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1. Zhang HJ, Siu MK, Wong ES, Wong KY, Li AS, Chan KY, Ngan HY, Cheung AN: Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. Placenta; 2008 Jun;29(6):549-54
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  • By methylation-specific PCR, we observed both methylated and unmethylated Oct4 alleles in all 25 first trimester and 10 term placentas while 33% (18/54) of hydatidiform moles, and two choriocarcinoma cell line (JEG3 and JAR), only displayed methylated Oct4 allele.
  • By quantitative TaqMan real-time PCR, Oct4 mRNA was significantly reduced in hydatidiform moles (P=0.04), JEG3 and JAR (P=0.024) when compared with normal placentas.

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  • (PMID = 18440631.001).
  • [ISSN] 0143-4004
  • [Journal-full-title] Placenta
  • [ISO-abbreviation] Placenta
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Hydroxamic Acids; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / RNA, Messenger; 3X2S926L3Z / trichostatin A; 776B62CQ27 / decitabine; EC 2.1.1.- / DNA Modification Methylases; M801H13NRU / Azacitidine
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2. Malowicki MG, Shellhammer TH: Isomerization and degradation kinetics of hop (Humulus lupulus) acids in a model wort-boiling system. J Agric Food Chem; 2005 Jun 1;53(11):4434-9
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  • Activation energy was experimentally determined to be 98.6 kJ per mole for isomerization, and 108.0 kJ per mole for degradation.

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  • (PMID = 15913306.001).
  • [ISSN] 0021-8561
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acids; 0 / Cyclohexenes; 0 / Solutions; 0 / Terpenes; KHB4767H3K / humulon
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3. Martí N, Jordá E, Martínez E, Gámez L, Ramón MD: Widespread nevus spilus associated with torsion dystonia: a case report. Pediatr Dermatol; 2010 Nov-Dec;27(6):654-6
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  • [Title] Widespread nevus spilus associated with torsion dystonia: a case report.
  • Usually speckled lentiginous nevus or nevus spilus is a small solitary lesion consisting of a light tan patch with numerous dark brown macules or papules (or both) within it.
  • It is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or speckled lentiginous nevus syndrome.
  • We hereby report a 6-year-old Caucasian patient with systematized nevus spilus associated with torsion dystonia, a combination not published thus far.
  • [MeSH-major] Dystonia Musculorum Deformans / complications. Nevus, Pigmented / complications. Skin Neoplasms / complications


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4. Mathias RT, Wang H: Local osmosis and isotonic transport. J Membr Biol; 2005 Nov;208(1):39-53
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  • Osmotically driven water flow, u (cm/s), between two solutions of identical osmolarity, c(o) (300 mM: in mammals), has a theoretical isotonic maximum given by u = j/c(o), where j (moles/cm(2)/s) is the rate of salt transport.

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  • (PMID = 16596445.001).
  • [ISSN] 0022-2631
  • [Journal-full-title] The Journal of membrane biology
  • [ISO-abbreviation] J. Membr. Biol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY006391; United States / NEI NIH HHS / EY / EY06391
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isotonic Solutions
  • [Other-IDs] NLM/ NIHMS9554; NLM/ PMC1752196
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5. Asher RJ, Lehmann T: Dental eruption in afrotherian mammals. BMC Biol; 2008;6:14
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  • In contrast, morphological data uniting its diverse constituents, including elephants, sea cows, hyraxes, aardvarks, sengis, tenrecs and golden moles, have been difficult to identify.
  • RESULTS: Although data on the absolute timing of eruption in sengis, golden moles and tenrecs are still unknown, craniometric comparisons for ontogenetic series of these taxa show that considerable skull growth takes place prior to the complete eruption of the permanent cheek teeth.
  • Specimens showing less than half (sengis, golden moles) or two-thirds (tenrecs, hyraxes) of their permanent cheek teeth reach or exceed the median jaw length of conspecifics with a complete dentition.
  • CONCLUSION: Morphological characteristics shared by such physically disparate animals such as elephants and golden moles are not easy to recognize, but are now known to include late eruption of permanent teeth, in addition to vertebral anomalies, testicondy and other features.

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  • (PMID = 18366669.001).
  • [ISSN] 1741-7007
  • [Journal-full-title] BMC biology
  • [ISO-abbreviation] BMC Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2292681
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6. Palazzi MA, Ober MD, Abreu HF, Cardinalli IA, Isaac CR, Odashiro AN, Burnier Jr MN: Congenital uveal malignant melanoma: a case report. Can J Ophthalmol; 2005 Oct;40(5):611-5
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  • [Title] Congenital uveal malignant melanoma: a case report.
  • Enucleation performed in the first weeks of life confirmed the diagnosis of diffuse uveal malignant melanoma with extraocular extension.
  • He subsequently developed cutaneous and ocular pigmented lesions, including 2 choroidal nevi located within the posterior pole and a benign conjunctival lesion in the opposite eye, in addition to malignant melanoma of the skin.
  • We believe this represents the fourth case ever reported in the literature and the longest follow-up of a congenital malignant melanoma originating within the eye.

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  • (PMID = 16391626.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide
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7. Gönül M, Soylu S, Gül U, Aslan E, Unal T, Ergül G: Giant congenital melanocytic naevus associated with Dandy-Walker malformation, lipomatosis and hemihypertrophy of the leg. Clin Exp Dermatol; 2009 Jul;34(5):e106-9
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  • [Title] Giant congenital melanocytic naevus associated with Dandy-Walker malformation, lipomatosis and hemihypertrophy of the leg.
  • Malignant melanoma was excluded by histopathological examinations of multiple biopsy specimens obtained from the pigmented lesions.
  • Neurocutaneous melanosis is a rare combined abnormality of the skin and central nervous system.
  • A few case reports relating to the coexistence of giant congenital melanocytic naevus, lipomatosis and hemihypertrophy have been published in the literature.
  • We report this very rare case of giant melanocytic naevus with lipomatosis, hemihypertrophy of the leg, and DWM.
  • [MeSH-major] Dandy-Walker Syndrome / diagnosis. Leg / pathology. Lipomatosis / diagnosis. Neurocutaneous Syndromes / diagnosis. Nevus, Pigmented / diagnosis

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  • (PMID = 19438567.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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8. Hernández A, Torrelo A: [Recent data on the risk of malignancy in congenital melanocytic nevi: the continuing debate on treatment]. Actas Dermosifiliogr; 2008 Apr;99(3):185-9
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  • [Title] [Recent data on the risk of malignancy in congenital melanocytic nevi: the continuing debate on treatment].
  • [Transliterated title] Ultimos datos sobre el riesgo de malignización de los nevus melanocíticos congénitos: el debate sobre el tratamiento continúa.
  • Congenital melanocytic nevi (CMN) have traditionally been considered a risk factor for the appearance of melanoma, but the true incidence of malignancy is unknown.
  • [MeSH-major] Nevus, Pigmented / congenital. Nevus, Pigmented / therapy. Skin Neoplasms / congenital. Skin Neoplasms / therapy

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  • [CommentIn] Actas Dermosifiliogr. 2009 Jan-Feb;100(1):84-5 [19268122.001]
  • (PMID = 18358193.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 26
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9. Vaidya DC, Schwartz RA, Janniger CK: Nevus spilus. Cutis; 2007 Dec;80(6):465-8
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  • [Title] Nevus spilus.
  • Nevus spilus (NS), also known as speckled lentiginous nevus (SLN), is a relatively common cutaneous lesion that is characterized by multiple pigmented macules or papules within a pigmented patch.
  • NS deserves its own place in the spectrum of classification of important melanocytic nevi; as a lentigo and melanocytic nevus, it has the slight potential to develop into melanoma.
  • [MeSH-major] Nevus, Pigmented. Skin Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Melanoma / pathology. Prevalence


10. van Engen-van Grunsven AC, van Dijk MC, Ruiter DJ, Klaasen A, Mooi WJ, Blokx WA: HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features. Am J Surg Pathol; 2010 Oct;34(10):1436-41
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  • It is often very difficult to confidently distinguish benign and malignant Spitz lesions, and a diagnosis of Spitz tumor of unknown malignant potential (STUMP) is rendered.
  • To address this problem, we performed molecular genetic analysis in a large group of Spitz tumors (93 Spitz nevi and 77 STUMPs) and identified a subgroup of 24 lesions harboring a HRAS mutation.
  • In 7 of these 24 cases (29%) melanoma had been the initial diagnosis, or an important differential diagnostic consideration, mainly based on the presence of multiple or deeply located mitotic figures, especially in adult patients.
  • We therefore conclude that HRAS mutation analysis may be a useful diagnostic tool to help differentiate between Spitz nevus and Spitzoid melanoma, thereby reducing the frequency of overdiagnosis of melanoma, and to help predict the biological behavior of a STUMP.
  • [MeSH-major] Mutation. Nevus, Epithelioid and Spindle Cell / pathology. Proto-Oncogene Proteins p21(ras) / genetics. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Child. DNA, Neoplasm / analysis. Dermis / pathology. Diagnosis, Differential. Female. Humans. Male. Melanoma / diagnosis. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20871217.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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11. Smit NP, van Nieuwpoort FA, Marrot L, Out C, Poorthuis B, van Pelt H, Meunier JR, Pavel S: Increased melanogenesis is a risk factor for oxidative DNA damage--study on cultured melanocytes and atypical nevus cells. Photochem Photobiol; 2008 May-Jun;84(3):550-5
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  • [Title] Increased melanogenesis is a risk factor for oxidative DNA damage--study on cultured melanocytes and atypical nevus cells.
  • Clinical atypical (dysplastic) nevi (DN) regularly contain more melanin than do normal melanocytes (MC).
  • [MeSH-major] DNA Damage. Dysplastic Nevus Syndrome / pathology. Melanins / biosynthesis. Melanocytes / radiation effects. Reactive Oxygen Species / metabolism. Ultraviolet Rays / adverse effects
  • [MeSH-minor] Cells, Cultured. Humans. Oxidative Stress / radiation effects. Pigmentation. Risk Factors. Skin / cytology

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  • (PMID = 18435613.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins; 0 / Reactive Oxygen Species
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12. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Melanoma associated with a dysplastic nevus: report of two cases with unusual sebocyte-like melanocytes in the nevus part of the lesion. Am J Dermatopathol; 2007 Dec;29(6):566-7
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  • [Title] Melanoma associated with a dysplastic nevus: report of two cases with unusual sebocyte-like melanocytes in the nevus part of the lesion.
  • We present two cases of melanoma arising in a dysplastic nevus that contained intradermal sebocyte-like melanocytes characterized by a scalloped dark-staining nucleus surrounded by the pale multivacuolated cytoplasm imitating sebaceous differentiation.
  • Microscopically, both cases had the following features in common: the melanoma in situ, which was of the superficially spreading type, was associated with a dysplastic compound nevus, in which the sebocyte-like cells were identified in the intradermal nevus part of the lesion.
  • The sebocyte-like cells comprised a minor component but were immediately recognizable and appeared as cells with multivacuolated neoplasm and scalloped nuclei arranged in nests.
  • The conventional part of the nevi demonstrated the same phenotype, with the exception of the melanocytic nests located at the dermoepidermal junction that were HMB-45 positive.
  • [MeSH-major] Dysplastic Nevus Syndrome / pathology. Melanocytes / pathology. Melanoma / pathology. Sebum / cytology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Female. Humans. MART-1 Antigen. Middle Aged. Neoplasm Proteins / metabolism. Neoplasms, Multiple Primary. S100 Proteins / metabolism

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  • (PMID = 18032954.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Proteins
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13. Morris C, Wood P, Griffiths SL, Wilson KS, Ashton AW: MOLE: a data management application based on a protein production data model. Proteins; 2005 Feb 1;58(2):285-9
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  • [Title] MOLE: a data management application based on a protein production data model.
  • MOLE (mining, organizing, and logging experiments) has been developed to meet the growing data management and target tracking needs of molecular biologists and protein crystallographers.
  • To achieve this, MOLE is based on the data model for protein production devised at the European Bioinformatics Institute (Pajon A, et al., Proteins in press).

