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1. Inaba H, Suzuki S, Shigematsu S, Shinomiya K, Ohfusa H, Shimojo Y, Uehara T, Hashizume K: Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency. Intern Med; 2009;48(8):601-5
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  • [Title] Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency.
  • Five years earlier, he underwent simultaneous surgeries for an adrenal adenoma, a benign Leydig cell tumor (LCT), and a malignant lymphoma.
  • On immunohistochemistry analysis using the antibody against adrenal-specific 11beta-hydroxylase antibody, the LCT showed both properties as a testicular cell and as an adrenal cell.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / complications. Adrenal Hyperplasia, Congenital / diagnosis. Leydig Cell Tumor / etiology. Lymphoma / etiology. Testicular Neoplasms / etiology
  • [MeSH-minor] Adrenal Gland Neoplasms / etiology. Adrenal Gland Neoplasms / surgery. Adrenocortical Adenoma / etiology. Adrenocortical Adenoma / surgery. Humans. Hypoglycemia / diagnosis. Hypoglycemia / etiology. Male. Middle Aged

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  • (PMID = 19367056.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Shiraishi Y, Nishiyama H, Okubo K, Iguchi R, Inoue T, Watanabe J, Kamba T, Yoshimura K, Kanematsu A, Nakayama T, Hatayama H, Ogawa O: [Testicular Leydig cell tumor presenting as male infertility: a case report]. Hinyokika Kiyo; 2009 Dec;55(12):777-81
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  • [Title] [Testicular Leydig cell tumor presenting as male infertility: a case report].
  • A Leydig cell tumor is a rare disease entity occurring in the testis.
  • We report a case study of a Leydig cell tumor in a single testis presenting as male infertility.
  • A 38-year-old male was referred to our hospital because of a tumor in his right testis.
  • He had undergone left orchiectomy at one year old because of a testicular tumor.
  • During an examination related to the infertility, ultrasound revealed a 1 cm tumor.
  • Tumor markers were all within normal ranges.Hormonal examination showed that luteinizing hormone (LH) 30.3 mIU/ml (1.5-12.4) and follicle stimulating hormone (FSH) 11.9 mIU/ml (1.7-8.6) were higher than normal limits, but total testosterone(total T) and estradiol (E2) were within normal ranges.
  • Tumor enucleation was first performed, and then testicular sperm extraction (TESE) was carried out from a macroscopically normal site of the testis.Histopathological diagnosis was a benign Leydig cell tumor surrounded by Leydig cell hyperplasia.
  • [MeSH-major] Infertility, Male / etiology. Leydig Cell Tumor / complications. Testicular Neoplasms / complications

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  • (PMID = 20048565.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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3. Agrawal U, Sharma M, Bhatnagar D, Saxena S: Leydig cell tumor: an unusual presentation. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):395-6
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  • [Title] Leydig cell tumor: an unusual presentation.
  • Leydig cell tumor is a benign tumor of the testis and malignant transformation, if present, is rare.
  • The case could not be labeled as benign or malignant and patient is on follow-up.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Leydig Cell Tumor / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology

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  • (PMID = 19679972.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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4. Giannarini G, Mogorovich A, Menchini Fabris F, Morelli G, De Maria M, Manassero F, Loggini B, Pingitore R, Cavazzana A, Selli C: Long-term followup after elective testis sparing surgery for Leydig cell tumors: a single center experience. J Urol; 2007 Sep;178(3 Pt 1):872-6; quiz 1129
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  • [Title] Long-term followup after elective testis sparing surgery for Leydig cell tumors: a single center experience.
  • PURPOSE: Although most Leydig cell tumors are benign, radical orchiectomy is currently considered the standard therapy.
  • We retrospectively analyzed the long-term followup of a series of patients with Leydig cell tumors electively treated with testis sparing surgery.
  • MATERIALS AND METHODS: Between November 1990 and December 2005, 17 consecutive patients with Leydig cell tumors underwent testis sparing surgery on an elective basis.
  • Preoperative evaluation included physical examination, serum markers for germ cell tumors, scrotal ultrasound, abdominal computerized tomography, chest x-ray and hormonal profile if clinically required.
  • Frozen section examination was performed in all cases, revealing Leydig cell tumors.
  • Tumor recurrence and survival were evaluated.
  • Mean tumor diameter was 13.4 mm (range 5 to 31).
  • Definitive pathological examination confirmed benign Leydig cell tumor in all cases.
  • CONCLUSIONS: In patients with Leydig cell tumors testis sparing surgery with frozen section examination provides an excellent long-term oncological outcome.
  • [MeSH-major] Leydig Cell Tumor / surgery. Testicular Neoplasms / surgery

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  • (PMID = 17631320.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Connolly SS, D'Arcy FT, Bredin HC, Callaghan J, Corcoran MO: Value of frozen section analysis with suspected testicular malignancy. Urology; 2006 Jan;67(1):162-5
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  • OBJECTIVES: To determine whether frozen section analysis (FSA) assists safe conservative surgery for men presenting with suspected testicular tumors.
  • The exclusion criteria included lesions of paratesticular origin, size greater than 5 cm, and the known presence of elevated tumor markers or metastatic disease.
  • RESULTS: Eighty men underwent FSA, facilitating the diagnosis of germ cell malignancy in 51 (54.3%) of the 94 new cases encountered during this period.
  • Malignancy was reported by FSA in 52 patients (65.0%), but was later revised in 3 to benign Leydig cell tumor after orchiectomy.
  • Also, 2 of 27 specimens reported as benign by FSA were revised to malignant after analysis of paraffin-embedded tissue from the biopsies.
  • FSA was reported as "suspicious" (intratubular germ cell neoplasia with necrosis) in 1 patient, in whom orchiectomy was performed and malignancy confirmed.
  • Of 13 lesions 1 cm or less, 10 (76.9%) were benign.

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  • (PMID = 16413354.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Basciani S, Brama M, Mariani S, De Luca G, Arizzi M, Vesci L, Pisano C, Dolci S, Spera G, Gnessi L: Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity. Cancer Res; 2005 Mar 1;65(5):1897-903
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  • [Title] Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity.
  • Leydig cell tumors are usually benign tumors of the male gonad.
  • However, if the tumor is malignant, no effective treatments are currently available.
  • Leydig cell tumors express platelet-derived growth factor (PDGF), kit ligand and their respective receptors, PDGFR and c-kit.
  • We therefore evaluated the effects of imatinib mesylate (imatinib), a selective inhibitor of the c-kit and PDGFR tyrosine kinases, on the growth of rodent Leydig tumor cell lines in vivo and in vitro, and examined, in human Leydig cell tumor samples, the expression of activated PDGFR and c-kit and the mutations in exons of the c-kit gene commonly associated with solid tumors.
  • Imatinib caused concentration-dependent decreases in the viability of Leydig tumor cell lines, which coincided with apoptosis and inhibition of proliferation and ligand-stimulated phosphorylation of c-kit and PDGFRs.
  • Mice bearing s.c. allografts of a Leydig tumor cell line treated with imatinib p.o., had an almost complete inhibition of tumor growth, less tumor cell proliferation, increased apoptosis, and a lesser amount of tumor-associated mean vessel density compared with controls.
  • No drug-resistant tumors appeared during imatinib treatment but tumors regrew after drug withdrawal.
  • Human Leydig cell tumors showed an intense expression of the phosphorylated form of c-kit and a less intense expression of phosphorylated PDGFRs.
  • Our studies suggest that Leydig cell tumors might be a potential target for imatinib therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Apoptosis / drug effects. Leydig Cell Tumor / prevention & control. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Animals. Benzamides. Cell Proliferation / drug effects. Humans. Imatinib Mesylate. In Vitro Techniques. Ligands. Male. Mice. Mice, Inbred C57BL. Mutation / genetics. Phosphorylation / drug effects. Platelet-Derived Growth Factor / genetics. Platelet-Derived Growth Factor / metabolism. Protein-Tyrosine Kinases / antagonists & inhibitors. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism. Proto-Oncogene Proteins c-sis / genetics. Proto-Oncogene Proteins c-sis / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Rats. Rats, Sprague-Dawley. Receptor, Platelet-Derived Growth Factor alpha / genetics. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Receptor, Platelet-Derived Growth Factor beta / genetics. Receptor, Platelet-Derived Growth Factor beta / metabolism

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  • (PMID = 15753388.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Ligands; 0 / Piperazines; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / Pyrimidines; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / platelet-derived growth factor A; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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7. Marcelino M, Nobre E, Conceição J, Lopes L, Vilar H, França Martins M, Carvalho A, André S, Horta A, De Castro JJ: [A rare case of hyperandrogenism: bilateral Leydig cell tumor of the ovary]. Acta Med Port; 2010 Jan-Feb;23(1):113-8
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  • [Title] [A rare case of hyperandrogenism: bilateral Leydig cell tumor of the ovary].
  • [Transliterated title] Um caso raro de hiperandrogenismo tumor ovárico bilateral de células de Leydig.
  • BACKGROUND: The androgen-secreting tumors constitute fewer than 1% of ovarian tumors.
  • Leydig cell tumor is one of the most common of this type of lesion and it is usually benign, small and unilateral.
  • Transvaginal ultrasonography and abdomen-pelvic CT scan didn't show any signs of adrenal or ovarian tumors.
  • Bilateral oophorectomy was performed and histopathologic exam revealed bilateral Leydig cell tumors, measuring 1cm each.
  • DISCUSSION: Androgen-secreting tumors are rare, but they should be excluded in cases of rapid onset of virilization and elevated androgen levels.
  • Tumors are frequently undetectable by imaging techniques because of their small dimensions, exploratory surgery by a skilled team is frequently necessary and is often the best treatment for the majority of these cases.
  • In this case report we present a rare case of bilateral Leydig cell tumor.
  • Only five cases have been reported in the literature.The clinical history and the elevated levels of testosterone had suggested the presence of an androgen-producing tumor, despite the difficulty of the diagnosis on imaging techniques.
  • [MeSH-major] Hirsutism / etiology. Leydig Cell Tumor / complications. Ovarian Neoplasms / complications

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  • (PMID = 20353714.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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8. Heer R, Jackson MJ, El-Sherif A, Thomas DJ: Twenty-nine Leydig cell tumors: histological features, outcomes and implications for management. Int J Urol; 2010 Oct;17(10):886-9
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  • [Title] Twenty-nine Leydig cell tumors: histological features, outcomes and implications for management.
  • Leydig cell tumors are the most common interstitial neoplasm of the testes.
  • Between June 1998 and March 2009, 29 patients underwent surgery for Leydig cell tumor of the testis in our cancer network.
  • Our data suggest that, in the absence of high-risk histopathological features, this tumor can be safely regarded as benign, pending a longer-term follow-up evaluation.
  • [MeSH-major] Leydig Cell Tumor / pathology. Leydig Cell Tumor / surgery. Testicular Neoplasms / pathology. Testicular Neoplasms / surgery

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  • (PMID = 20812939.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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9. Carmignani L, Colombo R, Gadda F, Galasso G, Lania A, Palou J, Algaba F, Villavicencio H, Colpi GM, Decobelli O, Salvioni R, Pizzocaro G, Rigatti P, Rocco F: Conservative surgical therapy for leydig cell tumor. J Urol; 2007 Aug;178(2):507-11; discussion 511
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  • [Title] Conservative surgical therapy for leydig cell tumor.
  • PURPOSE: We performed a long-term evaluation of conservative surgical treatment of benign Leydig cell tumor.
  • Case files of all patients diagnosed with Leydig cell tumor and treated with conservative surgery were examined.
  • Patients underwent physical examination, hormone and tumor marker assays, scrotal and abdominal ultrasound, chest x-ray, and an endocrinological examination.
  • RESULTS: From 1987 to 2006, 22 patients with Leydig cell tumor underwent conservative surgery.
  • Three patients were monorchid after contralateral orchiectomy for inguinal hernia repair (1 patient, 28 years before surgery) and nonseminomatous germ cell tumor (2 patients, 1 month and 6 years before surgery).
  • Diagnosis after frozen section examination was Leydig cell tumor in 20 of 22 cases (91.0%).
  • Tumor markers were normal before and after surgery.
  • Followup was conducted for all patients every 3 to 6 months with physical examination, tumor markers, scrotal and abdominal ultrasound, chest x-ray.
  • CONCLUSIONS: When diagnosed early Leydig cell tumors present a favorable followup.
  • [MeSH-major] Leydig Cell Tumor / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Diagnosis, Differential. Early Diagnosis. Humans. Male. Middle Aged. Neoplasm Staging. Orchiectomy. Retrospective Studies. Testis / pathology. Testis / surgery

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  • (PMID = 17561156.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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10. Gilbert R, Kutzler M, Valentine BA, Semevolos S: Hyperandrogenism from an ovarian interstitial-cell tumor in an alpaca. J Vet Diagn Invest; 2006 Nov;18(6):605-7
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  • [Title] Hyperandrogenism from an ovarian interstitial-cell tumor in an alpaca.
  • An ovarian benign interstitial (Leydig) cell tumor was diagnosed.
  • [MeSH-major] Camelids, New World. Hyperandrogenism / veterinary. Leydig Cell Tumor / veterinary. Ovarian Neoplasms / veterinary. Ovary / pathology. Theca Cells / secretion

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  • (PMID = 17121093.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone
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11. Zafrakas M, Venizelos ID, Theodoridis TD, Zepiridis L, Agorastos T, Bontis JN: Virilizing ovarian hilus (Leydig) cell tumor with concurrent contralateral hilus cell hyperplasia: a rare diagnosis. Eur J Gynaecol Oncol; 2009;30(3):338-40
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  • [Title] Virilizing ovarian hilus (Leydig) cell tumor with concurrent contralateral hilus cell hyperplasia: a rare diagnosis.
  • Ovarian hilus or Leydig cell tumor and ovarian hilus cell hyperplasia are rare clinical entities, causing virilization in both pre- and postmenopausal women.
  • We report herein an extremely rare case of ovarian hilus or Leydig cell tumor, presenting concurrently with contralateral ovarian hilus cell hyperplasia in a postmenopausal woman with virilization.
  • Ovarian hilus cell tumors and hilus hyperplasia almost always have benign biological behavior, thus making bilateral salpingo-oophorectomy an appropriate and sufficient therapeutic approach.
  • [MeSH-major] Leydig Cell Tumor / pathology. Ovarian Neoplasms / pathology. Virilism / etiology

