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1. Sempau L, Alonso-Alonso T, González-Morán A, Prada C, Lamoca-Martín M, Rodríguez-Prieto MA: [A new case of nevus oligemicus]. Dermatol Online J; 2010;16(8):16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A new case of nevus oligemicus].
  • [Transliterated title] Un nuevo caso de nevus oligemicus.
  • Nevus oligemicus is a rare lesion characterized by selective vasoconstriction of the deep dermal vascular plexus compared with the superficial one.
  • It has been suggested that it may be caused by increased sympathetic tone in the deep dermal vascular plexus or an abnormality of hormone receptors, which is why it is considered a functional nevus.
  • Clinically, it presents as an asymptomatic, fixed, livid erythematous macule with a striking decrease in local temperature compared with surrounding healthy skin.
  • Measurement of the surface temperature of the patch revealed a decrease of up to 2.5 degrees C with respect to surrounding skin.
  • The fixed nature of the lesions, consistent histopathology, and the finding of localized hypothermia allowed the diagnosis of nevus oligemicus.
  • Our case is the eleventh case of nevus oligemicus reported in the literature.
  • [MeSH-major] Nevus / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20804693.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Sulfonamides; 56211-40-6 / torsemide; E7199S1YWR / Lisinopril
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2. Hammer H, Tóth-Molnár E, Oláh J, Dobozy A: [Connection between uveal melanoma and dysplastic naevus syndrome]. Magy Onkol; 2005;49(1):15-8
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  • [Title] [Connection between uveal melanoma and dysplastic naevus syndrome].
  • [Transliterated title] Az uvealis melanoma és a dysplasticus naevus-syndroma kapcsolata.
  • The dysplastic naevus syndrome increases the risk of cutaneous (RR: 4.36; CI: 1.84-10.36) as well as uveal melanoma (RR: 4.22; CI: 1.81-9.84).
  • A significantly higher occurrence rate of conjunctival naevi (3.2% vs. 0%; p=0.029), choroidal naevi (5.2% vs. 0.7%; p=0.023) and iris freckles (17.1% vs. 5.6%; p=0.002) could be detected in the dysplastic naevus syndrome patients compared to subjects in the control group.
  • The presence of cutaneous dysplastic naevi in uveal melanoma patients increases the risk of the prognostically worse--epitheloid or mixed--forms of uveal melanoma (RR: 5.97%; CI: 1.61-22.14), compared to patients without cutaneous atypical naevi.
  • [MeSH-major] DNA, Neoplasm / analysis. Dysplastic Nevus Syndrome / genetics. Melanoma / genetics. Skin Neoplasms / genetics. Uveal Neoplasms / genetics

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  • (PMID = 15902328.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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3. Gallego Peinado M, de Arcocha Torres M, López Casado MA, Custosio Rebollo Aguirre A, Santiago Chinchilla A, Llamas Elvira JM: [Usefulness of labelled red-cell scintigraphy in Blue Rubber-Bleb Nevus syndrome]. Rev Esp Med Nucl; 2009 Jan-Feb;28(1):18-21
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  • [Title] [Usefulness of labelled red-cell scintigraphy in Blue Rubber-Bleb Nevus syndrome].
  • [Transliterated title] Utilidad de la gammagrafía con hematíes marcados en el síndrome de Blue Rubber Bleb Nevus.
  • Blue Rubber Bleb Nevus syndrome is a rare disorder characterized by distinctive cutaneous and gastrointestinal venous malformations that usually cause episodes of occult gastrointestinal haemorrhage and iron deficiency anaemia.
  • To evaluate the presence of gastrointestinal bleeding secondary to intestinal angiomatosis, we decided to perform 99mTc-labelled red blood cell scintigraphy, which confirmed cutaneous venous malformations and also showed gastrointestinal vascular lesions that suggested the diagnosis of Blue Rubber Bleb Nevus Syndrome.
  • [MeSH-major] Abnormalities, Multiple / radionuclide imaging. Angiomatosis / radionuclide imaging. Erythrocytes. Intestinal Diseases / radionuclide imaging. Nevus, Blue / radionuclide imaging. Radiopharmaceuticals. Skin Neoplasms / radionuclide imaging. Technetium

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  • (PMID = 19232173.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 7440-26-8 / Technetium
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4. Titus-Ernstoff L, Perry AE, Spencer SK, Gibson JJ, Cole BF, Ernstoff MS: Pigmentary characteristics and moles in relation to melanoma risk. Int J Cancer; 2005 Aug 10;116(1):144-9
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  • [Title] Pigmentary characteristics and moles in relation to melanoma risk.
  • Although benign and atypical moles are considered key melanoma risk factors, previous studies of their influence were small and/or institution-based.
  • Individuals of ages 20-69 with an incident diagnosis of first primary cutaneous melanoma were ascertained through the New Hampshire State Cancer Registry.
  • Host characteristics, including mole counts, were evaluated using logistic regression analyses.
  • Our results showed that pigmentary factors, including eye color (OR = 1.57 for blue eyes compared to brown), hair color (OR = 1.85 for blonde/red hair color compared to brown/black), freckles before age 15 (OR = 2.39 for freckles present compared to absent) and sun sensitivity (OR = 2.25 for peeling sunburn followed by no tan or a light tan and 2.42 for sunburn followed by tan compared to tanning immediately), were related to melanoma risk; these associations held after adjustment for sun-related factors and for moles.
  • In analyses confined to skin examination participants, the covariate-adjusted effects of benign and atypical moles were moderately strong.
  • Compared to 0-4 benign moles, risk increased steadily for 5-14 moles (OR = 1.71), 15-24 moles (OR = 3.55) and >or= 25 moles (OR = 4.33).
  • Risk also increased with the number of atypical moles; compared to none, the ORs for having 1, 2-3, or >or= 4 atypical moles were 2.08, 1.84 and 3.80, respectively.
  • Although risk was highest for those with multiple benign and atypical moles, the interaction was not of statistical significance.
  • Our findings, arising from the first population- and incidence-based study to evaluate atypical moles in relation to melanoma risk, confirm the importance of host susceptibility, represented by pigmentary factors and the tendency to develop benign or atypical moles, in the etiology of this disease.
  • [MeSH-major] Melanoma / etiology. Nevus / epidemiology. Skin Neoplasms / etiology. Skin Pigmentation

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15761869.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA66032
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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5. Ngo Duc H, van Trommel NE, Sweep FC, Massuger LF, Thomas CM: Clinical utility of hyperglycosylated hCG in serum taken before hydatidiform mole evacuation to predict persistent trophoblastic disease. Int J Biol Markers; 2006 Jan - Mar;21(1):45-49

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  • [Title] Clinical utility of hyperglycosylated hCG in serum taken before hydatidiform mole evacuation to predict persistent trophoblastic disease.
  • OBJECTIVE: Human chorionic gonadotropin (hCG) is widely used in the management of hydatidiform mole and persistent rophoblastic disease (PTD).
  • DESIGN: A retrospective study based on blood specimens collected in the Dutch Central Registry for Hydatidiform Moles.
  • The study group comprised 97 patients with hydatidiform moles who did not develop PTD after mole evacuation and 33 patients who did develop PTD.
  • METHODS: Serum samples from 130 patients with hydatidiform mole with or without PTD were assayed using specific (radio) immunoassays for free hCG , total hCG, and ITA.

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  • (PMID = 28207093.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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6. Yap FB: Nevus lipomatosus superficialis. Singapore Med J; 2009 May;50(5):e161-2
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  • [Title] Nevus lipomatosus superficialis.
  • Nevus lipomatosus superficialis is a rare benign skin malformation characterised by ectopic adipocytes in the upper dermis.
  • A case of the classical type with multiple soft, non-tender, pedunculated, cerebriform, skin-coloured papules and nodules over the right lower back is presented in a 21-year-old Malay woman.
  • [MeSH-minor] Adipocytes / pathology. Adult. Female. Humans. Nevus, Pigmented / diagnosis. Nevus, Pigmented / pathology. Nevus, Pigmented / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 19495497.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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7. Pinheiro AM, Pereira GA, Amorin AG, Varella TC, Friedman H: Spitz nevus: a case report and the use of dermoscopy. An Bras Dermatol; 2010 Jul-Aug;85(4):555-7
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  • [Title] Spitz nevus: a case report and the use of dermoscopy.
  • The Spitz nevus is a benign melanocytic lesion with clinical and histopathological features similar to those of melanoma.
  • In Spitz nevus, the most common dermoscopic finding is a starburst-like pattern, followed by globular and atypical patterns.
  • [MeSH-major] Dermoscopy. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 20944920.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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8. Kovich O, Hale EK: Nevus sebaceus. Dermatol Online J; 2005;11(4):16
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  • [Title] Nevus sebaceus.
  • A 35-year-old woman presented with cosmetically disturbing facial plaques, which had been present since birth and were consistent with nevus sebaceus on histopathologic examination.
  • Nevus sebaceus is a congenital, hairless plaque, which is found most commonly on the scalp and face and typically becomes thicker and more verrucous in appearance as the patient enters adulthood.
  • There is an association with benign and malignant neoplasms.
  • [MeSH-major] Facial Neoplasms / pathology. Head and Neck Neoplasms / pathology. Nevus / pathology. Scalp. Skin Neoplasms / pathology


9. Menzies SW: Cutaneous melanoma: making a clinical diagnosis, present and future. Dermatol Ther; 2006 Jan-Feb;19(1):32-9
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  • [Title] Cutaneous melanoma: making a clinical diagnosis, present and future.
  • The minimum requirement for the general dermatologist for clinically assessing pigmented skin lesions is dermoscopy.
  • In expert hands, this technique has been shown to improve both the sensitivity and specificity for the diagnosis of melanoma.
  • This is also reflected by lower benign melanoma excision ratios and decreased excision rates.
  • Evidence is mounting for the routine use of total body skin photography for patients with a very high risk of developing cutaneous melanoma.
  • Both long-term (12 months) and short-term (3 months) digital dermoscopy monitoring has been shown to allow the detection of dermoscopically featureless melanoma and is central for the clinical assessment of melanocytic lesions at the Sydney Melanoma Diagnostic Center.
  • The use of automated instruments for the diagnosis of cutaneous melanoma is still in an experimental phase, and its utility is dependent on the evidence that such instruments give a clinically useful expert second opinion.
  • [MeSH-major] Dermatology / trends. Early Diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16405568.001).
  • [ISSN] 1396-0296
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 48
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10. Baykal C, Buyukbabani N, Yazganoglu KD, Saglik E: [Tumors associated with nevus sebaceous]. J Dtsch Dermatol Ges; 2006 Jan;4(1):28-31
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  • [Title] [Tumors associated with nevus sebaceous].
  • [Transliterated title] Mit Naevus sebaceus assoziierte Tumoren.
  • BACKGROUND: Nevus sebaceus (NS) is a congenital hamartomatous lesion, usually involving the scalp or the face.
  • Various benign and malignant neoplasms can develop in association with NS, the most common being trichoblastoma, syringocystadenoma papilliferum, viral warts and basal cell carcinoma (BCC).
  • Trichoblastoma was observed in 3 cases and was the most common benign tumor in our series.
  • CONCLUSION: Clinical features are not sufficient enough to make an exact diagnosis of benign or malignant secondary tumors.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Second Primary / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Facial Neoplasms / diagnosis. Facial Neoplasms / pathology. Female. Humans. Male. Middle Aged. Scalp / pathology. Skin / pathology

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  • (PMID = 16503928.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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11. Mallo-García S, Coto-Segura P, Galache-Osuna C, Santos-Juanes-Jiménez J: [Six cases of nevus oligemicus]. Actas Dermosifiliogr; 2008 May;99(4):301-4
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  • [Title] [Six cases of nevus oligemicus].
  • [Transliterated title] Nevus oligemicus. Aportación de seis casos.
  • Hamartoma or nevus oligemicus is an uncommon lesion that is characterized by selective vasoconstriction of the deep dermal vascular plexus with respect to the superficial one and whose cause has not been clearly established.
  • This selective vasoconstriction gives rise to fixed, acquired, and asymptomatic lesions in the form of livid, erythematous macules that are typically cold to touch compared with surrounding skin.
  • We report the cases of 6 young men with lesions clinically compatible with nevus oligemicus on the abdomen and flanks.
  • Measurement of the surface temperature of the lesion revealed a decrease of up to 2.5 degrees C with respect to healthy surrounding skin and allowed a definitive diagnosis to be made.
  • In our opinion, nevus oligemicus is an underdiagnosed lesion that is much more common than has been reported in the literature.
  • [MeSH-major] Hamartoma / diagnosis. Skin Diseases / diagnosis

