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1. Matsuo T, Hayashi Y, Ujifuku K, Baba S, Kamada K, Hayashi N, Nagata I: [Radiation injury after stereotactic irradiaton: especially long-term follow-up benign of targets]. No Shinkei Geka; 2009 Dec;37(12):1201-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Radiation injury after stereotactic irradiaton: especially long-term follow-up benign of targets].
  • OBJECTIVE: To analyses the result of linac radiosurgery (LRS) for the treatment of intracranial benign lesions and to assess possible factors related to complications.
  • Imaging changes were seen mostly in cases with tumor volume greater than 5 cc.
  • [MeSH-major] Intracranial Arteriovenous Malformations / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 19999552.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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2. Nur S, Chuang L, Ramaswamy G: Primary extracranial meningioma of the pelvis: a light microscopic, immunohistochemical, and ultrastructural study. Gynecol Oncol; 2006 Nov;103(2):745-8
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  • The histology of the resected tumor revealed sheets of bland epithelioid cells arranged in prominent whorls with psammoma bodies typical of meningothelial meningioma.
  • By electron microscopy, the tumor cells expressed desmosomes and abundant intermediate filaments.
  • Its benign appearance and 4-year disease-free survival without clinical or radiological evidence of intracranial disease favors the pelvis as the primary site.
  • [MeSH-major] Meningioma / metabolism. Meningioma / ultrastructure. Pelvic Neoplasms / metabolism. Pelvic Neoplasms / ultrastructure

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  • (PMID = 16904168.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Kouklakis G, Babali A, Gatopoulou A, Lirantzopoulos N, Efremidou E, Vathikolias K: Asymptomatic brain finding results on MRI in a patient with Crohn's disease: a case report. J Gastrointestin Liver Dis; 2009 Dec;18(4):479-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the case of a 39-year old man with Crohn's disease and an intracranial benign primary tumor, detected on MRI scan.
  • [MeSH-major] Brain / pathology. Crohn Disease / complications. Incidental Findings. Magnetic Resonance Imaging. Meningeal Neoplasms / etiology. Meningioma / pathology

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  • (PMID = 20076823.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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4. Hodges JM, McDevitt AS, El-Sayed Ali AI, Sebelik ME: Juvenile nasopharyngeal angiofibroma: current treatment modalities and future considerations. Indian J Otolaryngol Head Neck Surg; 2010 Sep;62(3):236-47
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  • Juvenile angiofibroma (JNA) is a relatively uncommon, highly vascular and benign tumor that presents most commonly in adolescent males.
  • However, controversy arises regarding the best treatment when a patient presents with more locally advanced disease involving widespread cranial-based extension or intracranial involvement which may necessitate a combination of treatment modalities including surgery and postoperative radiation.With the advancement of endoscopic surgery, there have been a number of cases reporting the value of its use.

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  • (PMID = 23120720.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450247
  • [Keywords] NOTNLM ; Angiofibroma / Cyberknife / Embolization / Endoscopic surgery / IMRT / Image guided robotic radiotherapy / Skull base / Vascular tumor
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5. Nagulić M, Tukić L, Ilić S, Marković M: [Intracranial menigioma manifested after delivery in a patient with Hodgkin's disease]. Vojnosanit Pregl; 2006 Mar;63(3):305-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intracranial menigioma manifested after delivery in a patient with Hodgkin's disease].
  • BACKGROUND: Intracranial meningioma is rerely reported in the patients treated for Hodgkin's disease (HD), known to mainly occur in the area of radiation therapy.
  • CASE REPORT: A 26-year-old woman with HD, and intracranial meningioma following the delivery, was presented.
  • Three years prior the surgery for intracranial tumor, the patient had been started to be treated for HD of neoplasm stage I (NS I) type, by the use of the standard (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) BEA-COPP protocol.
  • Two days following the normal delivery, during the acute disorder of the consciousness, intracranial tumor was found.
  • CONCLUSION: there were no reliable signs of the use of an intensive hemotherapy in the reported case (alkylating cytostatics and topoisomerases inhibitors) which might have caused the proliferation of a benign solid tumor.
  • On the basis of the significant psychic disorders before the pregnancy, as well as upon the size of the operated on tumor, we concluded that the occurrence of intracranial meningioma could be regarded the parallel neoplastic disease or the second primary tumor.
  • [MeSH-major] Hodgkin Disease. Meningeal Neoplasms. Meningioma. Pregnancy Complications, Neoplastic
  • [MeSH-minor] Adult. Female. Humans. Neoplasms, Second Primary / diagnosis. Pregnancy


6. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Primary neoplasms of the external ear canal are rare, and 5% of these tumors are of glandular origin.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • These tumors are very rare and usually have a benign course.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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7. Zhao H, Li X, Lv Q, Yuan Y, Yu H: A large dumbbell glossopharyngeal schwannoma involving the vagus nerve: a case report and review of the literature. J Med Case Rep; 2008;2:334
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  • INTRODUCTION: Schwannoma arising from the glossopharyngeal nerve is a rare intracranial tumor.
  • A favorable option of approach and appropriate planning of surgical strategy should be the goal of operation for this benign tumor.

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  • (PMID = 18954436.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2584006
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8. Waseem M, Atkuri L, Laureta E: A febrile child with seizure and hemiparesis. Pediatr Emerg Care; 2006 Nov;22(11):718-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although most febrile seizures are simple and benign, these seizures can infrequently create a diagnostic dilemma.
  • The diagnosis of cerebral venous thrombosis is challenging to emergency physicians because it can mimic the presentation of many other disorders, including ischemic and hemorrhagic stroke, tumor, and abscess.
  • The patients may be presented with signs of increased intracranial pressure or focal neurological deficits.
  • [MeSH-major] Paresis / etiology. Seizures, Febrile / etiology. Sinus Thrombosis, Intracranial / complications

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  • (PMID = 17110863.001).
  • [ISSN] 1535-1815
  • [Journal-full-title] Pediatric emergency care
  • [ISO-abbreviation] Pediatr Emerg Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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9. Georgiadis P, Cavouras D, Kalatzis I, Glotsos D, Athanasiadis E, Kostopoulos S, Sifaki K, Malamas M, Nikiforidis G, Solomou E: Enhancing the discrimination accuracy between metastases, gliomas and meningiomas on brain MRI by volumetric textural features and ensemble pattern recognition methods. Magn Reson Imaging; 2009 Jan;27(1):120-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to evaluate the efficiency of 3D textural features using a pattern recognition system in the task of discriminating benign, malignant and metastatic brain tissues on T1 postcontrast MR imaging (MRI) series.
  • The dataset consisted of 67 brain MRI series obtained from patients with verified and untreated intracranial tumors.
  • The latter, in conjunction with using 3D textural features, enabled boosting up the performance of the system in discriminating metastatic, malignant and benign brain tumors with 77.14%, 89.19% and 93.33% accuracy, respectively.
  • The proposed system might be used as an assisting tool for brain tumor characterization on volumetric MRI series.
  • [MeSH-major] Brain Neoplasms / diagnosis. Glioma / diagnosis. Image Enhancement / methods. Imaging, Three-Dimensional. Magnetic Resonance Imaging / methods. Meningioma / diagnosis. Pattern Recognition, Automated / methods

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  • (PMID = 18602785.001).
  • [ISSN] 0730-725X
  • [Journal-full-title] Magnetic resonance imaging
  • [ISO-abbreviation] Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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10. Moliterno JA, Sood S, Zambrano E, Kim JH, Piepmeier JM, Baehring JM: Intracranial benign fibrous histiocytomas: a case report and review. J Neurooncol; 2009 Apr;92(2):203-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial benign fibrous histiocytomas: a case report and review.
  • They are uncommon as an intracranial lesion.
  • Although there have been several reports about malignant fibrous histiocytomas, less is known about the benign variant of these intracranial tumors as they are often misclassified as other types of tumors.
  • Pathology revealed benign fibrous histiocytoma.
  • We also review other cases reported in the literature in an effort to provide further insight into the diagnosis and management of this rare tumor.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / surgery. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery

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  • (PMID = 19030779.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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11. Hayashi Y, Uchiyama N, Hayashi Y, Nakada M, Iwato M, Kita D, Higashi R, Hirota Y, Kai Y, Kuratsu J, Hamada J: A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system. Clin Neurol Neurosurg; 2009 Jan;111(1):34-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system.
  • OBJECTIVES: Hemangiopericytomas (HPCs) are rare neoplasms with relatively high rates of recurrence and extracranial metastasis.
  • Though the differential diagnoses from angiomatous meningiomas and from solitary fibrous tumors (SFTs) are both important, the latter diagnosis is somewhat more important in light of the benign prognosis of SFTs and the difficulties in distinguishing SFTs from HPCs.
  • CONCLUSION: Our study suggests that a relatively high percentage of the tumors diagnosed as HPCs in the past may have in fact been intracranial SFTs.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Central Nervous System Neoplasms / diagnosis. Hemangiopericytoma / diagnosis. Meningioma / diagnosis. Solitary Fibrous Tumors / diagnosis

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  • (PMID = 18922629.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 0 / Vimentin
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12. Akamatsu T, Tanaka R, Fukui T, Miyasaka M, Yamada S: A case of mushroom shape temporal bone osteoma. Tokai J Exp Clin Med; 2009 Sep;34(3):87-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A cranial vault Osteoma is relatively common benign tumor.
  • And the tumor was located over the right sigmoid sinus.
  • The sigmoid sinus engraved approximately 4mm to the tumor and had a branching to one emissaries' vein.
  • The tumor was excised first by cutting the base of the tumor, and then residual tumor was grinded using a round head cutting bar.
  • Histological findings were consistent with a benign osteoma.
  • CT examination immediately done after operation revealed no evidence of intracranial hemorrhage, or injury of vessels.
  • [MeSH-major] Osteoma / pathology. Skull Neoplasms / pathology. Temporal Bone / pathology

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  • (PMID = 21319006.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Lee J, Lee BL, Joo EY, Seo DW, Hong SB, Hong SC, Suh YL, Lee M: Dysembryoplastic neuroepithelial tumors in pediatric patients. Brain Dev; 2009 Oct;31(9):671-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Dysembryoplastic neuroepithelial tumors (DNTs) are benign cortical tumors that are frequently associated with the medically intractable focal epilepsy.
  • The adopted surgical methods were uniform according to the tumor location and included intraoperative electrocorticography (ECoG)-guided resection.
  • Therefore, complete removal of the CD with tumor itself is important for patient outcome.
  • A thorough surgical approach can be accomplished by comprehensive presurgical evaluations and extensive surgery with the aid of the intraoperative ECoG or intracranial recording.
  • [MeSH-major] Brain / pathology. Brain Neoplasms / surgery. Epilepsy / surgery. Neoplasms, Neuroepithelial / surgery

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  • (PMID = 19058938.001).
  • [ISSN] 1872-7131
  • [Journal-full-title] Brain & development
  • [ISO-abbreviation] Brain Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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14. Deb P, Sarkar C, Garg A, Singh VP, Kale SS, Sharma MC: Intracranial gliofibroma mimicking a meningioma: a case report and review of literature. Clin Neurol Neurosurg; 2006 Feb;108(2):178-86
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  • [Title] Intracranial gliofibroma mimicking a meningioma: a case report and review of literature.
  • Gliofibromas are rare glio-mesenchymal tumors composed of astrocytic and benign mesenchymal components, which commonly occur in the first two decades of life.
  • Post-operatively, the residual tumor regrew to a size similar to the initial mass (4 cm x 3.6 cm x 3.5 cm), within one and a half years after the first surgery.
  • The histopathology of the tumor was similar on both occasions.
  • Although a poor prognosis has been characteristically noted in gliofibromas with high-grade glial component, but the present case had recurrence despite being of low-grade, thus highlighting the uncertain behaviour of this rare tumor.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Fibroma / diagnosis. Glioma / diagnosis. Meningioma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Third Ventricle

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  • (PMID = 16412839.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 24
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15. Moser A, Hoffmann KM, Walch C, Sovinz P, Lackner H, Schwinger W, Benesch M, Fritz G, Urban C: Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl. J Pediatr Hematol Oncol; 2008 Dec;30(12):935-7
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  • [Title] Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl.
  • Imaging studies revealed an intracranial mass of the right temporal bone causing temporal lobe displacement.
  • A first biopsy led to the diagnosis of intracranial giant cell reparative granuloma (GCRG), a rare benign tumor of the bone or soft tissue that can show expansive growth.
  • Facial nerve palsy responded to treatment with diclofenac and physiotherapy, however, the intracranial lesion progressed at follow-up.
  • Cholesteatoma should be considered as a trigger for intracranial GCRG growth, especially if adjacent to the temporal bone.

