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1. Barry P, Chan KG, Hsu J, Quek ML: Adenomatoid tumor of the tunica albuginea. Int J Urol; 2005 May;12(5):516-8
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  • [Title] Adenomatoid tumor of the tunica albuginea.
  • Adenomatoid tumors are benign mesothelial tumors most commonly found in the paratesticular structures, especially the epididymis.
  • Herein, we report a case of adenomatoid tumor originating in the tunica albuginea and mimicking an intratesticular neoplasm.
  • We review the ultrasonographic presentation and literature regarding adenomatoid tumors originating in the tunica albuginea and testicular parenchyma.
  • [MeSH-major] Adenomatoid Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 15948758.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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2. Mourali M, Kedous Z, El Fekih C, Ben Haj Hassine A, Ayadi A, Zineb NB: [Unexpected diagnosis of a cystic pelvic mass: benign mesothelioma of the uterus: case report]. Tunis Med; 2010 Aug;88(8):605-9
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  • [Title] [Unexpected diagnosis of a cystic pelvic mass: benign mesothelioma of the uterus: case report].
  • [Transliterated title] Diagnostic Inattendu devant une masse kystique pelvienne : mésotheliome bénin de l’utérus. A propos d’un cas.
  • BACKGROUND: Benign mesothelioma is a rare tumour mostly found in the genital tract.
  • Histologic exam and immnunochemistry concluded to a benign cystic mesothelioma.
  • CONCLUSION: The benign mesothelioma of the uterus is usually discovered in histology, differential diagnosis for solid forms can be made with leiomyoma or adenomyoma, whereas the cystic forms can be discussed essentially with the ovarian cysts.
  • The presence of mesothelial immunophenotype in immunochemistry improves diagnosis.
  • [MeSH-major] Mesothelioma, Cystic. Uterine Neoplasms

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  • (PMID = 20711970.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Tunisia
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3. Bansal A, Zakhour HD: Benign mesothelioma of the appendix: an incidental finding in a case of sigmoid diverticular disease. J Clin Pathol; 2006 Jan;59(1):108-10
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  • [Title] Benign mesothelioma of the appendix: an incidental finding in a case of sigmoid diverticular disease.
  • Benign multicystic mesothelioma is a well recognised but rare entity.
  • The aim of this report is to describe a case of a small mesothelial proliferation of the peritoneum.
  • An operation was performed for symptomatic sigmoid diverticular disease.
  • Microscopy revealed a benign mesothelioma.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Diverticulum / complications. Mesothelioma / diagnosis. Sigmoid Diseases / complications

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  • [Cites] Chir Ital. 2002 Jul-Aug;54(4):569-72 [12239771.001]
  • [Cites] Am J Surg Pathol. 1986 Dec;10(12):844-54 [3789251.001]
  • [Cites] Am J Surg Pathol. 1990 Apr;14(4):375-8 [2181883.001]
  • [Cites] J Korean Med Sci. 1989 Jun;4(2):111-5 [2597362.001]
  • [Cites] G Ital Oncol. 1989 Jan-Mar;9(1):39-42 [2707838.001]
  • (PMID = 16394291.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1860251
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4. Białas M, Szczepański W, Szpor J, Okoń K, Kostecka-Matyja M, Hubalewska-Dydejczyk A, Tomaszewska R: Adenomatoid tumour of the adrenal gland: a case report and literature review. Pol J Pathol; 2010;61(2):97-102
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  • [Title] Adenomatoid tumour of the adrenal gland: a case report and literature review.
  • Adenomatoid tumour (AT) is a rare, benign neoplasm of mesothelial origin, which usually occurs in the genital tract of both sexes.
  • Occasionally these tumours are found in extra genital locations such as heart, pancreas, skin, pleura, omentum, lymph nodes, retroperitoneum, intestinal mesentery and adrenal gland.
  • The most important thing about these tumours is not to mis-diagnose them as primary malignant or metastatic neoplasms.
  • The tumour was an incidental finding during abdominal CT-scan for an unrelated condition.
  • [MeSH-major] Adenomatoid Tumor / pathology. Adrenal Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Asymptomatic Diseases. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Incidental Findings. Male. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 20924994.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Hanley KZ, Facik MS, Bourne PA, Yang Q, Spaulding BO, Bonfiglio TA, Xu H: Utility of anti-L523S antibody in the diagnosis of benign and malignant serous effusions. Cancer; 2008 Feb 25;114(1):49-56
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  • [Title] Utility of anti-L523S antibody in the diagnosis of benign and malignant serous effusions.
  • BACKGROUND: Immunohistochemistry is helpful in distinguishing metastatic carcinoma from atypical mesothelial cells; however, it is not useful in differentiating atypical mesothelial cells from malignant mesothelial cells.
  • Using a mouse monoclonal antibody (L523S) against KOC, KOC expression was investigated in malignant tumors and reactive mesothelial cells in serous effusions.
  • METHODS: Seventy-six cases with paraffin-embedded pleural, pericardial, and peritoneal serous effusion cell blocks including 60 malignant serous effusions (11 malignant pleural mesotheliomas and 49 metastatic carcinomas) and benign pleural effusions (14 cases with reactive mesothelial cells and 2 cases with atypical cells with uncertain significance) were selected for immunohistochemical analysis with L523S, calretinin, and CK5/6.
  • RESULTS: Immunohistochemical studies showed that positive staining for KOC of variable degrees of intensity was observed in 47 of 60 cases in malignant serous effusions including 10 of 11 mesotheliomas and 36 of 49 metastatic carcinomas.
  • The associated reactive mesothelial cells were negative for KOC but positive for calretinin and CK5/6.
  • All 11 malignant mesotheliomas exhibited positivity for calretinin, and 9 of 11 cases had CK5/6 staining.
  • In addition, 16 cases that were originally diagnosed either as pleural effusions with reactive mesothelial cells (14) or atypical cells with uncertain significance (2) were also tested for KOC expression.
  • Interestingly, 3 of 16 cases exhibited various degrees of positivity for KOC, 2 of which were diagnosed as lung adenocarcinoma with a recurrence after tumor resection and 1 as malignant pleural mesothelioma.
  • CONCLUSIONS: Anti-L523S antibody is a useful marker for the detection of malignant cells in serous effusions and it can have significant utility in differentiating reactive mesothelial cells from malignant mesothelioma and metastatic carcinoma in combination with calretinin and CK5/6 staining.
  • [MeSH-major] Biomarkers, Tumor / analysis. Mesothelioma / diagnosis. Neoplasm Proteins / analysis. Pleural Effusion / diagnosis. Pleural Effusion, Malignant / diagnosis. RNA-Binding Proteins / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ascitic Fluid / chemistry. Calbindin 2. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Metastasis. Pericardial Effusion / chemistry. S100 Calcium Binding Protein G / analysis

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  • [Copyright] (c) 2007 American Cancer Society
  • (PMID = 18098206.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calb2 protein, mouse; 0 / Calbindin 2; 0 / IMP3 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Proteins; 0 / S100 Calcium Binding Protein G
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6. Bestard Vallejo JE, Tremps Velázquez E, Blázquez Mañá C, Celma Doménech A, de Torres Ramírez I, Morote Robles J: [Adenomatoid tumour of epididymis: the most common tumour of the paratesticular structures]. Actas Urol Esp; 2008 Jun;32(6):611-7

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  • [Title] [Adenomatoid tumour of epididymis: the most common tumour of the paratesticular structures].
  • [Transliterated title] Tumor adenomatoide de epididimo: el tumor más frecuente de las estructuras paratesticulares.
  • INTRODUCTION: Paratesticular tumours are rare but generally benign neoplasms, usually treated by local excission.
  • Adenomatoid tumours of epididymis are the most common of these tumours.
  • OBJECTIVES: Analyze paratesticular tumours treated in our center and describe dyagnosis and treatment of adenomatoid tumours of epididymis.
  • MATERIAL AND METHODS: We retrospectively review 8 patients with paratesticular tumours treated from July 1997 to July 2007.
  • RESULTS: Patients median age was 44.1 years (22-69), presenting most of them subacute scrotal tumour with median size by ultrasound of 2.8 cm (1.5-7).
  • All of them were locally extirpated except one with suspicion of a malignant polyorchidism and another one with an apparently intratesticular lesion of great size.
  • Dyagnosis was in 4 cases adenomatoid tumour of epididymis, in two cases fibrous pseudotumour of epididymis, in one case leiomyoma of epididymis and in one case angiolipoma of spermatic cord.
  • Just in one case diagnosed of adenomatoid tumour of epididymis ultrasound confirmed solid tumour suggesting the final dyagnosis.
  • CONCLUSIONS: Adenomatoid tumors of epididymis are rare tumours which may present at any age.
  • Benignity of adenomatoid tumour of epididymis as well as most of the other paratesticular tumours should make local excission the treatment of choice and, when any doubt existed, peroperatory biopsy should be performed.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 18655344.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 19
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7. Pila Pérez R, Rosales Torres P, Pila Peláez R, Holguín Prieto V, Torres Vargas E: [Adenomatoid tumor of the epididymis: an infrequent case]. Arch Esp Urol; 2009 Oct;62(8):656-60

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  • [Title] [Adenomatoid tumor of the epididymis: an infrequent case].
  • [Transliterated title] Tumor adenomatoide del epidídimo: una infrecuente observación.
  • OBJECTIVES: To present a new case of adenomatoid tumor of the epididymis, the first report in our hospital since 1962.
  • METHODS: We report a clinical case with a brief bibliographic review about adenomatoid tumor of the epididymis.
  • Physical examination and ultrasound study demonstrated a tumor of 5x5x2 cm.
  • It was removed and the histopathological study was compatible with adenomatoid tumor of the epididymis.
  • CONCLUSION: The adenomatoid tumor of the epididymis is a neoplasm located in the paratesticular region, however it can be found infrequently in other sites.
  • Mesothelial origin has been mentioned and inflammation has played some role in the development of these tumors.
  • It can minimally invade adjacent structures, though it is benign without metastatic potential.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 19893140.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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8. Leaha C, Opris I, Macé P, Resch B, Sabourin JC: [Cystic adenomatoid tumor of the uterus]. Ann Pathol; 2009 Apr;29(2):134-7
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  • [Title] [Cystic adenomatoid tumor of the uterus].
  • [Transliterated title] Tumeur adénomatoïde kystique utérine.
  • Adenomatoid tumors are benign neoplasms of mesothelial origin, which involve the feminine and masculine genital tracts.
  • Our study presents an adenomatoid tumour, of cystic shape, which enables discussion of the histogenesis of this tumour and enlightenment of differential diagnoses which can at times result in an incorrect malignant diagnosis.
  • [MeSH-major] Adenomatoid Tumor / pathology. Uterine Neoplasms / pathology

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  • (PMID = 19364588.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G
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9. Rappa F, Ternullo MP: [Adenomatoid tumor]. Pathologica; 2006 Apr;98(2):164-6
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  • [Title] [Adenomatoid tumor].
  • [Transliterated title] Tumore adenomatoide.
  • Adenomatoid tumour is a neoplastic process of discussed origin, but the immunohistochemical phenotype leads a mesothelial derivation.
  • In the present report we described a case of Adenomatoid tumour of the uterus body in a 46 years old patient.
  • [MeSH-major] Adenomatoid Tumor / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Calbindin 2. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Keratins / analysis. Leiomyoma / diagnosis. Middle Aged. Neoplasm Proteins / analysis. S100 Calcium Binding Protein G / analysis. Staining and Labeling

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  • (PMID = 16929792.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Actins; 0 / Calbindin 2; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 68238-35-7 / Keratins
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10. Cagle PT, Churg A: Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies. Arch Pathol Lab Med; 2005 Nov;129(11):1421-7
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  • [Title] Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies.
  • CONTEXT: Although much of the pathology literature focuses on differential diagnosis of diffuse malignant mesothelioma from other types of cancer, the primary diagnostic challenge facing the pathologist is often whether a mesothelial proliferation on a pleural biopsy represents a malignancy or a benign reactive hyperplasia.
  • DESIGN: Based on previous medical publications, extensive personal consultations, and experience on the United States-Canadian Mesothelioma Reference Panel and the International Mesothelioma Panel, salient information was determined about interpretation of benign versus malignant mesothelial proliferations on pleural biopsies.
  • RESULTS: Differentiation of benign reactive mesothelial hyperplasia from diffuse malignant mesothelioma is often difficult.
  • Benign reactive mesothelial hyperplasia may mimic many features ordinarily associated with malignancy, and diffuse malignant mesothelioma may be cytologically bland.
  • Entrapment of benign reactive mesothelial cells within organizing pleuritis may mimic tissue invasion.
  • CONCLUSIONS: Various histologic clues favor a benign over a malignant mesothelial proliferation and vice versa.
  • Invasion is the most reliable criterion for determining that a mesothelial proliferation is malignant.
  • When there is any doubt that a pleural biopsy represents a malignancy, we recommend a diagnosis of atypical mesothelial proliferation.
  • [MeSH-major] Epithelium / pathology. Mesothelioma / pathology. Pleura / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Hyperplasia / pathology. Neoplasm Invasiveness

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  • (PMID = 16253023.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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11. Bandier PC, Hansen A, Thorelius L: [Adenomatoid tumour of the adrenal gland]. Ugeskr Laeger; 2009 Jan 26;171(5):306-8
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  • [Title] [Adenomatoid tumour of the adrenal gland].
  • [Transliterated title] Adenomatoid tumor i binyre.
  • An adenomatoid tumour in the right suprarenal gland was discovered during clinical cancer staging of a 73-year-old woman.
  • Adenomatoid tumours in the suprarenal glands are rare and are most often found incidentally.
  • Differential diagnoses comprise malignant vascular neoplasm or adenocarcinoma.
  • Immunohistochemistry or electron microscopy allows uncomplicated distinction between these tumours.
  • [MeSH-major] Adenomatoid Tumor / pathology. Adrenal Gland Neoplasms / pathology

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  • [CommentIn] Ugeskr Laeger. 2009 Mar 16;171(12):1015; author reply 1015 [19306484.001]
  • (PMID = 19176156.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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12. Takeda M, Kasai T, Enomoto Y, Takano M, Morita K, Kadota E, Nonomura A: 9p21 deletion in the diagnosis of malignant mesothelioma, using fluorescence in situ hybridization analysis. Pathol Int; 2010 May;60(5):395-9
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  • [Title] 9p21 deletion in the diagnosis of malignant mesothelioma, using fluorescence in situ hybridization analysis.
  • Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as one of the most common genetic alterations in malignant mesotheliomas (MMs).
  • Previous studies showed that this alteration might be useful for differentiating benign from malignant mesothelial tumors in cytology and surgical specimens.
  • The purpose of this study is to evaluate the diagnostic utility of 9p21 homozygous deletion assessed by FISH in mesothelial neoplasm and hyperplasia of Japanese patients using paraffin-embedded tissue.
  • In contrast, no cases of adenomatoid tumor, benign mesothelial multicystic tumor, reactive mesothelial hyperplasia or pleuritis showed 9p21 deletion (P < 0.005).
  • 9p21 homozygous deletion correlated well with p16 protein expression in the tumor cells.
  • Our study suggests that 9p21 homozygous deletion assessed by FISH on paraffin-embedded tissue may be very useful for differentiating MM from reactive mesothelial proliferation.
  • [MeSH-major] Chromosomes, Human, Pair 9. Genes, p16. Heart Neoplasms / diagnosis. In Situ Hybridization, Fluorescence / methods. Mesothelioma / diagnosis. Peritoneal Neoplasms / diagnosis. Pleural Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. DNA, Neoplasm / analysis. Epithelium / pathology. Female. Gene Deletion. Gene Dosage. Humans. Pericardium / metabolism. Pericardium / pathology

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  • (PMID = 20518890.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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13. Alvarez Maestro M, Tur Gonzalez R, Alonso Dorrego JM, Jesus De la Peña Barthel J, Nistal Martin De Serrano M: [Adenomatoid tumors of the epididymis and testicle: report of 9 cases and bibliographic review]. Arch Esp Urol; 2009 Mar;62(2):137-41
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  • [Title] [Adenomatoid tumors of the epididymis and testicle: report of 9 cases and bibliographic review].
  • [Transliterated title] Tumor adenomatoide de epidídimo intratesticular: A proposito de nueve casos y revisión de la literatura.
  • BACKGROUND: To report the cases of adenomatoid tumors seen at Hospital Universitario La Paz in the last 15 years.
  • METHODS: A clinical, pathological, and surgical study was conducted of males with testicular or paratesticular tumors with a histological report of adenomatoid tumor.
  • RESULTS: Among the nine cases studied, seven had paratesticular and two intratesticular adenomatoid tumors.
  • Treatment of choice was mass removal for epididymal tumors and orchidectomy for intratesticular tumors.
  • CONCLUSIONS: Adenomatoid tumors are uncommon benign neoplasms of a possible mesothelial origin.
  • Because of their benign nature, the treatment of choice is local excision (conservative surgery), but orchidectomy was performed in two cases due to tumor location.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male. Testicular Neoplasms

