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1. Weaver J, Rao P, Goldblum JR, Joyce MJ, Turner SL, Lazar AJ, López-Terada D, Tubbs RR, Rubin BP: Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol; 2010 Oct;23(10):1301-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Well-differentiated liposarcoma/atypical lipomatous tumor can be difficult to differentiate from benign lipomatous tumors, especially on limited biopsy material.
  • Adjunctive tests for MDM2 (murine double minute 2) have proven useful in whole-tissue sections; however, their utility has not been determined within the increasingly popular core needle biopsy.
  • Herein, we compare the ability of MDM2 immunohistochemistry and MDM2 fluorescence in situ hybridization (FISH) to discriminate benign lipomatous tumors from well-differentiated liposarcoma on core needle biopsies.
  • Well-differentiated liposarcoma (n=17) and an assortment of benign lipomatous tumors (n=37), which had concurrent or previous core needle biopsies, and resection specimens were subjected to both MDM2 immunohistochemistry and MDM2 FISH on both whole-tissue sections and corresponding core needle biopsy sections.
  • Percentage tumor cells positive for MDM2 by immunohistochemistry and an MDM2:CEP12 FISH ratio was calculated in each biopsy and resection specimen pair and the results were compared.
  • The average MDM2:CEP12 ratio was similar in the biopsy material compared with the whole-tissue sections in both well-differentiated liposarcoma and the benign lipomatous tumor group of neoplasms.
  • Detection of MDM2 amplification by FISH is a more sensitive and specific adjunctive test than MDM2 immunohistochemistry to differentiate well-differentiated liposarcoma from various benign lipomatous tumors, especially on limited tissue samples.
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy, Needle. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / biosynthesis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Lipoma / diagnosis. Sensitivity and Specificity

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  • (PMID = 20495536.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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2. Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA: C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Genes Chromosomes Cancer; 2010 Sep;49(9):810-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid lipoma, a rare benign adipose tissue tumor, may histologically resemble myxoid liposarcoma or extraskeletal myxoid chondrosarcoma, but is genetically distinct.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20607705.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA036727-24S59009; United States / NCI NIH HHS / CA / 5 P30 CA036727-2452; United States / NCI NIH HHS / CA / P30 CA036727-24S59009; United States / NCI NIH HHS / CA / U-10-CA98543-091
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MKL2 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Transcription Factors
  • [Other-IDs] NLM/ NIHMS203810; NLM/ PMC2904421
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3. de Vreeze RS, Koops W, Haas RL, van Coevorden F: An unusual case of hemosiderotic fibrohistiocytic lipomatous lesion: correlation of MRI and pathologic findings. Sarcoma; 2008;2008:893918

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual case of hemosiderotic fibrohistiocytic lipomatous lesion: correlation of MRI and pathologic findings.
  • The spectrum of lipomatous lesions ranges from benign to highly malignant disease.
  • Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) is a rare subtype of lipomatous tumor.
  • The diagnosis is usually based on clinical, histological, and immunohistochemical information.

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  • (PMID = 18584051.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2435605
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4. Weaver J, Downs-Kelly E, Goldblum JR, Turner S, Kulkarni S, Tubbs RR, Rubin BP, Skacel M: Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol; 2008 Aug;21(8):943-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms.
  • Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas, respectively.
  • Identifying MDM2 amplification by fluorescence in situ hybridization may prove an adjunctive tool in the diagnosis of lipomatous neoplasms.
  • Dual color fluorescence in situ hybridization employing a laboratory-developed BAC label probe cocktail specific for MDM2 (12q15) and a probe for the centromeric region of chromosome 12 (Abbott Molecular, DesPlaines, IL) was performed on formalin-fixed and paraffin-embedded tissue including whole sections from atypical lipomatous tumors (n=13), dedifferentiated liposarcomas (n=14), benign lipomatous tumors (n=30), and pleomorphic sarcoma, not otherwise specified (n=10), and a tissue microarray containing a variety of high-grade sarcomas (n=63).
  • MDM2/chromosome 12 fluorescence in situ hybridization is a sensitive and specific tool (both 100%) in evaluating low-grade lipomatous neoplasms.
  • Importantly, none of the benign lipomatous lesions were MDM2 amplified and even cells in areas of well-differentiated liposarcomas with minimal cytologic atypia were amplified, making the probe a valuable tool in the diagnosis of even limited biopsy samples of well-differentiated lipomatous neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Lipoma / genetics. Liposarcoma / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Aneuploidy. Chromosomes, Human, Pair 12. Gene Amplification. Humans. Nucleic Acid Amplification Techniques. Tissue Array Analysis

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  • (PMID = 18500263.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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5. Jung SM, Chang PY, Luo CC, Huang CS, Lai JY, Hsueh C: Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan. Pediatr Surg Int; 2005 Oct;21(10):809-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma/lipoblastomatosis is an uncommon benign lipomatous tumor affecting mainly infants and children.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16180007.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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6. Yalniz E, Alicioglu B, Oz Puyan F: Hibernoma: a benign lipomatous tumor mimicking liposarcoma. J BUON; 2008 Jan-Mar;13(1):127-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hibernoma: a benign lipomatous tumor mimicking liposarcoma.
  • Hibernoma is a rare, benign, slow-growing soft tissue tumor.
  • Due to its rich vascularity and magnetic resonance appearance, this tumor may mimic a liposarcoma before tissue diagnosis.
  • The clinical presentation, radiographic and histopathologic features of this rare benign soft tissue tumor are presented.
  • This tumor is clinically important because it is indistinguishable from malignant lesions.
  • [MeSH-major] Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18404800.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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7. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • Histologically, a proliferation of mature adipocytes, ropey collagen fibers and spindle cells within a myxoid stroma was present in the subcutaneous tissue and infiltrated between skeletal muscle fibers.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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8. Kondo T: A case of lipomatous pleomorphic adenoma in the parotid gland: a case report. Diagn Pathol; 2009;4:16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of lipomatous pleomorphic adenoma in the parotid gland: a case report.
  • INTRODUCTION: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands.
  • Extensive lipomatous involvement of the tumor is, however, a very rare finding.
  • CASE REPORT: Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.
  • CONCLUSION: This is the sixth case of lipomatous pleomorphic adenoma in the English literature.
  • Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management.

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  • (PMID = 19497106.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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9. Kuhnen C, Mentzel T, Lehnhardt M, Homann HH, Sciot R, Debiec-Rychter M: [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition]. Pathologe; 2010 Mar;31(2):129-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition].
  • [Transliterated title] Lipom und atypischer lipomatöser Tumor innerhalb einer Neoplasie: Hinweis für einen kontinuierlichen Ubergang.
  • The case of a lipomatous tumor with a predominant lipoma component and transition to an atypical lipomatous tumor is presented.
  • A deep-seated soft tissue tumor of the right thigh with a maximum size of 14 cm was resected in a 70-year-old female patient.
  • In the remaining portion (approximately 20%) histopathology showed an atypical lipomatous tumor (ALT, lipoma-like subtype).
  • Interphase dual-color fluorescence in situ hybridization showed no amplification of the MDM 2 gene and rarely CDK4 gene amplification within the lipoma component, but high level amplification of MDM 2/CDK4 gene in the ALT area, further supporting the morphologically based diagnosis of a lipomatous tumor including areas of a true lipoma and ALT.
  • This case underlines the concept of a continuous stepwise development of lipomatous soft tissue tumors from benign to malignant counterparts as a biological continuum.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. In Situ Hybridization, Fluorescence. Proto-Oncogene Proteins c-mdm2 / genetics. Thigh

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  • (PMID = 20063101.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.3.2.27 / MDM2 protein, human; EC 2.3.2.27 / Proto-Oncogene Proteins c-mdm2; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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10. Gurel D, Kargi A, Lebe B: Pedunculated cutaneous spindle cell/pleomorphic lipoma. J Cutan Pathol; 2010 Sep;37(9):e57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell/pleomorphic lipoma is an infrequently seen benign adipose tissue tumor.
  • This tumor, mostly arising from the subcutaneous tissue, usually affects male patients and occurs in back, shoulders, head and neck area.
  • [MeSH-minor] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Dermis / pathology. Humans. Male. Vimentin / metabolism

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  • (PMID = 19678825.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Vimentin
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11. McQueen C, Montgomery E, Dufour B, Olney MS, Illei PB: Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol; 2010 Jan;17(1):38-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant hypopharyngeal atypical lipomatous tumor.
  • Microscopically, they display an admixture of fibrovascular and adipose tissue that is coated by unremarkable squamous mucosa.
  • Here, we report a case that had scattered hyperchromatic cells and lipoblasts within the adipose tissue component.
  • In other anatomic sites similar appearing lesions have been interpreted as pedunculated liposarcomas/atypical lipomatous tumors that are more prone to local recurrences than classic giant fibrovascular polyps.
  • To confirm our suspicion of liposarcomatous differentiation, we performed immunohistochemistry for MDM2 and p53, 2 markers that are known to be negative in benign lipomatous lesions and positive in well-differentiated liposarcomas/atypical lipomatous tumors.
  • The scattered atypical hyperchromatic cells and the lipoblasts both exhibited strong nuclear staining for both markers and supported the diagnosis of pedunculated giant hypopharyngeal atypical lipomatous tumor.
  • [MeSH-minor] Humans. Immunohistochemistry. Male. Middle Aged. Polyps / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20032637.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 51
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12. Prayson RA: Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation. Ann Diagn Pathol; 2009 Feb;13(1):36-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation.
  • Cases of cerebral neuroblastoma or supratentorial primitive neuroectodermal tumor with malignant gliomatous components are relatively uncommon.
  • This is a case report of a lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation occurring in a 48-year-old woman.
  • These cells were arranged against a benign lipomatous background.
  • The second resection consisted primarily of glioblastomatous-like tissue with intermixed lipomatous component.
  • The glioblastomatous component of the tumor demonstrated glial fibrillary acidic protein immunoreactivity.