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  • [Copyright] (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15468326.001).
  • [ISSN] 1097-0134
  • [Journal-full-title] Proteins
  • [ISO-abbreviation] Proteins
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Martinez-Peñuela A, Del Olmo J, Boán JF, Idoate MA: Incidental findings in negative sentinel lymph nodes of patients with malignant melanoma: report of three cases. Am J Dermatopathol; 2007 Feb;29(1):104-5
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  • [Title] Incidental findings in negative sentinel lymph nodes of patients with malignant melanoma: report of three cases.
  • We present three cases of benign SLN that were clinically suspicious for involvement by metastatic melanoma and where found to be involved with other diseases or deposits previously unknown.
  • [MeSH-major] Incidental Findings. Melanoma / diagnosis. Sentinel Lymph Node Biopsy. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm. Female. Granuloma / pathology. Humans. Lymphatic Metastasis. Macrophages / metabolism. Macrophages / pathology. Male. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. S100 Proteins / metabolism. Silicones / adverse effects. Tattooing / adverse effects

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  • (PMID = 17284974.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; 0 / Silicones
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15. Tanese K, Wakabayashi A, Suzuki T, Miyakawa S: Immunoexpression of human epidermal growth factor receptor-2 in apocrine carcinoma arising in naevus sebaceous, case report. J Eur Acad Dermatol Venereol; 2010 Mar;24(3):360-2
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  • [Title] Immunoexpression of human epidermal growth factor receptor-2 in apocrine carcinoma arising in naevus sebaceous, case report.
  • [MeSH-major] Carcinoma / immunology. Neoplasms, Multiple Primary / immunology. Nevus, Sebaceous of Jadassohn / immunology. Receptor, ErbB-2 / biosynthesis. Skin Neoplasms / immunology. Sweat Gland Neoplasms / immunology

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  • (PMID = 19703100.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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16. Rosenbusch B: Co-existence of a diploid hydatidiform mole and a normal fetus: mysterious events at the pronuclear stage. Hum Reprod; 2008 Dec;23(12):2876-7
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  • [Title] Co-existence of a diploid hydatidiform mole and a normal fetus: mysterious events at the pronuclear stage.
  • [MeSH-minor] Diseases in Twins / genetics. Female. Humans. Hydatidiform Mole / genetics. Male. Models, Genetic. Pregnancy. Zygote / physiology

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  • [CommentOn] Hum Reprod. 2008 Sep;23(9):2031-5 [18556678.001]
  • (PMID = 18927128.001).
  • [ISSN] 1460-2350
  • [Journal-full-title] Human reproduction (Oxford, England)
  • [ISO-abbreviation] Hum. Reprod.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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17. Coras B, Landthaler M, Stolz W, Vogt T: Dysplastic melanocytic nevi of the lower leg: sex- and site-specific histopathology. Am J Dermatopathol; 2010 Aug;32(6):599-602
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  • [Title] Dysplastic melanocytic nevi of the lower leg: sex- and site-specific histopathology.
  • Site-specific histopathology features have been reported for acral, auricular, flexural, and genital melanocytic nevi, however, to the best of our knowledge, site- and sex-specific histology of dysplastic nevi on the lower leg (between knee and ankle) of women (DN-LW) has not been reported.
  • In this retrospective histopathology study, we compared DN-LW (N = 42) with appropriate control groups of (1) DN of the lower leg of men (N = 20; DN-LM), (2) DN from the back of women (N = 20), (3) common nevi of the lower leg of women (N = 40), and (4) levels 1-2 superficial spreading melanoma of the lower leg of women (N = 20).
  • Compared with dysplastic nevi on the back, DN-LW were smaller in diameter and exhibited a significantly higher score for pagetoid spread (P < 0.05).
  • DN-LW compared with DN-LM showed sex-specific differences with (1) pagetoid spread (P < 0.05), (2) cytologic atypia (P < 0.05), (3) presence of large melanocytes (P < 0.05), and (4) band-like pigmentation in the dermis underlying the nevus (54% in DN-LW vs. 15% in DN-LM).
  • As with other body sites, the dermatopathologist should be aware that dysplastic nevi occurring on the lower leg in women have site- and sex-specific features.
  • Knowing this profile may lower the risk of misdiagnosing DN-LW and melanoma of the lower leg of women.
  • [MeSH-major] Diagnostic Errors / prevention & control. Dysplastic Nevus Syndrome / diagnosis. Melanocytes / pathology. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Back. Diagnosis, Differential. Female. Humans. Leg. Male. Melanoma / diagnosis. Middle Aged. Retrospective Studies. Sex Factors. Young Adult

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  • [CommentIn] Am J Dermatopathol. 2012 Dec;34(8):853-5 [22481498.001]
  • (PMID = 20534984.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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18. Chen CY, Jafvert CT: Sorption of Buckminsterfullerene (C60) to saturated soils. Environ Sci Technol; 2009 Oct 1;43(19):7370-5
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  • Because C60 is extremely hydrophobic, in this study the distribution between soil and mixtures of ethanol (EOH) and water were measured at ethanol mole fractions ranging from X(EOH) = 1.0-0.4 for two soils.

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  • (PMID = 19848148.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fullerenes; 0 / Soil; 0 / Soil Pollutants; 059QF0KO0R / Water; NP9U26B839 / fullerene C60
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19. Hoch LB, Mack EJ, Hydutsky BW, Hershman JM, Skluzacek JM, Mallouk TE: Carbothermal synthesis of carbon-supported nanoscale zero-valent iron particles for the remediation of hexavalent chromium. Environ Sci Technol; 2008 Apr 1;42(7):2600-5
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  • At a 10:3 Fe/Cr mole ratio, C-Fe0 reduced a 10 ppm Cr(VI) solution to approximately 1 ppm within three days.

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  • (PMID = 18505003.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0R0008Q3JB / Chromium; 7440-44-0 / Carbon; E1UOL152H7 / Iron
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20. Rodríguez G, González R, Gonzalez D, Granados C, Pinto R, Herrera H, Gutiérrez LF, Hernández E, López F, Gómez Y: [Active search for leprosy and other skin diseases in school children from Agua de Dios, Colombia]. Rev Salud Publica (Bogota); 2007 Jul-Sep;9(3):430-8
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  • [Title] [Active search for leprosy and other skin diseases in school children from Agua de Dios, Colombia].
  • OBJECTIVE: Actively searching for leprosy, other skin diseases and BCG vaccination scars amongst school children from Agua de Dios, the municipality having the highest prevalence of leprosy in Colombia.
  • Skin smear tests and skin biopsies were performed when the clinical findings suggested leprosy.
  • RESULTS: 86 % of the 2 844 school children were examined; 833 had skin diseases and 16 % of these required evaluation by specialists.
  • Pediculosis capitis, pityriasis alba, tinea versicolor, hypopigmented nevus, insect bites and miliaria were frequently detected.
  • [MeSH-major] Leprosy / epidemiology. Mass Screening / methods. Skin Diseases / epidemiology. Students / statistics & numerical data

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  • (PMID = 18026607.001).
  • [ISSN] 0124-0064
  • [Journal-full-title] Revista de salud pública (Bogotá, Colombia)
  • [ISO-abbreviation] Rev Salud Publica (Bogota)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Colombia
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21. Lode HM, Deeg KH, Krauss J: Spinal sonography in infants with cutaneous birth markers in the lumbo-sacral region--an important sign of occult spinal dysrhaphism and tethered cord. Ultraschall Med; 2008 Dec;29 Suppl 5:281-8
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  • The following cutaneous markers could be found: Asymmetrical gluteal crease (4); dermal sinus (2), hairy tuft (1); pigmented naevus (1); cutaneous appendage (1); haemangioma (1); unilateral peroneal paralysis with hypotrophic correspondic leg (1).

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  • (PMID = 17610175.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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22. Blanchard-Fillion B, Prou D, Polydoro M, Spielberg D, Tsika E, Wang Z, Hazen SL, Koval M, Przedborski S, Ischiropoulos H: Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. J Neurosci; 2006 Jun 7;26(23):6124-30
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  • Intracellular levels of 133 micromol of 3-nitrotyrosine per mole of tyrosine did not alter NT2 viability but induced PC12 apoptosis.

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  • (PMID = 16763020.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG13966; United States / NHLBI NIH HHS / HL / HL076491; United States / NHLBI NIH HHS / HL / HL54926; United States / NINDS NIH HHS / NS / NS38370
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acid Transport Systems; 0 / Dopamine Plasma Membrane Transport Proteins; 0 / Nitrophenols; 0 / Phenylacetates; 0 / Tubulin; 10463-20-4 / 4-hydroxy-5-nitrophenyl acetic acid; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine; EC 1.4.3.4 / Monoamine Oxidase; EC 4.1.1.28 / Aromatic-L-Amino-Acid Decarboxylases; VTD58H1Z2X / Dopamine
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23. Behrends R, Fuchs K, Kaatze U, Hayashi Y, Feldman Y: Dielectric properties of glycerol/water mixtures at temperatures between 10 and 50 degrees C. J Chem Phys; 2006 Apr 14;124(14):144512
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  • At six temperatures T between 10 and 50 degrees C and at mole fractions x(g) of glycerol (0<x(g)<or=0.9) the complex (electric) permittivity epsilon(nu) of glycerol/water mixtures has been measured as a function of frequency nu between 1 MHz and 40 GHz.

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  • (PMID = 16626219.001).
  • [ISSN] 0021-9606
  • [Journal-full-title] The Journal of chemical physics
  • [ISO-abbreviation] J Chem Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Lutz BR, Chen J, Schwartz DT: Characterizing homogeneous chemistry using well-mixed microeddies. Anal Chem; 2006 Mar 1;78(5):1606-12
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  • A simple algebraic mole balance is combined with Raman spectroscopy measurements of oxidant concentration in the eddy and bulk to determine the reaction rate law and homogeneous rate constant (45 +/- 9 M(-1) s(-1)) for the antioxidant properties of vitamin C against ferricyanide.