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  • (PMID = 19131785.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 144O8QL0L1 / Diclofenac
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16. Bollo RJ, Zagzag D, Samadani U: Synchronous choroid plexus papilloma of the fourth ventricle and ependymoma of the filum terminale: case report. Neurosurgery; 2010 Nov;67(5):E1454-9; discussion E1459
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  • After pathological diagnosis of a choroid plexus papilloma, the patient underwent resection of the spinal cord tumor.
  • CONCLUSION: This case underscores the need for separate pathological diagnosis in a patient with an intradural spine lesion in the context of a benign intracranial lesion.
  • [MeSH-major] Cauda Equina / surgery. Choroid Plexus Neoplasms / surgery. Ependymoma / surgery. Neoplasms, Multiple Primary / surgery. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 20871433.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Benatiya Andaloussi I, Touiza E, Bhallil S, Oudidi A, Bouayed MA, Daoudi K, El Alami MN, Tahri H: Orbital osteoma: three case reports. Bull Soc Belge Ophtalmol; 2006;(300):73-9
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  • INTRODUCTION: Osteoma is the most frequent benign tumor of paranasal sinuses.
  • The management consisted in a surgical excision of the whole tumor by external approach, associated with a dacryocystorhinostomy.
  • The tumor was removed through an external ethmoidectomy.
  • They rarely show intraorbital extension or cause intracranial complications.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Osteoma / diagnosis

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  • (PMID = 16903514.001).
  • [ISSN] 0081-0746
  • [Journal-full-title] Bulletin de la Société belge d'ophtalmologie
  • [ISO-abbreviation] Bull Soc Belge Ophtalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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18. Chesnokova V, Melmed S: Pituitary tumour-transforming gene (PTTG) and pituitary senescence. Horm Res; 2009 Apr;71 Suppl 2:82-7
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  • Pituitary tumours account for 15% of intracranial neoplasms and are benign monoclonal neoplasms that may be clinically silent or secrete hormones, including prolactin, growth hormone, adrenocorticotrophic hormone or, rarely, thyroid-stimulating hormone or gonadotrophins.
  • We explored the role of disordered pituitary cell proliferation control in the pathogenesis of these invariably benign adenomas, studying the mechanisms underlying pituitary aneuploidy, premature proliferative arrest (senescence), markers of cell proliferation and tumorigenesis in single, double or triply mutant transgenic mice with mutations of Rb, Pttg and/or p21.
  • [MeSH-major] Brain Neoplasms / metabolism. Cell Aging. Cell Cycle. Mutation. Neoplasm Proteins / metabolism. Pituitary Neoplasms / metabolism

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19407503.001).
  • [ISSN] 1423-0046
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Pituitary Hormones; 0 / Retinoblastoma Protein; 0 / Securin; 0 / pituitary tumor-transforming protein 1, human
  • [Number-of-references] 38
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19. Isobe N, Oki S, Murakami T, Ooyama S, Kureshima M, Kurokawa Y: [A case of atypical meningioma with Lhermitte-Duclos disease]. No Shinkei Geka; 2005 Dec;33(12):1229-35
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  • Lhermitte-Duclos disease is known as an uncommon disease that characterized by a slowly progressive tumor of the cerebellar hemisphere.
  • But, the patient had neither cerebellar dysfunction nor signs of increased intracranial pressure.
  • The patient had angioma of the left breast and bilateral benign struma, no typical manifestation of Cowden syndrome.
  • Removal of the frontal tumor caused the convulsion was subsequently performed.
  • After the operation, radiation therapy was not done because of the total removal of tumor and intension on patient side.
  • [MeSH-major] Cerebellar Neoplasms / complications. Ganglioneuroma / complications. Meningeal Neoplasms / complications. Meningioma / complications

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  • (PMID = 16359035.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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20. Shellhaas RA, Smith SE, O'Tool E, Licht DJ, Ichord RN: Mimics of childhood stroke: characteristics of a prospective cohort. Pediatrics; 2006 Aug;118(2):704-9
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  • OBJECTIVES: Our goal was to describe patients with stroke mimics and to determine if clinical features predict benign diagnoses.
  • Cases in which stroke was ruled out (stroke mimics) were reviewed for clinical features and diagnostic test results and were classified "benign" if there was no structural brain lesion and there was an expectation of complete recovery.
  • Eleven patients had "benign" diagnoses (3 migraine, 3 psychogenic diagnoses, 3 musculoskeletal abnormalities, 1 delirium, and 1 episodic vital sign changes).
  • Nineteen patients had "not-benign" diagnoses (3 reversible posterior leukoencephalopathy syndrome, 3 neonatal seizures, 2 vascular anomalies, 2 inflammatory disease, 2 intracranial infection, 2 epilepsy, 2 metabolic stroke, 1 tumor, 1 drug toxicity, and 1 idiopathic intracranial hypertension).
  • Except for the presence of seizures, there were no significant differences in presentation or risk factors between benign and not-benign cases.
  • History and clinical presentation often do not distinguish the one third of patients with benign disorders from the two thirds with more serious problems, necessitating timely comprehensive investigations, especially brain MRI.
  • [MeSH-minor] Adolescent. Brain Neoplasms / complications. Brain Neoplasms / diagnosis. Child. Child, Preschool. Cohort Studies. Consciousness Disorders / etiology. Diagnosis, Differential. Diagnostic Imaging. Female. Headache / etiology. Hemiplegia / etiology. Humans. Intracranial Hypertension / complications. Intracranial Hypertension / diagnosis. Male. Muscle Weakness / etiology. Prospective Studies. Seizures / etiology. Sensation Disorders / etiology


21. Noudel R, Chauvet E, Cahn V, Mérol JC, Chays A, Rousseaux P: Transcranial resection of a large sinonasal juvenile psammomatoid ossifying fibroma. Childs Nerv Syst; 2009 Sep;25(9):1115-20
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  • INTRODUCTION: Juvenile psammomatoid ossifying fibroma (JPOF) is a benign but potentially locally aggressive fibroosseous lesion predominantly arising in the paranasal sinuses in children and young adults.
  • Intracranial extension is rare but occurs sometimes.
  • In such cases, tumor resection may often require the combination of neurosurgical and facial approaches.
  • Despite the tumor had eroded through nasal septum, medial orbit wall, and right maxilla, it could be entirely removed performing an extended frontobasal approach via a bifrontoorbital craniotomy, obviating the need for a transfacial approach.
  • [MeSH-major] Fibroma, Ossifying / surgery. Skull Neoplasms / surgery

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  • [Cites] Cancer. 1995 Oct 1;76(7):1155-65 [8630892.001]
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  • (PMID = 19308423.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Bilginer B, Söylemezoğlu F, Cila A, Akalan N: Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor. Turk Neurosurg; 2009 Jan;19(1):69-72
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  • [Title] Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor.
  • Dysembryoplastic neuroepithelial tumor (DNT)- like lesions arise in extracortical locations and behave in a benign fashion similar to that of cortical DNTs.
  • They usually come to attention by symptoms and signs of increased intracranial pressure rather than focal neurological impairment.
  • A third ventricular mass lesion with disseminated spinal tumor was detected on his magnetic resonance imaging.
  • The presence of floating neurons in a mucinous matrix, oligodendrocyte-like cells (OLCs) aligning axonal columns and vessels, immunohistochemical profile of the neoplasm in addition to the clinical and radiological manifestations of the patient led to the diagnosis of "DNT-like neoplasm of the third ventricle".
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Magnetic Resonance Imaging. Neoplasms, Neuroepithelial / secondary. Spinal Neoplasms / secondary. Teratoma / secondary

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  • (PMID = 19263357.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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23. Rim NJ, Kim HS, Kim SY: A "benign" sphenoid ridge meningioma manifesting as a subarachnoid hemorrhage associated with tumor invasion into the middle cerebral artery. Korean J Radiol; 2008 Jul;9 Suppl:S10-3
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  • [Title] A "benign" sphenoid ridge meningioma manifesting as a subarachnoid hemorrhage associated with tumor invasion into the middle cerebral artery.
  • Meningioma rarely manifests as a subarachnoid hemorrhage (SAH), and invasion directly into a major intracranial artery is extremely rare.
  • To the best of our knowledge, meningioma presenting with an SAH associated with major intracranial arterial invasion has never been reported.
  • We present a case of sphenoid ridge meningotheliomatous meningioma manifesting as an SAH without pathologically atypical or malignant features, due to direct tumor invasion into the middle cerebral artery.
  • [MeSH-major] Meningeal Neoplasms / complications. Meningioma / complications. Middle Cerebral Artery / pathology. Skull Neoplasms / complications. Sphenoid Bone. Subarachnoid Hemorrhage / etiology
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • [Cites] Acta Neurochir (Wien). 2000;142(2):165-8 [10795890.001]
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  • (PMID = 18607117.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627185
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24. Sayagués JM, Tabernero MD, Maíllo A, Trelles O, Espinosa AB, Sarasquete ME, Merino M, Rasillo A, Vera JF, Santos-Briz A, de Alava E, Garcia-Macias MC, Orfao A: Microarray-based analysis of spinal versus intracranial meningiomas: different clinical, biological, and genetic characteristics associated with distinct patterns of gene expression. J Neuropathol Exp Neurol; 2006 May;65(5):445-54
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  • [Title] Microarray-based analysis of spinal versus intracranial meningiomas: different clinical, biological, and genetic characteristics associated with distinct patterns of gene expression.
  • Here, we compare the clinico-biological characteristics as well as the genetic abnormalities and patterns of gene expression of spinal and intracranial meningiomas.
  • Fourteen spinal and 141 intracranial meningioma patients were analyzed at diagnosis.
  • Additionally, microarray analyses were performed on a subgroup of 18 histologically benign meningiomas (7 spinal and 11 intracranial).
  • Upon comparison with intracranial tumors, spinal meningiomas showed a marked predominance of psammomatous and transitional tumors (p = 0.001), together with a higher proportion of cases displaying a single tumor cell clone by iFISH (p = 0.004).
  • In 86% of the spinal versus 56% of the intracranial tumors (p = 0.01), the ancestral tumor cell clone detected showed either absence of any chromosomal abnormality or monosomy 22/22q- alone.
  • Analysis of gene expression profiles showed differential expression between spinal and intracranial meningiomas for a total of 1555 genes, 35 of which allowed a clear distinction between both tumor types.
  • Most of these 35 genes (n = 30) showed significantly higher expression among spinal tumors and corresponded to genes involved in signal transduction pathways, which did not show a significantly different expression according to tumor histopathology.
  • In summary, we show the occurrence of unique patterns of genetic abnormalities and gene expression profiles in spinal as compared to intracranial meningiomas that provide new insights into the molecular pathways involved in the tumorigenesis and progression of spinal meningiomas, and could help explain their particular clinical and histological features.
  • [MeSH-major] Gene Expression / physiology. Meningeal Neoplasms / genetics. Meningioma / genetics. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16772868.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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25. Keller A, Ludwig N, Comtesse N, Hildebrandt A, Meese E, Lenhof HP: A minimally invasive multiple marker approach allows highly efficient detection of meningioma tumors. BMC Bioinformatics; 2006;7:539
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  • Our approach uses statistical learning techniques applied to multiple antigen tumor antigen markers utilizing the immune system as a very sensitive marker of molecular pathological processes.
  • For validation purposes we choose the intracranial meningioma tumors as model system since they occur very frequently, are mostly benign, and are genetically stable.
  • Detailed analysis revealed that prediction performs particularly well on low-grade (WHO I) tumors, consistent with our goal of early stage tumor detection.
  • Remarkably, our study proves that the inclusion of non-specific antigens, detected not only in tumor but also in normal sera, increases the performance significantly, since non-specific antigens contribute additional diagnostic information.
  • [MeSH-major] Algorithms. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / immunology. Meningioma / diagnosis. Meningioma / immunology

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  • (PMID = 17184519.001).
  • [ISSN] 1471-2105
  • [Journal-full-title] BMC bioinformatics
  • [ISO-abbreviation] BMC Bioinformatics
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC1769403
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26. Rahmah NN, Horiuchi T, Nakayama J, Nitta J, Hongo K: Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma? Surg Neurol Int; 2010;1:60
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  • BACKGROUND: The authors report a rare case of a patient with previously treated cutaneous malignant melanoma that recurred 1 year later as an intracranial meningioma.
  • Imaging study revealed an enhanced intracranial extradural mass with bone destruction.
  • Histological study revealed the intracranial mass to be an atypical meningioma.
  • CONCLUSION: To our knowledge, this is a rare report of a patient with this tumor occurrence.
  • This case serves to remind neurosurgeons of the potential existence of benign and/ or malignant tumors of neural crest origin.