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  • (PMID = 18394407.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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12. Salava A, Ranki A, Saksela O: [Dysplastic melanocytic nevus]. Duodecim; 2010;126(21):2492-501
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  • [Title] [Dysplastic melanocytic nevus].
  • The dysplastic melanocytic nevus remains an issue of controversy despite extensive investigations.
  • On clinical grounds the term atypical melanocytic nevus should be used, while dysplastic melanocytic nevus describes histological characteristics.
  • The association with melanoma is complex.
  • With the clinical picture, dermatoscopy and molecular biological or genetic examinations one can often not distinguish a histological dysplastic nevus from a melanoma.
  • In patients with large amounts of melanocytic nevi it is important to assess the total melanoma risk, the need for patient surveillance and motivate the patient for self-examination.
  • In high-risk patients the amount of benign melanocytic nevi is increased and many clinically atypical and microscopically dysplastic nevi can be found.
  • Because of the rising incidence of melanoma and the lack of therapeutic options in disseminated disease, the surveillance of high risk patients, the early detection of melanoma and excision play a key role in patient management.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 21171474.001).
  • [ISSN] 0012-7183
  • [Journal-full-title] Duodecim; lääketieteellinen aikakauskirja
  • [ISO-abbreviation] Duodecim
  • [Language] fin
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Finland
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13. Livory M, Descamps V, Pelletier F, Maubec E, Faivre B, Marinho E, Humbert P, Crickx B, Aubin F: [Melanoma in invisible naevus spilus]. Ann Dermatol Venereol; 2008 Jan;135(1):48-52
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  • [Title] [Melanoma in invisible naevus spilus].
  • [Transliterated title] Mélanome développé sur naevus spilus inapparent.
  • BACKGROUND: Diagnosis of naevus lesions may be complex where they contain little or no pigmentation.
  • Naevus spilus (or naevus on naevus) is, generally, readily identified by the difference in pigmentation between overlying and underlying naevi and healthy skin.
  • Malignant transformation of naevus spilus is rare.
  • We report two cases of melanoma in which surgical procedures revealed underlying melanocyte lesions, diagnosed at histology but undetectable on clinical examination.
  • PATIENTS AND METHODS: Two patients were operated for melanoma in which surgery, at a site remote from the melanoma, suggested incomplete relapse despite the fact that previous clinical examination had indicated healthy skin.
  • A diagnosis was made of melanoma in invisible naevus spilus.
  • DISCUSSION: Diagnosis of melanoma in invisible naevus spilus may be suspected where several naevi are found together in a specific area.
  • [MeSH-major] Melanoma / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 18342074.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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14. Baandrup L, Haedersdal M: [Organoid nevus (nevus sebaceus) dominated by the apocrine glands]. Ugeskr Laeger; 2005 Aug 8;167(32):2900-1
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  • [Title] [Organoid nevus (nevus sebaceus) dominated by the apocrine glands].
  • [Transliterated title] Organoidt naevus (naevus sebaceus) med apokrin dominans.
  • We report a case of congenital organoid nevus with an excessive number of apocrine glands.
  • The lesion was benign and treatment was therefore conservative.
  • [MeSH-major] Apocrine Glands / pathology. Nevus / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16109197.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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15. Moreno-Ramirez D, Ferrandiz L, Rios-Martin JJ, Camacho FM: Dysplastic pointillist nevus. Arch Dermatol; 2005 Jun;141(6):763-4
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  • [Title] Dysplastic pointillist nevus.
  • BACKGROUND: Three cases of pointillist nevus, which is a distinctive clinical type of benign melanocytic nevus with variegated pigment, have been described in the literature to date.
  • OBSERVATIONS: A 24-year-old man presented with an acquired melanocytic lesion composed of multiple tiny pigmented dots.
  • Dermoscopy revealed multiple brown globules on a reddish skin-colored background, and histologic examination demonstrated architectural disorder with cytologic atypia.
  • Conclusion To the best of our knowledge, we report a case of dysplastic pointillist nevus.
  • [MeSH-major] Dysplastic Nevus Syndrome / pathology. Dysplastic Nevus Syndrome / physiopathology

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  • (PMID = 15967924.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Ferrara G, Brasiello M, Annese P, Francione S, Giorgio CM, Moscarella E, Zalaudek I, Argenziano G: Desmoplastic nevus: clinicopathologic keynotes. Am J Dermatopathol; 2009 Oct;31(7):718-22
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  • [Title] Desmoplastic nevus: clinicopathologic keynotes.
  • We describe 3 cases of desmoplastic nevus with special emphasis on some repetitive dermoscopic and histopathologic features, which-if confirmed on larger series-could allow to identify desmoplastic nevus as a specific clinicopathologic entity within the spectrum of acquired melanocytic nevi.
  • [MeSH-major] Nevus / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermoscopy. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / pathology. Humans. Immunohistochemistry. Melanoma / pathology. Middle Aged. Nevus, Epithelioid and Spindle Cell / pathology

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  • (PMID = 19684509.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Garrido Abad P, Jiménez Gálvez M, Fernández Arjona M, Herranz Fernández LM, Bocardo Fajardo G, Herrero Torres L, Pereira Sanz I: [Blue prostatic nevus. Case report]. Arch Esp Urol; 2007 Jun;60(5):593-5
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  • [Title] [Blue prostatic nevus. Case report].
  • [Transliterated title] Nevus azul prostático. Aportación de un nuevo caso.
  • METHODS/RESULTS: 66-year-old patient with elevated serum PSA with the diagnosis of prostatic blue nevus after biopsy.
  • They are benign lesions that must not be confused with other similar more aggressive lesions.
  • [MeSH-major] Nevus, Blue / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 17718219.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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18. Kayali F, Janjua MA, Laber DA, Miller DM, Day JM, Kloecker GH: Phase II trial of second-line erlotinib and digoxin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol; 2009 May 20;27(15_suppl):e19077

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  • This suggests that inhibition of the Na/K pump results in cellular sensitization of malignant, but not benign cells to induction of apoptosis.
  • At ASCO 2007 our group presented a phase II study showing encouraging results by adding digoxin to bio-chemotherapy for melanoma.

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  • (PMID = 27962216.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Gundrum JD, Go R, Kwong R: Cancer in the oldest old population in the United States: Current statistics and projections. J Clin Oncol; 2009 May 20;27(15_suppl):9553

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  • We included patients who had a previous cancer before age 85, but excluded benign tumors, myeloproliferative, and myelodysplastic neoplasms.
  • The 10 leading cancers by incidence (both sexes and decreasing order) are colorectal (388.9), lung (287.7), breast (250), prostate (211.5), urinary bladder (162.5), non-Hodgkin lymphoma (110.9), leukemia (85.1), melanoma (65), renal (46.4), and uterine (40.2).
  • The incidences of melanoma, non-Hodgkin lymphoma, renal, and lung cancers are increasing, while those of leukemia, prostate, breast, and colorectal cancers are decreasing.
  • Cancer specific survival (CSS) has been increasing continuously since 1973 for melanoma, non-Hodgkin lymphoma, breast, colorectal, prostate, and urinary bladder cancers but decreasing in recent years for colorectal, breast, prostate, and uterine cancers.

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  • (PMID = 27963637.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Pariyar J: Gestational trophoblastic disease in Nepalese women managed in B. P. Koirala Memorial Cancer Hospital. J Clin Oncol; 2009 May 20;27(15_suppl):e16570

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  • There were 17 cases (37.8%) of hydatidiform mole, 6 were invasive mole (13.35%), 4 of persistent gestational trophoblastic tumour (8.8%) and 22 patients (48.8%) of choriocarcinoma.
  • Among the 45 cases 6 (13.3%) were treated with suction evacuation only; 9 (20%) underwent hysterectomy for uterine perforation, excessive hemorrhage and invasive mole.

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  • (PMID = 27961513.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Frankenthaler A, Lee M, Seery V, Renzi S, Kinnaman M, Liu V, Friedman E, Atkins MB, Cutaneous Oncology Program: Impact of concomitant immunosuppression on the presentation and prognosis of patients with melanoma. J Clin Oncol; 2009 May 20;27(15_suppl):9070

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  • [Title] Impact of concomitant immunosuppression on the presentation and prognosis of patients with melanoma.
  • : 9070 Background: Melanoma has been reported to be susceptible to immune control.
  • METHODS: We examined the Beth Israel Deaconess Medical Center Cutaneous Oncology Program database for pts with immune suppression at the time of melanoma diagnosis.
  • RESULTS: 19 pts were identified with melanoma and concomitant immune suppression in a database of 1820 melanoma pts.
  • Melanoma stages at diagnosis were in situ 1, IB 7, IIA 1, IIB 1, IIIB 3, IIIC 5, and IV 1.
  • In addition, more cases appeared to have an amelanotic primary (21% vs. 5.4%) or an atypical mole syndrome (21% vs 10.2%).
  • CONCLUSIONS: Compared to the general melanoma population, pts with concomitant immune suppression appear more likely to be female, have an amelanotic primary or atypical mole syndrome and more advanced disease at presentation.
  • Thus, diagnosis and treatment of a primary melanoma at an early stage appears especially important in an immunosuppressed population.

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  • (PMID = 27962173.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Bonanno A, Esmaeli B, Nelson DV, Fingeret M, Weber RS: Social interaction and stigmatization of cancer patients with orbitofacial disfigurement. J Clin Oncol; 2009 May 20;27(15_suppl):e20659

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  • Cancer diagnoses included lacrimal gland adenoid cystic ca. (n=3), conjunctival SCCA(n=3), and 1 each of conjunctival melanoma, eyelid sebaceous gland ca., lacrimal sac transitional cell ca., orbital adenoca., orbital neuroendocrine ca., and eyelid basal cell ca.
  • In large groups, actions toward patients characterized by "benign neglect" (n=3) - kind indifference toward patients - generate non-stigmatizing outcomes.
  • Sympathy creates positive outcomes, while interaction characterized by benign neglect generates varying patterns.

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  • (PMID = 27961618.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. López Gutiérrez JC, García Palacios M, Díaz M, Soto C, Ros Z: [Indication for early excision of the giant congenital nevus]. Cir Pediatr; 2010 Jul;23(3):165-9
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  • [Title] [Indication for early excision of the giant congenital nevus].
  • [Transliterated title] Indicación para la extirpación precoz de los nevus congénitos gigantes.
  • INTRODUCTION: Most of specialists involved in giant congenital nevi (GCN) care, agree that the risk of melanoma is probably not significant enough to warrant the prophylactic removal of all those lesions.
  • All nevus in the scalp between 3 and 5 cms were removed with a primary closure in order to avoid future need of scalp expansion.
  • CONCLUSIONS: Despite the lack of international consensus regarding the appropriate timing for large or giant congenital nevi excision, a selection of patients and their families can benefit from early surgical removal.
  • [MeSH-major] Nevus / congenital. Nevus / surgery. Skin Neoplasms / congenital. Skin Neoplasms / surgery

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  • (PMID = 23155663.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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24. Abecassis S, Spatz A, Cazeneuve C, Martin-Villepou A, Clerici T, Lacour JP, Avril MF: [Melanoma within naevus spilus: 5 cases]. Ann Dermatol Venereol; 2006 Apr;133(4):323-8
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  • [Title] [Melanoma within naevus spilus: 5 cases].
  • [Transliterated title] Mélanome sur naevus spilus: 5 observations.
  • BACKGROUND: Nevus spilus is defined as café-au-lait macules with dark maculopapular speckles.
  • Histologically, it has the aspect of lentigo associated with nevocellular nevus.
  • There are 3 types of nevus spilus: small or medium-sized (<20 cm), giant and zosteriform.
  • Malignant transformation of nevus spilus is rare.
  • PATIENTS AND METHODS: We analyzed the cases of 5 patients presenting melanoma within nevus spilus as well as 20 published cases.
  • The evaluation criteria were: for nevus spilus: size, type, topography, age of onset and presence of dysplastic nevi within the nevus spilus; for melanoma: clinical aspect, histological type, thickness, level and age at diagnosis.
  • The presence of other risk factors for melanoma was noted.
  • RESULTS: The 14 women and 11 men had a mean age of 49 years at melanoma diagnosis.
  • Type of nevus spilus was: small or medium-sized (15 cases), zosteriform (6 cases) and giant (4 cases).
  • Only 3 nevi spili were<4 cm in diameter.
  • Nevus spilus was present since birth (11 cases), childhood (7 cases), after the age of 20 years (3 cases) and was unspecified in 4 cases.
  • Three of our five patients had other risk factors for melanoma.
  • Two patients were presenting 2 melanomas within nevus spilus.
  • The histological type of melanoma was not specified in 8 cases but SSM was the most common type (13 cases).
  • CONCLUSION: The following criteria appeared to be associated with risk of developing melanoma in nevus spilus patients: nevus spilus present since birth, nevus spilus over 4 cm in diameter, and giant or zosteriform nevus spilus.
  • Development of melanoma within nevus spilus is a rare event.
  • Consequently, guidelines for follow-up of nevus spilus cannot be defined.
  • [MeSH-major] Melanoma / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 16733445.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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25. Anzinger M, Gospos J, Pitzl H, Koletzko S, Heldwein W, Schmitt W: [Blue rubber-bleb nevus syndrome and therapeutic double balloon enteroscopy]. Z Gastroenterol; 2006 Nov;44(11):1141-4
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  • [Title] [Blue rubber-bleb nevus syndrome and therapeutic double balloon enteroscopy].
  • [Transliterated title] Blue-Rubber-bleb-Naevus-Syndrom und therapeutische Doppel-Ballon-Enteroskopie.
  • At birth a blue rubber-bleb nevus syndrome was diagnosed, with blue angiomatous lesions preferring her skin and digestive tract.
  • [MeSH-major] Catheterization / methods. Endoscopy, Gastrointestinal / methods. Gastrointestinal Neoplasms / surgery. Hemangioma / surgery. Laser Therapy / methods. Nevus, Blue / surgery. Skin Neoplasms / surgery

