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[Title] Metastatic vertebral tumor misdiagnosed in magnetic resonance imaging as benign degenerative bone marrow changes: a case report.

We report a man with low back and right groin pain as a result of metastatic breast carcinoma which was misdiagnosed in magnetic resonance imaging as benign degenerative changes.

[MeSH-major] Adenocarcinoma / secondary. Bone Marrow / pathology. Bone Neoplasms / secondary. Breast Neoplasms, Male / pathology. Diagnostic Errors. Lumbar Vertebrae / pathology. Magnetic Resonance Imaging

[MeSH-minor] Humans. Low Back Pain / etiology. Male. Middle Aged. Radiography. Radionuclide Imaging

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[Cites] Radiology. 1985 Oct;157(1):157-66 [3875878.001]

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(PMID = 15449024.001).

[ISSN] 0172-8172

[Journal-full-title] Rheumatology international

[ISO-abbreviation] Rheumatol. Int.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Germany

   

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[Title] From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation.

The spectrum of breast lesions in children and adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign.

A breast mass in a young boy or girl may arise from normal and abnormal breast development.

After onset of puberty, most cases of breast enlargement arise from benign fibroadenoma in girls and gynecomastia in boys.

These conditions have specific imaging appearances, although juvenile (often giant) fibroadenoma cannot be distinguished from phyllodes tumor, which can be benign or malignant.

A diagnosis of juvenile papillomatosis (a benign lesion) portends later development of breast cancer, and patients with this condition should be closely monitored.

Malignant lesions of the breast in children are rare.

The most common primary breast malignancy is malignant phyllodes tumor.

Primary breast carcinoma is exceedingly rare in the pediatric age group, but its imaging appearance in children is the same as seen in adults and is different from that of almost all benign lesions.

In girls, diagnostic interventions may injure the developing breast and cause subsequent disfigurement.

Given this risk and the low prevalence of malignant disease in this population, a prudent course should be followed in the diagnosis of breast lesions.

[MeSH-major] Breast Diseases / radiography

[MeSH-minor] Adolescent. Breast / abnormalities. Breast / anatomy & histology. Breast / growth & development. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms, Male / diagnosis. Breast Neoplasms, Male / pathology. Breast Neoplasms, Male / radiography. Breast Neoplasms, Male / secondary. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / radiography. Carcinoma, Ductal, Breast / ultrasonography. Child. Child, Preschool. Female. Fibroadenoma / diagnosis. Fibroadenoma / pathology. Fibroadenoma / radiography. Granular Cell Tumor / diagnosis. Granular Cell Tumor / pathology. Granular Cell Tumor / radiography. Gynecomastia / pathology. Gynecomastia / radiography. Humans. Infant. Infant, Newborn. Male. Nipples / abnormalities. Papilloma / diagnosis. Papilloma / pathology. Papilloma / radiography. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology. Phyllodes Tumor / radiography. Puberty. Puberty, Precocious / diagnosis. Young Adult

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(PMID = 19448124.001).

[ISSN] 1527-1323

[Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc

[ISO-abbreviation] Radiographics

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 90

   

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[Title] Identification of cripto-1 as a novel serologic marker for breast and colon cancer.

We evaluated whether CR-1 is present in the plasma of patients with breast and colon cancer, and if it can represent a new biomarker for these malignancies.

EXPERIMENTAL DESIGN: We determined CR-1 plasma levels using a sandwich-type ELISA in 21 healthy volunteers, 54 patients with breast cancer, 33 patients with colon carcinoma, and 21 patients with benign breast lesions.

A statistically significant increase in the levels of plasma CR-1 was found in patients with colon carcinoma (4.68+/-3.5 ng/mL) and in patients with breast carcinoma (2.97+/-1.48 ng/mL; P<0.001).

Although moderate levels of plasma CR-1 were found in women with benign lesions of the breast (1.7+/-0.99 ng/mL), these levels were significantly lower than in patients with breast cancer (P<0.001).

Finally, immunohistochemical analysis and real-time reverse transcription-PCR confirmed strong positivity for CR-1 in colon and/or breast tumor tissues.

CONCLUSION: This study suggests that plasma CR-1 might represent a novel biomarker for the detection of breast and colon carcinomas.

[MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Breast Neoplasms / diagnosis. Colonic Neoplasms / blood. Colonic Neoplasms / diagnosis. Epidermal Growth Factor / blood. Membrane Glycoproteins / blood. Neoplasm Proteins / blood

[MeSH-minor] Animals. Enzyme-Linked Immunosorbent Assay / methods. Female. GPI-Linked Proteins. Humans. Immunohistochemistry / methods. Intercellular Signaling Peptides and Proteins. Male. Mice. Mice, Transgenic. Neoplasm Staging. Reverse Transcriptase Polymerase Chain Reaction / methods. Sensitivity and Specificity

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(PMID = 16951234.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Grant] United States / Intramural NIH HHS / /

[Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPI-Linked Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / TDGF1 protein, human; 62229-50-9 / Epidermal Growth Factor

   

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Forced expression of Cks1 and Cks2 in benign prostate tumor epithelial cells promoted cell population growth.

Knockdown of Cks1 expression in malignant prostate tumor cells inhibited proliferation, anchorage-independent growth, and migration activities, whereas knockdown of Cks2 expression induced programmed cell death and inhibited the tumorigenicity.

Collectively, the data suggest that elevated expression of Cks1 contributes to the tumorigenicity of prostate tumor cells by promoting cell growth and elevated expression of Cks2 protects the cells from apoptosis.

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(PMID = 18498131.001).

[ISSN] 1097-0215

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA096824-01A1; United States / NCI NIH HHS / CA / R01 CA096824-01A1; United States / NCI NIH HHS / CA / CA096824-05; United States / NCI NIH HHS / CA / R01 CA096824-05; United States / NCI NIH HHS / CA / R56 CA096824; United States / NCI NIH HHS / CA / CA096824; United States / NCI NIH HHS / CA / R01 CA096824

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / CKS1B protein, human; 0 / CKS2 protein, human; 0 / Carrier Proteins; 0 / Cell Cycle Proteins; 0 / DNA, Complementary; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.11.22 / CDC2-CDC28 Kinases; EC 2.7.11.22 / CDC28 Protein Kinase, S cerevisiae; EC 2.7.11.22 / Cks1 protein, mouse; EC 2.7.11.22 / Cks2 protein, mouse; EC 2.7.11.22 / Cyclin-Dependent Kinases

[Other-IDs] NLM/ NIHMS93124; NLM/ PMC3262990

   

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METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed.

The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases.

RESULTS: One hundred patients with 59 malignant (43 colon, 5 breast, 2 endocrine metastases, 7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas, 7 focal nodular hyperplasias, 5 complicated cysts, 2 abscesses and 12 circumscribed fatty changes) tumors were included.

The late venous phase proved to be the most sensitive for classification of the tumor type.

Of the 41 benign tumors, 37 were classified as true negative and 4 as false negative, which corresponds to a specificity of 90.2%.

[MeSH-minor] Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Germany. Humans. Image Interpretation, Computer-Assisted. Magnetic Resonance Angiography. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Prospective Studies. ROC Curve. Reproducibility of Results. Sensitivity and Specificity. Time Factors. Tomography, X-Ray Computed

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(PMID = 18081224.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Controlled Clinical Trial; Evaluation Studies; Journal Article; Multicenter Study

[Publication-country] China

[Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride

[Other-IDs] NLM/ PMC4205454

   

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PURPOSE: Married (vs. unmarried) individuals have improved health status and longer life expectancies in a variety of benign and malignant disease states, including prostate, breast, head/neck, and lung cancers.