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  • (PMID = 20975977.001).
  • [ISSN] 2152-7806
  • [Journal-full-title] Surgical neurology international
  • [ISO-abbreviation] Surg Neurol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2958332
  • [Keywords] NOTNLM ; Malignant melanoma / coexistence-losomarginal artery / meningioma / neural crest / recurrence
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27. Kuroda H, Kashimura H, Ogasawara K, Sugawara A, Sasoh M, Arai H, Ogawa A: Malignant intracranial meningioma with spinal metastasis--case report. Neurol Med Chir (Tokyo); 2009 Jun;49(6):258-61
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  • [Title] Malignant intracranial meningioma with spinal metastasis--case report.
  • The tumor was histologically benign at the first operation, but exhibited unusually aggressive behavior after failed radiosurgery and demonstrated clinical characteristics of malignancy such as spinal metastasis.
  • The patient underwent gamma knife radiosurgery (GKR) for recurrence after the first operation, despite the tumor being located in a resectable region.
  • The tumor did not respond.
  • Retrospectively, we speculate that if a tumor is located in a resectable region and Simpson grade I or II tumor resection is possible, direct surgery may be a safer option than GKR.
  • [MeSH-major] Cell Transformation, Neoplastic / radiation effects. Meningeal Neoplasms / pathology. Meningioma / secondary. Neoplasm Metastasis / physiopathology. Radiosurgery / adverse effects. Spinal Cord Neoplasms / secondary

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  • (PMID = 19556736.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM: Epidemiology of intracranial meningioma. Neurosurgery; 2005 Dec;57(6):1088-95; discussion 1088-95
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  • [Title] Epidemiology of intracranial meningioma.
  • Meningiomas are the most frequently reported primary intracranial neoplasms, accounting for approximately 25% of all such lesions diagnosed in the United States.
  • Recent legislation passed in the United States (The Benign Brain Tumor Cancer Registries Amendment Act [H.R.
  • 5204]) mandates registration of benign brain tumors such as meningioma.
  • The increased emphasis on research dedicated to the study of brain tumors coupled with the advent of new tools in genetic and molecular epidemiology make the current era an ideal time to advance knowledge for intracranial meningioma.

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  • (PMID = 16331155.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R25 CA089017; United States / NCI NIH HHS / CA / 5R25-CA089017-03; United States / NCI NIH HHS / CA / P50-CA097257; United States / NCI NIH HHS / CA / R01-CA52689
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 76
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29. Yu T, Zeng C, Zhao JZ: [Intracranial subependymoma: clinical features and surgical management of 22 cases]. Zhonghua Yi Xue Za Zhi; 2010 Mar 23;90(11):756-9
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  • [Title] [Intracranial subependymoma: clinical features and surgical management of 22 cases].
  • OBJECTIVE: To study the clinical features, neuro-radiology and treatment of intracranial subependymomas.
  • One tumor was located in temporal lobe, mesencephalon, thalamus and pons.
  • CONCLUSION: Intracranial subependymoma is a rare benign tumor.
  • The prognosis is excellent and there is a rare tumor recurrence.
  • [MeSH-major] Brain Neoplasms. Glioma, Subependymal


30. Janaki MG, Nirmala S, Rajeev AG: Nasopharyngeal angiofibroma treated with radiotherapy. J Cancer Res Ther; 2007 Apr-Jun;3(2):100-1
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  • Nasopharyngeal angiofibroma is a rare, highly vascular, benign, locally aggressive tumor, affecting boys of adolescent age.
  • Although surgery is the treatment of choice in early cases, considerable debate exists regarding the treatment of advanced disease with intracranial extension.
  • [MeSH-major] Angiofibroma / radiotherapy. Nasopharyngeal Neoplasms / radiotherapy

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  • (PMID = 17998732.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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31. Bambakidis NC, Nakaji P: Surgical treatment of meningiomas. Front Biosci (Elite Ed); 2009;1:587-99
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  • Meningiomas, though benign histologically, are relatively common tumors that may behave in an aggressive, clinical fashion.
  • This may be curative, but it has become clear that the degree of surgical resection achieved is a primary determinant of the rate of tumor recurrence.
  • The following article describes general principles of surgical treatment as well as some of the pitfalls inherent in treating meningiomas in specific intracranial locations.
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local. Postoperative Complications

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  • (PMID = 19482675.001).
  • [ISSN] 1945-0508
  • [Journal-full-title] Frontiers in bioscience (Elite edition)
  • [ISO-abbreviation] Front Biosci (Elite Ed)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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32. Ahmadi SA, Samadi N: Evaluation of argyrophilic nucleolar organizer region staining in predicting the behavior of meningiomas. Ann Saudi Med; 2006 Jan-Feb;26(1):38-42
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  • Comparing nonrecurrent, recurrent, atypical and malignant meningiomas we studied the value of the routine applicability of the AgNOR count in the prognostication of this tumor.
  • Eighty-one cases were selected and arranged in six groups according to clinical data and grading: 14 benign non-recurrent meningiomas; 14 primary benign recurrent meningiomas and their subsequent benign recurrences; 14 atypical; 11 malignant and 14 spinal meningiomas.
  • RESULTS: There was a proportionate increase of AgNOR dots with increasing tumor grade.
  • There was a significant difference between benign non-recurrenttumors versus benign recurrent (P<0.0001) and atypical or malignant (P<0.0001) tumors.
  • A difference was also noted between the recurring tumors versus malignant ones (P = 0.002) but no significant difference was seen between recurrent and atypical; atypical and malignant; intracranial and intraspinal; and primary of recurring meningiomas with their subsequent recurrences.
  • A mean AgNOR count of <2.3 could separate benign tumors from atypical or malignant meningiomas with 93% specificity; and 93% of tumors with benign histology had no recurrence potential if their mean AgNOR count was less than 1.8.
  • CONCLUSION: This study indicates that in meningioma, the AgNOR count has a good correlation with tumor grading and recurrence, which may aid pathologists and clinicians in predicting tumor behavior.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Nucleolus Organizer Region / pathology

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  • (PMID = 16521873.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Coloring Agents
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33. Wang T, Wang X, Li M, Xu A, Chen Y: [Surgical approaches of anterior skull base tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Jan;21(2):50-1
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  • RESULT: Of the 27 malignant cases the 3 and 5-year survival rates were 81.9% (22/27) and 62.9% (17/27) respectively, and one tumor free case living well more than 9 years.
  • There were no recurrence in 10 cases with benign tumor.
  • CONCLUSIONS: Various craniofacial approaches except lateral rhinotomy provide directly satisfactory tumor exposure and facilitate enbloc resection of the naso paranasal sinus tumor with intracranial extension.
  • Partial or total maxillary swing combined with naso pyramid translocation is good for tumor involving the skull base without intracranial invasion.
  • The fronto-nasal pyramid translocation is good for removal of the upper part of nasal tumor with intracranial extension on well developed frontal sinus.
  • The fronto orbital approach is proper for removal of fronto-sphenoid tumor and midface degloving may be used in selected cases.
  • [MeSH-major] Craniotomy / methods. Skull Base / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 17438840.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Jacquin A, Béjot Y, Hervieu M, Biotti D, Caillier M, Ricolfi FC, Moreau T, Giroud M: [Rupture of intracranial dermoid cyst with disseminated lipid droplets]. Rev Neurol (Paris); 2010 Apr;166(4):451-7
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  • [Title] [Rupture of intracranial dermoid cyst with disseminated lipid droplets].
  • INTRODUCTION: Dermoid cysts are rare slow-growing benign tumors of the central nervous system generally diagnosed in the third to fifth decade.
  • CASE REPORTS: We report two cases of ruptured intracranial dermoid tumor with non-specific clinical presentations.
  • [MeSH-major] Brain Neoplasms / pathology. Dermoid Cyst / pathology. Lipid Metabolism / physiology

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19846186.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. Mehta N, Bhagwati S, Parulekar G: Meningiomas in children: A study of 18 cases. J Pediatr Neurosci; 2009 Jul;4(2):61-5
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  • BACKGROUND: Intracranial meningiomas are rare tumors in children accounting for 0.4-4.6% of all primary brain tumors in the age group of 0-18 years.
  • Total tumor excision was achieved in all cases.
  • Children with complete resection and a typical benign histology have a good prognosis.

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  • [ISSN] 1817-1745
  • [Journal-full-title] Journal of pediatric neurosciences
  • [ISO-abbreviation] J Pediatr Neurosci
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36. Health Quality Ontario: Functional brain imaging: an evidence-based analysis. Ont Health Technol Assess Ser; 2006;6(22):1-79
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  • The addition of MRS or O-(2-(18)F-Fluoroethyl)-L-Tyrosine (FET)-PET to gadolinium (Gd)-enhanced MRI for distinguishing malignant from benign tumours during primary diagnosis may provide a higher specificity than Gd-enhanced MRI alone.
  • The clinical utility of additional imaging in patients to distinguish malignant from benign tumours is unclear, because patients with a suspected brain tumour will likely undergo a biopsy despite additional imaging results.
  • Based on the studies available, it is unclear if MEG has similar accuracy in localizing seizure foci to intracranial electroencephalogram (ICEEG).

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  • (PMID = 23074493.001).
  • [ISSN] 1915-7398
  • [Journal-full-title] Ontario health technology assessment series
  • [ISO-abbreviation] Ont Health Technol Assess Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3379170
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37. Gallina P, Buccoliero AM, Mariotti F, Mennonna P, Di Lorenzo N: Oncocytic meningiomas: Cases with benign histopathological features and a favorable clinical course. J Neurosurg; 2006 Nov;105(5):736-8
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  • [Title] Oncocytic meningiomas: Cases with benign histopathological features and a favorable clinical course.
  • OBJECT: Oncocytic meningioma has recently been recognized as a distinct morphological variant of intracranial meningothelial neoplasms, and only a few cases have been reported in the literature.
  • METHODS: The authors report on five cases of intracranial oncocytic meningiomas.
  • At the last follow-up evaluation, all patients were asymptomatic and magnetic resonance imaging examinations demonstrated no evidence of tumor recurrence.
  • In fact, the histological features as well as the long-term favorable clinical course may suggest benign behavior of such neoplasms, as in the common forms of meningiomas.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery. Oxyphil Cells / physiology

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  • (PMID = 17121136.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody
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38. Bledsoe JM, Link MJ, Stafford SL, Park PJ, Pollock BE: Radiosurgery for large-volume (&gt; 10 cm3) benign meningiomas. J Neurosurg; 2010 May;112(5):951-6
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  • [Title] Radiosurgery for large-volume (> 10 cm3) benign meningiomas.
  • OBJECT: Stereotactic radiosurgery (SRS) has proven to be a safe and effective treatment for many patients with intracranial meningiomas.
  • The average tumor volume was 17.5 cm3 (range 10.1-48.6 cm3); the average tumor margin dose was 15.1 Gy (range 12-18 Gy); and the mean follow-up duration was 70.1 months (range 12-199 months).
  • RESULTS: Tumor control was 99% at 3 years and 92% at 7 years after radiosurgery.
  • CONCLUSIONS: The morbidity associated with SRS for patients with benign meningiomas > 10 cm(3) is greater for supratentorial tumors compared with skull base tumors.
  • [MeSH-major] Meningioma / pathology. Meningioma / surgery. Radiosurgery / instrumentation. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ataxia / epidemiology. Ataxia / etiology. Cerebral Infarction / epidemiology. Cerebral Infarction / etiology. Female. Follow-Up Studies. Headache / epidemiology. Headache / etiology. Hearing Disorders / epidemiology. Hearing Disorders / etiology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Supratentorial Neoplasms / pathology. Supratentorial Neoplasms / surgery. Young Adult