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  • (PMID = 19697637.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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12. Chovelidze ShG, Kochiashvili DK, Gogeshvili GG, Getta T, Lababidi A: [Cases of Leydig cell tumor in male infertility]. Georgian Med News; 2007 Feb;(143):76-9
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  • [Title] [Cases of Leydig cell tumor in male infertility].
  • Leydig cell tumor was found in 4 patients, among them 3 by palpation and testicle echography, fourth patient (at the age of 33) with bilateral varicocele (III stage at the left, II stage at the right) was more interesting for us.
  • Leydig cell tumor was found out at the scrotum exploration.
  • The node enucleation away from tumor by 0.5 cm has been carried out.
  • Exact histological investigation confirmed the presence of Leydig cell tumor.
  • In 6 years after surgical operation the tumor node 1.8 mm in diameter has been found out in right (contra lateral) testis.
  • The patient was urgently operated, ex-tempo investigation confirmed the presence of Leydig cell tumor in right testicle--high orchidectomy at the right has been carried out.
  • Given case shows that the enucleation of Leydig cell tumor proves to be equivalent alternative of orchidectomy, which is suggested by many authors.
  • Taking into account the presence of encapsulation and tumor benignity it is important to have opportunity of the testicle preservation due to infertility problems.
  • [MeSH-major] Infertility, Male / etiology. Leydig Cell Tumor / complications. Leydig Cell Tumor / pathology. Testicular Neoplasms / complications. Testicular Neoplasms / pathology

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  • (PMID = 17404447.001).
  • [ISSN] 1512-0112
  • [Journal-full-title] Georgian medical news
  • [ISO-abbreviation] Georgian Med News
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Georgia (Republic)
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13. Rubio Tortosa I, Rodrigo Guanter V, García Torrelles M, Verges Prosper A, Planelles Gómez J, San Juan de Laorden C: [Leydig cell tumor: our experience. Bibliographic review]. Arch Esp Urol; 2006 Jun;59(5):467-72
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  • [Title] [Leydig cell tumor: our experience. Bibliographic review].
  • [Transliterated title] Tumor de células de Leydig: nuestros casos y revisión de la literatura.
  • OBJECTIVES: To report the case-series of Leydig cell tumors diagnosed at our center, and to perform a bibliographic review on the topic.
  • METHODS: Retrospective review of the clinical records of all patients with the diagnosis of Leydig cell tumor in our center over the last 12 years.
  • CONCLUSIONS: It is a rare testicular tumor.
  • [MeSH-major] Leydig Cell Tumor. Testicular Neoplasms

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  • (PMID = 16903547.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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14. Henderson CG, Ahmed AA, Sesterhenn I, Belman AB, Rushton HG: Enucleation for prepubertal leydig cell tumor. J Urol; 2006 Aug;176(2):703-5
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  • [Title] Enucleation for prepubertal leydig cell tumor.
  • PURPOSE: Leydig cell tumors in children are rare, comprising only 4% to 9% of all primary testis tumors in prepubertal males.
  • We present our experience with testis sparing enucleation of Leydig cell tumor in prepubertal boys.
  • RESULTS: Both patients had normalization of the serum testosterone following enucleation of the Leydig cell tumor.
  • CONCLUSIONS: Prepubertal boys with isosexual precocious pseudopuberty, an isolated testis mass, increased testosterone and low or normal gonadotropin levels can reliably be diagnosed with Leydig cell tumors.
  • Based on the ability to establish the diagnosis preoperatively and the universal benign behavior of unilateral, prepubertal Leydig cell tumor, we believe these patients are best treated with testis sparing enucleation of the tumor.
  • In view of the high likelihood that this tumor in prepubertal boys is benign, a transscrotal surgical approach should be considered.
  • [MeSH-major] Leydig Cell Tumor / surgery. Testicular Neoplasms / surgery

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  • (PMID = 16813923.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Al-Agha OM, Axiotis CA: An in-depth look at Leydig cell tumor of the testis. Arch Pathol Lab Med; 2007 Feb;131(2):311-7
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  • [Title] An in-depth look at Leydig cell tumor of the testis.
  • Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium.
  • The tumor is usually benign, but malignant variants can occur.
  • The pathologic diagnosis of LCT is usually made based on morphologic characteristics of the tumor cells.
  • Pathologists have to be familiar with the diagnostic histopathologic features, immunohistochemical panel of this tumor, and its principal differential diagnoses to prevent tumor misdiagnosis.
  • [MeSH-major] Leydig Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Sarcoma / pathology

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  • (PMID = 17284120.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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16. Huyghe E, Nohra J, Vezzozi D, Daudin M, Bennet A, Caron P, Thonneau P, Plante P: [Fertility before and after treatment of patients with Leydig cell tumour]. Prog Urol; 2007 Jun;17(4):841-5
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  • [Title] [Fertility before and after treatment of patients with Leydig cell tumour].
  • [Transliterated title] Fertilité avant et après traitement des patients présentant une tumeur à cellule de Leydig.
  • OBJECTIVE: To determine the long-term fertility status of patients treated for Leydig cell testicular tumour.
  • MATERIAL AND METHODS: [corrected] In a series of 506 testicular tumours observed in the Midi-Pyrenées region between 1980 and 1998, 17 were Leydig cell tumours (3.3%) and constituted the study population.
  • After treatment of their Leydig cell tumour, 10/17 (58.8%) had tried to have a child and 7 (70%) were successful.
  • CONCLUSION: The population of men with Leydig cell tumour of the testis is a population with decreased fertility before treatment of the tumour.
  • Resection of the tumour improves this situation, but 3 out of 10 patients remain infertile, indicating the need for semen storage measures in this population.
  • [MeSH-major] Fertility. Leydig Cell Tumor / surgery. Testicular Neoplasms / surgery

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  • (PMID = 17633998.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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17. Maratea KA, Ramos-Vara JA, Corriveau LA, Miller MA: Testicular interstitial cell tumor and gynecomastia in a rabbit. Vet Pathol; 2007 Jul;44(4):513-7
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  • [Title] Testicular interstitial cell tumor and gynecomastia in a rabbit.
  • Unilateral testicular interstitial (Leydig) cell tumor and gynecomastia were diagnosed in an adult male rabbit.
  • The interstitial cell tumor was a well-circumscribed, 2-mm diameter, pale tan nodule composed of a uniform population of polygonal cells.
  • Neoplastic interstitial cells exhibited diffuse, granular cytoplasmic staining with Melan A, a marker of steroid-producing cells in humans and dogs.
  • This is the first report of concurrent interstitial cell tumor and gynecomastia in a rabbit and also the first description of gynecomastia in this species.

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  • (PMID = 17606513.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Iwamoto I, Yanazume S, Fujino T, Yoshioka T, Douchi T: Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol; 2005 Mar;96(3):870-2
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  • [Title] Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome.
  • Testicular tumors often develop in patients with AIS, Sertoli cell tumor and seminoma being the most common types.
  • Leydig cell tumor in AIS is extremely rare.
  • CASE: A large abdominal tumor developed in a 73-year-old female patient.
  • The patient underwent the extirpation of bilateral gonads including the tumor, pelvic lymph nodes, omentum and appendix vermiformis.
  • The pathological diagnosis was malignant Leydig cell tumor of the left testis.
  • CONCLUSION: We reported an extremely rare case of malignant Leydig cell tumor developing in an elderly AIS patient.
  • [MeSH-major] Androgen-Insensitivity Syndrome / complications. Leydig Cell Tumor / complications. Ovarian Neoplasms / complications


19. Bhat GM, Lone MI, Alsolami S, Iqbal QM: Recurrent malignant Leydig cell tumor of testis: a case report with review of literature. Gulf J Oncolog; 2010 Jan;(7):42-5
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  • [Title] Recurrent malignant Leydig cell tumor of testis: a case report with review of literature.
  • Malignant Testicular Leydig Cell tumors (leydigomas) are extremely rare to occur and mostly carry a bad prognosis.
  • Here we describe the disease course of a middle aged patient with recurrent / metastatic Leydig cell tumor of testes, who needed repeated oncosurgical intervention and chemotherapy.
  • [MeSH-major] Leydig Cell Tumor / secondary. Neoplasm Recurrence, Local / pathology. Testicular Neoplasms / pathology

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  • (PMID = 20164008.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Kuwait
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20. Sugimoto K, Matsumoto S, Nose K, Kurita T, Uemura H, Park YC, Hanai J: A malignant Leydig cell tumor of the testis. Int Urol Nephrol; 2006;38(2):291-2
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  • [Title] A malignant Leydig cell tumor of the testis.
  • Histologically, Reinke's crystals and capsular invasion by tumor cells were found.
  • Final diagnosis, the tumor was a malignant Leydig cell tumor of the testis.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis

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  • (PMID = 16868700.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
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21. Biancani B, Lacave G, Magi GE, Rossi G: Ovarian interstitial cell tumor in a South American sea lion (Otaria flavescens). J Wildl Dis; 2010 Jul;46(3):1012-6
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  • [Title] Ovarian interstitial cell tumor in a South American sea lion (Otaria flavescens).
  • A case of an ovarian tumor is reported in an 8-yr-old South American sea lion (Otaria flavescens) kept in a marine park in Malta (35.57 degrees N, 14.25 degrees E).
  • The neoplasm was a solid mass of dense sheets and nests of round to polyhedral, irregularly shaped cells with abundant, finely vacuolated cytoplasm.
  • The tumor cells were positive for positive inhibin and vimentin and focally positive for cytokeratin by immunohistochemistry.
  • The neoplasm was diagnosed as an ovarian sex cord-stromal tumor, specifically an interstitial cell tumor.

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  • (PMID = 20688715.001).
  • [ISSN] 1943-3700
  • [Journal-full-title] Journal of wildlife diseases
  • [ISO-abbreviation] J. Wildl. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Sato K, Ueda Y, Sakurai A, Ishikawa Y, Okamoto SY, Ikawa H, Katsuda S: Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. Pathol Int; 2005 Jun;55(6):366-71
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  • [Title] Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor.
  • Large cell calcifying Sertoli cell tumor is a rare type of testicular tumor.
  • Reported herein is a Japanese patient with this tumor not associated with Carney's complex.
  • Macroscopically, the tumor was well circumscribed and had a maximum diameter of approximately 2 cm.
  • Histologically, the tumor was composed of large neoplastic cells with abundant eosinophilic cytoplasm with a tubular, trabecular, and solid arrangement and loose myxoid stroma with irregularly shaped calcification.
  • Immunohistochemically, the tumor cells were positive for vimentin, S-100 protein, calretinin, inhibin-alpha, melan-A, and CD10, and type IV collagen and laminin were observed in the extracellular matrix around the tumor cells.
  • The distributions of melan-A, CD10, and mitochondria were characteristically patchy; in contrast, they were diffusely distributed in the cytoplasm in a control case of Leydig cell tumor.
  • The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor.
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm. Calbindin 2. Child. Collagen Type V / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Inhibins / analysis. MART-1 Antigen. Male. Microscopy, Electron. Neoplasm Proteins / analysis. Neprilysin / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Testis / chemistry. Testis / pathology. Testis / ultrastructure. Vimentin / analysis

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  • (PMID = 15943795.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Collagen Type V; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.4.24.11 / Neprilysin
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23. Gozzi T, Flück ChE, Mullis PE: [Follow-up in a boy with Leydig cell tumor after selective surgery]. Praxis (Bern 1994); 2006 Feb 22;95(8):277-82
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  • [Title] [Follow-up in a boy with Leydig cell tumor after selective surgery].
  • [Transliterated title] Leydig-Zell-Tumor: Klinische Uberlegungen bei verfrühter Pubertätsentwicklung.
  • After a detailed examination a Leydig cell tumour was diagnosed.
  • Surgical exploration revealed an encapsulated tumour, 2.7 cm in length, which was selectively removed without orchidectomy.
  • We report on a long-term follow-up of a prepubertal boy after testis-sparing surgery for Leydig-cell-tumour.
  • [MeSH-major] Leydig Cell Tumor / surgery. Puberty, Precocious / etiology. Testicular Neoplasms / surgery

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  • (PMID = 16523992.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones
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24. Santoriello A, Benevento R, Petronella P, Perna G, Canonico S: Congenital adrenal hyperplasia and Leydig cell tumor of testis. Case report and review of literature. Ann Ital Chir; 2010 Nov-Dec;81(6):445-8
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  • [Title] Congenital adrenal hyperplasia and Leydig cell tumor of testis. Case report and review of literature.
  • This report describes a case of a monorchid patient suffering from Adrenogenital Syndrome and Leydig cell tumor of his testis.
  • This nodule had morphologic and immunohistochemical characteristics of a Leydig cell tumor, even found in the spermatic cord; those cells showed positivity to inibine, MART-1 and vimentine.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / complications. Leydig Cell Tumor / complications. Testicular Neoplasms / complications


25. Drut R, Wludarski S, Segatelli V, de Oliveira E, Barbosa A, Matheus A, Bacchi C: Leydig cell tumor of the testis with histological and immunohistochemical features of malignancy in a 1-year-old boy with isosexual pseudoprecocity. Int J Surg Pathol; 2006 Oct;14(4):344-8
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  • [Title] Leydig cell tumor of the testis with histological and immunohistochemical features of malignancy in a 1-year-old boy with isosexual pseudoprecocity.
  • The article reports the clinical, histopathological, and immunohistochemical findings of a 1-year-old boy presenting with isosexual pseudoprecocity attributable to a functioning Leydig cell tumor of the testis.
  • Malignancy features were also for the first time initially assessed using criteria, retrospectively developed from the literature, for metastasizing Leydig cell tumor.
  • Immunohistochemistry proved the cells of the tumor to be positive for inhibin, Melan-A, synaptophysin, cytokeratin, and calretinin and negative for S-100 and chromogranin A.
  • Notably, lipochrome and crystals of Reinke were not found in the tumor cells.
  • Although the neoplasm fulfilled the criteria for a potentially metastasizing Leydig cell tumor, there was no evidence of that event having occurred, perhaps as a result of early treatment or as indication that criteria developed for Leydig cell tumor of adults may not apply to children.
  • [MeSH-major] Leydig Cell Tumor / pathology. Puberty, Precocious / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm / genetics. Antigens, Neoplasm / metabolism. Calbindin 2. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Infant. Inhibins / genetics. Inhibins / metabolism. Keratins / genetics. Keratins / metabolism. MART-1 Antigen. Male. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. S100 Calcium Binding Protein G / genetics. S100 Calcium Binding Protein G / metabolism. Synaptophysin / genetics. Synaptophysin / metabolism