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  • (PMID = 16503613.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Sutton VR, Hopkins BJ, Eble TN, Gambhir N, Lewis RA, Van den Veyver IB: Facial and physical features of Aicardi syndrome: infants to teenagers. Am J Med Genet A; 2005 Oct 15;138A(3):254-8
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  • Aicardi syndrome is a sporadic disorder that affects primarily females and is hypothesized to be caused by heterozygous mutations in an X-linked gene.
  • Various skin lesions (including multiple nevi, skin tags, hemangiomas, one giant melanotic nevus, and a history of a previously removed angiosarcoma) were present in 8/40 (20%).


26. Barbara KA, Buss EA: Integration of insect parasitic nematodes (Rhabditida steinernematidae) with insecticides for control of pest mole crickets (Orthoptera: Gryllotalpidae: Scapteriscus spp.). J Econ Entomol; 2005 Jun;98(3):689-93
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  • [Title] Integration of insect parasitic nematodes (Rhabditida steinernematidae) with insecticides for control of pest mole crickets (Orthoptera: Gryllotalpidae: Scapteriscus spp.).
  • To develop a successful integrated pest management program for pest mole crickets (Orthoptera: Gryllotalpidae: Scapteriscus spp.
  • Aqueous solutions of five pesticides (acephate, bifenthrin, deltamethrin, fipronil, and imidacloprid) used in turfgrass to control mole crickets were tested for compatibility with Steinernema scapterisci Nguyen & Smart (Rhabditida: Steinernematidae) in the laboratory.

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  • (PMID = 16022294.001).
  • [ISSN] 0022-0493
  • [Journal-full-title] Journal of economic entomology
  • [ISO-abbreviation] J. Econ. Entomol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insecticides; 0 / Solutions
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27. Jang M, Min SH, Park JK, Tlachac EJ: Hydrous ferric oxide incorporated diatomite for remediation of arsenic contaminated groundwater. Environ Sci Technol; 2007 May 1;41(9):3322-8
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  • Based on these proportions of arsenic species and the initial As-to-Fe molar ratio (0.15 molAs mole(-1)), batch kinetic tests revealed that the sorption density (0.076 molAs molFe(-1)) for Fe (25%)-diatomite seems to be less than the expected value (0.086 molAs molFe(-1) calculated from the sorption density data reported by Lafferty and Loeppert (Environ. Sci. Technol.

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  • (PMID = 17539544.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Humic Substances; 0 / Water Pollutants, Chemical; 61790-53-2 / Diatomaceous Earth; 68855-54-9 / diatomite; 7440-44-0 / Carbon; E1UOL152H7 / Iron; N712M78A8G / Arsenic
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28. Hori H, Nagaoka Y, Yamamoto A, Sano T, Yamashita N, Taniyasu S, Kutsuna S, Osaka I, Arakawa R: Efficient decomposition of environmentally persistent perfluorooctanesulfonate and related fluorochemicals using zerovalent iron in subcritical water. Environ Sci Technol; 2006 Feb 1;40(3):1049-54
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  • Use of iron led to the most efficient PFOS decomposition: When iron powder was added to an aqueous solution of PFOS (93-372 microM) and the mixture was heated at 350 degrees C for 6 h, PFOS concentration in the reaction solution fell below 2.2 microM (detection limit of HPLC with conductometric detection), with formation of F-ions with yields [i.e., (moles of F- formed)/(moles of fluorine content in initial PFOS) x 100] of 46.2-51.4% and without any formation of perfluorocarboxylic acids.
  • A small amount of CHF3 was detected in the gas phase with a yield [i.e., (moles of CHF3)/(moles of carbon content in initial PFOS) x 100] of 0.7%, after the reaction of PFOS (372 microM) with iron at 350 degree C for 6 h.

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  • (PMID = 16509356.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkanesulfonic Acids; 0 / Environmental Pollutants; 0 / Fluorocarbons; 059QF0KO0R / Water; 1763-23-1 / perfluorooctane sulfonic acid; E1UOL152H7 / Iron
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29. Kahn MA, Weathers DR, Hoffman JG: Transformation of a benign oral pigmentation to primary oral melanoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Oct;100(4):454-9
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  • [Title] Transformation of a benign oral pigmentation to primary oral melanoma.
  • OBJECTIVE: The objective is to report the serendipitous 7-year follow-up and transformation of a melanotic palatal lesion, which was initially diagnosed histologically as a benign oral melanotic macule, into primary oral melanoma and to provide long-term follow-up of a case of oral malignant melanoma.
  • STUDY DESIGN: Nine formalin-fixed paraffin-embedded tissue blocks from several different facilities and microscopic slides of the patient's lesions were reviewed to study the transformation of a benign, oral, pigmented lesion into melanoma.
  • RESULTS: Review of blocks and slides of the patient's lesions suggest that the onset of melanocytic hyperplasia (increased clear cell activity) heralded the transformation of the melanotic macule into melanoma.
  • The histology of the first biopsies was totally benign, but retrospectively, the clinical appearance was not typical and was somewhat worrisome because of the size of the lesion and feathering of the pigmentation at the periphery.
  • CONCLUSIONS: This study documents a case of primary oral melanoma arising from an apparent oral melanotic macule and suggests that even histologically benign-appearing oral melanotic lesions should perhaps be viewed with caution if increased numbers of melanocytes (melanocytic hyperplasia or clear cell activity) are present.
  • [MeSH-major] Melanoma / pathology. Melanosis / pathology. Mouth Neoplasms / pathology

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  • (PMID = 16182166.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Mehnert JM, McCarthy MM, Jilaveanu L, Flaherty KT, Aziz S, Camp RL, Rimm DL, Kluger HM: Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays. Hum Pathol; 2010 Mar;41(3):375-84
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  • [Title] Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays.
  • Angiogenesis is required for progression and metastasis of melanoma.
  • Analysis of angiogenic molecules in benign and malignant tissues may allow identification of markers useful for prediction of sensitivity to antiangiogenic agents.
  • We hypothesized that differential expression of vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, VEGF-R2, and VEGF-R3 would be higher in melanomas than nevi and higher in advanced melanoma.
  • Using automated quantitative analysis, we quantified VEGF, -R1, -R2 and -R3 expression in melanoma tissue microarrays composed of 540 nevi and 468 melanoma specimens (198 primaries, 270 metastases).
  • VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 expression was significantly higher in melanomas than nevi by unpaired t tests (P < .0001).
  • VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 expression is higher in melanomas than nevi.
  • Higher expression of VEGF-R2 was found in metastases versus primaries, supporting the idea that selection for an angiogenic phenotype in metastatic melanoma is conferred via up-regulation of VEGF-R2.
  • Clinical trials using antiangiogenic agents in melanoma should include correlative assays of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 as biomarkers of response to therapy, preferably using quantitative methods such as automated quantitative analysis.
  • Such assessments could assist with evaluation of these molecules as therapeutic targets in melanoma, ultimately facilitating improved selection of patients for treatment.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20004943.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115756-04; United States / NCI NIH HHS / CA / R01 CA115756; United States / NCI NIH HHS / CA / CA115756-01; United States / NCI NIH HHS / CA / R01 CA115756-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
  • [Other-IDs] NLM/ NIHMS142667; NLM/ PMC2824079
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31. Wietfeldt ED, Thiele J: Malignancies of the anal margin and perianal skin. Clin Colon Rectal Surg; 2009 May;22(2):127-35
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  • [Title] Malignancies of the anal margin and perianal skin.
  • Malignancies of the anal margin and perianal skin are relatively uncommon lesions, comprising 3 to 4% of all anorectal malignancies.
  • Commonly included in this group of cancers are Bowen's disease (intraepithelial squamous cell cancer), perianal Paget's disease (intraepithelial adenocarcinoma), invasive squamous cell cancer, basal cell cancer, and malignant melanoma.
  • Buschke-Lowenstein tumor, or giant condyloma acuminatum, is not always included because this lesion is technically benign, although it displays aggressive local invasive behavior that makes it difficult to manage.
  • Invasion and metastasis are relatively rare in this group of neoplasms; perianal Paget's disease has the highest risk of associated underlying neoplasm.

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  • (PMID = 20436838.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780245
  • [Keywords] NOTNLM ; Anal margin cancer / diagnosis / local excision / radiation therapy / treatment options
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32. Alés-Fernández M, Ríos-Martín JJ, Camacho-Martínez FM: Localized argyria secondary to acupuncture mimicking blue nevus. J Drugs Dermatol; 2010 Aug;9(8):1019-20
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  • [Title] Localized argyria secondary to acupuncture mimicking blue nevus.
  • The lesions often are clinically indistinguishable from blue nevi and metastatic melanoma.
  • [MeSH-major] Acupuncture Therapy / adverse effects. Argyria / etiology. Nevus, Blue / diagnosis

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  • (PMID = 20684156.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Burns JM, Craig PS, Shaw TJ, Ferry JL: Multivariate examination of Fe(II)/Fe(III) cycling and consequent hydroxyl radical generation. Environ Sci Technol; 2010 Oct 1;44(19):7226-31
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  • Through the range of experimental conditions of this design, the ratio of the number of moles of HO• produced to the number of moles of Fe(II) consumed varied from 3 to 750, corresponding to approximately 10 to 2200 Fe(II)/Fe(III) cycles, respectively.

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  • (PMID = 20469853.001).
  • [ISSN] 1520-5851
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ferric Compounds; 0 / Ferrous Compounds; 0 / Free Radical Scavengers; 3352-57-6 / Hydroxyl Radical
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34. Hata S, Hamada J, Maeda K, Murai T, Tada M, Furukawa H, Tsutsumida A, Saito A, Yamamoto Y, Moriuchi T: PAX4 has the potential to function as a tumor suppressor in human melanoma. Int J Oncol; 2008 Nov;33(5):1065-71
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  • [Title] PAX4 has the potential to function as a tumor suppressor in human melanoma.
  • In this study, we first quantified expression of 9 PAX genes in human nevus pigmentosus tissues, melanoma tissues and melanoma cell lines by the real-time reverse transcription-PCR method.
  • As a result, we found that the expression levels of PAX4 and PAX9 were extremely low in melanoma tissues and cell lines compared to nevus pigmentosus tissues.
  • We then established melanoma cells overexpressing PAX4 and examined roles of PAX4 in cell growth.
  • PAX4-overexpression reduced in vitro cell growth of human melanoma C8161 and MeWo cells.
  • Furthermore, treatment of C8161 and MeWo cells with 5-azacytidine, a DNA demethylating agent, induced the expression of PAX4, suggesting that DNA methylation repressed the PAX4 gene expression in human melanoma.
  • [MeSH-major] Homeodomain Proteins / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. Paired Box Transcription Factors / metabolism. Skin Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 18949370.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Homeodomain Proteins; 0 / PAX4 protein, human; 0 / Paired Box Transcription Factors; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins; M801H13NRU / Azacitidine
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35. Namani T, Deamer DW: Stability of model membranes in extreme environments. Orig Life Evol Biosph; 2008 Aug;38(4):329-41
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  • Vesicles formed by mixtures of decylamine and decanoic acid (1:1 mole ratio) are relatively permeable to pyranine, a fluorescent anionic dye, but permeability could be reduced by adding 2 mol% of a polycyclic aromatic hydrocarbon such as pyrene.
  • For instance, 1:1 mole ratio mixtures of dodecylamine and dodecanoic acid were able to retain pyranine dye during and following gel filtration.