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  • [CommentIn] J Neurosurg. 2010 Dec;113(6):1335-6; author reply 1336-7 [20887089.001]
  • (PMID = 19764829.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Kantha R, Saffari HM, Suryati MY: The relationship of p53 protein in meninigioma grading and their various influencing factors amongst neurosurgical patients in Hospital Kuala Lumpur. Med J Malaysia; 2007 Aug;62(3):194-6
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  • Meningioma, is the second most frequent intracranial tumor in Malaysia and are classified according to the World Health Organization classification.
  • The relationship of p53 protein in the determination of meningioma grading and their influencing factors were studied via immunohistochemistry studies on 77 intracranial meningiomas (67 benign, 10 atypical).
  • The higher the p53 reaction was correlated to the poorer the histological grade (19.4% in benign and 90% in atypical meningioma) (p < 0.001).
  • [MeSH-major] Brain Neoplasms / pathology. Meningioma / classification. Tumor Suppressor Protein p53

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  • (PMID = 18246905.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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40. Alexiou GA, Vartholomatos G, Tsiouris S, Papadopoulos A, Kyritsis AP, Polyzoidis KS, Voulgaris S, Fotopoulos AD: Evaluation of meningioma aggressiveness by (99m)Tc-Tetrofosmin SPECT. Clin Neurol Neurosurg; 2008 Jul;110(7):645-8
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  • OBJECTIVES: Although meningiomas usually have a benign clinical course, atypical and malignant types of this brain tumor are associated with high recurrence rates and poor outcome; thus, DNA ploidy and S-phase -- as determined by DNA flow cytometry -- are useful indicators of their biological behavior.
  • PATIENTS AND METHODS: Ten consecutive patients (3 males, 7 females, mean age 64.6 years) with a diagnosis of a symptomatic intracranial meningioma, planned to undergo surgery, were studied.
  • RESULTS: Benign meningiomas were diagnosed in 8/10 cases, the remaining 2/10 patients had anaplastic lesions.
  • There was also a positive correlation between tracer uptake and the level of aneuploidy and tumor grade.
  • CONCLUSION: These results imply that (99m)Tc-TF brain SPECT may have the ability to discriminate benign meningiomas from malignant meningiomas pre-operatively, the tracer uptake being a likely indicator of their proliferative activity.
  • [MeSH-major] Meningeal Neoplasms / radionuclide imaging. Meningioma / radionuclide imaging. Organophosphorus Compounds. Organotechnetium Compounds. Tomography, Emission-Computed, Single-Photon / methods
  • [MeSH-minor] Aged. Cell Cycle. Female. Flow Cytometry. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Reproducibility of Results. Tomography, X-Ray Computed

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  • (PMID = 18471956.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
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41. D'Angelo VA, Galarza M, Catapano D, Monte V, Bisceglia M, Carosi I: Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases. Neurosurgery; 2008 Jun;62(6 Suppl 3):1066-75
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  • [Title] Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases.
  • We conducted a retrospective study of patients with these lesions treated with a surgical strategy on the basis of tumor origin: primary or secondary ventricular and associated transependymal development.
  • Raised intracranial pressure occurred in 53% of patients, followed by mental disturbances or psychiatric symptoms (32%) and motor deficits (21%).
  • Sixty-five percent of tumors were benign and low-grade tumors.
  • CONCLUSION: Lateral ventricle tumors can be treated best by careful selection of the approach according to tumor origin and development.

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  • [ReprintOf] Neurosurgery. 2005 Jan;56(1 Suppl):36-45; discussion 36-45 [15799791.001]
  • (PMID = 18695527.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Looi A, Kazim M, Cortes M, Rootman J: Orbital reconstruction after eyelid- and conjunctiva-sparing orbital exenteration. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):1-6
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  • Average follow-up period was 21 months, during which one patient had development of intracranial meningioma at the proximal end of the optic canal.
  • Case selection is emphasized, as this technique is mainly reserved for histopathologically benign orbital lesions that exhibit local aggressive behavior and for malignant lesions only if there is no eyelid, lacrimal gland, or orbital fissure involvement nor significant conjunctival or deep extension of an intraocular tumor.
  • [MeSH-minor] Adult. Aged. Child. Eye Neoplasms / surgery. Female. Follow-Up Studies. Humans. Male. Retrospective Studies

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  • (PMID = 16418657.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Diensthuber M, Lenarz T, Stöver T: [Neurotrophic factor expression in vestibular schwannoma. An overview]. Laryngorhinootologie; 2006 Oct;85(10):731-7
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  • The vestibular schwannoma is a benign, slow-growing neoplasm that originates from the neurolemmal sheath of the vestibular branch of the VIIIth cranial nerve.
  • This tumor entity accounts for 6 % of all intracranial tumors and the annual incidence of newly diagnosed vestibular schwannoma is reported as 13 per million.
  • The molecular pathogenesis of both sporadic vestibular schwannoma and those occurring in neurofibromatosis type II appears to be associated with an aberration of a tumor suppressor gene on chromosome 22q12.
  • The results of recent immunohistochemical studies demonstrate the co-expression of transforming growth factor (TGF)-beta 1 and glial cell line-derived neurotrophic factor (GDNF) in vestibular schwannoma and suggest a trophic synergism of both neurotrophic factors in this tumor.
  • [MeSH-minor] Adult. Animals. Chromosomes, Human, Pair 22 / genetics. Epidermal Growth Factor / metabolism. Epidermal Growth Factor / physiology. Fibroblast Growth Factors / metabolism. Fibroblast Growth Factors / physiology. Genes, Tumor Suppressor. Glial Cell Line-Derived Neurotrophic Factor / metabolism. Glial Cell Line-Derived Neurotrophic Factor / physiology. Humans. Immunohistochemistry. Incidence. Mice. Mice, Hairless. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / metabolism. Neurofibromatosis 2 / pathology. Schwann Cells / metabolism. Schwann Cells / pathology. Signal Transduction. Transforming Growth Factors / metabolism. Transforming Growth Factors / physiology. Tumor Cells, Cultured. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor A / physiology

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  • (PMID = 16612755.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Nerve Growth Factors; 0 / Vascular Endothelial Growth Factor A; 62031-54-3 / Fibroblast Growth Factors; 62229-50-9 / Epidermal Growth Factor; 76057-06-2 / Transforming Growth Factors
  • [Number-of-references] 78
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44. Seizeur R, Josselin PM, Potard G, Besson G, Dam-Hieu P: [Capillary hemangioma of the ethmoid sinus. Case report and review of the literature]. Neurochirurgie; 2006 Dec;52(6):529-32
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  • Complete resection was obtained via ethmoid endoscopy combined with an intracranial approach.
  • Capillary hemangioma is a rare and benign vascular tumor in adults primarily developing in the skin and subcutaneous tissues of the head and neck, and/or within oral and nasal cavities.
  • [MeSH-major] Ethmoid Sinus / surgery. Hemangioma, Capillary / surgery. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 17203901.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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45. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ: Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol; 2009 Jun;68(6):626-32
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  • Hemangiomas are angiogenesis-dependent benign vascular tumors that can rupture and cause intracranial hemorrhages.

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  • (PMID = 19458547.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R21 NS050668-02; United States / NINDS NIH HHS / NS / P01 NS044155-05; United States / NINDS NIH HHS / NS / R21 NS050668; United States / NINDS NIH HHS / NS / P01 NS044155; United States / NINDS NIH HHS / NS / R01 NS027713; United States / NINDS NIH HHS / NS / R01 NS27713; United States / NINDS NIH HHS / NS / NS044155-05; United States / NINDS NIH HHS / NS / NS027713-17; United States / NINDS NIH HHS / NS / R21 NS50668; United States / NINDS NIH HHS / NS / P01 NS44145; United States / NINDS NIH HHS / NS / R01 NS027713-17; United States / NINDS NIH HHS / NS / NS050668-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Hif1a protein, mouse; 0 / Homeodomain Proteins; 0 / Hoxa5 protein, mouse; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Lectins; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Thrombospondins; 0 / thrombospondin 2
  • [Other-IDs] NLM/ NIHMS118393; NLM/ PMC2728585
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46. Chung IH, Lee YS, Myong NH, Lee MJ, Lee SK, Ko JH: Intracranial fibroxanthoma in an infant: a case report. Korean J Radiol; 2009 Jul-Aug;10(4):402-6
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  • [Title] Intracranial fibroxanthoma in an infant: a case report.
  • The tumor appeared as a large, well-circumscribed echogenic mass in the right parieto-occipital area on US.
  • The tumor was seen as isoattenuated to slightly hypoattenuated on pre-contrast CT scan and as hypometabolic on PET/CT.
  • [MeSH-major] Dura Mater. Histiocytoma, Benign Fibrous / diagnosis. Meningeal Neoplasms / diagnosis

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  • (PMID = 19568470.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2702051
  • [Keywords] NOTNLM ; Fibroxanthoma / Infantile brain tumor / Meningioma
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47. Püttmann S, Senner V, Braune S, Hillmann B, Exeler R, Rickert CH, Paulus W: Establishment of a benign meningioma cell line by hTERT-mediated immortalization. Lab Invest; 2005 Sep;85(9):1163-71
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  • [Title] Establishment of a benign meningioma cell line by hTERT-mediated immortalization.
  • Meningioma represents the most common intracranial tumor, but well-characterized cell lines derived from benign meningiomas are not available.
  • A major reason for the lack of benign tumor cell lines is senescence of nonmalignant cells in vitro, while malignant cells are often immortal.
  • Following subdural transplantation into nude mice, tumor tissue with typical histological features of meningothelial meningioma was found.
  • [MeSH-minor] Aged. Cell Line, Tumor. Female. Humans. Models, Biological. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15965488.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; EC 2.7.7.49 / Telomerase
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48. Kawamoto S, Matsuda H, Ueki K, Okada Y, Kim P: Neuromuscular choristoma of the oculomotor nerve: case report. Neurosurgery; 2007 Apr;60(4):E777-8; discussion E778
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  • OBJECTIVE: Neuromuscular choristomas (NMC) are rare benign tumors of the peripheral nerves.
  • INTERVENTION: The tumor was resected with the parental oculomotor nerve, which was reconstructed using a peroneal nerve graft.
  • CONCLUSION: NMC may need histological confirmation for diagnosis if they occur in the intracranial space.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurosurgical Procedures / methods. Oculomotor Nerve Diseases / surgery. Peroneal Nerve / transplantation. Rhabdomyoma / surgery

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  • (PMID = 17415185.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Ortega-Martínez M, Cabezudo-Artero JM, Fernández-Portales I, Pimentel JJ, Gómez de Tejada R: Diffuse leptomeningeal seeding from benign choroid plexus papilloma. Acta Neurochir (Wien); 2007 Dec;149(12):1229-36; discussion 1236-7
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  • [Title] Diffuse leptomeningeal seeding from benign choroid plexus papilloma.
  • Choroid plexus papillomas (CPP) are rare intracranial tumours with a favourable long-term outcome after surgical excision.
  • Although they are histologically benign, local recurrences may occasionally occur, but leptomeningeal dissemination is exceptional.
  • We review the literature concerning leptomeningeal dissemination of benign choroid plexus papillomas.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Fourth Ventricle / surgery. Meningeal Neoplasms / secondary. Neoplasm Seeding. Papilloma, Choroid Plexus / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Disease Progression. Fatal Outcome. Female. Humans. Ki-67 Antigen / analysis. Laminectomy. Magnetic Resonance Imaging. Meninges / pathology. Reoperation. S100 Proteins / analysis

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  • (PMID = 17924056.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / S100 Proteins
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50. Symss NP, Prasad AN, Vasudevan MC, Ramamurthi R: Exophytic choroid plexus papilloma of the fourth ventricle presenting with cerebrospinal fluid rhinorrhea: a case report. Surg Neurol; 2009 Jun;71(6):705-8
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  • BACKGROUND: Choroid plexus papillomas are rare benign neoplasms that arise from the ventricular choroid plexus and are considered to be of ependymal origin.
  • Six months later, he came to us with progressive loss of vision due to raised intracranial pressure.
  • Excision of the tumor takes precedence over any attempt to repair the fistula, as many a time, the CSF leak may stop.

