituitary benign tumor - adenoma.
  • 2. CT of temporal bone did not reveal structural changes of internal and median ear.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 21206436.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
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70. Archibald DJ, Neff BA, Voss SG, Splinter PL, Driscoll CL, Link MJ, Dong H, Kwon ED: B7-H1 expression in vestibular schwannomas. Otol Neurotol; 2010 Aug;31(6):991-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Little is known about how benign human vestibular schwannomas interact with antibody-mediated or cell-mediated immunity.
  • We report on the aberrant expression of a novel T-cell coregulatory molecule, B7 homolog 1 (B7-H1), in vestibular schwannomas and discuss the implications of B7-H1 expression and tumor aggressiveness and a potential regulator of B7-H1 expression.
  • A clinical review of patient presenting symptoms and tumor characteristics was performed.
  • Failure of tumor control with stereotactic radiation (p = 0.029) was significantly greater in the strongly positive B7-H1 tumors.
  • Although clinical trends were seen, greater statistical power is required to evaluate whether B7-H1 expression correlates with more aggressive tumor growth or poorer hearing class.

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  • (PMID = 20601920.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA134345-03; United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS242934; NLM/ PMC4810681
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71. Kinoshita S, Kakizaki H, Iwaki M, Hara K: [Two cases of dermolipoma]. Nippon Ganka Gakkai Zasshi; 2007 Dec;111(12):965-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Dermolipoma is an uncommon benign tumor, congenitally occurring on the conjunctiva, and may be present at other sites.
  • The appearance of dermolipoma closely resembles orbital fat prolapse and limbal dermoid, and therefore it is necessary to take this into account in diagnosis.
  • Another case, an 8-year-old female patient, was referred for the treatment of a bulbar conjunctival tumor in her left eye.
  • In both cases, dermolipoma was suspected because the tumor did not show in the limbus and it did not change in size even when the eyeball was pressed.
  • There was no external ear anomaly, facial dissymmetry, or cervical abnormality.
  • CONCLUSIONS: If the special features of dermolipoma are understood, it is easy to distinguish this tumor from other disorders.
  • [MeSH-minor] Child. Conjunctival Neoplasms / congenital. Conjunctival Neoplasms / surgery. Female. Humans. Middle Aged

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  • (PMID = 18186219.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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72. Rudic M, Grayeli AB, Cazals-Hatem D, Cyna-Gorse F, Bouccara D, Sterkers O: Temporal bone central giant-cell granuloma presenting as a serous otitis media. Eur Arch Otorhinolaryngol; 2008 May;265(5):587-91
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  • Central giant cell granuloma is a benign intraosseous lesion that most commonly occurs in the facial bones.
  • CT-scan and MRI revealed a temporal bone tumor involving the mastoid, and surrounding the right temporo-mandibular joint.
  • Tumor was totally removed after a canal-wall-down mastoidectomy and middle ear exclusion.
  • [MeSH-major] Bone Diseases / diagnosis. Granuloma, Giant Cell / diagnosis. Otitis Media with Effusion / diagnosis. Temporal Bone

