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1. Fabi A, Nuzzo C, Vidiri A, Ciccarese M, Felici A, Cattani F, Cognetti F: Bone and lung metastases from intracranial meningioma. Anticancer Res; 2006 Sep-Oct;26(5B):3835-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone and lung metastases from intracranial meningioma.
  • Fifteen percent of intracranial tumors are represented by meningiomas.
  • Meningioma is usually a benign neoplasm; malignant histology is rare and represents about 2-10% with a 43% incidence of metastasis.
  • There are no definitive criteria to predict the recurrence or metastases of meningioma and histological grading, according to WHO criteria, is the most important predictor of malignancy.
  • A rare case of a woman with a relapse of intracranial meningioma in the right frontal lobe who subsequently developed simultaneous bone and intrapulmonary metastases is reported.
  • According to these sites of metastases, it is suggested that in patients with a history of relapsed meningioma, a total body CT scan should be performed in order to investigate other possible sites of disease.
  • [MeSH-major] Bone Neoplasms / secondary. Brain Neoplasms / pathology. Lung Neoplasms / secondary. Meningioma / pathology

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  • (PMID = 17094409.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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2. Bodkin PA, Hassan MF, Kane PJ, Brady N, Whittle IR: 'Surgical' causes of benign intracranial hypertension. J R Soc Med; 2008 May;101(5):259-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 'Surgical' causes of benign intracranial hypertension.
  • Benign intracranial hypertension is a clinical diagnosis linked to a number of medical and surgical disorders.
  • [MeSH-minor] Adolescent. Adult. Ethmoid Sinus. Headache Disorders / etiology. Headache Disorders / surgery. Humans. Magnetic Resonance Angiography. Male. Meningeal Neoplasms / complications. Meningeal Neoplasms / surgery. Meningioma / complications. Meningioma / surgery. Middle Aged. Skull Fracture, Depressed / complications. Skull Fracture, Depressed / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18463282.001).
  • [ISSN] 0141-0768
  • [Journal-full-title] Journal of the Royal Society of Medicine
  • [ISO-abbreviation] J R Soc Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2376264
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3. Mittal A, Layton KF, Finn SS, Snipes GJ, Opatowsky MJ: Cystic meningioma: unusual imaging appearance of a common intracranial tumor. Proc (Bayl Univ Med Cent); 2010 Oct;23(4):429-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic meningioma: unusual imaging appearance of a common intracranial tumor.
  • Meningiomas are common tumors of the central nervous system that account for approximately 15% of all intracranial tumors and are the most common extra-axial neoplasm.
  • Most meningiomas are benign, although atypical and malignant meningiomas also exist.
  • We present a case of a woman who presented with a history of multiple recent falls, decreased energy, and increased somnolence and was found to have a "cystic meningioma."

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  • (PMID = 21240328.001).
  • [ISSN] 1525-3252
  • [Journal-full-title] Proceedings (Baylor University. Medical Center)
  • [ISO-abbreviation] Proc (Bayl Univ Med Cent)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2943459
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4. Wiemels J, Wrensch M, Claus EB: Epidemiology and etiology of meningioma. J Neurooncol; 2010 Sep;99(3):307-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology and etiology of meningioma.
  • Although most meningiomas are encapsulated and benign tumors with limited numbers of genetic aberrations, their intracranial location often leads to serious and potentially lethal consequences.
  • Inherited susceptibility to meningioma is suggested both by family history and candidate gene studies in DNA repair genes.
  • People with certain mutations in the neurofibromatosis gene (NF2) have a very substantial increased risk for meningioma.
  • High dose ionizing radiation exposure is an established risk factor for meningioma, and lower doses may also increase risk, but which types and doses are controversial or understudied.
  • The extent to which immunologic factors influence meningioma etiology has been largely unexplored.
  • Growing emphasis on brain tumor research coupled with the advent of new genetic and molecular epidemiologic tools in genetic and molecular epidemiology promise hope for advancing knowledge about the causes of intra-cranial meningioma.
  • In this review, we highlight current knowledge about meningioma epidemiology and etiology and suggest future research directions.

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  • (PMID = 20821343.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA109468; United States / NCI NIH HHS / CA / R01 CA109745-05; United States / NCI NIH HHS / CA / R01 CA109745-04; United States / NCI NIH HHS / CA / CA109745; United States / NCI NIH HHS / CA / CA52689; United States / NCI NIH HHS / CA / R01 CA109468; United States / NCI NIH HHS / CA / R01 CA109745-03; United States / NCI NIH HHS / CA / CA109461; United States / NCI NIH HHS / CA / R01 CA151933; United States / NCI NIH HHS / CA / P50 CA097257; United States / NCI NIH HHS / CA / CA108473; United States / NCI NIH HHS / CA / CA097257; United States / NCI NIH HHS / CA / R01 CA109461; United States / NCI NIH HHS / CA / R01 CA109745-02; United States / NCI NIH HHS / CA / R01 CA109475; United States / NCI NIH HHS / CA / R01 CA109745; United States / NCI NIH HHS / CA / CA109475; United States / NCI NIH HHS / CA / R01 CA052689
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2945461
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5. Püttmann S, Senner V, Braune S, Hillmann B, Exeler R, Rickert CH, Paulus W: Establishment of a benign meningioma cell line by hTERT-mediated immortalization. Lab Invest; 2005 Sep;85(9):1163-71
Cellosaurus - a cell line knowledge resource. culture/stock collections - Ben-Men-1 (CVCL_1959) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment of a benign meningioma cell line by hTERT-mediated immortalization.
  • Meningioma represents the most common intracranial tumor, but well-characterized cell lines derived from benign meningiomas are not available.
  • A major reason for the lack of benign tumor cell lines is senescence of nonmalignant cells in vitro, while malignant cells are often immortal.
  • We have developed a meningioma cell line by retrovirally transducing primary cells derived from a human WHO grade I meningothelial meningioma with the human telomerase reverse transcriptase (hTERT) gene, which enables bypassing cellular senescence.
  • One clone, designated Ben-Men-1, was characterized in more detail, and exhibited typical cytological, immunocytochemical, ultrastructural and genetical features of meningioma, including whorl formation, expression of epithelial membrane antigen, desmosomes and interdigitating cell processes, as well as -22q.
  • Following subdural transplantation into nude mice, tumor tissue with typical histological features of meningothelial meningioma was found.
  • We conclude that Ben-Men-1 represents an immortalized yet differentiated cell line useful for biological and therapeutical studies on meningioma.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. DNA-Binding Proteins / genetics. Meningioma / pathology. Telomerase / genetics

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  • (PMID = 15965488.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; EC 2.7.7.49 / Telomerase
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6. Vranic A: Antigen expression on recurrent meningioma cells. Radiol Oncol; 2010 Jun;44(2):107-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antigen expression on recurrent meningioma cells.
  • INTRODUCTION: Meningiomas are intracranial brain tumours that frequently recur.
  • Recurrence rates up to 20% in 20 years for benign meningiomas, up to 80% for atypical meningiomas and up to 100% for malignant meningiomas, have been reported.
  • The most important prognostic factors for meningioma recurrence are meningioma grade, meningioma invasiveness and radicality of neurosurgical resection.
  • The aim of our study was to evaluate the differences in antigenic expression on the surface of meningioma cells between recurrent and non-recurrent meningiomas.
  • RESULTS: MIB-1 antigen expression was higher in the recurrent meningioma group (p=0.001).
  • Immunohistochemical intensity scores for cathepsin B (p= 0.007) and cathepsin L (p<0.001) were both higher in the recurrent than in the non-recurrent meningioma group.