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  • (PMID = 18313738.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Tonni G, De Felice C, Centini G, Ginanneschi C: Cervical and oral teratoma in the fetus: a systematic review of etiology, pathology, diagnosis, treatment and prognosis. Arch Gynecol Obstet; 2010 Oct;282(4):355-61
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  • (1) teratomas are rare, usually benign congenital tumors which recognized multifactorial etiology;.
  • (3) 3D ultrasound and MRI may enhance the accuracy of the antenatal diagnosis (location, extension and intracranial spread) and may aid in the selection of patients requiring treatment;.
  • (5) delivery should involve elective Cesarean section with ex utero intrapartum treatment procedure or resection of the tumor mass, which may be performed on placental support operation on placental support procedure to increase the chances of postnatal survival.
  • [MeSH-major] Fetus / surgery. Head and Neck Neoplasms. Mouth Neoplasms. Teratoma

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  • (PMID = 20473617.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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52. Strassner C, Buhl R, Mehdorn HM: Recurrence of intracranial meningiomas: did better methods of diagnosis and surgical treatment change the outcome in the last 30 years? Neurol Res; 2009 Jun;31(5):478-82
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  • [Title] Recurrence of intracranial meningiomas: did better methods of diagnosis and surgical treatment change the outcome in the last 30 years?
  • OBJECTIVE: Meningiomas are benign intracranial tumors growing from the arachnoid cap cells.
  • Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects.
  • METHODS: Between 1991 and 2002, 463 patients with an intracranial meningioma were operated in the Department of Neurosurgery, University of Kiel, Kiel, Germany.
  • We compared the outcome of these patients after operation and the different methods of radiation therapy and chemotherapy with the data from Buhl (1994), who analysed 661 patients with intracranial meningioma who were operated on in the Department of Neurosurgery, University of Essen, Essen, Germany, between 1968 and 1988, to find out whether better methods of diagnosis like magnetic resonance imaging scans, magnetic resonance spectroscopy, post-operative radiation therapy and chemotherapy have an influence on the recurrence and outcome after surgical treatment.
  • Both studies underlined the preponderance of female patients for intracranial meningiomas.
  • Complete removal of the tumor was possible in 86.7% in both studies.
  • The intracranial localization of the meningiomas was similar to the distribution of the histological subtypes and the rate of recurrence; only the malignant meningiomas showed a higher grade of recurrence in the last study.
  • The outcome of the patients after surgical removal was improving in the last years; the 30 day post-operative mortality after a primary operation on an intracranial meningioma decreased from 12.1 to 3%.
  • With better operating modalities and additional treatment with radiation and gamma knife, the mortality decreased significantly from 12 to 3% and the outcome of the patients is still improving, so that even elderly patients with intracranial meningioma can undergo surgical treatment with minor risks.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / therapy. Meningioma / diagnosis. Meningioma / therapy
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiosurgery. Time Factors. Treatment Outcome

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  • (PMID = 19500450.001).
  • [ISSN] 0161-6412
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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53. Muzumdar D, Ventureyra EC: Tonsillar herniation and cervical syringomyelia in association with posterior fossa tumors in children: a case-based update. Childs Nerv Syst; 2006 May;22(5):454-9
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  • They frequently present with raised intracranial pressure and may have tonsillar herniation.
  • The symptomatology is predominantly directed towards the tumor.
  • CASE REPORT: We describe a case of a pilocytic astrocytoma of the cerebellum in a 13-year-old girl who presented with clinical features of progressively worsening raised intracranial pressure and secondary tonsillar herniation and cervical syringomyelia.
  • Magnetic resonance (MR) imaging showed a large midline inhomogenously enhancing vermian tumor causing moderate obstructive hydrocephalus.
  • The tumor was resected through a suboccipital craniectomy.
  • CONCLUSIONS: The occurrence of tonsillar herniation and syringomyelia in association with a slow growing benign tumor like pilocytic astrocytoma of the cerebellum is uncommon.
  • Surgical extirpation of the tumor restores the normal cerebrospinal fluid circulation at the foramen magnum and produces an excellent outcome.
  • [MeSH-major] Astrocytoma. Hernia / etiology. Infratentorial Neoplasms / complications. Palatine Tonsil / pathology. Syringomyelia / etiology

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  • (PMID = 16397818.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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54. Frei-Jones M, McKinstry RC, Perry A, Leonard JR, Park TS, Rubin JB: Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma. J Neurosurg Pediatr; 2008 Aug;2(2):125-9
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  • [Title] Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma.
  • Infantile or capillary hemangioma is the most common vascular tumor of childhood.
  • The tumors most frequently affect the head and neck area, but rare cases of intracranial lesions have been reported.
  • Although the lesions are considered benign, 10% of affected children develop life-threatening complications (mortality rate 20-80% in this subgroup).
  • The authors present the case of an infant born with a life-threatening, unresectable intracranial hemangioma in which treatment with thalidomide resulted in a good clinical outcome.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Brain Neoplasms / congenital. Brain Neoplasms / drug therapy. Hemangioma, Capillary / congenital. Hemangioma, Capillary / drug therapy. Thalidomide / therapeutic use

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  • (PMID = 18671617.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K30 RR022251; United States / NCRR NIH HHS / RR / TL1 RR024995; United States / NCRR NIH HHS / RR / UL1 RR024992; United States / NCRR NIH HHS / RR / UL1 RR024992; United States / NCRR NIH HHS / RR / UL1 RR024992-01; United States / NCATS NIH HHS / TR / UL1 TR000448
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 4Z8R6ORS6L / Thalidomide
  • [Other-IDs] NLM/ NIHMS101679; NLM/ PMC2737696
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55. Navas M, Pedrosa-Sánchez M, Martínez-Flórez P, Carrasco R, Pascual JM, Sola RG: [Giant cavernous sinus haemangioma. Case report]. Neurocirugia (Astur); 2009 Oct;20(5):461-6
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  • INTRODUCTION: Intracranial haemangioma is a benign vascular tumor which seldom affects the cavernous sinus region, being it frequently misdiagnosed as a meningioma.
  • The tumor was partially removed through a left pterional approach, leaving an intraselar remnant.

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  • (PMID = 19830369.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 23
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56. Thielke D, Thyssen JP, Sejersen HM: [Cardiac myxoma--a rare cause of cerebral embolism]. Ugeskr Laeger; 2008 Aug 11;170(33):2460
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  • Cardiac myxoma is the most common benign heart tumor.
  • We report a case with multiple brain metastases, presumably due to tumor embolization.
  • Though myxoma is a rare cause of cerebral embolism, detection of this tumor is relatively easy and surgical resection of myxoma is usually a permanent measure to prevent subsequent stroke.
  • [MeSH-major] Brain Neoplasms / complications. Heart Neoplasms / complications. Intracranial Embolism / etiology. Myxoma / complications

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  • (PMID = 18761832.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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57. Feigl GC, Horstmann GA: Intracranial glomus jugulare tumors: volume reduction with Gamma Knife surgery. J Neurosurg; 2006 Dec;105 Suppl:161-7
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  • [Title] Intracranial glomus jugulare tumors: volume reduction with Gamma Knife surgery.
  • OBJECT: Glomus jugulare tumors (GJTs) are slow-growing benign tumors arising from paraganglion cells of the superior vagal ganglion.
  • The aim of our study was to further evaluate the role of Gamma Knife surgery (GKS) in the management of intracranial GJTs.
  • METHODS: Twelve consecutive patients (mean age 51.7 years) with intracranial GJTs were included in this study.
  • The treatment strategy was either multimodal, with microsurgical tumor volume reduction followed by GKS in patients suffering from brainstem compression, or GKS as the only treatment.
  • Follow-up examinations included thorough neurological examinations and neuroradiological quantitative volumetric tumor analysis.
  • Tumor volumes ranging from 1.6 to 24.8 cm3 were treated using prescription doses of 14 to 20 Gy (nine-28 isocenters).
  • The achieved overall tumor control rate after GKS was 100% (33 months mean follow up) with only mild side effects observed.
  • A tumor volume reduction (mean 41.1%; 3.2 cm3) was achieved in all patients.
  • CONCLUSIONS: Gamma Knife surgery is a safe and effective treatment for intracranial GJTs.
  • The tumor volume reductions achieved are comparable to those achieved using microsurgery but with a much lower rate of side effects.
  • [MeSH-major] Glomus Jugulare Tumor / pathology. Glomus Jugulare Tumor / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Male. Middle Aged. Prospective Studies. Radiotherapy Dosage. Recovery of Function. Treatment Outcome. Tumor Burden

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  • (PMID = 18503351.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Ahmed I, Auguste KI, Vachhrajani S, Dirks PB, Drake JM, Rutka JT: Neurosurgical management of intracranial epidermoid tumors in children. Clinical article. J Neurosurg Pediatr; 2009 Aug;4(2):91-6
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  • [Title] Neurosurgical management of intracranial epidermoid tumors in children. Clinical article.
  • OBJECT: Epidermoid tumors are benign lesions representing 1% of all intracranial tumors.
  • There have been few pediatric series of intracranial epidermoid tumors reported previously.
  • METHODS: The neurosurgical database at the Hospital for Sick Children was searched for children with surgically managed intracranial epidermoid tumors.
  • The average age at surgery was 11.2 years (range 8-15 years), and the mean maximal tumor diameter was 2.1 cm.
  • Headache was the most common presenting symptom, and 1 tumor was found incidentally.
  • CONCLUSIONS: Intracranial epidermoid tumors are rare in the pediatric population.
  • Total resection is desirable to minimize the risk of postoperative aseptic meningitis, hydrocephalus, and tumor recurrence.

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  • (PMID = 19645539.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Reddy JS, Mishra AM, Behari S, Husain M, Gupta V, Rastogi M, Gupta RK: The role of diffusion-weighted imaging in the differential diagnosis of intracranial cystic mass lesions: a report of 147 lesions. Surg Neurol; 2006 Sep;66(3):246-50; discussion 250-1
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  • [Title] The role of diffusion-weighted imaging in the differential diagnosis of intracranial cystic mass lesions: a report of 147 lesions.
  • BACKGROUND: The objective of this study is to evaluate the sensitivity and specificity of DWI in differentiating brain abscesses from other intracranial cystic lesions.
  • The ADC value of the tumor cysts (2.9 +/- 0.05 x 10(-3) mm(2)/s) was significantly lower (P = .02) compared with benign cysts and neurocysticercosis (3.2 +/- 0.05 x 10(-3) mm(2)/s) among nonabscess group.
  • CONCLUSIONS: Diffusion-weighted imaging has high sensitivity and specificity for the differentiation of brain abscess from other nonabscess intracranial cystic lesions.
  • [MeSH-major] Brain Abscess / diagnosis. Brain Neoplasms / diagnosis. Central Nervous System Cysts / diagnosis. Diffusion Magnetic Resonance Imaging / methods

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  • (PMID = 16935625.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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60. Corona AP, Oliveira JC, Souza FP, Santana LV, Rêgo MA: Risk factors associated with vestibulocochlear nerve schwannoma: systematic review. Braz J Otorhinolaryngol; 2009 Jul-Aug;75(4):593-615
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  • The vestibulocochlear nerve schwannoma (VS) is a benign tumor that stems from the edge of the Schwann s sheath.
  • It is considered the most frequent intracranial benign tumor, of low lethality rate and unknown etiology.

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  • (PMID = 19784431.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 49
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61. Suyama K, Ujifuku K, Hirao T, Takahata H, Ito M, Yonekura M, Nagata I: Symptomatic syringomyelia associated with a dermoid tumor in the posterior fossa. Neurol Med Chir (Tokyo); 2009 Sep;49(9):434-7
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  • [Title] Symptomatic syringomyelia associated with a dermoid tumor in the posterior fossa.
  • A 28-year-old female presented with a dermoid tumor in the posterior fossa associated with symptomatic syringomyelia.
  • Magnetic resonance (MR) imaging revealed cervical syringomyelia and tonsillar herniation concomitant with an intradural posterior fossa tumor which was totally removed.
  • The histological diagnosis was dermoid tumor.
  • Her symptoms subsided and MR imaging demonstrated complete resolution of the syrinx 12 months after tumor removal.
  • Benign congenital intracranial tumor may cause tonsillar herniation resulting in symptomatic cervical syringomyelia.
  • However, both tonsillar herniation and cervical syrinx may clinically and radiologically resolve following removal of the intracranial lesion and posterior fossa decompression.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cranial Fossa, Posterior / pathology. Dermoid Cyst / pathology. Infratentorial Neoplasms / pathology. Syringomyelia / etiology

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  • (PMID = 19779293.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Saito R, Kumabe T, Watanabe M, Jokura H, Shibuya M, Nakazato Y, Tominaga T: Low-grade fibromyxoid sarcoma of intracranial origin. J Neurosurg; 2008 Apr;108(4):798-802
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  • [Title] Low-grade fibromyxoid sarcoma of intracranial origin.
  • The low-grade fibromyxoid sarcoma is a rare sarcoma of the deep soft tissue that is characterized as an indolent but metastasizing soft-tissue neoplasm with a deceptively benign histological appearance.
  • Only one case of intracranial origin has been previously reported in the literature.
  • A high rate of local recurrence and eventual metastasis has been demonstrated for this tumor in deep soft tissue.
  • The tumor is still under control without any evidence of extracranial metastasis.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Sarcoma / diagnosis. Sarcoma / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Radiosurgery. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 18377261.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Seilicovich A, Pisera D, Sciascia SA, Candolfi M, Puntel M, Xiong W, Jaita G, Castro MG: Gene therapy for pituitary tumors. Curr Gene Ther; 2005 Dec;5(6):559-72
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  • Pituitary tumors are the most common primary intracranial neoplasms.
  • Although most pituitary tumors are considered typically benign, others can cause severe and progressive disease.
  • The principal aims of pituitary tumor treatment are the elimination or reduction of the tumor mass, normalization of hormone secretion and preservation of remaining pituitary function.