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  • (PMID = 19448282.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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14. Szczepulska-Wójcik E, Langfort R, Roszkowski-Sliz K: [A comparative evaluation of immunohistochemical markers for the differential diagnosis between malignant mesothelioma, non-small cell carcinoma involving the pleura, and benign reactive mesothelial cell proliferation]. Pneumonol Alergol Pol; 2007;75(1):57-69
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  • [Title] [A comparative evaluation of immunohistochemical markers for the differential diagnosis between malignant mesothelioma, non-small cell carcinoma involving the pleura, and benign reactive mesothelial cell proliferation].
  • INTRODUCTION: Histopathological diagnosis of malignant mesothelioma (MM) and differentiating it from tumors infiltrating the pleura is very difficult.
  • Distinguishing benign reactive mesothelial cell proliferation from MM also presents problems.
  • The objective of this study was to evaluate the significance of selected immunohistochemical stains in differentiating MM from non-small cell lung cancers infiltrating the pleura and from benign reactive mesothelial cell proliferation.
  • MATERIAL AND METHODS: The material encompassed 86 cases of MM, 54 cases of NSCLC infiltrating the pleura, and 43 cases of benign reactive mesothelial cell proliferation.
  • It included broad-spectrum antibodies to cytokeratins (CKAE1/AE3, CKMNF116), vimentin, epithelial membrane antigen (EMA), mesothelial cells (HBME1, CK5/6, calretinin), adenocarcinoma cells (BerEp4, B72.3, CEA, TTF1), antibodies enabling the assessment of proliferation (Mib1) and cell-cycle regulating proteins (p53).
  • Benign reactive mesothelial cell proliferation: Protein p53 was present in 9.3% of cases, whereas no positive staining for EMA was found.
  • CONCLUSION: In diagnosing mesothelioma it is necessary to use a panel of immunohistochemical stains, which should contain antibodies to markers for adenocarcinoma and mesothelioma.
  • In the diagnosis of spindle-cell pleural tumors and the fibrous form of MM and benign reactive mesothelial cell proliferation , markers of mesothelial cells are noncontributory.
  • [MeSH-major] Antigens, Tumor-Associated, Carbohydrate / analysis. Biomarkers, Tumor / analysis. Carcinoma, Non-Small-Cell Lung / pathology. Mesothelioma / pathology. Neoplasm Proteins / analysis. Neoplasms, Mesothelial / pathology. Pleural Neoplasms / pathology

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  • (PMID = 17541913.001).
  • [ISSN] 0867-7077
  • [Journal-full-title] Pneumonologia i alergologia polska
  • [ISO-abbreviation] Pneumonol Alergol Pol
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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15. Kaur J, Dey P: Micronucleus to distinguish adenocarcinoma from reactive mesothelial cell in effusion fluid. Diagn Cytopathol; 2010 Mar;38(3):177-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Micronucleus to distinguish adenocarcinoma from reactive mesothelial cell in effusion fluid.
  • To evaluate the role of the scoring of micronucleated cell (MNC) to distinguish reactive mesothelial cells from adenocarcinoma cells in effusion fluid.
  • A total of 20 cases of unequivocal metastatic adenocarcinoma and 15 controls with reactive mesothelial cell proliferation in ascetic fluid were selected for scoring of the MNC.
  • The mean number of MNC in metastatic adenocarcinoma and reactive mesothelial cells were 21 + 6.53 and 2.93 + 2.63, respectively, per 1000 cells.
  • The scoring of MNC can be used as an additional biomarker and to discriminate between benign reactive mesothelial cells versus metastatic adenocarcinoma in effusion fluids in difficult situation.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ascites / diagnosis. Micronuclei, Chromosome-Defective. Neoplasms, Mesothelial / diagnosis
  • [MeSH-minor] Adult. Aged. Cell Proliferation. Diagnosis, Differential. Epithelium / pathology. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / diagnosis

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  • (PMID = 19693939.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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16. Lin CY, Tsai FC, Fang BR: Mesothelial/monocytic incidental cardiac excrescences of the heart: case report and literature review. Int J Clin Pract Suppl; 2005 Apr;(147):23-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesothelial/monocytic incidental cardiac excrescences of the heart: case report and literature review.
  • Mesothelial/monocytic incidental cardiac excrescences (MICE) of the heart are rare benign entities that have only been diagnosed incidentally, following cardiac surgical procedure.
  • On microscopic examination, the findings initially were confused with true neoplasm.

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  • (PMID = 15875613.001).
  • [ISSN] 1368-504X
  • [Journal-full-title] International journal of clinical practice. Supplement
  • [ISO-abbreviation] Int J Clin Pract Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 13
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17. Llarena Ibarguren R, Rodríguez JG, Olano Grasa I, Azurmendi Arín I, Cantón Aller E, Pertusa Peña C: [Adenomatoid tumor of the epididymis. Report of five cases]. Arch Esp Urol; 2008 Sep;61(7):831-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the epididymis. Report of five cases].
  • [Transliterated title] Tumor adenomatoide epididimario. Aportación de 5 casos.
  • OBJECTIVE: Adenomatoid tumor of the epididymis is unfrequent, benign, with no malignant outcomes described.
  • METHODS: We report five cases, with patient's ages varying from 31 to 76 years, and tumor sizes from 6 to 30 mm.
  • Pathology confirmed the benign adenomatoid character in all cases.
  • CONCLUSIONS: Despite the clinical, ultrasound and physical examination findings suggest the localization in the epididymis and its benign character, surgical exploration is mandatory with surgical excision of the paratesticular mass.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 18972922.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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18. Moyano Calvo JL, Giraldez Puig J, Sánchez de la Vega J, Dávalos Casanova G, Morales López A: [Adenomatoid tumor of the epididymis]. Actas Urol Esp; 2007 Apr;31(4):417-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the epididymis].
  • [Transliterated title] Tumor adenomatoide de epididimo.
  • OBJECTIVE: Paratesticular tumors are very rare and mostly bening.
  • Wa aport a new case of adenomatoid tumor of epididymis METHOD: Male of 40 years old with solid lesion in epidididymis tale treated with mass exéresis RESULTS: Adenoamotid tumor of the epididymis confirmed with hystopathologic technique CONCLUSION: Adenomatoid tumor of epididymis is the most frequent paratesticular tumors and when is suspected, conservative surgery must be performed.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 17633930.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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19. González Resina R, Carranza Carranza A, Congregado Córdoba J, Conde Sánchez JM, Congregado Ruiz CB, Medina López R: [Paratesticular adenomatoid tumor: a report of nine cases]. Actas Urol Esp; 2010 Jan;34(1):95-100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Paratesticular adenomatoid tumor: a report of nine cases].
  • [Transliterated title] Tumor adenomatoide paratesticular: una serie de nueve casos.
  • INTRODUCTION: Paratesticular tumors are rare.
  • Most of them are benign, and adenomatoid tumors are most common.
  • These tumors sometimes infiltrate the testicular parenchyma and require differential diagnosis with malignant tumors.
  • MATERIALS AND METHODS: A retrospective study of nine patients with paratesticular adenomatoid tumors seen during a nine-year period (2000-2008) is reported.
  • The tumor most commonly occurred as a small, usually oval, nodule in the tail of epididymis.
  • Our series included a case each of intraparenchymal tumor of the testis and tumor of the tunica vaginalis.
  • [MeSH-major] Adenomatoid Tumor / pathology. Epididymis / pathology. Genital Neoplasms, Male / pathology
  • [MeSH-minor] Adult. Calbindin 2. Diagnosis, Differential. Humans. Keratins / analysis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Retrospective Studies. S100 Calcium Binding Protein G / analysis. Testis / pathology

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  • (PMID = 20223139.001).
  • [ISSN] 1699-7980
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Calbindin 2; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 68238-35-7 / Keratins
  • [Number-of-references] 13
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20. Asghar S, Qureshi N, Awan A: Benign mesothelioma of peritoneum presenting as a pelvic mass. J Coll Physicians Surg Pak; 2008 Nov;18(11):723-5
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  • [Title] Benign mesothelioma of peritoneum presenting as a pelvic mass.
  • A large solitary multiloculated pelvic cyst in a 40-year-old woman with chronic pelvic pain was diagnosed to be a Multicystic Benign Mesothelioma (MBM) of peritoneum at laparotomy.
  • [MeSH-major] Mesothelioma, Cystic / diagnosis. Ovarian Neoplasms / diagnosis. Pelvic Neoplasms / diagnosis. Pelvic Pain / diagnosis. Peritoneal Neoplasms / diagnosis

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  • (PMID = 18983801.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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21. Garrido Abad P, Jiménez Gálvez M, Herranz Fernández LM, Bocardo Fajardo G, Arellano Gañán R, Pereira Sanz I: [Adenomatoid tumor of the epididymis. Report of two cases]. Arch Esp Urol; 2007 Jul-Aug;60(6):700-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the epididymis. Report of two cases].
  • [Transliterated title] Tumor adenomatoide de epidídimo. Aportación de dos casos.
  • OBJECTIVE: Tumors of the epididymis are rare.
  • They are unusually benign and adenomatoid tumors are the most frequent.
  • Report of two cases of this kind of tumor of the epididymis.
  • METHODS/RESULTS: We report two cases of adenomatoid tumor of the epididymis diagnosed at our hospital during last year.
  • Pathological diagnosis was adenomatoid tumor.
  • CONCLUSIONS: The majority of epididymal tumors follow a benign course.
  • In the finding of an epididymal mass, after palpation and imaging tests, organ sparing surgery (epididymectomy) is recommended.
  • [MeSH-major] Adenomatoid Tumor. Epididymis. Genital Neoplasms, Male

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  • (PMID = 17847749.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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22. Kilic N, Tilki D, Ergün B, Seitz M, Stief CG, Reich O, Ergün S: Epithelial versus endothelial CEACAM1 expression and angiogenesis in epididymal adenomatoid tumor. Anticancer Res; 2010 Jul;30(7):2651-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial versus endothelial CEACAM1 expression and angiogenesis in epididymal adenomatoid tumor.
  • BACKGROUND/AIM: To study the expression of the pro-angiogenic factor carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in epididymal adeno-matoid tumor tissue, a very rare benign neoplasia, in relation to its vascularization.
  • MATERIALS AND METHODS: Immunohistochemistry for CEACAM1 and for both endothelial markers CD31 and CD34 was performed in normal human epididymal and epididymal adenomatoid tumor tissue.
  • The vessel density was calculated in four tumor regions with different degrees of vascularization in comparison to the vascularization of the normal epididymal tissue.
  • RESULTS: CEACAM1 was found in normal epididymal epithelium, while the epithelium of tumor glands was mostly negative.
  • Only few blood vessels and lymphatics in adenomatoid tumor tissue expressed CEACAM1.
  • The assessment of vascularization revealed either equal or a significantly lower vessel density in some adenomatoid tumor regions in comparison to normal epididymal tissue.
  • DISCUSSION: These data demonstrate that despite its epithelial down-regulation, CEACAM1 is not present in the majority of adenomatoid tumor blood vessels, which might be related to the lower angiogenic activity and benign behaviour of this tumor.
  • [MeSH-major] Adenomatoid Tumor / blood supply. Antigens, CD / biosynthesis. Cell Adhesion Molecules / biosynthesis. Testicular Neoplasms / blood supply
  • [MeSH-minor] Antigens, CD31 / biosynthesis. Antigens, CD34 / biosynthesis. Endothelial Cells / metabolism. Epididymis / blood supply. Epididymis / metabolism. Epithelial Cells / metabolism. Humans. Immunohistochemistry. Male. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology

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  • (PMID = 20682994.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / CD66 antigens; 0 / Cell Adhesion Molecules
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23. Lehsnau M, Hecht L: [Adenomatoid tumor of the testes--a rare entity. Clinical, diagnostic and therapeutic aspects]. Urologe A; 2006 Nov;45(11):1431-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the testes--a rare entity. Clinical, diagnostic and therapeutic aspects].
  • [Transliterated title] Adenomatoidtumor des Hodens--eine seltene Entität. Klinische, diagnostische und therapeutische Aspekte.
  • Adenomatoid tumor with intra-testicular localization is rare.
  • Adenomatoid tumors occur in both sexes and are also found in the uterus, ovary and fallopian tubes of the female genital tract.
  • Adenomatoid tumors are benign proliferations of mesothelial origin.
  • We report the case of a 50-year-old male with an adenomatoid tumor of the left testis.
  • [MeSH-major] Adenomatoid Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Calbindin 2. Diagnosis, Differential. Humans. Keratins / analysis. Male. Middle Aged. Orchiectomy. Prognosis. S100 Calcium Binding Protein G / analysis. Testis / pathology. Tomography, X-Ray Computed. Ultrasonography. Vimentin / analysis

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  • [Cites] Am J Surg Pathol. 2004 Jan;28(1):77-83 [14707867.001]
  • [Cites] Eur Urol. 1996;30(1):127-8 [8854081.001]
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  • (PMID = 16933122.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / Vimentin; 68238-35-7 / Keratins
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24. El-Daly H, Rao P, Palazzo F, Gudi M: A rare entity of an unusual site: adenomatoid tumour of the adrenal gland: a case report and review of the literature. Patholog Res Int; 2010;2010:702472
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare entity of an unusual site: adenomatoid tumour of the adrenal gland: a case report and review of the literature.
  • This is a case report of a 51 year old male who was found to have an incidental left sided non-functioning adrenal mass on routine medical examination and which was confirmed by CT and MRI scans.
  • On gross examination the tumour was a solitary well circumscribed solid-cystic mass with a homogenous pinkish white cut surface.
  • On microscopic examination, the tumour was composed of variably sized tubules and fenestrated channels lined by bland cuboidal cells to epithelioid cells.
  • Immunohistochemically the tumour cells stained with calretinin, Cam5.2, CK7, vimentin and focally with EMA.
  • A diagnosis of an adenomatoid tumour as made.
  • Adenomatoid tumours are rare benign tumours of mesothelial derivation.
  • The adrenal gland is devoid of a mesothelial lining and the most accepted hypothesis for an adenomatoid tumour originating in the adrenal gland is derivation from mesothelial rests.
  • As the adrenal gland is an extremely rare site of occurrence for an adenomatoid tumour, it is frequently mistaken for adrenocortical tumours or a pheochromocytoma clinically and radiologically.

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  • (PMID = 21151721.001).
  • [ISSN] 2042-003X
  • [Journal-full-title] Pathology research international
  • [ISO-abbreviation] Patholog Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2990199
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25. Bisceglia M, Carosi I, Scillitani A, Pasquinelli G: Cystic lymphangioma-like adenomatoid tumor of the adrenal gland: Case presentation and review of the literature. Adv Anat Pathol; 2009 Nov;16(6):424-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic lymphangioma-like adenomatoid tumor of the adrenal gland: Case presentation and review of the literature.
  • Adenomatoid tumors (AT) are usually found in the genital tract of both sexes.
  • Thirty-four cases have been reported so far, more often presenting grossly as solid tumors, rarely as solid with cystic areas, and 5 cases were almost entirely cystic.
  • On light microscopy the diagnosis may be very difficult if the tumor is rich in vacuolated cells, mimicking metastatic signet ring-cell adenocarcinoma.
  • Immunophenotyping and/or electron microscopy are paramount in helping to ascertain their mesothelial lineage.
  • Lymphangioma is the main histologic mimic of solid-cystic and cystic AT-AG, but lymphangioma is immunopositive for endothelial markers and negative for cytokeratins and mesothelial markers.
  • The adrenal tumor was 5.5 cm in size and was fully investigated immunohistochemically and ultrastructurally.
  • [MeSH-major] Adenomatoid Tumor / pathology. Adrenal Gland Neoplasms / pathology. Lymphangioma, Cystic / pathology

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  • (PMID = 19851133.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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26. Rizkalla HF, Higgins M, Kelehan P, O'Herlihy C: Pathological findings associated with the presence of a mirena intrauterine system at hysterectomy. Int J Gynecol Pathol; 2008 Jan;27(1):74-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological findings associated with the presence of a mirena intrauterine system at hysterectomy.
  • Thirty hysterectomy specimens contained benign leiomyomata with associated reduced reactivity in the uterine cavity and incomplete suppression of the endometrium.
  • In addition to leiomyomas, 1 specimen had an atypical polypoid adenomyoma and 1 had a benign adenomatoid tumor.