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  • (PMID = 22933900.001).
  • [ISSN] 1318-2099
  • [Journal-full-title] Radiology and oncology
  • [ISO-abbreviation] Radiol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovenia
  • [Other-IDs] NLM/ PMC3423683
  • [Keywords] NOTNLM ; cathepsin B / cathepsin L / meningioma / proliferation index, MIB-1 antigen / recurrence / tumour markers
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7. Yener U, Bayrakli F, Vardereli E, Sav A, Peker S: Intradiploic meningioma mimicking calvarial metastasis: case report. Turk Neurosurg; 2009 Jul;19(3):297-301
Genetic Alliance. consumer health - Meningioma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intradiploic meningioma mimicking calvarial metastasis: case report.
  • Meningiomas are the most common benign intracranial neoplasms.
  • Nearly 20% of all primary intracranial tumors are meningiomas.
  • Preoperative diagnosis was a metastasis, but histological examination revealed an osteolytic interosseous meningioma.
  • The possibility of an intraosseous meningioma mimicking a metastatic tumor should be kept in mind.
  • [MeSH-major] Meningioma / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Parietal Bone / radionuclide imaging. Skull Neoplasms / radionuclide imaging

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  • (PMID = 19621299.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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8. Shuto T, Inomori S, Fujino H, Nagano H, Hasegawa N, Kakuta Y: Cyst formation following gamma knife surgery for intracranial meningioma. J Neurosurg; 2005 Jan;102(s_supplement):134-139

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyst formation following gamma knife surgery for intracranial meningioma.
  • OBJECT: The authors conducted a study to evaluate the clinical significance of cyst formation or enlargement after gamma knife surgery (GKS) for intracranial benign meningiomas.
  • METHODS: The medical records of 160 patients with 184 tumors were examined for those with follow-up data of more than 2 years among 270 patients who underwent GKS for intracranial meningiomas between February 1992 and November 2001.
  • CONCLUSIONS: New cyst formation following GKS for benign intracranial meningioma is relatively rare; however, both preexisting and newly developed cysts tend to enlarge after GKS and often require surgery.

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  • (PMID = 28306456.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; cyst / gamma knife surgery / meningioma
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9. Shuto T, Inomori S, Fujino H, Nagano H, Hasegawa N, Kakuta Y: Cyst formation following gamma knife surgery for intracranial meningioma. J Neurosurg; 2005 Jan;102 Suppl:134-9
MedlinePlus Health Information. consumer health - Brain Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyst formation following gamma knife surgery for intracranial meningioma.
  • OBJECT: The authors conducted a study to evaluate the clinical significance of cyst formation or enlargement after gamma knife surgery (GKS) for intracranial benign meningiomas.
  • METHODS: The medical records of 160 patients with 184 tumors were examined for those with follow-up data of more than 2 years among 270 patients who underwent GKS for intracranial meningiomas between February 1992 and November 2001.
  • CONCLUSIONS: New cyst formation following GKS for benign intracranial meningioma is relatively rare; however, both preexisting and newly developed cysts tend to enlarge after GKS and often require surgery.
  • [MeSH-major] Brain Diseases / etiology. Brain Diseases / surgery. Cysts / etiology. Cysts / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Postoperative Complications. Radiosurgery / instrumentation

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  • (PMID = 15662796.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E, Vecht C: Meningioma. Crit Rev Oncol Hematol; 2008 Aug;67(2):153-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningioma.
  • Meningiomas are mostly benign tumours originating from the arachnoid cap cells, represent 13-26% of all intracranial tumours.
  • Radiotherapy is currently used in the clinical practice in atypical, malignant or recurrent meningioma at a total dose of 45-60Gy.
  • [MeSH-major] Meningeal Neoplasms / therapy. Meningioma / therapy

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  • (PMID = 18342535.001).
  • [ISSN] 1040-8428
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 184
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11. Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM: Epidemiology of intracranial meningioma. Neurosurgery; 2005 Dec;57(6):1088-95; discussion 1088-95
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology of intracranial meningioma.
  • Meningiomas are the most frequently reported primary intracranial neoplasms, accounting for approximately 25% of all such lesions diagnosed in the United States.
  • Few studies have examined the risk factors associated with a diagnosis of meningioma with two categories of exposure, hormones (both endogenous and exogenous) and radiation, most strongly associated with meningioma risk.
  • Limited data are also available on long-term outcomes for meningioma patients, although it is clear that the disease is associated with significant morbidity and mortality.
  • Recent legislation passed in the United States (The Benign Brain Tumor Cancer Registries Amendment Act [H.R.
  • 5204]) mandates registration of benign brain tumors such as meningioma.
  • The increased emphasis on research dedicated to the study of brain tumors coupled with the advent of new tools in genetic and molecular epidemiology make the current era an ideal time to advance knowledge for intracranial meningioma.
  • This review highlights current knowledge of meningioma epidemiology and new directions for research efforts in this field.

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  • (PMID = 16331155.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R25 CA089017; United States / NCI NIH HHS / CA / 5R25-CA089017-03; United States / NCI NIH HHS / CA / P50-CA097257; United States / NCI NIH HHS / CA / R01-CA52689
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 76
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12. Llauger J, Aixut S, Cañete N, Palmer J, Solà M, Bagué S: Meningioma of the scapula. Skeletal Radiol; 2008 Feb;37(2):169-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningioma of the scapula.
  • Meningiomas account for approximately 15% of all intracranial tumors and are the most common non-glial primary tumors of the central nervous system.
  • Most meningiomas are benign neoplasms with characteristic imaging features.
  • We report on an extremely rare case of primary extradural meningioma that was located in the scapula.
  • To the best of our knowledge, this form of presentation of an extradural meningioma has not been previously described.
  • [MeSH-major] Bone Neoplasms / diagnosis. Meningioma / diagnosis. Scapula / pathology. Scapula / radiography

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  • (PMID = 18030466.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Milker-Zabel S, Zabel A, Schulz-Ertner D, Schlegel W, Wannenmacher M, Debus J: Fractionated stereotactic radiotherapy in patients with benign or atypical intracranial meningioma: long-term experience and prognostic factors. Int J Radiat Oncol Biol Phys; 2005 Mar 1;61(3):809-16
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  • [Title] Fractionated stereotactic radiotherapy in patients with benign or atypical intracranial meningioma: long-term experience and prognostic factors.
  • PURPOSE: To analyze our long-term experience and prognostic factors after fractionated stereotactic radiotherapy (FSRT) in patients with benign or atypical intracranial meningioma.
  • METHODS AND MATERIALS: Between January 1985 and December 2001, 317 patients with a median age of 55.7 years were treated with FSRT for intracranial meningioma.
  • Local tumor failure was significantly greater in patients with WHO Grade 2 meningioma (p <0.002) than in patients with WHO Grade 1 or unknown histologic features.
  • Patients treated for recurrent meningioma showed a trend toward decreased progression-free survival compared with patients treated with primary therapy, after biopsy, or after subtotal resection (p <0.06).
  • Eight patients developed new clinical symptoms, such as reduced vision, trigeminal neuralgia, and intermittent tinnitus located at the side of the irradiated meningioma after FSRT.
  • CONCLUSION: These data have demonstrated that FSRT is an effective and safe treatment modality for local control of meningioma with a low risk of significant late toxicity.
  • We identified the tumor volume, indication for FSRT, and histologic features of the meningioma as statistically significant prognostic factors.
  • [MeSH-major] Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy

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  • (PMID = 15708260.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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14. Pollock BE: Stereotactic radiosurgery of benign intracranial tumors. J Neurooncol; 2009 May;92(3):337-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiosurgery of benign intracranial tumors.
  • Stereotactic radiosurgery is a frequently performed procedure for patients with benign intracranial tumors.
  • Benign tumors are good candidates for radiosurgery because they are generally non-invasive, are well visualized by magnetic resonance imaging, and their slow rate of proliferation makes conventional radiation dose fractionation unnecessary.
  • This chapter will review the indications and results of radiosurgery for patients with intracranial meningiomas, vestibular schwannomas, and pituitary adenomas having single-fraction radiosurgery at the Mayo Clinic since 1990.
  • [MeSH-major] Adenoma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Pituitary Neoplasms / surgery. Radiosurgery

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  • (PMID = 19357960.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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15. Khong SY, Leach J, Greenwood C: Meningioma mimicking puerperal psychosis. Obstet Gynecol; 2007 Feb;109(2 Pt2):515-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningioma mimicking puerperal psychosis.
  • BACKGROUND: Meningiomas are slow-growing benign brain tumors.
  • Meningioma was diagnosed by computed tomography and treated successfully with steroids, anticonvulsant, and craniotomy.
  • Neuroimaging should be performed in the presence of any neurologic abnormality to exclude intracranial lesions such as meningioma.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Psychotic Disorders / etiology. Puerperal Disorders / diagnosis