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  • (PMID = 16457646.001).
  • [ISSN] 1566-5232
  • [Journal-full-title] Current gene therapy
  • [ISO-abbreviation] Curr Gene Ther
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / U54 NS045309-010005; United States / NINDS NIH HHS / NS / 1 R01 NS 42893.01; United States / NINDS NIH HHS / NS / R21 NS047298; United States / NINDS NIH HHS / NS / 1R21 NS047298; United States / NINDS NIH HHS / NS / R01 NS044556; United States / NINDS NIH HHS / NS / 1R01 NS44556.01; United States / NINDS NIH HHS / NS / U54 4 NS045309; United States / NINDS NIH HHS / NS / U54 NS045309; United States / FIC NIH HHS / TW / 1R03 TW006273-01; United States / NINDS NIH HHS / NS / NS045309-010005; United States / NINDS NIH HHS / NS / R21 NS047298-01; United States / NINDS NIH HHS / NS / NS044556-01; United States / NINDS NIH HHS / NS / NS047298-01; United States / FIC NIH HHS / TW / R03 TW006273-01A1; United States / NINDS NIH HHS / NS / R01 NS042893; United States / NINDS NIH HHS / NS / R01 NS044556-01; United States / NINDS NIH HHS / NS / NS042893-01A1; United States / FIC NIH HHS / TW / TW006273-01A1; United States / NINDS NIH HHS / NS / R01 NS042893-01A1; United States / FIC NIH HHS / TW / R03 TW006273; United States / FIC NIH HHS / TW / 1R03 TW006273-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hormones
  • [Number-of-references] 148
  • [Other-IDs] NLM/ NIHMS100927; NLM/ PMC2696484
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64. Melone AG, Delfinis CP, Passacantilli E, Lenzi J, Santoro A: Intracranial extra-axial cavernous angioma of the cerebellar falx. World Neurosurg; 2010 Oct-Nov;74(4-5):501-4
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  • [Title] Intracranial extra-axial cavernous angioma of the cerebellar falx.
  • INTRODUCTION: Intracranial cavernous hemangiomas are benign vascular malformations that can be divided into intra-axial and extra-axial types.
  • The patient underwent surgery with en-bloc removal of the tumor.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Dura Mater / pathology. Hemangioma, Cavernous, Central Nervous System / pathology. Infratentorial Neoplasms / pathology. Meningeal Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21492602.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Ogino A, Yoshino A, Katayama Y, Watanabe T, Ota T, Komine C, Yokoyama T, Fukushima T: The p15(INK4b)/p16(INK4a)/RB1 pathway is frequently deregulated in human pituitary adenomas. J Neuropathol Exp Neurol; 2005 May;64(5):398-403
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  • Pituitary adenomas are common benign intracranial neoplasms.
  • Inactivation of genes involved in the negative cell-cycle regulatory p15(INK4b) - p16(INK4a) -cyclin D/CDK4-RB1-mediated pathway (RB1 pathway) is one of the most common and important mechanisms in the growth advantage of tumor cells.
  • Recently, much attention has been focused on the importance of alternative mechanisms of gene inactivation, particularly promoter hypermethylation in the transcriptional silencing of such tumor-suppressor genes.
  • [MeSH-major] Adenoma / metabolism. Cell Cycle Proteins / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Pituitary Neoplasms / metabolism. Retinoblastoma / genetics. Tumor Suppressor Proteins / metabolism

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  • (PMID = 15892297.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN2B protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Proteins
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66. Shuto T, Inomori S, Fujino H, Nagano H, Hasegawa N, Kakuta Y: Cyst formation following gamma knife surgery for intracranial meningioma. J Neurosurg; 2005 Jan;102(s_supplement):134-139
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  • [Title] Cyst formation following gamma knife surgery for intracranial meningioma.
  • OBJECT: The authors conducted a study to evaluate the clinical significance of cyst formation or enlargement after gamma knife surgery (GKS) for intracranial benign meningiomas.
  • METHODS: The medical records of 160 patients with 184 tumors were examined for those with follow-up data of more than 2 years among 270 patients who underwent GKS for intracranial meningiomas between February 1992 and November 2001.
  • The tumor location was the sphenoid ridge in one case, petroclival in two, tentorium in one, and parasagittal region in one.
  • The mean tumor volume was 10.5 cm<sup>3</sup>, the mean margin dose was 13.4 Gy (median 14 Gy), and the mean maximum dose was 27.5 Gy (median 24.1 Gy).
  • Histological examination demonstrated various findings such as tumor necrosis, proliferation of small vessels, vascular obliteration, and hemosiderin deposits.
  • CONCLUSIONS: New cyst formation following GKS for benign intracranial meningioma is relatively rare; however, both preexisting and newly developed cysts tend to enlarge after GKS and often require surgery.

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  • (PMID = 28306456.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; cyst / gamma knife surgery / meningioma
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67. Samadi N, Ahmadi SA: Meningioma: a clinicopathological evaluation. Malays J Med Sci; 2007 Jan;14(1):46-52
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  • 205(86.1%) cases were benign, 19(8%) atypical and 14(5.9%) malignant.
  • 181(18%) cases were primary and 51(27%) secondary; 35(68%) of the latter benign, 7(14%) atypical and 9(18%) malignant.
  • All intraspinal meningiomas were benign.
  • In benign cranial and spinal types female to male ratios were 1.9: 1 and 1.3: 1 ; while in atypical and malignant types were 1 :1.4 and 1:3.1 respectively.
  • Mean ages were 49.9 for benign.
  • The most frequent site of involvement in all grades of intracranial tumors was cerebral convexity (31.1 %).
  • Female preponderance seen in benign nonrecurrent meningioma became increasingly less prominent and even reversed in recurrent, atypical and malignant forms.
  • Benign recurrent tumors were similar to non-recurrent tumors microscopically.

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  • (PMID = 22593651.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3351217
  • [Keywords] NOTNLM ; Mahmood grading system / WHO grading system / brain tumor / intracranial / intraspinal / meningioma
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68. Noël G, Bollet MA, Calugaru V, Feuvret L, Haie-Meder C, Dhermain F, Ferrand R, Boisserie G, Beaudré A, Mazeron JJ, Habrand JL: Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. Int J Radiat Oncol Biol Phys; 2005 Aug 1;62(5):1412-22
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  • [Title] Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons.
  • PURPOSE: To evaluate efficacy and tolerance of external fractionated combination of photon and proton radiation therapy (RT) for intracranial benign meningiomas.
  • METHODS AND MATERIALS: Between 1994 and 2002, 51 patients with intracranial meningiomas of the base of the skull were treated with a combination of photon and proton RT.
  • Stabilization of the tumor was observed in 38 cases (72%), volume reduction in 10 cases (20%), and intratumor necrosis in 3 cases.
  • [MeSH-major] Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy. Photons / therapeutic use. Protons / therapeutic use. Radiotherapy, Conformal / methods. Visual Acuity

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  • (PMID = 16029801.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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69. Balaji R, Ramachandran K: Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint. Childs Nerv Syst; 2009 Apr;25(4):497-501
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  • PURPOSE: Desmoplastic infantile gangliogliomas (DIG) are rare benign intracranial neoplasms of early childhood with involvement of superficial cerebral cortex and leptomeninges.
  • The purpose of the study was to determine the alterations in metabolite ratios occurring in the neoplasm and combine with magnetic resonance (MR) imaging features to narrow down the diagnosis.
  • Single-voxel short TE (1)H MR spectroscopy was used to study the changes in metabolite ratios in the tumor.
  • RESULTS: Comparison of metabolite ratios between normal brain tissue and tumor-affected region showed lower N-acetyl aspartate to creatine (Cr; 1.58 vs.1.28), higher choline to Cr (0.82 vs.2.03), and no significant change in myo-inositol to Cr (0.42 vs.0.39).
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / metabolism. Ganglioglioma / diagnosis. Ganglioglioma / metabolism

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  • (PMID = 19139903.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 30KYC7MIAI / Aspartic Acid; 4L6452S749 / Inositol; 997-55-7 / N-acetylaspartate; MU72812GK0 / Creatine; N91BDP6H0X / Choline
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70. Higashida T, Sakata K, Kanno H, Tanabe Y, Kawasaki T, Yamamoto I: [Intracranial chondroma arising from the skull base: two case reports featuring the image findings for differential diagnosis]. No Shinkei Geka; 2007 May;35(5):495-501
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  • [Title] [Intracranial chondroma arising from the skull base: two case reports featuring the image findings for differential diagnosis].
  • We reported two cases of intracranial skull base chondroma and discussed the differential diagnosis and the treatment strategies.
  • MRI showed a huge tumor occupying the bilateral cavernous sinus.
  • Partial removal of the tumor was performed through the left orbitozygomatic subtemporal approach.
  • MRI showed a brain stem infarction with a huge tumor located at the right middle fossa.
  • In these two cases, the histopathological diagnosis of the tumors was benign chondroma and the size of residual tumors have not changed for one year without any additional therapy.
  • [MeSH-major] Chondroma / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 17491346.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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71. Korcum AF, Ağirdir BV, Aksu G, Güney K, Dinç O: [Treatment modalities of nasopharyngeal angiofibroma]. Kulak Burun Bogaz Ihtis Derg; 2008 Jul-Aug;18(4):263-7
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  • Nasopharyngeal angiofibroma is a rare, benign vascular tumor originating from the sphenopalatine foramen.
  • Due to its propensity to locally destructive growth, the tumor may lead to fatal epistaxis, intracranial extension, and life-threatening complications such as intraoperative hemorrhage.
  • [MeSH-major] Angiofibroma / radiotherapy. Angiofibroma / surgery. Nasopharyngeal Neoplasms / radiotherapy. Nasopharyngeal Neoplasms / surgery

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  • (PMID = 19052499.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 39
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72. Pascual-Castroviejo I, Pascual-Pascual SI, Velazquez-Fragua R, García-Guereta L, López-Gutiérrez JC, Olivares P, Tovar J: Association of cutaneous red-to-purple hemangiomas with leptomeningeal hemangiomas. a clinical study of two patients. Neuropediatrics; 2010 Feb;41(1):7-11
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  • Cutaneous hemangioma is a benign vascular tumor of infancy with an initial proliferating period that appears between 1 to 2 weeks of life, extends during 18 months to 2 years of life, and then slowly regresses during several years until it disappears completely.
  • Cutaneous hemangiomas can be associated with intracranial or extracranial hemangiomas that regress at the same time as the cutaneous hemangiomas.
  • The intracranial angiographic studies in our series of more than 50 cases with facial hemangioma showed that patients with red-to-purple hemangiomas are commonly associated with localized leptomeningeal hemangiomas either in the ipsilateral or contralateral side.
  • [MeSH-major] Hemangioma. Meningeal Neoplasms. Skin Diseases, Vascular. Skin Neoplasms