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  • (PMID = 19118780.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Synaptophysin
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13. Kurkcuoglu IC, Demircan S, Kurul IC, Demirag F: Endobronchial lipomatous hamartoma. Asian Cardiovasc Thorac Ann; 2005 Dec;13(4):372-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endobronchial lipomatous hamartoma.
  • Pulmonary hamartomas are the most common benign neoplasm of the lung, occurring in the parenchyma or sometimes within the bronchi.
  • Reported is a case of a 64-year-old male patient with an endobronchial tumor.

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  • (PMID = 16304229.001).
  • [ISSN] 0218-4923
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Mioulet D, Paule P, Roche NC, Gil JM, Hubert S, Fourcade L: [Lipomatous hypertrophy of the interatrial septum]. Ann Cardiol Angeiol (Paris); 2010 Apr;59(2):111-3
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  • [Title] [Lipomatous hypertrophy of the interatrial septum].
  • Lipomatous hypertrophy of the heart is a benign rare tumor characterized by fatty tissue deposits in the interatrial septum.
  • Its diagnosis during life is mostly seen incidental.
  • The diagnosis of lipomatous hypertrophy of the interatrial septum is confirmed by MRI, which shows a well limited and not encapsulated tumor, appearing in increased signal density on T1-weighted images, and that decreases with fat-saturated sequences.
  • This tumor did not enhance with the administration of contrast material.
  • The benign and lipomatous nature of the lesion is confirmed, thus making the use of histology unnecessary.

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  • (PMID = 19962689.001).
  • [ISSN] 1768-3181
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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15. Châtillon CE, Guiot MC, Jacques L: Lipomatous, vascular, and chondromatous benign tumors of the peripheral nerves: representative cases and review of the literature. Neurosurg Focus; 2007;22(6):E18
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  • [Title] Lipomatous, vascular, and chondromatous benign tumors of the peripheral nerves: representative cases and review of the literature.
  • Benign peripheral nerve lesions of lipomatous, vascular, and chondromatous origin are very rare.
  • Only one previous case of brachial plexus involvement by such a tumor has been reported.

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  • (PMID = 17613209.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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16. Kazakov DV, Sima R, Michal M: Hemosiderotic fibrohistiocytic lipomatous lesion: clinical correlation with venous stasis. Virchows Arch; 2005 Jul;447(1):103-6
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  • [Title] Hemosiderotic fibrohistiocytic lipomatous lesion: clinical correlation with venous stasis.
  • Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) is a recently proposed lipomatous entity.
  • HFLL was originally suggested to be a benign reactive lesion arising due to an antecedent trauma.
  • We hypothesize that the proliferation of spindled fibroblastic and myofibroblastic cells and capillaries, erythrocyte extravasation, and hemosiderin deposition with lipomatous tissue of HFLL may simply represent an exaggerated tissue response to venous stasis in which elevated venous and capillary pressures, oxygen saturation, and edema stimulate the proliferation of the above mentioned elements and lead to erythrocyte extravasation.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytosis / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology. Varicose Veins / pathology. Venous Insufficiency / pathology
  • [MeSH-minor] Adipose Tissue / chemistry. Adipose Tissue / pathology. Biomarkers, Tumor / analysis. Female. Hemosiderin / analysis. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome

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  • [Cites] Lab Invest. 1982 Jul;47(1):43-50 [7087397.001]
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  • (PMID = 15947948.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9011-92-1 / Hemosiderin
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17. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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18. Nilsson M, Domanski H, Mertens F, Mandahl N: Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12. Oncol Rep; 2005 Apr;13(4):649-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.
  • Atypical lipomatous tumor (ALT), an intermediate malignant neoplasm of soft tissues, is characterized by the presence of supernumerary ring and giant marker chromosomes.
  • These findings are consistent with previous reports that the ALT phenotype may be associated with a low or moderate level of gene amplification, whereas truncation of HMGA2 has been observed in both ALTs and benign lipomas.
  • Whether ALTs with these types of aberrations have a lower risk of tumor progression than ALTs with the notoriously mitotically unstable ring and giant marker chromosomes remains to be investigated.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 8. Lipoma / genetics. Lipoma / pathology. Neoplasms, Adipose Tissue / genetics. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 15756437.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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19. Cao D, Srodon M, Montgomery EA, Kurman RJ: Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature. Int J Gynecol Pathol; 2005 Apr;24(2):196-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature.
  • Angiomyofibroblastoma (AMF) is a rare, benign, mesenchymal tumor occurring mainly in the female genital tract.
  • Some cases contain scattered mature adipocytes, but the lipomatous variant in which mature adipose tissue is prominent or striking is rare.
  • We report two more such cases that were composed of 70 to 80% and 30 to 40% adipose tissue, respectively.
  • Immunohistochemical analysis showed that the tumor cells were positive for estrogen receptor, progesterone receptor, vimentin, and Bcl-2, and negative for cytokeratin AE1/1, EMA, and CD117.
  • Tumor cells in the first case were positive for CD34 but not desmin and muscle-specific actin.
  • The opposite expression profile of these three markers was observed in tumor cells in the second case: positive for desmin and muscle-specific actin and negative for CD34.
  • Rare cells were positive for S-100 in adipose-rich areas in the first case.
  • Our findings indicate that the tumor cells in the lipomatous variant have similar immunoprofile to those of usual AMF and support the concept that the lipomatous variant probably represents an extreme end of a wide spectrum of differentiation in AMF.
  • [MeSH-minor] Adipose Tissue / metabolism. Adipose Tissue / pathology. Adult. Biomarkers, Tumor. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Myxoma / pathology

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  • (PMID = 15782077.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Colnat-Coulbois S, Kremer S, Weinbreck N, Pinelli C, Auque J: Lipomatous meningioma: report of 2 cases and review of the literature. Surg Neurol; 2008 Apr;69(4):398-402; discussion 402
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  • [Title] Lipomatous meningioma: report of 2 cases and review of the literature.
  • BACKGROUND: Lipomatous meningioma is a rare but, most of the time, benign tumor.
  • Its pathogenesis is still debated: it is usually considered to be part of the metaplastic meningioma, but several authors recently suggested that fat accumulation inside the tumor was related to metabolic disorders of the meningothelial cells.
  • CASES DESCRIPTION: We report 2 cases of lipomatous meningioma.
  • Radiological features depended on the amount of fat accumulation within the tumor.
  • CONCLUSION: Our study strongly suggests that lipomatous meningioma results from an accumulation of lipid inside meningothelial cells rather than a true metaplasia.

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  • (PMID = 17825370.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipids
  • [Number-of-references] 16
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21. Scariot R, Giovanini AF, Torres-Pereira CC, Piazzetta CM, Costa DJ, Rebellato NL, Müller PR: Massive growth of an intraoral lipoma. J Contemp Dent Pract; 2008;9(7):115-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Lipoma, a benign tumor of adipose tissue, is rarely seen in the oral cavity.
  • A clinical diagnosis of lipoma was established, and the treatment consisted of complete excision of the mass under local anesthesia.
  • CLINICAL SIGNIFICANCE: This case report emphasizes the slow growth and benign characteristics of oral lipomas.