Married individuals (vs. unmarried) were more often male (84 vs. 62%) and had a higher BMI (28.1 vs. 25.9).

These findings may support the evidence (observed in other tumor types and other disease states) that married persons present earlier than unmarried individuals, and this may help explain the improved survival outcomes that have been observed in married patients with bladder cancer.

[MeSH-major] Carcinoma, Transitional Cell / diagnosis. Carcinoma, Transitional Cell / surgery. Cystectomy. Marital Status. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / surgery

[MeSH-minor] Aged. Cohort Studies. Creatinine / blood. Female. Follow-Up Studies. Hematocrit. Humans. Length of Stay. Male. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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(PMID = 19219612.001).

[ISSN] 1433-8726

[Journal-full-title] World journal of urology

[ISO-abbreviation] World J Urol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] AYI8EX34EU / Creatinine

   

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[Title] Pleural fluid mesothelin for the differential diagnosis of exudative pleural effusions.

BACKGROUND: Malignant mesothelioma (MM) is a highly aggressive tumor that can be difficult to diagnose, resulting in a delayed diagnosis in some cases.

Recent studies have reported that determination of soluble mesothelin-related peptides (SMRP) in pleural fluid may be a promising marker for use in the diagnosis of MM.

PATIENTS AND METHODS: Pleural fluid SMRP concentration was measured in 68 patients: 47 had malignant pleural effusions (18 MM and 29 metastatic effusion) and 21 had benign pleural effusion (8 infectious disease and 13 idiopathic effusion).

Mann-Whitney analysis was used to compare SMRP values according to the etiology of the effusion.

RESULTS: Pleural fluid SMRP concentration was significantly higher in patients with malignant pleural effusion than in those with benign effusion (P=0.02).

CONCLUSIONS: Soluble mesothelin-related peptide measurement in pleural fluid may aid in the diagnosis of patients presenting with pleural effusion.

[MeSH-major] Adenocarcinoma / diagnosis. Breast Neoplasms / diagnosis. Carcinoma, Small Cell / diagnosis. Hematologic Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Membrane Glycoproteins / analysis. Mesothelioma / diagnosis. Ovarian Neoplasms / diagnosis. Pancreatic Neoplasms / diagnosis. Pleural Effusion / diagnosis. Pleural Effusion, Malignant / diagnosis

[MeSH-minor] Biomarkers. Diagnosis, Differential. Female. GPI-Linked Proteins. Humans. Male. Prospective Studies. Sensitivity and Specificity. Statistics, Nonparametric

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(PMID = 19783262.001).

[ISSN] 0025-7753

[Journal-full-title] Medicina clínica

[ISO-abbreviation] Med Clin (Barc)

[Language] eng

[Publication-type] Comparative Study; Evaluation Studies; Journal Article

[Publication-country] Spain

[Chemical-registry-number] 0 / Biomarkers; 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin

   

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They are usually benign, but as they are infrequently diagnosed preoperatively, they may be confused clinically with malignant lesions.

Of these, 99patients were female and 23 male, providing a male:female ratio of l to 4.3.

Lesions ranged in size from 0.2 cm to 10 cm in greatest dimension, the average size being 1.85 cm and were found in a diverse array of anatomic locations, the most common being the vulva, breast and tongue.

The correct clinical diagnosis was proffered preoperatively in only one case.

In contrast, a malignant diagnosis was suggested in 19 cases.

In particular lesions of the tongue accounted for fewer than expected, while lesions of the breast and vulva were considerably increased.

[MeSH-major] Granular Cell Tumor / epidemiology. Granular Cell Tumor / pathology

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Breast Neoplasms / epidemiology. Child. Child, Preschool. Female. Hospitals, University. Humans. Infant. Infant, Newborn. Male. Middle Aged. Tongue Neoplasms / epidemiology. Vulvar Neoplasms / epidemiology. West Indies / epidemiology. Young Adult

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(PMID = 21866599.001).

[ISSN] 0043-3144

[Journal-full-title] The West Indian medical journal

[ISO-abbreviation] West Indian Med J

[Language] eng

[Publication-type] Journal Article

[Publication-country] Jamaica

   

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[Title] Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells.

The effects of progesterone on breast epithelial cells remain poorly defined with observations showing both proliferative and antiproliferative effects.

The release of paracrine growth factors from nuclear receptor-positive cells has been postulated as a mechanism, since in vitro studies show a lack of growth effect by progesterone in breast epithelial cells lacking nuclear receptors.

This study examined possible nongenomic effects of progesterone in breast epithelia by using MCF-10A cells known to lack nuclear progesterone receptor expression.

Our study demonstrates a nongenomic action of progesterone on benign breast epithelial cells, resulting in enhanced cellular respiration and protection from apoptosis.

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(PMID = 19690070.001).

[ISSN] 1522-1555

[Journal-full-title] American journal of physiology. Endocrinology and metabolism

[ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.

[Language] ENG

[Grant] United States / NICHD NIH HHS / HD / 1R03HD-052770-01

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD95; 0 / Inhibitor of Differentiation Protein 1; 0 / Protein Synthesis Inhibitors; 0 / Receptors, Progesterone; 0 / Transforming Growth Factor beta1; 4G7DS2Q64Y / Progesterone; 8L70Q75FXE / Adenosine Triphosphate; 98600C0908 / Cycloheximide; EC 3.4.21.- / Kallikreins; EC 3.4.22.- / Caspases; EC 3.4.24.- / Matrix Metalloproteinases

   

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RESULTS: Prostatic stromal hyperplasia with atypia consists of 1 or more ill-defined, uncircumscribed, hyperplastic stromal nodules, with variable numbers of atypical, bizarre giant cells, with vacuolated nuclei, smudged chromatin, and frequent multinucleation infiltrating around benign acini.

CONCLUSIONS: Prostatic stromal hyperplasia with atypia is a rare, benign lesion, composed of degenerative myocytes with atypia that is histologically and clinically reminiscent of benign counterparts in the myometrium, breast, vulva, vagina, and elsewhere.

Recognition of this distinctive entity should allow separation from phyllodes tumor and sarcoma of the prostate.

The phrase stromal tumor of uncertain malignant potential is inappropriate for this benign tumor, and its use is discouraged.

[MeSH-major] Prostatic Hyperplasia / diagnosis. Prostatic Hyperplasia / pathology. Stromal Cells / pathology

[MeSH-minor] Aged. Aged, 80 and over. Cell Nucleus / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Muscle Cells / metabolism. Muscle Cells / pathology. Receptors, Androgen / metabolism. Retrospective Studies. Vimentin / metabolism

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(PMID = 18976007.001).

[ISSN] 1543-2165

[Journal-full-title] Archives of pathology & laboratory medicine

[ISO-abbreviation] Arch. Pathol. Lab. Med.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Receptors, Androgen; 0 / Vimentin

   

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[Title] Granular cell tumour of the male breast.

Granular cell tumour (GCT) is a rare neoplasm that can be found in multiple sites throughout the body.

Occasionally GCT is located in the breast.

In general, it appears as a singular benign lesion, although it can be multi-focal and rare cases with malignant behaviour have been reported.