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  • (PMID = 18004584.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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73. Pietniczka-Załeska M, Dabrowska-Bień J: [Parotid tumors: a two-year experience of Otolaryngology Department at MSS Hospital in Warsaw]. Otolaryngol Pol; 2009 Sep;63(7):43-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of the study is to present current epidemiological data, most frequent complains, our surgical technique, histopathological diagnosis, complications rate and follow-up.
  • All of the patients had ultrasound examination prior to operation to estimate the spread and the type of the tumor.
  • RESULTS: The frequency of incidence of benign tumours was 90% and the most frequent histopathological diagnosis was pleomorphic adenoma (49%) and adenolymphoma (42%).
  • The most frequent complication was sensory deficit about the cheek and ear (35%), temporary facial nerve paresis (5%), hematoma (1%), salivary fistula (1%).
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Hospitals, Special. Humans. Male. Middle Aged. Neoplasm Staging. Oral Surgical Procedures / statistics & numerical data. Poland. Retrospective Studies. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20564899.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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74. Scheipers U, Siebers S, Gottwald F, Ashfaq M, Bozzato A, Zenk J, Iro H, Ermert H: Sonohistology for the computerized differentiation of parotid gland tumors. Ultrasound Med Biol; 2005 Oct;31(10):1287-96
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  • It is found in the subcutaneous tissue of the face, overlying the mandibular ramus and anterior and inferior to the external ear.
  • The results of the classification are presented as a numerical score indicating the probability of a certain tumor or alteration for each parotid gland.
  • The receiver operating characteristic curve area is A(ROC) = 0.95 +/- 0.07 when using fourfold cross-validation over cases and differentiating between various benign parotid gland tumors and monomorphic adenoma.
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Adenoma, Pleomorphic / ultrasonography. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fuzzy Logic. Humans. Lymph Nodes / pathology. Lymph Nodes / ultrasonography. Male. Middle Aged. Parotid Diseases / pathology. Parotid Diseases / ultrasonography. Parotid Gland / pathology. Parotid Gland / surgery. Parotid Gland / ultrasonography. Probability. ROC Curve. Sensitivity and Specificity

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  • (PMID = 16223631.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Pérez-Mora RM, Sanchez-Carrion S, Barea FL, Garcia-Raya P, Lassaletta L: Osteoblastoma of the temporal bone. Skull Base; 2009 Sep;19(5):345-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign osteoblastoma is an uncommon primary tumor of the bone.
  • Any area of the skeleton may be affected by this tumor, but its occurrence in the temporal bone and middle ear is extremely rare.
  • Clinical symptoms are nonspecific, even in the middle ear, and the diagnosis is often difficult in spite a complete physical and radiological examination.
  • A biopsy is usually necessary for definitive diagnosis.
  • We report a case of benign osteoblastoma involving the temporal bone and the middle ear and a review of the literature.

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  • [Cites] J Pediatr Surg. 2000 Jul;35(7):1127-9 [10917313.001]
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  • (PMID = 20190944.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765705
  • [Keywords] NOTNLM ; Osteoblastoma / hearing loss / temporal bone / tinnitus
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76. Ileri F, Ceylan A, Uslu S, Asal K: [Isolated inverted papilloma of the sphenoid sinus: a case report]. Kulak Burun Bogaz Ihtis Derg; 2006;16(1):41-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inverted papilloma is a rare benign sinonasal tumor characterized by a potentially invasive nature.
  • Tumor was taken via transnasal endoscopic sphenoidotomy.
  • [MeSH-major] Papilloma, Inverted / diagnosis. Paranasal Sinus Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Endoscopy. Headache / etiology. Humans. Male. Middle Aged. Nasal Obstruction / etiology. Otorhinolaryngologic Surgical Procedures. Sphenoid Sinus / pathology. Sphenoid Sinus / radiography. Tomography, X-Ray Computed

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  • (PMID = 16763414.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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77. Ozluoglu LN, Yilmaz I, Cagici CA, Bal N, Erdogan B: Ganglioneuroma of the internal auditory canal: a case report. Audiol Neurootol; 2007;12(3):160-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ganglioneuroma of the internal auditory canal: a case report.
  • Ganglioneuroma is a rare, benign, slow-growing tumor thought to develop from cells of neural crest origin, even though hypotheses on the pathogenesis of that lesion differ.
  • Magnetic resonance imaging revealed a mass (3 x 4 mm) in the internal auditory canal (IAC).
  • The encapsulated tumor was entirely excised via the middle fossa approach.
  • We suggest that ganglioneuroma be considered in the differential diagnosis of all tumors of the IAC.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, Inner / pathology. Ganglioneuroma / pathology. Magnetic Resonance Imaging
  • [MeSH-minor] Audiometry. Cranial Fossa, Middle / surgery. Diagnosis, Differential. Female. Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / surgery. Humans. Middle Aged