27. Hamamatsu A, Arai T, Iwamoto M, Kato T, Sawabe M: Adenomatoid tumor of the adrenal gland: case report with immunohistochemical study. Pathol Int; 2005 Oct;55(10):665-9
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  • [Title] Adenomatoid tumor of the adrenal gland: case report with immunohistochemical study.
  • Adrenal adenomatoid tumor (AT) is a recently recognized disease with marked male predominance.
  • Herein is presented a case of adrenal AT incidentally found in a 30-year-old man and results of immunohistochemical examination of the tumor.
  • Cut surface showed a relatively well-circumscribed firm tumor with a white solid appearance.
  • Histologically, the tumor had the typical appearance of AT described in the genital tract.
  • Immunohistochemically, the tumor cells were positive for calretinin, D2-40, WT1, mesothelial cell antigen, CA125, thrombomodulin, vimentin and cytokeratins (stained by AE1 + AE3, OV-TL 12/30, CAM5.2 and MNF116), and negative for endothelial markers (CD31, CD34 and factor VIII-related antigen) and CD56.
  • CD56-positive adrenocortical cells were diffusely scattered in the tumor, especially in its periphery.
  • These findings confirm mesothelial origin of the tumor and suggest that this tumor has little relation to sex hormone despite male predominance.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Coronary Thrombosis / mortality. Coronary Thrombosis / pathology. Fatal Outcome. Humans. Immunoenzyme Techniques. Male

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  • (PMID = 16185299.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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28. Yasumitsu A, Tabata C, Tabata R, Hirayama N, Murakami A, Yamada S, Terada T, Iida S, Tamura K, Fukuoka K, Kuribayashi K, Nakano T: Clinical significance of serum vascular endothelial growth factor in malignant pleural mesothelioma. J Thorac Oncol; 2010 Apr;5(4):479-83
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  • [Title] Clinical significance of serum vascular endothelial growth factor in malignant pleural mesothelioma.
  • INTRODUCTION: Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure.
  • METHODS: Serum concentrations of VEGF were measured in 51 patients with MPM and 42 individuals with benign asbestos-related diseases (asbestosis or pleural plaques) or who were healthy despite asbestos exposure.
  • [MeSH-major] Asbestosis / blood. Biomarkers, Tumor / blood. Mesothelioma / blood. Pleural Neoplasms / blood. Vascular Endothelial Growth Factor A / blood
  • [MeSH-minor] Aged. Asbestos / adverse effects. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Neoplasm Staging. Occupational Exposure. Prognosis. ROC Curve. Survival Rate

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  • [CommentIn] J Thorac Oncol. 2011 May;6(5):971-2 [21623273.001]
  • (PMID = 20357617.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 1332-21-4 / Asbestos
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29. Passman C, Urban D, Klemm K, Lockhart M, Kenney P, Kolettis P: Testicular lesions other than germ cell tumours: feasibility of testis-sparing surgery. BJU Int; 2009 Feb;103(4):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular lesions other than germ cell tumours: feasibility of testis-sparing surgery.
  • Patients with atrophy, germ cell tumours, infection or torsion were excluded.
  • The study comprised men who had radical orchidectomy for suspected germ-cell tumour but had other final pathology, and those where testis-sparing surgery was attempted for a presumed benign lesion.
  • The lesions could be categorized as inflammatory (three hyalinized fibrosis, two sarcoidosis, one chronic inflammation), cystic (one epidermoid cyst, one unilocular cyst), benign neoplasms (two adenomatoid tumours, one Leydig cell tumour, one capillary haemangioma) or malignant neoplasms (one lymphoma).
  • In the other five, testis-sparing surgery was not attempted because the preoperative impression was that of a germ cell tumour.
  • CONCLUSION: Testis-sparing surgery might be possible if there is significant suspicion of a benign lesion.
  • [MeSH-minor] Adolescent. Adult. Aged. Feasibility Studies. Humans. Leydig Cell Tumor / pathology. Leydig Cell Tumor / surgery. Leydig Cell Tumor / ultrasonography. Male. Middle Aged. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18793303.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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30. Jain M, Agarwal S, Mandal S: Variation in clinical and genitourinary lesions associated with pulmonary hypoplasia in Potter's syndrome--two autopsy reports. Indian J Pathol Microbiol; 2006 Jul;49(3):416-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present two autopsy cases which presented with abnormal facies, oligohydramnios, pulmonary hypoplasia and genitourinary abnormality.
  • One case presented with infantile polycystic kidney whereas in the other case both the kidneys were normal but had adenomatoid tumour of left testis.
  • In both the cases pulmonary hypoplasia was the cause of death rather than genitourinary abnormality.

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  • (PMID = 17001905.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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31. Ordóñez NG: Value of estrogen and progesterone receptor immunostaining in distinguishing between peritoneal mesotheliomas and serous carcinomas. Hum Pathol; 2005 Nov;36(11):1163-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of estrogen and progesterone receptor immunostaining in distinguishing between peritoneal mesotheliomas and serous carcinomas.
  • The differential diagnosis between peritoneal mesotheliomas and serous carcinomas involving the peritoneum may be difficult, but it can be facilitated by the use of immunohistochemistry.
  • To determine whether estrogen receptors (ER) or progesterone receptors (PR) may have any value as immunohistochemical markers for discriminating between these malignancies, 40 serous carcinomas of the ovary metastatic to the peritoneum, 7 primary peritoneal serous carcinomas, 30 epithelioid peritoneal malignant mesotheliomas, 5 well-differentiated papillary mesotheliomas, and 4 adenomatoid tumors were immunostained for ER and PR.
  • None of the mesotheliomas or adenomatoid tumors expressed ER or PR.
  • It is concluded that, because of its high sensitivity for serous carcinomas, ER immunostaining could be very useful in distinguishing between serous carcinomas and peritoneal mesotheliomas.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cystadenocarcinoma, Serous / diagnosis. Mesothelioma / diagnosis. Peritoneal Neoplasms / diagnosis. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • [CommentIn] Hum Pathol. 2005 Nov;36(11):1153 [16260266.001]
  • (PMID = 16260268.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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32. Yeh CJ, Chuang WY, Chou HH, Jung SM, Hsueh S: Multiple extragenital adenomatoid tumors in the mesocolon and omentum. APMIS; 2008 Nov;116(11):1016-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple extragenital adenomatoid tumors in the mesocolon and omentum.
  • Adenomatoid tumors are benign mesothelial neoplasms most commonly found in the male and female genital tracts.
  • Extragenital adenomatoid tumors are rare, most of them being solitary tumors.
  • To our knowledge, only one case of multiple extragenital adenomatoid tumors, involving the liver and peritoneum, has been reported to date.
  • Here we report another case of multiple extragenital adenomatoid tumors involving the mesocolon and omentum.
  • The patient was transferred to our hospital without resection due to the intraoperative finding of multiple peritoneal tumors.
  • At our hospital, an 8.0x7.5x6.0 cm tumor at the mesocolon of the sigmoid colon and three omental nodules measuring up to 2.5x2.0x1.7 cm were resected.
  • Immunohistochemically, the tumor cells were positive for pan-cytokeratin AE1/AE3, vimentin, cytokeratin 5/6 and calretinin.
  • Despite their rarity, adenomatoid tumors should be included in the differential diagnosis of multiple intra-abdominal tumors.
  • [MeSH-major] Adenomatoid Tumor / pathology. Mesocolon / pathology. Neoplasms, Multiple Primary / pathology. Omentum / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 19133002.001).
  • [ISSN] 1600-0463
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / Vimentin; 68238-35-7 / Keratins
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33. Canedo-Patzi AM, León-Bojorge B, de Ortíz-Hidalgo C: [Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases]. Gac Med Mex; 2006 Jan-Feb;142(1):59-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases].
  • [Transliterated title] Tumor adenomatoide del aparato genital, Estudio clinicopatológico e inmunohistoquímico de 9 casos.
  • OBJECTIVE: [corrected] Describe the histological andimmunohistochemicalfeatures of nine genital tract adenomatoid tumors.
  • MATERIAL AND METHODS: Nine cases of adenomatoid tumors were collected from the files of the Pathology department at a private hospital (ABC Hospital).
  • Tumors were studied from a histological and inmunohistochemical perspective.
  • Tumors were located in the uterus (seven),fallopian tube (one) and epididymis (one).
  • Tumor size ranged from 0.4 to 5.8 cm.
  • Arrangement of the neoplastic tubules around fascicles of smooth muscle; angiomatoidpattern with a peripheral location, and solid and adenoidpatterns with a central location in the tumor were some of the observed histological features.
  • Immunohistochemically all tumors exhibited strong and diffuse positivity for calretinin and AE1/AE3.
  • Thrombomodulin was positive in all tumors (focal and weak in angiomatoid pattern and diffuse and strong in adenoid and solid patterns).
  • The CK5/6 antibody was positive in seven tumors (diffuse in three and focal in four).
  • Two tumors were negative for this marker.
  • All tumors were negative for CD31.
  • CONCLUSIONS: The immunopheno type of the adenomatoid tumors in our series confirms their mesothelial origin.
  • [MeSH-major] Adenomatoid Tumor / pathology. Epididymis. Fallopian Tube Neoplasms / pathology. Genital Neoplasms, Male / pathology. Uterine Neoplasms / pathology

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  • (PMID = 16548294.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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34. Ghossain MA, Chucrallah A, Kanso H, Aoun NJ, Abboud J: Multilocular adenomatoid tumor of the ovary: ultrasonographic findings. J Clin Ultrasound; 2005 Jun;33(5):233-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multilocular adenomatoid tumor of the ovary: ultrasonographic findings.
  • We report the sonographic findings of a rare benign ovarian tumor in a 69-year-old woman.
  • Surgery revealed an adenomatoid tumor.
  • Adenomatoid tumors are benign lesions of mesothelial origin, usually solid in nature and rarely located in the ovaries. (c) 2005 Wiley Periodicals, Inc.
  • [MeSH-major] Adenomatoid Tumor / ultrasonography. Ovarian Neoplasms / ultrasonography

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc. J Clin Ultrasound 33:233-236, 2005.
  • (PMID = 16047378.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Manjunath GV, Nandini NM, Sunila: Fine needle aspiration cytology of adenomatoid tumour--a case report with review of literature. Indian J Pathol Microbiol; 2005 Oct;48(4):503-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology of adenomatoid tumour--a case report with review of literature.
  • Adenomatoid tumours are neoplasms of male and female genital tract with the epididymis being the most common site.
  • These benign tumours are asymptomatic or cause mild symptoms and a palpable mass.
  • Fine needle aspiration of these tumours is very useful to differentiate malignant from benign lesions and helps to avoid unnecessary aggressive surgical procedures.
  • FNAC of these benign epididymal tumours is diagnostic, rapid, reliable, conclusive and cost effective.
  • We are reporting a case of adenomatoid tumour of epididymis in a 41 year old male patient, diagnosed by FNAC and confirmed by histopathology.
  • [MeSH-major] Adenomatoid Tumor / pathology. Epididymis. Genital Neoplasms, Male / pathology

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  • (PMID = 16366111.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 7
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36. Sangoi AR, McKenney JK, Schwartz EJ, Rouse RV, Longacre TA: Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. Mod Pathol; 2009 Sep;22(9):1228-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases.
  • Adenomatoid tumors of the female and male genital tracts are well characterized as mesothelial in origin, but a detailed histological and immunohistochemical analysis comparing both traditional and newer mesothelial markers across gender and site has not been formally conducted.
  • A variety of morphologic features previously described as characteristic of adenomatoid tumors were evaluated in 44 adenomatoid tumors from the male and female genital tracts.
  • All (n=44) the adenomatoid tumors from both the female and male genital tracts demonstrated a distinctive thread-like bridging strand pattern.
  • Lymphoid aggregates were seen in all 12 adenomatoid tumors of male patients, but in only 4 of 32 (13%) tumors in female patients (P<0.0001).
  • The remaining morphologic features were variably present with no clear sex predilection.
  • Pankeratin, calretinin, and D2-40 reactivity were identified in all female (n=32) and male (n=12) genital tract adenomatoid tumors.
  • Adenomatoid tumors expressed WT-1 in 11/12 (92%) male patients and in 31/32 (97%) female patients.
  • In male patients, reactivity for CK5/6 and caldesmon was found in 1/12 (8%) and 0/12 (0%) adenomatoid tumors (respectively), whereas reactivity in female patients was found in 5/32 (16%) and 1/32 (3%); respectively.
  • Female tumors differ from their male counterparts by the frequent absence of lymphoid aggregates and the presence of a circumscribed margin when occurring in the fallopian tube.
  • Of the putative mesothelial markers evaluated, calretinin, D2-40, and WT-1 show a similar immunoprofile and have a higher sensitivity than CK5/6 and caldesmon in genital tract adenomatoid tumors.
  • [MeSH-major] Adenomatoid Tumor / pathology. Biomarkers, Tumor / analysis. Genital Neoplasms, Female / pathology. Genital Neoplasms, Male / pathology

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  • (PMID = 19543245.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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37. Vacharadze K, Burkadze G, Turashvili G, Kiria N: Argyrophilic nucleolar organizer regions in benign and malignant mesothelial lesions. Georgian Med News; 2005 Nov;(128):91-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Argyrophilic nucleolar organizer regions in benign and malignant mesothelial lesions.
  • The aim our study was to assess the usefulness of AgNOR stain in distinguishing between benign and malignant mesothelial lesions.
  • The patients were divided into three groups: group I -- reactive mesothelium (71 cases), group II -- hyperplastic mesothelium (66 cases), group III -- epithelial type mesothelioma (52 cases).
  • Our results show that AgNOR staining is useful to differentiate epithelial type mesothelioma and benign mesothelial lesions such as reactive and hyperplastic mesothelium.
  • AgNOR is highly sensitive, specific and cost-effective technology which can be used as an ancillary diagnostic approach for distinguishing between reactive and/or hyperplastic changes of mesothelium as well as in differential diagnosis of epithelial type mesothelioma.
  • [MeSH-major] Antigens, Nuclear / metabolism. Lung Diseases / metabolism. Lung Diseases / pathology. Neoplasms, Mesothelial / metabolism. Neoplasms, Mesothelial / pathology. Nuclear Proteins / metabolism

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  • (PMID = 16369075.001).
  • [ISSN] 1512-0112
  • [Journal-full-title] Georgian medical news
  • [ISO-abbreviation] Georgian Med News
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Georgia (Republic)
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / Nuclear Proteins; 0 / nucleolar organizer region associated proteins
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38. Füredi G, Szilágyi A, Bencsik Z, Altorjay A: [Adenomatoid tumor of the adrenal gland. Case report and review of the literature]. Orv Hetil; 2007 Aug 19;148(33):1563-5
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  • [Title] [Adenomatoid tumor of the adrenal gland. Case report and review of the literature].
  • [Transliterated title] A mellékvese adenomatoid tumora, avagy irodalmi barangolás egy igen ritka mesothelialis daganat nyomán.
  • Adenomatoid tumors of the adrenal gland are rather rare, asymptomatic neoplasias with benign behavior and usually are diagnosed incidentally.
  • The authors report a case of an adenomatoid tumor of the right adrenal gland in a 32-year-old man who sought evaluation because of fever and renal pain.
  • During investigation a tumor, localized in right adrenal gland, was identified by ultrasonography and CT.
  • The patient underwent adrenalectomy with histopathological and immunohistochemical diagnosis of adenomatoid tumor of the adrenal gland.
  • Based on literature data the epidemiology, symptoms, differential diagnosis, treatments, histopathology and prognosis of adenomatoid tumors of the adrenal gland are discussed.
  • [MeSH-major] Adenomatoid Tumor. Adrenal Gland Neoplasms
  • [MeSH-minor] Adrenalectomy. Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Fever / etiology. Humans. Immunohistochemistry. Male. Pain / etiology. Tomography, X-Ray Computed

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  • (PMID = 17686675.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 11
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39. Phillips V, McCluggage WG, Young RH: Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces. Int J Gynecol Pathol; 2007 Jan;26(1):16-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces.
  • We describe an unusual example of ovarian adenomatoid tumor that was an incidental finding in the ovary of a 52-year-old woman and was characterized by cells with abundant eosinophilic cytoplasm, an occasional feature of the adenomatoid tumor but one that, in an ovarian example, may cause added diagnostic confusion to that already engendered by the rarity of this neoplasm in the ovary.
  • The typical numerous small vacuoles of the neoplasm sometimes had the appearance of signet ring cells.
  • Tumor cells were positive with broad-spectrum cytokeratins as well as mesothelial markers CK5/6, WT1, and calretinin.
  • [MeSH-major] Adenomatoid Tumor / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 17197891.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Boldú J, Eguía VM: [Benign pleural diseases induced by asbestos]. An Sist Sanit Navar; 2005;28 Suppl 1:21-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign pleural diseases induced by asbestos].
  • Together with the prolonged latency existing between exposure and the disease, this means that for many years we will continue to see pleural clinical manifestations from past exposure, in spite of the increasingly limited use of asbestos in recent decades.
  • This exposure can show itself in different manifestations, both malign, such as mesothelioma, and benign, principally benign pleural effusion, pleural plaques, diffuse pleural fibrosis and massive atelectasis.