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  • (PMID = 18997924.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Prud'homme A, Rousselot C, de Pinieux G, Voche P, Rosset P: [Hemosiderotic fibrohistiocytic lipomatous lesion: a new entity you must remind]. Ann Chir Plast Esthet; 2007 Dec;52(6):616-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hemosiderotic fibrohistiocytic lipomatous lesion: a new entity you must remind].
  • Fatty tissues lesions are the most frequent of both benign (lipoma) and malignant tumor (liposarcoma) of soft tissues in the adult.
  • We here describe the case of female patient having a fatty tissue mass of the ankle corresponding to an hemosiderotic fibrohistiocytic lipomatous lesion (HFHLL).
  • This very rare tumour of recent description is specific of the ankle/foot area of the middle age women.
  • These lesions are always benign and frequently recur following incomplete resection.
  • This tumor may have invasive local growth and metastases have not been described so far.
  • We discuss the main differentials diagnosis and treatment.
  • [MeSH-major] Hemosiderosis / complications. Histiocytic Disorders, Malignant / complications. Histiocytic Disorders, Malignant / pathology. Leiomyoma / complications. Leiomyoma / pathology. Lipoma / complications. Lipoma / pathology. Neoplasms, Adipose Tissue / complications. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 17316948.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. Yamaguchi T, Takimoto T, Yamashita T, Kitahara S, Omura M, Ueda Y: Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney. Urology; 2005 Jan;65(1):175
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  • [Title] Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney.
  • Fat-containing variant of a solitary fibrous tumor is a recently recognized benign soft-tissue tumor that usually affects the thigh and retroperitoneum.
  • We report a 51-year-old woman with a fat-containing variant of a solitary fibrous tumor that is the first reported case involving a visceral organ.
  • The tumor was well delineated and seemed to arise from the renal capsule, radiographically and macroscopically.
  • The tumor microscopically mimicked a solitary fibrous tumor but exhibited focal aggregates of fat cells.
  • A fat-containing variant of a solitary fibrous tumor involving the kidney should be distinguished from spindle cell carcinoma, angiomyolipoma, gastrointestinal stromal tumor, and cellular schwannoma.
  • [MeSH-major] Adipose Tissue / pathology. Hemangiopericytoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 15667897.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Jakobiec FA, Nguyen J, Bhat P, Fay A: MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):413-5
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  • [Title] MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit.
  • PURPOSE: To distinguish, in a 36-year-old man, an atypical lipomatous neoplasm/well-differentiated liposarcoma from a spindle cell lipoma in a recurrent orbital tumor.
  • RESULTS: MDM2 gene amplification was discovered in the CD34 tumor cells.
  • These findings established the diagnosis of a well-differentiated liposarcoma with lipoma-like and spindle cell features and ruled out a spindle cell lipoma.
  • CONCLUSION: Well-differentiated liposarcoma is a slow growing, infiltrative, and nonmetastasizing neoplasm that is microscopically and diagnostically challenging.
  • It can be reliably separated from a benign spindle cell or an atypical lipoma by using the markers MDM2 and Ki-67.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbital Neoplasms / diagnosis. Proto-Oncogene Proteins c-mdm2 / analysis

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  • (PMID = 20639786.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 9013-56-3 / Factor XIII; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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25. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Lee HW, Han SS, Kang J, Lee MW, Choi JH, Moon KC, Koh JK: Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? J Cutan Pathol; 2006 Apr;33(4):323-6
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  • [Title] Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor?
  • Eccrine angiomatous hamartoma (EAH) is a rare, benign condition characterized histologically by increased numbers of eccrine elements, as well as numerous capillary channels.
  • We report a 35-year-old female patient with multiple, sudoriparous, subcutaneous nodules on the right foot, which showed typical histopathological findings of EAH, and vascular components of the tumor consisted of thin-walled dilated vascular spaces intermixed with spindle cells and some histiocytoid endothelial cells representing spindle cell hemangioma (SCH).
  • [MeSH-major] Eccrine Glands / pathology. Foot. Hamartoma / diagnosis. Hemangioma / diagnosis. Neoplasms, Connective and Soft Tissue / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lipoma / diagnosis

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  • (PMID = 16630186.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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27. Akbulut M, Zekioglu O, Terek MC, Ozdemir N: Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor. Arch Gynecol Obstet; 2008 Sep;278(3):283-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor.
  • OBJECTIVE: Adenofibroma is a form of mixed mesodermal tumor in which epithelial and stromal components are benign, and usually arises in the endometrium of postmenopausal women.
  • We report a case of lipoadenofibroma of the endometrium that appeared as an intracavitary mass, which is very unusual because endometrioid adenofibroma rarely contains mature adipose tissue, only the second such case described in detail.
  • The endometrial polypoid mass was found to be a lipoadenofibroma composed predominantly of collagenated fibrous stroma populated by cystically dilated and occasionally crowded glands lined with proliferative endometrium, intermingled with abundant mature adipose tissue.
  • CONCLUSION: We suggest that uterine adenofibromas with lipomatous areas belong to the family of mixed tumor of Mullerian origin.
  • [MeSH-major] Adenofibroma / pathology. Endometrial Neoplasms / pathology. Mixed Tumor, Mullerian / pathology

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  • (PMID = 18236054.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Ruiz E, Pozo P, Toselli L, Fernández M, Christiansen S, Lambertini R: Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma. Urology; 2008 Jun;71(6):1067-9
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  • [Title] Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma.
  • A 6-month-old boy presented with an asymptomatic, right intrascrotal mass whereby the testicle was surrounded by a friable lipomatous tumor.
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Male

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  • (PMID = 18538690.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Kern MA, Kasper HU, Drebber U, Guntinas-Lichius O, Veelken F, Ortmann M: [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component]. Laryngorhinootologie; 2005 Jun;84(6):432-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component].
  • Myoepitheliomas of the salivary glands are rare benign tumors composed of spindle-shaped myoepithelial cells, but may show plasmacytoid, epitheloid and clear cell-types that principally exhibit myoepithelial but not ductal differentiation.
  • Lipomatosis in the form of isolated small islands or scattered single lipocytes, is quite uncommon, and a large amount of adipose tissue in a pleomorphic adenoma and myoepithelioma is a rarity and only described in major salivary glands.
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male

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  • (PMID = 15940575.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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30. Moretti VM, de la Cruz M, Brooks JS, Lackman RD: Early pleomorphic hyalinizing angiectatic tumor: precursor or distinct lesion? Orthopedics; 2010 Jul;33(7):516

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early pleomorphic hyalinizing angiectatic tumor: precursor or distinct lesion?
  • Early pleomorphic hyalinizing angiectatic tumor is a rare and recently described soft tissue lesion.
  • Originally believed to be a precursor lesion to neoplastic pleomorphic hyalinizing angiectatic tumor, and possibly identical to hemosiderotic fibrohistiocytic lipomatous lesion/tumor, there have been recent suggestions that it is distinct from pleomorphic hyalinizing angiectatic tumor and is instead a reactive process.
  • This article reports a case of a mass in the foot of a 45-year-old woman, which is 1 of only 15 published cases of early pleomorphic hyalinizing angiectatic tumor and is the first case to describe its radiographic appearance.
  • Early pleomorphic hyalinizing angiectatic tumor predominantly develops in the fourth to sixth decades (average age, 45 years, range, 10-67 years).
  • Forty-four percent of resected lesions recur locally, but no early pleomorphic hyalinizing angiectatic tumor lesion has ever metastasized.
  • These clinical characteristics of early pleomorphic hyalinizing angiectatic tumors closely mirror those of hemosiderotic fibrohistiocytic lipomatous lesions/tumors and are dissimilar to those for classic pleomorphic hyalinizing angiectatic tumors.
  • Therefore, although the 3 entities share several histologic features, we believe early pleomorphic hyalinizing angiectatic tumor is equivalent to hemosiderotic fibrohistiocytic lipomatous lesion/tumor and is not a true precursor to classic pleomorphic hyalinizing angiectatic tumor.
  • [MeSH-major] Blood Vessels / pathology. Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20608621.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Panzarella MJ, Naqvi AH, Cohen HE, Damron TA: Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors. Skeletal Radiol; 2005 May;34(5):272-8
Hazardous Substances Data Bank. GADOLINIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors.
  • OBJECTIVE: To determine the predictive value of gadolinium enhancement on MRI in differentiating atypical lipomatous tumor (ALT)/well-differentiated (WD) liposarcoma from benign fatty tumors.
  • Sensitivity, specificity, and positive and negative predictive values for both gadolinium enhancement and biopsy as predictors for the final diagnosis of ALT/WD liposarcoma were calculated.
  • Needle or incisional biopsy yielded 57% sensitivity, 100% specificity, 100% positive predictive value and 63% negative predictive value for a diagnosis of ALT/WD liposarcoma.
  • CONCLUSIONS: Gadolinium enhancement of a homogeneous fatty soft tissue tumor is a sensitive screening tool to determine possible diagnosis of ALT/WD liposarcoma.
  • [MeSH-major] Contrast Media. Gadolinium. Lipoma / diagnosis. Liposarcoma / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • [Cites] Skeletal Radiol. 2001 Oct;30(10):584-9 [11685482.001]
  • [Cites] Virchows Arch. 1995;427(4):353-63 [8548119.001]
  • [Cites] Acta Radiol. 1999 Jan;40(1):64-8 [9973905.001]
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  • (PMID = 15742204.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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32. Fernández-Sueiro JL, Pinto JA, Blanco FJ, Freire M, Veiga JA, Galdo F, González-Gay MA: Multiple parosteal lipoma associated to polyarthritis. Joint Bone Spine; 2006 Mar;73(2):202-4
Hazardous Substances Data Bank. PREDNISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Parosteal lipoma is a benign adipose tissue tumor situated directly in the bone cortex.
  • We describe a patient who presented with polyarthritis associated with multiple parosteal lipomatous involvement.
  • A tissue sample from the distal portion of the forearm confirmed the presence of cumulative fat tissue with nodes of esteatonecrosis.
  • [MeSH-minor] Adipose Tissue / pathology. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Drug Therapy, Combination. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prednisone / therapeutic use. Tomography, X-Ray Computed. Wrist / pathology. Wrist / radiography