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17259702.001).
  • [ISSN] 1421-9700
  • [Journal-full-title] Audiology & neuro-otology
  • [ISO-abbreviation] Audiol. Neurootol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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78. Kim HY, Jung SN, Kwon H, Sohn WI, Moon SH: Angiomyoma in the buccal space. J Craniofac Surg; 2010 Sep;21(5):1634-5
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for angiomyoma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyoma is a rare benign tumor originated from vascular smooth muscle cells, in other words, the tunica media, and the characteristic is the detection of numerous blood vessels together with spindle-shape smooth muscle cells.
  • In the head and neck area, it is developed most frequently in the larynx and the turbinates, and in addition, the development in the oral cavity (lip, hard palate, tonsil), nose, ear, cheek, parotid gland, and submandibular region has been reported.
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20856064.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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79. Kuklani RM, Glavin FL, Bhattacharyya I: Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis: a case report. Head Neck Pathol; 2009 Dec;3(4):315-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor apparently arose from a cylindroma and had features of spiradenoma.
  • Cylindroma is an uncommon benign tumor, which originates from skin appendages and is most commonly found on the scalp and face with a strong predilection for middle-aged and elderly females.
  • Although cylindromas are usually benign neoplasms, carcinoma arising in such neoplasms is rare with only sporadic reports in literature.
  • The patient's main concern was painful lesions over her right ear that interfered with wearing of her glasses.

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  • [Cites] Br J Dermatol. 2001 Oct;145(4):653-6 [11703297.001]
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  • (PMID = 20596852.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2811564
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80. Zhao YS, Pang D, Wang F, Xue YW, Gao DN, Li H, Li K, Wang BY, Wang D, Li HY: Nipple aspirate fluid collection, related factors and relationship between carcinoembryonic antigen in nipple aspirate fluid and breast diseases in women in Harbin, PRC. Cancer Epidemiol Biomarkers Prev; 2009 Mar;18(3):732-8
MedlinePlus Health Information. consumer health - Breast Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Multivariate logistic regression analysis results showed the following to be significantly associated with a greater ability to obtain nipple aspiration fluids: earlier age at menarche [odds ratio (OR), 2.61; 95% confidence interval (95% CI), 1.15-5.91], lactating>12 months (OR, 2.28; 95% CI, 1.44-3.60), wet-type ear wax (OR, 3.80; 95% CI, 2.39-6.02), and fatty diet (OR, 1.56; 95% CI, 1.02-2.39).
  • CEA levels in nipple aspiration fluids of cancerous breasts were significantly higher than those from breasts with benign disease and healthy controls (ORadj, 5.39; P<0.01).
  • [MeSH-major] Biomarkers, Tumor / analysis. Body Fluids / chemistry. Breast Diseases / diagnosis. Carcinoembryonic Antigen / analysis. Nipples
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Chi-Square Distribution. China / epidemiology. Cross-Sectional Studies. Female. Humans. Logistic Models. Middle Aged. ROC Curve

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  • (PMID = 19273481.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen
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81. Jakobiec FA, Colby K, Bajart AM, Saragas SJ, Moulin A: Immunohistochemical studies of atypical conjunctival melanocytic nevi. Arch Ophthalmol; 2009 Aug;127(8):970-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ki-67 was the most valuable immunohistochemical adjunct to morphology for the diagnosis of these benign variant conjunctival nevi, because melanomas display a much higher proliferation index (>10% nuclear positivity among all cells counted) than the current nevi (approximately 1%).
  • [MeSH-major] Biomarkers, Tumor / metabolism. Conjunctival Neoplasms / metabolism. Neoplasm Proteins / metabolism. Nevus, Blue / metabolism. Nevus, Pigmented / metabolism
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, Neoplasm / metabolism. Female. Humans. Immunoenzyme Techniques. Ki-67 Antigen / metabolism. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Muramidase / metabolism. Retrospective Studies. S100 Proteins / metabolism. Young Adult