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  • (PMID = 15915168.001).
  • [ISSN] 1137-6627
  • [Journal-full-title] Anales del sistema sanitario de Navarra
  • [ISO-abbreviation] An Sist Sanit Navar
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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41. Pauser U, Kosmahl M, Sipos B, Klöppel G: [Mesenchymal tumors of the pancreas. Surprising, but not uncommon]. Pathologe; 2005 Feb;26(1):52-8
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  • [Title] [Mesenchymal tumors of the pancreas. Surprising, but not uncommon].
  • Mesenchymal tumors of the pancreas are rare.
  • They are resected because a solid or cystic pancreatic tumor is suspected.
  • Benign mesenchymal tumors comprise lymphangiomas, hemangiomas, schwannomas, solitary fibrous tumors, adenomatoid tumors, clear cell tumors, and hamartomas.
  • Malignant mesenchymal tumors include leiomyosarcomas, malignant peripheral nerve sheath tumors (MPNST), liposarcomas, malignant fibrous histiocytomas, Ewing's sarcomas, and primitive neuroectodermal tumors (PNET).
  • It is important to differentiate these tumors from anaplastic carcinomas and retroperitoneal tumors that infiltrate pancreatic tissue.

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  • (PMID = 15592845.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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42. Ikeda K, Tate G, Suzuki T, Kitamura T, Mitsuya T: IMP3/L523S, a novel immunocytochemical marker that distinguishes benign and malignant cells: the expression profiles of IMP3/L523S in effusion cytology. Hum Pathol; 2010 May;41(5):745-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IMP3/L523S, a novel immunocytochemical marker that distinguishes benign and malignant cells: the expression profiles of IMP3/L523S in effusion cytology.
  • Differentiating reactive mesothelial cells from metastatic carcinoma and malignant mesothelioma is critical in effusion cytology.
  • Numerous immunohistochemical/cytochemical reports use various antibodies in effusion samples, and most antibodies differentiate metastatic adenocarcinoma from malignant mesothelioma, but no antibodies help distinguish malignant mesothelioma from reactive mesothelial cells.
  • IMP3/L523S has been identified in several human malignant tumors.
  • A total of 229 cases of pleural and peritoneal effusion cytospecimens were evaluated for the study, including 39 benign effusions with reactive mesothelial cells and 190 metastatic malignant effusions.
  • IMP3 immunoreactivity was observed in 2 (5.1%) of 39 cases of reactive mesothelial cells, 138 (72.6%) of 190 cases of malignant effusion, 4 (36.4%) of 11 cases of malignant mesothelioma, 106 (75.7%) of 140 cases of metastatic adenocarcinoma, and 8 (100%) of 8 cases of squamous cell carcinoma.
  • In the peritoneal effusions, the sensitivity for the diagnosis of metastatic adenocarcinoma to distinguish reactive mesothelial cells was 92.3%.
  • However, the IMP3 antibody is a highly specific marker for malignant lesions, and thus, IMP3 staining is useful for distinguishing neoplastic cells from reactive mesothelial cells in effusion samples.
  • [MeSH-major] Adenocarcinoma / metabolism. Ascitic Fluid / metabolism. Biomarkers, Tumor / metabolism. Mesothelioma / metabolism. Neoplasm Proteins / metabolism. Pleural Effusion, Malignant / metabolism. RNA-Binding Proteins / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20060157.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / IMP3 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Proteins
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43. Nagata S, Aishima S, Fukuzawa K, Takagi H, Yonemasu H, Iwashita Y, Kinoshita T, Wakasugi K: Adenomatoid tumour of the liver. J Clin Pathol; 2008 Jun;61(6):777-80
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  • [Title] Adenomatoid tumour of the liver.
  • An unusual primary adenomatoid tumour arising in the normal liver is described.
  • Hepatectomy was performed, and the patient is alive and free of disease 1 year postsurgery.
  • Grossly, the tumour showed a haemorrhagic cut surface with numerous microcystic structures.
  • Immunohistochemical studies showed that the epithelioid cells were strongly positive for a broad spectrum of cytokeratins (AE1/AE3, CAM5.2, epithelial membrane antigen and cytokeratin 7) and mesothelial markers (calretinin, Wilms' tumour 1 and D2-40).
  • Atypically, abundant capillaries were observed; however, the cystic proliferation of epithelioid cells with vacuoles and immunohistochemical profile of the epithelioid element were consistent with hepatic adenomatoid tumour.
  • [MeSH-major] Adenomatoid Tumor / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Calbindin 2. Hepatectomy. Humans. Immunohistochemistry. Keratins / analysis. Male. Neovascularization, Pathologic. S100 Calcium Binding Protein G / analysis. Tomography, X-Ray Computed

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  • [Cites] Mod Pathol. 2003 Jun;16(6):613-7 [12808068.001]
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  • (PMID = 18505892.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2569191
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44. Shima M, Takahashi S, Maeda T, Masumori N, Itoh N, Tsukamoto T: [Adenomatoid tumor of the testis with testicular pain: a case report]. Hinyokika Kiyo; 2009 May;55(5):285-6
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  • [Title] [Adenomatoid tumor of the testis with testicular pain: a case report].
  • The intraoperative findings showed a small, white, elastic solid, a smooth surface tumor that originated from the tunica albuginea of the right testis.
  • It seemed to be benign macroscopically and partial orchiectomy was performed.
  • Pathohistological examination revealed an adenomatoid tumor of the testis which originated from the rete testis.
  • Adenomatoid tumor of the testis is a rare benign tumor.
  • Therefore, we should be aware that an adenomatoid tumor of the testis can be one of the differential diagnoses of acute scrotum.
  • [MeSH-major] Adenomatoid Tumor / complications. Adenomatoid Tumor / surgery. Pain / etiology. Scrotum. Testicular Neoplasms / complications. Testicular Neoplasms / surgery
  • [MeSH-minor] Acute Disease. Adult. Diagnosis, Differential. Humans. Male. Orchiectomy

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  • (PMID = 19507549.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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45. Timonera ER, Paiva ME, Lopes JM, Eloy C, van der Kwast T, Asa SL: Composite adenomatoid tumor and myelolipoma of adrenal gland: report of 2 cases. Arch Pathol Lab Med; 2008 Feb;132(2):265-7
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  • [Title] Composite adenomatoid tumor and myelolipoma of adrenal gland: report of 2 cases.
  • Adenomatoid tumor and myelolipoma are benign, hormonally inactive tumors that are often incidental findings in the adrenal glands.
  • Myelolipoma is more common than adenomatoid tumor in this location but both are rare, and as yet, the pathogenesis of both remains unclear.
  • We report 2 cases of composite adenomatoid tumor and myelolipoma, incidentally found in the adrenal gland on investigation for other diseases.
  • To our knowledge, composite adenomatoid tumor and myelolipoma of adrenal gland has not been previously reported.

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  • (PMID = 18251587.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Kalyani R, Das S: Adenomatatoid tumor: Cytological diagnosis of two cases. J Cytol; 2009 Jan;26(1):30-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatatoid tumor: Cytological diagnosis of two cases.
  • Adenomatoid tumor is a benign neoplasm of mesothelial cell origin that occurs in both male and female genital tracts.
  • Fine needle aspiration cytology has an important role in the preoperative diagnosis of the male genital adenomatoid tumor and is a rapid, reliable, conclusive, and cost-effective diagnostic tool that can be used to take appropriate surgical decisions.

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  • (PMID = 21938146.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3167987
  • [Keywords] NOTNLM ; Adenomatoid tumor / FNAC / epididymis / testis
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47. Ribeiro BF, Iglesias DP, Nascimento GJ, Galvão HC, Medeiros AM, Freitas RA: Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor. Oral Dis; 2009 Oct;15(7):472-7

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  • [Title] Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor.
  • OBJECTIVE: The aim of this study was to evaluate and compare the expression of metalloproteinases-1, -2, and -9 in solid ameloblastoma and adenomatoid odontogenic tumor.
  • METHODS: A total of 20 cases of solid ameloblastoma and 10 cases of adenomatoid odontogenic tumors were selected and immunohistochemically assessed.
  • RESULTS: Matrix metalloproteinase (MMP)-1 showed a predominant expression in both tumors and was found in stroma and parenchyma.
  • For MMP-2, there was a varied expression, with 80% and 60% of immunoreactive tumor cells in ameloblastoma and adenomatoid odontogenic tumor respectively.
  • Regarding stromal cells, 65% of ameloblastomas and 80% of adenomatoid odontogenic tumors showed positivity.
  • There was immunoexpression of the MMP-9 in parenchymal and stromal cells in all cases of both tumors analyzed.
  • CONCLUSION: The results suggest that these metalloproteinases are related to growth and progression of tumors analyzed, and particularly in ameloblastoma, its highest aggressiveness may be, in part, a result of the active participation of the stromal cells and their products, such as the MMPs studied.
  • [MeSH-major] Ameloblastoma / metabolism. Matrix Metalloproteinase 1 / biosynthesis. Matrix Metalloproteinase 2 / biosynthesis. Matrix Metalloproteinase 9 / biosynthesis. Odontogenic Tumors / metabolism

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  • (PMID = 19522745.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.7 / Matrix Metalloproteinase 1
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48. Sayed DM, el-Attar MM, Hussein AA: Evaluation of flow cytometric immunophenotyping and DNA analysis for detection of malignant cells in serosal cavity fluids. Diagn Cytopathol; 2009 Jul;37(7):498-504
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  • The serosal cavities are frequent sites of tumor metastasis.
  • The distinction between carcinoma cells, inflammatory cells, and reactive or malignant mesothelial cells can be difficult in cytology.
  • In this study, we aimed to assess the diagnostic accuracy of FCM immunophenotyping and DNA in comparison with serum tumor markers and classic cytology for detection of malignant cells in pleural and ascitic fluids.
  • The mean of DI differed statistically in patients with malignant effusions than in benign one.
  • DI showed no difference in fluids due to infiltration of malignant epithelial cells or hematopoietic malignancy or due to hepatocellular carcinoma developing in cirrhotic liver.
  • [MeSH-major] DNA, Neoplasm / genetics. Flow Cytometry / methods. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neoplasms / genetics. Neoplasms / metabolism. Neoplasms / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19217060.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neoplasm Proteins
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49. Minhas K, Barakzai A, Qureshi A: Fibromatous periorchitis. J Pak Med Assoc; 2009 Jan;59(1):47-9
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  • Although fibrous pseudotumours of this region are uncommon, they are reported to be the second most common benign paratesticular lesion after adenomatoid tumours.

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  • (PMID = 19213380.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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50. Bhalla R, Siddiqui MT, Mandich D, Cartun RW, Fiel-Gan MD, Nassar A, Mandavilli SR: Diagnostic utility of D2-40 and podoplanin in effusion cell blocks. Diagn Cytopathol; 2007 Jun;35(6):342-7
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  • The distinction between malignant mesothelioma and adenocarcinoma is a diagnostic challenge in cytologic specimens of effusion fluids.
  • As for today, no single antibody has demonstrated absolute sensitivity or specificity for Mesothelioma.
  • D2-40 and podoplanin have recently been recognized to stain mesothelial cells.
  • Our aim for this study was to evaluate the utility of these two markers as indicators of mesothelial cells using cell blocks by comparison with two other established mesothelial markers.
  • A total of 40 cell blocks of effusion fluids including cases of epithelioid mesotheliomas, metastatic carcinomas and benign cases with reactive mesothelial cells were selected.
  • D2-40 and podoplanin were positive in 100% of mesothelioma cases in comparison to metastatic adenocarcinoma cases where the positivity was 0%.
  • It is concluded that D2-40 and podoplanin are very useful markers for mesotheliomas.
  • Since these markers are extremely helpful in differentiating epithelioid mesothelioma from metastatic adenocarcinoma, they shall be a valuable addition to the battery of markers used to differentiate the two entities.
  • [MeSH-major] Antibodies, Neoplasm. Mesothelioma / diagnosis. Pleural Effusion, Malignant / diagnosis

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  • (PMID = 17497664.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm
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51. Bhatt S, Rubens DJ, Dogra VS: Sonography of benign intrascrotal lesions. Ultrasound Q; 2006 Jun;22(2):121-36
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  • [Title] Sonography of benign intrascrotal lesions.
  • Ultrasound plays an important role and adds essential information in diagnosing benign intrascrotal lesions.
  • Characterization of benign intrascrotal lesions with sonography, in combination with clinical assessment, can lead to nonsurgical management or testicular sparing surgery.
  • We present important sonographic features of benign intrascrotal lesions, including extratesticular lesions: adenomatoid tumors, papillary cystadenomas, spermatoceles, hydroceles, varicoceles, hernias; and intratesticular lesions: tunica albuginea cysts, testicular simple cysts, epidermoid cysts, tubular ectasia of the rete testis, intratesticular varicoceles, adrenal rest tumors, and splenogonadal fusion.
  • The goal of this review is to provide the radiologist with a better understanding of benign lesions that occur in the scrotum.

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  • (PMID = 16783242.001).
  • [ISSN] 0894-8771
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 73
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52. Afify AM, Stern R, Michael CW: Differentiation of mesothelioma from adenocarcinoma in serous effusions: the role of hyaluronic acid and CD44 localization. Diagn Cytopathol; 2005 Mar;32(3):145-50
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  • [Title] Differentiation of mesothelioma from adenocarcinoma in serous effusions: the role of hyaluronic acid and CD44 localization.
  • Differentiating cells of mesothelial origin from adenocarcinoma (ACA) based on morphology alone can be a diagnostic challenge, especially in cytological specimens.
  • Malignant mesothelioma (MM) is characterized by accumulation of abundant intracellular hyaluronic acid (HA), a feature that is not reported in ACA.
  • Archival paraffin-embedded cell blocks of serous fluids from 28 cases of reactive mesothelial cells, 14 cases of MM, 20 cases of metastatic ovarian carcinomas, 17 cases of metastatic breast carcinomas, 12 cases of metastatic lung ACA, and 12 cases of metastatic gastrointestinal ACA were stained with HA using a biotinylated HABP and CD44S.
  • All MMs and 93% (26/28) of the benign mesothelial cells were positive for intracytoplasmic HA vs. none of ACAs.
  • CD44S was expressed in 100% (28/28) of mesothelial hyperplesia, 86% (12/14) of MMs, 70% (14/20) of ovarian carcinomas, 29% (5/17) of breast carcinomas, 25% (3/12) of gastrointestinal ACAs, and 8% (1/12) of lung ACAs.
  • In MM and reactive mesothelial cells, CD44S stained cell membranes diffusely with highlights on the villous surfaces and in ACA it was focal and confined to cell membranes.
  • Immunostaining with HA is a reliable marker that can distinguish between cells of mesothelial origin (reactive mesothelial cells and MM) and ACA.
  • The CD44S staining pattern of cells of mesothelial origin is of diagnostic significance.
  • CD44 may prove useful in conjunction with other stains in the differential diagnosis of mesothelioma and ADA.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antigens, CD44 / metabolism. Ascitic Fluid / metabolism. Hyaluronic Acid / metabolism. Mesothelioma / diagnosis. Pleural Effusion, Malignant / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neoplasm Metastasis. Staining and Labeling