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  • (PMID = 20571984.001).
  • [ISSN] 1439-1899
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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73. Hackman T, Snyderman CH, Carrau R, Vescan A, Kassam A: Juvenile nasopharyngeal angiofibroma: The expanded endonasal approach. Am J Rhinol Allergy; 2009 Jan-Feb;23(1):95-9
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  • BACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) is a benign but locally aggressively vascular tumor that may involve the skull base and extend intracranially.
  • We reviewed our experience managing JNA, specifically with respect to utility of the expanded endonasal approach (EEA) for lesions with skull base and intracranial extension.
  • METHODS: All cases of JNA at the University of Pittsburgh Medical Center from 1995 to 2006 were reviewed with respect to tumor size and location, vascular supply and results of embolization, skull base involvement and intracranial extension, surgical approach, blood loss, intraoperative and postoperative complications, and recurrence.
  • Surgical excision of some tumors with intracranial blood supply was staged.
  • Recurrence rates were not associated with extent of tumor or surgical technique.
  • CONCLUSION: Most JNA, regardless of tumor extent, may be completely excised using EEA alone or in combination with minor sublabial incisions avoiding the morbidity associated with larger open approaches or postoperative radiation therapy.
  • [MeSH-major] Angiofibroma / surgery. Endoscopy / methods. Nasopharyngeal Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods

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  • (PMID = 19379621.001).
  • [ISSN] 1945-8924
  • [Journal-full-title] American journal of rhinology & allergy
  • [ISO-abbreviation] Am J Rhinol Allergy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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74. Berne JP, Bouchot O, Jazayeri S, Tatou E, Gomez-Bielfeld MC, Martin L, Brenot R, David M: [Cardiac papillary fibroelastoma, a rare valvular source of cerebral embolism: report of two cases]. Ann Cardiol Angeiol (Paris); 2009 Feb;58(1):61-3
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  • Cardiac papillary fibroelastomas are very rare and benign tumors, usually involving heart valves.
  • The only curative treatment consists of the excision of the tumor under cardiopulmonary bypass.
  • [MeSH-major] Aortic Valve. Endocardial Fibroelastosis / complications. Heart Neoplasms / complications. Intracranial Embolism / etiology. Mitral Valve. Papillary Muscles

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  • (PMID = 18980749.001).
  • [ISSN] 1768-3181
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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75. Popovic MB, Diezi M, Kuchler H, Abouzeid H, Maeder P, Balmer A, Munier FL: Trilateral retinoblastoma with suprasellar tumor and associated pineal cyst. J Pediatr Hematol Oncol; 2007 Jan;29(1):53-6
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  • [Title] Trilateral retinoblastoma with suprasellar tumor and associated pineal cyst.
  • Trilateral retinoblastoma (TRb) is a well-known syndrome associating hereditary retinoblastoma (Rb) with an intracranial neuroblastic tumor arising usually in the pineal region, rarely at the suprasellar or parasellar site.
  • Pineal cysts have recently been reported as a benign variant of TRb.
  • We report the unusual presentation of a TRb in a 12-month-old boy with extensive bilateral Rb, a voluminous suprasellar tumor, pineal cyst, and leptomeningeal disease.
  • [MeSH-major] Central Nervous System Cysts / radiography. Eye Neoplasms / radiography. Meningeal Neoplasms / radiography. Pineal Gland / radiography. Retinoblastoma / radiography


76. Onal C, Yuksel O, Topkan E, Pehlivan B: Bilateral glomus tumor treated with PET-CT based conformal radiotherapy: a case report. Cases J; 2009;2:8402
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  • [Title] Bilateral glomus tumor treated with PET-CT based conformal radiotherapy: a case report.
  • INTRODUCTION: Glomus tumors are benign, slow growing tumors originating from paraganglionic tissue, mostly located at the carotid bifurcation, jugular foramen, cervical portion vagus nerve, and middle ear cavity.
  • Radiotherapy is treatment of choice for patients with intracranial extension, and patients with bilateral and multiple tumors, or patients who are inoperable.
  • CASE PRESENTATION: We present a 53-year-old female patient with a glomus tumor treated with positron emission tomography computed tomography planning and 3D conformal radiotherapy, and the patient has remained free of disease progression 2 years after.
  • CONCLUSION: It is suggested that radiotherapy is a good treatment modality in patients with glomus tumor, and metabolic imaging and treatment planning with positron emission tomography computed tomography is superior to other imaging modalities.

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  • (PMID = 19918426.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769436
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77. Ramírez-Moreno JM, Ortega-Martínez M, Fernández-Gil MA, Bernal-García LM, Bejarano-Moguel V, Fernández-Portales I, Gómez-Baquero MJ, Cabezudo-Artero JM: [Isolated mesencephalic stroke related to a ruptured intracranial dermoid cyst]. Neurocirugia (Astur); 2009 Jun;20(3):272-7
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  • [Title] [Isolated mesencephalic stroke related to a ruptured intracranial dermoid cyst].
  • Dermoids cysts are embrionary benign lesions that comprise approximately 0.04-0.25% of all intracranial tumors.
  • Debut of this type of tumor as acute stroke is poorly reflected in literature.
  • [MeSH-major] Brain Neoplasms. Dermoid Cyst. Mesencephalon / pathology. Stroke

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  • (PMID = 19575132.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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78. Koçak H, Ozyazicioğlu A, Gündoğdu C, Sevimli S: Cardiac hemangioma complicated with cerebral and coronary embolization. Heart Vessels; 2005 Nov;20(6):296-7
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  • Cardiac hemangiomas are rare, benign vascular tumors of the heart.
  • Histopathological examination revealed that the tumor was a hemangioma.
  • [MeSH-major] Heart Neoplasms / complications. Heart Ventricles / surgery. Hemangioma / complications. Intracranial Embolism / etiology. Myocardial Infarction / etiology. Thrombosis / etiology


79. Mahore A, Chagla A, Goel A: Seeding metastases of a benign intraventricular meningioma along the surgical track. J Clin Neurosci; 2010 Feb;17(2):253-5
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  • [Title] Seeding metastases of a benign intraventricular meningioma along the surgical track.
  • Seeding metastases of a benign intraventricular meningioma along the surgical track is rare.
  • We report a patient with a benign fibroblastic intraventricular meningioma that had spread along the path of previous surgery; the recurrences as well as the primary tumor were benign.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Lateral Ventricles / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Metastasis / pathology. Neoplasm Seeding
  • [MeSH-minor] Contrast Media. Headache / etiology. Humans. Iatrogenic Disease / prevention & control. Intracranial Hypertension / etiology. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / physiopathology. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Radiotherapy. Treatment Outcome. Ventriculostomy / adverse effects. Ventriculostomy / methods. Vomiting / etiology

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20036547.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Contrast Media
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80. Gerszten PC, Burton SA: Clinical assessment of stereotactic IGRT: spinal radiosurgery. Med Dosim; 2008;33(2):107-16
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  • The role of stereotactic radiosurgery for the treatment of intracranial lesions is well established.
  • At our institution, we have developed a successful multidisciplinary spinal radiosurgery program in which 542 spinal lesions (486 malignant and 56 benign lesions) were treated with a single-fraction radiosurgery technique.
  • The most common benign tumors were neurofibroma (24 cases), schwannoma (13 cases), and meningioma (7 cases).
  • Tumor volume ranged from 0.16 to 298 mL (mean 47 mL).
  • The primary indication for radiosurgery was pain in 326 cases, as a primary treatment modality in 70 cases, for tumor radiographic tumor progression in 65 cases, for post-surgical treatment in 38 cases, for progressive neurological deficit in 35 cases, and as a radiation boost in 8 cases.
  • Long-term tumor control was demonstrated in 90% of lesions treated with radiosurgery as a primary treatment modality and in 88% of lesions treated for radiographic tumor progression.
  • This technique offers a new therapeutic modality for the primary treatment of a variety of spinal lesions, including the treatment of neoplasms in medically inoperable patients, previously irradiated sites, for lesions not amenable to open surgical techniques, and as an adjunct to surgery.
  • [MeSH-major] Radiography, Interventional. Radiosurgery / methods. Spinal Neoplasms / surgery

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  • (PMID = 18456162.001).
  • [ISSN] 0958-3947
  • [Journal-full-title] Medical dosimetry : official journal of the American Association of Medical Dosimetrists
  • [ISO-abbreviation] Med Dosim
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Sakowitz OW, Harting I, Kohlhof P, Unterberg AW, Steiner HH: Acute haemorrhage into a microcystic meningioma leading to cerebral herniation. Br J Neurosurg; 2005 Jun;19(3):260-4
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  • Low-grade (WHO level I) meningiomas are slow-growing, benign tumours typically presenting with unspecific symptoms (e.g. headache), seizures, cranial nerve compression and neuropsychological symptoms determined by location and size of the lesion.
  • ITH has been described in all including benign intracranial neoplasms.
  • [MeSH-major] Encephalocele / etiology. Intracranial Hemorrhages / complications. Meningeal Neoplasms / complications. Meningioma / complications

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  • (PMID = 16455530.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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82. Feigin E, Abir R, Fisch B, Kravarusic D, Steinberg R, Nitke S, Avrahami G, Ben-Haroush A, Freud E: Laparoscopic ovarian tissue preservation in young patients at risk for ovarian failure as a result of chemotherapy/irradiation for primary malignancy. J Pediatr Surg; 2007 May;42(5):862-4
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  • RESULTS: The study group included 23 patients (median age = 14 years) with various types of cancer (hematologic, bone, ovarian, or intracranial); 11 patients were scheduled for chemotherapy, 11 patients had already undergone some form of chemotherapy before the ovarian tissue harvesting, and 1 patient was not scheduled for chemotherapy.
  • In the other 2 patients, the ovary was preserved during inguinal hernia repair or tissue was obtained at laparotomy for a pelvic tumor.
  • All patients had benign operative and postoperative courses.
  • [MeSH-major] Cryopreservation. Fertility. Laparoscopy / methods. Ovarian Neoplasms. Ovary / transplantation. Primary Ovarian Insufficiency / etiology. Primary Ovarian Insufficiency / therapy. Tissue Transplantation / methods

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  • (PMID = 17502200.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Bouvier C, Liprandi A, Colin C, Giorgi R, Quilichini B, Metellus P, Figarella-Branger D: Lack of alkaline phosphatase activity predicts meningioma recurrence. Am J Clin Pathol; 2005 Aug;124(2):252-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Meningiomas usually are benign intracranial tumors.
  • [MeSH-major] Alkaline Phosphatase / biosynthesis. Biomarkers, Tumor / analysis. Meningeal Neoplasms / enzymology. Meningioma / enzymology. Neoplasm Recurrence, Local / enzymology

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  • (PMID = 16040297.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.1.3.1 / Alkaline Phosphatase
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84. Vandeva S, Tichomirowa MA, Zacharieva S, Daly AF, Beckers A: Genetic factors in the development of pituitary adenomas. Endocr Dev; 2010;17:121-33
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  • Pituitary adenomas are one of the most frequent intracranial tumors.
  • Usually, they are benign but are of great clinical significance because of tumor compression syndrome and hormone overproduction.
  • Newer genes associated pituitary tumor development include CDKN1B (MEN4) and AIP, the latter of which is involved in the pathophysiology of 15% of FIPA kindreds.
  • Furthermore, there is not a well established relationship between the genotype and its influence on the protein expression, ligand-receptor interaction, tumor growth or hormone hyperproduction.
  • [MeSH-major] Adenoma / genetics. Pituitary Neoplasms / genetics

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 19955762.001).
  • [ISSN] 1662-2979
  • [Journal-full-title] Endocrine development
  • [ISO-abbreviation] Endocr Dev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cell Cycle Proteins
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85. Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S: Teratomas in central nervous system: a clinico-morphological study with review of literature. Neurol India; 2010 Nov-Dec;58(6):841-6
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  • Histopathology is diagnostic; most of the lesions are benign.
  • Of these, 11 were mature cystic teratomas; and 1 case each, of teratoma with malignant transformation, terato-carcinoma and mixed germ cell tumor (immature teratoma with germinoma).
  • Six of the 14 cases were intracranial and 8 were spinal.
  • Radiologically, contrast enhancement with predominantly solid component was suggestive of malignancy or an aggressive tumor.
  • Excision was curative or provided symptomatic relief in most cases; terato-carcinoma and mixed germ cell tumor patients needed adjuvant radiotherapy.
  • [MeSH-major] Central Nervous System Neoplasms / diagnosis. Central Nervous System Neoplasms / surgery. Teratoma / diagnosis. Teratoma / surgery