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  • (PMID = 17115355.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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26. Gyl F, Anna-Adrien C, Oanţă A, Irimie M, Edit FJ: [Kissing nevus, a rare form of palpebral nevus--case report]. Oftalmologia; 2008;52(2):89-91
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  • [Title] [Kissing nevus, a rare form of palpebral nevus--case report].
  • [Transliterated title] Kissing naevus (divided naevus) o formă rară de nev nevocelular situat pe pleoape--prezentare de caz.
  • Kissing naevus is a rare form of congenital nevocellular naevus.
  • One of them was 9 years old and had an asymptomatic homogeneously pigmented round-oval naevus on the right eye and two girls (12 and 20 years old) who had the same kind of naevus of different sizes on the left eye, symmetrically situated on the two eyelids.
  • The lower part of the naevus were bigger than the upper part in all the three cases.
  • Histological they are compound or dermal nevus As treatment, ones recommend early excision, others contraindicates any surgical interventions.
  • [MeSH-major] Eyelid Neoplasms / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 19065922.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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27. Zalaudek I, Zanchini R, Petrillo G, Ruocco E, Soyer HP, Argenziano G: Dermoscopy of an acral congenital melanocytic nevus. Pediatr Dermatol; 2005 May-Jun;22(3):188-91
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  • [Title] Dermoscopy of an acral congenital melanocytic nevus.
  • Congenital melanocytic nevi carry a risk for malignant transformation into melanoma, therefore early detection of suspicious features is crucial to reduce mortality rates.
  • Dermoscopy improves the early detection of melanoma while reducing the number of unnecessary excisions of benign pigmented skin lesions.
  • Dermoscopically, congenital melanocytic nevi are often characterized by the presence of a cobblestone pattern, but to date, little is known about the dermoscopic features of acral congenital melanocytic nevi.
  • We report an acral congenital melanocytic nevus typified by the presence of three different dermoscopic patterns that are commonly seen in acquired melanocytic nevi of palms and soles.
  • [MeSH-major] Dermoscopy. Melanoma / congenital. Nevus, Pigmented / congenital. Skin Neoplasms / congenital

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  • (PMID = 15916562.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Bennani-Lahlou M, Mateus C, Escudier B, Massard C, Soria JC, Spatz A, Robert C: [Eruptive nevi associated with sorafenib treatment]. Ann Dermatol Venereol; 2008 Oct;135(10):672-4
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  • [Title] [Eruptive nevi associated with sorafenib treatment].
  • [Transliterated title] Naevus éruptifs sous sorafénib.
  • Among other targets, it blocks the kinase function of the RAF gene products including V600E mutant BRAF, which is frequently found in both melanoma and naevi.
  • Cutaneous side effects are frequent with sorafenib, but no naevus modification has been reported until now.
  • DISCUSSION: Eruptive melanocytic naevi have been reported in association with blistering diseases, and more generally in a setting of immunosuppression.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Benzenesulfonates / adverse effects. Nevus / chemically induced. Pyridines / adverse effects. Skin Neoplasms / chemically induced

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  • (PMID = 18929917.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
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29. Witte ME, Gerrits EG, Klaase JM, Mastboom WJ, Sterk LM: [Distinguishing nodal naevus from melanoma metastases in the sentinel node in patients with melanoma]. Ned Tijdschr Geneeskd; 2006 May 13;150(19):1072-6
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  • [Title] [Distinguishing nodal naevus from melanoma metastases in the sentinel node in patients with melanoma].
  • [Transliterated title] Een nodale naevus in de schildwachtklier bij patiënten met melanoom: onderscheid met melanoommetastase.
  • OBJECTIVE: Establishing the frequency of nodal naevi in lymph-node dissections from patients with a melanoma who have undergone a sentinel-node procedure and/or regional node dissection and distinguishing naevi from melanoma metastases.
  • METHODS: Patients with a nodal naevus in the sentinel node were selected from a database containing clinical and pathological data on all 65 patients who underwent a sentinel-node procedure for melanoma at our hospital between 1998 and 2001.
  • Also data from the pathology department on the case frequency and the nodal frequency of nodal naevi in the total number of patients with melanoma in whom a sentinel-node procedure and/or therapeutic node dissection had been carried out during the same period, were examined.
  • RESULTS: In 5 patients a nodal naevus was found in the sentinel node.
  • Distinction from melanoma metastases was made by the use of H&E colouring, localization, architectural and morphological features of the melanocyte cell clusters in the lymph node and sometimes after consultation with the National Melanoma Panel.
  • CONCLUSION: Nodal naevi in lymph nodes were not uncommon in people with melanoma and can be distinguished from the micrometastases from melanoma.
  • [MeSH-major] Lymphatic Metastasis / diagnosis. Melanoma / pathology. Nevus, Pigmented / diagnosis. Sentinel Lymph Node Biopsy / methods. Skin Neoplasms / pathology

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  • (PMID = 16733984.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Netherlands
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30. Nojavan H, Cribier B, Mehregan DR: [Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma]. Ann Dermatol Venereol; 2009 Oct;136(10):689-95
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  • [Title] [Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma].
  • [Transliterated title] Naevus de Spitz desmoplasique : analyse histopathologique et comparative avec le mélanome desmoplasique.
  • INTRODUCTION: Desmoplastic Spitz nevus is a rare variant of spitzoid tumours characterized by dermal proliferation of large epitheliod and/or fusiform melanocytes within a desmoplastic stroma, comprising thick, eosinophilic collagen bundles.
  • Histologically, this entity may be mistaken for cutaneous fibrous tumours or desmoplastic melanoma.
  • To establish useful histological criteria for differential diagnosis of desmoplastic Spitz nevus, we conducted a retrospective study comparing data concerning the clinical, demographic and histological characteristics of desmoplastic Spitz nevus and desmoplastic melanoma.
  • PATIENTS AND METHODS: We reviewed the slides for 28 cases of desmoplastic Spitz nevus and for 13 cases of desmoplastic melanoma obtained from the files of Pinkus Dermatopathology Laboratory (Monroe, MI, USA) during the period 1993-2005.
  • RESULTS: Desmoplastic Spitz nevus was more common in women (sex ratio M/F=0.4) and younger patients (mean age: 28.2 years) whereas the mean age of patients with desmoplastic melanoma was significantly higher (mean age: 75 years).
  • From a histopathological point of view, symmetry, circumscription, melanocytic maturation and involvement of adnexal structure were significantly more frequent in desmoplastic Spitz nevi.
  • The presence of melanocytic junctional nests associated with discohesive cells, variations in size and shape of the nests, lentiginous melanocytic proliferation, actinic elastosis, pagetoid spread, dermal mitosis, perineural involvement and brisk inflammatory infiltrate were significantly more frequent in desmoplastic melanoma.
  • CONCLUSION: The combination of architectural and cytological features was useful in differentiating desmoplastic Spitz nevus from desmoplastic melanoma.
  • [MeSH-major] Melanoma / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 19801251.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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31. Grosshans E, Bourlond J, Cribier B: [Nevocytic nevi associated elastic fibers hyperplasia: a type of "twin nevus"]. Ann Dermatol Venereol; 2006 May;133(5 Pt 1):435-8
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  • [Title] [Nevocytic nevi associated elastic fibers hyperplasia: a type of "twin nevus"].
  • [Transliterated title] Naevus naevocellulaires avec hyperplasie des fibres élastiques: une forme de naevus jumelé.
  • BACKGROUND: In common intradermal or compound nevi, nevocytes may be associated with other kinds of cells, tissues or lesions.
  • CASE-REPORTS AND RESULTS: In 11 nevi (10 intradermal or compound nevi and 1 blue nevus), we observed striking hyperplasia of the elastic fibers strictly limited to the nevi, with normal aspect of the elastic fibers in the surrounding reticular dermis.
  • These fibers were thicker than normal elastic fibers and showed tight connexions with nevus cells.
  • It was correlated neither with the age and sex of patients nor with the site of the excised nevi.
  • It was seen in 0.1% of excised nevi.
  • DISCUSSION: Hyperplasia of elastic fibers in some common nevi is a curiosity which may be classified together with other vascular, nervous, epithelial or connective twin lesions occasionally associated with the nevocytic nevi.
  • It has to be added to the list of so-called "twin nevi".
  • [MeSH-major] Nevus / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 16760829.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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32. Martín-González T, del Boz-González J, Vera-Casaño A: [Woolly hair nevus associated with an ipsilateral linear epidermal nevus]. Actas Dermosifiliogr; 2007 Apr;98(3):198-201
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  • [Title] [Woolly hair nevus associated with an ipsilateral linear epidermal nevus].
  • [Transliterated title] Nevus de pelo lanoso asociado a nevus epidérmico lineal ipsilateral.
  • We report a 4-year-old boy with two areas of woolly hair in the right parietotemporal region and a linear epidermal nevus in the areas of woolly hair as well as in the ipsilateral hemiface and chin.
  • [MeSH-major] Hair / abnormalities. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology


33. Triki S, Mekni A, Haouet S, Mokni M, Kchir N, Ben Osman Dhahri A, Zitouna M: [Nevus lipomatosus cutaneous superficialis: a clinico-pathological study of 13 cases]. Tunis Med; 2006 Dec;84(12):800-2
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  • [Title] [Nevus lipomatosus cutaneous superficialis: a clinico-pathological study of 13 cases].
  • [Transliterated title] Naevus lipomateux cutane superficiel : étude anatomoclinique de 13 cas.
  • Nevus lipomatosus cutaneous superficialis (NLCS) is a rare hamartomatous skin lesion histologically characterised by the presence of mature fat tissue within the dermis.
  • [MeSH-major] Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 17288284.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
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34. Collina G, Reggiani C: Recurrence of nevoid melanoma originally diagnosed as benign nevus. Pathologica; 2009 Jun;101(3):112-4
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  • [Title] Recurrence of nevoid melanoma originally diagnosed as benign nevus.
  • The lesion, which was diagnosed as a congenital compound nevus, recurred four years later as an obvious melanoma.
  • [MeSH-major] Melanoma / pathology. Neoplasm Recurrence, Local / pathology. Nevus, Intradermal / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 19886544.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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35. Rossiello L, Zalaudek I, Ferrara G, Docimo G, Giorgio CM, Argenziano G: Melanoacanthoma simulating pigmented spitz nevus: an unusual dermoscopy pitfall. Dermatol Surg; 2006 May;32(5):735-7
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  • [Title] Melanoacanthoma simulating pigmented spitz nevus: an unusual dermoscopy pitfall.
  • BACKGROUND: The starburst pattern is the dermoscopic hallmark of pigmented Spitz nevus, although it has been rarely observed in melanoma as well.
  • OBJECTIVE: To describe a case of melanoacanthoma simulating pigmented Spitz nevus.
  • MATERIAL AND METHODS: Clinical, dermoscopic, and histopathologic examinations were performed for the occurrence of a 4-mm pigmented skin lesion on the hip of a 38-year-old Caucasian woman.
  • A preoperative diagnosis of pigmented Spitz nevus was made, and the lesion was excised.
  • CONCLUSION: The starburst pattern, although diagnostic for pigmented Spitz nevus, can be rarely observed in other benign or malignant pigmented skin lesions.
  • [MeSH-major] Acanthoma / diagnosis. Dermoscopy. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16706772.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Furdova A, Pesko K, Strmen P, Kobzova M: Conjunctival nevus and melanoma. Bratisl Lek Listy; 2007;108(7):287-91
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  • [Title] Conjunctival nevus and melanoma.
  • The conjunctival nevus is one of the most common benign tumors of the ocular surface.
  • Melanomas are rare; they can arise without a preexisting conjunctival nevus, or due to malignant transformation in case of PAM (primary acquired melanosis).
  • The retrospective study analyzed 70 patients with pigmented lesion of the conjunctiva in period 1996-2006 at the Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, with the aim to determine the frequency of change in size and pigmentation of these benign lesions.
  • Multifocal and advanced melanoma, especially showing intraocular or orbital invasion, may require exenteration and/or radiotherapy to adequately extirpate the neoplasm locally.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanoma / pathology. Nevus, Pigmented / pathology

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  • (PMID = 17972544.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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37. Schwartz RA, Rothenberg J: Metastatic adenocarcinoma of breast within a benign melanocytic nevus in the context of cutaneous breast metastatic disease. J Cutan Pathol; 2010 Dec;37(12):1251-4
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  • [Title] Metastatic adenocarcinoma of breast within a benign melanocytic nevus in the context of cutaneous breast metastatic disease.
  • Metastatic breast cancer of skin may be seen in a number of forms.
  • It is rare to find it in association with a benign melanocytic nevus.
  • We describe a patient with metastatic adenocarcinoma of breast within a benign melanocytic nevus and delineate this occurrence within the context of reviewing cutaneous breast metastatic disease.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Metastasis