We report a rare case of granular cell tumour of the nipple in the male breast, treated by wide local excision.

[MeSH-major] Breast Neoplasms, Male / surgery. Granular Cell Tumor / surgery

[MeSH-minor] Aged. Humans. Immunohistochemistry. Male. Nipples

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(PMID = 18411585.001).

[ISSN] 0001-5458

[Journal-full-title] Acta chirurgica Belgica

[ISO-abbreviation] Acta Chir. Belg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Belgium

   

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Discovering new melanoma biomarkers would improve early detection and diagnosis.

Volatiles released from fresh biopsy tissue of melanoma and benign naevus were compared based on their difference in frequency distribution and their expression level.

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(PMID = 21079799.001).

[ISSN] 1932-6203

[Journal-full-title] PloS one

[ISO-abbreviation] PLoS ONE

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA132046-02; United States / NCI NIH HHS / CA / R21 CA132046; United States / NCI NIH HHS / CA / R21CA 132046; United States / NCI NIH HHS / CA / R21 CA132046-01A1; United States / NCI NIH HHS / CA / R21 CA132046-02

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Volatile Organic Compounds

[Other-IDs] NLM/ PMC2973952

   

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[Title] Bilateral hilar foci on 18F-FDG PET scan in patients without lung cancer: variables associated with benign and malignant etiology.

Our objective was to evaluate features of these foci associated with benign or malignant etiology.

Variables evaluated were maximum standard uptake values (SUV max), purity (absence of (18)F-FDG-avid foci in nonhilar mediastinal nodes), symmetry (difference between left and right side SUV max), the primary tumor, node size determined by CT, and, in those who participated in 2 studies, stability of uptake over time.

The gold standard was histologic diagnosis or long-term clinical follow-up (range, 19-41 mo; mean, 25 mo).

On univariate analysis, variables associated with malignancy were SUV max (6.6+/-4.1 vs. 3.5+/-1.0 for benign, P<0.001; t test); impurity (P<0.001; chi(2) test), with 79% of impure scans versus 18% of pure scans being malignant; node size determined by CT (P=0.027); and change in uptake between scans 1 and 2 (change in SUV=2.7+/-2.1 vs. 0.73+/-1.1 for benign, P < 0.01; t test).

Variables associated with benign etiology were: symmetry (difference between left and right sides=0.57+/-0.54 for benign vs. 1.8+/-1.7 for malignant, P<0.01), purity, and colorectal primary (75% of colorectal were benign vs. 34% of breast, 49% of lymphoma, and 37% of other, P=0.030; chi(2) test).

CONCLUSION: In patients with nonlung cancer, in particular colorectal, foci of symmetric and mild uptake limited to the hilar regions that are stable on 2 sequential PET studies despite intervening anticancer therapy are likely related to a benign etiology.

[MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Radiopharmaceuticals. Reproducibility of Results. Sensitivity and Specificity

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[CommentIn] J Nucl Med. 2009 Mar;50(3):489-90 [19223415.001]

(PMID = 18765585.001).

[ISSN] 0161-5505

[Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine

[ISO-abbreviation] J. Nucl. Med.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18

   

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[Title] Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary (BBIA) approach.

The present study reviews our experiences with endoscopic thyroidectomy using bilateral breast areola and ipsilateral axillary (BBIA) approach to evaluate its safety and feasibility.

METHODS: From June 2003 through November 2007, the study group was comprised of 68 consecutive patients with benign thyroid nodules (66 women; mean age, 33.28 +/- 10.3 (range, 15-72) years).

RESULTS: The mean maximum diameter of the tumor was 3.14 +/- 1.61 (range, 1-10.7) cm.

[MeSH-minor] Adolescent. Adult. Aged. Cohort Studies. Feasibility Studies. Female. Humans. Length of Stay. Male. Middle Aged. Nipples. Retrospective Studies. Treatment Outcome. Young Adult

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(PMID = 18668282.001).

[ISSN] 0364-2313

[Journal-full-title] World journal of surgery

[ISO-abbreviation] World J Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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The clinical significance of serum interleukin-6 (IL-6) and its correlation with cystatin C (Cyst C), an endogenous inhibitor of cysteine proteinase cathepsin K, was investigated by immunoassays in patients with bone metastasis from breast cancer (BCa) or prostate cancer (PCa).

Mean IL-6 levels were also higher in PCa patients and in patients with benign prostatic hyperplasia (BPH) than in HS while Cyst C resulted significantly higher in PCa but not in BPH patients as compared to HS.

[MeSH-major] Bone Neoplasms / blood. Bone Neoplasms / secondary. Breast Neoplasms / pathology. Cystatin C / blood. Interleukin-6 / blood. Prostatic Neoplasms / pathology

[MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Bone Density Conservation Agents / therapeutic use. Diphosphonates / therapeutic use. Female. Humans. Imidazoles / therapeutic use. Male. Middle Aged. Osteoporosis / blood. Osteoporosis / complications. Prostate-Specific Antigen / blood. ROC Curve

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(PMID = 18461289.001).

[ISSN] 1357-0560

[Journal-full-title] Medical oncology (Northwood, London, England)

[ISO-abbreviation] Med. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Bone Density Conservation Agents; 0 / Cystatin C; 0 / Diphosphonates; 0 / Imidazoles; 0 / Interleukin-6; 6XC1PAD3KF / zoledronic acid; EC 3.4.21.77 / Prostate-Specific Antigen

   

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The peripheral washout sign was first described in delayed dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a small molecular contrast medium in solid lesions of the human breast and liver.

It was found to be 100% specific for malignant lesions and could therefore potentially be used as an additional noninvasive diagnostic tool differentiating malignant from benign lesions.

[MeSH-minor] Animals. Cell Line, Tumor. Male. Rats. Rats, Inbred Strains. Sensitivity and Specificity

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(PMID = 19178675.001).

[ISSN] 1476-5829

[Journal-full-title] Veterinary and comparative oncology

[ISO-abbreviation] Vet Comp Oncol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Contrast Media

   

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BACKGROUND: To assess the incidence of malignant tumors in patients with thrombophlebitis of the leg with regard to potential early tumor detection.

RESULTS: There were 18 patients (12.9%) suffering from thrombophlebitis in association with a malignant tumor: breast cancer in seven patients, colon carcinoma and haematologic cancer in four, skin cancer in three patients and one case each of oesophageal, prostatic, kidney and neck cancer .

In two patients thrombophlebitis preceded the diagnosis of the malignancy.

Superficial thrombophlebitis may have been associated in four cases (2.9%) with a benign tumor.

CONCLUSIONS: Breast, colonic, haematological and skin cancer were mainly associated with superficial thrombophlebitis in our patients.

In case of a thrombophlebitis without a known malignancy a thorough clinical examination with special regard to skin, breast and abdomen is mandatory.

[MeSH-minor] Adult. Aged. Aged, 80 and over. Comorbidity. Cross-Sectional Studies. Early Diagnosis. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Retrospective Studies. Ultrasonography, Doppler, Duplex. Venous Insufficiency / complications. Venous Insufficiency / epidemiology. Venous Insufficiency / ultrasonography

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(PMID = 19588305.001).

[ISSN] 0301-1526

[Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten

[ISO-abbreviation] VASA

[Language] eng

[Publication-type] Journal Article

[Publication-country] Switzerland

   

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[Title] Malignant lesions initially categorized as probably benign breast lesions: retrospective review of ultrasonographic, clinical and pathologic characteristics.