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  • (PMID = 17041205.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 0 / Synaptophysin; 57285-09-3 / Inhibins; 68238-35-7 / Keratins
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26. Nardo LG, Ray DW, Laing I, Williams C, McVey RJ, Seif MW: Ovarian Leydig cell tumor in a peri-menopausal woman with severe hyperandrogenism and virilization. Gynecol Endocrinol; 2005 Oct;21(4):238-41
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  • [Title] Ovarian Leydig cell tumor in a peri-menopausal woman with severe hyperandrogenism and virilization.
  • The authors report a case of Leydig cell tumor in a 46-year-old woman who first presented with severe clinical hyperandrogenism and associated complex medical history.
  • Histopathological examination revealed a 2 cm Leydig cell tumor within the right ovary.
  • Clinical presentation, biochemistry and imaging modalities should allow to detect androgen-secreting ovarian tumors, while selective venous sampling should be reserved for patients whom uncertainty remains.
  • The present case confirms that androgen-secreting ovarian tumors represent a diagnostic and therapeutic challenge.
  • [MeSH-major] Hyperandrogenism / complications. Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Virilism / complications

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  • (PMID = 16316848.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Androgens; 3XMK78S47O / Testosterone
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27. Diab DL, Faiman C, Siperstein AE, Grossman WF, Rabinowitz LO, Hamrahian AH: Virilizing ovarian Leydig cell tumor in a woman with subclinical Cushing syndrome. Endocr Pract; 2008 Apr;14(3):358-61
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  • [Title] Virilizing ovarian Leydig cell tumor in a woman with subclinical Cushing syndrome.
  • OBJECTIVE: To report the case of a patient with a virilizing ovarian Leydig cell tumor and subclinical Cushing syndrome attributable to an adrenal adenoma.
  • A laparoscopic adrenalectomy revealed an adrenal adenoma.
  • Bilateral oophorectomy revealed a 1.3-cm right ovarian Leydig cell tumor.
  • CONCLUSION: To our knowledge, this is the first case report of a virilizing ovarian Leydig cell tumor in a patient with subclinical Cushing syndrome.
  • [MeSH-major] Cushing Syndrome / diagnosis. Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Virilism / diagnosis
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Female. Humans. Middle Aged. Testosterone / blood


28. Stecher CW, Grønbaek K, Hasle H: A novel splice mutation in the TP53 gene associated with Leydig cell tumor and primitive neuroectodermal tumor. Pediatr Blood Cancer; 2008 Mar;50(3):701-3
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  • [Title] A novel splice mutation in the TP53 gene associated with Leydig cell tumor and primitive neuroectodermal tumor.
  • A 20-month-old boy presented with precocious puberty due to a Leydig cell tumor, and at the age of 6 years with a primitive neuroectodermal brain-tumor (PNET).
  • [MeSH-major] Genes, p53. Leydig Cell Tumor / genetics. Neoplasms, Multiple Primary / genetics. Neuroectodermal Tumors, Primitive / genetics. RNA Splice Sites / genetics. Supratentorial Neoplasms / genetics. Testicular Neoplasms / genetics

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17066464.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA Splice Sites
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29. Tavolini IM, Rossato M, Milani C, Dal Moro F: Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. Arch Ital Urol Androl; 2007 Sep;79(3):141-2
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  • [Title] Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence.
  • We report a case of a benign testicular Leydig-Cell Tumor (LCT) that deceived us because of an estradiol (E2) plasma levels elevation 27 months after radical orchiectomy in a body builder patient with habits of red meat abuse and no steroid assumption, without any sign of tumor recurrence.

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  • (PMID = 18041368.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 4TI98Z838E / Estradiol
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30. Matuszczyk A, Petersenn S, Lahner H, Haude M, Veit P, Becker JU, Kimmig R, Bockisch A, Mann K: [Leydig cell tumor as a cause of hirsutism in a postmenopausal woman]. Med Klin (Munich); 2007 Mar 15;102(3):259-62
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  • [Title] [Leydig cell tumor as a cause of hirsutism in a postmenopausal woman].
  • [Transliterated title] Androgenproduzierender Leydig-Zell-Tumor des Ovars als Ursache von Hirsutismus bei einer postmenopausalen Frau.
  • BACKGROUND: Hirsutism or virilization in postmenopausal women may be due to increased testosterone levels caused by an androgen-secreting tumor.
  • The preoperative localization of small ovarian or adrenal androgen-secreting tumors is difficult.
  • Selective catheterization and [(18)F]FDG-PET/CT investigation raised the suspicion of an androgen-secreting tumor of the right ovary.
  • Oophorectomy was performed, and a Leydig cell tumor of the right ovary was confirmed on histological examination.
  • CONCLUSION: Selective catheterization and [(18)F]FDG-PET investigation may aid the detection of androgen-secreting tumors.
  • [MeSH-major] Hirsutism / etiology. Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Testosterone / blood

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  • (PMID = 17345023.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 3XMK78S47O / Testosterone
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31. Miller MA, Hartnett SE, Ramos-Vara JA: Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. Vet Pathol; 2007 May;44(3):394-7
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  • [Title] Interstitial cell tumor and Sertoli cell tumor in the testis of a cat.
  • Testicular tumors are rarely reported in cats.
  • We describe a case of interstitial cell tumor and Sertoli cell tumor in a cat that developed aggressive behavior and inappropriate urination 7 years after it was obtained from a shelter as an allegedly castrated 2 year old.
  • Testes were not palpable, but the left testis was found in the scrotum by surgical exploration and was mostly replaced by the 2 tumors.
  • The interstitial cell tumor, but not the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with steroid production.
  • Neither tumor had metastasized.
  • [MeSH-major] Cat Diseases / pathology. Leydig Cell Tumor / veterinary. Sertoli Cell Tumor / veterinary

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  • (PMID = 17491086.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Arhan E, Cetinkaya E, Aycan Z, Aslan AT, Yücel H, Vidinlisan S: A very rare cause of virilization in childhood: ovarian Leydig cell tumor. J Pediatr Endocrinol Metab; 2008 Feb;21(2):181-3
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  • [Title] A very rare cause of virilization in childhood: ovarian Leydig cell tumor.
  • Ovarian Leydig cell tumor is a very rare cause of hyperandrogenism in childhood.
  • They are usually benign and surgical treatment is usually curative if the tumor is limited to the ovaries.
  • We present the youngest case of ovarian Leydig cell tumor reported in the literature who presented with hyperandrogenism that was satisfactorily resolved after resective surgery.
  • [MeSH-major] Leydig Cell Tumor / complications. Ovarian Neoplasms / complications. Virilism / etiology

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  • (PMID = 18422031.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Naik R, Upadhyaya K, Pai MR, Baliga PB, Nayak SK: Fine needle aspiration of metastatic malignant Leydig cell tumor of testis: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):624-5
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  • [Title] Fine needle aspiration of metastatic malignant Leydig cell tumor of testis: a case report.
  • The fine needle aspiration of the inguinal mass showed a highly cellular tumor composed of sheets and isolated, large round to polygonal cells with moderate pleomorphism.
  • A provisional diagnosis of metastasis probably of testicular tumour was made.
  • The orchidectomy showed a brown tumor replacing the entire testis and infiltrating the epididymis.
  • The histological features showed Leydig cell tumor without Reinke crystalloids.
  • [MeSH-major] Leydig Cell Tumor / secondary. Testicular Neoplasms / pathology

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  • (PMID = 17883165.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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34. van de Riet JE, Oelke M, van der Veen F, Visser H: [Gynaecomastia and male infertility as symptoms of a nonpalpable Leydig cell tumour]. Ned Tijdschr Geneeskd; 2006 Aug 19;150(33):1839-43
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  • [Title] [Gynaecomastia and male infertility as symptoms of a nonpalpable Leydig cell tumour].
  • Histopathological investigation showed benign hypertrophy.
  • Histology showed a benign Leydig cell tumour for which no further therapy was required.
  • Patients with severe male infertility or gynaecomastia are at a higher risk of developing a testicular neoplasm.
  • [MeSH-major] Estrogens / blood. Gynecomastia / diagnosis. Leydig Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis

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  • (PMID = 16967596.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Estrogens
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35. Carmignani L, Salvioni R, Gadda F, Colecchia M, Gazzano G, Torelli T, Rocco F, Colpi GM, Pizzocaro G: Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. J Urol; 2006 Nov;176(5):2040-3; discussion 2043
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases.
  • PURPOSE: The natural history of Leydig cell testicular tumors is not well known, and differentiation between malignant and benign forms is not easy.
  • We performed a retrospective multicenter evaluation of clinical and histological characteristics as well as followup of Leydig cell tumors.
  • MATERIALS AND METHODS: From 1990 to August 2004 surgery was performed on 24 Leydig cell tumors.
  • Before surgery all patients underwent clinical examination, tumor markers (alpha-fetoprotein, beta-human chorionic gonadotropin, lactate dehydrogenase), scrotal ultrasound and chest x-ray.
  • In 17 of 20 patients (85%) Leydig cell tumor was diagnosed on frozen section examination.
  • All definitive diagnoses interpreted the neoplasia as benign.
  • CONCLUSIONS: In our case study all Leydig cell tumors were interpreted as benign and long-term followup was negative.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis

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  • [CommentIn] J Urol. 2007 May;177(5):1955 [17437857.001]
  • (PMID = 17070249.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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36. Klotz RK, Müller-Holzner E, Fessler S, Reimer DU, Zervomanolakis I, Seeber B, Mattle V, Wildt L: Leydig-cell-tumor of the ovary that responded to GnRH-analogue administration - case report and review of the literature. Exp Clin Endocrinol Diabetes; 2010 May;118(5):291-7
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  • [Title] Leydig-cell-tumor of the ovary that responded to GnRH-analogue administration - case report and review of the literature.
  • Progressive hirsutism can be a symptom of an androgen-producing tumor, especially in postmenopausal women.
  • The histologic examination revealed a Leydig cell tumor in the hilus and stroma of the left ovary.
  • In this paper, polyglobulia, the metabolic and psychological changes due to hyperandrogenism are discussed, as well as the phenomenon that the tumor responded to a GnRH-analogue.
  • Such a response implies that the tumor is either under gonadotropin control or that GnRH analogues have direct effects via receptors on tumorous Leydig cells.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Leydig Cell Tumor / drug therapy. Ovarian Neoplasms / drug therapy. Triptorelin Pamoate / therapeutic use

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  • (PMID = 20198556.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Luteolytic Agents; 3XMK78S47O / Testosterone; 57773-63-4 / Triptorelin Pamoate; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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37. Wasniewska M, Raiola G, Teresa A, Galati MC, Zirilli G, Catena MA, Ascenti G, Arasi S, De Luca F: Gynecomastia disclosing diagnosis of Leydig cell tumour in a man with thalassemia, secondary hypogonadism and testis microlithiasis. Acta Biomed; 2009;80(3):286-8
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  • [Title] Gynecomastia disclosing diagnosis of Leydig cell tumour in a man with thalassemia, secondary hypogonadism and testis microlithiasis.
  • Due to the finding of a solid mass at left testis ultrasonography, monolateral testicular exeresis was performed and histology revealed a Leydig Cell Tumour and testicular microlithiasis.
  • Our report confirms the usefulness of scrotal ultrasonography for finding an occult testicular tumour in a patient with painful and recent onset bilateral gynecomastia and underlines: a) the important role of testosterone/estradiol ratio in the pathophysiology of gynecomastia;.
  • b) the questionable significance of testicular microlithiasis as marker of testis tumours;.
  • [MeSH-major] Gynecomastia / etiology. Leydig Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis

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  • (PMID = 20578425.001).
  • [ISSN] 0392-4203
  • [Journal-full-title] Acta bio-medica : Atenei Parmensis
  • [ISO-abbreviation] Acta Biomed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Heptanoates
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38. Owston MA, Ramos-Vara JA: Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. Vet Pathol; 2007 Nov;44(6):936-43
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  • [Title] Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog.
  • Mixed germ cell sex cord-stromal tumors (MGSCTs) of the testis are rare in dogs.
  • We describe the histopathology and immunohistochemical characteristics of an MGSCT associated with a Leydig cell tumor in a cryptorchid testis.
  • Markers that labeled mainly germ cells and few or no Sertoli or Leydig cells were calretinin, KIT, and PGP 9.5.
  • E-cadherin, GATA-4, inhibin-alpha (INH-alpha), and neuron-specific enolase (NSE) were predominantly detected in Sertoli cells, whereas melan A was particularly expressed in Leydig cells and vimentin in all three cell types.
  • OCT3/4 was not detected in any cell type.
  • Although more cases of canine MGSCT need to be examined, our results suggest that an immunohistochemical panel of E-cadherin, GATA-4, INH-alpha, KIT, NSE, PGP 9.5, and melan A will help distinguish the three main cell types in canine testicular germ cell and sex cord-stromal tumors.
  • [MeSH-major] Dog Diseases / pathology. Leydig Cell Tumor / veterinary. Sex Cord-Gonadal Stromal Tumors / veterinary. Testicular Neoplasms / veterinary

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  • (PMID = 18039910.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Sanz OA, Martinez PR, Guarch RT, Goñi MJ, Alcazar JL: Bilateral Leydig cell tumour of the ovary: a rare cause of virilization in postmenopausal patient. Maturitas; 2007 Jun 20;57(2):214-6
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  • [Title] Bilateral Leydig cell tumour of the ovary: a rare cause of virilization in postmenopausal patient.
  • BACKGROUND: Leydig cell tumours of the ovary are very rare benign neoplasms, frequently associated with symptoms of virilisation, in postmenopausal patients.
  • Only four cases of bilateral Leydig tumours have been reported in the literature.
  • A CT scan demonstrated adrenal glands and ovaries without tumour.
  • RESULT: The pathological finding was a bilateral Leydig cell tumour, measuring 15 mm in the right ovary and 3 mm in the left ovary.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Virilism / etiology