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  • (PMID = 18560991.001).
  • [ISSN] 0169-6149
  • [Journal-full-title] Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life
  • [ISO-abbreviation] Orig Life Evol Biosph
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amines; 0 / Cations; 0 / Fatty Acids; 0 / Fluorescent Dyes; 0 / Lauric Acids; 1160N9NU9U / lauric acid; E1UOL152H7 / Iron; I38ZP9992A / Magnesium; SY7Q814VUP / Calcium; YWY9OD6A2K / dodecylamine
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36. Samaratunga SS, Nishimoto J, Tabata M: Toluene/ter-butanol mixed solvent for the selective extraction of Cr(VI) from divalent heavy metals. Anal Sci; 2005 Sep;21(9):1073-8
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  • Chromium(VI) was selectively extracted as a solvated ion-pair of [ter-BuOH2+ x CrO3Cl-] at ter-BuOH mole fractions of between 0.1 and 0.6 (9.0-57.2% in volume).
  • Divalent metals were extracted at ter-BuOH mole fraction over 0.6 with extraction percents of Co (< 20%), Cu (< 15%), Ni (< 10%) and Zn (< 20%).

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  • (PMID = 16363476.001).
  • [ISSN] 0910-6340
  • [Journal-full-title] Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • [ISO-abbreviation] Anal Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cadmium Compounds; 0 / Carcinogens, Environmental; 0 / Cations, Divalent; 0 / Saline Solution, Hypertonic; 0 / Solutions; 0 / Solvents; 059QF0KO0R / Water; 0R0008Q3JB / Chromium; 18540-29-9 / chromium hexavalent ion; 3FPU23BG52 / Toluene; 3G0H8C9362 / Cobalt; 789U1901C5 / Copper; 7OV03QG267 / Nickel; J41CSQ7QDS / Zinc; M4I0D6VV5M / Calcium Chloride; MD83SFE959 / tert-Butyl Alcohol
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37. Martinez-Garcia JC, Tamarit JL, Capaccioli S, Barrio M, Veglio N, Pardo LC: Alpha-relaxation dynamics of orientanionally disordered mixed crystals composed of Cl-adamantane and CN-adamantane. J Chem Phys; 2010 Apr 28;132(16):164516
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  • The characteristic relaxation times are analyzed as a function of temperature and mole fraction.
  • By setting a common temporal origin ("isochronal origin") at tau(T(g)) = 100 s for each mole fraction, it emerges that the substitution of ClA molecules by those of CNA (diminution of X) gives rise to a slow down in the dynamics, despite that the molecular volume of ClA molecules are smaller than those of CNA.
  • It is also shown that the heterogeneities produced by the concentration fluctuations due to the chemical disorder are the main contribution to the non-exponential character of the alpha-relaxation peaks.

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  • (PMID = 20441297.001).
  • [ISSN] 1089-7690
  • [Journal-full-title] The Journal of chemical physics
  • [ISO-abbreviation] J Chem Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Ha L, Merlino G, Sviderskaya EV: Melanomagenesis: overcoming the barrier of melanocyte senescence. Cell Cycle; 2008 Jul 1;7(13):1944-8
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  • Although melanoma ultimately progresses to a highly aggressive and metastatic disease that is typically resistant to currently available therapy, it often begins as a benign nevus consisting of a clonal population of hyperplastic melanocytes that cannot progress because they are locked in a state of cellular senescence.
  • Once senescence is overcome, the nevus can exhibit dysplastic features and readily progress to more lethal stages.
  • Recent advances have convincingly demonstrated that senescence represents a true barrier to the progression of many types of cancer, including melanoma.
  • Thus, understanding the mechanism(s) by which melanoma evades senescence has become a priority in the melanoma research community.

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  • (PMID = 18604170.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / Z01 BC008756-20; United Kingdom / Wellcome Trust / / 078327
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53; EC 2.7.7.49 / Telomerase; EC 3.6.5.2 / ADP-Ribosylation Factors; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 65
  • [Other-IDs] NLM/ NIHMS104222; NLM/ PMC2678050
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39. Hoskins C, Ouaissi M, Lima SC, Cheng WP, Loureirio I, Mas E, Lombardo D, Cordeiro-da-Silva A, Ouaissi A, Kong Thoo Lin P: In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. Pharm Res; 2010 Dec;27(12):2694-703
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  • PURPOSE: To evaluate the in vitro and in vivo pancreatic anticancer activity of a nano-sized formulation based on novel polyallylamine grafted with 5% mole cholesteryl pendant groups (CH(5)-PAA).

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  • (PMID = 20872054.001).
  • [ISSN] 1573-904X
  • [Journal-full-title] Pharmaceutical research
  • [ISO-abbreviation] Pharm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Nie L, Zhu J, Gratton MA, Liao A, Mu KJ, Nonner W, Richardson GP, Yamoah EN: Molecular identity and functional properties of a novel T-type Ca2+ channel cloned from the sensory epithelia of the mouse inner ear. J Neurophysiol; 2008 Oct;100(4):2287-99
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  • However, unlike most multiion channels, the T-type channel does not exhibit the anomalous mole fraction effect, possibly reflecting comparable permeation properties of divalent cations.

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  • (PMID = 18753322.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC-003826; United States / NIDCD NIH HHS / DC / DC-006442
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cacna1g protein, mouse; 0 / Calcium Channels, T-Type; 0 / DNA, Complementary
  • [Other-IDs] NLM/ PMC2576198
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41. Babushkina OB, Ekres S, Nauer GE: Raman spectroscopy of the mixtures (x)1-butyl-1-methylpyrrolidinium chloride-(1 - x)TaCl5 in solid and molten states. J Phys Chem A; 2008 Sep 11;112(36):8288-94
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  • The formation of oxochloride species of tantalum(V) was investigated in mixtures of Pyr14Cl-TaCl5-Na2O (x = 0.65) at various O/Ta mole ratios, and the formation of the oligomeric species with Ta-O-Ta bridging bonds was determined.

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  • (PMID = 18707058.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Lan BY, Nigmatullin R, Li Puma G: Ozonation kinetics of cork-processing water in a bubble column reactor. Water Res; 2008 May;42(10-11):2473-82
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  • The ozonation of cork-processing water in the bubble column was analysed in terms of a mole balance coupled with ozonation kinetics modelled by the two-film theory of mass transfer and chemical reaction.

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  • (PMID = 18342905.001).
  • [ISSN] 0043-1354
  • [Journal-full-title] Water research
  • [ISO-abbreviation] Water Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Industrial Waste; 66H7ZZK23N / Ozone; S88TT14065 / Oxygen
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43. Kamitakahara M, Kawashita M, Miyata N, Kokubo T, Nakamura T: Preparation of bioactive flexible poly(tetramethylene oxide) (PTMO)-CaO-Ta2O5 hybrids. J Mater Sci Mater Med; 2007 Jun;18(6):1117-24
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  • In the system PTMO-CaO-Ta2O5, the Si-PTMO/Ta(OEt)5 weight ratio was 40/60 and CaCl2/Ta(OEt)5 mole ratios were 0.05, 0.10 and 0.15 (hybrids PT40Ca5, PT40Ca10 and PT40Ca15, respectively).

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  • (PMID = 17268865.001).
  • [ISSN] 0957-4530
  • [Journal-full-title] Journal of materials science. Materials in medicine
  • [ISO-abbreviation] J Mater Sci Mater Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apatites; 0 / Biocompatible Materials; 0 / Calcium Compounds; 0 / Gels; 0 / Oxides; 0 / Solutions; 0 / polytetramethyloxide; 59763-75-6 / tantalum oxide; 6424HBN274 / Tantalum; C7X2M0VVNH / lime
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44. Schechter I, Ziv E: Inhibitors can activate proteases to catalyze the synthesis and hydrolysis of peptides. Biochemistry; 2006 Dec 12;45(49):14567-72
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  • One mole of the inhibitor could catalyze rapid hydrolysis of at least 53 mol of substrate.

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  • (PMID = 17144650.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dipeptides; 0 / Peptides; 0 / Protease Inhibitors; EC 3.4.- / Peptide Hydrolases; EC 3.4.21.4 / Trypsin; EC 3.4.22.2 / Papain
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45. Tolocka MP, Heaton KJ, Dreyfus MA, Wang S, Zordan CA, Saul TD, Johnston MV: Chemistry of particle inception and growth during alpha-pinene ozonolysis. Environ Sci Technol; 2006 Mar 15;40(6):1843-8
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  • The carbon-to-oxygen mole ratios of suspected nucleating agents are in the range of 2.25-4.0, while the measured ratios are from 1.9 for 9 nm particles to 2.5 and 2.7 for 30 and 50 nm particles, respectively.

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  • (PMID = 16570606.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aerosols; 0 / Air Pollutants; 0 / Monoterpenes; 0 / Oxidants, Photochemical; 059QF0KO0R / Water; 66H7ZZK23N / Ozone; 7440-44-0 / Carbon; JPF3YI7O34 / alpha-pinene; S88TT14065 / Oxygen
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46. Sizgek GD, Sizgek E, Griffith CS, Luca V: Mesoporous zirconium titanium oxides. Part 2: Synthesis, porosity, and adsorption properties of beads. Langmuir; 2008 Nov 4;24(21):12323-30
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  • Mesoporous zirconium titanium mixed-oxide beads having disordered wormhole textures and mole fractions of Zr (x) ranging from x=0.25 to 0.67 have been prepared.
  • The specific surface areas of the beads were linked to the Zr mole fraction in the precursor solution and were generally greater than 350 m2/g for x=0.5.

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  • (PMID = 18828618.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Thomas L, Dalle S: Dermoscopy provides useful information for the management of melanonychia striata. Dermatol Ther; 2007 Jan-Feb;20(1):3-10
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  • In the case of brown longitudinal pigmentation with parallel regular lines, the diagnosis of nail apparatus melanocytic nevus could be made.
  • On the other hand, the presence of a brown pigmentation overlaid by longitudinal lines irregular in their thickness, spacing, color, or parallelism is highly in favor of a melanoma.
  • [MeSH-minor] Dermoscopy. Diagnosis, Differential. Humans. Melanoma / diagnosis. Melanoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 17403255.001).
  • [ISSN] 1396-0296
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 14
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48. Reynolds F, Weissleder R, Josephson L: Protamine as an efficient membrane-translocating peptide. Bioconjug Chem; 2005 Sep-Oct;16(5):1240-5
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  • Protamine, a mixture of positively charged proteins from salmon roe used in diverse pharmaceutical applications, was reacted with the N-hydroxysuccinimide ester of tetramethylrhodamine to yield tetramethylrhodamine-labeled protamines (Pro(Rh)) containing one mole of fluorochrome per mole of protein.