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  • [Copyright] Copyright © 2009 John Wiley & Sons A/S.
  • (PMID = 20002237.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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38. Lommatzsch PK, Willerding G, Nenning H, Taubert G: [Inflammatory juvenile conjunctival nevus (IJCN)]. Klin Monbl Augenheilkd; 2007 May;224(5):422-6
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  • [Title] [Inflammatory juvenile conjunctival nevus (IJCN)].
  • BACKGROUND: Pathologists may occasionally have difficulties in reliably assessing the dignity of tumour cells in histological sections, especially in nevi with junctional activity.
  • PATIENT HISTORY: This case history of a boy suffering from an inflammatory juvenile conjunctival nevus (IJCN) is reported with a follow-up period of 25 years.
  • Seven years after first surgical treatment of a histologically proven nevus, a recurrent pigmented lesion within the former operation area aroused the suspicion of it being a malignant melanoma.
  • The histological diagnosis performed by a pathologist resulted in a malignant melanoma.
  • This lesion again aroused another strong clinical suspicion of malignant transformation into a melanoma.
  • However, the histological examination of the biopsy at this time only showed benign nevus cells and areas of conjunctival melanosis without atypia.
  • DISCUSSION: Especially in young patients, IJCN must be regarded as an independent type of nevus, which might lead even experts in ophthalmic pathology to over-diagnose this lesion as a malignant melanoma.
  • A reappraisal of the former histological specimens of the first recurrent tumour by other pathologists came to the conclusion that the initial diagnosis of melanoma could not be maintained.
  • Nevertheless, we also strongly recommend follow-up examinations at regular intervals in cases of IJCN since we are aware of the fact that melanocytic tumours of the conjunctiva behave unpredictably.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Conjunctival Neoplasms / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis

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  • (PMID = 17516373.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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39. Berman EL, Shields CL, Sagoo MS, Eagle RC Jr, Shields JA: Multifocal blue nevus of the conjunctiva. Surv Ophthalmol; 2008 Jan-Feb;53(1):41-9
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  • [Title] Multifocal blue nevus of the conjunctiva.
  • Blue nevus is a congenital benign melanocytic tumor that classically occurs in the skin and carries low potential for malignant transformation.
  • We report an unusual case of widely dispersed multifocal common blue nevus of the conjunctiva simulating conjunctival melanoma.
  • Histopathology revealed six pigmented foci within the substantia propria composed of spindle-shaped cells with a wavy dendritiform configuration consistent with common blue nevus.
  • One lesion had associated racial melanosis and no lesion showed junctional activity or melanoma.
  • In conclusion, conjunctival blue nevus can be multifocal and masquerade as melanoma.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Nevus, Blue / pathology
  • [MeSH-minor] Biopsy. Cryosurgery / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Melanoma / diagnosis. Middle Aged

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  • (PMID = 18191656.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Garrido-Ríos AA, Carrera C, Puig S, Aguilera P, Salerni G, Malvehy J: Homogeneous blue pattern in an acral congenital melanocytic nevus. Dermatology; 2008;217(4):315-7
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  • [Title] Homogeneous blue pattern in an acral congenital melanocytic nevus.
  • Dermoscopy in acquired acral melanocytic nevi has been widely studied.
  • This is in contrast with the little information about the dermoscopic characteristics in congenital acral melanocytic nevi.
  • We report a 46-year-old man who was referred due to a lesion on his right sole present since childhood corresponding to an acral congenital nevus.
  • Dermoscopy showed a homogeneous blue pattern not previously described in acral benign tumors.
  • The homogeneous blue pattern has previously been associated with blue nevus and skin metastasis of melanoma.
  • The recognition of this pattern in benign acral congenital nevi is relevant in the clinical decision making concerning acral tumors.
  • [MeSH-major] Foot. Nevus, Pigmented / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Dermoscopy. Diagnosis, Differential. Humans. Male. Melanocytes / pathology. Middle Aged. Nevus, Blue / pathology

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18714159.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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41. Sahraoui W, Hajji S, Haouas N, Ladib N, Essafi A, Hmissa S, Bibi M, Khairi H: [Recurrent hydatidiform mole. Case report of 9 successive molar pregnancies]. Tunis Med; 2006 Aug;84(8):506-8
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  • [Title] [Recurrent hydatidiform mole. Case report of 9 successive molar pregnancies].
  • [Transliterated title] La mole hydatiforme recidivante. A propos d'un cas avec 9 grossesses molaires successives.
  • The recurrent hydatiform mole is rare, its frequency is lower to 1%.
  • [MeSH-major] Hydatidiform Mole / complications. Uterine Neoplasms / complications

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  • (PMID = 17175694.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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42. Taban M, Sears JE, Singh AD: Ciliary body naevus. Eye (Lond); 2007 Dec;21(12):1528-30
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  • [Title] Ciliary body naevus.
  • PURPOSE: To describe clinical, ultrasound biomicroscopy (UBM), and histopathologic characteristics of benign melanocytic tumors of the ciliary body.
  • Iridocyclectomy was performed because of documented growth in three cases, and all three cases proved to be ciliary body spindle-cell naevus.
  • CONCLUSIONS: On clinical basis and with available ancillary studies, ciliary body naevi cannot be reliably differentiated from ciliary body melanocytoma and ciliary body melanoma.
  • [MeSH-major] Ciliary Body. Nevus, Pigmented / diagnosis. Uveal Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Melanoma / diagnosis. Microscopy, Acoustic. Middle Aged

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  • (PMID = 17041573.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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43. Ramírez M, López Gutiérrez JC, Diaz M, Soto C, Miguel M, de la Torre Ramos CA, Barrena S, Ros Z, Tovar JA: [Bean or blue rubber blue nevus syndrome. Presentation of 6 patients]. Cir Pediatr; 2010 Oct;23(4):241-4
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  • [Title] [Bean or blue rubber blue nevus syndrome. Presentation of 6 patients].
  • [Transliterated title] Síndrome de bean o Blue rubber bleb nevus syndrome. presentación de 6 pacientes.
  • INTRODUCTION/AIMS: Bean or Blue Rubber Bleb Nevus Syndrome (BRBNS) is an uncommon disease characterized by multifocal venous malformations that predominantly affect the skin, soft tissues and gastrointestinal tract.
  • After, characteristic skin lesions appeared as well as chronic anemia due to digestive bleeding associated to hypofibrinogenemia.
  • [MeSH-major] Gastrointestinal Neoplasms. Nevus, Blue. Skin Neoplasms

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  • (PMID = 21520558.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] Blue rubber bleb nevus syndrome
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44. Piérard-Franchimont C, Piérard GE, Quatresooz P, Arrese JE, Rorive A, Fillet G, Grope Mosan d'Etude des Tumeurs Pigmentaires: [Hic et Nunc. Naevus or melanoma?]. Rev Med Liege; 2006 Jan;61(1):43-7
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  • [Title] [Hic et Nunc. Naevus or melanoma?].
  • [Transliterated title] Hic et Nunc. Naevus ou mélanome?
  • In Wallonia, the incidence of cutaneous melanoma has steadily increased over the past decades.
  • [MeSH-major] Melanoma / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis


45. Kazikdas KC, Onal K, Kuehnel TS, Ozturk T: An intradermal nevus of the external auditory meatus. Eur Arch Otorhinolaryngol; 2006 Mar;263(3):253-5
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  • [Title] An intradermal nevus of the external auditory meatus.
  • We herein describe a rare case of an intradermal nevus arising in the external auditory meatus.
  • Upon excisional biopsy, the tumor was diagnosed as an intradermal nevus.
  • Thus, this is a unique case of intradermal nevus obstructing the external ear canal with the patient presenting with progressive hearing loss.
  • The possibility of a benign nevomelanocytic nevus should not be underestimated when evaluating a lesion obstructing the ear canal, and all melanocytic nevi should be excised instead of biopsied to rule out melanoma.
  • [MeSH-major] Ear Canal. Nevus, Intradermal / diagnosis. Skin Neoplasms / diagnosis

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  • [Cites] Acta Otorhinolaryngol Belg. 1998;52(1):29-36 [9581194.001]
  • [Cites] Nihon Jibiinkoka Gakkai Kaiho. 1982 Sep 20;85(9):1039-46 [7175597.001]
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  • [Cites] J Otolaryngol. 1988 Aug;17(5):241-3 [3216448.001]
  • (PMID = 16012861.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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46. Situm M, Bolanca Z, Buljan M, Tomas D, Ivancić M: Nevus Spitz--everlasting diagnostic difficulties--the review. Coll Antropol; 2008 Oct;32 Suppl 2:171-6
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  • [Title] Nevus Spitz--everlasting diagnostic difficulties--the review.
  • In 1910, Darier and Civatte described in details an unusual melanocytic tumor characterized by rapid growth on the nose of a young child.
  • They could not state whether the tumor was benign or malignant.
  • In 1947, Sophie Spitz described the same lesion as juvenile melanoma in which prognosis was frequently excellent.
  • Later, the study was revised and it was concluded that juvenile melanoma was a benign tumor and can affect adults.
  • Although, the prognosis was mostly excellent, Spitz reported in one of 13 cases fatal metastases from nevus Spitz.
  • In 1999, Barnhill et al described one fatal case of the patient for whom it was thought to have typical Spitz nevus.
  • Nowadays, there is still a lack of consensus about histopathology and also a terminology of the tumors that are neither typical nevus Spitz, neither malignant melanoma.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Melanoma / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 19140279.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 28
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47. Thiagalingam S, Johnson MM, Colby KA, Zembowicz A: Juvenile conjunctival nevus: clinicopathologic analysis of 33 cases. Am J Surg Pathol; 2008 Mar;32(3):399-406
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  • [Title] Juvenile conjunctival nevus: clinicopathologic analysis of 33 cases.
  • Conjunctival nevi in children and adolescents often have histologic features that can be difficult to differentiate from malignancy.
  • We have identified a subset of childhood nevi displaying a confluent growth pattern and a lack of maturation that we have defined as juvenile conjunctival nevi (JCN), with the aim of further describing the clinicopathologic features of these lesions.
  • Lesions identified as conjunctival nevus in a tertiary referral hospital were reviewed and the subset of lesions identified as JCN were further evaluated.
  • Of the 40 conjunctival nevi identified, 33 fit the criteria for JCN.
  • Thirty-two lesions were of the compound type; one was a junctional nevus.
  • Maturation was absent in 21 of the compound nevi (66%, average age 10.3 y), and incomplete in the remaining 11 lesions (34%, average age 12.1 y).
  • The nuclei of the subepithelial nevus cells were larger than the epithelial nevus cells in 19 nevi (59%) and the same size in 13 (41%).
  • Recognition of JCN as a distinct morphologic variant of a conjunctival nevus with characteristic histologic features may help to distinguish this benign lesion from melanoma.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Nevus / pathology

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  • (PMID = 18300811.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Takata M, Murata H, Saida T: Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma. Pigment Cell Melanoma Res; 2010 Feb;23(1):64-71
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  • [Title] Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma.
  • The Clark model for melanoma progression emphasizes a series of histopathological changes beginning from benign melanocytic nevus to melanoma via dysplastic nevus.
  • Several models of the genetic basis of melanoma development and progression are based on this Clark's multi-step model, and predict that the acquisition of a BRAF mutation can be a founder event in melanocytic neoplasia.
  • However, our recent investigations have challenged this view, showing the polyclonality of BRAF mutations in melanocytic nevi.
  • Furthermore, it is suggested that many melanomas, including acral and mucosal melanomas, arise de novo, not from melanocytic nevus.
  • While mutations of the BRAF gene are frequent in melanomas on non-chronic sun damaged skin which are prevalent in Caucasians, acral and mucosal melanomas harbor mutations of the KIT gene as well as the amplifications of cyclin D1 or cyclin-dependent kinase 4 gene.
  • Amplifications of the cyclin D1 gene are detected in normal-looking 'field melanocytes', which represent a latent progression phase of acral melanoma that precedes the stage of atypical melanocyte proliferation in the epidermis.
  • Based on these observations, we propose an alternative genetic progression model for melanoma.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Gene Expression Regulation, Neoplastic / genetics. Melanoma / genetics. Mutation / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics

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  • (PMID = 19788535.001).
  • [ISSN] 1755-148X
  • [Journal-full-title] Pigment cell & melanoma research
  • [ISO-abbreviation] Pigment Cell Melanoma Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 136601-57-5 / Cyclin D1; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Number-of-references] 53
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49. Lyon VB: The spitz nevus: review and update. Clin Plast Surg; 2010 Jan;37(1):21-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The spitz nevus: review and update.
  • The Spitz nevus is a relatively common skin lesion in children and is less commonly seen in adults.
  • The lesion is defined by the presence of distinctive-appearing spindle or epithelioid cells on light microscopy in a recognizable nevus-like pattern.
  • Spitz lesions share features with melanoma on light microscopic examination.
  • When Spitz features are atypical or typical features are absent, distinction from melanoma can be difficult.
  • A spectrum of pathology of Spitz lesions can be found from lesions that are benign and typical to lesions that are atypical with melanoma-like features and frank melanoma.
  • Exciting progress has been made recently in ancillary testing that will likely be helpful in determining in more detail the biologic nature of these lesions, in better differentiating the benign Spitz lesions from malignant lesions, and in eventually improving treatment recommendations.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell. Skin Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Melanoma / diagnosis. Melanoma / therapy. Prognosis