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  • (PMID = 17289310.001).
  • [ISSN] 0378-5122
  • [Journal-full-title] Maturitas
  • [ISO-abbreviation] Maturitas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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40. Kayemba-Kays S, Fromont-Hankard G, Lettelier G, Gabriel S, Levard G: Leydig cell tumour revealed by bilateral gynecomastia in a 15-year-old adolescent: a patient report. J Pediatr Endocrinol Metab; 2010 Nov;23(11):1195-9
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  • [Title] Leydig cell tumour revealed by bilateral gynecomastia in a 15-year-old adolescent: a patient report.
  • Its course is spontaneously benign with resolution occurring by age 18 years.
  • Association with Leydig cell tumour is more common in adults, so that scrotal ultrasound is part of routine work up.
  • A 15-years-old boy with Leydig cell tumour revealed by bilateral gynecomastia is reported.
  • [MeSH-major] Gynecomastia / etiology. Leydig Cell Tumor / complications. Testicular Neoplasms / complications

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  • (PMID = 21284336.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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41. Suardi N, Strada E, Colombo R, Freschi M, Salonia A, Lania C, Cestari A, Carmignani L, Guazzoni G, Rigatti P, Montorsi F: Leydig cell tumour of the testis: presentation, therapy, long-term follow-up and the role of organ-sparing surgery in a single-institution experience. BJU Int; 2009 Jan;103(2):197-200
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  • [Title] Leydig cell tumour of the testis: presentation, therapy, long-term follow-up and the role of organ-sparing surgery in a single-institution experience.
  • OBJECTIVE: To report our single-centre experience of patients with Leydig cell tumour (LCT) of the testis, which represents the most frequent interstitial neoplasm of the testis, and for which the natural history and therapy are debated.
  • The mean (range) diameter of the tumour was 16.5 (6-68) mm.
  • Surgical removal of the tumour is not always associated with resolution of symptoms and abnormal laboratory values.
  • [MeSH-major] Leydig Cell Tumor / surgery. Orchiectomy / methods. Testicular Neoplasms / surgery. Testis / surgery

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  • (PMID = 18990169.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-67-9 / Luteinizing Hormone
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42. Petkovic V, Salemi S, Vassella E, Karamitopoulou-Diamantis E, Meinhardt UJ, Flück CE, Mullis PE: Leydig-cell tumour in children: variable clinical presentation, diagnostic features, follow-up and genetic analysis of four cases. Horm Res; 2007;67(2):89-95
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  • [Title] Leydig-cell tumour in children: variable clinical presentation, diagnostic features, follow-up and genetic analysis of four cases.
  • BACKGROUND: Testicular tumours are relatively uncommon in infants and children, accounting for only 1-2% of all paediatric solid tumours.
  • Of these approximately 1.5% are Leydig-cell tumours.
  • AIMS/METHODS: In this report, the clinical variability of Leydig-cell tumours in four children is described.
  • The LHR-, gsp-, gip2- and CDK4 genes were investigated to establish the possible molecular pathogenesis of the variable phenotype of the Leydig-cell tumours.
  • RESULTS: No activating mutations in these genes were found in the four Leydig-cell tumours studied.
  • Therefore, the absence of activating mutations in LHR, as well as in both the 'hot spot' regions for activating mutations within the G-alpha subunits and in the regulatory 'hot spot' on the CDK4 genes in these tumours indicates molecular heterogeneity among Leydig-cell tumours.
  • CONCLUSION: Four children with a variable phenotype caused by Leydig-cell tumours are described.
  • The lessons learnt from these clinically variable cases are: perform ultrasound early and most importantly, consider discrepancies between testicular swelling, tumour size and androgen production.
  • [MeSH-major] Leydig Cell Tumor. Testicular Neoplasms

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17047343.001).
  • [ISSN] 0301-0163
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Androgens
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43. Ohnuma A, Yoshida T, Takahashi N, Akema S, Kumagai M, Chiba Y, Kashimoto Y, Kuwahara M, Nakashima N, Harada T: Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse. J Vet Med Sci; 2010 May;72(5):661-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse.
  • Leydig cell tumors with spindle-shaped cells are very rare in humans and animals.
  • We report that an 84-week-old male CD-1 mouse had a malignant Leydig cell tumor characterized by proliferation of oval to spindle-shaped cells with or without fat deposition, and with a storiform pattern.
  • These cells were immunopositive for inhibin and S-100, and negative for the androgen receptor, thereby suggesting that they may have differentiated from Leydig cells.
  • This differentiation from Leydig cells was further confirmed by the immunopositivity of these cells for nestin and alpha-smooth muscle actin, both of which are known to be expressed in the stem/progenitor cells that differentiate into Leydig cells.
  • These findings suggest that the tumor is most probably a malignant spindle-cell-type Leydig cell tumor.

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  • (PMID = 20075603.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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44. Goto HG, Nishizawa Y, Katayama H, Murashima T, Yamasaki M, Tanigaki Y, Kimura S, Fushiki S, Nishizawa Y: Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. Oncol Rep; 2007 Jan;17(1):225-32
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  • [Title] Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene.
  • For estrogen-responsive B-1F cells, established from estrogen-responsive mouse Leydig cell tumor, it has been reported that the 5-lipoxygenase (5-LOX) metabolic pathway appears to be associated with cell growth.
  • The addition of 5-LOX inhibitor 2-(12-hydroxydodeca-5,10-diyl)-3,5,6-trimethyl-1,4-benzoquinone (AA861) to the medium resulted in a dose-dependent increase in cell yield as described previously.
  • When the growth of the palpable tumors was measured, AA861 had stimulated in vivo tumor growth in adult male mouse inoculated B-1F cells.
  • When LTD4 was added in the culture medium, the increasing concentrations of LTD4 resulted in a significant inhibition of cell yields of E2-treated B-1F cells.
  • [MeSH-major] Apoptosis / drug effects. Estradiol / pharmacology. Leukotriene D4 / pharmacology. Leydig Cell Tumor / pathology
  • [MeSH-minor] Animals. Arachidonate 5-Lipoxygenase / biosynthesis. Arachidonate 5-Lipoxygenase / genetics. Arachidonate 5-Lipoxygenase / metabolism. Arachidonic Acid / antagonists & inhibitors. Arachidonic Acid / metabolism. Benzoquinones / pharmacology. Cell Growth Processes / drug effects. Lipoxygenase Inhibitors. Male. Mice. Mice, Inbred BALB C. Oligonucleotides, Antisense / genetics. Oligonucleotides, Antisense / pharmacology. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Tumor Cells, Cultured

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  • (PMID = 17143502.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Benzoquinones; 0 / Lipoxygenase Inhibitors; 0 / Oligonucleotides, Antisense; 0 / RNA, Messenger; 27YG812J1I / Arachidonic Acid; 4TI98Z838E / Estradiol; 73836-78-9 / Leukotriene D4; 80809-81-0 / 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
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45. Monteagudo LV, Arruga MV, Bonafonte JI, Ordás M, Whyte A, Gallego M, Bascuas JA, Sierra I: Bilateral Leydig cell tumor in a six-year-old intersex goat affected by Polled Intersex Syndrome. Vet Pathol; 2008 Jan;45(1):42-5
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  • [Title] Bilateral Leydig cell tumor in a six-year-old intersex goat affected by Polled Intersex Syndrome.
  • An advanced Leydig cell tumor, resulting in almost total destruction of the intratesticular structures, was also observed.
  • Leydig cell tumors usually produce testosterone.
  • [MeSH-major] Disorders of Sex Development / veterinary. Goat Diseases / diagnosis. Leydig Cell Tumor / veterinary. Ovarian Neoplasms / veterinary

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  • (PMID = 18192573.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Butros LJ, Phillip S, Chou A, Meyers PA, Huvos AG, Healey JH, Russo P, Gorlick RG: Leydig cell tumor after treatment for Ewing's sarcoma. Pediatr Blood Cancer; 2007 Dec;49(7):1008-10
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  • [Title] Leydig cell tumor after treatment for Ewing's sarcoma.
  • Leydig cell tumors account for 3% of testicular tumors and have never been reported after treatment for Ewing's sarcoma.
  • We report the unusual occurrence of a patient who developed a Leydig cell tumor of the testis 18 years after successful treatment for Ewing's sarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Leydig Cell Tumor / diagnosis. Neoplasms, Second Primary / diagnosis. Sarcoma, Ewing / diagnosis. Testicular Neoplasms / diagnosis

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  • [Copyright] 2007 Wiley-Liss, Inc
  • (PMID = 16526050.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Carpino A, Rago V, Pezzi V, Carani C, Andò S: Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor. Eur J Endocrinol; 2007 Aug;157(2):239-44
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  • [Title] Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor.
  • A Leydig cell tumor is a rare neoplasm, deriving from the interstitial cells, whose pathogenesis has not been still defined.
  • Leydig cells of normal adult testis are known as physiological targets for estrogens.
  • However, some studies on transgenic rodents suggest a role of estrogens in the development of Leydig cell hyperplasia and Leydig cell tumor.
  • Therefore, with the aim to evaluate a possible link between estrogens and testicular tumorigenesis, this study investigated the expression of aromatase and estrogen receptors (ERalpha, ERbeta(1), ERbeta(2)) in testes from two patients with Leydig cell tumor.
  • These findings were confirmed by western blot analysis of tumor extracts detecting a 55 kDa P450arom, a 67 kDa ERalpha band, a 59 kDa ERbeta(1) band, and a 53 kDa ERbeta(2) band.
  • The pattern of ER expression in neoplastic cells appears different from that of control Leydig cells exhibiting only ERbeta(1) and ERbeta(2) isoforms.
  • The authors hypothesize how the high estrogen production could play a role in the neoplastic transformation of Leydig cells, while the exclusive presence of ERalpha in tumoral cells could amplify estradiol-17beta signaling contributing to the tumor cell growth and progression.

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  • (PMID = 17656605.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; EC 1.14.14.1 / Aromatase
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48. Di Tonno F, Tavolini IM, Belmonte P, Bertoldin R, Cossaro E, Curti P, D'Incà G, Fandella A, Guaitoli P, Guazzieri S, Mazzariol C, North-Eastern Uro-Oncological Group, Italy: Lessons from 52 patients with leydig cell tumor of the testis: the GUONE (North-Eastern Uro-Oncological Group, Italy) experience. Urol Int; 2009;82(2):152-7
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  • [Title] Lessons from 52 patients with leydig cell tumor of the testis: the GUONE (North-Eastern Uro-Oncological Group, Italy) experience.
  • INTRODUCTION: The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis.
  • We considered 52 patients (54 tumors, 2 bilateral) whose ages ranged from 13 to 70 years (mean 36).
  • Of the treatments performed, 52 were orchiectomies and 2 were enucleations (unfavorable pathology in only 2 tumors).
  • There were 5 lymphadenectomies (retroperitoneal lymph node dissections): 2 for suspected stage II disease and 1 each for unfavorable pathology, bilateral disease and associated Sertoli tumor (pathology: pN0 in all cases).
  • [MeSH-major] Leydig Cell Tumor / surgery. Lymph Node Excision. Orchiectomy. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Humans. Italy. Male. Middle Aged. Neoplasm Metastasis. Patient Selection. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19322000.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Switzerland
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49. Ozgun MT, Batukan C, Turkyilmaz C, Dolanbay M, Mavili E: Selective ovarian vein sampling can be crucial to localize a Leydig cell tumor: an unusual case in a postmenopausal woman. Maturitas; 2008 Nov 20;61(3):278-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selective ovarian vein sampling can be crucial to localize a Leydig cell tumor: an unusual case in a postmenopausal woman.
  • Leydig cell tumors of the ovary are very rare, frequently associated with symptoms of virilization in postmenopausal patients.
  • It is sometimes difficult to localize the tumor precisely even with modern imaging techniques.
  • Extensive pre-operative evaluations included transvaginal ultrasound, abdominal computed tomography and magnetic resonance imaging failed to localize the tumor.
  • Microscopic examination of the left ovary revealed a Leydig cell tumor.
  • In conclusion, when the precise location of the tumor is not determined pre-operatively, SOVHS may be valuable to make accurate diagnosis.
  • [MeSH-major] Leydig Cell Tumor / blood. Ovarian Neoplasms / blood. Testosterone / blood

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  • (PMID = 18930614.001).
  • [ISSN] 0378-5122
  • [Journal-full-title] Maturitas
  • [ISO-abbreviation] Maturitas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 3XMK78S47O / Testosterone
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50. Gonzalez M, Merlani P, Egger JF, Pugin F, Morel P: Hemorrhagic shock caused by rupture of an intra-abdominal leydig cell tumour: case report. Case Rep Gastroenterol; 2007;1(1):53-8

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  • [Title] Hemorrhagic shock caused by rupture of an intra-abdominal leydig cell tumour: case report.
  • The rupture of an intra-abdominal testicular neoplasm is a rare cause of acute abdomen and massive intra-abdominal haemorrhage.
  • We report the case of a 70-year-old male presenting a massive intra-abdominal bleeding caused by a Leydig cell tumour in an undescended testis.
  • The clinical details and pathology of this rare testicular tumour are discussed.

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  • [Cites] Radiology. 2004 May;231(2):388-92 [15128985.001]
  • [Cites] Radiology. 1987 Jul;164(1):169-73 [2884693.001]
  • [Cites] Br J Urol. 1969 Feb;41(1):83-8 [4388247.001]
  • [Cites] Am J Surg Pathol. 1998 Nov;22(11):1361-7 [9808128.001]
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  • (PMID = 21487472.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3073788
  • [Keywords] NOTNLM ; Cryptorchidism / Hemorrhagic shock / Leydig cell tumour
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51. Cánovas Ivorra JA, Castillo Gimeno JM, Michelena Barcena J, Alberto Ramírez D, Vera Román J: [Leydig cell tumor. Case report and review of the literature]. Arch Esp Urol; 2006 Apr;59(3):293-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Leydig cell tumor. Case report and review of the literature].
  • [Transliterated title] Tumor de células de Leydig. A propósito de un nuevo caso y revisión de la literatura.
  • OBJECTIVE: To report a new case of the rare Leydig cell tumor, and to perform bibliographic review.
  • METHODS: We report the case of a 38-year-old male with the clinical and ultrasound diagnosis of testicular tumor, and normal hormonal and extension studies.
  • He underwent inguinal radical orchyectomy and the pathology report of the specimen showed a Leydig cell tumor.
  • RESULTS: The patient does not show evidence of recurrence after chest x-rays, abdominal-pelvic CT scan, ultrasound of the contralateral testis, and tumor markers.
  • CONCLUSIONS: We recommend a long-term follow-up with contralateral testicle ultrasound, CT scan, chest x-ray, and tumor markers.
  • [MeSH-major] Leydig Cell Tumor. Testicular Neoplasms

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  • (PMID = 16724717.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 13
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52. Colecchia M, Nistal M, Gonzalez-Peramato P, Carmignani L, Salvioni R, Nicolai N, Regadera J: Leydig cell tumor and hyperplasia: a review. Anal Quant Cytol Histol; 2007 Jun;29(3):139-47
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  • [Title] Leydig cell tumor and hyperplasia: a review.
  • We describe the role of Leydig cells in normal, hyperplastic and neoplastic testis.
  • Recent acquisitions on etiology and pathobiology of Leydig cell proliferations, unusual microscopic presentations and clinical and morphologic features predictive of malignancy are reported.