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  • (PMID = 16226479.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; VB0R961HZT / Prednisone
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33. Previgliano CH, Sangster GP, Simoncini AA, Carbó AI, González E, Li B, D'Agostino H: Parosteal lipoma of the rib: a benign condition that mimics malignancy. J La State Med Soc; 2010 Jan-Feb;162(1):40-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parosteal lipoma of the rib: a benign condition that mimics malignancy.
  • They are composed of adipose tissue adjacent to the bone cortex and elicit bony reactive changes.
  • Albeit a benign condition, PL imaging findings may be misinterpreted as a malignant lesion.
  • Lipomas are benign tumors consisting of mature fat cells.
  • They are the most common mesenchymal neoplasias and account for 50% of all soft tissue tumors.
  • Musculoskeletal lipomatous lesions may be located in bones, soft tissues, and may also affect joint and tendon sheaths.
  • PL is a rare benign deep fatty-tissue tumor that arises contiguous to the periosteum without originating from it.
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 20336957.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Magro G: Mammary myofibroblastoma: a tumor with a wide morphologic spectrum. Arch Pathol Lab Med; 2008 Nov;132(11):1813-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary myofibroblastoma: a tumor with a wide morphologic spectrum.
  • CONTEXT: Myofibroblastoma (MFB) of the breast is an unusual benign tumor that belongs to the family of the "benign spindle cell tumors of the mammary stroma."
  • Since the original description, the morphologic spectrum of MFB has been expanded by the recognition of several unusual morphologic variants, such as the cellular, infiltrative, epithelioid, deciduoid-like, lipomatous, collagenized/fibrous, and myxoid variants.
  • OBJECTIVE: To review the literature on mammary MFB, discussing the main clinical, radiologic, and pathologic features helpful for diagnosis.
  • Since MFB may show alarming morphologic features, which can lead to a misdiagnosis of malignancy, histologic figures of this tumor, including its more unusual variants, are provided to offer pathologists a practical approach to a correct diagnosis.
  • Histogenesis and pathogenesis of this tumor are also proposed.
  • CONCLUSIONS: The incidence of MFB diagnosis has increased in recent years, likely due to the mammographic screening.
  • Accordingly, this unusual benign tumor may represent a potential diagnostic pitfall, especially when interpreting fine-needle aspiration and/or needle core biopsy.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasms, Muscle Tissue / pathology
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Diagnostic Errors / prevention & control. Female. Humans

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  • (PMID = 18976021.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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35. Veinot JP: Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node. Semin Diagn Pathol; 2008 Feb;25(1):29-38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node.
  • Lipomatous lesions of the heart and cystic tumor of the atrioventricular node are not common.
  • A pathologist will only rarely encounter these entities, and in the case of the atrioventricular node tumor, only if they examine the conduction system.
  • Most fatty lesions are not clinically significant; however, arrhythmias, blood flow obstruction, and valvular dysfunction may result from benign or malignant lipomatous tumors.
  • Cystic tumor of the atrioventricular node has been implicated in the causation of sudden cardiac death, and there has been much academic interest concerning its cell of origin.
  • [MeSH-major] Adipocytes / pathology. Atrioventricular Node / pathology. Heart Neoplasms / pathology. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 18350920.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Sharma G, Linden MD, Schultz DS, Inamdar KV: Cystic tumor of the atrioventricular node: an unexpected finding in an explanted heart. Cardiovasc Pathol; 2010 May-Jun;19(3):e75-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic tumor of the atrioventricular node: an unexpected finding in an explanted heart.
  • SUMMARY: We report herein a unique case of cystic tumor of atrioventricular (AV) node (CTAVN), which, to our knowledge, is the first of its kind diagnosed in an explanted heart specimen and only the fourth diagnosed antemortem.
  • Often, this rare tumor can only be diagnosed by careful gross examination and adequate sampling of AV node region.
  • It is an important differential diagnosis in young patients with syncopal attacks and varying degrees of heart blocks.
  • CONTEXT: CTAVN is a rare, benign tumor.
  • At the time of this presentation, electrocardiogram revealed second-degree AV block, and two-dimensional echocardiogram showed lipomatous hypertrophy of the interatrial septum.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19144541.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Speer AL, Schofield DE, Wang KS, Shin CE, Stein JE, Shaul DB, Mahour GH, Ford HR: Contemporary management of lipoblastoma. J Pediatr Surg; 2008 Jul;43(7):1295-300
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Lipoblastoma is a rare, benign, adipose tissue tumor.
  • [MeSH-major] Neoplasms, Adipose Tissue / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 18639685.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Dufrenot L, Pelé E, Cursolle JC, Coindre JM, Lepreux S: [Spinal epidural angiolipoma: a case report]. Ann Pathol; 2010 Feb;30(1):30-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spinal epidural angiolipoma is a rare tumor revealed by a slowly progressive paraplegia.
  • We reported a case of a 44-year-old female and point out the peculiar pattern of this lesion characterized by the prominence of the vascular component over the lipomatous component.
  • Recognition of this entity is important because this is a benign and curable cause of paraplegia.

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20223352.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Mourad OM, Andrade FM, Abrahão P, Monnerat A, Judice LF: Asymptomatic giant mediastinal mass: a rare case of thymolipoma. J Bras Pneumol; 2009 Oct;35(10):1049-52
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thymolipoma is a very rare benign neoplasm of the thymus.
  • We present the case of a 42-year-old male with a massive mediastinal tumor discovered on a chest X-ray after a motorcycle accident.
  • Chest CT scans revealed a lipomatous mass containing areas of soft tissue density.
  • The patient was submitted to median sternotomy expanded to left anterolateral thoracotomy, resulting in the complete excision of the tumor.
  • The pathological diagnosis was thymolipoma.
  • Thymolipoma usually attains enormous dimensions by the time of diagnosis, and the occasional symptoms are related to compression of adjacent structures.
  • [MeSH-major] Lipoma / diagnosis. Mediastinal Neoplasms / diagnosis. Thymus Neoplasms / diagnosis

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  • (PMID = 19918636.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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40. Parratt MT, Gokaraju K, Spiegelberg BG, Miles J, Cannon SR, Briggs TW: Myolipoma affecting the erector spinae: a case report in a child. Case Rep Med; 2009;2009:520126

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Myolipoma is a rare, benign, lipomatous tumour which most commonly occurs in the retroperitoneum, pelvis, and abdomen.
  • Magnetic Resonance Imaging (MRI) revealed a soft tissue lesion with high fat content and areas of calcification.
  • Excision and histopathological analysis revealed a tumour composed of lobules of mature adipose tissue and broad septa of well-differentiated smooth muscle tissue.
  • This paper represents the youngest patient diagnosed with this rare soft tissue tumour which is normally confined to the adult population.
  • A newly reported site of the tumour is also highlighted.

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  • (PMID = 19902012.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2774534
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41. Akhaddar A, Albouzidi A, Elmostarchid B, Gazzaz M, Boucetta M: Sudden onset of paraplegia caused by hemorrhagic spinal epidural angiolipoma. A case report. Eur Spine J; 2008 Sep;17 Suppl 2:S296-8
MedlinePlus Health Information. consumer health - Bleeding.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spinal epidural angiolipoma is a rare benign tumor containing vascular and mature adipose elements.
  • A bilateral T2-T4 laminectomy was performed to achieve resection of a lipomatous tumor containing area of spontaneous hemorrhage.
  • Histologic examination revealed the tumor as an angiolipoma.
  • Because the prognosis after rapid surgical management of this lesion is favorable, the diagnosis of spinal angiolipoma with bleeding should be considered in the differential diagnosis of hyperacute spinal cord compression.
  • [MeSH-minor] Back Pain / etiology. Decompression, Surgical. Diagnosis, Differential. Disease Progression. Epidural Space / pathology. Epidural Space / physiopathology. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Cord / pathology. Spinal Cord / physiopathology. Spine / pathology. Spine / physiopathology. Thoracic Vertebrae / pathology. Thoracic Vertebrae / physiopathology. Treatment Outcome

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  • (PMID = 18228054.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2525899
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42. Konya D, Ozgen S, Kurtkaya O, Pamir NM: Lumbar spinal angiolipoma: case report and review of the literature. Eur Spine J; 2006 Jun;15(6):1025-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spinal angiolipomas are extremely rare benign tumors composed of mature lipomatous and angiomatous elements.
  • Laminectomy was performed, and an extradural tumor was totally excised.
  • This rare clinical entity must be considered in the differential diagnosis for any spinal epidural lesion.