The primary objective of this study was to review the ultrasonographic features of BI-RADS category 3 ("probably benign") lesions that eventually proved to be malignant.

Thirty-two (0.8%) of 4000 women with lesions that were initially classified as "probably benign" proved to be malignant and formed the study group.

There was no statistical difference in the mean age, mean size of lesions, or tumor stage between patients who underwent early biopsy (n = 19) or biopsy after 6 months (n = 13).

[MeSH-major] Biopsy / statistics & numerical data. Breast Neoplasms / diagnosis. Breast Neoplasms / epidemiology. Ultrasonography, Mammary / statistics & numerical data

[MeSH-minor] Adult. Aged. Female. Humans. Korea / epidemiology. Male. Middle Aged. Prevalence. Reproducibility of Results. Retrospective Studies. Risk Assessment. Risk Factors. Sensitivity and Specificity

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[Copyright] Copyright 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

(PMID = 20350681.001).

[ISSN] 1879-291X

[Journal-full-title] Ultrasound in medicine & biology

[ISO-abbreviation] Ultrasound Med Biol

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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Trichoblastomas are rare, benign tumors of the appendix in human skin.

This mutation at codon 1,315 represents an already described PTCH germline polymorphism and results in a heterozygous Pro to Leu substitution in the tumor.

The Pro/Leu polymorphism in germline is associated with a higher risk for breast cancer, but a potential contribution to the tumorigenesis of trichoblastoma is unknown.

The genetic basis of this rare appendageal tumor remains elusive.

[MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. DNA Mutational Analysis. Female. Humans. Male. Middle Aged. Mutation. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational

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(PMID = 17597182.001).

[ISSN] 0046-8177

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors

   

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This damage leads to mutations that can initiate breast and prostate cancer.

To determine whether this damage occurs in humans, urine samples from men with prostate cancer and benign urological conditions, and healthy controls were analyzed.

RESULTS: 4-OHE1-1-N3Ade was detected at higher levels in samples from subjects with prostate cancer (n = 7) and benign urological conditions (n = 4) compared to healthy males (n = 5).

[MeSH-major] Biomarkers, Tumor / urine. DNA Adducts / urine. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / urine

[MeSH-minor] Antibodies, Monoclonal. Early Diagnosis. Electrophoresis, Capillary. Estradiol / analogs & derivatives. Estradiol / chemistry. Estradiol / immunology. Estradiol / urine. Estrogens, Catechol. Humans. Hydroxyestrones / chemistry. Hydroxyestrones / immunology. Hydroxyestrones / urine. Male. Risk Factors

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[Copyright] (c) 2006 Wiley-Liss, Inc.

(PMID = 16894534.001).

[ISSN] 0270-4137

[Journal-full-title] The Prostate

[ISO-abbreviation] Prostate

[Language] eng

[Grant] United States / PHS HHS / / 1 P20 RP15563; United States / NCI NIH HHS / CA / 2P01 CA49210-12

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / DNA Adducts; 0 / Estrogens, Catechol; 0 / Hydroxyestrones; 3131-23-5 / 4-hydroxyestrone; 4TI98Z838E / Estradiol; C3ZO03450E / 4-hydroxyestradiol

   

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Consumption of lycopene, a carotenoid without provitamin A activity, has been associated with a lower risk of prostate and breast cancer.

The effects of grapefruit-derived and commercial lycopene and lutein preparations on androgen independent cultured malignant type II tumor cells [Dunning R3327AT3 or AT3 cells (androgen-responsive, slow-growing tumor cells with well developed epithelium and stroma)] were compared to their benign parent type I tumor epithelial cells (DTE).

No such effect was observed when benign DTE cells were examined, demonstrating selective inhibition of extremely malignant AT3 prostate cancer cells relative to their benign parent.

[MeSH-minor] Animals. Chromatography, High Pressure Liquid. Citrus paradisi. Dose-Response Relationship, Drug. Humans. Male. Rats. Time Factors. Tumor Cells, Cultured

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(PMID = 17640163.001).

[ISSN] 0163-5581

[Journal-full-title] Nutrition and cancer

[ISO-abbreviation] Nutr Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Antioxidants; 36-88-4 / Carotenoids; SB0N2N0WV6 / lycopene; X72A60C9MT / Lutein

   

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CD10 is a cell surface peptidase expressed in a wide variety of normal and neoplastic tissues, including breast myoepithelial cells.

In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms.

The high expression of CD10 by this carcinoma can be a valuable tool to separate EMEC from the tubular variant of adenoid cystic carcinomas in small incisional biopsies, where the precise diagnosis may be impossible.

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(PMID = 19752720.001).

[ISSN] 1533-4058

[Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM

[ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.

[Language] ENG

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin

   

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[Title] A large benign vascular neoplasm of the male breast. A case report and review of the literature.

Breast hemangiomas are extremely rare neoplasms in the male population.

We report a case of a 77-year old man with a breast hemangioma which was detected in physical examination as a small nodule ten years after a chest injury.

The final histological diagnosis was hemangioma of the breast, 6 cm in the largest diameter.

To our knowledge, this is the largest benign vascular breast neoplasm in a male patient reported up to date.

The rarity of the lesion and its differential diagnosis from angiosarcoma are discussed while the problems encountered in the correct diagnosis and classification of this tumor are also presented.

The need for extreme caution in the interpretation of the histological characteristics of all palpable vascular tumors of the breast is emphasized.

[MeSH-major] Breast Neoplasms, Male / diagnosis. Hemangioma / diagnosis

[MeSH-minor] Aged. Humans. Male. Mastectomy, Segmental

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[CommentIn] Eur J Gynaecol Oncol. 2005;26(6):667; author reply 667-8 [16398236.001]

(PMID = 16122203.001).

[ISSN] 0392-2936

[Journal-full-title] European journal of gynaecological oncology

[ISO-abbreviation] Eur. J. Gynaecol. Oncol.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Italy

[Number-of-references] 10

   

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OBJECTIVES: To investigate whether pleural levels of the soluble oncoprotein 185 HER-2 (sp185(HER-2)), individually or in combination with CEA and CA 15-3, were useful for the diagnosis of malignant effusions.

DESIGN AND METHODS: Levels of CEA, CA 15-3, and sp185(HER-2) were measured in the pleural fluid from 135 malignant and 103 benign effusions.

Thresholds of these tumor markers were chosen for a diagnostic specificity of >or=99%.

RESULTS: Pleural sp185(HER-2) levels greater than 25 ng/mL were observed in 20% of breast and 10% of lung adenocarcinomas, and predicted a malignant effusion with a sensitivity of 7% and a likelihood ratio of 7.6.

Only 1 patient with breast adenocarcinoma among 45 cytology-negative malignant effusions had sp185(HER-2) above the diagnostic cutoff point.

[MeSH-major] Biomarkers, Tumor / analysis. Pleural Effusion, Malignant / diagnosis. Receptor, ErbB-2 / analysis

[MeSH-minor] Adenocarcinoma / diagnosis. Aged. Breast Neoplasms / diagnosis. Carcinoembryonic Antigen / analysis. False Negative Reactions. Humans. Likelihood Functions. Lung Neoplasms / diagnosis. Male. Middle Aged. Mucin-1 / analysis. Pleural Effusion / chemistry. Pleural Effusion / diagnosis. Sensitivity and Specificity

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(PMID = 15925354.001).