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  • (PMID = 17672373.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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53. Agras K, Tuncel A, Aslan Y, Kulacoglu S, Atan A: Adolescent renomedullary interstitial cell tumor: a case report. Tumori; 2005 Nov-Dec;91(6):555-7
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  • [Title] Adolescent renomedullary interstitial cell tumor: a case report.
  • The patient underwent a right simple nephrectomy and after histopathological examination was found to have a renomedullary interstitial cell tumor of the right kidney.
  • This tumor is common in patients older than 50 years, whereas our patient was very young.
  • The diagnosis of this small tumor is not possible by conventional radiological techniques and histopathological examination is mandatory for its diagnosis.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Leydig Cell Tumor / diagnosis

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  • (PMID = 16457157.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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54. Handa U, Sood T, Punia RS: Testicular Leydig cell tumor diagnosed on fine needle aspiration. Diagn Cytopathol; 2010 Sep;38(9):682-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular Leydig cell tumor diagnosed on fine needle aspiration.
  • We report on the cytopathologic findings of a Leydig cell tumor of the testis in an adult male with no evidence of endocrine dysfunction.
  • The cytologic smears were cellular and showed tumor cells arranged singly, as well as in dyscohesive clusters.
  • The tumor cells were large, round to polygonal, with indistinct cytoplasmic margins and pale, abundant, granular to vacuolated cytoplasm.
  • The present case was of interest because of the scarcity of literature on the cytodiagnosis of this tumor.
  • The use of FNAC for diagnosis may vitiate the need for more invasive biopsy procedures in the preoperative diagnosis of this rare testicular tumor.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Leydig Cell Tumor / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology. Testis / pathology

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 20737589.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Demidov VN, Lipatenkova J, Vikhareva O, Van Holsbeke C, Timmerman D, Valentin L: Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol; 2008 Jan;31(1):85-91
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  • [Title] Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors.
  • OBJECTIVE: To describe the clinical history and ultrasound findings in women with ovarian Sertoli cell, Sertoli-Leydig cell and Leydig cell tumors.
  • METHODS: Women with a histological diagnosis of Sertoli cell tumor, Sertoli-Leydig cell tumor or Leydig cell tumor who had undergone preoperative ultrasound examination were identified from the databases of each of three participating ultrasound centers.
  • The tumors were characterized on the basis of ultrasound images, ultrasound reports and research protocols (when applicable) using the terms and definitions published by the International Ovarian Tumor Analysis (IOTA) group.
  • RESULTS: Of 22 patients identified, 15 had Sertoli-Leydig cell tumors, two had Sertoli cell tumors and five had Leydig cell tumors.
  • Twenty-two (96%) of 23 tumors (one woman had bilateral tumors) contained a solid component; 16 (70%) were purely solid.
  • Pattern recognition showed that the Leydig cell tumors were small solid tumors (four of five had a largest diameter of 1-3 cm) and the two Sertoli cell tumors were somewhat larger solid tumors (4 cm and 7 cm); the Sertoli-Leydig cell tumors were either small (3-4 cm) or medium-sized (6-7 cm) solid tumors, or multilocular solid tumors of any size (3-18 cm) with purely solid areas mixed with areas of innumerable closely packed small cyst locules.
  • CONCLUSIONS: On the basis of endocrine symptoms, the woman's age and ultrasound findings, it should be possible to suggest a correct preoperative diagnosis of Sertoli cell, Sertoli-Leydig cell or Leydig cell tumors in many cases.
  • [MeSH-major] Ovarian Neoplasms / ultrasonography. Sertoli-Leydig Cell Tumor / ultrasonography
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Differentiation / physiology. Female. Humans. Middle Aged. Pattern Recognition, Automated / methods. Prognosis

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  • [Copyright] Copyright (c) 2007 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 18098335.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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56. Dickerson RD, Putman MJ, Black ME, Pinto KR, Diamond NG, Marynick S, Pinto AB: Selective ovarian vein sampling to localize a Leydig cell tumor. Fertil Steril; 2005 Jul;84(1):218
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selective ovarian vein sampling to localize a Leydig cell tumor.
  • OBJECTIVE: To describe a patient with recent onset of rapidly progressive virilization who was diagnosed with an androgen-secreting tumor of the left ovary, localized by selective ovarian vein catheterization and hormonal sampling (SOVHS).
  • PATIENT(S): A 32-year-old woman presenting with progressive virilization over a period of 4 months was found to have a Leydig cell tumor of the left ovary.
  • Selective ovarian vein sampling was performed to localize the tumor.
  • RESULT(S): Patient's ovarian tumor removed laparoscopically was reported to be a Leydig cell tumor.
  • Rapid decreases in free and total T followed tumor removal.
  • CONCLUSION(S): Selective ovarian vein catheterization and hormonal sampling is an effective diagnostic modality that can help localize small ovarian tumors.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Ovary / blood supply

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  • (PMID = 16009186.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Loeser A, Vergho DC, Katzenberger T, Brix D, Kocot A, Spahn M, Gerharz EW, Riedmiller H: Testis-sparing surgery versus radical orchiectomy in patients with Leydig cell tumors. Urology; 2009 Aug;74(2):370-2
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  • [Title] Testis-sparing surgery versus radical orchiectomy in patients with Leydig cell tumors.
  • OBJECTIVES: To compare retrospectively the outcome of testis-sparing surgery (TSS) to radical orchiectomy (RO) in patients with Leydig cell tumor (LCT).
  • All but 1 tumor could be detected by ultrasonography.
  • Eight patients underwent RO (mean age at surgery 42 years [27-61]; median tumor size 12.9 mm [10-25]) and the remaining 8 underwent TSS (mean age at surgery 34 years [18-49]; median tumor size 8.6 mm [4-23]).
  • Another patient underwent surgical exploration of the testis 31 months after ipsilateral TSS because of a suspicious lesion identified in ultrasonography; a tumor was ruled out by histopathology.
  • [MeSH-major] Leydig Cell Tumor / surgery. Orchiectomy. Testicular Neoplasms / surgery

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  • (PMID = 19646624.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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58. Samoladas EP, Anbar AS, Lucas JD, Fotiadis H, Chalidis BE: Spinal cord compression by a solitary metastasis from a low grade leydig cell tumour: a case report and review of the literature. World J Surg Oncol; 2008;6:75
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  • [Title] Spinal cord compression by a solitary metastasis from a low grade leydig cell tumour: a case report and review of the literature.
  • BACKGROUND: Leydig tumour is rare and there are only three cases with metastatic disease reported.
  • The histology of the excised tumour was identical to the primary.
  • CONCLUSION: This is the first case in English literature, which shows that spinal metastases could occur even in the early stage of Leydig cell tumour, without other organs involvement.
  • [MeSH-major] Leydig Cell Tumor / secondary. Spinal Cord Compression / etiology. Spinal Neoplasms / secondary. Testicular Neoplasms / pathology

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  • [Cites] Neurosurgery. 1987 Nov;21(5):676-80 [3696401.001]
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  • (PMID = 18616814.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2483278
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59. Sengupta S, Chatterjee U, Sarkar K, Chatterjee S, Kundu A: Leydig cell tumor: a report of two cases with unusual presentation. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):796-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leydig cell tumor: a report of two cases with unusual presentation.
  • Leydig cell tumors (LCTs) are rare testicular tumors.
  • They constitute 1-3% of all testicular tumors.
  • We report two cases of LCT, one benign and the other one malignant, representing both ends of the spectrum.
  • The case of benign LCT presented with infertility and was found to have azoospermia, and subsequently underwent orchidectomy.
  • Histopathologic examination revealed the presence of a benign LCT.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Leydig Cell Tumor / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology

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  • (PMID = 21045421.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Vimentin
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60. Engohan-Aloghe C, Aubain Sommerhausen Nde S, Noël JC: Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor. Int J Gynecol Pathol; 2009 Nov;28(6):579-83
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  • [Title] Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor.
  • Desmoplastic small round cell tumor (DSRCT) is a rare aggressive tumor primarily involving serosal surfaces in adolescents and young men.
  • We report here a variant of DSRCT involving the ovaries that mimics the Sertoli-Leydig cell tumor in a 21-year-old woman complaining of abdominal pain.
  • Frozen section examination identified the right ovarian mass as a poorly differentiated Sertoli-Leydig cell tumor.
  • The surgically resected tumor and left ovary and omentum implants found during laparoscopy were diagnosed as DSRCT with Leydig cell hyperplasia.
  • Immunohistochemically, the tumor cells were negative for epithelial markers but were positive for calretinin and inhibin.
  • This case showed that DSRCT with unusual immunohistochemical profiles and Leydig cells hyperplasia pose a diagnostic challenge.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Leydig Cells / pathology. Ovarian Neoplasms / pathology. Sertoli-Leydig Cell Tumor / pathology

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  • (PMID = 19851210.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 57285-09-3 / Inhibins
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61. Yang HY, Leu SF, Wang YK, Wu CS, Huang BM: Cordyceps sinensis mycelium induces MA-10 mouse Leydig tumor cell apoptosis by activating the caspase-8 pathway and suppressing the NF-kappaB pathway. Arch Androl; 2006 Mar-Apr;52(2):103-10

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  • [Title] Cordyceps sinensis mycelium induces MA-10 mouse Leydig tumor cell apoptosis by activating the caspase-8 pathway and suppressing the NF-kappaB pathway.
  • CS can inhibit tumor growth and induce tumor cell apoptosis.
  • CS induced MA-10 mouse Leydig tumor cell death, but the anti-tumor mechanisms are not fully understood.
  • Western blot analysis showed that 3 hours of CS treatment caused an increase in caspase-3 and -8 expressions only, which provided further evidence for the involvement of caspase-3 and -8 in CS-induced MA-10-cell apoptosis.
  • CS induces MA-10 cell apoptosis by activating caspase-8-dependent and caspase-9-independent pathways and downregulating NF-?B protein expression.
  • [MeSH-major] Apoptosis / drug effects. Biological Products / pharmacology. Cordyceps. Leydig Cell Tumor / drug therapy
  • [MeSH-minor] Animals. Caspase 8. Caspases / metabolism. Cell Line, Tumor. Gene Expression Regulation / drug effects. Male. Mice. Mycelium. NF-kappa B / metabolism

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  • (PMID = 16443586.001).
  • [ISSN] 0148-5016
  • [Journal-full-title] Archives of andrology
  • [ISO-abbreviation] Arch. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biological Products; 0 / NF-kappa B; EC 3.4.22.- / Casp8 protein, mouse; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases
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62. Sangkhathat S, Kanngurn S, Jaruratanasirikul S, Tubtawee T, Chaiyapan W, Patrapinyokul S, Chiengkriwate P: Peripheral precocious puberty in a male caused by Leydig cell adenoma harboring a somatic mutation of the LHR gene: report of a case. J Med Assoc Thai; 2010 Sep;93(9):1093-7
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  • [Title] Peripheral precocious puberty in a male caused by Leydig cell adenoma harboring a somatic mutation of the LHR gene: report of a case.
  • While a germline activating mutation of the luteinizing hormone receptor (LHR) gene is known to cause autonomous production of testosterone from testicular Leydig cells in male-limited precocious puberty, only a few studies have addressed the role of somatic LHR mutation in testicular pathology.
  • Examination revealed asymmetrical testicular volume, following which a left testicular tumor was detected through ultrasonography.
  • A left orchiectomy was performed, and histopathology revealed a well-circumscribed Leydig cell tumor Molecular study of the exon 11 of the LHR gene revealed a missense mutation at the nucleotide position 1,732, leading to a substitution of histidine for aspartic acid at codon 578.
  • Interestingly, the substitution was consistent with all previously reported LHR alteration in pediatric Leydig cell adenoma, but which had never before been reported in male-limited precocious puberty, suggesting that the mutation is a molecular signature of the adenoma.
  • [MeSH-major] Leydig Cell Tumor / genetics. Mutation, Missense. Puberty, Precocious / genetics. Receptors, LH / genetics. Testicular Neoplasms / genetics
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Adenoma / surgery. Child. Exons. Humans. Male. Orchiectomy. Testosterone / analysis. Testosterone / genetics. Treatment Outcome

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  • (PMID = 20873084.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Receptors, LH; 3XMK78S47O / Testosterone
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63. Méndez-Gallart R, Bautista A, Estevez E, Barreiro J, Evgenieva E: Leydig Cell Testicular Tumour Presenting as Isosexual Precocious Pseudopuberty in a 5 Year-old Boy with No Palpable Testicular Mass. Clin Pediatr Endocrinol; 2010 Jan;19(1):19-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leydig Cell Testicular Tumour Presenting as Isosexual Precocious Pseudopuberty in a 5 Year-old Boy with No Palpable Testicular Mass.
  • Leydig cell testicular tumors are very rare in children and cause isosexual precocious puberty.
  • We report on a 5-yr-old boy with a Leydig cell tumor of the testis presented with isosexual precocious puberty but no scrotal palpable mass.
  • To our knowledge, this is the first reported Leydig cell tumor in a boy without palpable scrotal mass.