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  • (PMID = 19914455.001).
  • [ISSN] 1558-0504
  • [Journal-full-title] Clinics in plastic surgery
  • [ISO-abbreviation] Clin Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 94
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50. Wise SR, Capra G, Martin P, Wallace D, Miller C: Malignant melanoma transformation within a nevus of Ito. J Am Acad Dermatol; 2010 May;62(5):869-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant melanoma transformation within a nevus of Ito.
  • The mongolian spot, nevus of Ota, and nevus of Ito are the most common morphologic forms of the dermal melanocytoses, a group of benign pigmented lesions histologically characterized by the presence of melanocytes within the dermis.
  • Nevus of Ito is clinically distinct, presenting with unilateral, bluish gray, patchy discolorations in the skin within the distributions of the posterior supraclavicular and lateral cutaneous brachial nerves.
  • Although all dermal melanocytoses are generally considered benign, rare cases of malignant transformation associated with nevus of Ota have been described.
  • Only one case of malignant melanoma transformation in association with nevus of Ito has previously been reported.
  • We present the second description of malignant melanoma transformation within a nevus of Ito and provide comment on the malignant potential of the dermal melanocytoses.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Melanoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • [Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20074832.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Ferrari A, Lozzi GP, Fargnoli MC, Peris K: Dermoscopic evolution of a congenital combined nevus in childhood. Dermatol Surg; 2005 Nov;31(11 Pt 1):1448-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic evolution of a congenital combined nevus in childhood.
  • BACKGROUND: A combined nevus most commonly consists of a blue nevus in combination with a Clark or Spitz nevus.
  • Dermoscopically, combined nevus can mimic melanoma owing to the presence of dermoscopic features common to both types of lesions.
  • Benign clinical and dermoscopic changes can occur in nevi over time, especially in children and young adults.
  • OBJECTIVE: To describe the dermoscopic evolution of a congenital combined nevus showing unusual dermoscopic features.
  • RESULTS: An asymptomatic plaque with a central blue area and peripheral brown pigmentation located on the back of a 13-year-old boy was diagnosed dermoscopically as combined nevus.
  • Histopathology revealed typical features of a congenital combined nevus (blue nevus + compound nevus).
  • CONCLUSION: Over time, congenital combined nevus may show clinical and dermoscopic changes in size, color, and structure.
  • Surgical excision is recommended when clinical and dermoscopic features are equivocal and the diagnosis of melanoma cannot be ruled out.
  • [MeSH-major] Dermoscopy. Nevus, Blue / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Back. Diagnosis, Differential. Humans. Male. Melanoma / diagnosis

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  • (PMID = 16416618.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Zarineh A, Kozovska ME, Brown WG, Elder DE, Rabkin MS: Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature. J Cutan Pathol; 2008 Oct;35 Suppl 1:83-6
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  • [Title] Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature.
  • Smooth muscle hamartoma (SMH) is a rare benign congenital or acquired lesion sometimes associated with Becker's nevus (Becker's melanosis).
  • We report an unusual lesion with combined features of SMH and melanocytic nevus.
  • The patient is a 49-year-old male with a history of a changing 'mole' on the left upper back.
  • The melanocytic component strongly expressed melanoma antigen recognized by T-cells-1 (MART-1) and HMB-45.
  • Unlike a recently reported case of SMH combined with a melanocytic nevus and basal cell carcinoma, the current lesion did not occur in association with a Becker's nevus.
  • [MeSH-major] Hamartoma / complications. Hamartoma / pathology. Muscle, Smooth / pathology. Nevus, Pigmented / complications. Nevus, Pigmented / congenital
  • [MeSH-minor] Actins / metabolism. Antigens, Neoplasm / metabolism. Calmodulin-Binding Proteins / metabolism. Humans. Immunohistochemistry. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544054.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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53. Seehra J, Sen P, Lloyd R, Sloan P: Intraoral Spitz naevus: a case report. Int J Oral Maxillofac Surg; 2007 Jul;36(7):661-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoral Spitz naevus: a case report.
  • Intraoral occurrences of Spitz naevus are very rare, there being only one previously documented case in the literature.
  • Here is reported a case of a young male who presented with a pigmented lesion of the upper labial mucosa which had the clinical appearance of a simple naevus.
  • Excision biopsy confirmed this to be a Spitz naevus.
  • This lesion shares histopathological similarities with malignant melanoma.
  • Spitz naevus is a benign lesion, but malignant transformation has been reported and close monitoring is recommended.
  • [MeSH-major] Lip Neoplasms / diagnosis. Nevus, Epithelioid and Spindle Cell / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Melanoma / diagnosis. Mouth Mucosa / pathology

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  • (PMID = 17391924.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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54. Vaidya DC, Schwartz RA, Janniger CK: Nevus spilus. Cutis; 2007 Dec;80(6):465-8
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  • [Title] Nevus spilus.
  • Nevus spilus (NS), also known as speckled lentiginous nevus (SLN), is a relatively common cutaneous lesion that is characterized by multiple pigmented macules or papules within a pigmented patch.
  • NS deserves its own place in the spectrum of classification of important melanocytic nevi; as a lentigo and melanocytic nevus, it has the slight potential to develop into melanoma.
  • [MeSH-major] Nevus, Pigmented. Skin Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Melanoma / pathology. Prevalence

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  • (PMID = 18246877.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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55. Song JY, Kwon JA, Park CJ: A case of Spitz nevus with multiple satellite lesions. J Am Acad Dermatol; 2005 Feb;52(2 Suppl 1):48-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of Spitz nevus with multiple satellite lesions.
  • Spitz nevus is a benign melnocytic lesion with many histologic similarities to malignant melanoma.
  • To our knowledge, a Spitz nevus with multiple satellite lesions has not been reported.
  • This paper reports a case of Spitz nevus with multiple satellite lesions on the abdomen of a 19-year-old Korean woman.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermis / pathology. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 15692514.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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56. Qian Y, Zakov ZN, Schoenfield L, Singh AD: Iris melanoma arising in iris nevus in oculo(dermal) melanocytosis. Surv Ophthalmol; 2008 Jul-Aug;53(4):411-5
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  • [Title] Iris melanoma arising in iris nevus in oculo(dermal) melanocytosis.
  • A 50-year-old white man with oculo(dermal) melanocytosis and longstanding iris nevus was found to have growth of the iris mass.
  • Excision and histopathologic examination revealed a mixed cell type malignant melanoma.
  • Benign nevus cells were present at the periphery of the tumor surrounding the entire melanoma.
  • White patients with oculo(dermal) melanocytosis have a predisposition to uveal melanoma, which is usually choroidal in origin.
  • Literature review showed only three confirmed cases of iris melanoma in this setting.
  • Two additional cases initially published as spindle A melanoma have been reclassified as iris nevi based on the modified Callender classification of uveal melanomas.
  • It is recommended that patients with oculo(dermal) melanocytosis be followed for the occurrence of uveal melanoma.
  • [MeSH-major] Iris Neoplasms / pathology. Melanoma / pathology. Neoplasms, Second Primary / pathology. Nevus of Ota / pathology. Skin Neoplasms / pathology

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  • (PMID = 18572057.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Zyrek-Betts J, Micale M, Lineen A, Chaudhuri PK, Keil S, Xue J, Thomas JE: Malignant blue nevus with lymph node metastases. J Cutan Pathol; 2008 Jul;35(7):651-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant blue nevus with lymph node metastases.
  • BACKGROUND: Malignant blue nevi arise within cellular blue nevi and contain atypical mitoses, necrosis, nuclear pleomorphism and prominent nucleoli.
  • Malignant blue nevus has been described as a distinct identity, a rare form of malignant melanoma, and a misdiagnosed melanoma.
  • METHODS: We present a patient with metastatic malignant blue nevus and studies on the histopathologic, immunohistochemical, and molecular features of the neoplasm.
  • RESULTS: Histology showed a malignant blue nevus arising in a combined intradermal and cellular blue nevus.
  • CD117 (c-kit) staining showed diffuse cytoplasmic expression within the cellular blue nevus, decreased staining in the malignant component, and variable positivity within the lymph node metastases.
  • Molecular loss of heterozygosity analysis showed different allelic patterns at the hOGG-1 locus between the melanoma and control skin specimens with a varying heterozygous allelic pattern in both the benign and malignant blue nevus.
  • CONCLUSIONS: Our case of malignant blue nevus with lymph node metastasis involved mutation of the hOGG-1 DNA repair gene.
  • CD117 showed decreased staining of the primary malignant blue nevus with marked upregulation in the metastatic lesion, unlike most metastatic melanomas.
  • Further study is needed to determine if hOGG-1 mutation or c-kit upregulation play a role in the pathogenesis of dendritic melanocytic lesions (either benign or malignant).
  • [MeSH-major] DNA Glycosylases / genetics. Ki-67 Antigen / metabolism. Loss of Heterozygosity. Nevus, Blue. Proto-Oncogene Proteins c-kit / metabolism. Skin Neoplasms
  • [MeSH-minor] Aged. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Melanoma / genetics. Polymerase Chain Reaction. Scalp / pathology. Skin / pathology. Up-Regulation

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  • (PMID = 17976211.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Ki-67 Antigen; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human
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58. De Giorgi V, Pinzani P, Salvianti F, Grazzini M, Orlando C, Lotti T, Pazzagli M, Massi D: Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis. Arch Dermatol; 2010 Oct;146(10):1120-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis.
  • BACKGROUND: The notion that only malignant melanoma cells circulate and diffuse is shared by oncologists and pathologists.
  • OBSERVATIONS: During a study of identification of circulating melanoma cells using ISET, blood samples from a 69-year-old man with an atypical melanocytic lesion on his back were evaluated.
  • The morphological features were similar to those of the excised skin tissue specimen, and the patient was subsequently diagnosed as having a congenital melanocytic nevus.
  • CONCLUSION: The finding that benign nevus cells may circulate in blood brings into question the value of tyrosinase or other melanocytic markers as a molecular surrogate for circulating melanoma cells.
  • [MeSH-major] Cell Separation / methods. Melanoma / secondary. Molecular Diagnostic Techniques / methods. Neoplastic Cells, Circulating. Skin Neoplasms / pathology


59. Isabel Zhu Y, Fitzpatrick JE: Expression of c-kit (CD117) in Spitz nevus and malignant melanoma. J Cutan Pathol; 2006 Jan;33(1):33-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of c-kit (CD117) in Spitz nevus and malignant melanoma.
  • BACKGROUND: CD117, the receptor for kit-ligand, which is a growth factor for melanocyte migration and proliferation, has shown differential staining in various benign and malignant melanocytic lesions.
  • The purpose of this study is to compare CD117 immunohistological staining in Spitz nevus versus malignant melanoma, to determine whether CD117 can aid in the diagnosis of these two lesions.
  • METHODS: CD-117 immunohistological staining was performed in 22 clinically and pathologically diagnosed pigmented lesions including 9 cases of Spitz nevus, 10 cases of primary MM and 3 cases of metastatic melanoma.
  • RESULTS: There was no significant difference in CD117 staining in either epidermis or dermis between Spitz nevi and primary melanomas.
  • However staining of metastatic melanomas is less than dermal staining of primary MM and Spitz nevus.
  • CONCLUSIONS: CD117 is unlikely a useful diagnostic tool in differentiating Spitz nevus from primary MM.
  • On the other hand, CD 117 may be useful in differentiating metastatic melanoma from primary melanoma in patients who had a history of melanoma and who present with new dermal lesions.
  • [MeSH-major] Melanoma / metabolism. Nevus, Epithelioid and Spindle Cell / metabolism. Proto-Oncogene Proteins c-kit / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 16441409.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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60. Yokogawa M, Kamakura T, Ishiguro H, Ikeda M, Kodama H: Mucinous nevus. J Dermatol; 2005 Jan;32(1):30-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous nevus.
  • These papules were densely distributed and showed epidermal nevus-like linear arrangement at some sites.
  • In mucinous nevus, the origin of cells with nevoid proliferation is obscure.
  • In contrast with common collagenous connective tissue nevus, it is hard to define the localized persistent mucin accumulation as a nevoid manifestation.
  • The present case of mucinous nevus might be caused by significantly stimulated glycosaminoglycan synthesis in a kind of epidermal nevus without extreme hyperkeratosis.
  • [MeSH-major] Mucinoses / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 15841658.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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61. Basak PY, Hofmann-Wellenhof R: [Early melanoma as opposed to a benign nevus, nevus-associated melanoma, or halo nevus with regression?]. Hautarzt; 2010 Sep;61(9):785-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Early melanoma as opposed to a benign nevus, nevus-associated melanoma, or halo nevus with regression?].
  • [Transliterated title] Frühes Melanom neben einem benignen Nävus, nävusassoziiertes Melanom oder regressiver Nävus?
  • A 43-year-old woman, in whom a melanoma associated with a melanocytic nevus had been removed 2 years previously, came for a follow-up examination presenting with two light brown to medium brown maculae measuring approximately 7x5 mm with a flat papular center.
  • The differential diagnosis on clinical grounds included a halo nevus with a second common nevus, a nevus with regression, and a melanoma associated with a nevus.
  • The diagnosis based on histopathological analysis was that of an atypical congenital nevus with regression.
  • [MeSH-major] Melanoma / pathology. Neoplasm Recurrence, Local / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • [Cites] Clin Exp Dermatol. 2003 Sep;28(5):476-80 [12950330.001]
  • [Cites] Br J Dermatol. 2004 Jan;150(1):64-71 [14746618.001]
  • [Cites] Arch Dermatol. 2006 Dec;142(12):1627-32 [17178990.001]
  • [Cites] Arch Dermatol. 2010 Apr;146(4):459-60 [20404249.001]
  • (PMID = 20814777.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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62. Miteva M, Lazova R: Spitz nevus and atypical spitzoid neoplasm. Semin Cutan Med Surg; 2010 Sep;29(3):165-73
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  • [Title] Spitz nevus and atypical spitzoid neoplasm.
  • Spitz nevus (SN) and Spitzoid malignant melanoma (SMM) represent benign and malignant counterparts at both ends of the spectrum of Spitzoid lesions.
  • Atypical Spitzoid neoplasm (ASN) is a poorly defined and characterized category of melanocytic tumors with histologic features of both benign Spitz nevi and malignant melanomas.
  • The group of ASN represents a mixture of Spitz nevi with atypical features and Spitzoid melanomas.
  • Because this group encompasses both benign and malignant lesions, and perhaps also a separate category of melanocytic tumors that behave better than conventional melanomas, some of these neoplasms can metastasize and kill patients, whereas others have no metastatic potential, and yet others might only metastasize to regional lymph nodes.
  • At this time histologic examination remains the golden standard for diagnosing these melanocytic neoplasms.
  • We also review the most recent advances in immunohistochemical and molecular diagnostics as well as discuss the controversies and dilemma regarding whether to consider sentinel lymph node biopsy for diagnostically ambiguous melanocytic neoplasms.
  • [MeSH-major] Melanoma / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Sentinel Lymph Node Biopsy. Skin Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21051010.001).
  • [ISSN] 1558-0768
  • [Journal-full-title] Seminars in cutaneous medicine and surgery
  • [ISO-abbreviation] Semin Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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63. Cramer JS, Forrest K: A survey of deployed foot problems in a desert environment. Mil Med; 2008 Apr;173(4):359-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A casual comment made regarding the amount of "mole skin" being dispensed to airmen to handle blisters, pressure points, and foot pain led to the development of an impromptu voluntary survey in an attempt to quantify the number of personnel with foot care concerns and the spectrum of those problems.
  • With only a small number of sick call visits related to foot and ankle problems, the amount of mole skin being dispensed was surprising.
  • [MeSH-major] Desert Climate. Foot. Foot Diseases / diagnosis. Military Medicine. Military Personnel. Skin Diseases / diagnosis