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  • (PMID = 17267878.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Moradi A, Semnani V, Djam H, Tajodini A, Zali AR, Ghaemi K, Nikzad N, Madani-Civi M: Pathodiagnostic parameters for meningioma grading. J Clin Neurosci; 2008 Dec;15(12):1370-5
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  • [Title] Pathodiagnostic parameters for meningioma grading.
  • Meningiomas are usually slow-growing benign tumors, for which complete removal can be difficult and recurrence is an issue.
  • In this study the relationship between pathodiagnostic parameters, histological grade, and MIB-1 monoclonal antibody expression in meningioma diagnosed over 10 years in Shohada Hospital, Tehran, was assessed.
  • Between January 1997 and December 2006, a total of 4885 intracranial tumors were diagnosed at Shohada Hospital, 378 (7.74%) of which were meningiomas.
  • All slides stained with hematoxylin and eosin were reviewed by two independent pathologists and all the diagnoses reconfirmed; histological anaplasia was classified according to the grading of the WHO Working Group 2000 as benign (Grade I), atypical with incipient signs of anaplasia (Grade II), or overtly anaplastic (Grade III).
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 18819804.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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17. Chahlavi A, Staugaitis SM, Yahya R, Vogelbaum MA: Intracranial collision tumor mimicking an octreotide-SPECT positive and FDG-PET negative meningioma. J Clin Neurosci; 2005 Aug;12(6):720-3
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  • [Title] Intracranial collision tumor mimicking an octreotide-SPECT positive and FDG-PET negative meningioma.
  • OBJECTIVE/IMPORTANCE: Cancer metastasis to a pre-existing intracranial tumor is rare, but several cases have been reported.
  • We report an unusual case of a "collision tumor" consisting of a renal cell carcinoma metastasis to an intracranial meningioma.
  • MRI characteristics of the tumor were consistent with meningioma.
  • On octreotide-SPECT and F-18 fluorodeoxyglucose (FDG)-PET scans, the lesion showed octreotide uptake but did not accumulate FDG, both of which are consistent with a diagnosis of benign meningioma.
  • The intracranial tumor was resected, and subacute subdural blood was found overlying a soft, reddish tumor.
  • Microscopic examination was consistent with renal cell carcinoma with a minor portion consisting of meningioma.
  • CONCLUSION: Collision tumor involving metastatic renal cell carcinoma to an intracranial meningioma is a rare occurrence.
  • A high degree of suspicion of intracranial metastasis should be maintained for patients who have known systemic cancer and are found incidentally to have a dural-based mass lesion.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma / pathology. Kidney Neoplasms / pathology. Meningioma / secondary. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 16115558.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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18. Askoxylakis V, Zabel-du Bois A, Schlegel W, Debus J, Huber P, Milker-Zabel S: Patterns of failure after stereotactic radiotherapy of intracranial meningioma. J Neurooncol; 2010 Jul;98(3):367-72
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  • [Title] Patterns of failure after stereotactic radiotherapy of intracranial meningioma.
  • The aim of this work is to evaluate patterns of failure in patients with recurrent meningioma after stereotactic radiotherapy.
  • Of 411 patients with intracranial meningioma treated with radiotherapy at our institution, 22 patients with local tumor progression diagnosed by magnetic resonance imaging (MRI) after radiotherapy (RT) were identified and further investigated.
  • Median recurrence-free survival was 46 months for patients with benign meningioma (WHO grade I) and 31.5 months for patients with higher-grade meningioma (WHO grade II/III).
  • Median time to local tumor progression and site of local recurrence significantly depended on histological grade of meningioma.
  • Regarding site of failure, improvement of dose coverage for benign meningiomas and dose escalation for high-grade tumors might further improve therapy outcome.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Radiosurgery / methods

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  • (PMID = 20012910.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Mahore A, Chagla A, Goel A: Seeding metastases of a benign intraventricular meningioma along the surgical track. J Clin Neurosci; 2010 Feb;17(2):253-5
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  • [Title] Seeding metastases of a benign intraventricular meningioma along the surgical track.
  • Seeding metastases of a benign intraventricular meningioma along the surgical track is rare.
  • We report a patient with a benign fibroblastic intraventricular meningioma that had spread along the path of previous surgery; the recurrences as well as the primary tumor were benign.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Lateral Ventricles / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Metastasis / pathology. Neoplasm Seeding
  • [MeSH-minor] Contrast Media. Headache / etiology. Humans. Iatrogenic Disease / prevention & control. Intracranial Hypertension / etiology. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / physiopathology. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Radiotherapy. Treatment Outcome. Ventriculostomy / adverse effects. Ventriculostomy / methods. Vomiting / etiology

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20036547.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Contrast Media
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20. Stienen MN, Lücke S, Fournier JY, Hildebrandt G, Gautschi OP: [The intracranial meningioma - therapeutic possibilities and limitations]. Praxis (Bern 1994); 2010 Dec 1;99(24):1479-94
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  • [Title] [The intracranial meningioma - therapeutic possibilities and limitations].
  • Meningiomas are common intracranial tumours that arise from arachnoidal cells.
  • More than 90 percent of these mostly slow growing meningiomas are benign.

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  • (PMID = 21125533.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
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21. Kalamarides M, Peyre M, Giovannini M: Meningioma mouse models. J Neurooncol; 2010 Sep;99(3):325-31
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  • [Title] Meningioma mouse models.
  • Meningiomas, although mostly benign, may sometimes present aggressive features and raise issues concerning alternative treatment options besides surgery.
  • In order to gain new insights in meningioma biology and develop alternative treatments, several meningioma mouse models have been engineered during the past two decades.
  • As rodents very rarely develop spontaneous meningiomas, animal models have been first developed by implanting human meningioma cells derived from a primary tumor and meningioma cell lines subcutaneously into athymic mice.
  • Advances in our understanding of molecular genetics of meningioma have pinpointed the central role of NF2 tumor suppressor gene in the pathogenesis of those tumors.
  • These discoveries have led to the creation of a genetically engineered model utilizing conditional mutagenesis to specifically inactivate the mouse Nf2 gene in arachnoidal cells, resulting in the formation of intracranial meningothelial hyperplasia and meningiomas and thus reproducing the main mechanism of human meningeal tumorigenesis.
  • This powerful new technology significantly improves on prior models and may open avenues of investigation never before possible in meningioma research.
  • We present here a review of current meningioma mouse models used in translational therapeutics with associated imaging and pre-clinical studies.
  • [MeSH-major] Disease Models, Animal. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 20734219.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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22. van der Meij JJ, Boomars KA, van den Bosch JM, van Boven WJ, de Bruin PC, Seldenrijk CA: Primary pulmonary malignant meningioma. Ann Thorac Surg; 2005 Oct;80(4):1523-5
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  • [Title] Primary pulmonary malignant meningioma.
  • Primary pulmonary meningiomas are relatively rare and mostly benign.
  • To exclude pulmonary metastasis of an intracranial meningioma, imaging studies of the brain should be performed.
  • We believe that only one primary pulmonary malignant meningioma in which a metastasis from the brain was excluded has been reported.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / pathology. Meningioma / diagnosis. Meningioma / pathology

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  • (PMID = 16181912.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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23. Cecchi PC, Campello M, Rizzo P, Mair K, Schwarz A: Atypical meningioma of the sylvian fissure. J Clin Neurosci; 2009 Sep;16(9):1234-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical meningioma of the sylvian fissure.
  • Meningiomas are meningothelial cell neoplasms that account for approximately 25% of all primary intracranial tumors.
  • Most meningiomas are slow-growing benign lesions, and they are usually attached to the inner surface of the dura mater.
  • We describe an atypical sylvian fissure meningioma in a 23-year-old male with a brief history of headache and mild hemiparesis.
  • [MeSH-major] Cerebral Cortex / pathology. Meningioma / pathology

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  • (PMID = 19497747.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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24. Ong L, Ferrucci S: Tuberculum sellae meningioma associated with lymphomatoid papulosis. Optometry; 2005 Mar;76(3):165-75
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  • [Title] Tuberculum sellae meningioma associated with lymphomatoid papulosis.
  • We present a case of a tuberculum sellae meningioma concurrent with lymphomatoid papulosis, a T-cell lymphomatoid skin disorder.
  • MRI revealed a meningioma arising from the tuberculum sellae and planum sphenoidale region.
  • The meningioma was partially resected nine days later Visual field performed 18 days postoperatively demonstrated an overall depression in the right eye and no defect in the left eye.
  • CONCLUSION: Meningiomas are generally benign tumors that can cause symptoms if vital structures are compromised.
  • Altered visual function and optic atrophy may be the only presentation of intracranial and orbital tumors.
  • Intracranial meningiomas may be associated with systemic conditions that can infiltrate the optic nerve, including lymphocytic disorders.
  • [MeSH-major] Lymphomatoid Papulosis / complications. Meningeal Neoplasms / complications. Meningioma / complications. Optic Atrophy / etiology. Sella Turcica / pathology. Vision Disorders / etiology