[ISSN] 0009-9120

[Journal-full-title] Clinical biochemistry

[ISO-abbreviation] Clin. Biochem.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Mucin-1; EC 2.7.10.1 / Receptor, ErbB-2

   

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METHODS: A total of 34 adrenalectomies were performed in 32 patients for incidental adrenal masses discovered at primary tumor diagnosis or during follow-up.

The primary tumors diagnosed were 13 cases of lung carcinoma, 9 of renal cell carcinoma, 2 of colorectal carcinoma, 2 of bladder carcinoma, and 1 each of ovarian carcinoma, breast cancer, gastric cancer, and melanoma.

Two patients had no history of a primary tumor.

The male/female ratio was 1.9:1.

The mean tumor size was 4.3 cm (range 1.5 to 9).

The microscopic analysis revealed 22 malign lesions (64.7%) and 12 cases of benign pathologic features (35.3%).

[MeSH-minor] Adult. Female. Humans. Incidental Findings. Male. Middle Aged

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(PMID = 17445640.001).

[ISSN] 1527-9995

[Journal-full-title] Urology

[ISO-abbreviation] Urology

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias.

METHODS: We derived the decision algorithm used in this study from the analysis of serum samples from patients with prostate cancer (n = 181) and benign prostatic hyperplasia (BPH) (n = 143) and normal controls (n = 220).

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[Cites] J Natl Cancer Inst. 2002 Oct 16;94(20):1576-8 [12381711.001]

[Cites] Clin Breast Cancer. 2003 Aug;4(3):203-9 [14499014.001]

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[CommentIn] Clin Chem. 2008 Jan;54(1):3-5 [18160722.001]

[CommentIn] Clin Chem. 2008 Jan;54(1):6-7 [18160723.001]

(PMID = 17981926.001).

[ISSN] 0009-9147

[Journal-full-title] Clinical chemistry

[ISO-abbreviation] Clin. Chem.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA 084986; United States / NCI NIH HHS / CA / CA 84968; United States / NCI NIH HHS / CA / P50 CA058236; United States / NCI NIH HHS / CA / P30 CA006973; United States / NCI NIH HHS / CA / CA 86368; United States / NCI NIH HHS / CA / U01 CA086402; United States / NCI NIH HHS / CA / U01 CA085067; United States / NCI NIH HHS / CA / U01 CA086323; United States / NCI NIH HHS / CA / U24 CA086368; United States / NCI NIH HHS / CA / U01 CA086368; United States / NCI NIH HHS / CA / CA 86359; United States / NCI NIH HHS / CA / CA 86402; United States / NCI NIH HHS / CA / U24 CA086359; United States / NCI NIH HHS / CA / CA 86323; United States / NCI NIH HHS / CA / U01 CA084968; United States / NCI NIH HHS / CA / CA 85067; United States / NCI NIH HHS / CA / U01 CA084986

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor

[Other-IDs] NLM/ NIHMS371877; NLM/ PMC3354530

   

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[Title] PTEN hamartoma tumor syndromes.

The PTEN hamartoma tumor syndromes (PHTS) are a collection of rare clinical syndromes characterized by germline mutations of the tumor suppressor PTEN.

These syndromes are driven by cellular overgrowth, leading to benign hamartomas in virtually any organ.

Cowden syndrome (CS), the prototypic PHTS syndrome, is associated with increased susceptibility to breast, thyroid, and endometrial cancer.

[MeSH-minor] Cell Movement. Cell Proliferation. Cell Survival. Chromosomes, Human, Pair 10 / genetics. Chromosomes, Human, Pair 10 / metabolism. Female. Humans. Male. Phosphatidylinositol 3-Kinases / genetics. Phosphatidylinositol 3-Kinases / metabolism. Protein Kinases / genetics. Protein Kinases / metabolism. Proto-Oncogene Proteins c-akt / genetics. Proto-Oncogene Proteins c-akt / metabolism. Signal Transduction. TOR Serine-Threonine Kinases

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(PMID = 18781191.001).

[ISSN] 1018-4813

[Journal-full-title] European journal of human genetics : EJHG

[ISO-abbreviation] Eur. J. Hum. Genet.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 0 / Antineoplastic Agents; EC 2.7.- / Protein Kinases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase

[Number-of-references] 77

   

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PURPOSE: Cyclin B1-derived peptides were shown by us to be targets of tumor-specific CD8(+) T cells in patients with breast and head and neck cancer.

We obtained further evidence of cyclin B1 immunogenicity and its potential to serve as a tumor-specific antigen by analyzing its ability to elicit T cell-dependent humoral immune responses in vivo in patients with different types of tumors.

EXPERIMENTAL DESIGN: Recombinant cyclin B1 protein from two different sources was purified and used as antigen in ELISA assays to test sera from patients with breast, pancreatic, colon, and lung cancer for the presence of anti-cyclin B1 antibody.

We also analyzed patients with benign lung disease, premalignant disease, and a known history of heavy smoking.

Antibodies in patients with breast and colon cancer are primarily of the IgG isotype whereas patients with pancreatic and lung cancer have in addition anti-cyclin B1 IgA.

[MeSH-minor] Breast Neoplasms / blood. Breast Neoplasms / immunology. Breast Neoplasms / metabolism. Colonic Neoplasms / blood. Colonic Neoplasms / immunology. Colonic Neoplasms / metabolism. Cyclin B1. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunoglobulin A / blood. Immunoglobulin G / blood. Immunohistochemistry. Lung Neoplasms / blood. Lung Neoplasms / immunology. Lung Neoplasms / metabolism. Male. Pancreatic Neoplasms / blood. Pancreatic Neoplasms / immunology. Pancreatic Neoplasms / metabolism. Smoking / immunology

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(PMID = 15746055.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / P50 CA 090440

[Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / CCNB1 protein, human; 0 / Cyclin B; 0 / Cyclin B1; 0 / Immunoglobulin A; 0 / Immunoglobulin G

   

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We investigate thymidine kinase 1 concentration in serum (S-TK1) as a potential tumor marker.

S-TK1 concentration and STK activity levels were determined in 9 human malignant diseases (breast, gastric, rectal, colorectal, lung, brain cancer, hepatoma, lymphoma, leukaemia) and in benign and non-cancerous diseases, representing 850 preoperative cases.

S-TK1 concentrations and STK activity levels in preoperative malignant patients were significantly higher than in healthy individuals, in patients with benign tumors and in those with non-cancerous diseases.

Significant correlations between concentration and activity level were only found in healthy individuals, in patients with benign tumors, and in some patients with malignancies, i.e. leukaemia, and breast and gastric cancers.

We conclude that S-TK1 concentration is a more sensitive tumor marker in solid malignancies than is STK activity.

[MeSH-major] Biomarkers, Tumor. Neoplasms / blood. Neoplasms / diagnosis. Thymidine Kinase / blood

[MeSH-minor] Breast Neoplasms / pathology. Cell Line, Tumor. Cell Proliferation. Dose-Response Relationship, Drug. Female. Humans. Male. Neoplasm Staging. Radioimmunoassay / methods. Stomach Neoplasms / pathology

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(PMID = 16142366.001).