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15690337.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44S antigen; 9004-61-9 / Hyaluronic Acid
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53. Butnor KJ: My approach to the diagnosis of mesothelial lesions. J Clin Pathol; 2006 Jun;59(6):564-74
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  • [Title] My approach to the diagnosis of mesothelial lesions.
  • Mesothelial lesions pose considerable diagnostic challenges not only because benign tumours, reactive proliferations and malignant mesothelioma can mimic one another, but also because the morphological patterns displayed by malignant mesothelioma can simulate a variety of epithelial and non-epithelial malignancies.
  • Immunohistochemical markers can aid in distinguishing epithelioid malignant mesothelioma from metastatic adenocarcinoma, but because no single marker reliably separates all cases, a panel of stains is recommended.
  • Immunohistochemical studies are of more limited value in sarcomatoid malignant mesothelioma, and other features often play an essential role.
  • The separation of reactive mesothelial proliferations from malignant mesothelioma on small biopsy can be quite difficult, as distinguishing features, such as stromal invasion, often cannot be adequately assessed.
  • In adequately sampled lesions, however, the distinction between malignant mesothelioma, benign mesothelial proliferations and other tumours can be achieved in most cases by using a carefully integrated approach that incorporates clinical and radiographic data, immunohistochemical studies and, in selected cases, histochemical and ultrastructural techniques.
  • [MeSH-major] Mesothelioma / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / secondary. Biomarkers, Tumor / metabolism. Cell Proliferation. Diagnosis, Differential. Epithelium / pathology. Humans

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  • (PMID = 16731600.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC1860395
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54. Tursi M, Martinetti M, Gili S, Muscio M, Gay L, Crudelini M, Cenacchi G, Pucci A: Myocardial adenomatoid tumor in eight cattle: evidence for mesothelial origin of bovine myocardial epithelial inclusions. Vet Pathol; 2009 Sep;46(5):897-903
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myocardial adenomatoid tumor in eight cattle: evidence for mesothelial origin of bovine myocardial epithelial inclusions.
  • The adenomatoid tumor is an uncommon benign lesion, thus far described only in humans.
  • Adenomatoid tumors typically arise in the genital tract, exceptionally in the heart, and usually represent an incidental finding.
  • Mesothelial origin of these lesions is suggested by their immunohistochemical characteristics.
  • In cattle, previously reported myocardial epithelial inclusions are morphologically similar in that the cells are immunoreactive for both cytokeratins and vimentin, and bear surface microvilli.
  • Myocardial lesions found incidentally at slaughter in 8 cattle histologically resembled the so-called bovine myocardial epithelial inclusions and had morphologic and immunohistochemical features consistent with human adenomatoid tumor.
  • All lesions were in the left ventricular myocardium, adjacent to the epicardium, and composed of epithelioid cells that formed cords and tubules, and were immunoreactive for pan-cytokeratins, cytokeratin 5/6, vimentin, calretinin, Wilms' tumor 1 suppressor gene, and CD30 antigen.
  • The immunohistochemical and ultrastructural features were considered consistent with mesothelial origin.
  • These lesions, corresponding to the previously described myocardial epithelial inclusions in cattle, might be considered embryologic rests and could represent the bovine counterpart of the human adenomatoid tumor.
  • [MeSH-major] Adenomatoid Tumor / veterinary. Cattle Diseases / pathology. Heart Neoplasms / veterinary. Neoplasms, Mesothelial / veterinary

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  • (PMID = 19430001.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Sieunarine K, Cowie AS, Bartlett JD, Lindsay I, Smith JR: A novel approach in the management of a recurrent adenomatoid tumor of the uterus utilizing a Strassman technique. Int J Gynecol Cancer; 2005 Jul-Aug;15(4):671-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel approach in the management of a recurrent adenomatoid tumor of the uterus utilizing a Strassman technique.
  • Adenomatoid tumors of the uterus are uncommon benign lesions derived from mesothelium, with a prevalence of 1.2% in one study of 1 000 unselected hysterectomy specimens.
  • They are usually small and near the serosal surface; however, they may be large and diffuse (giant adenomatoid tumors).
  • This transpired to be an adenomatoid tumor, and she underwent three transcervical resections of the tumor (TCRT) over a period of 12 months for tumor recurrence and failure of symptom resolution.
  • A specialist opinion on the suitability of vascular embolization of the tumor judged that it would be ineffective for this lesion.
  • She then underwent a Strassman procedure and removal of the adenomatoid tumor.
  • This involved dissection of ureters and pelvic vasculature, selective temporary ligation of uterine arteries, hemisection of the uterus, and excision of the tumor with frozen sections to ensure clear tumor margins and resuturing of the uterine halves.
  • Temporary vascular occlusion of the uterine arteries and ovarian vessels allowed a Strassman procedure, which resulted in successful resection of a recurrent giant adenomatoid tumor of the uterus, with fertility preservation in a young nulliparous woman.
  • Two and a half years on there is no evidence of tumor recurrence.
  • [MeSH-major] Adenomatoid Tumor / surgery. Gynecologic Surgical Procedures / methods. Neoplasm Recurrence, Local / surgery. Uterine Neoplasms / surgery. Uterus / blood supply

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  • (PMID = 16014122.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Mitsui Y, Ueda Y, Suzuki T, Shincho M, Higuchi Y, Qiu J, Maruyama T, Kondoh N, Nojima M, Yamamoto S, Hirota S, Shima H: [A case of adenomatoid tumor of the testis treated by testis-sparing surgery: a case report]. Hinyokika Kiyo; 2008 May;54(5):383-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of adenomatoid tumor of the testis treated by testis-sparing surgery: a case report].
  • A 44-year-old man was referred to our hospital with a chief complaint of a painless left intrascrotal mass, palpable at the lower portion of the left testis.
  • Serum levels of tumor markers, human choriogenic gonadotropin (hCG), hCG-beta, and alpha fetoprotein were within the normal limits.
  • Ultrasonography revealed a hyperechoic mass 13 mm in diameter, which was demonstrated as a hypovascular tumor by Gadrinium-enhanced magnetic resonance imaging.
  • Since the tumor was diagnosed as a benign tumor by frozen section examination intraoperatively, testis-sparing surgery was performed.
  • Histological examination revealed adenomatoid tumor originating from the tunica alubuginea of testis.
  • Adenomatoid tumor of the testis is a rare benign tumor, and the present case is the 36th one in the Japanese literature.
  • [MeSH-major] Adenomatoid Tumor / surgery

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  • (PMID = 18546867.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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57. Arsene D, Georgescu A, Dănăilă L, Ardeleanu C: Giant intracranial endolymphatic sac tumor (ELST). Case presentation and histogenetic considerations. Rom J Morphol Embryol; 2008;49(1):85-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant intracranial endolymphatic sac tumor (ELST). Case presentation and histogenetic considerations.
  • We present a giant tumor of the skull base compressing the brain in a 40-years-old man.
  • The tumor was policystic at imaging.
  • Its histopathology, immunohistochemical profile and long evolution suggest an endolymphatic sac tumor (ELST), a rare case of neoplasia.
  • This could be from either the organ of Corti or some local cells that generate a resemblance with a systemic tumor, the so-called benign mesothelioma.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Humans. Male. Tumor Burden

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  • (PMID = 18273509.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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58. Pacheco AJ, Torres JL, de la Guardia FV, Arrabal Polo MA, Gómez AZ: Intraparenchymatous adenomatoid tumor dependent on the rete testis: A case report and review of literature. Indian J Urol; 2009 Jan;25(1):126-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraparenchymatous adenomatoid tumor dependent on the rete testis: A case report and review of literature.
  • The adenomatoid tumor is the most frequent paratesticular tumor.
  • It is a benign tumor, which in women is mainly found in the uterus and the fallopian tubes, while in men it is most frequently found in the epididymis.
  • The clinical signs and imaging studies are, on many occasions, difficult to differentiate from malign intratesticular solid tumor, which can result in unnecessary orchidectomies.
  • We present a new case of intraparenchymatous adenomatoid tumor dependent on the rete testis.

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  • [Cites] Eur Urol. 1996;30(1):127-8 [8854081.001]
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  • (PMID = 19468443.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2684313
  • [Keywords] NOTNLM ; Adenomatoid tumor / diagnosis and ultrasound
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59. Burel-Vandenbos F, Cardot-Leccia N, Effi B, Varini JP, Saint-Paul MC, Michiels JF: [An unusual tumor of the adrenal gland]. Ann Pathol; 2005 Oct;25(5):386-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An unusual tumor of the adrenal gland].
  • [Transliterated title] Une tumeur inhabituelle de la surrénale.
  • Adenomatoid tumors are benign mesothelial tumors that usually affect the genital tract.
  • We report the case of a 65-year-old man with an adenomatoid tumor of the adrenal gland.
  • This uncommon location and its histological heterogeneity can lead to a mistaken diagnosis of malignant tumor.
  • Positive cells with mesothelial markers in immunohistochemistry improve diagnosis.
  • The proper identification of this benign tumor in the adrenal gland and the knowledge of its differential diagnosis deserve attention to avoid invasive treatment.
  • [MeSH-major] Adenomatoid Tumor / pathology. Adrenal Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adrenalectomy. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Lymphangioma / diagnosis. Male. Neoplasm Proteins / analysis

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  • (PMID = 16498291.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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60. Duval H, Rioux-Leclercq N, Bauville E, Al Jaradi M, Burtin F: [Multinodular-adenomatoid tumor of the uterus in a patient with a renal allograft]. Ann Pathol; 2008 Sep;28(4):308-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multinodular-adenomatoid tumor of the uterus in a patient with a renal allograft].
  • [Transliterated title] Tumeur adénomatoïde multinodulaire de l'utérus chez une patiente avec allogreffe rénale.
  • A case of diffuse-adenomatoid tumor of the uterus occurring in a 43-year-old patient with a renal-allograft transplant is reported.
  • The diagnosis was supported by the adenomatoid and angiomatoid histologic patterns and the mesothelial immunophenotype.
  • Diffuse-adenomatoid tumor of the uterus is a rare and benign lesion, usually reported in patients with immunodeficiency and renal transplant.

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  • (PMID = 18928872.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G
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61. Thamboo TP, Sim R, Tan SY, Yap WM: Primary retroperitoneal mucinous cystadenocarcinoma in a male patient. J Clin Pathol; 2006 Jun;59(6):655-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The 64-year-old man presented with a large retroperitoneal cystic tumour measuring 24 x 20 x 16 cm3, which was removed intact.
  • Areas ranging from a benign mucinous cyst to borderline mucinous tumour to mucinous cystadenocarcinoma were observed on microscopy.
  • Strong patchy staining for cytokeratins 7 and 20 and strong diffuse staining for MUC2 and MUC5AC core peptides, similar to staining patterns in ovarian mucinous tumours, were shown in the benign and atypical epithelium.
  • The theory of its origin from the mucinous metaplasia of peritoneal (mesothelial) inclusion cysts, rather than from ectopic ovarian tissue or ovarian teratomas, is supported by the occurrence of such a tumour in a male patient.
  • [MeSH-minor] Humans. Keratins / metabolism. Male. Middle Aged. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 16731606.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 15
  • [Other-IDs] NLM/ PMC1860402
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62. Chiappino G: [Mesothelioma: the aetiological role of ultrathin fibres and repercussions on prevention and medical legal evaluation]. Med Lav; 2005 Jan-Feb;96(1):3-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mesothelioma: the aetiological role of ultrathin fibres and repercussions on prevention and medical legal evaluation].
  • [Transliterated title] Mesotelioma: il ruolo delle fibre ultrafini e conseguenti riflessi in campo preventivo e medico legale.
  • BACKGROUND: Mesothelioma has until now been considered to be a manifestation, occurring in the pleura and/or peritoneum, of the carcinogenic action of the total burden of inhaled asbestos fibres, in the same way as lung cancer.
  • Because of the pathogenic potential of very low exposure levels, the fact that the onset of the neoplasm always occurs in the parietal pleura, and the absence of any synergism with smoking, which is typical in the case of carcinoma, it was suspected that aetiopathogenetic differences existed but the reasons for such differences still could not be explained.
  • In the past experimental results indicated the oncogenicity of very thin fibres but mesothelioma in practice was not exclusively linked to this specific dimensional size class.
  • OBJECTIVES: The paper proposes to take full advantage of the significant knowledge that must emerged from research carried out in recent years and use this knowledge to reconstruct the mosaic of the aetiopathogenesis of mesothelioma.
  • RESULTS: The most important knowledge that must today be taken as certain is the fact that mesothelioma is not caused, as is the case for asbestosis, by all the fibres that are inhaled but only by the ultrathin fraction of these fibres, having diameter of 0.2 microm and length of only a few microm.
  • Only fibres of this class of size can cross the pulmonary-pleural barrier and are, therefore, the causal agent of mesothelioma and other benign pleural manifestations (plaques).
  • Due to their shape, the fibres cannot easily be absorbed into the stoma via the lymphatic flow and so remain clustered for an indefinite period of time among the mesothelial cells that surround the stoma.
  • The concentration of ultrathin fibres in punctiform areas of the parietal pleura and the extremely long biopersistence of the amphiboles now finally explain how very low exposures can cause mesothelioma in susceptible subjects and why the neoplasm always occurs on the parietal pleura.
  • CONCLUSIONS: In medical-legal assessments of cases of mesothelioma the etiological importance of the ultrathin fraction of fibres means that any assumption of the disease being avoidable must be discarded, at least up to the second half of the 1980s because until then this class of fibres, which today must be considered as the true causal agent of the neoplasm, was not visible under the optical microscope, nor could such fibres be measured or eliminated from the atmosphere of working environments.
  • [MeSH-major] Mesothelioma / etiology. Mesothelioma / prevention & control. Pleural Neoplasms / etiology. Pleural Neoplasms / prevention & control

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  • [CommentIn] Med Lav. 2005 May-Jun;96(3):262; author reply 264-6 [16273846.001]
  • [CommentIn] Med Lav. 2005 May-Jun;96(3):263-4; author reply 264-6 [16273847.001]
  • (PMID = 15847104.001).
  • [ISSN] 0025-7818
  • [Journal-full-title] La Medicina del lavoro
  • [ISO-abbreviation] Med Lav
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Mineral Fibers; 1332-21-4 / Asbestos
  • [Number-of-references] 54
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63. Minato H, Nojima T, Kurose N, Kinoshita E: Adenomatoid tumor of the pleura. Pathol Int; 2009 Aug;59(8):567-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatoid tumor of the pleura.
  • A case of adenomatoid tumor of the pleura is reported, and its differential diagnosis from benign and malignant pleural lesions is discussed.
  • A 7 mm, circumscribed tumor had characteristic features of adenomatoid tumor.
  • The tumor was composed of an aggregation of irregularly shaped tubulocystic spaces with fibrous stoma.
  • On immunohistochemistry the tumor cells were positive for AE1/AE3, CAM5.2, vimentin, cytokeratin 5/6, D2-40, calretinin, thrombomodulin, and WT-1, but negative for CEA, Leu M1 (CD15), thyroid transcription factor-1, epithelial membrane antigen, desmin, glucose transporter-1 (GLUT-1), CD31, and CD34.
  • Adenomatoid tumor of the pleura is rare, and the pathogenesis has not been elucidated.
  • Recognition of these benign mesothelial lesions in the pleura is important to avoid misdiagnosis.
  • The immunohistochemistry in the present case supports its mesothelial origin.
  • [MeSH-major] Adenomatoid Tumor / pathology. Neoplasms, Multiple Primary / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Dermatomyositis / complications. Esophageal Neoplasms / complications. Esophageal Neoplasms / pathology. Female. Humans. Immunohistochemistry. Incidental Findings. Liver Cirrhosis, Biliary / complications. Middle Aged

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  • (PMID = 19627540.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. García-González J, Villanueva C, Fernández-Aceñero MJ, Paniagua P: Paratesticular desmoplastic small round cell tumor: case report. Urol Oncol; 2005 Mar-Apr;23(2):132-4
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  • [Title] Paratesticular desmoplastic small round cell tumor: case report.
  • BACKGROUND: The desmoplastic small round cell tumor has recently been separated from other small round cell tumors because of its characteristic pathological and clinical features.
  • They are usually intra-abdominal tumors affecting young people and have classically been associated with a bad prognosis.
  • However, in recent years there have reports on desmoplastic small round cell tumors affecting other body regions, including the paratesticular area.
  • CASE PRESENTATION: We report the case of a 23-year-old male, that consulted on a progressive enlargement of the right hemiscrotum in the last year and a half.
  • Physical examination revealed a round elastic firm 2 to 3 cm mass distal to the tail of the epididymis, which was excised with a preoperative diagnosis of adenomatoid tumor.
  • However, histological and immunohistochemical diagnosis confirmed a desmoplastic small round cell tumor.
  • Today, 6 years after diagnosis the patient remains well and free of disease.
  • CONCLUSIONS: Recent reviews on desmoplastic small round cell tumor affecting the paratesticular area have shown a better prognosis for tumors of this origin compared to abdominal ones.
  • We should include this lesion among the differential diagnosis of paratesticular tumors, mainly in children and adolescents.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease-Free Survival. Humans. Male