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  • (PMID = 16172903.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
  • [Other-IDs] NLM/ PMC3489428
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43. Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, Ranchere-Vince D, Terrier P, Pedeutour F: Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol; 2007 Oct;31(10):1476-89
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR.
  • Atypical lipomatous tumor/well-differentiated liposarcomas and dedifferentiated liposarcomas are characterized by the amplification of MDM2 and CDK4 genes.
  • To evaluate the accuracy of fluorescence in situ hybridization (FISH) analysis in the differential diagnosis of adipose tissue tumors, we investigated MDM2-CDK4 status by FISH, real-time polymerase chain reaction (PCR) [quantitative PCR (Q-PCR)] and immunohistochemistry (IHC) in a series of 200 adipose tumors.
  • First, we evaluated MDM2-CDK4 amplification and expression in a series of 94 well-defined adipose tissue tumors.
  • We then used the same techniques as complementary diagnostic tools in a series of 106 adipose and soft tissue tumors of unclear diagnosis to distinguish between (i) lipomas and atypical lipomatous tumor/well-differentiated liposarcomas, (ii) malignant undifferentiated tumors and dedifferentiated liposarcomas, and (iii) a variety of benign tumors and liposarcomas.
  • When tumor cells represented a minor component of the tumor tissue, such as with inflammatory tumors, FISH was more powerful than Q-PCR by allowing visualization of individual cells.
  • In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone.
  • [MeSH-major] Cyclin-Dependent Kinase 4 / genetics. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence / methods. Lipoma / genetics. Liposarcoma / diagnosis. Nucleic Acid Amplification Techniques. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adipose Tissue / metabolism. Adipose Tissue / pathology. Adolescent. Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Gene Expression Profiling / methods. Humans. Male. Middle Aged. Paraffin Embedding. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17895748.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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44. Donato M, Vanel D, Alberghini M, Mercuri M: Muscle fibers inside a fat tumor: a non-specific imaging finding of benignancy. Eur J Radiol; 2009 Oct;72(1):27-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Muscle fibers inside a fat tumor: a non-specific imaging finding of benignancy.
  • INTRODUCTION: The differential diagnosis between benign and low-grade well-differentiated malignant lipomatous tumors might be very difficult for both the radiologist and the pathologist, although it has practical consequences.
  • Among the criteria, muscular fibers detected inside the lesion are considered radiologically and histologically as a reliable sign of a benign intramuscular lipoma.
  • MATERIAL AND METHODS: Two cases of soft tissue fat tumors, containing muscular fibers on imaging examinations as well as histologically, had an aggressive behaviour, suggesting malignancy.
  • CONCLUSION: Intra lesional muscular fibers detected on imaging or histological examinations should not be considered as a completely reliable sign of a benign intramuscular lipoma.
  • In case of atypical clinical behaviour, genetic criteria should be used to prove the aggressiveness of the tumor.
  • [MeSH-major] Lipoma / diagnosis. Liposarcoma / diagnosis. Magnetic Resonance Imaging. Muscle Fibers, Skeletal / pathology. Muscle Neoplasms / diagnosis

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  • (PMID = 19608364.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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45. Gokhale U, Pillai GR, Varghese PV, Samarsinghe D: Chondroid lipoma: a case report. Oman Med J; 2008 Apr;23(2):116-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid lipoma is a unique, uncommon benign lipomatous tumour.
  • We report such a neoplasm with brief a review of literature.

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  • (PMID = 22379550.001).
  • [ISSN] 1999-768X
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3282416
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46. Brodsky JR, Kim DY, Jiang Z: Cervical lipoblastoma: case report, review of literature, and genetic analysis. Head Neck; 2007 Nov;29(11):1055-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Lipoblastoma is a rare, benign tumor of infants and children, usually occurring in the extremities and trunk, with only a few cases reported in the neck.
  • Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed.
  • RESULTS: Complete surgical excision via a posterior cervical approach demonstrated irregular lobules of immature fat cells separated by a loose, myxoid connective tissue.
  • Histology and genetic analysis confirmed the diagnosis of lipoblastoma.
  • MRI can be helpful in identifying the lipomatous nature of the mass, but the findings can be inconsistent due to variable maturity of fat cells and the mesenchymal content of the tumor.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 17427967.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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47. Gheri CF, Buccoliero AM, Pansini G, Castiglione F, Garbini F, Moncini D, Maccari C, Mennonna P, Pellicanò G, Ammannati F, Taddei GL: Lipoastrocytoma: Case report and review of the literature. Neuropathology; 2010 Oct;30(5):553-8
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  • Lipoastrocytoma is an extremely rare tumor, with only six cases described.
  • We report the case of an astrocytoma involving the upper part of the cerebellar-pontine angle and the right portion of the clivus starting from the brainstem with a diffuse lipomatous component in a 39 year-old man.
  • Subtotal excision of the tumor was accomplished.
  • Histologically the tumor showed the classical histology of low-grade astrocytoma and a portion of the lesion was composed of lipid-laden cells.
  • Our case has a benign postoperative behavior, also after subtotal excision, with restrictions due to the short follow-up.
  • It is important to record each new case of this rare tumor to produce a better characterization of this lesion.

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  • [Copyright] © 2010 Japanese Society of Neuropathology.
  • (PMID = 20113404.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Keywords] NOTNLM ; lipid vacuole / lipoastrocytoma / lipomatous / low grade astrocytoma
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48. Gupta P, Deo RP, Udupa KV, Ravi HR, Pai SA: A case of retropharyngeal Lipoma. Indian J Surg; 2008 Feb;70(1):40-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas are one of the most common benign mesenchymal tumors in the body.
  • Though tumor was present for 20 yrs it exhibited rapid growth over a period of 2-3 yrs causing respiratory obstruction, dysphagia & dysphonia.
  • On imaging, it showed classical features of a lipomatous mass.

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  • [Cites] Laryngoscope. 2002 Sep;112(9):1603-5 [12352671.001]
  • [Cites] Minerva Med. 2004 Jun;95(3):187-202 [15289748.001]
  • (PMID = 23133016.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452593
  • [Keywords] NOTNLM ; Lipoma / Retropharyngeal
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49. Oh JT, Choi SH, Ahn SG, Kim MJ, Yang WI, Han SJ: Vulvar lipomas in children: an analysis of 7 cases. J Pediatr Surg; 2009 Oct;44(10):1920-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Vulvar lipomas are a type of rare benign soft tissue tumor.
  • Preoperative imaging studies of ultrasound, computed tomography, and magnetic resonance imaging showed lipomatous characteristics of these tumors.
  • It is necessary to differentiate this tumor from an inguinal hernia.
  • Radiologic studies such as ultrasonography, computed tomography, and magnetic resonance imaging are useful for making the proper diagnosis.
  • [MeSH-major] Lipoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Age Factors. Child. Diagnosis, Differential. Female. Functional Laterality. Hernia, Inguinal / diagnosis. Humans. Korea / epidemiology. Magnetic Resonance Imaging / statistics & numerical data. Retrospective Studies. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Tomography, X-Ray Computed / statistics & numerical data. Treatment Outcome. Ultrasonography / statistics & numerical data

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  • (PMID = 19853747.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Kocaoğlu B, Erol B, Yalçin S, Bozkurt S, Altun E: Pediatric diffuse lipoblastomatosis of the foot -- a case report and review of the literature. Eur J Pediatr Surg; 2006 Jun;16(3):217-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diffuse lipoblastomatosis is a rare lipomatous tumor of infancy that derives from fetal-embryonal fat.
  • In spite of its benign nature, the tumor may behave in a locally aggressive manner and invade the surrounding tissues.
  • The clinical and radiological presentation and histologic evaluation of diffuse lipoblastomatosis are discussed, in order to make a differential diagnosis between this rare tumor and other soft tissue tumors.
  • In addition, the treatment principles of the tumor are described.
  • [MeSH-major] Foot Diseases / diagnosis. Lipoma / diagnosis

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  • (PMID = 16909365.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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51. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.
  • With the aim of both diagnosis and treatment, the lipomatous mass was removed by local resection.
  • In addition to the patient's age, histologic and cytogenetic analyses assisted the diagnosis of diffuse lipoblastoma.
  • [MeSH-major] Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Brandal P, Bjerkehagen B, Heim S: Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol; 2006 Feb;208(3):388-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology.
  • Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have different more or less specific chromosomal abnormalities.
  • One such entity is lipoblastoma, which is a benign lipomatous tumour that often exhibits rearrangements of chromosome bands 8q11-13, and the gene PLAG1 has been implicated as the target of these chromosomal changes.
  • All lipomatous tumours karyotyped at the Norwegian Radium Hospital were reviewed, looking for rearrangements of 8q11-13.
  • The findings raise the question as to what extent the diagnosis lipoblastoma should be based on histopathological or cytogenetic/molecular data or a combination thereof.
  • When karyotypic information from this series was combined with available literature data, it was found that the sensitivity of 8q11-13 rearrangements for diagnosing lipoblastomas when found in a lipomatous tumour was 77% and that the corresponding specificity was 98%.
  • The validity of these calculations of the diagnostic information provided by the cytogenetic findings is, of course, totally dependent on the morphological diagnosis made in each case.
  • Regardless of what the precise phenotypic diagnosis was, it is suggested that lipomatous tumours with 8q11-13 rearrangement constitute a distinct pathogenetic entity.
  • When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8. Gene Rearrangement. Lipoma / genetics. Neoplasms, Adipose Tissue / genetics