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  • (PMID = 16173804.001).
  • [ISSN] 1043-1802
  • [Journal-full-title] Bioconjugate chemistry
  • [ISO-abbreviation] Bioconjug. Chem.
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB004626; United States / NIBIB NIH HHS / EB / R01-EB00662
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fish Proteins; 0 / Gene Products, tat; 0 / Peptide Fragments; 0 / Protamines; 0 / Rhodamines; TPY09G7XIR / Fluorescein
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49. Manosca F, Schinstine M, Fetsch PA, Sorbara L, Maria Wilder A, Brosky K, Erickson D, Raffeld M, Filie AC, Abati A: Diagnostic effects of prolonged storage on fresh effusion samples. Diagn Cytopathol; 2007 Jan;35(1):6-11
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  • We sought to determine if effusion specimens are suitable for morphologic, immunocytochemical, and DNA-based molecular studies after prolonged periods of refrigerated storage time.
  • Specimens evaluated included four pleural (3 benign, 1 breast adenocarcinoma) and six peritoneal (2 ovarian adenocarcinomas, 1 malignant melanoma, 2 mesotheliomas, 1 atypical mesothelial) effusions.
  • [MeSH-minor] Adult. Biomarkers, Tumor. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. Time Factors

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  • (PMID = 17173298.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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50. Takeda H, Ikenaga S, Kaneko T, Nakajima K, Harada K, Hanada K, Sawamura D: Proliferating trichilemmal tumor developing in nevus sebaceous. Eur J Dermatol; 2010 Sep-Oct;20(5):664-5
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  • [Title] Proliferating trichilemmal tumor developing in nevus sebaceous.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Nevus, Sebaceous of Jadassohn / pathology. Scalp. Skin Neoplasms / pathology

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  • (PMID = 20627855.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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51. Kacerovska D, Michal M, Kazakov DV: Sebocyte-like melanocytes in desmoplastic blue nevus. Am J Dermatopathol; 2008 Oct;30(5):509-10
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  • [Title] Sebocyte-like melanocytes in desmoplastic blue nevus.
  • [MeSH-major] Melanocytes / pathology. Nevus, Blue / pathology. Skin Neoplasms / pathology

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  • (PMID = 18806502.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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52. Zubidat AE, Nelson RJ, Haim A: Photoentrainment in blind and sighted rodent species: responses to photophase light with different wavelengths. J Exp Biol; 2010 Dec 15;213(Pt 24):4213-22
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  • Social voles (Microtus socialis) and 'blind' mole rats (Spalax ehrenbergi) were exposed to short-wavelength (479 nm) or long-wavelength (697 nm) light at an intensity of 293 μW cm(-2).

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  • (PMID = 21113002.001).
  • [ISSN] 1477-9145
  • [Journal-full-title] The Journal of experimental biology
  • [ISO-abbreviation] J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 2208-40-4 / 6-sulfatoxymelatonin; JL5DK93RCL / Melatonin; WI4X0X7BPJ / Hydrocortisone; YKH834O4BH / Epinephrine
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53. Jain JP, Kumar N: Self assembly of amphiphilic (PEG)(3)-PLA copolymer as polymersomes: preparation, characterization, and their evaluation as drug carrier. Biomacromolecules; 2010 Apr 12;11(4):1027-35
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  • For this, three chains of methoxy-PEG(1100) were directly attached to citric acid by esterification. (Methoxy-PEG(1100))(3)-citrate was then reacted at its hydroxyl terminal with different moles of d,l-lactide by ring-opening polymerization to obtain polymers with five different PEG-to-PLA ratios ranging from 10:90 to 90:10.

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  • (PMID = 20178378.001).
  • [ISSN] 1526-4602
  • [Journal-full-title] Biomacromolecules
  • [ISO-abbreviation] Biomacromolecules
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Carriers; 0 / Polymers; 0 / monomethoxypolyethyleneglycol-polylactide block copolymer; 30IQX730WE / Polyethylene Glycols
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54. Kacerovska D, Sima R, Michal M, Hes O, Roucka P, Zarybnicka M, Hora M, Chudacek Z, Kazakov DV: Carney complex: a clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene. J Am Acad Dermatol; 2009 Jul;61(1):80-7
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  • BACKGROUND: Carney complex (CNC) is an autosomal dominant disorder associated with multiple neoplasms.
  • Additionally, a blue nevus, a lipoma, multiple calcifications in both testes, and hypoechogenic areas suspected of being adenomas in the thyroid gland were found.
  • [MeSH-major] Cyclic AMP-Dependent Protein Kinase RIalpha Subunit / genetics. Endocrine Gland Neoplasms / genetics. Heart Neoplasms / genetics. Myxoma / genetics. Pigmentation Disorders / genetics. Skin Neoplasms / genetics

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  • (PMID = 19539840.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / PRKAR1A protein, human
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55. Domańska U, Pobudkowska A, Pelczarska A, Gierycz P: pKa and solubility of drugs in water, ethanol, and 1-octanol. J Phys Chem B; 2009 Jul 2;113(26):8941-7
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  • The equilibrium mole fraction solubilities of six drugs were measured in a range of temperatures from 240 to 340 K in three important solvents for drugs: water, ethanol, and 1-octanol using the dynamic method.

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  • (PMID = 19518053.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations; 0 / Solvents; 059QF0KO0R / Water; 3K9958V90M / Ethanol; NV1779205D / 1-Octanol
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56. Kim HH, Cannata JM, Liu R, Chang JH, Silverman RH, Shung KK: 20 MHz/40 MHz dual element transducers for high frequency harmonic imaging. IEEE Trans Ultrason Ferroelectr Freq Control; 2008 Dec;55(12):2683-91
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  • Images of a posterior segment of an excised pig eye and a choroidal nevus of human eye were obtained both for single element and dual element transducers and compared to demonstrate the advantages of dual element harmonic imaging.

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  • (PMID = 19126492.001).
  • [ISSN] 1525-8955
  • [Journal-full-title] IEEE transactions on ultrasonics, ferroelectrics, and frequency control
  • [ISO-abbreviation] IEEE Trans Ultrason Ferroelectr Freq Control
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / P41 EB002182; United States / NIBIB NIH HHS / EB / P41-EB002182; United States / NIBIB NIH HHS / EB / P41 EB002182-12; United States / NIBIB NIH HHS / EB / EB002182-12; United States / NIBIB NIH HHS / EB / EB00238
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oxides; 05175J654G / Niobium; 12031-63-9 / lithium niobate
  • [Other-IDs] NLM/ NIHMS130182; NLM/ PMC2717901
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57. Sabatini K, Mattila JP, Kinnunen PK: Interfacial behavior of cholesterol, ergosterol, and lanosterol in mixtures with DPPC and DMPC. Biophys J; 2008 Sep;95(5):2340-55
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  • For fluid DMPC matrix, no modulation of the monolayer phase behavior due to the sterols was evident with the exception of lanosterol, for which a pronounced discontinuity between mole fractions of X = 0.3 and X = 0.75 was discernible in the compression isotherms.

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  • (PMID = 18515391.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membranes, Artificial; 059QF0KO0R / Water; 1J05Z83K3M / Lanosterol; 2644-64-6 / 1,2-Dipalmitoylphosphatidylcholine; 97C5T2UQ7J / Cholesterol; U86ZGC74V5 / Dimyristoylphosphatidylcholine; Z30RAY509F / Ergosterol
  • [Other-IDs] NLM/ PMC2517046
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58. Lee CJ, Yang J: alpha-Cyclodextrin-modified infrared sensing system for rapidly determining the enantiomeric composition of chiral compounds. Talanta; 2008 Feb 15;74(5):1104-12
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  • A linear relationship between the analytical signals and the mole fraction of the enantiomers was obtained under conditions in which the concentration of the chiral compound was sufficiently low.

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  • (PMID = 18371757.001).
  • [ISSN] 1873-3573
  • [Journal-full-title] Talanta
  • [ISO-abbreviation] Talanta
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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59. Drunkenmölle E, Marsch WCh, Lübbe D, Helmbold P: Paratumoral epidermal hyperplasia: a novel prognostic factor in thick primary melanoma of the skin? Am J Dermatopathol; 2005 Dec;27(6):482-8
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  • [Title] Paratumoral epidermal hyperplasia: a novel prognostic factor in thick primary melanoma of the skin?
  • There is a lack of histopathological factors to sub-stratify prognosis in pT3/4 melanoma primaries.
  • In the presented pilot study, the prognostic significance of different clinical and histopathological parameters was studied in thick primary melanoma taking paratumoral epidermal hyperplasia (PTEH) into consideration.
  • Of 1632 melanoma patients in the melanoma register of the Martin Luther University Halle-Wittenberg in the years 1980 to 1987, 16 cases with tumor thickness (TT) of the primary > or = 3 mm, documented metastasis-free follow-up of 10+ years after primary therapy and available histologic sections were compared with an adequate recurrence control group (n = 62) by PTEH and standard prognostic parameters.
  • Of the standard prognostic parameters, TT, sex, location, and lack of nevus association also correlated with metastasis.
  • Occurrence of PTEH might predict a more moderate course of disease in thick melanoma.
  • Thus, it might become an easily determinable and effective tool to sub-stratify prognosis in thick primary melanoma of the skin.
  • [MeSH-major] Epidermis / pathology. Melanoma / pathology. Neoplasm Metastasis / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 16314703.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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60. Matsuda N, Katsube K, Mikami S, Katsuki Y, Iseki H, Mukai M, Yamaguchi A, Takano Y, Nakajima T, Nakajima H, Kishi K: E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro. J Dermatol Sci; 2008 Oct;52(1):21-30
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  • [Title] E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro.
  • BACKGROUND: Giant congenital nevocellular nevi (GCNN) are histologically characterized by the broad distribution of nevus cells in the epidermis and dermis.
  • RESULTS: The nevus cells in the superficial region showed the immunoreactivity of E-cadherin in a membranous pattern, but those in the deep part of dermis had little immunoreactivity.
  • Ultra-structural analysis of the superficial nevus cells revealed that E-cadherin immunodeposits in the fibrillar processes around the cell body in a spotted pattern.
  • This distribution pattern is quite different from that in the adherens junction of skin squamous epithelial cells.
  • Boyden chamber experiments were performed using primary cultures of intradermal nevus cells.
  • CONCLUSIONS: These results indicate that E-cadherin in the nevus cells may affect nevus cell motility rather than intercellular attachment.
  • [MeSH-major] Cadherins / metabolism. Cell Movement. Epidermis / metabolism. Epithelial Cells / metabolism. Nevus, Intradermal / congenital. Nevus, Intradermal / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adult. Child, Preschool. Humans. Infant. Microscopy, Immunoelectron. Skin Neoplasms / congenital. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 18502615.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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61. Henning JS, Dusza SW, Wang SQ, Marghoob AA, Rabinovitz HS, Polsky D, Kopf AW: The CASH (color, architecture, symmetry, and homogeneity) algorithm for dermoscopy. J Am Acad Dermatol; 2007 Jan;56(1):45-52
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  • Architectural order/disorder is derived from current concepts regarding the biology of benign versus malignant melanocytic neoplasms.
  • METHODS: A total CASH score (TCS) was calculated for dermoscopic images of 325 melanocytic neoplasms.
  • RESULTS: The mean TCS was 12.28 for melanoma, 7.62 for dysplastic nevi, and 5.24 for nondysplastic nevi.
  • A TCS of 8 or more yielded a sensitivity of 98% and specificity of 68% for the diagnosis of melanoma.
  • CONCLUSIONS: The CASH algorithm can distinguish melanoma from melanocytic nevi with sensitivity and specificity comparable with other algorithms.
  • [MeSH-major] Algorithms. Dermoscopy / standards. Melanoma / ultrastructure. Skin Neoplasms / ultrastructure
  • [MeSH-minor] Area Under Curve. Cross-Sectional Studies. Diagnosis, Differential. Melanocytes / ultrastructure. Nevus, Pigmented / congenital. Nevus, Pigmented / diagnosis. Nevus, Pigmented / ultrastructure. Pigmentation. Pilot Projects. Predictive Value of Tests. ROC Curve. Reproducibility of Results. Severity of Illness Index

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  • (PMID = 17190620.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
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62. Bakshi MS, Kaur G: Mixed micelles of series of monomeric and dimeric cationic, zwitterionic, and unequal twin-tail cationic surfactants with sugar surfactants: a fluorescence study. J Colloid Interface Sci; 2005 Sep 15;289(2):551-9
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  • Steady state fluorescence measurements have been carried out for binary mixtures of a series of monomeric cationic (MC), zwitterionic (ZI), dimeric cationic (DC), and twin-tail cationic (TC) surfactants with sugar (beta-C8G and beta-C12G) over the whole mole fraction range using pyrene as fluorescence probe.
  • The various micellar parameters, such as micelle mole fraction (X1), regular solution interaction parameter (beta), micropolarity, and mean micelle aggregation number (Nagg), have been determined for all these series of mixtures.