[ISSN] 1021-335X

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Greece

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.1.21 / Thymidine Kinase; EC 2.7.1.21 / thymidine kinase 1

   

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[Title] [Expression and clinical significance of cytokeratin 19 in bone marrow of patients with breast cancer].

BACKGROUND & OBJECTIVE: Breast cancer may undergo metastasis in early phase.

Distant metastasis, especially bone metastasis, may influence prognosis of breast cancer patients.

This study was designed to evaluate expression and clinical significance of cytokeratin 19 (CK19) in bone marrow of patients with breast cancer.

METHODS: Expression of CK19 mRNA in bone marrows of 65 breast cancer patients, 15 benign breast disease patients, and 8 healthy volunteers was detected by reverse transcription-polymerase chain reaction (RT-PCR).

Correlation of CK19 mRNA expression to clinicopathologic features of the 65 breast cancer patients was analyzed.

RESULTS: Positive rate of CK19 mRNA was 33.8% in the 65 breast cancer patients, and 0 in both benign breast disease patients and healthy volunteers.

Expression of CK19 mRNA was positively correlated with tumor size and clinical stage (P < 0.05), but was not related to age and lymph node status (P > 0.05).

CONCLUSIONS: CK19 mRNA may be used as a molecular marker to detect bone marrow micrometastasis in patients with breast cancer.

The detection may help to select proper therapy and predict prognosis of breast cancer patients.

[MeSH-major] Bone Marrow / metabolism. Breast Neoplasms / metabolism. Carcinoma, Ductal, Breast / metabolism. Keratin-19 / biosynthesis

[MeSH-minor] Adult. Aged. Breast Neoplasms, Male / metabolism. Breast Neoplasms, Male / pathology. Carcinoembryonic Antigen / blood. Female. Fibroadenoma / blood. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / biosynthesis. RNA, Messenger / genetics

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(PMID = 15946491.001).

[Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer

[ISO-abbreviation] Ai Zheng

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / RNA, Messenger

   

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Recently, several MMPs were implicated in creating an environment that supports the initiation and maintenance of tumor growth.

Of these patients, 22 had malignant pleural effusion, consisting of 11 breast carcinomas and 11 lung carcinomas (7 squamous cell carcinomas and 4 adenocarcinomas), and 8 patients had benign effusions.

The MMP-9/MMP-2 ratio was enhanced in cancer patients compared with benign diseases and healthy individuals.

[MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / enzymology. Breast Neoplasms / pathology. Carcinoma, Non-Small-Cell Lung / enzymology. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / enzymology. Lung Neoplasms / pathology. Matrix Metalloproteinase 2 / blood. Matrix Metalloproteinase 9 / blood. Pleural Effusion / enzymology. Pleural Effusion / pathology

[MeSH-minor] Adolescent. Adult. Aged. Case-Control Studies. Female. Humans. Male. Middle Aged

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(PMID = 15809729.001).

[ISSN] 1019-6439

[Journal-full-title] International journal of oncology

[ISO-abbreviation] Int. J. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9

   

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[Title] Giant myofibroblastoma of breast: a case report.

Myofibroblastoma of the breast is a very rare benign neoplasm usually seen in elderly male and is of very small size.

A 40 year old nulliparous woman was admitted with chief complain of massive enlargement of left breast.

The case was clinically diagnosed as Phyllodes tumor Left mastectomy was done.

The tumor was histopathologically and immunohistochemically diagnosed as Myofibroblastoma.

[MeSH-major] Breast Neoplasms / diagnosis. Neoplasms, Muscle Tissue / diagnosis

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(PMID = 17883145.001).

[ISSN] 0377-4929

[Journal-full-title] Indian journal of pathology & microbiology

[ISO-abbreviation] Indian J Pathol Microbiol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

   

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BACKGROUND AND AIM: Mammary serine protease inhibitor (Maspin) is down regulated in breast and prostate cancers and is considered as a tumor suppressor gene.

On the contrary, it is over expressed in pancreatic and ovarian carcinomas and is reported to be an oncogene rather than a tumor suppressor gene.

The studies of maspin expression in thyroid neoplasia, the focus of this study, are limited.

We, therefore, carried out this work in order to detect the frequency and pattern of maspin expression in thyroid neoplasia.

MATERIAL & METHODS: An immunohistochemical approach was performed on 63 thyroid specimens showing different benign and malignant thyroid lesions.

There was no statistically significant relation between maspin positive cases and the studied clinicopathological parameters including patient's age, sex and tumor stage.

On the other hand, it was statistically significant as regards tumor multicentricity, vascular and lymphatic invasion, as well as lymph node metastasis.

[MeSH-major] Carcinoma, Papillary / diagnosis. Serpins / analysis. Thyroid Neoplasms / diagnosis

[MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Thyroid Gland / chemistry

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(PMID = 17671538.001).

[ISSN] 1110-0362

[Journal-full-title] Journal of the Egyptian National Cancer Institute

[ISO-abbreviation] J Egypt Natl Canc Inst

[Language] eng

[Publication-type] Journal Article

[Publication-country] Egypt

[Chemical-registry-number] 0 / SERPIN-B5; 0 / Serpins

   

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The tumor cells expressed a T-phenotype (CD3+, CD20-) and were CD30-, CD4-, and CD8-negative.

A diagnosis of localized pagetoid reticulosis (Woringer-Kolopp disease) with possible large cell transformation was proposed.

Reevaluation of the skin lesion and of a tonsil specimen previously interpreted as benign hyperplasia showed features consistent with those observed in the lymph node.

[MeSH-major] Breast Neoplasms, Male / pathology. Lymphatic Diseases / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Nipples / pathology. Paget's Disease, Mammary / pathology

[MeSH-minor] Adult. Antigens, CD3 / analysis. Antigens, CD43 / analysis. Antigens, CD7 / analysis. Fatal Outcome. Humans. Hyperplasia. Lymph Nodes / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Male. Palatine Tonsil / pathology. T-Lymphocytes / pathology

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(PMID = 17667175.001).

[ISSN] 0193-1091

[Journal-full-title] The American Journal of dermatopathology

[ISO-abbreviation] Am J Dermatopathol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD43; 0 / Antigens, CD7

   

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A granular cell tumor (GCT) is relatively uncommon and objectively diagnosed with neural markers on immunohistochemistry (IHC).

Herein, we present morphologic spectrum of 12 GCTs of soft tissues and skin, including 10 benign and 2 malignant subtypes with an optimal diagnostic IHC panel.

Six cases occurred in soft tissues and skin of extremities, 4 in the breast soft tissues, and 1 case each in the back and preauricular region, respectively.

On histopathology, all cases invariably revealed a nonencapsulated infiltrating tumor comprising groups and nests of granular cells with vesicular nuclei.

Immunohistochemistry in 10 cases (83.3%) showed diffuse S-100 positivity in all 7 benign and 2 malignant cases: cytoplasmic CD68 positivity (all 10 cases) and membranous vimentin staining (all 4 cases).

A GCT is a discrete tumor entity and can be identified from other granular lesions by its proximity to nerves and objective identification with diffuse S-100 positivity, CD68 positivity, and membranous vimentin positivity that form an optimal IHC panel in limited resource settings, irrespective of benign or malignant types.

[MeSH-major] Cancer Care Facilities. Granular Cell Tumor / pathology. Referral and Consultation. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

[MeSH-minor] Adult. Aged. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Biomarkers, Tumor / metabolism. Child. Female. Humans. Male. Middle Aged. S100 Proteins / metabolism. Vimentin / metabolism. Young Adult

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(PMID = 20471560.001).