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  • (PMID = 16308870.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / PLAG1 protein, human
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53. Ogilvie CM, Torbert JT, Hosalkar HS, Stopyra GA, Lackman RD: Recurrence and bleeding in hibernomas. Clin Orthop Relat Res; 2005 Sep;438:137-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hibernomas are rare, benign, soft tissue tumors of brown fat.
  • Despite being benign, we have experienced recurrent hibernomas and cases of significant bleeding at our institution.
  • We sought to confirm that the MRI features of hibernomas could distinguish them from lipomas yet place them among lipomatous tumors.
  • An MRI was available on only one patient and showed a fatty tumor that was distinguishable from a lipoma.
  • [MeSH-major] Blood Loss, Surgical. Lipoma / pathology. Neoplasm Recurrence, Local. Soft Tissue Neoplasms / pathology. Surgical Procedures, Operative / methods

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  • (PMID = 16131882.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Svec A, Velenská Z: Renal epithelioid angiomyolipoma--a close mimic of renal cell carcinoma. Report of a case and review of the literature. Pathol Res Pract; 2005;200(11-12):851-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The epithelioid variant of angiomyolipoma (EAML) is a rare tumor of unpredictable behavior that is composed of epithelioid, spindle, and giant cells and contains no or only a minimal amount of lipomatous tissue.
  • The picture can lead to an erroneous diagnosis of renal cell carcinoma or sarcoma.
  • Grossly, a well-demarcated, spheroid, largely hemorrhagic tumor measuring 4.2 cm in diameter occupied the central third of the kidney.
  • After extensive sampling, adult-appearing fat tissue was found to present as rare foci of microscopic dimensions.
  • Immunohistochemically, the tumor cells showed positive reactions with antibodies against HMB-45, melan A, CD-68, muscle-specific actin, and, rarely, smooth muscle actin.
  • The EAML is a variant growing in a carcinoma-like pattern that can lead to an erroneous diagnosis of renal cell carcinoma.
  • An extensive sampling and HMB-45 and CD-68 positivity combined with cytokeratin negativity are of paramount importance for the correct diagnosis.
  • As a sporadic renal tumor it followed a benign course in most of the reported cases.
  • [MeSH-major] Angiomyolipoma / pathology. Carcinoma, Renal Cell / diagnosis. Epithelioid Cells / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Antigens, Neoplasm. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Giant Cells / pathology. Humans. MART-1 Antigen. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Treatment Outcome

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  • (PMID = 15792132.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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55. Chen E, Fletcher CD: Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. Am J Surg Pathol; 2010 May;34(5):707-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular angiofibroma is a mesenchymal neoplasm that is characterized by a bland spindle cell component, morphologically reminiscent of spindle cell lipoma, and thick-walled vessels.
  • The tumor occurs equally in men and women and usually arises in the inguino-scrotal or vulvovaginal regions.
  • An earlier study of 51 cases from our group showed that the tumor follows a benign course without any tendency for recurrence.
  • Tumor size ranged from 1.2 to 7.5 cm.
  • Most tumors were located in subcutaneous tissue.
  • Three of these 9 cases showed discrete nodule(s) closely resembling atypical lipomatous tumor within usual cellular angiofibroma.
  • The 3 cases with atypical lipomatous tumor-like areas were negative for MDM-2 and CDK4.
  • One patient died of metastatic carcinoma of unknown primary site 27 months after the diagnosis of cellular angiofibroma with sarcomatous transformation.
  • Cellular angiofibroma with atypia or morphologic sarcomatous transformation occurs predominantly in the subcutaneous tissue of the vulva and, as yet, shows no evident tendency to recur based on limited clinical follow-up available for 7 cases.
  • The sarcomatous component can show variable features including atypical lipomatous tumor, pleomorphic liposarcoma, and pleomorphic sarcoma NOS.
  • [MeSH-major] Angiofibroma / pathology. Cell Transformation, Neoplastic. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Vulva / pathology. Vulvar Neoplasms / chemistry. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery

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  • (PMID = 20305534.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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56. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Therefore, an accurate preoperative diagnosis is very important for proper treatment.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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57. Gelabert-González M, García-Allut A: Spinal extradural angiolipoma: report of two cases and review of the literature. Eur Spine J; 2009 Mar;18(3):324-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spinal angiolipomas are benign uncommon neoplasm composed of mature lipocytes admixed with abnormal blood vessels.
  • Prior to diagnosis 40.6% of the patients had weakness of the lower limbs.
  • The interval between the initial symptoms and tumor diagnosis ranged from 1 day to 17 years (mean 20.2 months).
  • Spinal angiolipomas are tumors containing angiomatous and lipomatous tissue, predominantly located in the mid-thoracic region.

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  • (PMID = 19127373.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 99
  • [Other-IDs] NLM/ PMC2899409
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58. Yue Q, Isobe T, Shibata Y, Anno I, Kawamura H, Yamamoto Y, Takano S, Matsumura A: New observations concerning the interpretation of magnetic resonance spectroscopy of meningioma. Eur Radiol; 2008 Dec;18(12):2901-11
Hazardous Substances Data Bank. CHOLINE CHLORIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The cases of 31 meningioma patients (27 benign and 4 nonbenign meningiomas) that underwent single-voxel 1H-MRS (PRESS sequence, TR/TE = 2,000 ms/68, 136, 272 ms) were retrospectively analyzed.
  • All meningiomas demonstrated increased choline and decreased creatine, except for a lipomatous meningioma that only displayed a prominent lipid (Lip) peak.
  • Lip not only represented micronecrosis in nonbenign meningiomas, but also reflected microcystic changes or fatty degeneration in benign meningiomas.
  • [MeSH-major] Biomarkers, Tumor / analysis. Choline / analysis. Creatine / analysis. Magnetic Resonance Spectroscopy / methods. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / metabolism. Meningioma / diagnosis. Meningioma / metabolism

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  • (PMID = 18641997.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons; MU72812GK0 / Creatine; N91BDP6H0X / Choline
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59. Patel VG, Babalola OA, Fortson JK, Weaver WL: Adrenal myelolipoma: report of a case and review of the literature. Am Surg; 2006 Jul;72(7):649-54
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adrenal myelolipoma is a rare benign tumor composed of mature lipomatous and hemopoietic tissue.
  • Although it is often discovered as an incidental finding on imaging of the abdomen for some other reason or at autopsy, adrenal myelolipoma has been reported to present with symptoms such as flank pain resulting from tumor bulk, necrosis, or spontaneous retroperitoneal hemorrhage.
  • We also review the literature to evaluate the presentation and optimal management of this rare adrenal tumor that is not encountered by most general surgeons and therefore not well known to most surgeons.

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  • (PMID = 16875091.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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60. Miller DV, Tazelaar HD: Cardiovascular pseudoneoplasms. Arch Pathol Lab Med; 2010 Mar;134(3):362-8
MedlinePlus Health Information. consumer health - Heart Diseases.

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  • CONTEXT: Primary cardiac tumors are rare and the great majority are benign neoplasms.
  • OBJECTIVE: The general clinical, imaging, gross pathologic, and histologic features of 5 important pseudoneoplasms (inflammatory myofibroblastic tumor, hamartoma of mature cardiac myocytes, mesothelial/monocytic cardiac excrescences, calcified amorphous tumor, and lipomatous hypertrophy of the atrial septum) are discussed, with an emphasis on features differentiating them from other benign and malignant tumors.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Arch Pathol Lab Med. 2010 Nov;134(11):1584-6 [21043810.001]
  • (PMID = 20196664.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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61. Buccoliero AM, Caldarella A, Bacci S, Gallina P, Taddei A, Di Lorenzo N, Romagnoli P, Taddei GL: Cerebellar liponeurocytoma: morphological, immunohistochemical, and ultrastructural study of a relapsed case. Neuropathology; 2005 Mar;25(1):77-83
Genetic Alliance. consumer health - Cerebellar Liponeurocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cerebellar liponeurocytoma is a rare and newly identified neoplasm found in adults which is reputed to be benign.
  • Its salient morphological characteristics are advanced neuronal/neurocytic differentiation, the presence of lipomatous areas, low mitotic rate, and the absence of necrosis, pleomorphism and vascular hyperplasia.
  • Histopathological aggressive features (mitoses and a high proliferation index as evaluated by MIB-1) were shown in the primary lesion and recurrence of the tumor.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 15822821.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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62. Kumazoe H, Nagamatsu Y, Nishi T, Kimura YN, Nakazono T, Kudo S: Dumbbell-shaped thoracic hibernoma: computed tomography and magnetic resonance imaging findings. Jpn J Radiol; 2009 Jan;27(1):37-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hibernoma is an uncommon, benign soft tissue tumor that arises in brown adipose tissue.
  • We report the unique appearance of a rare thoracic wall hibernoma, which appeared as a dumbbell-shaped lipomatous tumor across an intercostal region.
  • [MeSH-major] Lipoma / diagnostic imaging. Soft Tissue Neoplasms / diagnostic imaging

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  • (PMID = 19373530.001).
  • [ISSN] 1867-1071
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
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63. Dutton JJ, Wright JD Jr: Intramuscular lipoma of the superior oblique muscle. Orbit; 2006 Sep;25(3):227-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a rare intramuscular infiltrating lipomatous tumor affecting the superior oblique muscle.
  • Biopsy showed an infiltrative tumor consisting of adipocytes with included degenerated muscle fibers.
  • Histologic features were consistent with a benign intramuscular lipoma, rather than the more aggressive well-differentiated liposarcoma.
  • Enlargement of an extraocular or periorbital muscle with a low-density infiltrating lesion should raise suspicion for this unusual tumor.