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  • (PMID = 15786635.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Alexiou GA, Vartholomatos G, Tsiouris S, Papadopoulos A, Kyritsis AP, Polyzoidis KS, Voulgaris S, Fotopoulos AD: Evaluation of meningioma aggressiveness by (99m)Tc-Tetrofosmin SPECT. Clin Neurol Neurosurg; 2008 Jul;110(7):645-8
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  • [Title] Evaluation of meningioma aggressiveness by (99m)Tc-Tetrofosmin SPECT.
  • OBJECTIVES: Although meningiomas usually have a benign clinical course, atypical and malignant types of this brain tumor are associated with high recurrence rates and poor outcome; thus, DNA ploidy and S-phase -- as determined by DNA flow cytometry -- are useful indicators of their biological behavior.
  • This study evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with meningioma proliferative activity, as assessed by flow cytometry analysis.
  • PATIENTS AND METHODS: Ten consecutive patients (3 males, 7 females, mean age 64.6 years) with a diagnosis of a symptomatic intracranial meningioma, planned to undergo surgery, were studied.
  • RESULTS: Benign meningiomas were diagnosed in 8/10 cases, the remaining 2/10 patients had anaplastic lesions.
  • CONCLUSION: These results imply that (99m)Tc-TF brain SPECT may have the ability to discriminate benign meningiomas from malignant meningiomas pre-operatively, the tracer uptake being a likely indicator of their proliferative activity.
  • [MeSH-major] Meningeal Neoplasms / radionuclide imaging. Meningioma / radionuclide imaging. Organophosphorus Compounds. Organotechnetium Compounds. Tomography, Emission-Computed, Single-Photon / methods

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  • (PMID = 18471956.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
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26. Velnar T, Bunc G: Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. Wien Klin Wochenschr; 2008;120(23-24):766-9
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  • [Title] Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report.
  • As far as we know, the presented case is the first report in the literature of iatrogenic seeding of a benign meningioma to the scalp following surgery.
  • A 37-year-old woman was admitted because of a relapsing meningioma in the frontal lobe.
  • In 1997, she had undergone complete excision of an atypical meningioma in same location.
  • At follow-up, three new masses were found: a bifrontal meningioma on the edge of the falx, a smaller one in the falx just under the saggital sinus and a small mass, believed to be ectopic, in the periosteum at the site of the previous craniotomy.
  • Histologically, the ectopic tumor was an atypical meningioma, similar to the one excised 10 years previously, with no relation to the other two intracranial masses.
  • The authors suggest that strict adherence to oncological principles should be applied in the case of benign neoplasms in order to prevent contamination of wounds with tumor cells and potential recurrence.
  • [MeSH-major] Craniotomy. Meningeal Neoplasms / surgery. Meningioma / secondary. Meningioma / surgery. Neoplasm Seeding. Neoplasms, Multiple Primary / surgery. Periosteum. Skull Neoplasms / secondary

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  • (PMID = 19122989.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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27. Russo N, Giangaspero F, Beccaglia MR, Santoro A: Intracranial dural histiocytosis. Br J Neurosurg; 2009 Aug;23(4):449-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial dural histiocytosis.
  • Rosai-Dorfman disease is a common benign lymphomatous disorder that involves the lymph nodes and other solid organs.
  • Neurological involvement is rare, and an isolated intracranial Rosai-Dorfman lesion even rarer.
  • Whether isolated intracranial Rosai-Dorfman lesions should be defined as Rosai-Dorfman disease or intradural histiocytosis remains debatable.
  • Although these intracranial masses may radiologically mimic a meningioma, some have diagnostically specific radiological appearances.
  • Because isolated intracranial Rosai-Dorfman lesions are so rarely described their best treatment is controversial.
  • Our two case reports, a patient with isolated dural intracranial Rosai-Dorfman lesions and another with multiple intracranial lesions, both without lymphadenopathy, should be of interest to neuroradiologists and neurosurgeons managing similar cases.
  • [MeSH-minor] Aged. Craniotomy. Diagnosis, Differential. Female. Headache / etiology. Humans. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Paresis / etiology

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  • (PMID = 19637021.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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28. Lee JY, Kondziolka D, Flickinger JC, Lunsford LD: Radiosurgery for intracranial meningiomas. Prog Neurol Surg; 2007;20:142-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for intracranial meningiomas.
  • INTRODUCTION: Meningiomas are common intracranial benign tumors that can be surgically excised.
  • MATERIALS AND METHODS: Between September 1987 and December 2004, 964 patients underwent Gamma Knife radiosurgery at the University of Pittsburgh for the diagnosis of meningioma.
  • RESULTS: Overall, Gamma Knife radiosurgery provides 5- and 10-year actuarial tumor control rates of 93% for benign meningiomas.
  • CONCLUSION: Gamma Knife radiosurgery is an attractive option for patients with intracranial meningiomas.
  • [MeSH-major] Brain Neoplasms / surgery. Meningioma / surgery. Radiosurgery / methods

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  • (PMID = 17317982.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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29. Cozzi L, Clivio A, Bauman G, Cora S, Nicolini G, Pellegrini R, Vanetti E, Yartsev S, Fogliata A: Comparison of advanced irradiation techniques with photons for benign intracranial tumours. Radiother Oncol; 2006 Aug;80(2):268-73
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  • [Title] Comparison of advanced irradiation techniques with photons for benign intracranial tumours.
  • BACKGROUND AND PURPOSE: The potential benefits and limitations of different radiation techniques (stereotactic arc therapy (SRS/T), intensity modulated radiotherapy (IMRT), helical tomotherapy (HT), Cyberknife and intensity-modulated multiple arc therapy (AMOA)) have been assessed using comparative treatment planning methods on twelve patients presenting with 'benign' brain tumours.
  • [MeSH-minor] Humans. Meningioma / radiotherapy. Neurilemmoma / radiotherapy. Radiotherapy, Intensity-Modulated / methods. Stereotaxic Techniques. Tomography, Spiral Computed / methods

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  • (PMID = 16890315.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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30. Noël G, Bollet MA, Calugaru V, Feuvret L, Haie-Meder C, Dhermain F, Ferrand R, Boisserie G, Beaudré A, Mazeron JJ, Habrand JL: Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. Int J Radiat Oncol Biol Phys; 2005 Aug 1;62(5):1412-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons.
  • PURPOSE: To evaluate efficacy and tolerance of external fractionated combination of photon and proton radiation therapy (RT) for intracranial benign meningiomas.
  • METHODS AND MATERIALS: Between 1994 and 2002, 51 patients with intracranial meningiomas of the base of the skull were treated with a combination of photon and proton RT.
  • Pathology revealed a malignant (Grade 3) transformation of the initial Grade 1 meningioma.
  • [MeSH-major] Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy. Photons / therapeutic use. Protons / therapeutic use. Radiotherapy, Conformal / methods. Visual Acuity

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  • (PMID = 16029801.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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31. Lichtenbaum R, de Souza AA, Jafar JJ: Intratumoral hydrogen peroxide injection during meningioma resection. Neurosurgery; 2006 Oct;59(4 Suppl 2):ONS470-3; discussion ONS473
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  • [Title] Intratumoral hydrogen peroxide injection during meningioma resection.
  • OBJECTIVE: Meningiomas, although histologically benign, pose a particular challenge to the neurosurgeon because of their extensive and exuberant vascularity.
  • Although anecdotally known to be useful, the use of hydrogen peroxide as an intracranial hemostatic agent in meningioma surgery has not been formally reported.
  • We report a technique of meningioma resection that uses intratumoral hydrogen peroxide injection, reducing the potential for blood loss and shortening resection times.
  • METHODS: Seventy-five patients underwent resection of a meningioma using the direct intratumoral H2O2 injection technique.
  • CONCLUSION: We demonstrate a previously unreported technique of meningioma resection that uses direct intratumoral hydrogen peroxide injection, potentially reducing blood loss, shortening resection times, and obviating the need for preoperative embolization.
  • [MeSH-major] Cerebral Hemorrhage / prevention & control. Hydrogen Peroxide / administration & dosage. Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / surgery. Meningioma / drug therapy. Meningioma / surgery. Neurosurgical Procedures / adverse effects

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  • (PMID = 17041519.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemostatics; BBX060AN9V / Hydrogen Peroxide
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32. Tao Y, Wei Q, Xu Z, Bai R, Li Y, Luo C, Dong Y, Gao G, Lu Y: Holistic and network analysis of meningioma pathogenesis and malignancy. Biofactors; 2006;28(3-4):203-19
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  • [Title] Holistic and network analysis of meningioma pathogenesis and malignancy.
  • Meningiomas, which originate from arachnoid cells and constitute the largest subgroup of all intracranial tumors, are generally benign, yet have the capacity to progress into a higher histological grade of malignancy associated with an increase in biological aggressivity and/or capacity to recur.
  • To elucidate meningioma pathogenesis and malignancy, we applied a holistic and network approach analyzing cDNA and tissue microarray results.
  • A potential pathway leading to meningioma angiogenesis, apoptosis and proliferation was evidenced as well as a regulatory network of the biomarkers including Ki-67, AR, CD34, P53, c-MYC, etc. which might support clinical research.
  • Some genes are first reported that could explain why radiation induces meningioma and why more female than male patients are affected.
  • Further, we present the hypothesis that HIV-Tat protein might have a close relationship with meningioma pathogenesis and malignancy.
  • [MeSH-major] Biomarkers, Tumor / analysis. Meningioma / chemistry. Meningioma / pathology. Proteome / chemistry