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  • (PMID = 16112236.001).
  • [ISSN] 0021-9797
  • [Journal-full-title] Journal of colloid and interface science
  • [ISO-abbreviation] J Colloid Interface Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Nzegwu MA, Waziri-Erameh MJ, Ukponmwan CU, Igbe AP: Ocular melanoma presenting as a case of panophthalmitis in a 78-year-old Nigerian woman (masquerade syndrome): an uncommon finding in Benin City, Nigeria. Eur J Cancer Care (Engl); 2007 Sep;16(5):451-2
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  • [Title] Ocular melanoma presenting as a case of panophthalmitis in a 78-year-old Nigerian woman (masquerade syndrome): an uncommon finding in Benin City, Nigeria.
  • Although some benign conditions can be considered masquerade syndromes, most often the term refers to malignant entities.
  • In this article, we present a case of a 78-year-old Nigerian woman who had an ocular melanoma that presented as a panophthalmitis, a rare case of masquerade syndrome in our environment.
  • [MeSH-major] Eye Neoplasms / complications. Melanoma / complications. Panophthalmitis / etiology

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  • (PMID = 17760933.001).
  • [ISSN] 0961-5423
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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64. Stanley RJ, Stoecker WV, Moss RH: A relative color approach to color discrimination for malignant melanoma detection in dermoscopy images. Skin Res Technol; 2007 Feb;13(1):62-72
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  • [Title] A relative color approach to color discrimination for malignant melanoma detection in dermoscopy images.
  • BACKGROUND: Skin lesion color is an important feature for diagnosing malignant melanoma.
  • In previous research, skin lesion color was investigated for discriminating malignant melanoma lesions from benign lesions in clinical images.
  • Colors characteristics of melanoma were determined using color histogram analysis over a training set of images.
  • Percent melanoma color and color clustering ratio features were used to quantify the presence of melanoma-colored pixels within skin lesions for skin lesion discrimination.
  • METHODS: In this research, the relative color histogram analysis technique is used to evaluate skin lesion discrimination based on color feature calculations in different regions of the skin lesion in dermoscopy images.
  • The histogram analysis technique is examined for varying training set sizes from the set of 113 malignant melanomas and 113 benign dysplastic nevi images.
  • Recognition rates for malignant melanoma and dysplastic nevi as high as 87.7% and 74.9%, respectively, are observed for the color clustering ratio computed using the outer 75% uniformly distributed area with a 10% offset within the boundary.
  • CONCLUSIONS: Experimental results appear to indicate that the melanoma color feature information is located in the interior of the lesion, excluding the 10% central-most region.
  • The techniques presented here including the use of relative color and the determination of benign and malignant regions of the relative color histogram may be applicable to any set of images of benign and malignant lesions.

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  • [Cites] Arch Dermatol. 2003 Mar;139(3):361-7; discussion 366 [12622631.001]
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  • (PMID = 17250534.001).
  • [ISSN] 0909-752X
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R43 CA101639; United States / NCI NIH HHS / CA / R44 CA101639; United States / NCI NIH HHS / CA / CA 1019639-01; United States / NCI NIH HHS / CA / CA 60294-03
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS327041; NLM/ PMC3184887
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65. McGowan JW, Smith MK, Ryan M, Hood AF: Proliferative nodules with balloon-cell change in a large congenital melanocytic nevus. J Cutan Pathol; 2006 Mar;33(3):253-5
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  • [Title] Proliferative nodules with balloon-cell change in a large congenital melanocytic nevus.
  • The balloon-cell nevus was first described over 100 years ago.
  • Since then, balloon-cell changes of melanocytes have been noted in numerous tumors, including melanoma, blue nevus, and Spitz nevus.
  • We report a case in which balloon-cell changes were found within proliferative nodules occurring in a large congenital melanocytic nevus.
  • [MeSH-major] Melanocytes / pathology. Nevus, Pigmented / congenital. Nevus, Pigmented / pathology. Skin Neoplasms / congenital. Skin Neoplasms / pathology

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  • (PMID = 16466515.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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66. Gershtenson PC, Krunic A, Chen H, Konanahalli M, Worobec S: Subungual and periungual congenital blue naevus. Australas J Dermatol; 2009 May;50(2):144-7
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  • [Title] Subungual and periungual congenital blue naevus.
  • Subungual pigmented lesions should raise concern about malignant melanoma.
  • Blue naevus of the nail apparatus is a rare entity, with only ten cases described in the literature.
  • Initial biopsy was consistent with a blue naevus of the cellular type and, given the recent clinical change and periungual extension, complete excision was recommended.
  • Reconstruction was performed with a full-thickness skin graft.
  • We present a case of a congenital subungual and periungual blue naevus of the cellular type and review the literature on this rare presentation of a congenital blue naevus.
  • [MeSH-major] Nails / pathology. Nevus, Blue / congenital. Skin Neoplasms / congenital
  • [MeSH-minor] Female. Humans. Skin Transplantation. Treatment Outcome. Young Adult

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  • (PMID = 19397572.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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67. Piana S, Gelli MC, Grenzi L, Ricci C, Gardini S, Piana S: Multifocal melanoma arising on nevus spilus. Int J Dermatol; 2006 Nov;45(11):1380-1
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  • [Title] Multifocal melanoma arising on nevus spilus.
  • [MeSH-major] Lentigo / complications. Melanoma / etiology. Neoplasms, Multiple Primary / etiology. Skin Neoplasms / etiology

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  • (PMID = 17076737.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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68. Leadbeater NE, Smith RJ, Barnard TM: Using in situ Raman monitoring as a tool for rapid optimisation and scale-up of microwave-promoted organic synthesis: esterification as an example. Org Biomol Chem; 2007 Mar 7;5(5):822-5
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  • With conditions in hand, an automated stop-flow apparatus was used to prepare 5.7 moles of product.

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  • (PMID = 17315069.001).
  • [ISSN] 1477-0520
  • [Journal-full-title] Organic & biomolecular chemistry
  • [ISO-abbreviation] Org. Biomol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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69. Demerdjieva Z, Kavaklieva S, Tsankov N: Epidermal nevus syndrome and didymosis aplasticosebacea. Pediatr Dermatol; 2007 Sep-Oct;24(5):514-6
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  • [Title] Epidermal nevus syndrome and didymosis aplasticosebacea.
  • The epidermal nevus syndrome is a disease complex consisting of the association of an epidermal nevus with various developmental abnormalities of the skin, eyes, nervous, skeletal, cardiovascular, and urogenital systems.
  • The epidermal nevi are classified according to their predominant component; nevus sebaceus (sebaceous glands), nevus comedonicus (hair follicles), and nevus verrucosus (keratinocytes).
  • We report a neonate who presented with a nevus sebaceus on the scalp and face as well as a coloboma and dermoid on his left eye.
  • Within the sebaceous nevus on the scalp, circumscribed lesions of aplasia cutis congenita were detected, which is consistent with the recently proposed term in the literature didymosis aplasticosebacea.
  • [MeSH-major] Ectodermal Dysplasia / pathology. Hamartoma / pathology. Nevus / pathology


70. Phan A, Touzet S, Dalle S, Ronger-Savlé S, Balme B, Thomas L: Acral lentiginous melanoma: histopathological prognostic features of 121 cases. Br J Dermatol; 2007 Aug;157(2):311-8
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  • [Title] Acral lentiginous melanoma: histopathological prognostic features of 121 cases.
  • BACKGROUND: Acral lentiginous melanoma (ALM) is the fourth histopathological subtype of malignant melanoma, accounting for < 10% of all melanomas in white-skinned populations.
  • Several pathological parameters of interest in melanoma were evaluated for disease-free and specific survival with the Kaplan-Meier method and the Cox proportional hazards regression model.
  • Remnants of pre-existing naevus were found in four (3%) melanomas.
  • CONCLUSIONS: This is a detailed pathological study of a large cohort with ALM, an uncommon subtype of melanoma.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Mitotic Index. Neoplasm Invasiveness. Prognosis. Sentinel Lymph Node Biopsy

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  • (PMID = 17596173.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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71. Panitsas KE, Boyd CA, Meredith D: Evidence that the rabbit proton-peptide co-transporter PepT1 is a multimer when expressed in Xenopus laevis oocytes. Pflugers Arch; 2006 Apr;452(1):53-63
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  • The amount of PepT1-FLAG cRNA injected into the oocytes was kept constant, while the amount of W294F-PepT1 cRNA was increased over the mole fraction range of 0 to 1.
  • As the mole fraction of injected W294F-PepT1 increased, the uptake of D: -Phe-L: -Gln decreased.

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  • (PMID = 16465547.001).
  • [ISSN] 0031-6768
  • [Journal-full-title] Pflugers Archiv : European journal of physiology
  • [ISO-abbreviation] Pflugers Arch.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / PepT1 protein; 0 / RNA, Complementary; 0 / Symporters
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72. Saksena R, Ma X, Wade TK, Kovác P, Wade WF: Effect of saccharide length on the immunogenicity of neoglycoconjugates from synthetic fragments of the O-SP of Vibrio cholerae O1, serotype Ogawa. Carbohydr Res; 2005 Oct 17;340(14):2256-69
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  • The Ogawa CHO-BSA was inoculated at either a constant mass but differing moles, or equal moles but differing masses.