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  • (PMID = 16987771.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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64. Hameed M: Pathology and genetics of adipocytic tumors. Cytogenet Genome Res; 2007;118(2-4):138-47
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The current WHO classification includes eleven benign subtypes, one intermediate and five categories of malignant fatty neoplasms with incorporation of relevant genetic findings.
  • Of the benign tumors, lipomas have been extensively analyzed by chromosome banding which has shown that their cytogenetic patterns are heterogeneous.
  • The tumor in the intermediate group, atypical lipomatous neoplasm/well-differentiated liposarcoma which poses morphologic challenges due to close histological similarity to benign lipomas shows characteristic supernumerary rings and giant rod chromosomes due to amplification of the 12q14-->q15 region often involving the MDM2 oncogene.

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 18000364.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 76
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65. Olaleye O, Fu B, Moorthy R, Lawson C, Black M, Mitchell D: Left supraclavicular spindle cell lipoma. Int J Otolaryngol; 2010;2010:942152

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Background. Spindle cell lipoma (SCL) is a benign lipomatous tumour, typically occurring in the posterior neck, shoulder or upper back of elderly males.
  • This case highlights a rare presentation of SCL and the need for pre-operative diagnosis. Case Report.
  • Conclusion. Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management.

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  • (PMID = 20508829.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2876251
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66. Petrović J, Barisić G, Saranović D, Micev M, Krivokapić Z: Lipomatosis of the ileocecal valve treated with right hemicolectomy as the consequence of an incomplete diagnostic procedure. Tech Coloproctol; 2007 Sep;11(3):278-80
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It can occur within digestive system as a benign mass.
  • She had a lipomatous change of ileocecal valve and due to positive fecal occult blood test, barium enema and incompletely performed colonoscopy was misdiagnosed as a malignant tumor and was treated accordingly.
  • [MeSH-major] Colectomy / methods. Ileal Neoplasms / diagnosis. Ileal Neoplasms / surgery. Ileocecal Valve. Lipomatosis / diagnosis. Lipomatosis / surgery
  • [MeSH-minor] Diagnosis, Differential. Diagnostic Errors. Female. Humans. Middle Aged

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  • (PMID = 17676259.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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67. Xu Y, Wang J, Peng Y, Zeng J: CT characteristics of primary retroperitoneal neoplasms in children. Eur J Radiol; 2010 Sep;75(3):321-8
MedlinePlus Health Information. consumer health - CT Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neuroblastoma, rhabdomyosarcoma, benign teratoma and lymphoma are the common retroperitoneal neoplasms.
  • In children, lipoblastoma is the most common lipomatous tumor in the retroperitoneum.
  • The percentage of visible fat in tumor varies depending on the cellular composition of the lesion.
  • In conclusion, making a final histological diagnosis of retroperitoneal tumor base on CT features is not often possible; however, CT can help to develop a differential diagnosis and determine the size and extent of the retroperitoneal neoplasms.

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  • [Copyright] Copyright © 2010. Published by Elsevier Ireland Ltd.
  • (PMID = 20591598.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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68. Jang YW, Kim SG, Pai H, Park JW, Lee YC, Rotaru H: Sialolipoma: case report and review of 27 cases. Oral Maxillofac Surg; 2009 Jun;13(2):109-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: This article presents a patient with sialolipoma of the submandibular gland, a rare neoplasm, and reviews related literatures.
  • Unlike other lipomatous lesion in the oral cavity, definite male predilection was not observed in the sialolipoma.
  • The most common site for the tumor was the parotid gland (17 cases, 60.7%), followed by the palate (four cases, 14.2%).
  • Histopathologically, a tumor was a benign lesion with proliferating lipocytes including scattered foci with a normal salivary gland tissue.
  • CONCLUSION: Sialolipoma is a rare benign neoplasm in the head and neck and it shows equal sex predilection.
  • [MeSH-major] Lipoma / diagnosis. Submandibular Gland Neoplasms / diagnosis

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  • (PMID = 19347375.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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69. Rekhi B, Gorad BD, Kakade AC, Chinoy R: Scope of FNAC in the diagnosis of soft tissue tumors--a study from a tertiary cancer referral center in India. Cytojournal; 2007;4:20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Scope of FNAC in the diagnosis of soft tissue tumors--a study from a tertiary cancer referral center in India.
  • Its role in diagnosing soft tissue tumors (STT) has been fairly documented, as well as debated.
  • Present study was aimed at evaluating its scope in diagnosing 127 cases of soft tissue tumors.
  • RESULTS: 50% cases were referred for a primary diagnosis, while 26.8% & 22.8% cases were evaluated for recurrent and metastatic lesions, respectively.
  • On FNAC, 101 cases (79.5%) were labeled as malignant, whereas 10 cases (7.9%) were labeled as benign.
  • Histopathological confirmation in 115 cases, gave a diagnostic accuracy of 98%, with a positive predictive value of 98% in malignant cases and a negative predictive value of 100% in benign cases.
  • Among the various cytological categories, 60 cases (47.2%) were of spindle cell type, followed by 32 (25.2%) of round cell type and 14 cases (11%) of lipomatous type.
  • Exact cytological sub typing was offered in 58 cases, with rhabdomyosarcoma (RMS) as the most frequently sub typed tumor.

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  • (PMID = 17973999.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2164954
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70. Casanova Espinosa A, Cisneros Serrano C, Girón Moreno RM, Olivera MJ, Moreno Balsalobre R, Zamora García E: [Pleural empyema associated with endobronchial lipoma]. Arch Bronconeumol; 2005 Mar;41(3):172-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Bronchial benign tumors comprise fewer than 4% of pulmonary neoplasms.
  • Endobronchial lipoma is an extremely rare benign neoplasm accounting for only 0.1% to 0.5% of all lung tumors.
  • Clinical symptoms of lipoma depend on the location of the tumor, the severity of bronchial obstruction, and the functional and anatomical effects on the parenchyma distal to the obstruction.
  • Computed axial tomography usually reveals the adipose composition of the lipomatous tumor.
  • We report the case of an 83-year-old man diagnosed with community-acquired pneumonia that led to complications: pleural empyema caused by Haemophilus influenzae infection and atelectasis of the right middle and lower lobes secondary to a lipomatous endobronchial obstruction.

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  • (PMID = 15766470.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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71. Koplin SA, Twohig MH, Lund DP, Hafez GR: Omental lipoblastoma. Pathol Res Pract; 2008;204(4):277-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This unusual tumor is only the eighth reported omental lipoblastoma [J. Hicks, A. Dilley, D. Patel, J.
  • Goldblum, Enzinger and Weiss's Soft Tissue Tumors, fourth ed., Mosby, St. Louis, MO, 2001, pp.
  • Lakhoo, Omental lipoblastoma in a child; diagnosis based in CT density measurements. J. Pediatr. Hematol. Oncol.
  • Alvarenga, Sonographic features of benign intraperitoneal lipomatous tumors in children-report of 4 cases. Pediatr. Radiol.
  • [MeSH-major] Neoplasms, Adipose Tissue / pathology. Omentum / pathology. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Chromosomes, Human, Pair 14. Chromosomes, Human, Pair 8. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Infant. Karyotyping. Liposarcoma, Myxoid / pathology. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18276084.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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72. Yoshida A, Ushiku T, Motoi T, Shibata T, Fukayama M, Tsuda H: Well-differentiated liposarcoma with low-grade osteosarcomatous component: an underrecognized variant. Am J Surg Pathol; 2010 Sep;34(9):1361-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We herein describe 9 cases of well-differentiated/dedifferentiated liposarcoma with distinct areas of fibroosseous tissue histologically indistinguishable from low-grade osteosarcomas, that is, parosteal osteosarcoma or low-grade central osteosarcoma.
  • The tumors affected middle-aged to elderly patients, and occurred in the retroperitoneum and deep soft tissue of the extremities without connection to the skeletal system.
  • Grossly, all the tumors showed biphasic appearance with lipogenic and osteogenic area, the latter representing 5% to 50% of the total tumor volume.
  • Histologically, the lipogenic component exhibited typical histology of well-differentiated liposarcoma, whereas the osteogenic area consisted of fibroosseous tissue with numerous mature neoplastic bone trabeculae largely lacking osteoblastic rimming, with intervening fascicles of spindle cell proliferation showing low nuclear grade.
  • Recognition of this earlier underappreciated subtype of well-differentiated/dedifferentiated liposarcoma is important, because the fibroosseous component may seem so bland that it may be confused with benign metaplasia such as myositis ossificans, or conversely, the lipomatous component may be inconspicuous that it may be dismissed as normal fat, and such misinterpretation may potentially result in suboptimal treatment.
  • [MeSH-major] Bone Neoplasms / pathology. Liposarcoma / pathology. Neoplasms, Multiple Primary. Osteosarcoma / pathology. Retroperitoneal Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase 4 / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Proto-Oncogene Proteins c-mdm2 / metabolism. Tomography, X-Ray Computed