[ISSN] 1532-8198

[Journal-full-title] Annals of diagnostic pathology

[ISO-abbreviation] Ann Diagn Pathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / S100 Proteins; 0 / Vimentin

   

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METHODS: A retrospective study was conducted on all pediatric brain and spinal cord tumor patients operated in a single center from 1999 to 2009.

Details of preoperative treatment, diagnosis and clinical status, postoperative diagnosis, early and late outcomes, progression-free survival and overall survival, and parental satisfaction were reviewed.

In ten cases, radical removal of the tumor resulted in a change in histological diagnosis, usually from a presumed diagnosis of malignancy to a more benign variety (n = 6).

[MeSH-minor] Adolescent. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Male. Retrospective Studies. Treatment Outcome

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[CommentIn] Childs Nerv Syst. 2010 Sep;26(9):1227-8 [20574741.001]

[ErratumIn] Childs Nerv Syst. 2010 Dec;26(12):1833. Charles, Teo [corrected to Teo, Charles]; Morgan, Broggi [corrected to Broggi, Morgan]

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(PMID = 20563727.001).

[ISSN] 1433-0350

[Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

[ISO-abbreviation] Childs Nerv Syst

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

   

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Six patients were male and five were female.

Two lesions each arose on the tongue, upper back and popliteal fossa, and one each on the buccal submucosa, shoulder, breast, lateral chest and sole.

The presented tumor was an early one because of the shortest duration and the smallest size in Japan.

Recent criteria for a benign mesenchymoma including a chondrolipoma were also described.

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(PMID = 16620227.001).

[ISSN] 0385-2407

[Journal-full-title] The Journal of dermatology

[ISO-abbreviation] J. Dermatol.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Japan

[Number-of-references] 18

   

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[Title] Differential expression of TRAIL and its receptors in benign and malignant prostate tissues.

PURPOSE: Because TRAIL (tumor necrosis factor related apoptosis inducing ligand) selectively kills cancer cells without damaging normal cells, a gene therapy approach using TRAIL is feasible for treating patients with cancer.

Our recent studies suggest that TRAIL receptor composition is the major modulator of TRAIL sensitivity, as demonstrated using prostate, breast and lung cancer cells.

MATERIALS AND METHODS: Paraffin embedded prostate tissues of 44 patients with benign prostatic hyperplasia, 28 with organ confined prostate carcinoma and 26 with advanced prostate carcinoma were analyzed using immunohistochemical staining procedures.

RESULTS: Significant levels of TRAIL-R4 decoy receptor expression were detected in patients with benign prostatic hyperplasia, and organ confined and advanced prostate carcinoma.

All TRAIL markers tested appear to be valuable markers for separating patients with benign prostatic hyperplasia from patients with organ confined prostate carcinoma or advanced prostate carcinoma.

[MeSH-minor] Humans. Immunohistochemistry. Male

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(PMID = 17162091.001).

[ISSN] 0022-5347

[Journal-full-title] The Journal of urology

[ISO-abbreviation] J. Urol.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / TNF-Related Apoptosis-Inducing Ligand

   

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[Title] [Desmoid tumor in a male breast in the context of Gardner's syndrome. Case report].

[Transliterated title] Tumeur desmoïde du sein chez l'homme dans le cadre d'un syndrome de Gardner. A propos d'un cas.

Fibromatosis (Desmoid tumor) of the male breast is an exceptional location.

We present a case of such a tumor, in the context of Gardner's syndrome.

A palpable mass was discovered in the right breast of a 52 years old man, with a history of rectocolic adenomatous polyposis.

Mammography ant thoracic CT scan showed a stellar tumor, mimicking a breast cancer.

Treatment consisted of wide excision and histology revealed a desmoid tumor.

Desmoid tumors of the breast are benign lesions; they should be widely excised because of a high risk of recurrence.

Coloscopy is indicated in the presence of mammary fibromatosis, to look for associated multiple polyps, confirming the diagnosis of Gardner's syndrome.

[MeSH-major] Breast Neoplasms, Male / pathology. Breast Neoplasms, Male / surgery. Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / surgery. Gardner Syndrome / complications

[MeSH-minor] Colonoscopy. Humans. Male. Middle Aged. Risk Factors. Tomography, X-Ray Computed

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(PMID = 15664376.001).

[ISSN] 0003-3944

[Journal-full-title] Annales de chirurgie

[ISO-abbreviation] Ann Chir

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

   

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We describe the development of a carcinoma originating from thymic hyperplasia and followed by the formation of a benign tumour composed chiefly of medullary epithelial cells expressing the transgene and of lymphocytes, a pathology very rarely reported in mice.

[MeSH-major] Antigens, Polyomavirus Transforming / genetics. Antigens, Viral, Tumor / genetics. Neovascularization, Pathologic. Promoter Regions, Genetic. Pyruvate Kinase / genetics. Thymus Neoplasms / pathology

[MeSH-minor] Animals. Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic. Female. Immunohistochemistry / methods. Male. Mice. Mice, Inbred CBA. Mice, Transgenic. Microscopy, Immunoelectron. Thymus Gland / pathology

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(PMID = 16309545.001).

[ISSN] 0959-9673

[Journal-full-title] International journal of experimental pathology

[ISO-abbreviation] Int J Exp Pathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Antigens, Polyomavirus Transforming; 0 / Antigens, Viral, Tumor; 0 / Biomarkers, Tumor; EC 2.7.1.40 / Pyruvate Kinase

[Other-IDs] NLM/ PMC2517450

   

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CONCLUSION: Mammary fibromatosis is a rare, benign, nonmetastasizing stromal tumor.

It presents clinically and radiologically as a palpable, spiculated, and locally invasive tumor that is suspicious for malignancy.

Although histologically benign, the tumor is locally aggressive and has significant recurrence rates.

[MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms, Male / diagnosis. Fibroma / diagnosis

[MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Ultrasonography, Mammary

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(PMID = 19696302.001).

[ISSN] 1546-3141

[Journal-full-title] AJR. American journal of roentgenology

[ISO-abbreviation] AJR Am J Roentgenol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] [Diagnosis and therapy of childhood thyroid carcinoma: clinical analysis of 12 cases].

OBJECTIVE: To explore the clinical characteristics, diagnosis and therapy of thyroid carcinoma in children.

RESULTS: A hard thyroid mass was observed in 10 out of 12 children with thyroid carcinoma, but only one out of 15 children with benign thyroid tumor (<0.05).

The rate of cervical lymph node metastasis in children with thyroid carcinoma was significantly higher than that in children with benign thyroid tumor (<0.05).

A combination of ultrasonography and CT is helpful to the diagnosis of childhood thyroid carcinoma.

[MeSH-major] Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery

[MeSH-minor] Adolescent. Child. Female. Follow-Up Studies. Humans. Iodine Radioisotopes / therapeutic use. Male. Postoperative Complications / etiology. Tomography, X-Ray Computed

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(PMID = 19222949.001).

[ISSN] 1008-8830

[Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Iodine Radioisotopes

   

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[Title] Secondary neoplasms after radiotherapy for a childhood solid tumor.

This study was conducted to determine the outcome of patients who develop a second neoplasm after radiotherapy (RT) for a childhood solid tumor.

From 1956 to 1998, 429 children with a malignant solid tumor were treated at a single radiation oncology facility.