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  • (PMID = 16098493.001).
  • [ISSN] 0008-6215
  • [Journal-full-title] Carbohydrate research
  • [ISO-abbreviation] Carbohydr. Res.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI 47373; United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Glycoconjugates; 0 / Immunoglobulin M; 0 / Lipopolysaccharides; 0 / O Antigens; 0 / Peptide Fragments
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73. Fan FR, Mazzitelli CL, Brodbelt JS, Bard AJ: Electrochemical, spectroscopic, and mass spectrometric studies of the interaction of silver species with polyamidoamine dendrimers. Anal Chem; 2005 Jul 15;77(14):4413-22
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  • When the mole ratio of DDM to Ag+ is > or = 1, Ag+ binds with PAMAMG2OH to form a dominant 1:1 complex with a value of 1.1 x 10(7) M(-1).
  • When the mole ratio is < 1, q > or = 2.

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  • (PMID = 16013854.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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74. Cabanillas M, Aneiros A, Monteagudo B, Santos-García D, Suárez-Amor O, Ramírez-Santos A: Epidermal nevus syndrome associated with polyostotic fibrous dysplasia, CNS lipoma, and aplasia cutis. Dermatol Online J; 2009;15(10):7
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  • [Title] Epidermal nevus syndrome associated with polyostotic fibrous dysplasia, CNS lipoma, and aplasia cutis.
  • Epidermal nevus syndrome is a rare congenital sporadic neurocutaneous disorder characterized by an epidermal nevus and various developmental abnormalities of the skin, eyes, nervous, cardiovascular and urogenital systems.
  • We describe a patient with an extensive epidermal nevus associated with various organ abnormalities, particularly polyostotic fibrous dysplasia, central nervous system lipoma, and aplasia cutis.
  • Our patient demonstrates the polymorphic spectrum of involvement in epidermal nevus syndrome.
  • [MeSH-major] Ectodermal Dysplasia / complications. Fibrous Dysplasia, Polyostotic / complications. Lipoma / complications. Neoplasms, Multiple Primary. Nevus / complications. Skin Neoplasms / complications. Spinal Cord Neoplasms / complications


75. Prabhu MM, Baxi J, Malhothra A, Setty M, Sharma P: A perplexing case of gastrointestinal haemorrhage. Singapore Med J; 2006 Feb;47(2):159-62
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  • A 25-year-old Nepali woman presented with severe anaemia and massive gastrointestinal haemorrhage after normal pregnancy following evacuation of a hydatiform mole.
  • [MeSH-major] Choriocarcinoma / pathology. Gastrointestinal Hemorrhage / etiology. Hydatidiform Mole, Invasive / pathology. Jejunal Neoplasms / secondary

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  • (PMID = 16435061.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 12
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76. Agarwal A, Gupta S, Sharma RK: Role of oxidative stress in female reproduction. Reprod Biol Endocrinol; 2005;3:28
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  • There is growing literature on the effects of OS in female reproduction with involvement in the pathophysiology of preeclampsia, hydatidiform mole, free radical-induced birth defects and other situations such as abortions.
  • The review comprehensively explores the literature for evidence of the role of oxidative stress in conditions such as abortions, preeclampsia, hydatidiform mole, fetal embryopathies, preterm labour and preeclampsia and gestational diabetes.

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  • (PMID = 16018814.001).
  • [ISSN] 1477-7827
  • [Journal-full-title] Reproductive biology and endocrinology : RB&E
  • [ISO-abbreviation] Reprod. Biol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Reactive Oxygen Species; EC 1.14.13.39 / Nitric Oxide Synthase
  • [Number-of-references] 212
  • [Other-IDs] NLM/ PMC1215514
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77. Klecka GM, Naylor CG, Staples CA, Losey B: Occurrence of nonylphenol ethoxylates and their metabolites in municipal wastewater treatment plants and receiving waters. Water Environ Res; 2010 May;82(5):447-54
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  • In this study, three municipal activated sludge WWTPs, receiving primarily residential wastewater, were monitored, with their receiving waters, to determine the occurrence of NPEs and their biodegradation metabolites, including nonylphenol (NP), low-mole and higher-mole nonylphenol ethoxylates (NPE1, NPE2-8, and NPE > or =9), and nonylphenol ether carboxylates (NPECs).

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  • (PMID = 20480766.001).
  • [ISSN] 1061-4303
  • [Journal-full-title] Water environment research : a research publication of the Water Environment Federation
  • [ISO-abbreviation] Water Environ. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ethylene Glycols; 0 / Water Pollutants, Chemical; 27986-36-3 / terics
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78. Yang YP, Zhu YL, Wu WP, Wang ZM, Zhang JM: [Perivascular epithelioid cell tumor of uterus: report of 5 cases and literature review]. Zhonghua Bing Li Xue Za Zhi; 2007 May;36(5):302-6
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  • Immunohistochemically, the tumor cells demonstrated positive staining for melanocytic markers (HMB45 and/or Melan-A), desmin and smooth muscle actin.
  • Positivity for melanocytic markers (especially HMB45) plays an important role in the diagnosis of this tumor.
  • In general, the tumor is categorized as benign, with uncertain malignant potential and malignant.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Neoplasm Proteins / metabolism. Perivascular Epithelioid Cell Neoplasms / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adult. Desmin / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Immunohistochemistry. Leiomyoma, Epithelioid / pathology. Melanoma-Specific Antigens. Middle Aged

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  • (PMID = 17706136.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
  • [Number-of-references] 24
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79. Hussein MR, Elsers DA, Fadel SA, Omar AE: Immunohistological characterisation of tumour infiltrating lymphocytes in melanocytic skin lesions. J Clin Pathol; 2006 Mar;59(3):316-24
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  • [Title] Immunohistological characterisation of tumour infiltrating lymphocytes in melanocytic skin lesions.
  • We hypothesise that the transition from normal skin to benign naevi (BN) to melanocytic dysplastic naevi (MDN) to radial growth phase cutaneous malignant melanoma (RGP-CMM) to vertical growth phase cutaneous malignant melanoma (VGP-CMM) is associated with alterations in TIL.
  • This study attempted to test this hypothesis and to characterise TIL in the melanocytic skin lesions.
  • RESULTS: Histologically, the transitions from normal skin to BN to MDN to RGP-CMM to VGP-CMM was associated with a gradual increase in the numbers of TIL (total, parenchymal, stromal, perivascular, and epidermal TIL, as well as TIL at the base of the lesions).
  • All these differences between the normal skin and the lesional ones reached statistical significance (p<0.01).
  • CONCLUSIONS: The gradual increase in TIL during melanoma tumorigenesis may reflect increased antigenicity of the tumour cells.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lymphocytes, Tumor-Infiltrating / pathology. Melanocytes / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Analysis of Variance. Antigens, CD20 / analysis. Antigens, CD3 / analysis. Antigens, CD45 / analysis. Case-Control Studies. Disease Progression. Humans. Immunohistochemistry / methods. Immunophenotyping. Lymphocyte Count. Neoplasm Staging. Nevus / immunology. Nevus / pathology. T-Lymphocytes, Cytotoxic / pathology

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  • (PMID = 16505286.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD3; 0 / Biomarkers, Tumor; EC 3.1.3.48 / Antigens, CD45
  • [Other-IDs] NLM/ PMC1860334
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80. Nguyen TT, Gorman B, Shields D, Goodman Z: Malignant hepatic angiomyolipoma: report of a case and review of literature. Am J Surg Pathol; 2008 May;32(5):793-8
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  • Hepatic angiomyolipoma, a constituent of the group of tumors showing differentiation resembling perivascular epithelioid cells, is primarily appreciated in its benign form.
  • These tumors also possess similar immunohistochemical profiles, including positivity for melanocytic (HMB-45) and smooth muscle (smooth muscle actin) markers.
  • We will discuss the features that aid in distinguishing between benign and malignant HAML, and their similarities.
  • In summary, the common features of both benign and malignant HAML include the following: the 3 basic histologic components of AML, expression of melanocytic and smooth muscle markers, invasion into adjacent normal parenchyma, and cytologic atypia.
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adult. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Fatal Outcome. Female. Hepatectomy. Humans. Melanoma-Specific Antigens. Neoplasm Metastasis. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local

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  • (PMID = 18391749.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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81. Gupta N, Day AS: Editorial comment: blue rubber bleb naevus syndrome. J Paediatr Child Health; 2010 Jan;46(1-2):67-8
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  • [Title] Editorial comment: blue rubber bleb naevus syndrome.
  • [MeSH-major] Gastrointestinal Hemorrhage / diagnosis. Intestine, Small / physiopathology. Nevus, Blue / pathology. Skin Neoplasms / physiopathology

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  • [CommentOn] J Paediatr Child Health. 2010 Jan;46(1-2):63-5 [19943859.001]
  • [CommentOn] J Paediatr Child Health. 2010 Jan;46(1-2):68-9 [20412197.001]
  • (PMID = 20412196.001).
  • [ISSN] 1440-1754
  • [Journal-full-title] Journal of paediatrics and child health
  • [ISO-abbreviation] J Paediatr Child Health
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] Australia
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82. Sebire NJ: Hydatidiform mole and medical management of miscarriage. BMJ; 2006 Jun 17;332(7555):1454
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  • [Title] Hydatidiform mole and medical management of miscarriage.
  • [MeSH-major] Abortion, Spontaneous / drug therapy. Hydatidiform Mole / complications. Uterine Neoplasms / complications


83. Hughes SM, Wilkerson AE, Winfield HL, Hiatt KM: Familial nevus sebaceus in dizygotic male twins. J Am Acad Dermatol; 2006 Feb;54(2 Suppl):S47-8
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  • [Title] Familial nevus sebaceus in dizygotic male twins.
  • [MeSH-major] Diseases in Twins / genetics. Hamartoma / genetics. Scalp / pathology. Sebaceous Glands / pathology. Skin Diseases / genetics

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  • (PMID = 16427992.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't; Twin Study
  • [Publication-country] United States
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84. Ng EK, Cheung FK, Chiu PW: Blue rubber bleb nevus syndrome: treatment of multiple gastrointestinal hemangiomas with argon plasma coagulator. Dig Endosc; 2009 Jan;21(1):40-2
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  • [Title] Blue rubber bleb nevus syndrome: treatment of multiple gastrointestinal hemangiomas with argon plasma coagulator.
  • Blue rubber bleb nevus syndrome is a rare clinical entity characterized by the formation of multiple blue or purplish rubbery cavernous hemangiomas on the skin and other epithelial surfaces.