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  • (PMID = 23926374.001).
  • [ISSN] 0918-5739
  • [Journal-full-title] Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
  • [ISO-abbreviation] Clin Pediatr Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3687613
  • [Keywords] NOTNLM ; Leydig-cell tumor / neoplasm / precocious puberty / testicular / testis
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64. Cajaiba MM, Reyes-Múgica M, Rios JC, Nistal M: Non-tumoural parenchyma in Leydig cell tumours: pathogenetic considerations. Int J Androl; 2008 Jun;31(3):331-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-tumoural parenchyma in Leydig cell tumours: pathogenetic considerations.
  • Little is known about the pathogenesis of Leydig cell tumours (LCTs) of the testis.
  • The observation of several associated dysgenetic features in the non-tumoural parenchyma and in the contralateral testes of men with testicular germ cell neoplasms has served as the basis to propose that there may be a common mechanism for different male reproductive disorders.
  • Parameters as Leydig cell hyperplasia (LCHY), qualitative evaluation of the germinal epithelium and spermatogenesis, the presence of Sertoli cell-only tubules (SCOT), and the Sertoli cell nuclear morphology were consistently assessed in all cases.
  • SCOT associated with Sertoli cell dysgenetic morphology was the most frequent finding, present in 50% of the cases.
  • The abnormalities in spermatogenesis observed here are likely to represent consequences of either tumour compression or abnormal hormonal production.
  • [MeSH-major] Leydig Cell Tumor / pathology. Testicular Neoplasms / pathology. Testis / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Nucleus Shape. Humans. Hyperplasia. Leydig Cells / pathology. Male. Middle Aged. Sertoli Cells / pathology. Spermatogenesis

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  • (PMID = 17573846.001).
  • [ISSN] 1365-2605
  • [Journal-full-title] International journal of andrology
  • [ISO-abbreviation] Int. J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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65. Hribar KP, Warner NE, Sherrod AE: Cytologic identification of reinke crystalloids in scrapings and imprints of fresh testicular tumors: a simple and rapid technique for intraoperative use. Arch Pathol Lab Med; 2005 Mar;129(3):e65-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic identification of reinke crystalloids in scrapings and imprints of fresh testicular tumors: a simple and rapid technique for intraoperative use.
  • Although not required for the diagnosis, crystalloids of Reinke are pathognomonic for Leydig cell tumor.
  • We tested the efficacy of touch imprints and scrape smears for the identification of crystalloids in 2 cases of Leydig cell tumor of the testis.
  • Intraoperative smears of the tumors yielded abundant crystals.
  • We speculate that the process of scraping, and to a lesser extent touch imprinting, disrupts the cytoplasm of the Leydig cells and releases the crystalloids.
  • We conclude that cytologic testing is an effective method of identifying crystalloids of Reinke in Leydig cell tumors of the testis.
  • [MeSH-major] Crystallization. Cytodiagnosis / methods. Leydig Cell Tumor / diagnosis. Leydig Cell Tumor / surgery. Testicular Neoplasms / diagnosis. Testicular Neoplasms / surgery

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  • [CommentIn] Arch Pathol Lab Med. 2006 Jun;130(6):765-6 [16740025.001]
  • (PMID = 15737059.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Teixeira RL, Rossini A, Paim NP: [Testicular tumors in childhood]. Rev Col Bras Cir; 2009 Feb;36(1):85-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Testicular tumors in childhood].
  • Testicular and paratesticular prepuberal tumors are rare.
  • They represent around 1% of the total of tumors of infancy.
  • They subdivide in 2 groups: germ cells tumors and non germ cells tumors, being able to occur in all the ages, and about 75% are malignant, and about 19% of these they present metastasis.
  • The tumors of germ cells tumors represent 60 75% of the tumors testiculars in infancy, having as main example the yolk sac tumor (65% of the neoplasms), followed for teratomas (14%); although some works to exist where teratoma, if presents as most common .The non germ cells tumors include the Leydig cell tumor and Sertoli cell tumor.
  • The Leydig cell tumor, are most frequent between the non germ cells tumors testicular.
  • This review article on epidemiology, diagnosis and treatment of to testicular and to paratesticular tumors in child.
  • [MeSH-minor] Child. Endodermal Sinus Tumor / pathology. Humans. Male. Teratoma / pathology

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  • (PMID = 20076873.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 35
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67. Ashley RA, McGee SM, Isotaolo PA, Kramer SA, Cheville JC: Clinical and pathological features associated with the testicular tumor of the adrenogenital syndrome. J Urol; 2007 Feb;177(2):546-9; discussion 549
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and pathological features associated with the testicular tumor of the adrenogenital syndrome.
  • PURPOSE: Testicular tumor of the adrenogenital syndrome is a rare clinical entity found in young men with endocrine disorders.
  • Histologically it resembles Leydig cell tumor.
  • We 1) reviewed the clinical features of testicular tumor of the adrenogenital syndrome and 2) determined if special histopathological features of the tumor and synaptophysin reactivity could distinguish testicular tumor of the adrenogenital syndrome from Leydig cell tumor.
  • MATERIALS AND METHODS: We reviewed the medical and pathological records for all patients with testicular tumor of the adrenogenital syndrome seen at our institution from 1978 to 2004.
  • These tumors were examined by histological and immunophenotypic methods for comparison to Leydig cell tumor.
  • RESULTS: A total of 14 males with an endocrine disorder had pathological evidence of testicular tumor of the adrenogenital syndrome.
  • These tumors were often bilateral (93% or 13 of 14 cases), associated with pain (92% or 12 of 13) and refractory to medical management with high dose exogenous steroids (93% or 13 of 14).
  • Testicular tumor of the adrenogenital syndrome was managed by tumor enucleation in 7 patients (54%) and by radical orchiectomy in 6 (46%).
  • Upon histological review features found to be more common to testicular tumor of the adrenogenital syndrome compared with Leydig cell tumor were nuclear pleiomorphism, low mitotic activity, extensive fibrosis, lymphoid aggregates, adipose metaplasia and prominent lipochrome pigment.
  • Synaptophysin (ICN, Costa Mesa, California) reactivity was strong in testicular tumor of the adrenogenital syndrome but rarely observed in Leydig cell tumor.
  • CONCLUSIONS: In our series medical treatment failed in patients with testicular tumor of the adrenogenital syndrome and conservative surgical therapy was possible in select individuals.
  • We identified special histopathological and immunophenotypic features, including synaptophysin staining, which distinguish testicular tumor of the adrenogenital syndrome from Leydig cell tumor.
  • [MeSH-major] Adrenogenital Syndrome / complications. Leydig Cell Tumor / pathology. Testicular Neoplasms / etiology. Testicular Neoplasms / pathology

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  • (PMID = 17222630.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. López PJ, Cadena Y, Paulos A, Angel L, Zubieta R: Unusual presentation of a Leydig Cell Tumor. Arch Esp Urol; 2010 May;63(4):303-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual presentation of a Leydig Cell Tumor.
  • SUMMARY: Leydig Cell Tumors (LCT) in children are very rare, with an incidence of 1-3% for all testicular tumors in children.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis

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  • (PMID = 20511687.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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69. Phillips N, Jequier AM: Early testicular cancer: a problem in an infertility clinic. Reprod Biomed Online; 2007 Nov;15(5):520-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On testicular ultrasound examination, the presence of a testicular tumour was suspected in nine men.
  • A malignant tumour (seminomata) was present in five of these seven men, representing a malignancy incidence of 0.7% (5/749).
  • In the two other men who underwent an orchidectomy, a benign Leydig cell tumour and an area of Sertoli cell-only were discovered, respectively.
  • A watch was kept on the apparent tumour sites in the remaining two men, revealing no change in ultrasonic appearance over a period of 2-12 months.
  • These data demonstrate that testicular tumours can present in an infertility clinic among men with normal as well as an abnormal semen analysis.

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  • (PMID = 18028743.001).
  • [ISSN] 1472-6483
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. Froehner M, Beuthien-Baumann B, Dittert DD, Schuler U, Wirth MP: Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor. Cancer Chemother Pharmacol; 2006 Nov;58(5):716-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor.
  • Imatinib is a tyrosine kinase inhibitor with activity in gastrointestinal stromal tumor and a variety of other solid and hematological malignancies.
  • Studies in vitro and in a mouse model suggested that the imatinib might also be active in malignant Leydig cell tumor.
  • We report on the--to our knowledge--first treatment experiment with imatinib in a patient with metastatic Leydig cell tumor.
  • Unfortunately, the tumor progressed during treatment.
  • [MeSH-major] Leydig Cell Tumor / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Testicular Neoplasms / drug therapy

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  • (PMID = 16450163.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Enzyme Inhibitors; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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71. Lee G, Lee JH, Lee WA: F-18 FDG PET/CT imaging of a Leydig cell tumor. Clin Nucl Med; 2010 Mar;35(3):202-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] F-18 FDG PET/CT imaging of a Leydig cell tumor.
  • We report the F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings of a patient with a testicular Leydig cell tumor.
  • The tumor was pathologically confirmed as a Leydig cell tumor.
  • [MeSH-major] Fluorodeoxyglucose F18. Leydig Cell Tumor / radiography. Leydig Cell Tumor / radionuclide imaging. Positron-Emission Tomography. Testicular Neoplasms / radiography. Testicular Neoplasms / radionuclide imaging. Tomography, X-Ray Computed

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  • (PMID = 20173460.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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72. Irizarry-Rovira AR, Lennox AM, Ramos-Vara JA: Granular cell tumor in the testis of a rabbit: cytologic, histologic, immunohistochemical, and electron microscopic characterization. Vet Pathol; 2008 Jan;45(1):73-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor in the testis of a rabbit: cytologic, histologic, immunohistochemical, and electron microscopic characterization.
  • Pathologic evaluation (exfoliative cytology, histopathology, immunohistochemistry, electron microscopy) indicated that the tumor was an intratesticular granular cell tumor.
  • Granular cell tumor has not been described in rabbits before and has not been described in the testes of animals or postnatal humans.
  • Granular cell tumor should be included as a differential diagnosis of testicular tumors, particularly Leydig cell tumor, because of potential histologic similarities.
  • [MeSH-major] Granular Cell Tumor / veterinary. Rabbits. Testicular Neoplasms / veterinary

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  • (PMID = 18192581.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Carvajal-Carmona LG, Alam NA, Pollard PJ, Jones AM, Barclay E, Wortham N, Pignatelli M, Freeman A, Pomplun S, Ellis I, Poulsom R, El-Bahrawy MA, Berney DM, Tomlinson IP: Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations. J Clin Endocrinol Metab; 2006 Aug;91(8):3071-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations.
  • CONTEXT: Leydig cell tumors (LCTs) are the most common non-germ-cell neoplasms of the testis.
  • We identified an LCT in an affected individual from a kindred with hereditary leiomyomatosis and renal cell cancer (HLRCC) and a germline fumarate hydratase (FH) mutation (N64T).
  • RESULTS: No mutations were found in GNAS, and one tumor had a LHCGR somatic substitution.
  • Immunohistochemical and in situ hybridization analyses demonstrated activation of the hypoxia/angiogenesis pathway not only in the tumors belonging to the FH mutation carriers but also in several other mutation-negative LCTs.
  • CONCLUSIONS: Our study shows that some LCTs are caused by FH mutations and represents one of the first reports of germline mutations in any type of adult testicular tumor.
  • [MeSH-major] Fumarate Hydratase / genetics. Genetic Predisposition to Disease. Germ-Line Mutation. Leydig Cell Tumor / genetics. Testicular Neoplasms / genetics

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  • (PMID = 16757530.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Receptors, LH; 0 / Vascular Endothelial Growth Factor A; EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs; EC 4.2.1.2 / Fumarate Hydratase
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74. Alam K, Maheshwari V, Rashid S, Bhargava S: Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. Indian J Pathol Microbiol; 2009 Jan-Mar;52(1):97-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report.
  • Sertoli leydig cell tumors also known as arrhenoblastoma, are a rare member of the sex cord-stromal tumor group of ovarian and testicular cancers, comprising less than 1% of all ovarian tumors, which occur in young adults and are almost always unilateral.
  • We hereby report a case of a 17-year-old female presenting with a short history of irregular menses and an abdominal lump, which was histologically proven to be a bilateral sertoli leydig cell tumor of the ovary, an exceptionally rare entity in itself.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovary / pathology. Sertoli-Leydig Cell Tumor / diagnosis. Sertoli-Leydig Cell Tumor / pathology

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  • (PMID = 19136796.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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75. Verdorfer I, Horst D, Höllrigl A, Susani M, Hartmann A, Rogatsch H, Mikuz G: Leydig cell tumors of the testis: a molecular-cytogenetic study based on a large series of patients. Oncol Rep; 2007 Mar;17(3):585-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leydig cell tumors of the testis: a molecular-cytogenetic study based on a large series of patients.
  • The genetic features of the uncommon Leydig cell tumors (LCT) are largely unknown.
  • Consequently, it is of great importance to elucidate the pathogenesis of testicular germ cell tumors by cytogenetic and molecular biological investigations.
  • The purpose of the present study was the examination of cytogenetic features of these tumors in a large series of LCT.
  • In most of the studied cases, the aberrant cell population was additionally defined by interphase fluorescence in situ hybridization (I-FISH).
  • [MeSH-major] DNA, Neoplasm / genetics. Leydig Cell Tumor / genetics. Testicular Neoplasms / genetics

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  • (PMID = 17273737.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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76. Shirley S, Devi VS, Krishnamurthy R, Nabhi MV, Majhi U, Selvaluxmy G: Endometrial adenocarcinoma involving both horns of a bicornuate uterus. J Cancer Res Ther; 2010 Jul-Sep;6(3):304-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Incidentally, the left ovary revealed a well differentiated sertoli leydig cell tumor.
  • Its simultaneous occurrence with an ovarian sertoli leydig cell tumor has not been reported in English literature so far.