64. Hivnor CM, Yan AC, Honig PJ: Acne arising in an epidermal nevus. Pediatr Dermatol; 2007 Sep-Oct;24(5):534-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acne arising in an epidermal nevus.
  • Epidermal nevi are benign congenital lesions that follow Blaschko lines.
  • Epidermal nevi can demonstrate a variety of histologic patterns and contain hamartomatous hyperplasia of any epidermal or adnexal structure.
  • We present the first reported instance of acne arising strictly within a preexisting keratinocytic epidermal nevus during puberty, which is a demonstration of genetic mosaicism in pilosebaceous units.
  • [MeSH-major] Acne Vulgaris / etiology. Acne Vulgaris / pathology. Nevus / complications. Nevus / pathology


65. Patterson CR, Acland K, Khooshabeh R: Cutaneous malignant melanoma arising in an acquired naevus of Ota. Australas J Dermatol; 2009 Nov;50(4):294-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous malignant melanoma arising in an acquired naevus of Ota.
  • Naevus of Ota is a dermal melanocytosis most commonly found in black or Asian skin and is usually a benign malformation, but with a low risk of melanoma.
  • We describe a 32-year-old Caucasian man with an acquired naevus of Ota with subtle pigmentation, in which a melanocytic papule developed.
  • The lesion, deceptively, had no clinically suspicious features, but investigation revealed an aggressive cutaneous malignant melanoma, extensive orbital ring melanocytosis and metastatic brain and subsequent liver disease.
  • [MeSH-major] Melanoma / pathology. Neoplasms, Second Primary / pathology. Nevus of Ota / pathology. Orbital Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19916976.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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66. Murphy MJ, Jen M, Chang MW, Grant-Kels JM, Makkar H: Molecular diagnosis of a benign proliferative nodule developing in a congenital melanocytic nevus in a 3-month-old infant. J Am Acad Dermatol; 2008 Sep;59(3):518-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular diagnosis of a benign proliferative nodule developing in a congenital melanocytic nevus in a 3-month-old infant.
  • Small and intermediate congenital melanocytic nevi have a lifetime risk of developing melanoma estimated to range from 0% to 5%.
  • Secondary benign melanocytic proliferations commonly arise in congenital melanocytic nevi; however, some are difficult to definitively distinguish from malignant melanoma based on clinical features and conventional histology.
  • Herein, we describe the use of comparative genomic hybridization in supporting the diagnosis of a deep penetrating nevus developing within a congenital melanocytic nevus of a 3-month-old infant.
  • [MeSH-major] Melanocytes / pathology. Nevus, Pigmented / congenital. Nevus, Pigmented / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Proliferation. Chromosome Aberrations. Chromosomes, Human / genetics. Humans. Immunohistochemistry. Infant. Ki-67 Antigen / analysis. Male. Nucleic Acid Hybridization / methods. Skin / pathology

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  • (PMID = 18640742.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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67. Lee HY, Na SY, Son YM, Kang HK, Baek JO, Lee JR, Roh JY: A malignant melanoma associated with a blue nevus of the lip. Ann Dermatol; 2010 Feb;22(1):119-24

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A malignant melanoma associated with a blue nevus of the lip.
  • Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis.
  • These lesions are usually benign and stable over time.
  • However, malignant melanomas developing in or associated with a blue nevus (which is also called malignant blue nevus) have been only rarely reported.
  • A malignant blue nevus might develop in a common blue or cellular blue nevus, a giant congenital nevus or in a nevus of Ota, or it may be malignant from the start.
  • Malignant blue nevi most commonly are found on the scalp.
  • A malignant blue nevus of the lip has not been previously reported in the medical literature.
  • We report here on a patient with a malignant melanoma associated with a blue nevus of the lip.
  • The malignant melanoma was presumed to have developed from a blue nevus that was present on the upper lip of a 50-year-old male.

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  • [Cites] Cancer. 1991 May 15;67(10):2653-7 [2015566.001]
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  • (PMID = 20548900.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883390
  • [Keywords] NOTNLM ; Blue nevus / Malignant blue nevus / Malignant melanoma / Upper lip
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68. Requena C, Requena L, Sánchez-Yus E, Kutzner H, Llombart B, Sanmartín O, Botella-Estrada R, Nagore E, Serra C, Guillén C: Hypopigmented Reed nevus. J Cutan Pathol; 2008 Oct;35 Suppl 1:87-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypopigmented Reed nevus.
  • Reed nevus, also named pigmented spindle cell nevus, is a peculiar melanocytic nevus, now regarded as a variant of Spitz nevus by the majority of authors.
  • Hypopigmented Reed nevus shows all the typical features of conventional pigmented spindle cell nevus, but it does not contain abundant melanin.
  • This variant of Reed nevus is poorly described in literature, so we report five cases of hypopigmented Reed nevus and discuss its clinical and histopathological features.
  • [MeSH-major] Hypopigmentation / pathology. Nevus, Spindle Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Arm / pathology. Child. Diagnosis, Differential. Female. Humans. Keratosis, Seborrheic / pathology. Leg / pathology. Lymphangioma / pathology. Male. Melanocytes / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Nevus, Pigmented / pathology

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18547345.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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69. Palmer B, Hemphill M, Wootton C, Foshee JB, Frimberger D: Kissing nevus discovered at circumcision consult. J Pediatr Urol; 2010 Jun;6(3):318-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kissing nevus discovered at circumcision consult.
  • A divided nevus of the penis is a rare embryological occurrence.
  • The appearance of a congenital melanocytic nevus can be difficult to distinguish from penile melanosis.
  • This article presents the successful excision and histopathologic evaluation of one such nevus.
  • [MeSH-major] Circumcision, Male / methods. Foreskin. Nevus, Intradermal / diagnosis. Referral and Consultation. Skin Neoplasms / diagnosis

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  • [Copyright] Copyright (c) 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19880351.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. Zätterström U, Thor A, Nordgren H: Cervical metastasis from Spitz nevus of the buccal mucosa. Melanoma Res; 2008 Feb;18(1):36-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical metastasis from Spitz nevus of the buccal mucosa.
  • The morphology diagnosed a Spitz nevus and she underwent supplementary excision of scar tissue.
  • Cytology from fine needle aspiration indicated spread of a melanocytic tumor and she underwent a modified supraomohyiod neck dissection.
  • The finding suggests a mechanical spread of melanocytes from the Spitz nevus to the regional lymph node.
  • It is believed that this may be an example of how a Spitz tumor, although inherently benign, can spread along lymphatics in a pseudometastatic fashion.
  • To our knowledge this is the first report of an oral Spitz melanoma with metastatic behavior.
  • [MeSH-major] Head and Neck Neoplasms / secondary. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Nevus, Epithelioid and Spindle Cell / pathology
  • [MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Neck Dissection. Nevus, Pigmented / pathology

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  • (PMID = 18227706.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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71. Cyr PR: Atypical moles. Am Fam Physician; 2008 Sep 15;78(6):735-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical moles.
  • Atypical moles can be distinguished visually by clinical features of size greater than 6 mm in diameter, color variegation, indistinct borders, and textured surface.
  • All patients who have atypical moles should be counselled about sun avoidance, screening of family members, and regular skin checks at least once per year.
  • Total body photography and dermoscopy can aid in regular skin monitoring for changes in atypical moles and the emergence of new lesions.
  • The presence of multiple atypical moles increases the risk of melanoma.
  • The greatest risk of melanoma is in patients who have more than 50 atypical moles and two or more family members with melanoma (familial atypical mole and melanoma syndrome).
  • Atypical moles should be removed when they have features suggestive of malignant transformation.
  • Removing all atypical moles is neither necessary nor cost effective.
  • [MeSH-major] Nevus / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am Fam Physician. 2008 Sep 15;78(6):704, 706 [18819235.001]
  • (PMID = 18819240.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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72. Marques YM, de Lima Mde D, Raitz R, Pinto Ddos S Jr, de Sousa SO: Blue nevus: report of a case. Gen Dent; 2009 Jan-Feb;57(1):e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Blue nevus: report of a case.
  • Blue nevus is a benign, acquired melanocytic lesion that typically manifests as an asymptomatic, slate-blue or blue-black, smooth-surfaced macule or papule.
  • Intraoral melanocytic nevi are uncommon compared to those found in the skin, with the exception of the blue nevus.
  • The blue nevus is proportionally more prevalent in oral mucosa and represents the second most common form of nevus, accounting for 16.5% to 36% of all oral nevi.
  • The palate is the predominant location for blue nevi, accounting for 87% of all oral cases, although other lesions are found in this region as well.
  • This paper presents a case of common blue nevus of the hard palate in a 76-year-old woman, describes the clinical and histological aspects of the nevus, and discusses the difference between benign and malignant melanocytic lesion in the palate.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Nevus, Blue / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Melanoma / pathology. Melanoma / surgery. Palate, Hard. Treatment Outcome

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  • (PMID = 21466995.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Aoyagi S, Akiyama M, Mashiko M, Shibaki A, Shimizu H: Extensive proliferative nodules in a case of giant congenital naevus. Clin Exp Dermatol; 2008 Mar;33(2):125-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extensive proliferative nodules in a case of giant congenital naevus.
  • The rare presence of proliferative nodules in cases of giant congenital naevus can, in some cases, be potentially misdiagnosed as neonatal melanoma.
  • We report here a case of multiple, proliferative nodules found in a giant congenital naevus lesion in a female neonatal patient diagnosed with neurocutaneous melanosis.
  • Our initial clinical observations of this case suggested the possibility of primary cutaneous neonatal melanoma or skin metastasis from a melanoma in the meninges or elsewhere in the central nervous system.
  • However, histological examination revealed no sign of melanoma, abnormal mitosis, necrosis or any malignant change.
  • Pagetoid arrays of naevus cells in the junctional zone and myxoid changes present in a significant portion of the dermis led to the diagnosis of proliferative nodules.
  • Distinct histological patterns seen in the proliferative nodules in our neonatal patient were useful to differentiate between benign pigmented nodular lesions in a giant congenital naevus and malignant melanoma, and reduced the chance of misdiagnosis.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin / pathology. Skin Abnormalities / pathology. Skin Neoplasms / pathology

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  • (PMID = 17927783.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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74. Tomita M, Goto H, Muramatsu R, Usui M: Treatment of large conjunctival nevus by resection and reconstruction using amniotic membrane. Graefes Arch Clin Exp Ophthalmol; 2006 Jun;244(6):761-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of large conjunctival nevus by resection and reconstruction using amniotic membrane.
  • BACKGROUND: Nevus of the bulbar conjunctiva is a benign pigmented lesion of the ocular surface.
  • Unless a biopsy is required for ruling out malignant melanoma, a nevus is usually excised for cosmetic reasons only.
  • In this report, we present a case of a huge nevus treated by surgical excision and amniotic membrane transplantation for reconstruction of the bulbar conjunctiva.
  • RESULTS: The histopathological diagnosis was conjunctival nevus.
  • CONCLUSION: Surgical resection combined with reconstruction by amniotic membrane transplantation is effective for the treatment of large conjunctival nevus.
  • [MeSH-major] Amnion / transplantation. Conjunctival Neoplasms / surgery. Nevus, Pigmented / surgery. Ophthalmologic Surgical Procedures