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  • (PMID = 21150046.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
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86. Coluccia D, Fandino J, Fujioka M, Cordovi S, Muroi C, Landolt H: Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas. Acta Neurochir (Wien); 2010 Oct;152(10):1711-9
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  • METHODS: A total of 33 consecutive patients undergoing resection of intracranial meningiomas from December 2007 to August 2009 were included in this study.
  • Intraoperative 440 nm fluorescence was applied periodically during and at the end of resection in order to detect tumor-infiltrated sites.
  • The fluorescence of the tumor was evaluated intraoperatively by the surgeon and confirmed by subsequent video analysis.
  • RESULTS: A total of 32 (97%) patients presented with benign meningiomas (WHO I-II).
  • 5-ALA-induced fluorescence of the tumor was confirmed in a total of 31 (94%) patients.
  • [MeSH-major] Aminolevulinic Acid. Fluorescence. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Monitoring, Intraoperative / methods. Photosensitizing Agents
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness / diagnosis. Neoplasm Recurrence, Local / prevention & control. Preoperative Care / methods. Ultraviolet Rays

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  • (PMID = 20535506.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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87. Sawada K, Maehara T, Inaji M, Toriyama H, Okada T, Nariai T, Aoyagi M, Doi M, Ohno K: [Case of ruptured multiple cerebral aneurysms associated with primary aldosteronism]. No Shinkei Geka; 2010 Apr;38(4):347-51
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  • Primary aldosteronism (PA) has been recognized as a relatively benign form of hypertension associated with a low incidence of vascular complications.
  • She was diagnosed with PA on the basis of elevated plasma aldosterone, suppressed plasma rennin, and a right adrenal tumor detected by abdominal CT scanning.
  • We also recommend screening for intracranial aneurysms by low-invasive magnetic resonance angiography.
  • [MeSH-major] Aneurysm, Ruptured / etiology. Aneurysm, Ruptured / surgery. Hyperaldosteronism / complications. Intracranial Aneurysm / etiology. Intracranial Aneurysm / surgery. Subarachnoid Hemorrhage / etiology
  • [MeSH-minor] Adenoma / complications. Adenoma / surgery. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Female. Humans. Middle Aged. Vascular Surgical Procedures

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  • (PMID = 20387576.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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88. Ochalski PG, Edinger JT, Horowitz MB, Stetler WR, Murdoch GH, Kassam AB, Engh JA: Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. J Neurosurg; 2010 May;112(5):978-82
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  • [Title] Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults.
  • The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis.
  • To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease).
  • This is the second report of primary intracranial AFH.
  • Additionally, hemorrhage from an intracranial AFH lesion has yet to be reported, and little is known about the radiographic characteristics and biological behavior of these lesions.
  • In this report, the authors describe the case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH.
  • Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern.
  • [MeSH-major] Angiomatosis / complications. Angiomatosis / pathology. Cerebral Hemorrhage / complications. Cerebral Hemorrhage / pathology. Histiocytoma, Benign Fibrous / complications. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 19731989.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Siniscalchi EN, Angileri FF, Mastellone P, Catalfamo L, Giusa M, Conti A, De Ponte FS, Tomasello F: Anterior skull base reconstruction with a galeal-pericranial flap. J Craniofac Surg; 2007 May;18(3):622-5
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  • Excision of neoplasm and trauma involving the anterior cranial base may often result in communication between the intracranial and extracranial compartments.
  • Ten underwent a combined maxillofacial-neurosurgical approach for the removal of a benign tumor involving the anterior skull base.
  • [MeSH-minor] Adult. Craniocerebral Trauma / surgery. Craniotomy. Facial Injuries / surgery. Female. Fibrin Tissue Adhesive / therapeutic use. Follow-Up Studies. Graft Survival. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications. Retrospective Studies. Skull Base Neoplasms / surgery. Subdural Effusion / surgery. Tissue Adhesives / therapeutic use. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17538328.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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90. Ulfarsson E, Karström A, Yin S, Girnita A, Vasilcanu D, Thoren M, Kratz G, Hillman J, Axelson M, Larsson O, Girnita L: Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. Clin Cancer Res; 2005 Jul 1;11(13):4674-80
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  • Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children.
  • Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology. Receptor, IGF Type 1 / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Cell Proliferation / drug effects. Child. Dose-Response Relationship, Drug. Humans. Immunohistochemistry. Inhibitory Concentration 50. Insulin-Like Growth Factor I / pharmacology. Middle Aged. Phosphorylation / drug effects. Podophyllotoxin / analogs & derivatives. Podophyllotoxin / pharmacology. Tumor Cells, Cultured

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  • (PMID = 16000560.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0F35AOI227 / picropodophyllin; 67763-96-6 / Insulin-Like Growth Factor I; EC 2.7.10.1 / Receptor, IGF Type 1; L36H50F353 / Podophyllotoxin
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91. Agaoglu FY, Ayan I, Dizdar Y, Kebudi R, Gorgun O, Darendeliler E: Ependymal tumors in childhood. Pediatr Blood Cancer; 2005 Sep;45(3):298-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ependymal tumors are classified as ependymoma (benign or low grade) versus anaplastic ependymoma (malignant or high grade).
  • Ependymomas represent 5-10% of intracranial neoplasm in children.
  • Total tumor resection was performed in 20 patients (50%), subtotal in 18 patients (45%), and biopsy only in 2 patients (5%).
  • CONCLUSIONS: The majority of complete responders were patients who had total tumor removal.
  • [MeSH-major] Brain Neoplasms. Ependymoma

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  • [Copyright] (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15770637.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Erdoğan E, Cansever T: Transcallosal transbiforaminal approach to the third ventricle. Turk Neurosurg; 2009 Apr;19(2):192-6
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  • BACKGROUND: Colloid cysts are benign intracranial lesions but can show signs of severe obstructive hydrocephalus and present with sudden death.
  • Tumor control can be achieved with the biforaminal approach but the tumor excision should be performed from the right foramen due left side forniceal memory dominance.
  • Safer and harmless excision can be achieved with the transbiforaminal approach if the tumor excision is performed from the right foramen.

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  • (PMID = 19431135.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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93. Gabeau-Lacet D, Grant E, Stemmer-Rachamimov A, Yock T, Tarbell NJ: Sellar abnormalities in female first-degree relatives. Clin Neurol Neurosurg; 2008 Feb;110(2):202-6
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  • Each of these cases was diagnosed and managed differently, illustrating the relative importance of radiographic imaging, tumor markers and histopathologic examination in the diagnosis and treatment of intracranial disease.
  • One daughter was treated presumptively for germinoma based on characteristic radiographic studies and slightly elevated tumor marker.
  • The other daughter's lesion exhibited radiographic characteristics concerning for pituitary macroadenoma but with slightly elevated germ cell tumor marker, raising the suspicion for germinoma.
  • Biopsy of the intrasellar mass revealed only proteinaceous material and normal anterior pituitary, consistent with cyst content without evidence of neoplasm.
  • At least two of the patients had benign cysts.
  • [MeSH-major] Central Nervous System Cysts / genetics. Central Nervous System Cysts / pathology. Pituitary Neoplasms / genetics. Pituitary Neoplasms / pathology

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  • (PMID = 18035480.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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94. Arsene D, Georgescu A, Dănăilă L, Ardeleanu C: Giant intracranial endolymphatic sac tumor (ELST). Case presentation and histogenetic considerations. Rom J Morphol Embryol; 2008;49(1):85-90
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  • [Title] Giant intracranial endolymphatic sac tumor (ELST). Case presentation and histogenetic considerations.
  • We present a giant tumor of the skull base compressing the brain in a 40-years-old man.
  • The tumor was policystic at imaging.
  • Its histopathology, immunohistochemical profile and long evolution suggest an endolymphatic sac tumor (ELST), a rare case of neoplasia.
  • This could be from either the organ of Corti or some local cells that generate a resemblance with a systemic tumor, the so-called benign mesothelioma.
  • [MeSH-major] Endolymphatic Sac / metabolism. Endolymphatic Sac / pathology. Meningioma / metabolism. Meningioma / pathology. Skull Base Neoplasms / metabolism. Skull Base Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Humans. Male. Tumor Burden

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  • (PMID = 18273509.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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95. Jolapara M, Kesavadas C, Radhakrishnan VV, Thomas B, Gupta AK, Bodhey N, Patro S, Saini J, George U, Sarma PS: Role of diffusion tensor imaging in differentiating subtypes of meningiomas. J Neuroradiol; 2010 Dec;37(5):277-83
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  • PURPOSE: Meningiomas are the most common extraaxial intracranial type of tumor, and their management and prognosis depend on their grade and histology.
  • METHODS AND MATERIALS: A total of 21 consecutive patients with meningioma were included in this retrospective study, of whom 16 had benign meningiomas (three fibroblastic, 11 transitional/mixed, two meningothelial) and five had atypical meningiomas.
  • Tumor mean diffusivity (Dav), fractional anisotropy (FA), linear anisotropy (CL), planar anisotropy (CP), spherical anisotropy (CS) and eigenvalues (e1, e2, e3) were measured in all cases, and differences in diffusion tensor metrics between atypical, fibroblastic and other benign (transitional, meningothelial) meningiomas were statistically analyzed using the Mann-Whitney test.
  • RESULTS: No statistically significant differences were found among the mean Dav values for atypical, fibroblastic and other benign meningiomas.
  • Atypical meningiomas showed higher CL values compared with fibroblastic and other benign meningiomas but, again, the difference was not statistically significant.
  • CONCLUSION: These results suggest that diffusion tensor metrics may be helpful in the differentiation of atypical, fibroblastic and other benign meningiomas.
  • [MeSH-major] Diffusion Tensor Imaging. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20381865.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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96. Yoshikawa G, Kawamoto S, Yakou K, Tsutsumi K: Massive intracranial hemorrhage associated with pleomorphic xanthoastrocytoma--case report. Neurol Med Chir (Tokyo); 2010;50(3):220-3
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  • [Title] Massive intracranial hemorrhage associated with pleomorphic xanthoastrocytoma--case report.
  • A 60-year-old woman with a history of intermittent headaches and frequent seizures for 30 years presented with a massive intracranial hematoma in the left medial temporal lobe with thick subarachnoid hemorrhage.
  • Presumably the bleeding was caused by the rupture of a pseudoaneurysm secondary to leptomeningeal involvement of this typically benign tumor.
  • [MeSH-major] Aneurysm, False / etiology. Aneurysm, Ruptured / etiology. Astrocytoma / complications. Brain Neoplasms / complications. Hematoma, Subdural, Intracranial / etiology. Subarachnoid Hemorrhage / etiology

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  • (PMID = 20339272.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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97. Boviatsis EJ, Bouras TI, Kouyialis AT, Themistocleous MS, Sakas DE: Impact of age on complications and outcome in meningioma surgery. Surg Neurol; 2007 Oct;68(4):407-11; discussion 411
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Surgery for benign brain tumors in elderly patients without severe general health problems is an acceptable practice, as results are comparable with the ones of younger patients.
  • Tumor removal rate was not significantly different in the 2 groups.
  • CONCLUSIONS: Operation for intracranial meningioma in elderly patients is justified as long as detailed preoperative evaluation is performed.
  • [MeSH-major] Meningioma / surgery. Postoperative Complications / epidemiology. Supratentorial Neoplasms / surgery

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  • (PMID = 17586023.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Landau D, Avgeropoulos N, Ma J: Cerebral amyloidoma mimicking intracranial tumor: a case report. J Med Case Rep; 2010;4:308
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebral amyloidoma mimicking intracranial tumor: a case report.
  • CONCLUSION: After discovery of the true etiology of his brain abnormality, it was determined that our patient had a more benign disease than was initially feared.

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  • (PMID = 20854655.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2946306
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99. Yener U, Bayrakli F, Vardereli E, Sav A, Peker S: Intradiploic meningioma mimicking calvarial metastasis: case report. Turk Neurosurg; 2009 Jul;19(3):297-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Meningiomas are the most common benign intracranial neoplasms.
  • Nearly 20% of all primary intracranial tumors are meningiomas.
  • The possibility of an intraosseous meningioma mimicking a metastatic tumor should be kept in mind.
  • [MeSH-major] Meningioma / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Parietal Bone / radionuclide imaging. Skull Neoplasms / radionuclide imaging
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Positron-Emission Tomography. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19621299.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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100. Coutinho-Camillo CM, Brentani MM, Nagai MA: Genetic alterations in juvenile nasopharyngeal angiofibromas. Head Neck; 2008 Mar;30(3):390-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors.
  • Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension.
  • Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial.
  • Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor.
  • [MeSH-major] Angiofibroma / genetics. Nasopharyngeal Neoplasms / genetics

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18228521.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / beta Catenin; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 103
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