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  • (PMID = 21119258.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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77. Mukherjee S, Diver M, Weston PJ: Non islet cell tumor hypoglycaemia in a metastatic Leydig cell tumor. Acta Oncol; 2005;44(7):761-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non islet cell tumor hypoglycaemia in a metastatic Leydig cell tumor.
  • Non islet cell tumour hypoglycaemia (NICTH) is a rare cause of hypoglycaemia associated with malignancy and can be considered as a paraneoplastic syndrome.
  • Treatment options are either surgical removal of the tumour, administration of growth hormone, glucocorticoids or combination of treatments.
  • A case of metastatic Leydig cell tumour causing NICTH has been discussed and the mechanism of NICTH hypoglycaemia and the treatment is outlined.
  • [MeSH-major] Glucocorticoids / therapeutic use. Hypoglycemia / etiology. Leydig Cell Tumor / secondary. Pancreatic Neoplasms / drug therapy. Testicular Neoplasms / secondary

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  • (PMID = 16227169.001).
  • [ISSN] 0284-186X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / C-Peptide; 0 / Glucocorticoids; 0 / Insulin; 67763-96-6 / Insulin-Like Growth Factor I; 67763-97-7 / Insulin-Like Growth Factor II
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78. Bertola G, Giambona S, Balza G, Sironi C, Colombo E, Santangelo M, Di Nuovo F: [An uncommon cause of gynecomastia: testicular Leydig cell tumor. Hormonal profile before and after orchiectomy]. Recenti Prog Med; 2006 Feb;97(2):85-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An uncommon cause of gynecomastia: testicular Leydig cell tumor. Hormonal profile before and after orchiectomy].
  • Leydig cell tumors (LTC) are uncommon neoplasms arising from gonadal stroma that account for 1-3% of all testicular tumors.
  • [MeSH-major] Gynecomastia / etiology. Leydig Cell Tumor / complications. Leydig Cell Tumor / diagnosis. Orchiectomy. Testicular Neoplasms / complications. Testicular Neoplasms / diagnosis

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  • (PMID = 16671273.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol
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79. Pastor Navarro H, Donate Moreno MJ, Carrión López P, Pastor Guzmán JM, Segura Martín M, Lorido Cortés MM, Cañamares Pabolaza L, Ruíz Mondéjar R, Salinas Sánchez AS, Virseda Rodríguez JA: [Current status of the diagnosis and treatment of Leydig cell testicular tumor. Report of two cases]. Arch Esp Urol; 2008 Jan-Feb;61(1):27-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Current status of the diagnosis and treatment of Leydig cell testicular tumor. Report of two cases].
  • [Transliterated title] Estado actual del diagnóstico y tratamiento del tumor testicular de células de Leydig. Aportación de dos casos.
  • OBJECTIVES: To review the current diagnosis and treatment of Leydig cell testicular tumors, with special attention to conservative treatment.
  • METHODS: We report two cases of Leydig cell tumor in young adults, diagnosed two years after the appearance of bilateral gynecomastia as first clinical symptom.
  • CONCLUSIONS: Around 10% of the cases, and only in adult patients, these tumors may be malignant, being radical orchyectomy the treatment of choice, although conservative surgery may be performed.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Leydig Cell Tumor / surgery. Testicular Neoplasms / diagnosis. Testicular Neoplasms / surgery

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  • (PMID = 18405025.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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80. Colpi GM, Carmignani L, Nerva F, Guido P, Gadda F, Castiglioni F: Testicular-sparing microsurgery for suspected testicular masses. BJU Int; 2005 Jul;96(1):67-9
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  • Histology revealed one case each of seminoma, Leydig-cell tumour, Leydig cell hyperplasia, atrophy, normality in the incidental forms, and complicated cysts of the albuginea.
  • CONCLUSIONS: The increasingly frequent detection of benign testicular lesions, particularly in infertile men, calls for a surgical approach that must be as conservative as possible for the testicular parenchyma.
  • [MeSH-major] Infertility, Male / surgery. Leydig Cell Tumor / surgery. Seminoma / surgery. Testicular Neoplasms / surgery. Testis / surgery

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  • (PMID = 15963123.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Goodman JE, Gaylor D, Beyer LA, Rhomberg LR, Beck BD: Effects of MTBE on the reported incidence of Leydig cell tumors in Sprague-Dawley rats: range of possible Poly-3 results. Regul Toxicol Pharmacol; 2008 Apr;50(3):273-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of MTBE on the reported incidence of Leydig cell tumors in Sprague-Dawley rats: range of possible Poly-3 results.
  • An increased Leydig cell tumor (LCT) incidence has been reported in a study of Sprague-Dawley (SD) rats exposed via gavage to 1000 (but not 250)mg/kgday MTBE; it is unclear, however, if this finding was indeed dose-related or due to the statistical analyses not having adequately accounted for the increased survival rate in the high-dose animals and/or for multiple statistical comparisons.
  • To address this question, we conducted Hoel-Walburg and Poly-3 analyses, using p-values of 0.01 for pair-wise comparisons and 0.005 for trend tests of common tumors.
  • This led us to conduct separate Poly-3 analyses for the most extreme scenarios of survival age and tumor incidence to provide an illustrative example of approaches for analyzing the impact of survival rates on tumor findings in the absence of animal-specific survival data.
  • [MeSH-major] Leydig Cell Tumor / chemically induced. Leydig Cell Tumor / epidemiology. Methyl Ethers / toxicity. Models, Statistical. Survival Analysis. Testicular Neoplasms / chemically induced. Testicular Neoplasms / epidemiology

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  • [CommentIn] Regul Toxicol Pharmacol. 2008 Apr;50(3):428-9 [17905498.001]
  • (PMID = 18241965.001).
  • [ISSN] 0273-2300
  • [Journal-full-title] Regulatory toxicology and pharmacology : RTP
  • [ISO-abbreviation] Regul. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Methyl Ethers; 29I4YB3S89 / methyl tert-butyl ether
  • [Number-of-references] 38
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82. Sirianni R, Chimento A, De Luca A, Zolea F, Carpino A, Rago V, Maggiolini M, Andò S, Pezzi V: Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells. J Biol Chem; 2009 Oct 16;284(42):28905-16
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  • [Title] Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.
  • Our recent studies have revealed that estrogens stimulate an autocrine mechanism determining Leydig tumor cell proliferation.
  • Although we have shown that increased SF-1 expression depends mainly on higher local insulin-like growth factor I production, the mechanisms and factors determining increased CREB activation in Leydig tumor cells are not completely understood.
  • In this study, we investigated the role of cyclooxygenase-2 (COX-2) in CREB dependent-aromatase expression in Leydig tumor cells.
  • We found that COX-2 is expressed in rat and human Leydigiomas as well as in the rat Leydig tumor cell line R2C, but not in normal testis.
  • The reduction in aromatase activity was responsible for a drop in estrogen production and subsequent reduction in cyclin E expression resulting in a decrease in tumor Leydig cell proliferation.
  • Furthermore, COX-2 silencing caused a significant decrease in CREB phosphorylation, aromatase expression, and R2C cell proliferation.
  • These novel findings clarify the mechanisms involved in the growth of Leydig cell tumors and should be taken into account in determining new therapeutic approaches.
  • [MeSH-major] Aromatase / metabolism. Cell Proliferation / drug effects. Cyclooxygenase 2 / chemistry. Cyclooxygenase Inhibitors / pharmacology. Gene Expression Regulation, Enzymologic
  • [MeSH-minor] Adult. Animals. Cell Line, Tumor. Cyclic AMP Response Element-Binding Protein / chemistry. Humans. Insulin-Like Growth Factor I / metabolism. Leydig Cells. Male. Phosphorylation. Rats. Rats, Inbred F344

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  • (PMID = 19679653.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP Response Element-Binding Protein; 0 / Cyclooxygenase Inhibitors; 67763-96-6 / Insulin-Like Growth Factor I; EC 1.14.14.1 / Aromatase; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ PMC2781436
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83. Carmignani L, Morabito A, Gadda F, Bozzini G, Rocco F, Colpi GM: Prognostic parameters in adult impalpable ultrasonographic lesions of the testicle. J Urol; 2005 Sep;174(3):1035-8
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  • MATERIALS AND METHODS: We performed a bibliographic search on PubMed, MEDLINE, EMBASE online databases from 1990 to May 2004 using search words such as sonographic lesions of the testicle, impalpable tumors of the testicle and impalpable testicular lesions.
  • Six articles were found that presented a description of the histological characteristics, patient age, lesion dimensions, presence of cryptorchidism and association with tumors in other parts of the body.
  • Histologically 15 of the lesions were Leydig cell tumors (31%), 12 (25%) seminomas, 7 (14.5%) nonseminomatous germ cell tumors, 2 (4.5%) Sertoli cell tumors, 12 (25%) benign forms (fibrosis, infarct, lipoma, mesothelial hyperplasia, adenomatoid tumor).
  • Dimension was particularly related to germ cell tumors (for dimensions between 16 and 32 mm relative risk ratio [RRR] = 13.97, p=0.0449).
  • Infertility proved significant in defining stromal tumors (RRR = 9,681, p=0.022) CONCLUSIONS: Although with the limits of a retrospective study consisting in an analysis of individual data, interesting correlations between malignant pathologies and the initial characteristics of impalpable sonographic lesions were revealed.
  • In particular an interesting correlation was found between the dimensions of the lesion and the malignant pathology and between Leydig cell tumor and infertility.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Follow-Up Studies. Humans. Infertility, Male / mortality. Infertility, Male / pathology. Infertility, Male / ultrasonography. Logistic Models. Male. Mathematical Computing. Middle Aged. Multivariate Analysis. Neoplasms, Germ Cell and Embryonal / mortality. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / ultrasonography. Prognosis. Retrospective Studies. Risk. Statistics as Topic. Survival Rate. Task Performance and Analysis

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  • (PMID = 16094042.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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84. Sirianni R, Chimento A, Malivindi R, Mazzitelli I, Andò S, Pezzi V: Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation. Cancer Res; 2007 Sep 1;67(17):8368-77
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  • [Title] Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation.
  • The aim of this study was to investigate the role of estrogens in Leydig cell tumor proliferation.
  • We used R2C rat Leydig tumor cells and testicular samples from Fischer rats with a developed Leydig tumor.
  • Treatment with exogenous 17beta-estradiol (E(2)) induced proliferation of R2C cells and up-regulation of cell cycle regulators cyclin D1 and cyclin E, the expression of which was blocked by addition of antiestrogens.
  • These observations led us to hypothesize an E(2)/ERalpha-dependent mechanism for Leydig cell tumor proliferation.
  • In determining the molecular mechanism responsible for aromatase overexpression, we found that total and phosphorylated levels of transcription factors cyclic AMP-responsive element binding protein and steroidogenic factor 1 (SF-1) were higher in tumor samples.
  • Moreover, we found that tumor Leydig cells produce high levels of insulin-like growth factor I (IGF-I), which increased aromatase mRNA, protein, and activity as a consequence of increased total and phosphorylated SF-1 levels.
  • The same inhibitors also inhibited aromatase expression and activity and, consequently, R2C cell proliferation.
  • We can conclude that one of the molecular mechanisms determining Leydig cell tumorigenesis is an excessive estrogen production that stimulates a short autocrine loop determining cell proliferation.
  • In addition, cell-produced IGF-I amplifies estrogen signaling through an SF-1-dependent up-regulation of aromatase expression.
  • The identification of this molecular mechanism will be helpful in defining new therapeutic approaches for Leydig cell tumors.
  • [MeSH-major] Aromatase / genetics. Cell Proliferation / drug effects. Estrogens / pharmacology. Homeodomain Proteins / physiology. Insulin-Like Growth Factor I / physiology. Leydig Cell Tumor / pathology. Receptors, Cytoplasmic and Nuclear / physiology. Testicular Neoplasms / pathology. Transcription Factors / physiology

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  • (PMID = 17804753.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; 0 / Homeodomain Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Steroidogenic Factor 1; 0 / Transcription Factors; 0 / steroidogenic factor 1, mouse; 0 / steroidogenic factor 1, rat; 67763-96-6 / Insulin-Like Growth Factor I; EC 1.14.14.1 / Aromatase
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85. Antón L, Pérez-Etchepare E, Soriano D, Gómez M, Barrientos G, Tracchia R: [Testicular tumors: wide spectrum in our short casuistics]. Cir Pediatr; 2010 Oct;23(4):222-4
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  • [Title] [Testicular tumors: wide spectrum in our short casuistics].
  • Testicular tumors occur in 0.5 to 2 per 100,000 children.
  • They are 1-2% of all solid tumors before puberty.
  • The pathology determines the specific cell.
  • We report seven cases, three germ cell tumors: a Yolk sac tumor in a child of 18 months and two mature teratomas in children between 2 and 11 years presenting as a painless testicular mass without other symptoms.
  • Three tumors estrumales: one derived from Leydig cells and two of the granulosa cells, a palpable testicular mass was added precocious puberty in stage II-III of Tanner in the first, second gynecomastia in Tanner stage III and the third only with testicular mass.
  • Testis-sparing surgery in Leydig cell tumor and resection of the paratesticular mass was performed through scrotal.
  • The Yolk sac tumor requiring chemotherapy with good outcome.
  • Historically prepubertal testicular tumors have been treated in adults.
  • Many are benign and can be treated with preservation of the testis.
  • Localized malignant tumors can be treated by orchiectomy.

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  • (PMID = 21520554.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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86. Bohlmann MK, Rabe T, Sinn HP, Strowitzki T, Von Wolff M: Intraoperative venous blood sampling to localize a small androgen-producing ovarian tumor. Gynecol Endocrinol; 2005 Sep;21(3):138-41
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  • [Title] Intraoperative venous blood sampling to localize a small androgen-producing ovarian tumor.
  • BACKGROUND: Among other causes of virilization, ovarian tumors can be the cause of excessive androgen production.
  • We report the case of a Leydig cell tumor of the ovary where diagnostic attempts to localize the source of hyperandrogenism preoperatively failed owing to relatively small tumor size.
  • Intraoperative selective blood sampling of the ovarian veins and palpation gave evidence of a right ovarian tumor, which was then removed.
  • Histological examination revealed the presence of a pure Leydig cell tumor.
  • CONCLUSION: Exploratory laparotomy with intraoperative selective blood sampling of the ovarian veins might be a useful approach in patients without accurate preoperative localization of androgen-producing tumors of the ovaries.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 16335905.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Androgens; 9002-60-2 / Adrenocorticotropic Hormone
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87. Carmignani L, Gadda F, Gazzano G, Ragni G, Paffoni A, Rocco F, Colpi GM: Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. Hum Reprod; 2007 Apr;22(4):1068-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study is to evaluate the feasibility of testicular sperm extraction (TESE) in a cancerous testicle during orchiectomy for testicular neoplasm.
  • In two patients, a Leydig cell tumour was found (one patient underwent orchiectomy for large nodule size).