The medical records and radiotherapy charts were reviewed to determine if the patient developed a secondary neoplasm after treatment for malignancy.

Twenty-three (5.4%) patients developed a secondary neoplasm.

There were 14 malignant neoplasms in 13 (3.0%) and 14 benign neoplasms in 11 patients (2.6%).

The types of initial solid tumors treated with RT were Ewing sarcoma in 6, Wilms tumor in 6, medulloblastoma in 5, neuroblastoma in 3, and other in 3.

For the 14 malignant neoplasms, the median time interval from initial tumor to second malignancy was 10.1 years.

The 14 second malignant neoplasms (SMN) were osteosarcoma in 3, breast carcinoma in 2, melanoma in 2, malignant fibrous histiocytoma in 1, dermatofibrosarcoma in 1, leiomyosarcoma in 1, mucoepidermoid carcinoma in 1, colon cancer in 1, chronic myelogenous leukemia in 1, and basal cell carcinoma in 1.

The 5- and 10-year overall survival rate after diagnosis of an SMN was 69.2%; it was 70% for children with a SMN at the edge or inside the RT field and 66.7% for those outside of the RT field.

The 14 benign neoplasms appeared at a median time of 16.9 years and included cervical intraepithelial neoplasia in 3, osteochondroma in 3, thyroid adenoma in 1, duodenal adenoma in 1, lipoma in 1, cherry angioma in 1, uterine leiomyoma in 1, ovarian cystadenofibroma in 1, and giant cell tumor in 1.

Only 5 (36%) of the 14 benign tumors occurred in the RT field, with osteochondroma being the most common.

More than two-thirds of children with a radiation-induced malignancy are alive 10 years after the diagnosis of a SMN.

[MeSH-minor] Adolescent. Adult. Cause of Death. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Radiation Dosage. Retrospective Studies. Survival Rate

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(PMID = 15804994.001).

[ISSN] 0888-0018

[Journal-full-title] Pediatric hematology and oncology

[ISO-abbreviation] Pediatr Hematol Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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There has been strong evidence that the metabolism of thyroid hormones is disturbed in some neoplastic tissues such as thyroid, renal, and breast cancer.

However, there are few available data about D1 enzyme activity in benign tumors such as hemangioma, which is the most common primary liver tumor.

These finding demonstrate a low enzymatic activity of D1 in liver hemangioma and suggest an as yet unknown role of thyroid hormones in this type of benign liver tumor.

[MeSH-minor] Adult. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged

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(PMID = 20049650.001).

[ISSN] 1661-4917

[Journal-full-title] Archivum immunologiae et therapiae experimentalis

[ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)

[Language] eng

[Publication-type] Journal Article

[Publication-country] Switzerland

[Chemical-registry-number] EC 1.11.1.- / iodothyronine deiodinase type I; EC 1.11.1.8 / Iodide Peroxidase

[Other-IDs] NLM/ PMC2816262

   

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Large cell calcifying Sertoli cell tumor of the testicle is a rare, hormonally active sex cord-stromal tumor seen in patients with Carney complex.

The availability of specific antiestrogen drugs means that bilateral orchiectomy for this benign tumor may no longer be warranted.

Approximately two thirds of teenaged boys will develop some degree of breast enlargement that spontaneously regresses as testosterone levels rise (Ill Med J 1938;73:113).

Disorders of the breast.

[MeSH-major] Multiple Endocrine Neoplasia / diagnosis. Sertoli Cell Tumor / therapy. Testicular Neoplasms / therapy

[MeSH-minor] Child. Gynecomastia / complications. Gynecomastia / therapy. Humans. Male

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(PMID = 17848226.001).

[ISSN] 1531-5037

[Journal-full-title] Journal of pediatric surgery

[ISO-abbreviation] J. Pediatr. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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METHODS: Surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI) and antibody arrays were used to compare protein expression in 21 pairs of gastric cancer tissue and adjacent normal mucosa and serum from 51 gastric cancer patients and 29 patients with benign gastric diseases.

Macrophage migration inhibitory factor (MIF) was increased five-fold (P=1.84 x 10(-7)) in the serum of gastric cancer patients relative to individuals with benign gastric disease.

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(PMID = 19550422.001).

[ISSN] 1532-1827

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] ENG

[Grant] United Kingdom / Cancer Research UK / /

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins; 0 / Macrophage Migration-Inhibitory Factors; 0 / Neoplasm Proteins; 0 / alpha-Defensins; 0 / human neutrophil peptide 1; 0 / human neutrophil peptide 2; 0 / human neutrophil peptide 3

[Other-IDs] NLM/ PMC2720195

   

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[Title] Solitary fibrous tumor of the breast and mammary myofibroblastoma: the same lesion?

Benign stromal tumors of the breast are rare mesenchymal neoplasms that have significant clinical and morphologic overlap.

We report the case of a spindle cell tumor occurring in the mammary gland with mixed features of solitary fibrous tumor and mammary myofibroblastoma.

[MeSH-major] Breast Neoplasms, Male / pathology. Neoplasms, Muscle Tissue / pathology. Solitary Fibrous Tumors / pathology

[MeSH-minor] Aged. Humans. Male

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(PMID = 18384484.001).

[ISSN] 1524-4741

[Journal-full-title] The breast journal

[ISO-abbreviation] Breast J

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] United States

[Number-of-references] 26

   

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A total of 30 patients with pathologically proven NSCLC were enrolled in this study in addition to ten normal controls subjects and ten cases with benign pulmonary diseases as broncheicatsis, chronic obstructive pulmonary disease.

The levels were significantly higher in those with stages III, IV compared with I, II, and in those with higher grades of the tumor.

[MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / diagnosis. Lung Neoplasms / diagnosis. Receptor, Epidermal Growth Factor / blood. Receptor, ErbB-2 / blood

[MeSH-minor] Aged. Bronchoalveolar Lavage Fluid / chemistry. Female. Humans. Male. Middle Aged. Prognosis

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(PMID = 19093231.001).

[ISSN] 1357-0560

[Journal-full-title] Medical oncology (Northwood, London, England)

[ISO-abbreviation] Med. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2

   

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[Title] Human kallikrein 10 ELISA development and validation in breast cancer sera.

There is significant interest in measuring hK10 which may act as a tumor suppressor in some cancers.

We have developed an ELISA for hK10 and determined its analytical and clinical performance in normal and breast cancer sera.

The assay was analytically validated and used to determine serum levels of hK10 in a set of breast cancer, benign breast disease and normal samples.

Concentrations were not age related and were not significantly different from benign fibrocystic disease or breast cancer.

However, in a subset of breast cancer patients with both early and late stage disease, serum hK10 levels were elevated, at >1.55 ng/mL, above all normal female and benign disease samples.

CONCLUSIONS: We report in detail the analytical performance of a colorimetric hK10 ELISA validated in human serum and report for the first time the hK10 serum concentration in benign and breast cancer samples.

[MeSH-major] Breast Neoplasms / blood. Enzyme-Linked Immunosorbent Assay / methods. Kallikreins / blood

[MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Reproducibility of Results

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(PMID = 17585892.001).

[ISSN] 0009-9120

[Journal-full-title] Clinical biochemistry

[ISO-abbreviation] Clin. Biochem.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] EC 3.4.21.- / KLK10 protein, human; EC 3.4.21.- / Kallikreins