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  • (PMID = 19667333.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.2.1.17 / Muramidase
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82. Zhou L, Chen X, Huang W, Li K, Zhang X, Wang W: [Surgical management of minor salivary gland tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Nov;21(21):963-5
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: Retrospective analysis of 54 cases with minor salivary gland tumor operated in our hospital from 1997 to 2004.
  • Among the remaining 38 patients, 2 patients with nasal cavity adenoid cystic carcinoma died of tumor recurrence 2 and 3 years after the surgery respectively, one patient with laryngeal myoepithelial carcinoma died of tumor recurrence 3 years after the surgery and one patient with paranasal sinus mucoepidermoid carcinoma died of recurrence 17 months after the surgery.
  • Two patients with paranasal sinus adenoid cystic carcinoma recurred after the primary surgery and were survived without tumor after salvage surgery.
  • The other patients survived with no tumor recurrence.
  • The treatment policy for benign tumors is simple tumor excision, while that for malignant tumors is surgery combined with pre- or post-operative radiation therapy.
  • Complete surgical resection of tumor masses and tumor free margin is essential for successful treatment of malignant minor salivary gland tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18309648.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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83. Yeh SY, Chao TK: Leiomyoma of the external auditory canal--a case report and brief review of the literature. Eur Arch Otorhinolaryngol; 2005 May;262(5):397-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyoma of the external auditory canal--a case report and brief review of the literature.
  • It is extremely rare that leiomyoma appears in the external auditory canal.
  • A 47-year-old male with left external auditory canal leiomyoma presented with conductive hearing impairment and post-auricular swelling.
  • Tumor excision was successful via a retroauricular approach.
  • To date, including our case, only three cases of external auditory canal leiomyoma have been reported.
  • The tumor occurs mainly in adult males aged around 50 and should be included in the differential diagnoses for external auditory canal tumor.
  • In case of an external auditory canal tumor, even if it is believed to be benign before surgery, precise pathologic examination is required to exclude the possibility of malignancy.
  • [MeSH-major] Ear Canal / surgery. Ear Neoplasms / diagnosis. Ear Neoplasms / surgery. Leiomyoma / diagnosis. Leiomyoma / surgery
  • [MeSH-minor] Audiometry, Pure-Tone. Diagnosis, Differential. Hearing Loss, Conductive / etiology. Humans. Immunohistochemistry. Male. Middle Aged. Otologic Surgical Procedures. Otoscopy. Tomography, X-Ray Computed. Treatment Outcome

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  • [Cites] Acta Pathol Jpn. 1979 May;29(3):389-408 [222115.001]
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  • (PMID = 15368068.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 8
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84. Borowska K, Pietniczka-Załeska M, Sołtys J, Budzynowska K: [Adenoma polymorphum localised out of salivary glands in material of ENT Department MSS Hospital between 2007-2009 - two cases]. Otolaryngol Pol; 2009 Sep;63(7):80-2
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The adenoma polymorphum is benign salivary glands tumor.
  • The authors described two cases of tumor mixtus localised on soft palate and in external ear canal.
  • On examination there was a firm, circumscribed tumor of the palate in the right side.
  • Another case is 18-year old girl with progressive worsening of hearing .On examination external ear canal was blocked due to firm and round tumor on his upper wall.
  • The tumor was excised In local anesthesia.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Palatal Neoplasms / diagnosis. Palatal Neoplasms / surgery. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Oral Surgical Procedures / methods. Poland. Treatment Outcome. Young Adult

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  • (PMID = 20564907.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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85. Han Z, Lin GJ, Chi FL, Wang SY, Huang JM, Liu HJ, Zhang LR: The relationship between the extracellular matrix and the angiogenesis and metastasis of laryngeal carcinoma. ORL J Otorhinolaryngol Relat Spec; 2008;70(6):352-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Thirty-three cases of benign and malignant laryngeal tumors were included.
  • RESULTS: The expression of ECM1 (p = 0.004) and HA (p = 0.036) was significantly different between benign and malignant tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / secondary. Extracellular Matrix Proteins / metabolism. Laryngeal Neoplasms / pathology. Neovascularization, Pathologic / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Metastasis. Neoplasm Staging. Probability. Prognosis. Risk Assessment. Sampling Studies. Sensitivity and Specificity. Statistics, Nonparametric. Survival Analysis

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18984970.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ECM1 protein, human; 0 / Extracellular Matrix Proteins
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