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  • (PMID = 15869999.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Kalidindi M, Odejinmi F: Laparoscopic excision of uterine adenomatoid tumour: two cases and literature review. Arch Gynecol Obstet; 2010 Feb;281(2):311-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic excision of uterine adenomatoid tumour: two cases and literature review.
  • INTRODUCTION: Adenomatoid tumours are rare, benign neoplasms of the genital tract, occurring most commonly during the reproductive years.
  • These tumours can be associated with fibroids and tend to mimic them clinically and radiologically, making pre-operative diagnosis very difficult.
  • We report two cases of uterine adenomatoid tumours that were excised laparoscopically.
  • Intraoperatively, there was no clear line of demarcation between the uterus and the tumours and laparoscopic manipulation of the tumours was difficult due to their friable nature.
  • CONCLUSION: Adenomatoid tumours should always be included in the differential diagnosis along with adenomyosis and post-GnRH analogue treatment changes, when difficulty is encountered in identification of operative planes during a routine laparoscopic myomectomy.
  • Apart from explaining the operative difficulties, the identification of these tumours also helps in post-operative counselling of these patients as these tumours unlike fibroids do not recur.
  • [MeSH-major] Adenomatoid Tumor / pathology. Uterine Neoplasms / pathology

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  • (PMID = 19434414.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Davidson B, Skrede M, Silins I, Shih IeM, Trope CG, Flørenes VA: Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma. Cancer; 2007 Sep 15;110(6):1264-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma.
  • BACKGROUND: The authors recently reported on the role of cyclin E in differentiating ovarian/primary peritoneal carcinoma from malignant peritoneal mesothelioma using gene expression arrays.
  • In the current study, they analyzed the expression of low-molecular weight (LMW) forms of cyclin E in ovarian carcinoma, malignant mesothelioma, and benign reactive effusions.
  • METHODS: Cyclin E protein expression was analyzed in 98 effusions (72 ovarian carcinomas, 14 malignant mesotheliomas, and 12 reactive specimens) using immunoblotting.
  • RESULTS: LMW forms of cyclin E were identified in 54 of 72 ovarian carcinoma effusions (75%) compared with 1 of 14 malignant mesothelioma effusions (7%) and 1 of 12 reactive effusions (8%) (P < .001).
  • The presence of a higher percentage of cyclin E-positive cells using immunohistochemistry was correlated with shorter progression-free survival (P = .026).
  • CONCLUSIONS: LMW forms of cyclin E differentiated ovarian carcinoma from benign and malignant mesothelial cells and were associated with increased protein expression using immunohistochemistry.
  • The expression of LMW cyclin E forms was not associated with chemotherapy response, although it may be a marker of aggressive disease in patients with metastatic ovarian carcinoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / chemistry. Carcinoma / mortality. Cyclin E / analysis. Mesothelioma / chemistry. Mesothelioma / mortality. Ovarian Neoplasms / chemistry. Ovarian Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Immunoblotting. Immunohistochemistry. Middle Aged. Molecular Weight. Survival Analysis

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17647260.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin E
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67. Wheeler YY, Burroughs F, Li QK: Fine-needle aspiration of a well-differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature. Diagn Cytopathol; 2009 Oct;37(10):748-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration of a well-differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature.
  • Well-differentiated papillary mesothelioma (WDPM) is an uncommon subtype of epithelioid mesothelioma.
  • In contrast to malignant epithelioid mesothelioma, WDPM has a low malignant potential and an indolent clinical course.
  • WDPM may be difficult to diagnose and differentiate from benign reactive mesothelial cells and other malignant neoplasm on cytology specimens due to the presence of papillary or tubulopapillary clusters of tumor cells.
  • We report a case of a 63-year-old Asian male with a slowly growing left inguinal hernia mass for several years and a concurrent 8 cm mass in the peritoneal wall.
  • The cytology of ultrasound-guided fine-needle aspiration (FNA) of the left inguinal hernia and peritoneal masse reveal cellular specimens with numerous individual and tubulopapillary clusters of epithelioid mesothelial cells in a background of scant hyalinized material.
  • Tumor cells show minimal cytological atypia.
  • The differential diagnoses are broad and include reactive mesothelial cells, WDPM, and other malignant neoplasm.
  • It is important to recognize this entity in the differential diagnosis, because the clinical management of WDPM is quite different from that of malignant neoplasm.
  • [MeSH-major] Hernia, Inguinal / pathology. Inguinal Canal / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19373910.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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68. Young RH: Testicular tumors--some new and a few perennial problems. Arch Pathol Lab Med; 2008 Apr;132(4):548-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular tumors--some new and a few perennial problems.
  • The histopathology of testicular tumors is presented, emphasizing new, unusual, or underemphasized aspects.
  • Within the category of seminoma of the usual type, the recent literature has drawn attention to the presence in occasional tumors of solid or hollow tubules or spaces of varying sizes and shape that may result in cribriform or microcystic patterns, causing potential confusion with other neoplasms, most notably Sertoli cell tumor or yolk sac tumor.
  • Although regions of typical neoplasia and awareness of this phenomenon usually will be diagnostic, immunohistochemistry may play a role in excluding Sertoli cell tumor or yolk sac tumor.
  • Although immunohistochemistry can play an undoubted helpful role in this and selected other areas of testicular tumor evaluation, careful evaluation of the gross and routine microscopic features will solve the vast majority of diagnostic problems.
  • Spermatocytic seminoma remains a crucial pitfall in diagnosis, and the pathologist must always be alert to the possible diagnosis when looking at a seminomatous neoplasm, particularly in an older patient, although about one third of these tumors occur in the usual seminoma age range.
  • The enigmatic and picturesque tumor, polyembryoma, which virtually never occurs in pure form but may be a confusing component of a variety of mixed germ cell tumors, is discussed and illustrated.
  • Within the sex cord-stromal family of neoplasms, recent contributions and elaborations of unusual morphologic features of Leydig cell tumors and Sertoli cell tumors are presented.
  • The peculiar lesion, intratubular large cell hyalinizing Sertoli cell tumor, of young boys with Peutz-Jeghers syndrome, is briefly discussed.
  • Although secondary tumors to the testis have not received the same attention in the literature as the similar phenomenon in the female gonad, remarkable examples of testicular spread of diverse neoplasms, usually carcinoma but rarely melanoma, are seen, and the pathologist should be alert to this possibility, particularly when examining an unusual morphology in an older patient.
  • Finally, a few comments are made on the common paratesticular neoplasm, the adenomatoid tumor, highlighting its varied patterns and recent description of some of the issues that may arise when they undergo total or subtotal infarction.
  • [MeSH-minor] Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / pathology. Diagnosis, Differential. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Humans. Male. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / pathology. Seminoma / diagnosis. Seminoma / pathology. Teratoma / diagnosis. Teratoma / pathology

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  • (PMID = 18384207.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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69. Robinson LA: Solitary fibrous tumor of the pleura. Cancer Control; 2006 Oct;13(4):264-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the pleura.
  • BACKGROUND: The solitary fibrous tumor of the pleura (SFTP) is a rare primary tumor arising from mesenchymal cells in the areolar tissue subjacent to the mesothelial-lined pleura.
  • The tumor appears to be unrelated to malignant pleural mesothelioma, the most common primary tumor of the pleura.
  • METHODS: In just over half of these cases, the neoplasm presents as an asymptomatic mass, is often quite large, and is benign in 78% to 88% of patients.
  • The initial evaluation and diagnosis, tumor classification, surgical treatment, results of therapy, and long-term prognosis are reviewed, based on a selective review of the literature from MEDLINE beginning 1980.
  • RESULTS: Complete en bloc surgical resection is the preferred treatment of benign and malignant varieties of the tumor.
  • The pedunculated tumors attached to the visceral pleura can be effectively treated with a wedge resection of lung.
  • Sessile tumors arising on the lung require a larger lung resection.
  • Sessile tumors on the chest wall require wide local excision, often with chest wall resection because of their propensity for local recurrence.
  • CONCLUSIONS: Benign SFTP has a high cure rate and an 8% local recurrence rate that is usually amenable to curative re-excision.
  • The majority of patients with recurrent disease die of the tumor within 2 years.

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  • (PMID = 17075563.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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70. Reich R, Vintman L, Nielsen S, Kaern J, Bedrossian C, Berner A, Davidson B: Differential expression of the 67 kilodalton laminin receptor in epithelioid malignant mesothelioma and carcinomas that spread to serosal cavities. Diagn Cytopathol; 2005 Nov;33(5):332-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of the 67 kilodalton laminin receptor in epithelioid malignant mesothelioma and carcinomas that spread to serosal cavities.
  • Expression of the 67-kd laminin receptor (67-kd LR) has been reported in a wide range of carcinomas, in many of which it correlated with poor differentiation, metastasis, disease progression, and poor survival.
  • Malignant mesothelioma (MM) is a locally aggressive and highly lethal tumor of serosal cavities that is rarely associated with clinically detectable metastasis to distant organs.
  • Protein expression of the 67-kd LR was frequently detected in carcinomas (19/24 ovarian tumors, 79%; 15/38 breast tumors, 39%), but was rare in MM (2/24 cases, 8%), despite the presence of mRNA transcripts for the receptor in all 21 specimens studied using RT-PCR.
  • Nine benign effusions that were additionally studied for protein expression were uniformly negative, as were all reactive mesothelial cells in malignant effusions.
  • They additionally suggest that the failure of MM to express the 67-kd LR protein, as opposed to the frequent expression in carcinomas with proven metastatic capacity, may be one of the factors contributing to the reduced ability of the former tumor to metastasize to distant organs.
  • [MeSH-major] Adenocarcinoma / metabolism. Ascitic Fluid / metabolism. Mesothelioma / metabolism. Pleural Effusion, Malignant / metabolism. Receptors, Laminin / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Female. Humans. Male. Middle Aged. Molecular Weight. Neoplasm Invasiveness. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. RNA, Messenger / biosynthesis

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  • (PMID = 16240397.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Laminin
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71. Tamai K, Togashi K, Ito T, Morisawa N, Fujiwara T, Koyama T: MR imaging findings of adenomyosis: correlation with histopathologic features and diagnostic pitfalls. Radiographics; 2005 Jan-Feb;25(1):21-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomyosis is a nonneoplastic condition, characterized by benign invasion of ectopic endometrium into the myometrium with hyperplasia of adjacent smooth muscle.
  • Furthermore, malignancy occasionally develops in otherwise benign adenomyosis.
  • Pitfalls in diagnosis of adenomyosis include myometrial contractions, leiomyoma, adenomatoid tumor, metastases, endometrial carcinoma, and endometrial stromal sarcoma.

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  • [Copyright] (c) RSNA, 2005.
  • (PMID = 15653584.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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72. Amin W, Parwani AV: Adenomatoid tumor of testis. Clin Med Pathol; 2009;2:17-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatoid tumor of testis.
  • Adenomatoid tumors are responsible for 30% of all paratesticular masses.
  • They are benign tumors comprising of cords and tubules of cuboidal to columnar cells with vacuolated cytoplasm and fibrous stroma.
  • They are considered to be of mesothelial origin supported by histochemical studies and genetic analysis of Wilms tumor 1 gene expression.
  • Diagnostic studies include serum tumor markers (negative alpha fetoprotein, beta HCG, LDH) ultrasonography (hypoechoic and homogenous appearance) and frozen section.

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  • (PMID = 21151545.001).
  • [ISSN] 1178-1181
  • [Journal-full-title] Clinical medicine. Pathology
  • [ISO-abbreviation] Clin Med Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2990235
  • [Keywords] NOTNLM ; adenomatoid tumor / paratesticluar masses
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73. Koren J, Cunderlík P: [Adenomatoid tumor of the right adrenal gland: a case report]. Cesk Patol; 2005 Jul;41(3):111-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid tumor of the right adrenal gland: a case report].
  • [Transliterated title] Adenomatoidný tumor pravej nadoblicky: kazuistika.
  • Adenomatoid tumor of adrenal gland is a very rare primary tumor with favourable prognosis.
  • The mesothelial origin of this tumor was confirmed by multiple studies of various authors.
  • In our case report, we present an interesting case of the adenomatoid tumor of the right adrenal gland in a 55-year-old woman.
  • Our case is the second well-documented case of this tumor occurring in a female adult patient.
  • We emphasize the presence of an intraluminal thread-like bridging strands, generally considered to be a characteristic histologic feature of this tumor, which have not yet been reported in literature in adenomatoid tumor located in adrenal glands.
  • [MeSH-major] Adenomatoid Tumor / pathology. Adrenal Gland Neoplasms / pathology

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  • (PMID = 16161457.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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74. Addis B, Roche H: Problems in mesothelioma diagnosis. Histopathology; 2009 Jan;54(1):55-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Problems in mesothelioma diagnosis.
  • Many centres are now seeing increasing numbers of patients with malignant mesothelioma.
  • This presents pathologists involved in making the diagnosis with a number of problems, which can be divided into those encountered in making the distinction between mesothelioma and benign changes and those experienced in separating mesotheliomas from other types of epithelial and connective tissue tumours.
  • Immunohistochemistry plays a major role in helping to make the diagnosis, but it should be interpreted with due regard to the clinical setting and radiological features, and with a knowledge of the wide morphological variations seen in mesothelioma.
  • It includes a discussion of some of the less common variants of mesothelioma and other pleural-based tumours that enter into the differential diagnosis.
  • [MeSH-major] Mesothelioma / diagnosis

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  • (PMID = 19054156.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 101
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75. Kontos S, Fokitis I, Karakosta A, Koritsiadis G, Mitsios K, Koutsikos S, Koritsiadis S: Adenomatoid tumor of epididymidis: A case report. Cases J; 2008;1(1):206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatoid tumor of epididymidis: A case report.
  • BACKGROUND: Adenomatoid tumors are regarded as distinctive benign mesothelial neoplasms of the paratesticular region, most commonly occuring at the tail of the epididymidis.Because of its rarity, the clinical and histopathological aspects are discussed.
  • CASE PRESENTATION: We present the case of a 41-year-old patient with an adenomatoid tumour located in the tail of the left epididymis that referred to our department with gradual enlarged intrascrotal mass.