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  • [Cites] Jpn J Ophthalmol. 2001 Sep-Oct;45(5):538-42 [11583680.001]
  • [Cites] Ophthalmology. 1989 Feb;96(2):147-66 [2649838.001]
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  • (PMID = 16315045.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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75. Thual N, Chevallier JM, Vuillamie M, Tack B, Leroy D, Dompmartin A: [CO2 laser therapy of verrucous epidermal nevus]. Ann Dermatol Venereol; 2006 Feb;133(2):131-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [CO2 laser therapy of verrucous epidermal nevus].
  • INTRODUCTION: Verrucous epidermal nevus are benign epidermal hyperplasias.
  • The aim of this study was to evaluate the efficacy of continuous carbon dioxide laser in the treatment of verrucous epidermal nevus.
  • MATERIAL AND METHODS: It was a retrospective study concerning all patients treated for epidermal verrucous nevus by carbon dioxide laser from 1991 to 2003.
  • The epidermal verrucous nevus was situated on the neck or on the head for 62% of them (n = 13).
  • Among these 21 patients, 86% (n = 19) estimated their skin as "cured" or "nearly normal" or "much improved".
  • This study shows that continuous wave carbon dioxide laser is an easy and effective treatment of verrucous epidermal nevus.
  • [MeSH-major] Hamartoma / surgery. Laser Therapy. Skin Diseases / surgery

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  • (PMID = 16508596.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 36
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76. Wu CY, Gao HW, Chiang CP: Malignant amelanotic melanoma developing from an intradermal naevus in a patient with oculocutaneous albinism. Clin Exp Dermatol; 2009 Dec;34(8):e590-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant amelanotic melanoma developing from an intradermal naevus in a patient with oculocutaneous albinism.
  • Histopathologically, the tumour revealed benign naevus cells in the upper dermis and atypical malignant tumour cells in the deeper dermis.
  • Amelanotic malignant melanoma (MM) originating from a pre-existing intradermal naevus was diagnosed.
  • [MeSH-major] Albinism, Oculocutaneous / pathology. Melanoma / pathology. Nevus, Intradermal / pathology. Skin Neoplasms / pathology

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  • (PMID = 19486065.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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77. Ghaninezhad H, Ehsani AH, Mansoori P, Taheri A: Naevus comedonicus of the scalp. J Eur Acad Dermatol Venereol; 2006 Feb;20(2):184-5
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  • [Title] Naevus comedonicus of the scalp.
  • We report the case of a 3-year-old boy with naevus comedonicus, characterized by confluent clusters of dilated follicular orifices plugged with keratinous material that resemble open comedones, located on the scalp.
  • [MeSH-major] Folliculitis / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16441628.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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78. Yazici AC, Ikizoglu G, Baz K, Polat A, Ustunsoy D: Cerebriform intradermal nevus. Pediatr Dermatol; 2007 Mar-Apr;24(2):141-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebriform intradermal nevus.
  • Cerebriform intradermal nevus is a rare form of cutis verticis gyrata.
  • Clinically it manifests as a scalp deformity resembling the surface of the brain, with cerebriform morphologic characteristics.
  • Degeneration into malignant melanoma has been reported.
  • Herein, a cerebriform intradermal nevus of the scalp in a 7-year-old girl is reported.
  • The clinical and histopathologic presentations of cerebriform intradermal nevus are described and the therapeutic possibilities discussed.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Nevus, Intradermal / pathology. Scalp. Skin Neoplasms / pathology

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  • (PMID = 17461810.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
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79. Cash SH, Dever TT, Hyde P, Lee JB: Epidermolysis bullosa nevus: an exception to the clinical and dermoscopic criteria for melanoma. Arch Dermatol; 2007 Sep;143(9):1164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermolysis bullosa nevus: an exception to the clinical and dermoscopic criteria for melanoma.
  • BACKGROUND: Large acquired melanocytic nevi that occur in patients with epidermolysis bullosa (EB), referred to as EB nevi, may pose a diagnostic challenge because of their clinical and dermoscopic resemblance to melanoma.
  • These unconventional melanocytic nevi have been encountered in all categories of hereditary EB, most of them in childhood.
  • Although some of the reported cases have an alarming clinical appearance that is indistinguishable from melanoma, long-term follow-up has confirmed the benign nature of these rarely encountered melanocytic lesions.
  • The histopathologic patterns of these nevi range from a banal congenital pattern to the problematic persistent pseudomelanoma pattern.
  • OBSERVATION: We describe the clinical, dermoscopic, and histopathologic features of a large EB nevus in a toddler.
  • Clinically, the lesion was markedly asymmetrical and irregularly pigmented with foci of stippled pigmentation and scarring, which easily fulfilled the ABCD criteria for melanoma.
  • Histopathologically, a pattern of persistent melanocytic neoplasm was observed.
  • CONCLUSION: Epidermolysis bullosa nevi are dynamic melanocytic lesions that may simulate melanoma.
  • [MeSH-major] Dermoscopy. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis


80. Alfaro A, Torrelo A, Hernández A, Zambrano A, Happle R: [Becker nevus syndrome]. Actas Dermosifiliogr; 2007 Nov;98(9):624-6
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  • [Title] [Becker nevus syndrome].
  • Becker nevus is a hyperpigmented hamartoma with an irregular outline and often hairy.
  • Becker nevus is sometimes associated with other muscular, skeletal, or cutaneous abnormalities such as ipsilateral breast hypoplasia or scoliosis.
  • This characteristic phenotype of Becker nevus associated with unilateral breast hypoplasia or other abnormalities is referred to as Becker nevus syndrome.
  • Although the lesions usually become apparent during adolescence, they are present from birth and represent part of the spectrum of so-called epidermal nevus syndromes.
  • We present 4 cases of Becker nevus syndrome in which Becker nevus was associated with ipsilateral breast hypoplasia and, less consistently, other abnormalities.
  • [MeSH-major] Hamartoma / pathology. Hyperpigmentation / pathology. Skin Diseases / pathology
  • [MeSH-minor] Adolescent. Breast / abnormalities. Child. Humans. Male. Nevus. Syndrome

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  • (PMID = 17961453.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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81. El Ghelbazouri N, Ismaili N, Ahrich N, Benarafa A, Senouci K, Mansouri F, Hassam B: [Nevus comedonicus syndrome]. Ann Dermatol Venereol; 2007 Aug-Sep;134(8-9):663-6
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  • [Title] [Nevus comedonicus syndrome].
  • BACKGROUND: Nevus comedonicus is a rare disease and diagnosis is made chiefly on clinical grounds.
  • It may occur in isolation, or in rare cases, it may be combined with other congenital malformations to constitute nevus comedonicus syndrome.
  • Clinical diagnosis of nevus comedonicus was confirmed by histological examination of the skin.
  • DISCUSSION: Nevus comedonicus is one of the rarest forms of cutaneous nevus.
  • This case is original as regards the extent and topography of the nevus covering the left side of the patient's body and its association with congenital cataract potentially indicating nevus comedonicus syndrome.
  • This syndrome is extremely rare and belongs to a large group of epidermal nevus syndromes characterised by association of nevus and extracutaneous malformations, particularly ocular, skeletal and neurological.
  • [MeSH-major] Nevus / congenital. Skin Neoplasms / congenital

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  • (PMID = 17925691.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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82. Cosendey FE, Martinez NS, Bernhard GA, Dias MF, Azulay DR: Becker nevus syndrome. An Bras Dermatol; 2010 May-Jun;85(3):379-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Becker nevus syndrome.
  • Becker nevus syndrome is a phenotype characterized by the fundamental presence of Becker's nevus with ipsilateral hypoplasia of the breast or other skin, skeletal and/or muscular disorders.
  • This syndrome generally originates at birth, intensifies significantly in adolescence and is one of the syndromes that constitute epidermal nevus syndrome.
  • To the best of our knowledge, this is the first case published in the Brazilian literature of Becker nevus syndrome associated with Becker's nevus, ipsilateral breast hypoplasia and scoliosis in a 14-year-old girl.
  • [MeSH-major] Breast / abnormalities. Hamartoma / pathology. Hypertrichosis / pathology. Skin Diseases / pathology

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  • (PMID = 20676475.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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83. Pouryazdanparast P, Newman M, Mafee M, Haghighat Z, Guitart J, Gerami P: Distinguishing epithelioid blue nevus from blue nevus-like cutaneous melanoma metastasis using fluorescence in situ hybridization. Am J Surg Pathol; 2009 Sep;33(9):1396-400
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  • [Title] Distinguishing epithelioid blue nevus from blue nevus-like cutaneous melanoma metastasis using fluorescence in situ hybridization.
  • Blue nevus (BN)-like cutaneous melanoma metastasis is a well-recognized variant of melanoma metastasis.
  • These lesions may clinically and histologically simulate benign blue nevi.
  • The histologic changes may be indistinguishable from conventional blue nevi or epithelioid blue nevi (EBN), a benign dermal-based melanocytic neoplasm with epithelioid morphology and heavily pigmented cytoplasm.
  • Distinguishing BN-like cutaneous melanoma metastasis from benign conventional or EBN is important for staging and treatment.
  • We evaluated a fluorescence in situ hybridization (FISH) assay using probes targeting 6p25 (RREB1), 6q23 (MYB), 11q13 (CCND1), and centromere 6 (Cep6) with previously determined criteria, to distinguish EBN and BN-like melanoma metastasis.
  • Ten BN-like cutaneous melanoma metastatic lesions and 10 EBN were blindly evaluated with the above mentioned FISH probes.
  • FISH enumeration and criteria for diagnosis of melanoma was as previously described.
  • Nine of 10 BN-like cutaneous metastatic lesions showed significant aberrations and met previously established criteria for melanoma.
  • None of the EBN cases showed evidence of significant copy number changes or met FISH criteria for a diagnosis of melanoma.
  • FISH is an important diagnostic adjunct for melanocytic neoplasms.
  • In this study, we show that a FISH assay targeting 6p25, 6q23, 11q13, and centromere 6 can distinguish EBN from BN-like metastatic melanoma with high accuracy.
  • [MeSH-major] Epithelioid Cells / pathology. In Situ Hybridization, Fluorescence / methods. Melanoma / diagnosis. Nevus, Blue / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Aberrations. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Young Adult


84. Williams D, Hodgetts V, Gupta J: Recurrent hydatidiform moles. Eur J Obstet Gynecol Reprod Biol; 2010 May;150(1):3-7
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  • [Title] Recurrent hydatidiform moles.
  • Hydatidiform moles (HMs) are abnormal conceptions of excessive trophoblast development resulting in abnormal human pregnancies with no embryo and cystic degeneration of the chorionic villi.
  • Hydatidiform moles occur quite frequently and although recurrence is rare, women who have experienced one molar pregnancy should be aware that they are at an increased risk of a further molar pregnancy in comparison to other women in the general population.
  • In these women the recurrent molar pregnancies may be non-familial, referred to as recurrent molar hydatidiform moles in this article, or may result from an inherited predisposition, which we refer to as familial recurrent hydatidiform moles.
  • We use the term familial biparental hydatidiform moles (FBHMs) for cases in which the parental contribution to the moles has been investigated and found to be biparental.
  • This review considers our current understanding about the aetiology of HMs and explores the mechanisms of both types of recurrent hydatidiform moles.
  • [MeSH-major] Hydatidiform Mole

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20171777.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / NLRP7 protein, human
  • [Number-of-references] 37
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85. Dhouib RS, Sassi S, Jbeli A, Driss M, Mrad K, Abbes I, Ben Romdhane K: Desmoplastic spitz nevus: report of a case and review of the literature. Pathologica; 2008 Jun;100(3):181-4
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  • [Title] Desmoplastic spitz nevus: report of a case and review of the literature.
  • Desmoplastic spitz nevus (DSN) is an uncommon melanocytic lesion.
  • The histologic features of this benign tumour may mimic those of certain benign (dermatofibroma and desmoplastic cellular blue nevus) or malignant (metastatic carcinoma and malignant melanoma) neoplasms.
  • The histologic presentation of this benign lesion mimics both benign and malignant neoplasms.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 18841824.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 15
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86. De Panfilis G, Ferrari D, Santoro S, Ricci R, Lombardi M, Pedrazzi G, Pepe C, Cortelazzi C, Santini M: Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis? Br J Dermatol; 2009 Mar;160(3):600-8
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  • [Title] Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis?
  • BACKGROUND: An excess of intracellular beta-catenin protein is triggered by various genetic alterations in melanoma cell lines, and has been suggested to play a role in melanoma tumorigenesis.
  • OBJECTIVES: To investigate the role played in vivo by beta-catenin in melanoma tumorigenesis, we compared the cytoplasmic detection of beta-catenin in benign melanocytic cells vs. malignant melanoma cells presumably generated from these benign melanocytic cells.
  • For this purpose, melanocytic naevi occurring in association with melanoma, which were suggested to be melanoma precursors, were compared with their associated melanoma for beta-catenin cytoplasmic immunoreactivity.
  • METHODS: Fifty-seven consecutive cases of primary cutaneous melanoma were considered, and 15 of them were found to be associated with a melanocytic naevus portion.
  • The naevus portion showed features of acquired melanocytic naevus (total 12 cases: five dysplastic, seven intradermal) or congenital growth pattern naevus (total three cases: one superficial, two deep).
  • RESULTS: Virtually all primary cutaneous melanomas, including those associated with a naevus portion, showed cytoplasmic beta-catenin positivity.
  • However, the intradermal naevus portion was consistently cytoplasmic beta-catenin negative, while both the dysplastic and the congenital naevus portions were cytoplasmic beta-catenin positive.
  • CONCLUSIONS: Beta-catenin excess may play a role in melanoma tumorigenesis, because beta-catenin cytoplasmic reactivity was found in primary cutaneous melanoma but not in its associated intradermal naevus precursor.
  • As, however, beta-catenin cytoplasmic reactivity was detected not only in primary cutaneous melanoma but also in its associated dysplastic/congenital naevus precursors, beta-catenin stabilization alone is not sufficient to play a decisive role for melanoma onset.
  • [MeSH-major] Cell Transformation, Neoplastic / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cytoplasm / metabolism. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Young Adult