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  • (PMID = 17473381.001).
  • [ISSN] 0951-6433
  • [Journal-full-title] BioFactors (Oxford, England)
  • [ISO-abbreviation] Biofactors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Biomarkers, Tumor; 0 / Gene Products, tat; 0 / Proteome; 52500-60-4 / Thioredoxins
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33. Wickremesekera A, Hovens CM, Kaye AH: Expression of ErbB-1 and ErbB-2 in meningioma. J Clin Neurosci; 2010 Sep;17(9):1155-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of ErbB-1 and ErbB-2 in meningioma.
  • Meningiomas are benign intracranial tumours treated by neurosurgical resection.
  • These preliminary results implicate a potential role for ErbB-2 in the benign tumourigenesis of meningioma consistent with the theoretical hierarchical interactions of homodimers of ErbB-2 that may be associated with low signal transduction.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20547458.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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34. Tena-Suck M, Collado-Ortiz MA, Rembao-Bojórquez D, Gestista N, García-Marquez A: Coexistence between meningioma and tuberculosis: case report. J Neurooncol; 2010 Sep;99(2):289-94
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  • [Title] Coexistence between meningioma and tuberculosis: case report.
  • Intracranial tuberculoma generally presents as either solitary or multiple lesions in the brain parenchyma.
  • Histology showed a benign meningioma with many multinuclear giant cells, granulomas, and central caseating necrosis.
  • The authors describe the unusual case of coexistence between an occipital meningioma and tuberculosis in the same area that resembled metastasis.
  • [MeSH-major] Meningeal Neoplasms / complications. Meningioma / complications. Tuberculosis, Meningeal / complications

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  • (PMID = 20195701.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Sahu S, Lata I, Gupta D: Management of pregnant female with meningioma for craniotomy. J Neurosci Rural Pract; 2010 Jan;1(1):35-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of pregnant female with meningioma for craniotomy.
  • Intracranial meningioma during pregnancy challenges the skill of obstetricians, neurosurgeons and neuroanesthesiologists in resection of the tumor and to secure delivery of the baby.
  • Urgent neurosurgical intervention is reserved for the management of malignancies, active hydrocephalus, and benign brain tumors associated with signs of impending herniation or progressive neurological deficit.

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  • [Cites] Acta Obstet Gynecol Scand. 2001 Feb;80(2):104-12 [11167203.001]
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  • (PMID = 21799618.001).
  • [ISSN] 0976-3155
  • [Journal-full-title] Journal of neurosciences in rural practice
  • [ISO-abbreviation] J Neurosci Rural Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3137832
  • [Keywords] NOTNLM ; Craniotomy / complications / meningioma / pregnancy
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36. Rim NJ, Kim HS, Kim SY: A "benign" sphenoid ridge meningioma manifesting as a subarachnoid hemorrhage associated with tumor invasion into the middle cerebral artery. Korean J Radiol; 2008 Jul;9 Suppl:S10-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A "benign" sphenoid ridge meningioma manifesting as a subarachnoid hemorrhage associated with tumor invasion into the middle cerebral artery.
  • Meningioma rarely manifests as a subarachnoid hemorrhage (SAH), and invasion directly into a major intracranial artery is extremely rare.
  • To the best of our knowledge, meningioma presenting with an SAH associated with major intracranial arterial invasion has never been reported.
  • We present a case of sphenoid ridge meningotheliomatous meningioma manifesting as an SAH without pathologically atypical or malignant features, due to direct tumor invasion into the middle cerebral artery.
  • [MeSH-major] Meningeal Neoplasms / complications. Meningioma / complications. Middle Cerebral Artery / pathology. Skull Neoplasms / complications. Sphenoid Bone. Subarachnoid Hemorrhage / etiology

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  • (PMID = 18607117.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627185
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37. Badr MA, Elkhamary SM, Al Sabbagh S, Al Turjoman A: Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient. Middle East Afr J Ophthalmol; 2008 Jul;15(3):138-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient.
  • Bilateral optic nerve sheath meningioma is rare.
  • A meningioma is a benign neoplastic lesion from meningothelial cells of the meninges.
  • They usually involve the intracanalicular portion of the optic nerve but may extend into the optic canal and through it to occupy the intracranial space.
  • We present a case of 25-year-old Saudi female with bilateral optic nerve sheath meningioma.

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  • (PMID = 21369471.001).
  • [ISSN] 0974-9233
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3040919
  • [Keywords] NOTNLM ; MRI / meningioma / optic nerve sheath meningioma / optic nerve tumor
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38. Deb P, Sarkar C, Garg A, Singh VP, Kale SS, Sharma MC: Intracranial gliofibroma mimicking a meningioma: a case report and review of literature. Clin Neurol Neurosurg; 2006 Feb;108(2):178-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial gliofibroma mimicking a meningioma: a case report and review of literature.
  • Gliofibromas are rare glio-mesenchymal tumors composed of astrocytic and benign mesenchymal components, which commonly occur in the first two decades of life.
  • We describe a case of histopathologically proven gliofibroma in the region of the left quadrigeminal plate in a 15-year-old child that mimicked a tentorial meningioma both at imaging and surgery.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Fibroma / diagnosis. Glioma / diagnosis. Meningioma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Third Ventricle

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  • (PMID = 16412839.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 24
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39. Johnson WD, Loredo LN, Slater JD: Surgery and radiotherapy: complementary tools in the management of benign intracranial tumors. Neurosurg Focus; 2008;24(5):E2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery and radiotherapy: complementary tools in the management of benign intracranial tumors.
  • Historically, radiation therapy has been used extensively in the treatment of malignant and aggressive intracranial tumors, and the importance of its role has been repeatedly verified by prolonged patient survival rates and increased tumor control.
  • As more modern capabilities are employed in surgery and radiotherapy, attention is being directed to the utility of radiation as either primary or secondary treatment of benign tumors.
  • Specifically, primary treatment encompasses irradiation of small benign tumors without biopsy confirmation of tumor type; secondary treatment involves postoperative radiation therapy, with the possibility that less-aggressive tumor resection may be performed in areas that have a higher probability of resultant neurological deficit.
  • This article provides an overview of factors to consider in the use of radiation therapy and reviews the relationships between radiation and surgery, notably the unique complementary role each plays in the treatment of benign intracranial tumors.
  • [MeSH-minor] Adenoma / radiotherapy. Adenoma / surgery. Combined Modality Therapy. Dose Fractionation. Elementary Particles / therapeutic use. Humans. Meningeal Neoplasms / radiotherapy. Meningeal Neoplasms / surgery. Meningioma / radiotherapy. Meningioma / surgery. Neurilemmoma / radiotherapy. Neurilemmoma / ultrasonography. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery. Radioisotopes / therapeutic use. Radiosurgery / instrumentation. Radiosurgery / methods. Radiotherapy, Computer-Assisted / methods