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  • (PMID = 18831762.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2566564
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76. Crippa S, Di Bella C, Faravelli A: Skin adnexal neoplasm closely resembling adenomatoid tumor: a unique occurrence. Int J Surg Pathol; 2006 Apr;14(2):177-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin adnexal neoplasm closely resembling adenomatoid tumor: a unique occurrence.
  • We describe a primary skin neoplasm located in the left chest wall that closely resembled adenomatoid tumor of male and female genital tract.
  • The tumor involved the dermis and subcutaneous tissue and measured 0.7 cm in greatest diameter.
  • We are unaware of a previous description of this morphologic pattern in a primary skin tumor, which we have interpreted as of skin adnexal and specifically of eccrine sweat gland origin.
  • [MeSH-minor] Adenomatoid Tumor / pathology. Aged. Breast Neoplasms / surgery. Carcinoma, Ductal / surgery. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 16703184.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C: Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors. Clin Cancer Res; 2007 Jul 15;13(14):4191-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors.
  • PURPOSE: CD26 is a 110-kDa cell surface antigen with a role in tumor development.
  • In this report, we show that CD26 is highly expressed on the cell surface of malignant mesothelioma and that a newly developed humanized anti-CD26 monoclonal antibody (mAb) has an inhibitory effect on malignant mesothelioma cells in both in vitro and in vivo experiments.
  • EXPERIMENTAL DESIGN: Using immunohistochemistry, 12 patients' surgical specimens consisting of seven malignant mesothelioma, three reactive mesothelial cells, and two adenomatoid tumors were evaluated for expression of CD26.
  • The effects of CD26 on malignant mesothelioma cells were assessed in the presence of transfection of CD26-expressing plasmid, humanized anti-CD26 mAb, or small interfering RNA against CD26.
  • The in vivo growth inhibitory effect of humanized anti-CD26 mAb was assessed in human malignant mesothelioma cell mouse xenograft models.
  • RESULTS: In surgical specimens, CD26 is highly expressed in malignant mesothelioma but not in benign mesothelial tissues.
  • Moreover, our in vitro data indicate that humanized anti-CD26 mAb induces cell lysis of malignant mesothelioma cells via antibody-dependent cell-mediated cytotoxicity in addition to its direct anti-tumor effect via p27(kip1) accumulation.
  • In vivo experiments with mouse xenograft models involving human malignant mesothelioma cells show that humanized anti-CD26 mAb treatment drastically inhibits tumor growth in tumor-bearing mice, resulting in enhanced survival.
  • CONCLUSIONS: Our data strongly suggest that humanized anti-CD26 mAb treatment may have potential clinical use as a novel cancer therapeutic agent in CD26-positive malignant mesothelioma.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Dipeptidyl Peptidase 4 / immunology. Lung Neoplasms / immunology. Mesothelioma / immunology
  • [MeSH-minor] Antigens, CD / genetics. Antigens, CD / immunology. Humans. Immunity, Cellular. Immunohistochemistry. Immunotherapy. Tumor Cells, Cultured

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  • (PMID = 17634548.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD; EC 3.4.14.5 / Dipeptidyl Peptidase 4
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78. Soini Y, Talvensaari-Mattila A: Expression of claudins 1, 4, 5, and 7 in ovarian tumors of diverse types. Int J Gynecol Pathol; 2006 Oct;25(4):330-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of claudins 1, 4, 5, and 7 in ovarian tumors of diverse types.
  • Strong expression of claudins 1, 4, and 7 was seen in benign and malignant epithelial ovarian tumors.
  • Expression of claudin 5, reported to be mainly present in endothelial cells, was seen in ovarian epithelial tumors, but with a significantly lower frequency than claudins 1, 4, and 7.
  • On the contrary, sex-cord stromal tumors and cysts, such as fibromas/thecomas, Sertoli-Leydig cell tumors, granulosa cell tumors, and follicular and luteinized cysts were mainly negative for claudins 1, 4, 5, and 7.
  • Interestingly, adenomatoid tumors did not express claudin 5, which is in agreement with their non-endothelial nature.
  • They were also negative for claudin 4, but expressed claudins 1 and 7, but to a lesser degree than epithelial lesions.
  • In immature teratomas, the epithelial component was usually positive whereas other components were negative for these claudins.
  • The results show that claudins 1, 4, and 7 are mainly expressed in ovarian epithelial tumors and can thus be used to indicate epithelial differentiation in them.
  • Eventhough considered an endothelial marker, claudin 5 was also present in a subset of epithelial lesions.
  • However, this claudin can be used to differentiate adenomatoid tumors from vascular lesions.
  • No significant difference was seen between epithelial benign and malignant lesions, except for claudin 5, which seemed stronger in malignant epithelial tumors.
  • [MeSH-minor] Adenomatoid Tumor / chemistry. Brenner Tumor / chemistry. Carcinoma / chemistry. Claudin-1. Claudin-4. Claudin-5. Claudins. Dysgerminoma / chemistry. Female. Humans. Immunohistochemistry. Krukenberg Tumor / chemistry. Ovarian Cysts. Sex Cord-Gonadal Stromal Tumors / chemistry. Teratoma / chemistry

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  • (PMID = 16990707.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / CLDN4 protein, human; 0 / CLDN5 protein, human; 0 / CLDN7 protein, human; 0 / Claudin-1; 0 / Claudin-4; 0 / Claudin-5; 0 / Claudins; 0 / Membrane Proteins
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79. Cakir C, Gulluoglu MG, Yilmazbayhan D: Cell proliferation rate and telomerase activity in the differential diagnosis between benign and malignant mesothelial proliferations. Pathology; 2006 Feb;38(1):10-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cell proliferation rate and telomerase activity in the differential diagnosis between benign and malignant mesothelial proliferations.
  • AIMS: The differential diagnosis of malignant mesothelioma (MM) from benign mesothelial lesions (BML) based on histopathological criteria is sometimes not satisfying and causes diagnostic problems for histopathologists.
  • METHODS: Sixty-six cases of MM (33 epithelioid, 30 biphasic and 3 sarcomatoid) and 22 cases of BML (15 reactive mesothelial proliferations and 7 fibrous pleuritis/pericarditis) were included in this study.
  • CONCLUSION: As a result, being cheap and simple methods, Ki-67 and hTERT immunohistochemistries can be used in differentiating malignant and benign mesothelial lesions in routine formalin-fixed, paraffin-embedded material.
  • [MeSH-major] Cell Proliferation. Neoplasms, Mesothelial / metabolism. Neoplasms, Mesothelial / pathology. Telomerase / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. DNA-Binding Proteins / metabolism. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Pleurisy / diagnosis. Pleurisy / metabolism. Pleurisy / pathology. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 16484001.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 2.7.7.49 / Telomerase
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80. Carmignani L, Morabito A, Gadda F, Bozzini G, Rocco F, Colpi GM: Prognostic parameters in adult impalpable ultrasonographic lesions of the testicle. J Urol; 2005 Sep;174(3):1035-8
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  • MATERIALS AND METHODS: We performed a bibliographic search on PubMed, MEDLINE, EMBASE online databases from 1990 to May 2004 using search words such as sonographic lesions of the testicle, impalpable tumors of the testicle and impalpable testicular lesions.
  • Six articles were found that presented a description of the histological characteristics, patient age, lesion dimensions, presence of cryptorchidism and association with tumors in other parts of the body.
  • Histologically 15 of the lesions were Leydig cell tumors (31%), 12 (25%) seminomas, 7 (14.5%) nonseminomatous germ cell tumors, 2 (4.5%) Sertoli cell tumors, 12 (25%) benign forms (fibrosis, infarct, lipoma, mesothelial hyperplasia, adenomatoid tumor).
  • Dimension was particularly related to germ cell tumors (for dimensions between 16 and 32 mm relative risk ratio [RRR] = 13.97, p=0.0449).
  • Infertility proved significant in defining stromal tumors (RRR = 9,681, p=0.022) CONCLUSIONS: Although with the limits of a retrospective study consisting in an analysis of individual data, interesting correlations between malignant pathologies and the initial characteristics of impalpable sonographic lesions were revealed.
  • In particular an interesting correlation was found between the dimensions of the lesion and the malignant pathology and between Leydig cell tumor and infertility.

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  • (PMID = 16094042.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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81. Neumann V, Löseke S, Tannapfel A: [Medical insurance aspects of peritoneal tumors with particular attention to peritoneal mesotheliomas]. Med Klin (Munich); 2009 Oct 15;104(10):765-71
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  • [Title] [Medical insurance aspects of peritoneal tumors with particular attention to peritoneal mesotheliomas].
  • [Transliterated title] Versicherungsmedizinische Aspekte bei peritonealen Mesotheliomen und sonstigen peritonealen Tumoren.
  • Malignant peritoneal mesotheliomas arise mainly in male patients and the median age of initial diagnosis is about 56 years.
  • Epitheloid subtype predominates in peritoneal mesotheliomas.
  • Asbestos exposure is the best-known and most common risk factor associated with the development of both pleural and peritoneal mesotheliomas and, therefore, about 90% of cases can be assessed as asbestos-associated.
  • Patients with peritoneal mesotheliomas have distinctly higher asbestos burden of the lungs than patients with pleural mesotheliomas.
  • The mean latency period between exposure and diagnosis of peritoneal mesothelioma ranges from 35 to 40 years and is comparable to that of pleural mesothelioma.
  • Mesothelioma of the tunica vaginalis testis also belongs to the group of peritoneal mesotheliomas.
  • No significant evidence exists for the classification of well-differentiated papillary mesothelioma, solitary fibrous tumor, adenomatoid tumor, primary peritoneal serous borderline tumor, and benign multicystic mesothelioma as asbestos-associated tumors.
  • Except malignant mesotheliomas, the induction of other abdominal tumors is independent of an exposure to asbestos dust.
  • [MeSH-major] Asbestosis / epidemiology. Mesothelioma / epidemiology. National Health Programs / statistics & numerical data. Peritoneal Neoplasms / epidemiology

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  • (PMID = 19856150.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 76
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82. Pu RT, Sheng ZM, Michael CW, Rhode MG, Clark DP, O'Leary TJ: Methylation profiling of mesothelioma using real-time methylation-specific PCR: a pilot study. Diagn Cytopathol; 2007 Aug;35(8):498-502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Methylation profiling of mesothelioma using real-time methylation-specific PCR: a pilot study.
  • We tested whether methylation profiles generated by real-time methylation-specific PCR (MSP) can be useful in differentiating benign, reactive mesothelial cell proliferation (RM) from malignant mesothelioma (MM).
  • [MeSH-major] DNA Methylation. Epithelium / pathology. Mesothelioma / diagnosis. Mesothelioma / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods
  • [MeSH-minor] DNA, Neoplasm / genetics. Female. Humans. Male. Middle Aged. Pilot Projects

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  • [Copyright] Copyright 2007 Wiley-Liss, Inc.
  • (PMID = 17636483.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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83. Manosca F, Schinstine M, Fetsch PA, Sorbara L, Maria Wilder A, Brosky K, Erickson D, Raffeld M, Filie AC, Abati A: Diagnostic effects of prolonged storage on fresh effusion samples. Diagn Cytopathol; 2007 Jan;35(1):6-11
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  • We sought to determine if effusion specimens are suitable for morphologic, immunocytochemical, and DNA-based molecular studies after prolonged periods of refrigerated storage time.
  • Specimens evaluated included four pleural (3 benign, 1 breast adenocarcinoma) and six peritoneal (2 ovarian adenocarcinomas, 1 malignant melanoma, 2 mesotheliomas, 1 atypical mesothelial) effusions.
  • [MeSH-minor] Adult. Biomarkers, Tumor. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. Time Factors

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  • (PMID = 17173298.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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84. Grasso M, Blanco S, Raber M, Nespoli L: Elasto-sonography of the testis: preliminary experience. Arch Ital Urol Androl; 2010 Sep;82(3):160-3
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  • In the remaining 3 cases it allowed a better characterization of 2 small benign tumors and of an intratesticular haematoma.
  • Infact elastosonography resulted helpful in the determination of 2 small lesions diagnosticated after surgery as Sertoli tumor and adenomatoid tumor of the testis, respectively in a third case the elastosonography identified an intraparenchimal hematoma (confirmed after surgical exploration )in the differential diagnosis with a solid tumor.

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  • (PMID = 21121434.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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85. Kurman RJ, Shih IeM: The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol; 2010 Mar;34(3):433-43
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  • [Title] The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
  • Efforts at early detection and new therapeutic approaches to reduce mortality have been largely unsuccessful, because the origin and pathogenesis of epithelial ovarian cancer are poorly understood.
  • This has led to the proposal that ovarian cancer develops de novo.
  • Studies have shown that epithelial ovarian cancer is not a single disease but is composed of a diverse group of tumors that can be classified based on distinctive morphologic and molecular genetic features.
  • One group of tumors, designated type I, is composed of low-grade serous, low-grade endometrioid, clear cell, mucinous and transitional (Brenner) carcinomas.
  • These tumors generally behave in an indolent fashion, are confined to the ovary at presentation and, as a group, are relatively genetically stable.
  • Moreover, the carcinomas exhibit a shared lineage with the corresponding benign cystic neoplasm, often through an intermediate (borderline tumor) step, supporting the morphologic continuum of tumor progression.
  • In contrast, another group of tumors, designated type II, is highly aggressive, evolves rapidly and almost always presents in advanced stage.
  • Type II tumors include conventional high-grade serous carcinoma, undifferentiated carcinoma, and malignant mixed mesodermal tumors (carcinosarcoma).
  • They displayTP53 mutations in over 80% of cases and rarely harbor the mutations that are found in the type I tumors.
  • Recent studies have also provided cogent evidence that what have been traditionally thought to be primary ovarian tumors actually originate in other pelvic organs and involve the ovary secondarily.
  • Thus, it has been proposed that serous tumors arise from the implantation of epithelium (benign or malignant) from the fallopian tube.
  • Endometrioid and clear cell tumors have been associated with endometriosis that is regarded as the precursor of these tumors.
  • Finally, preliminary data suggest that mucinous and transitional (Brenner) tumors arise from transitional-type epithelial nests at the tubal-mesothelial junction by a process of metaplasia.
  • Appreciation of these new concepts will allow for a more rationale approach to screening, treatment, and prevention that potentially can have a significant impact on reducing the mortality of this devastating disease.


86. Lee JC, Bhatt S, Dogra VS: Imaging of the epididymis. Ultrasound Q; 2008 Mar;24(1):3-16

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  • Ultrasonography performed with a high-frequency transducer is the modality of choice for evaluating acute and nonacute scrotal disease.
  • Features of benign and malignant epididymal lesions, including epididymal cysts, spermatoceles and tubular ectasia, sperm granulomas, adenomatoid tumors, leiomyomas, papillary cyst adenomas, lymphoma, and metastases are also presented.

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  • (PMID = 18362528.001).
  • [ISSN] 0894-8771
  • [Journal-full-title] Ultrasound quarterly
  • [ISO-abbreviation] Ultrasound Q
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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87. Serrano Frago P, Medrano Llorente P, Borque Fernando A, Pascual Llorente M, Allue López M: [Consults by scrotum mass: epididymo lesions]. Actas Urol Esp; 2007 Apr;31(4):420-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this review we try to update the knowledge about the tumors of epididymis, describing problems in diagnosis and treatment.
  • We present a case of a 39 years old patient who consults by left testicular mass, before the sonogarphy suspect of tumor was made magnetic resonance imaging , wich aimed towards tumorlike injury.
  • Excision of the injury via inguinal was made and the pathologic diagnosis was of adenomatoid tumor.
  • Owing to the few series that appear in literature, and being the commentaries of these tumors about isolated cases, we expose the characteristics of this illustrated case to value the characteristics in diagnosis and treatment to compare them with other cases.
  • [MeSH-major] Adenomatoid Tumor / diagnosis. Epididymis. Genital Neoplasms, Male / diagnosis. Scrotum

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  • (PMID = 17633931.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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88. Kazakov DV, Hes O, Hora M, Sima R, Michal M: Primary intranodal cellular angiolipoma. Int J Surg Pathol; 2005 Jan;13(1):99-101

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  • Angiolipoma is a distinct, benign soft tissue tumor that most commonly occurs in young males as multiple small, subcutaneous, tender to painful nodules with predilection for the forearms.
  • Lymph nodes are known to be a rare primary site of various tumors usually occurring in other organs.
  • The knowledge of these tumors is important in order not to interpret them as metastatic lesions.
  • The most recognized examples are pigmented nevi, palisading myofibroblastoma, various benign epithelial inclusions, serous cystic tumors of borderline malignancy, and hyperplastic mesothelial inclusions.
  • As we present in this report, angiolipoma is another neoplasm whose primary occurrence in the lymph node should not be misinterpreted as a metastatic tumor or malignant vascular tumor.
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Antigens, CD31 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Lymphatic Metastasis / diagnosis. Male. Metaplasia / pathology

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  • (PMID = 15735863.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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89. Acikalin MF, Tanir HM, Ozalp S, Dundar E, Ciftci E, Ozalp E: Diffuse uterine adenomatoid tumor in a patient with chronic hepatitis C virus infection. Int J Gynecol Cancer; 2009 Feb;19(2):242-4
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  • [Title] Diffuse uterine adenomatoid tumor in a patient with chronic hepatitis C virus infection.
  • Uterine adenomatoid tumors are usually solitary lesions.
  • Adenomatoid tumors diffusely infiltrating the entire myometrium have rarely been reported in the literature.
  • A feature common to half of the reported cases of diffuse uterine adenomatoid tumor was an immunocompromised status of the patient caused by the medications for renal transplantation.
  • In this article, we describe an unusual case of diffuse uterine adenomatoid tumor in a patient with chronic hepatitis C virus infection.
  • Pathological examination showed, in addition to multiple leiomyomas, diffuse uterine adenomatoid tumor.
  • [MeSH-major] Adenomatoid Tumor / immunology. Hepatitis C, Chronic / immunology. Immunocompromised Host. Uterine Neoplasms / immunology