88. Tucker AR, Smith JR: Prostatic squamous metaplasia in a cat with interstitial cell neoplasia in a retained testis. Vet Pathol; 2008 Nov;45(6):905-9
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  • [Title] Prostatic squamous metaplasia in a cat with interstitial cell neoplasia in a retained testis.
  • Histopathologic diagnosis was retained testis with a well-differentiated interstitial cell tumor, a poorly differentiated interstitial cell tumor, and marked squamous metaplasia of the prostatic epithelium with suppurative prostatitis.
  • Neoplastic interstitial cells were immunoreactive for Melan A, consistent with reports of Melan A expression in steroid hormone-producing tissue.
  • [MeSH-major] Cat Diseases / pathology. Cryptorchidism / veterinary. Leydig Cell Tumor / veterinary. Prostate / pathology

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  • (PMID = 18984794.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Treiyer A, Blanc G, Stark E, Haben B, Treiyer E, Steffens J: Prepubertal testicular tumors: frequently overlooked. J Pediatr Urol; 2007 Dec;3(6):480-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prepubertal testicular tumors: frequently overlooked.
  • OBJECTIVE: Prepubertal testicular tumors are fundamentally distinct from their adult counterparts.
  • MATERIAL AND METHODS: A retrospective review was performed of all testicular tumors diagnosed between 1996 and 2006 in males younger than 14 years.
  • RESULTS: Of 15 primary testicular tumors, eight (53%) were germ-cell tumors (three teratomas, two yolk sac tumors, one seminoma, one embryonic carcinoma and one choriocarcinoma), four (27%) tumor-like lesions (epidermoid cysts), two (13%) gonadal stromal tumors (a Leydig and a Sertoli cell tumor), and one (7%) gonadoblastoma with gonadal dysgenesis.
  • All boys were presented with a painless scrotal mass and four (27%) of them with elevated tumor markers.
  • At a mean 4-year follow-up no patient has presented with recurrent tumor in the residual or contralateral testicle.
  • Postoperative physical examination and scrotal ultrasound were obtained in 14 patients at a median follow-up of 48.2 months, and there was no evidence of tumor progression.
  • CONCLUSIONS: Benign teratoma and epidermoid cysts were the most common prepubertal testicular tumors.
  • Any suspicion of a testicular tumor warrants an inguinal approach to prevent scrotal violation of the tumor.
  • Our limited experience with testis-sparing procedures supports the current trends that organ-confined surgery should be performed for benign lesions such as teratoma, Leydig cell tumor and epidermoid cysts based on frozen biopsy findings.

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  • (PMID = 18947799.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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90. Canda AE, Atmaca AF, Ozdemir AT, Akbulut Z, Balbay MD: Testis sparing surgery for sequential bilateral testicular tumors. Can J Urol; 2009 Jun;16(3):4677-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testis sparing surgery for sequential bilateral testicular tumors.
  • OBJECTIVE: We present our experience in performing testis sparing surgery (TSS) to treat sequential bilateral testicular tumors.
  • MATERIAL AND METHODS: We performed TSS on two patients with bilateral sequential testicular tumors.
  • The patients were diagnosed with secondary testicular tumors in the contralateral testes on follow up.
  • Pathologic evaluation of the removed tumors revealed immature teratoma and Leydig cell tumor.

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  • (PMID = 19497179.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 11
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91. Mirzaei MR, Rezvanian H, Siavash M, Parham M, Mahzouni P: A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
  • Testicular adrenal rest tumour (TART) due to CYP11B1 deficiency is a very rare clinical finding.
  • The most important differential diagnosis of his latter presentation is Leydig cell tumour (LCT).
  • Conversely, high titres of tumour markers and presence of Reinke crystalloids are supportive of a diagnosis of LCT.

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  • [Cites] AJR Am J Roentgenol. 1999 May;172(5):1235-8 [10227495.001]
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  • (PMID = 21686875.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028312
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92. Jain SH, Sadow PM, Nosé V, Dluhy RG: A patient with ectopic cortisol production derived from malignant testicular masses. Nat Clin Pract Endocrinol Metab; 2008 Dec;4(12):695-700
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  • Nevertheless, the possibility of a malignant Leydig cell tumor with ectopic cortisol production could not be excluded.
  • Despite initial success with this regimen, the patient died as a result of tumor progression and complications of poorly controlled hypercortisolism.
  • [MeSH-major] Adrenal Rest Tumor / complications. Cushing Syndrome / diagnosis. Cushing Syndrome / drug therapy. Hydrocortisone / blood. Testicular Neoplasms / complications

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  • (PMID = 18941436.001).
  • [ISSN] 1745-8374
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 78E4J5IB5J / Mitotane; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone; ZS9KD92H6V / Metyrapone
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93. Wang W, Gong ZH, Dai YT: [Value of ultrasonography in the diagnosis and differential diagnosis of testicular tumor]. Zhonghua Nan Ke Xue; 2007 May;13(5):424-7
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  • [Title] [Value of ultrasonography in the diagnosis and differential diagnosis of testicular tumor].
  • OBJECTIVE: To evaluate ultrasonography in the diagnosis and differential diagnosis of testicular tumor.
  • RESULTS: Of the total number, 50 cases were testicular hematoma, 13 testicular cyst, 26 testicular inflammatory node, 25 testicular tuberculosis and 58 testicular tumor.
  • Among 59 testicular tumor cases, 50 were germ cell tumor (including 41 cases of seminoma and 9 cases of nonseminoma germ cell tumor), 6 were non-germ cell tumor and 3 were secondary tumor.
  • The sonographic features of typical seminoma, teratomas, epidemic cyst, interstitial cell tumor and malignant lymphoma were obvious.
  • CONCLUSION: Ultrasonography, contributive to the preliminary diagnosis and differential diagnosis of testicular tumor and capable of evidence for further treatment, can be the first choice in medical imaging for the diagnosis of testicular tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / ultrasonography. Hematoma / ultrasonography. Humans. Male. Middle Aged. Retrospective Studies. Teratoma / ultrasonography. Testicular Diseases / surgery

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  • (PMID = 17569259.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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94. Shanbhogue AK, Shanbhogue DK, Prasad SR, Surabhi VR, Fasih N, Menias CO: Clinical syndromes associated with ovarian neoplasms: a comprehensive review. Radiographics; 2010 Jul-Aug;30(4):903-19
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  • Sex cord-stromal tumors, the most common functional ovarian neoplasms, are associated with either hyperestrogenism (as in granulosa cell tumor and thecoma) or hyperandrogenism (as in Sertoli-Leydig cell tumor and Leydig cell tumor).
  • Other, less common ovarian neoplasms that may have endocrine or nonendocrine syndromic manifestations include germ cell tumors associated with the excessive production of human chorionic gonadotropin (eg, choriocarcinoma, dysgerminoma), monodermal teratomas (eg, carcinoid tumor, struma ovarii) associated with carcinoid syndrome and hyperthyroidism, and primary epithelial ovarian cancers associated with paraneoplastic syndromes.

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  • (PMID = 20631359.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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95. Cvijovic G, Yamashita SA, Micic D, Kendereski A, Sumarac-Dumanovic M, Zoric S, Popovic V: Low leptin level in an obese hyperandrogenic woman--potential marker for androgen-secreting tumor. Gynecol Endocrinol; 2007 Feb;23(2):112-6
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  • [Title] Low leptin level in an obese hyperandrogenic woman--potential marker for androgen-secreting tumor.
  • Hyperandrogenism in postmenopausal women is due to ovarian hyperthecosis or an androgen-secreting ovarian/adrenal tumor.
  • Making the correct diagnosis might be complicated due to the possible existence of an adrenal neoplasm secreting testosterone only, ectopic ovarian tissue or ectopic luteinizing hormone/human chorionic gonadotropin receptors in the adrenals, as well as the relatively low sensitivity of imaging techniques (computed tomography, magnetic resonance imaging) and vein catheterization for this type of pathology.
  • We present the case of an obese postmenopausal woman with metabolic syndrome, hyperandrogenism (high testosterone levels, suppressed gonadotropins), adrenal macronodular hyperplasia and Leydig-cell ovarian tumor.
  • Then, bilateral oophorectomy with hysterectomy was performed and a small Leydig-cell tumor was found in the left ovary.
  • In conclusion, we speculate that low leptin levels in obese hyperandrogenic women might be a marker for androgen-secreting tumors.
  • [MeSH-major] Alopecia / etiology. Hirsutism / etiology. Hyperandrogenism / etiology. Leydig Cell Tumor / metabolism. Ovarian Neoplasms / metabolism

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  • (PMID = 17454162.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin
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96. Papaioannou N, Psalla D, Zavlaris M, Loukopoulos P, Tziris N, Vlemmas I: Immunohistochemical expression of dog TERT in canine testicular tumours in relation to PCNA, ki67 and p53 expression. Vet Res Commun; 2009 Dec;33(8):905-19
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  • [Title] Immunohistochemical expression of dog TERT in canine testicular tumours in relation to PCNA, ki67 and p53 expression.
  • The objective of the study was to determine the immunohistochemical expression of canine TERT in canine testicular tumours comparing two different antibodies for TERT, and to correlate them with well established markers specific to dividing cells such as PCNA and ki67, and with expression of the p53 tumour suppressor gene.
  • The study included 36 cases of canine testicular tumours, which were categorized as 12 Sertoli Cell Tumours (SCT), 20 seminomas, 3 interstitial cell tumours and 1 mixed germ cell-sex cord stromal tumour (MT).
  • Immunodetection of RCK-hTERT was observed in 31% of tumours examined (6/20 Seminomas, 4/12 SCT, 1/3 interstitial cell tumour and 0/1 mixed germ cell-sex cord stromal tumour), while the NCL-hTERT in 67% of them (15/20 Seminomas, 6/12 SCT, 3/3 interstitial cell tumour and 0/1 ΜΤ).
  • Regarding ki67, 3 SCT, 12 seminomas and all interstitial cell tumours showed clear immunoreaction. p53 immunoreactivity was detected in 6 SCT, 15 seminomas and all interstitial cell tumours.
  • The immunohistochemical expression of both TERT antibodies are discussed and compared in order to clarify their potential usefulness in canine testicular malignancies in relation to the expression of well known cell cycle markers.
  • Instead of that ki67 and p53 could be used for predicting aggressiveness in this group of tumours.
  • [MeSH-major] Dog Diseases / metabolism. Ki-67 Antigen / metabolism. Proliferating Cell Nuclear Antigen / metabolism. Telomerase / metabolism. Testicular Neoplasms / veterinary. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Animals. Dogs. Gene Expression Regulation, Neoplastic. Leydig Cell Tumor / metabolism. Leydig Cell Tumor / veterinary. Male. Seminoma / metabolism. Seminoma / veterinary. Sertoli Cell Tumor / metabolism. Sertoli Cell Tumor / veterinary. Testis / metabolism. Testis / pathology

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  • (PMID = 19655265.001).
  • [ISSN] 1573-7446
  • [Journal-full-title] Veterinary research communications
  • [ISO-abbreviation] Vet. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53; EC 2.7.7.49 / Telomerase
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97. Bacchetta J, Droz JP: [Practical use of o,p'DDD in adrenocortical carcinoma]. Bull Cancer; 2005 Mar;92(3):273-9
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  • Adrenocortical carcinoma (AC) is a rare tumor of poor prognosis.
  • Five patients (four with AC and one with a metastatic Leydig cell tumor of the testis) were treated by Lysodren.

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  • (PMID = 15820922.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 78E4J5IB5J / Mitotane
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98. Kawakami E, Hirano T, Hori T, Tsutsui T: Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis. J Vet Med Sci; 2007 Dec;69(12):1259-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
  • The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively.
  • The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-alpha concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis.
  • The low SOD activity in the cryptorchid testis, low blood plasma INH-alpha concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.

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  • (PMID = 18176022.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / HSP70 Heat-Shock Proteins; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 1.15.1.1 / Superoxide Dismutase
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99. Bry-Gauillard H, Meduri G, Abirached F, Constancis E, Brailly S, Chanson P, Young J: Primary amenorrhea revealing an occult progesterone-secreting ovarian tumor. Fertil Steril; 2008 Oct;90(4):1198.e1-5
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  • [Title] Primary amenorrhea revealing an occult progesterone-secreting ovarian tumor.
  • OBJECTIVE: To describe a patient with primary amenorrhea revealing an occult progesterone-secreting ovarian tumor.
  • MAIN OUTCOME MEASURE(S): Discovery of an occult progesterone-secreting ovarian tumor.
  • After long-term follow-up, a right ovarian tumor became apparent and was surgically removed.
  • Pathologic and immunohistochemical analysis showed a Leydig cell tumor expressing cytochrome P450 side-chain cleavage and 3ss-hydroxysteroïd dehydrogenase enzymes, which are involved in progesterone biosynthesis, whereas P45017alpha-hydroxylase was not expressed, explaining the absence of hyperandrogenemia.
  • CONCLUSION: This is the first case of isolated progesterone secretion by an occult ovarian Leydig cell tumor and a novel etiology of primary amenorrhea.

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  • (PMID = 18304537.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4G7DS2Q64Y / Progesterone
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100. Kaneko T, Sasaki S, Umemoto Y, Kojima Y, Ikeuchi T, Kohri K: Simulated conditions of microgravity increases progesterone production in I-10 cells of Leydig tumor cell line. Int J Urol; 2008 Mar;15(3):245-50
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  • [Title] Simulated conditions of microgravity increases progesterone production in I-10 cells of Leydig tumor cell line.
  • The present study examines the effects of the microgravity (muG) environment on steroidogenesis of Leydig cells.
  • Western blots of the enzyme, 3betahydroxy dehydrogenase (HSD) as well as of the transcription factors, Ad4bp/SF-1 and DAX-1, the amount of adenosine3',5'-cyclic monophosphate (cAMP) and cell morphology were investigated.
  • [MeSH-major] Leydig Cell Tumor / pathology. Leydig Cells / metabolism. Progesterone / biosynthesis. Weightlessness Simulation
  • [MeSH-minor] Cell Line, Tumor. Humans. Male

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  • (PMID = 18304221.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 4G7DS2Q64Y / Progesterone
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