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  • (PMID = 20697254.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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73. Agabiti S, Gurrera A, Amico P, Vasquez E, Magro G: [Mammary hamartoma with atypical stromal cells: a potential diagnostic dilemma]. Pathologica; 2007 Dec;99(6):434-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although atypical stromal cell (ASCs) can be encountered in several benign and malignant breast lesions, their occurrence in hamartoma has not been reported to date.
  • This unusual feature raised differential diagnostic problems with pleomorphic lipoma, well-differentiated liposarcoma and malignant phylloid tumour with a lipomatous heterologous component.
  • [MeSH-major] Breast Diseases / diagnosis. Hamartoma / diagnosis
  • [MeSH-minor] Antigens, CD34 / analysis. Biomarkers. Breast Neoplasms / diagnosis. Diagnosis, Differential. Female. Fibroblasts / chemistry. Fibroblasts / pathology. Humans. Lipoma / diagnosis. Liposarcoma / diagnosis. Middle Aged. Phyllodes Tumor / diagnosis. Stromal Cells / chemistry. Stromal Cells / pathology. Vimentin / analysis

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  • (PMID = 18416336.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Vimentin
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74. Binh MB, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagacé R, Aurias A, Hostein I, Coindre JM: MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol; 2005 Oct;29(10):1340-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data.
  • Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively.
  • We examined a series of 559 soft tissue tumors (44 ALT-WDLPS, 61 DDLPS, 49 benign adipose tumors, and 405 non-ALT-WDLPS/DDLPS sarcomas) for MDM2 and CDK4 expression using immunohistochemistry.
  • Most ALT-WDLPS/DDLPS expressed MDM2 (97%) and CDK4 (92%) as opposed to few benign adipose tumors (MDM2, 5%; CDK4, 2%) and a limited number of non-ALT-WDLSP/DDLPS sarcomas (MDM2, 19%; CDK4, 6%).
  • The sensitivity and specificity of MDM2 and CDK4 immunostainings in identifying ALT-WDLPS/DDLPS among other soft tissue tumors were 97% and 92%, and 83% and 95%, respectively.
  • MDM2 and CDK4 immunostainings were particularly useful to separate ALT-WDLPS from the large group of differentiated adipose tumors, and to distinguish DDLPS from poorly differentiated sarcomas.
  • In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.
  • [MeSH-major] Cyclin-Dependent Kinase 4 / metabolism. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Gene Amplification. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 16160477.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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75. Shah JR, Patkar D, Gala BM: Multiple intramedullary lipomas with conal intramedullary dermoid: magnetic resonance appearances. Spine J; 2007 May-Jun;7(3):368-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND CONTEXT: Intramedullary fat-containing benign childhood tumors of the cord include lipomas, dermoid cysts, and teratomas.
  • Multiple intramedullary lipomas are rare and may represent a spinal lipomatous malformation.
  • The presence of another intramedullary dermoid tumor in the same case is rare.
  • CONCLUSION: Multiple intramedullary lipomas with an intramedullary dermoid represent a form of spinal lipomatous malformation.
  • [MeSH-major] Lipoma / diagnosis. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 17482123.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Bord A, Valsky DV, Yagel S: Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature. Prenat Diagn; 2006 Nov;26(11):1065-7
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for skin tag .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature.
  • BACKGROUND: Skin tags, or acrochordons, are benign, soft, fleshy tumors that are composed of hyperplastic epidermis covering a dermal connective tissue stalk.
  • METHODS: Case report of a congenital perineal skin tag that presented as a perineal tumor during second-trimester sonographic scan at 23 weeks' gestation.
  • The lesion was removed; pathologic examination revealed a lipomatous skin tag.

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  • (PMID = 16952203.001).
  • [ISSN] 0197-3851
  • [Journal-full-title] Prenatal diagnosis
  • [ISO-abbreviation] Prenat. Diagn.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 6
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77. Allon I, Vered M, Dayan D: Liposarcoma of the tongue: clinico-pathologic correlations of a possible underdiagnosed entity. Oral Oncol; 2005 Aug;41(7):657-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • LS of the tongue is a tumor of adult and old age, with a mean age of approximately 62 years and a peak incidence in the seventh and eighth decades.
  • Clinically, it is a long-standing tumor that commonly presents as a solitary nodular mass, but can also present as a multi-nodular lesion.
  • The most common histopathologic type is that of atypical lipomatous tumor (ALT)/well-differentiated LS (75%).
  • LS can be easily misdiagnosed with both benign and malignant lipomatous and non-lipomatous tumors.
  • When a lipomatous lesion is encountered in the oral cavity, and especially in the tongue, LS should certainly be among the lesions that top the list of differential diagnosis.
  • The follow-up must be on a long-term basis since this tumor can recur years after initial surgical treatment and can also undergo dedifferentiation.

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  • (PMID = 16023982.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 27
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78. Buurman H, Saeger W: Abnormalities in incidentally removed adrenal glands. Endocr Pathol; 2006;17(3):277-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Other indications for adrenalectomies were malignant tumors (urothelial carcinoma, squamous cell carcinoma, sarcoma, lymphoma, etc.) and benign findings (oncocytoma, angiomyolipoma, pyelonephritis, etc.).
  • A total of 18 adrenals exhibited a metastasis or diffuse infiltration of the adrenal or para-adrenal tissue by a malignant tumor (17 renal cell carcinomas, 1 non-Hodgkin's lymphoma).
  • Eighty-six adrenals included myelolipomatous or lipomatous foci.

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  • (PMID = 17308364.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM: Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol; 2009 Dec;62(12):1127-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours.
  • METHODS: IHC for MDM2/CDK4 was carried out on a series of 129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours.
  • The cases were divided into four groups: WDLPS (n = 19), DDLPS (n = 10), benign adipocytic tumours (BAT) (n = 17), and other mesenquimal tumours (OMT) (n = 83).
  • IHC results were compared in each group and the diagnostic efficacy of the test in identifying WDLPS and DDLPS among the other soft tissue tumours was determined.
  • A percentage of tumour cell positivity was evaluated to better characterise the pattern of tumour immunostaining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase 4 / metabolism. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Sensitivity and Specificity

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  • (PMID = 19946100.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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80. de Moraes M, de Matos FR, de Carvalho CP, de Medeiros AM, de Souza LB: Sialolipoma in minor salivary gland: case report and review of the literature. Head Neck Pathol; 2010 Sep;4(3):249-52
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sialolipoma is a rare benign neoplasm characterized by a well-circumscribed mass composed of neoplastic mature adipose tissue and non-neoplastic salivary gland elements.
  • Microscopically, the tumor was well-circumscribed consisting of lobular proliferation of the lipomatous tissue with thin fibrous tissue septa containing clustered salivary gland elements.
  • Both the glandular and adipose components were found in almost equal proportion.
  • No atypia in the adipose tissue was observed.
  • The definitive diagnosis was sialolipoma.
  • The age distribution was from 27 to 84 years (mean, 61.6 years) and the tumor size ranged from 0.9 to 4 cm (mean, 1.7 cm).

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  • (PMID = 20563675.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923305
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81. Agaimy A, Märkl B, Kitz J, Wünsch PH, Arnholdt H, Füzesi L, Hartmann A, Chetty R: Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants. Virchows Arch; 2010 Apr;456(4):411-22
Genetic Alliance. consumer health - Schwannoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Unusual histological variants included sigmoid GCT with prominent lipomatous component (n = 1), reticular-microcystic schwannoma of small (n = 1) and large (n = 1) bowel, NF1-associated gastric schwannoma (the first case to date), and psammomatous melanotic colonic schwannoma unrelated to Carney complex (n = 1).
  • In conclusion, PNSTs of the GI tract are rare uniformly benign neoplasms that may show schwannian, perineurial, fibroblastic, or mixed differentiation.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Granular Cell Tumor / diagnosis. Granular Cell Tumor / epidemiology. Granular Cell Tumor / pathology. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Young Adult

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  • (PMID = 20155280.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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82. Shilo K, Miettinen M, Travis WD, Timens W, Nogueira R, Franks TJ: Pulmonary microcystic fibromyxoma: Report of 3 cases. Am J Surg Pathol; 2006 Nov;30(11):1432-5
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Innocuous, widely-spaced, spindled to stellate tumor cells showed minimal nuclear pleomorphism and absence of mitotic activity.
  • No epithelial, chondroid, neural, myofibroblastic, lipomatous or vascular differentiation was evident on immunohistochemical studies.
  • Although these cases display cytologic features, myxoid stroma and benign clinical course characteristic of pulmonary myxomas; the presence of microcystic architecture is unique to the current series, and thus a descriptive designation "microcystic fibromyxoma" is suggested.

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  • (PMID = 17063085.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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