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  • (PMID = 19183173.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / beta Catenin
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87. Gonzalez ME, Jabbari A, Tlougan BE, Mandal R, Schaffer JV: Epidermal nevus. Dermatol Online J; 2010;16(11):12
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  • [Title] Epidermal nevus.
  • A healthy 25-year-old man presented with a widespread, non-organoid, non-epidermolytic epidermal nevus.
  • [MeSH-major] Keratoderma, Palmoplantar / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Hamartoma / diagnosis. Hamartoma / pathology. Humans. Hyperpigmentation / diagnosis. Hyperpigmentation / pathology. Male. Nevus, Sebaceous of Jadassohn / diagnosis. Nevus, Sebaceous of Jadassohn / pathology


88. Kim CW, Oh SJ, Rho YS, Cho SJ, Koh ES: A case of dysplastic nevus of the external auditory canal presenting with conductive hearing loss. Yonsei Med J; 2009 Dec 31;50(6):845-7
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  • [Title] A case of dysplastic nevus of the external auditory canal presenting with conductive hearing loss.
  • A nevus which is a benign melanocytic neoplasm rarely occurs within the external auditory canal (EAC).
  • A dysplastic nevus presents atypical features both clinically and histologically, and is important as a potential precursor for melanoma.
  • We present a case of a 33-year-old female patient with a dysplastic nevus in her EAC.
  • The mass showed clinically characteristic findings of a melanocytic nevus.
  • Histopathological examination revealed an intradermal nevus with atypical melanocytes without pleomorphism.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Dysplastic Nevus Syndrome / pathology. Ear Canal / pathology. Hearing Loss, Conductive / etiology

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  • [Cites] Arch Dermatol. 2001 Jul;137(7):917-20 [11453811.001]
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  • (PMID = 20046428.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2796414
  • [Keywords] NOTNLM ; External auditory canal / conductive hearing loss / dysplastic nevus / intradermal nevus
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89. Mason MJ, Lucas SJ, Wise ER, Stein RS, Duer MJ: Ossicular density in golden moles (Chrysochloridae). J Comp Physiol A Neuroethol Sens Neural Behav Physiol; 2006 Dec;192(12):1349-57
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  • [Title] Ossicular density in golden moles (Chrysochloridae).
  • The densities of middle ear ossicles of golden moles (family Chrysochloridae, order Afrosoricida) were measured using the buoyancy method.
  • The malleus density of the desert golden mole Eremitalpa granti (2.44 g/cm3) was found to be higher than that reported in the literature for any other terrestrial mammal, whereas the ossicles of other golden mole species are not unusually dense.
  • [MeSH-major] Ear Ossicles / anatomy & histology. Moles / anatomy & histology

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  • (PMID = 16944164.001).
  • [ISSN] 0340-7594
  • [Journal-full-title] Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
  • [ISO-abbreviation] J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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90. Bron JL, Jaspars EH, Molenkamp BG, Meijer S, Mooi WJ, van Leeuwen PA: [Three patients with a Spitz naevus that later turned out to be a melanoma]. Ned Tijdschr Geneeskd; 2005 Aug 13;149(33):1852-8
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  • [Title] [Three patients with a Spitz naevus that later turned out to be a melanoma].
  • [Transliterated title] Drie patiënten met op Spitz-naevus gelijkende afwijkingen die later een melanoom bleken te zijn.
  • A melanocytic lesion was removed from each of three patients: 2 men aged 37 and 65 and 1 woman aged 45.
  • The preferred diagnosis was 'Spitz naevus'.
  • The histopathological distinction between Spitz naevus and melanoma is often very difficult.
  • Some melanocytic lesions, however, cannot be categorised with confidence as being either benign (Spitz naevus) or malignant (spitzoid melanoma).
  • [MeSH-major] Melanoma / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16128184.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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91. Nino M, Brunetti B, Delfino S, Brunetti B, Panariello L, Russo D: Spitz nevus: follow-up study of 8 cases of childhood starburst type and proposal for management. Dermatology; 2009;218(1):48-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spitz nevus: follow-up study of 8 cases of childhood starburst type and proposal for management.
  • Spitz nevus is an uncommon, benign melanocytic neoplasm that shares many clinical and histological features with melanoma.
  • We present our experience in the management of Spitz nevus by rigorous dermoscopic long-term follow-up of 8 Spitz nevi in patients younger than 12 years.
  • The aim of this paper is to better understand the long-term modifications of nevi with starburst pattern to avoid surgical excision of these lesions in the pediatric age group.
  • [MeSH-major] Dermoscopy. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18832809.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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92. Hafner C, Klein A, Landthaler M, Vogt T: Clonality of basal cell carcinoma arising in an epidermal nevus. New insights provided by molecular analysis. Dermatology; 2009;218(3):278-81
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  • [Title] Clonality of basal cell carcinoma arising in an epidermal nevus. New insights provided by molecular analysis.
  • Non-organoid non-epidermolytic (keratinocytic) epidermal nevi are benign congenital skin lesions following the lines of Blaschko.
  • The occurrence of epithelial tumors in epidermal nevi of this type is very rare, and it remains elusive whether these lesions are clonally related or represent a simple collision of independent tumors.
  • We report a case of a patient who developed 2 basal cell carcinomas in an extensive epidermal nevus on the trunk.
  • Molecular analysis of a biopsy containing both basal cell carcinoma and epidermal nevus revealed a PIK3CA mutation.
  • Further analysis suggested that this mutation is present in the basal cell carcinoma rather than in the epidermal nevus.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Nevus / genetics. Skin Neoplasms / genetics

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  • [Copyright] 2008 S. Karger AG, Basel
  • (PMID = 19122450.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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93. Ro YS, Ko JY: Linear congenital Becker nevus. Cutis; 2005 Feb;75(2):122-4
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  • [Title] Linear congenital Becker nevus.
  • Becker nevus is an acquired disorder that usually manifests in late childhood or adolescence as a hyperpigmented hypertrichotic patch usually located on the upper trunk or proximal upper extremities.
  • Only a few cases of congenital and familial Becker nevus have been described.
  • We describe a case of linear congenial Becker nevus following Blaschko line that appeared at birth on the right shoulder, with hypertrichosis developing 4 years later.
  • [MeSH-major] Hyperpigmentation / pathology. Hypertrichosis / diagnosis. Nevus, Intradermal / congenital. Nevus, Intradermal / pathology

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  • (PMID = 15773534.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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94. Lebeau S, Braun RP, Masouyé I, Perrinaud A, Harms M, Borradori L: Acquired melanocytic naevus in childhood vulval pemphigoid. Dermatology; 2006;213(2):159-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acquired melanocytic naevus in childhood vulval pemphigoid.
  • BACKGROUND: Eruptive epidermolysis bullosa (EB) naevi comprise a subset of melanocytic naevi with atypical features that characteristically occur in areas of former blistering in patients suffering from hereditary EB.
  • In the course of the disease, she developed an atypical melanocytic naevus on the left labium at a site of former blistering.
  • Although its clinical and dermoscopic features resembled malignant melanoma, the lesion completely regressed clinically during the 24-month follow-up.
  • CONCLUSION: This is the first report describing the development of a melanocytic naevus at sites of blistering in an auto-immune subepidermal blistering disease in childhood.
  • Our observation extends the spectrum of disorders, in addition to the group of congenital EB, in which 'eruptive' atypical melanocytic naevi may occur.
  • [MeSH-major] Nevus, Pigmented / complications. Pemphigoid, Bullous / complications. Skin Neoplasms / complications. Vulvar Diseases / complications

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16902297.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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95. Fernandes C, Agrawal A, Shreshtha BB, Yogi N, Cherian I: Becker's nevus syndrome with quadriparesis. BMJ Case Rep; 2010;2010
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  • [Title] Becker's nevus syndrome with quadriparesis.
  • Histopathological examination of the skin revealed findings consistent with Becker's nevus.
  • Based on the patient's clinical presentation and investigations, a diagnosis of Becker's nevus syndrome was made.
  • The authors review Becker's nevus syndrome and its clinical manifestations below.
  • [MeSH-major] Nevus / congenital. Nevus / diagnosis. Quadriplegia / congenital. Quadriplegia / diagnosis. Skin Neoplasms / congenital. Skin Neoplasms / diagnosis

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  • [Cites] Arch Dermatol. 1981 Apr;117(4):243 [7212749.001]
  • [Cites] J Am Acad Dermatol. 1984 Feb;10(2 Pt 1):235-8 [6715592.001]
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  • (PMID = 22798308.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] Becker Nevus Syndrome
  • [Other-IDs] NLM/ PMC3028056
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96. Murphy BW, Webster RJ, Turlach BA, Quirk CJ, Clay CD, Heenan PJ, Sampson DD: Toward the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy. J Biomed Opt; 2005 Nov-Dec;10(6):064020
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Toward the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy.
  • We describe a study of the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy.
  • Spectra are collected at specific locations on 120 pigmented lesions selected by clinicians as possible melanoma, including 64 histopathologically diagnosed as melanoma.
  • A classifier distinguishing between benign and malignant lesions performs with sensitivity/specificity of between 6469% and 7278%.
  • Classifiers between pairs of the group common nevus, dysplastic nevus, in situ melanoma, and invasive melanoma show better or similar performance than the benign/malignant classifier, and analysis provides evidence that different spectral features are needed for each pair of groups.
  • This indicates that multiple discriminant systems are likely to be required to distinguish between melanoma and similar lesions.
  • [MeSH-major] Diagnosis, Computer-Assisted / methods. Dysplastic Nevus Syndrome / diagnosis. Fiber Optic Technology / instrumentation. Melanoma / diagnosis. Skin Neoplasms / diagnosis. Spectrum Analysis / instrumentation. Spectrum Analysis / methods

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  • (PMID = 16409085.001).
  • [ISSN] 1083-3668
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Validation Studies
  • [Publication-country] United States
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97. Chatproedprai S, Wananukul S, Prasarnnaem T, Noppakun N: Epidermal nevus syndrome. Int J Dermatol; 2007 Aug;46(8):858-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal nevus syndrome.
  • Epidermal nevus syndrome is a group of congenital neurocutaneous disorders characterized by epidermal nevi in association with cerebral, ocular, skeletal, and sometimes cardiac and renal abnormalities.
  • These nevi have been classified according to their predominant component.
  • We described a child presenting with inflammatory linear verrucous epidermal nevus on the head, which is an uncommon location.
  • [MeSH-major] Abnormalities, Multiple / diagnosis. Eye Neoplasms / radiography. Hamartoma / pathology. Nevus / diagnosis. Skin Neoplasms / diagnosis


98. Chen W: Alopecia areata universalis sparing nevus flammeus. Dermatology; 2005;210(3):227-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alopecia areata universalis sparing nevus flammeus.
  • Alopecia areata is a common form of nonscarring hair disorder of unclear etiology.
  • Cases with alopecia areata sparing congenital melanocytic nevi have been described.
  • We report a 30-year-old man presenting with rapidly progressing alopecia areata universalis, which spared a large nevus flammeus on the left parietal scalp.
  • Our case gives further evidence to the notion that nevus as genetic mosaic may show genetically determined resistance to alopecia areata.

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  • (PMID = 15785052.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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99. Terenzi V, Indrizzi E, Buonaccorsi S, Leonardi A, Pellacchia V, Fini G: Nevus sebaceus of Jadassohn. J Craniofac Surg; 2006 Nov;17(6):1234-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus sebaceus of Jadassohn.
  • The nevus sebaceus of Jadassohn (SNJ) is a hamartomatous disorder of the skin and its adnexa pertaining to the group of "organoid nevi,'' most frequently involving the face and scalp.

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  • (PMID = 17119437.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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100. Kaw P, Carlson A, Meyer DR: Nevus lipomatosus (pedunculated lipofibroma) of the eyelid. Ophthal Plast Reconstr Surg; 2005 Jan;21(1):74-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus lipomatosus (pedunculated lipofibroma) of the eyelid.
  • Nevus lipomatosus is a rare connective tissue nevus characterized by mature adipose tissue within the dermis.
  • Excisional biopsy revealed a polypoid mass formed of mature adipocytes within the dermis and subconjunctival mucosa consistent with nevus lipomatosus.
  • This is the first case of nevus lipomatous to our knowledge to be reported on the eyelid.
  • Nevus lipomatous or pedunculated lipofibroma can arise on the eyelid and should be considered in the differential diagnosis of eyelid tumors.
  • [MeSH-major] Eyelid Neoplasms / pathology. Lipomatosis / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 15677959.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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