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  • (PMID = 18447741.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radioisotopes
  • [Number-of-references] 55
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40. Qi ZG, Li YX, Wang Y, Geng DY, Li KC, Shen TZ, Chen XR: Lipid signal in evaluation of intracranial meningiomas. Chin Med J (Engl); 2008 Dec 5;121(23):2415-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipid signal in evaluation of intracranial meningiomas.
  • BACKGROUND: Using magnetic resonance imaging, diagnosis of malignant meningioma from benign meningioma with atypical features is uncertain.
  • We evaluated the value of lipid signal in differentiating intracranial meningiomas.
  • RESULTS: Twenty-nine meningiomas were histologically benign (eleven meningothelial, thirteen fibrous, four transitional and one microcystic), three were atypical, and two were anaplastic.
  • With creatinine peak in the normal white matter chosen as internal standard, lipid/creatinine ratios of anaplastic, atypical and benign meningiomas were 0.844 +/- 0.027 (range from 0.725 to 0.994), 0.465 +/- 0.023 (range from 0.239 to 0.724), and 0.373 +/- 0.016 (range from 0.172 to 0.571) respectively.
  • Patchy necrosis was observed in anaplastic meningioma, while focal necrosis was noted in atypical meningioma with HE stain.
  • However, no necrosis was found in benign group.
  • KP-1 stain demonstrated histocytes containing lipids in the necrotic region of anaplastic and atypical meningioma.
  • CONCLUSION: The lipid signal at 1.3 ppm is a useful marker in evaluating the malignancy of intracranial meningiomas, especially in the differential diagnosis of anaplastic meningioma.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Magnetic Resonance Spectroscopy / methods. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 19102960.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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41. Mourad A, Guichard JP, Vignal C, Bousser MG, Vahedi K: Sphenoid and optic nerve sheath meningioma revealed by recurrent brain infarctions. Rev Neurol (Paris); 2009 Dec;165(12):1092-4
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  • [Title] Sphenoid and optic nerve sheath meningioma revealed by recurrent brain infarctions.
  • Meningioma, though benign, may invade adjacent structures such as bone, soft tissues, dural sinuses and arteries.
  • However brain infarctions secondary to meningioma involving the cavernous sinus and encasing and narrowing the intracranial carotid artery are rare.
  • We report the case of a young man with recurrent left carotid artery infarctions due to a left sphenoid meningioma infiltrating the posterior optic nerve sheath through the optic canal and circumscribing the intracranial carotid artery.
  • The patient had a gradually progressive occlusion of the middle cerebral artery, the distal internal carotid artery and finally the anterior cerebral artery ipsilateral to the sphenoid meningioma.
  • [MeSH-major] Cerebral Infarction / etiology. Meningioma / pathology. Optic Nerve Neoplasms / pathology. Sphenoid Bone / pathology

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  • (PMID = 19324384.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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42. Vachhrajani S, Jea A, Rutka JA, Blaser S, Cusimano M, Rutka JT: Meningioma with dural venous sinus invasion and jugular vein extension. J Neurosurg Pediatr; 2008 Dec;2(6):391-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningioma with dural venous sinus invasion and jugular vein extension.
  • Meningiomas represent the most common benign intracranial neoplasm in adults, with a considerably lower incidence in children.
  • The authors present the case of an intracranial meningioma with invasion of, and intraluminal extension into, the transverse and sigmoid sinuses, jugular bulb, and internal jugular vein, resulting in venous occlusion in a 14-year-old girl.
  • Gross-total resection was achieved by opening the lateral dural sinus and removing the meningioma from within the transverse and sigmoid sinuses, the jugular bulb, and the internal jugular vein.
  • This case illustrates the unusual property of an intracranial meningioma to invade the intrasinusoidal space and extend into the jugular vein without adherence to the underlying venous endothelium of the jugular vein.
  • [MeSH-major] Cranial Sinuses. Jugular Veins. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery

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  • (PMID = 19035683.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Gerszten PC, Burton SA, Ozhasoglu C, McCue KJ, Quinn AE: Radiosurgery for benign intradural spinal tumors. Neurosurgery; 2008 Apr;62(4):887-95; discussion 895-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for benign intradural spinal tumors.
  • OBJECTIVE: The role of stereotactic radiosurgery for the treatment of intracranial benign tumors is well established.
  • There is less experience and more controversy regarding its use for benign tumors of the spine.
  • This study evaluated the clinical efficacy of radiosurgery as part of the treatment paradigm of selected benign tumors of the spine.
  • METHODS: Seventy-three benign intradural extramedullary spinal tumors were treated with a radiosurgery technique and prospectively evaluated.
  • Tumor histology included neurofibroma (25 cases), schwannoma (35 cases), and meningioma (13 cases).
  • CONCLUSION: Single fraction radiosurgery was found to be clinically effective for the treatment of benign extramedullary spinal neoplasms.
  • Although surgical extirpation remains the primary treatment option for most benign spinal tumors, radiosurgery was demonstrated to have short-term clinical benefits for the treatment of such lesions.

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  • (PMID = 18496194.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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44. McGuire TP, Palme CE, Perez-Ordonez B, Gilbert RW, Sándor GK: Primary intraosseous meningioma of the calvaria: analysis of the literature and case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Oct;104(4):e34-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intraosseous meningioma of the calvaria: analysis of the literature and case report.
  • Meningiomas are the most common of the benign intracranial neoplasms.
  • We report the case of a rare primary intraosseous meningioma presenting as a localized, symptom-free supraorbital bony expansion in an 81-year-old female patient and tabulate the previously reported cases of primary intraosseous meningiomas of the craniomaxillofacial region for analysis.
  • [MeSH-major] Frontal Bone / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Skull Neoplasms / pathology

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  • (PMID = 17656124.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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45. Samadi N, Ahmadi SA: Meningioma: a clinicopathological evaluation. Malays J Med Sci; 2007 Jan;14(1):46-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningioma: a clinicopathological evaluation.
  • We evaluate epidemiologic factors of meningioma in Iran & degree of agreement between the two commonly used grading systems namely WHO (2000) and Mahmood systems.
  • 205(86.1%) cases were benign, 19(8%) atypical and 14(5.9%) malignant.
  • 181(18%) cases were primary and 51(27%) secondary; 35(68%) of the latter benign, 7(14%) atypical and 9(18%) malignant.
  • All intraspinal meningiomas were benign.
  • In benign cranial and spinal types female to male ratios were 1.9: 1 and 1.3: 1 ; while in atypical and malignant types were 1 :1.4 and 1:3.1 respectively.
  • Mean ages were 49.9 for benign.
  • The most frequent site of involvement in all grades of intracranial tumors was cerebral convexity (31.1 %).
  • Female preponderance seen in benign nonrecurrent meningioma became increasingly less prominent and even reversed in recurrent, atypical and malignant forms.
  • Benign recurrent tumors were similar to non-recurrent tumors microscopically.

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  • [Cites] Cancer. 2000 Sep 1;89(5):1102-10 [10964341.001]
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  • (PMID = 22593651.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3351217
  • [Keywords] NOTNLM ; Mahmood grading system / WHO grading system / brain tumor / intracranial / intraspinal / meningioma
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46. Ganesan D, Higgins JN, Harrower T, Burnet NG, Sarkies NJ, Manford M, Pickard JD: Stent placement for management of a small parasagittal meningioma. Technical note. J Neurosurg; 2008 Feb;108(2):377-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stent placement for management of a small parasagittal meningioma. Technical note.
  • The patient in this report had a parasagittal meningioma with an intrasinus extension that presented with features of benign intracranial hypertension and no focal neurological deficit or seizure.
  • The meningioma was managed with a combination of endovascular stent placement and radiotherapy.
  • [MeSH-major] Cerebrovascular Disorders / surgery. Cranial Sinuses / surgery. Meningioma / surgery. Stents
  • [MeSH-minor] Cerebral Angiography. Follow-Up Studies. Humans. Intracranial Hypertension / surgery. Magnetic Resonance Angiography. Male. Middle Aged. Visual Acuity / physiology

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  • (PMID = 18240939.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0001237; United Kingdom / Medical Research Council / / G0600986; United Kingdom / Medical Research Council / / G9439390
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Kuroda H, Kashimura H, Ogasawara K, Sugawara A, Sasoh M, Arai H, Ogawa A: Malignant intracranial meningioma with spinal metastasis--case report. Neurol Med Chir (Tokyo); 2009 Jun;49(6):258-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant intracranial meningioma with spinal metastasis--case report.
  • The tumor was histologically benign at the first operation, but exhibited unusually aggressive behavior after failed radiosurgery and demonstrated clinical characteristics of malignancy such as spinal metastasis.
  • [MeSH-major] Cell Transformation, Neoplastic / radiation effects. Meningeal Neoplasms / pathology. Meningioma / secondary. Neoplasm Metastasis / physiopathology. Radiosurgery / adverse effects. Spinal Cord Neoplasms / secondary

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  • (PMID = 19556736.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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48. Ahn ES, Chin LS, Gyure KA, Hudes RS, Ragheb J, DiPatri AJ Jr: Long-term control after resection and gamma knife surgery of an intracranial clear cell meningioma: case report. J Neurosurg; 2005 Apr;102(3 Suppl):303-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term control after resection and gamma knife surgery of an intracranial clear cell meningioma: case report.
  • Clear cell meningioma (CCM) is a rare variant of meningioma characterized by sheets of polygonal cells with clear cytoplasm, a feature attributable to its high glycogen content.
  • Authors have described its propensity to recur and metastasize despite its benign pathological characteristics.
  • The delayed recurrence also emphasizes the importance of undertaking close follow-up examination after treating this potentially aggressive variant of meningioma.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Stereotaxic Techniques