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  • (PMID = 19396001.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Yildirim H, Metintas M, Entok E, Ak G, Ak I, Dundar E, Erginel S: Clinical value of fluorodeoxyglucose-positron emission tomography/computed tomography in differentiation of malignant mesothelioma from asbestos-related benign pleural disease: an observational pilot study. J Thorac Oncol; 2009 Dec;4(12):1480-4
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  • [Title] Clinical value of fluorodeoxyglucose-positron emission tomography/computed tomography in differentiation of malignant mesothelioma from asbestos-related benign pleural disease: an observational pilot study.
  • In this pilot study, we investigate the role of 18F-FDG positron emission tomography/computed tomography (PET/CT) for differentiating asbestos-related benign pleural disease from malignant mesothelioma.
  • MATERIALS AND METHODS: The study population comprised 31 consecutive patients (17 malignant mesotheliomas, nine benign asbestos pleurisies, and five diffuse pleural fibrosis) with a mean age of 61 years between January 2006 and December 2008.
  • ROCs analyses for standardized uptake value (SUV) adjusted to body weight were calculated between benign and malignant pleural diseases.
  • RESULTS: 18F-FDG PET/CT imaging correctly detected the presence of malignancies in 15 of 17 patients with malignant mesothelioma for sensitivity, specificity, and overall accuracy of 88.2%, 92.9%, and 90.3%, respectively.
  • 18F-FDG PET/CT imaging correctly identified 13 of 14 cases of benign pleural disease.
  • The mean SUV values were 6.5 +/- 3.4 for malignant mesothelioma cases and 0.8 +/- 0.6 for benign pleural diseases (p < 0.001).
  • When we compared the two groups of pleural disease, a cut-off value of 2.2 for SUV gave the best accuracy with 94.1%, 100%, 100%, and 93.3% for sensitivity, specificity, positive predictive value, and negative predictive value, respectively.
  • CONCLUSION: Preliminary results of this trial provide evidence that 18F-FDG PET/CT imaging is a highly accurate and reliable noninvasive test to decide for further investigation of differentiating malignant mesothelioma from benign pleural disease.
  • [MeSH-major] Asbestos / adverse effects. Fluorodeoxyglucose F18. Mesothelioma / radionuclide imaging. Pleural Diseases / radionuclide imaging. Pleural Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Radiopharmaceuticals

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  • (PMID = 19875971.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 1332-21-4 / Asbestos
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91. Hong R, Choi DY, Choi SJ, Lim SC: Multicentric infarcted leiomyoadenomatoid tumor: a case report. Int J Clin Exp Pathol; 2009;2(1):99-103

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  • [Title] Multicentric infarcted leiomyoadenomatoid tumor: a case report.
  • Adenomatoid tumor is a benign, usually small lesion that may be found within the wall of fallopian tubes or beneath the uterine serosa near the uterine cornu.
  • It is often accompanied by smooth muscle hypertrophy that may obscure the adenomatoid tumor.
  • We herein report a very unusual case of infarcted leiomyoadenomatoid tumor of the uterus and ovary in a 24-year-old woman who presented with severe lower abdominal pain and masses in the uterus and right ovary.
  • Laparoscopy-assisted transvaginal mass removal was performed under the clinical impression of a uterine leiomyoma and benign ovarian teratoma.
  • On a microscopic examination, prominent fascicles of smooth muscle separated or infiltrated by cuboidal or signet ring-like vacuolated cells, as well as tubular formations lined by flattened mesothelial cells and extensive necrosis were observed in both masses.
  • The microscopic appearance often suggested the possibility of a malignant neoplasm due to irregular pseudoinfiltration with atypical cuboidal cells and the paucity of a typical adenomatoid tumor due to infarction, and the presence of epithelial-appearing cells in the hypertrophic smooth muscle bundles that mimicked an infiltrating carcinoma for a leiomyoma or myometrium.
  • These unemphasized features of leiomyoadenomatoid tumors may potentially lead to more aggressive therapy than warranted if not correctly interpreted, especially for infarcted cases.

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  • [Cites] Int J Gynecol Pathol. 2007 Jan;26(1):16-20 [17197891.001]
  • [Cites] Arch Gynecol Obstet. 2001 Aug;265(3):151-4 [11561745.001]
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  • (PMID = 18830386.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Leiomyoadenomatoid tumor / infarction / ovary / uterus
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92. Scherpereel A, Grigoriu B, Conti M, Gey T, Grégoire M, Copin MC, Devos P, Chahine B, Porte H, Lassalle P: Soluble mesothelin-related peptides in the diagnosis of malignant pleural mesothelioma. Am J Respir Crit Care Med; 2006 May 15;173(10):1155-60
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  • [Title] Soluble mesothelin-related peptides in the diagnosis of malignant pleural mesothelioma.
  • BACKGROUND: Diagnosis of malignant pleural mesothelioma is a challenging issue.
  • Potential markers in mesothelioma diagnosis include soluble mesothelin-related peptides (SMRPs) and osteopontin, but no subsequent validation has been published yet.
  • METHODS: We prospectively evaluated SMRPs in serum and pleural effusion from patients with mesothelioma (n = 74), pleural metastasis of carcinomas (n = 35), or benign pleural lesions associated with asbestos exposure (n = 28), recruited when first suspected for mesothelioma.
  • FINDINGS: Mean serum SMRP level was higher in patients with mesothelioma (2.05 +/- 2.57 nM/L [median +/- interquartile range]) than in patients with metastasis (1.02 +/- 1.79 nM/L) or benign lesions (0.55 +/- 0.59 nM/L).
  • The area under the receiver operating characteristic curve (AUC) for serum SMRP was 0.872 for differentiating mesothelioma and benign lesions, cut-off = 0.93 nM/L (sensitivity = 80%, specificity = 82.6%).
  • The AUC for serum SMRP differentiating metastasis and mesothelioma was 0.693, cut-off = 1.85 nM/L (sensitivity = 58.3%, specificity = 73.3%).
  • SMRP values in pleural fluid were higher than in serum in all groups (mesothelioma: 46.1 +/- 83.2 nM/L; benign lesions: 6.4 +/- 11.1 nM/L; metastasis: 6.36 +/- 21.73 nM/L).
  • The AUC for pleural SMRP-differentiating benign lesions and mesothelioma was 0.831, cut-off = 10.4 nM/L (sensitivity = 76.7%, specificity = 76.2%).
  • The AUC for pleural SMRP-differentiating metastasis and mesothelioma was 0.793.
  • INTERPRETATION: We show that SMRPs may be a promising marker for mesothelioma diagnosis when measured either in serum or pleural fluid.
  • The diagnostic value of SMRPs was similar in both types of samples, but pleural fluid SMRPs may better discriminate mesothelioma from pleural metastasis.
  • [MeSH-major] Asbestosis / pathology. Membrane Glycoproteins / metabolism. Mesothelioma / pathology. Pleural Effusion, Malignant / diagnosis. Pleural Neoplasms / pathology. Sialoglycoproteins / metabolism
  • [MeSH-minor] Aged. Analysis of Variance. Area Under Curve. Biomarkers, Tumor / analysis. Diagnosis, Differential. Disease Progression. Female. GPI-Linked Proteins. Humans. Male. Middle Aged. Neoplasm Staging. Osteopontin. Prognosis. Prospective Studies. Sensitivity and Specificity. Solubility. Survival Analysis

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  • (PMID = 16456138.001).
  • [ISSN] 1073-449X
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 0 / mesothelin; 106441-73-0 / Osteopontin
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93. Garg K, Lee P, Ro JY, Qu Z, Troncoso P, Ayala AG: Adenomatoid tumor of the adrenal gland: a clinicopathologic study of 3 cases. Ann Diagn Pathol; 2005 Feb;9(1):11-5
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  • [Title] Adenomatoid tumor of the adrenal gland: a clinicopathologic study of 3 cases.
  • Adenomatoid tumors are relatively uncommon benign neoplasms of mesothelial origin, usually occurring in the male and female genital tracts.
  • Rare extragenital adenomatoid tumors have been identified in the adrenal glands, heart, mesentery, pleura, and lymph nodes.
  • In the adrenal gland, adenomatoid tumors may pose a diagnostic challenge.
  • Because of its glandular pattern, an adenomatoid tumor may be confused with an adenocarcinoma.
  • We present 3 cases of adrenal adenomatoid tumors, including one with a concurrent large hemorrhagic vascular adrenal cyst.
  • The adenomatoid tumors were unilateral, appeared solid and white, and varied from 1.7 to 4.2 cm in diameter.
  • One patient presented with abdominal pain due to the presence of a concurrent large adrenal cyst.
  • The tumor was an incidental radiological finding in another case and was discovered during the course of a workup for hypertension in the third case.
  • The light microscopic appearances were consistent with those of typical adenomatoid tumors.
  • Immunohistochemical stains for calretinin and cytokeratin 5/6 were positive, confirming the tumors' mesothelial origin.
  • In our experience, the key to the diagnosis of this rare benign tumor is to consider adenomatoid tumor in the differential diagnosis of any glandular tumor occurring in the adrenal gland.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adult. Biomarkers, Tumor / metabolism. Calbindin 2. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Cysts / complications. Cysts / metabolism. Cysts / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. S100 Calcium Binding Protein G / metabolism. Treatment Outcome

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  • (PMID = 15692945.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 68238-35-7 / Keratins
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94. Zendehrokh N, Rehnberg J, Dejmek A: Comparison of NCL-hTERT antibody reactivity and telomere repeat amplification protocol in situ in effusions. Acta Cytol; 2007 Nov-Dec;51(6):886-92
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  • RESULTS: Thirty-four effusions from patients with verified malignant disease contained cytologically malignant cells.
  • Twenty effusions, all containing mesothelial cells, came from patients with benign conditions.
  • In 2 fluids atypical, hyperplastic mesothelial cells were both TRAP in situ and hTERT positive.
  • Thus the results of TRAP in situ and hTERT immunohistochemistry disagreed in 1 of 34 (3%) malignant and 12 of 20 (60%) benign cases.
  • The specificity of the applied hTERT antibody was significantly lower, due to hTERT reactivity in mesothelial cells.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Nucleus / enzymology. Cell Nucleus / genetics. DNA, Neoplasm / analysis. Female. Humans. Neoplasms, Mesothelial / diagnosis. Neoplasms, Mesothelial / enzymology. Phosphoproteins / immunology. Phosphoproteins / metabolism. RNA-Binding Proteins / immunology. RNA-Binding Proteins / metabolism. Repetitive Sequences, Nucleic Acid / genetics. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 18077981.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / nucleolin; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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95. Erra S, Pastormerlo M, Gregori G, Costamagna D, Pavesi M: A case of leiomyoadenomatoid tumour of uterine serosa: speculations about differential diagnosis. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of leiomyoadenomatoid tumour of uterine serosa: speculations about differential diagnosis.
  • Adenomatoid tumour is a benign rare lesion of the female genital tract, localised in the wall of fallopian tubes or beneath the uterine serosa.
  • It is often accompanied by smooth muscle proliferation, obscuring the presence of adenomatoid tumour, resulting in misdiagnosis of cellular leiomyoma.Here, a case of uterine serosal adenomatoid tumour associated with multiple leiomyomas and pelvic endometriosis in a 44-year-old woman who underwent surgical removal for uterine bleeding and abdominal pain is presented.

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  • [Cites] J Pathol Bacteriol. 1953 Oct;66(2):417-32 [13118448.001]
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  • (PMID = 21686986.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029656
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96. Monappa V, Rao AC, Krishnanand G, Mathew M, Garg S: Adenomatoid tumor of tunica albuginea mimicking seminoma on fine needle aspiration cytology: a case report. Acta Cytol; 2009 May-Jun;53(3):349-52
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  • [Title] Adenomatoid tumor of tunica albuginea mimicking seminoma on fine needle aspiration cytology: a case report.
  • BACKGROUND: Adenomatoid tumor is one of the most common primary neoplasms of the paratesticular area.
  • Review of the literature showed very few reports on the cytologic features of adenomatoid tumor.
  • We report the cytologic features of a case of adenomatoid tumor arising from testicular tunica albuginea.
  • Histopathologic examination confirmed the diagnosis as adenomatoid tumor of tunica albuginea.
  • CONCLUSION: FNAC of an adenomatoid tumor poses a diagnostic challenge when the tumor arises from sites other than the epididymis because they can be mistaken for intratesticular tumors.
  • It is thus important to consider this tumor in the differential diagnosis of scrotal swellings.
  • [MeSH-major] Adenomatoid Tumor / pathology. Seminoma / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adult. Biopsy, Fine-Needle. Cystadenoma, Papillary / diagnosis. Diagnosis, Differential. Epithelium / pathology. Humans. Hyperplasia / diagnosis. Male. Mesothelioma / diagnosis. Orchiectomy

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  • (PMID = 19534283.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Ruiz Liso JM, Ruiz Garcia J, Pardo López ML, Vaillo Vinagre A, Gutiérrez Martín A, Bermúdez Villaverde R: [Epididymis trombosed hemangioma in old patient. Presentation of 1 case with conceptual review and of the literature]. Actas Urol Esp; 2008 May;32(5):533-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Hemangioma epididimario trombosado en paciente mayor. Presentación de 1 caso con revisión conceptual y de la literatura.
  • INTRODUCTION: Though theoretically in the paratesticular region one can develop any type of benign tumour of soft tissues, they are the lipomas, leiomyomas and adenomatoid tumours the most usual whereas the hemangiomas are less common.
  • We contribute a new case of epididymis intrascrotal hemangioma (HI), valuing the bibliography that allows us to know the incidence and clinic-pathologic characteristics of these tumours.
  • MATERIAL AND METHOD: A 74-year-old patient includes for study with right scrotal tumour, who is practised orchiectomy.
  • Of equal form there is realized a bibliographical examination of this type of tumours across Medline and of not index-linked search with conceptual review and of the literature.
  • Your hystopathologic diagnosis does not present problems, whereas the clinical one and ultrasonographic study, reaches the whole spectrum of tumours, benign and malignant of soft tissues.
  • CONCLUSIONS: The scrotal tumours are necessary a preoperatory clinical and sonographic study completely, in spite of the fact that they are diagnosed the majority after your surgical removal.
  • The complex system of the tissues on the zone paratesticular implies that the differential enclosed diagnosis does not allow to differentiate, malignant tumours of benign.

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  • (PMID = 18605005.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 92
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98. Varkarakis IM, Mufarrij P, Studeman KD, Jarrett TW: Adenomatoid of the adrenal gland. Urology; 2005 Jan;65(1):175
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  • [Title] Adenomatoid of the adrenal gland.
  • Adenomatoid tumors are common in the genital tract but rare in the adrenal gland.
  • These tumors can be difficult to diagnose when present in extragenital sites.
  • This type of adrenal tumor lacks specific radiographic features and can be confused preoperatively with more common adrenal gland tumors.
  • We present the case of a 54-year-old man with an incidental right adrenal mass with calcified components and elevated urinary levels of homovanillic acid that was found to be an adenomatoid tumor of the adrenal gland.
  • [MeSH-major] Adenomatoid Tumor / radiography. Adrenal Gland Neoplasms / radiography. Calcinosis / radiography
  • [MeSH-minor] Biomarkers, Tumor / analysis. Calbindin 2. Homovanillic Acid / urine. Humans. Incidental Findings. Kidney Calculi / complications. Kidney Calculi / radiography. Male. Middle Aged. Neoplasm Proteins / analysis. S100 Calcium Binding Protein G / analysis

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  • (PMID = 15667895.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calbindin 2; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; X77S6GMS36 / Homovanillic Acid
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99. Shen J, Pinkus GS, Deshpande V, Cibas ES: Usefulness of EMA, GLUT-1, and XIAP for the cytologic diagnosis of malignant mesothelioma in body cavity fluids. Am J Clin Pathol; 2009 Apr;131(4):516-23
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  • [Title] Usefulness of EMA, GLUT-1, and XIAP for the cytologic diagnosis of malignant mesothelioma in body cavity fluids.
  • We compared the effectiveness of epithelial membrane antigen (EMA) with 2 newly described markers, X-linked inhibitor of apoptosis protein (XIAP) and an isoform of glucose transporter (GLUT-1), in the distinction between malignant mesothelioma (MM) and benign effusion (BE) in body cavity fluids.
  • [MeSH-major] Glucose Transporter Type 1 / biosynthesis. Mesothelioma / diagnosis. Mucin-1 / biosynthesis. Pleural Effusion, Malignant / diagnosis. Pleural Neoplasms / diagnosis. X-Linked Inhibitor of Apoptosis Protein / biosynthesis
  • [MeSH-minor] Aged. Aged, 80 and over. Area Under Curve. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 19289587.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / Mucin-1; 0 / X-Linked Inhibitor of Apoptosis Protein; 0 / XIAP protein, human
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100. Garriga V, Serrano A, Marin A, Medrano S, Roson N, Pruna X: US of the tunica vaginalis testis: anatomic relationships and pathologic conditions. Radiographics; 2009 Nov;29(7):2017-32
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  • Most lesions originate from or depend on the tunica vaginalis, a mesothelium-lined sac with a visceral layer and a parietal layer.
  • Lesions of mesothelial origin, such as adenomatoid tumor, tunica cyst, and mesothelioma, may involve the tunica vaginalis.
  • Entrapped mesenchymal cells can lead to lipoma, leiomyoma, or sarcoma, although these tumors are uncommon in the tunica vaginalis.
  • US is not useful for differentiating between benign and malignant tumors; however, some characteristic findings may help in planning the best surgical approach.

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  • (PMID = 19926760.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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