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  • (PMID = 19691801.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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85. Chander R, Varghese B, Jabeen M, Garg T, Jain M: CHILD syndrome with thrombocytosis and congenital dislocation of hip: A case report from India. Dermatol Online J; 2010;16(8):6
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  • Congenital Hemidysplasia with Ichthyosiform Nevus and Limb Defects (CHILD) is a very rare entity inherited as an X-linked trait.
  • [MeSH-major] Hip Dislocation, Congenital / diagnosis. Ichthyosiform Erythroderma, Congenital / diagnosis. Limb Deformities, Congenital / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis. Thrombocytosis / diagnosis

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  • (PMID = 20804683.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Emollients
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86. Bataille V: Early detection of melanoma improves survival. Practitioner; 2009 Oct;253(1722):29-32, 3
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  • [Title] Early detection of melanoma improves survival.
  • Melanoma affects 15 to 20 per 100, 000 in the UK.
  • Cancers such as breast and prostate are around ten times more common than melanoma.
  • It is the most common cancer between the age of 20 and 35 years in Caucasians but the incidence of melanoma is still very low in that age group.
  • Melanoma has different clinical presentations with different outcomes and management.
  • They may grow from a pre-existing naevus but also from normal skin.
  • Melanoma can appear on the palms and soles or under the nail and on those sites may present as a vascular non-pigmented lesion which may cause diagnostic problems.
  • Subjects with fair skin and hair have a two-fold increased risk of melanoma.
  • The presence of > 100 naevi with atypical naevi can increase the risk of melanoma five-to ten-fold.
  • Any new mole in a subject over 40 should be regarded as suspicious.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19938560.001).
  • [ISSN] 0032-6518
  • [Journal-full-title] The Practitioner
  • [ISO-abbreviation] Practitioner
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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87. Széll M, Balogh K, Dobozy A, Kemény L, Oláh J: First detection of the melanoma-predisposing proline-48-threonine mutation of p16 in Hungarians: was there a common founder either in Italy or in Hungary? Melanoma Res; 2007 Aug;17(4):251-4
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  • [Title] First detection of the melanoma-predisposing proline-48-threonine mutation of p16 in Hungarians: was there a common founder either in Italy or in Hungary?
  • The P48T germ line mutation of p16 was detected in a Hungarian multiple primary melanoma patient (deceased at the age of 39) with no affected family members.
  • Genetic analysis of the patient and his family revealed that the patient was homozygous for the mutation, whereas his parents (father currently aged 69 and mother 63), who are free from any malignancies and atypical moles, are both heterozygous for the mutation.
  • Our data suggest that the P48T mutation of p16 is a strong melanoma-predisposing factor, but the fact that the heterozygous mutant parents have not yet exhibited melanoma or atypical moles indicates that the penetrance of this allele might depend on modifying factors.
  • Here, we first report the inheritance of the rare P48T mutation of CDKN2A in a Hungarian family with a homozygous multiple primary melanoma member and unaffected heterozygous family members.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Founder Effect. Germ-Line Mutation. Melanoma / diagnosis. Melanoma / genetics. Proline / chemistry. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Threonine / chemistry

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  • (PMID = 17625456.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 2ZD004190S / Threonine; 9DLQ4CIU6V / Proline
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88. Ahyayauch H, Larijani B, Alonso A, Goñi FM: Detergent solubilization of phosphatidylcholine bilayers in the fluid state: influence of the acyl chain structure. Biochim Biophys Acta; 2006 Feb;1758(2):190-6
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  • For each case, the solubilization parameters, Don (total detergent: lipid mole ratio producing the onset of solubilization) and D50 (total detergent: lipid mole ratio producing 50% solubilization), were determined under equilibrium conditions.

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  • (PMID = 16579963.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Detergents; 0 / Lipid Bilayers; 0 / Phosphatidylcholines; 9002-93-1 / Octoxynol
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89. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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90. Avgerinou GP, Asvesti AP, Katsambas AD, Nikolaou VA, Christofidou EC, Grzeschik KH, Happle R: CHILD syndrome: the NSDHL gene and its role in CHILD syndrome, a rare hereditary disorder. J Eur Acad Dermatol Venereol; 2010 Jun;24(6):733-6
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  • [Title] CHILD syndrome: the NSDHL gene and its role in CHILD syndrome, a rare hereditary disorder.
  • BACKGROUND: CHILD syndrome, a rare hereditary disorder of keratinization (MIM 308050, 300275), is the acronym proposed by Happle to name a rare entity, characterized by congenital hemidysplasia, icthyosiform nevus and limb defects, ranging from digital hypoplasia to icthyosiform nevus and ipsilateral limb defects, ranging from digital hypoplasia to complete amelia.
  • PATIENTS AND METHODS: A 9-month-old female infant presented with skin and limb defects involving the right side of her body.
  • [MeSH-major] 3-Hydroxysteroid Dehydrogenases / genetics. Erythema / genetics. Limb Deformities, Congenital / genetics. Nevus / genetics

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  • (PMID = 19906044.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Databank-accession-numbers] OMIM/ 300275/ 308050
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 1.1.- / 3-Hydroxysteroid Dehydrogenases; EC 1.1.1.170 / Nsdhl protein, human
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91. Drescher M, Godschalk F, Veldhuis G, van Rooijen BD, Subramaniam V, Huber M: Spin-label EPR on alpha-synuclein reveals differences in the membrane binding affinity of the two antiparallel helices. Chembiochem; 2008 Oct 13;9(15):2411-6
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  • Protein binding to POPC/POPG vesicles for all but alphaS140 resulted in two mobility components with correlation times of 0.5 and 3 ns, for POPG mole fractions >0.4.
  • Monitoring these components as a function of the POPG mole fraction revealed that at low negative-charge densities helix 1 is more tightly bound than helix 2; this indicates a partially bound form of alphaS.

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  • (PMID = 18821550.001).
  • [ISSN] 1439-7633
  • [Journal-full-title] Chembiochem : a European journal of chemical biology
  • [ISO-abbreviation] Chembiochem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Membranes, Artificial; 0 / Spin Labels; 0 / alpha-Synuclein
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92. Sterry W: [Innovative control of extreme nevus dysplasia syndromes]. J Dtsch Dermatol Ges; 2009 Sep;7(9):733
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  • [Title] [Innovative control of extreme nevus dysplasia syndromes].
  • [MeSH-major] Nevus, Pigmented / prevention & control. Precancerous Conditions / prevention & control. Skin Neoplasms / prevention & control

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  • (PMID = 19712225.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] Editorial
  • [Publication-country] Germany
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93. Dominguez-Cherit J, Toussaint-Caire S, Kamino H, Iorizzo M, Tosti A: Subungual spitz nevus in a Hispanic infant. Dermatol Surg; 2008 Nov;34(11):1571-3
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  • [Title] Subungual spitz nevus in a Hispanic infant.
  • [MeSH-major] Nail Diseases. Nevus, Epithelioid and Spindle Cell. Skin Neoplasms

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  • (PMID = 18798747.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Lee WJ, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK, Bak H: Bilateral mucinous eccrine nevus in an adult. J Dermatol; 2008 Aug;35(8):552-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral mucinous eccrine nevus in an adult.

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  • (PMID = 18789080.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
  • [Chemical-registry-number] F446C597KA / Triamcinolone Acetonide
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95. Bett BJ: Large or multiple congenital melanocytic nevi: occurrence of neurocutaneous melanocytosis in 1008 persons. J Am Acad Dermatol; 2006 May;54(5):767-77
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  • [Title] Large or multiple congenital melanocytic nevi: occurrence of neurocutaneous melanocytosis in 1008 persons.
  • BACKGROUND: There is a dearth of information regarding the occurrence of neurocutaneous melanocytosis (NCM) in a large cohort of persons with large congenital melanocytic nevi (LMCN) or multiple congenital melanocytic nevi (MCMN).
  • METHODS: Evaluation of information obtained from a database of persons with LCMN or MCMN voluntarily submitted by the affected persons to a nevus support group, the Nevus Network.
  • RESULTS: Of those with truncal LCMN, 6.8% developed significant complications, 4.8% developed symptomatic NCM, and 2.3% died from either benign or malignant NCM or cutaneous melanoma.
  • Of the 4.8% of persons with a truncal nevus who developed symptomatic NCM, 34% died.
  • Of the small number with MCMN without a giant nevus, 71% developed symptomatic NCM, and 41% died of it.
  • If symptomatic NCM developed in those with truncal nevi, the occurrence of death rose to a third.
  • [MeSH-major] Melanoma / etiology. Nevus, Pigmented / complications. Skin Neoplasms / etiology

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  • (PMID = 16635656.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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96. Patel RC, Zynger DL, Laskin WB: Blue rubber bleb nevus syndrome: novel lymphangiomatosis-like growth pattern within the uterus and immunohistochemical analysis. Hum Pathol; 2009 Mar;40(3):413-7
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  • [Title] Blue rubber bleb nevus syndrome: novel lymphangiomatosis-like growth pattern within the uterus and immunohistochemical analysis.
  • Blue Rubber Bleb Nevus Syndrome is a rare, primarily sporadic condition characterized by vascular lesions principally involving the skin and gastrointestinal tract.
  • This case of Blue Rubber Bleb Nevus Syndrome demonstrated a labyrinth of variably sized vascular spaces lined by an attenuated layer of bland endothelial cells, dissecting uterine tissues and sequestering remaining myometrium.
  • This report expands the morphological spectrum of vascular lesions in Blue Rubber Bleb Nevus Syndrome to include a lymphangiomatosis-like growth pattern and the immunohistochemistry suggests dual vascular and lymphatic differentiation, supporting the current belief that these lesions are malformations.
  • [MeSH-major] Lymphangioma / pathology. Nevus, Blue / pathology. Uterine Neoplasms / pathology


97. Hoffner L, Parks WT, Swerdlow SH, Carson JC, Surti U: Simultaneous detection of imprinted gene expression (p57(KIP2)) and molecular cytogenetics (FICTION) in the evaluation of molar pregnancies. J Reprod Med; 2010 May-Jun;55(5-6):219-28
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  • The unusual cases included androgenetic/ biparental chimeric complete hydatidiform moles (CHM) and mosaic partial hydatidiform moles (PHM).
  • [MeSH-major] Autoantibodies / analysis. Chimera / genetics. Cyclin-Dependent Kinase Inhibitor p57 / genetics. Hydatidiform Mole / genetics. Uterine Neoplasms / genetics

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  • (PMID = 20626178.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Cyclin-Dependent Kinase Inhibitor p57
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98. Ota H, Kimura Y, Kawai H, Ogawa J: Mediastinal lymphangiomyoma in an adult: Report of a case. Surg Today; 2010 Apr;40(4):365-8
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  • Lymphangiomyoma is a rare benign hamartoma of lymphatic origin.
  • Hamartomatous lymphangiomyoma is not expressed by markers for secondary lymphangiomyoma of lymphangioleiomyoma, including human-melanoma-black-45 and progesterone receptor.

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  • (PMID = 20339992.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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99. Tunc I, Guvenc HO, Sezen H, Suzer S, Correa-Duarte MA, Liz-Marzán LM: Optical response of Ag-Au bimetallic nanoparticles to electron storage in aqueous medium. J Nanosci Nanotechnol; 2008 Jun;8(6):3003-7
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  • The extent of this blue shift increases non-linearly with the mole fraction of silver in the nanoparticle, parallel to the trends reported previously for both the frequency and the extinction coefficient of the plasmon band shifts.

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  • (PMID = 18681038.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Dinda E, Si S, Kotal A, Mandal TK: Novel ascorbic acid based ionic liquids for the in situ synthesis of quasi-spherical and anisotropic gold nanostructures in aqueous medium. Chemistry; 2008;14(18):5528-37
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  • It has been found that the nature of the ionic liquids and the mole ratio of ionic liquid to HAuCl4 has a significant effect on the morphology of the formed gold nanostructures.

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  • (PMID = 18470852.001).
  • [ISSN] 0947-6539
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 059QF0KO0R / Water; 7440-57-5 / Gold; PQ6CK8PD0R / Ascorbic Acid
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