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  • (PMID = 15881755.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9005-79-2 / Glycogen
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49. Sakowitz OW, Harting I, Kohlhof P, Unterberg AW, Steiner HH: Acute haemorrhage into a microcystic meningioma leading to cerebral herniation. Br J Neurosurg; 2005 Jun;19(3):260-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute haemorrhage into a microcystic meningioma leading to cerebral herniation.
  • Low-grade (WHO level I) meningiomas are slow-growing, benign tumours typically presenting with unspecific symptoms (e.g. headache), seizures, cranial nerve compression and neuropsychological symptoms determined by location and size of the lesion.
  • This is a case of a 50-year-old male presenting with signs of tentorial herniation secondary to hyperacute intratumoural haemorrhage (ITH) into a previously undiagnosed meningioma.
  • ITH has been described in all including benign intracranial neoplasms.
  • [MeSH-major] Encephalocele / etiology. Intracranial Hemorrhages / complications. Meningeal Neoplasms / complications. Meningioma / complications

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  • (PMID = 16455530.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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50. Boviatsis EJ, Bouras TI, Kouyialis AT, Themistocleous MS, Sakas DE: Impact of age on complications and outcome in meningioma surgery. Surg Neurol; 2007 Oct;68(4):407-11; discussion 411
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of age on complications and outcome in meningioma surgery.
  • BACKGROUND: Surgery for benign brain tumors in elderly patients without severe general health problems is an acceptable practice, as results are comparable with the ones of younger patients.
  • CONCLUSIONS: Operation for intracranial meningioma in elderly patients is justified as long as detailed preoperative evaluation is performed.
  • [MeSH-major] Meningioma / surgery. Postoperative Complications / epidemiology. Supratentorial Neoplasms / surgery

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  • (PMID = 17586023.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Kondziolka D, Mathieu D, Lunsford LD, Martin JJ, Madhok R, Niranjan A, Flickinger JC: Radiosurgery as definitive management of intracranial meningiomas. Neurosurgery; 2008 Jan;62(1):53-8; discussion 58-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery as definitive management of intracranial meningiomas.
  • OBJECTIVE: Stereotactic radiosurgery has become an important primary or adjuvant minimally invasive management strategy for patients with intracranial meningiomas with the goals of long-term tumor growth prevention and maintenance of patient neurological function.
  • METHODS: The patient cohort consisted of 972 patients with 1045 intracranial meningiomas managed during an 18-year period.
  • RESULTS: The overall control rate for patients with benign meningiomas (World Health Organization Grade I) was 93%.
  • CONCLUSION: Stereotactic radiosurgery provided high rates of tumor growth control or regression in patients with benign meningiomas with low risk.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Radiosurgery / methods

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  • (PMID = 18300891.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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52. Dijkstra M, van Nieuwenhuizen D, Stalpers LJ, Wumkes M, Waagemans M, Vandertop WP, Heimans JJ, Leenstra S, Dirven CM, Reijneveld JC, Klein M: Late neurocognitive sequelae in patients with WHO grade I meningioma. J Neurol Neurosurg Psychiatry; 2009 Aug;80(8):910-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late neurocognitive sequelae in patients with WHO grade I meningioma.
  • BACKGROUND: Information on neurocognitive outcome following treatment of benign meningiomas is virtually lacking.
  • This is remarkable considering that survival in these patients is the most favourable of all intracranial tumours.
  • The aim of the present study was therefore to document the extent and nature of neurocognitive deficits in patients with World Health Organization (WHO) grade I meningioma after treatment.
  • METHODS: 89 patients with WHO grade I meningioma who underwent surgery with or without adjuvant radiotherapy were individually matched to 89 healthy controls for age, sex and educational level.
  • RESULTS: Compared with healthy controls, patients with meningioma showed significant impairments in executive functioning (p<0.001), verbal memory (p<0.001), information processing capacity (p = 0.001), psychomotor speed (p = 0.001) and working memory (p = 0.006).
  • CONCLUSIONS: Meningioma patients are characterised by long term deficits in neurocognitive functioning that can partly be attributed to the use of antiepileptic drugs and tumour location but not to the use of radiotherapy.
  • [MeSH-major] Cognition Disorders / etiology. Meningioma / complications

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  • (PMID = 18653549.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatr.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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53. Ferchichi L, Bellil S, Ben Hammouda K, Bellil K, Mekni A, Bettaieb I, Haouet S, Khaldi MM, Zitouna K, Kchir N: Anaplastic secretory meningioma: a case report. Pathologica; 2006 Apr;98(2):153-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic secretory meningioma: a case report.
  • Secretory meningiomas are rare histological subtypes of meningiomas with benign biological behaviour.
  • In this study, the authors describe the first case of secretory meningioma with many mitotic figures and brain invasion, and discuss the clinicopathologic features including immunohistochemical staining profile and ultrastructural appearance of this tumour.
  • A case of a 54-year-old man diagnosed with an intracranial tumour located in the left frontal lobe is presented.
  • The histological diagnosis was secretory meningioma with many mitotic figures, a high MIB-1 labeling index and a brain invasion.
  • [MeSH-major] Frontal Lobe / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 16929789.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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54. Isobe N, Oki S, Murakami T, Ooyama S, Kureshima M, Kurokawa Y: [A case of atypical meningioma with Lhermitte-Duclos disease]. No Shinkei Geka; 2005 Dec;33(12):1229-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of atypical meningioma with Lhermitte-Duclos disease].
  • We present a case of atypical meningioma with Lhermitte-Duclos disease.
  • But, the patient had neither cerebellar dysfunction nor signs of increased intracranial pressure.
  • The patient had angioma of the left breast and bilateral benign struma, no typical manifestation of Cowden syndrome.
  • The pathological examination was atypical meningioma.
  • However, we should continuously take account to not only the recurrence of meningioma but also the enlargement of the cerebellar lesion and the complication of malignant tumors in whole body.
  • [MeSH-major] Cerebellar Neoplasms / complications. Ganglioneuroma / complications. Meningeal Neoplasms / complications. Meningioma / complications

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  • (PMID = 16359035.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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55. Kao HW, Chen CY, Hsueh CJ, Lo CP, Juan CJ, Chang WC, Huang GS: Typical Meningioma with Atypical MR Imaging Features Masquerading Malignancy. A Case Report. Neuroradiol J; 2007 Oct 31;20(5):541-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Typical Meningioma with Atypical MR Imaging Features Masquerading Malignancy. A Case Report.
  • Meningiomas are the most common extraaxial tumors of intracranial neoplasms.
  • They are usually benign with characteristic pathologic and imaging features.
  • However, a histologically typical meningioma can have unusual or misleading imaging features that may not be suggestive of meningioma.
  • Here we present a fibrous meningioma with atypical magnetic resonance (MR) imaging features in a 76-year-old woman.

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  • (PMID = 24299943.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Lyons MK, Drazkowski JF, Wong WW, Fitch TR, Nelson KD: Metastatic prostate carcinoma mimicking meningioma: case report and review of the literature. Neurologist; 2006 Jan;12(1):48-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic prostate carcinoma mimicking meningioma: case report and review of the literature.
  • BACKGROUND: Intracranial dural-based lesions can be due to benign or malignant processes.
  • REVIEW SUMMARY: We report the case of a large dural-based adenocarcinoma of the prostate clinically and radiographically mimicking a meningioma.
  • We discuss the implications of dural-based intracranial lesions in patients with prostate cancer and review the literature of dural metastases, including the pathogenesis, tumor types, and clinical presentations.
  • CONCLUSION: The differential diagnosis of dural-based lesions in the brain varies from incidental and benign to symptomatic and malignant.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Brain Neoplasms / diagnosis. Brain Neoplasms / secondary. Meningioma / diagnosis. Prostatic Neoplasms / pathology

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  • (PMID = 16547447.001).
  • [ISSN] 1074-7931
  • [Journal-full-title] The neurologist
  • [ISO-abbreviation] Neurologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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57. Somerset HL, Kleinschmidt-DeMasters BK, Rubinstein D, Breeze RE: Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma. J Neurooncol; 2010 Jul;98(3):421-6
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  • [Title] Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma.
  • Intracranial chondromas are uncommon benign lesions usually attached to dura and located over the convexity of the skull.
  • Osteochondromas are even rarer and additionally contain a benign bony component.
  • Both lesions are reportedly difficult to distinguish from meningiomas on pre-operative neuroimaging studies, although few detailed pathologic-neuroimaging correlation studies have appeared in the literature, particularly for intracranial osteochondromas.
  • The bright signals were interpreted as showing multifocal hemorrhage and the mass was felt to be a convexity meningioma.
  • Extensive histological sectioning revealed a benign osteochondroma predominantly composed of lobules of hypocellular cartilage.
  • Microdissection of the different components revealed that the multifocal, spicule-like bright foci interpreted as hemorrhage on neuroimaging studies were instead foci of benign bone containing metaplastic bone marrow with trilineage hematopoietic cell populations and adipose tissue.
  • [MeSH-major] Bone Neoplasms / pathology. Dura Mater / pathology. Meningeal Neoplasms / physiopathology. Meningioma / physiopathology. Osteochondroma / pathology

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  • (PMID = 20012156.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Mosqueda-Taylor A, Domínguez-Malagon H, Cano-Valdez AM, Montiel-Hernandez AM: Primary extracranial meningioma of the mandible. Med Oral Patol Oral Cir Bucal; 2009 Apr;14(4):E167-70
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  • [Title] Primary extracranial meningioma of the mandible.
  • Meningiomas are benign tumors of mesodermal origin that arise from arachnoid cell clusters that penetrate the dura to form arachnoid villi.
  • They may arise as an extension of intracranial meningiomas or as primary tumors and may be clinically indistinguishable from other benign tumours of the jaws, as they usually present as a well-delineated unencapsulated tumors.
  • [MeSH-major] Mandibular Neoplasms. Meningioma

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  • (PMID = 19333184.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 16
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59. Fogliata A, Clivio A, Nicolini G, Vanetti E, Cozzi L: Intensity modulation with photons for benign intracranial tumours: a planning comparison of volumetric single arc, helical arc and fixed gantry techniques. Radiother Oncol; 2008 Dec;89(3):254-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intensity modulation with photons for benign intracranial tumours: a planning comparison of volumetric single arc, helical arc and fixed gantry techniques.
  • BACKGROUND AND PURPOSE: The potential benefits and limitations of the new RapidArc treatment concept compared to Helical Tomotherapy and fixed gantry intensity modulation techniques have been assessed at treatment planning level on 12 patients presenting with 'benign' brain tumours.
  • [MeSH-major] Adenoma / radiotherapy. Brain Neoplasms / radiotherapy. Meningioma / radiotherapy. Neuroma, Acoustic / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods

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  • (PMID = 18760851.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
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60. Agrawal A, Rao KS, Makannavar JH, Shetty L, Patel N: Extracranial meningioma in the vicinity of the temporal bone: a difficult preoperative diagnosis. Surg Neurol; 2007 Jan;67(1):102-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extracranial meningioma in the vicinity of the temporal bone: a difficult preoperative diagnosis.
  • BACKGROUND: Extracranial meningioma is a rare tumor, and most of the time only after histopathologic examination is diagnosis possible.
  • Computed tomography scan showed large enhancing predominantly extracranial lesion located in the right anterior frontotemporal region extending into the infratemporal fossa and a relatively thin sheet of tumor on the intracranial aspect of the thickened temporal.
  • Histopathologic features were suggestive of meningothelial meningioma arising from the temporal bone with predominant extracranial extension.
  • CONCLUSION: Preoperative suspicion of a meningioma in this patient would have resulted in a more aggressive surgical approach as these lesions are relatively benign with indolent course.
  • [MeSH-major] Meningioma / pathology. Skull Neoplasms / pathology. Temporal Bone / pathology

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  • (PMID = 17210319.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Keller A, Ludwig N, Comtesse N, Hildebrandt A, Meese E, Lenhof HP: A minimally invasive multiple marker approach allows highly efficient detection of meningioma tumors. BMC Bioinformatics; 2006;7:539
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A minimally invasive multiple marker approach allows highly efficient detection of meningioma tumors.
  • For validation purposes we choose the intracranial meningioma tumors as model system since they occur very frequently, are mostly benign, and are genetically stable.
  • RESULTS: A total of 183 blood samples from 93 meningioma patients (WHO stages I-III) and 90 healthy controls were screened for seroreactivity with a set of 57 meningioma-associated antigens.
  • [MeSH-major] Algorithms. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / immunology. Meningioma / diagnosis. Meningioma / immunology

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  • (PMID = 17184519.001).
  • [ISSN] 1471-2105
  • [Journal-full-title] BMC bioinformatics
  • [ISO-abbreviation] BMC Bioinformatics
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC1769403
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62. Rahmah NN, Horiuchi T, Nakayama J, Nitta J, Hongo K: Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma? Surg Neurol Int; 2010;1:60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?
  • BACKGROUND: The authors report a rare case of a patient with previously treated cutaneous malignant melanoma that recurred 1 year later as an intracranial meningioma.
  • Imaging study revealed an enhanced intracranial extradural mass with bone destruction.
  • Histological study revealed the intracranial mass to be an atypical meningioma.
  • This case serves to remind neurosurgeons of the potential existence of benign and/ or malignant tumors of neural crest origin.

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  • (PMID = 20975977.001).
  • [ISSN] 2152-7806
  • [Journal-full-title] Surgical neurology international
  • [ISO-abbreviation] Surg Neurol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2958332
  • [Keywords] NOTNLM ; Malignant melanoma / coexistence-losomarginal artery / meningioma / neural crest / recurrence
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63. Agar NY, Malcolm JG, Mohan V, Yang HW, Johnson MD, Tannenbaum A, Agar JN, Black PM: Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Anal Chem; 2010 Apr 1;82(7):2621-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
  • Often considered benign, meningiomas represent 32% of intracranial tumors with three grades of malignancy defined by the World Health Organization (WHO) histology based classification.
  • A preliminary classifier based on the support vector machine showed the ability to distinguish meningioma image spectra from the nontumor brain and from gliomas, a different type of brain tumor, and to enable class imaging of surgical tissue.

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  • (PMID = 20196536.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / U41 RR019703; United States / NIBIB NIH HHS / EB / U54 EB005149-030003; United States / NIBIB NIH HHS / EB / U54 EB005149; United States / NCRR NIH HHS / RR / P41 RR-13218; United States / NCRR NIH HHS / RR / RR013218-108435; United States / NCRR NIH HHS / RR / P41 RR013218-108435; United States / NCRR NIH HHS / RR / P41 RR013218; United States / NIBIB NIH HHS / EB / EB005149-030003
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS184740; NLM/ PMC2852177
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64. Nur S, Chuang L, Ramaswamy G: Primary extracranial meningioma of the pelvis: a light microscopic, immunohistochemical, and ultrastructural study. Gynecol Oncol; 2006 Nov;103(2):745-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary extracranial meningioma of the pelvis: a light microscopic, immunohistochemical, and ultrastructural study.
  • This presented case records a unique location, a meningioma arising in pelvis.
  • The histology of the resected tumor revealed sheets of bland epithelioid cells arranged in prominent whorls with psammoma bodies typical of meningothelial meningioma.
  • CONCLUSION: According to our review of literature, this is the first reported case of a primary pelvic meningioma.
  • Its benign appearance and 4-year disease-free survival without clinical or radiological evidence of intracranial disease favors the pelvis as the primary site.
  • [MeSH-major] Meningioma / metabolism. Meningioma / ultrastructure. Pelvic Neoplasms / metabolism. Pelvic Neoplasms / ultrastructure

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  • (PMID = 16904168.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Ochalski PG, Edinger JT, Horowitz MB, Stetler WR, Murdoch GH, Kassam AB, Engh JA: Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. J Neurosurg; 2010 May;112(5):978-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage.
  • To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease).
  • This is the second report of primary intracranial AFH.
  • Additionally, hemorrhage from an intracranial AFH lesion has yet to be reported, and little is known about the radiographic characteristics and biological behavior of these lesions.
  • In this report, the authors describe the case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH.
  • Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern.
  • [MeSH-major] Angiomatosis / complications. Angiomatosis / pathology. Cerebral Hemorrhage / complications. Cerebral Hemorrhage / pathology. Histiocytoma, Benign Fibrous / complications. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 19731989.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Yilmaz Z, Sahin FI, Atalay B, Ozen O, Caner H, Bavbek M, Demirhan B, Altinörs N: Chromosome 1p36 and 22qter deletions in paraffin block sections of intracranial meningiomas. Pathol Oncol Res; 2005;11(4):224-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosome 1p36 and 22qter deletions in paraffin block sections of intracranial meningiomas.
  • Meningiomas are the most frequent benign tumors of the intracranial cavity.
  • In this study, we aimed to detect 1p36 and 22qter deletions by fluorescence in situ hybridization (FISH) in archival materials of 50 intracranial meningioma patients.
  • The clinical material consisted of paraffin-embedded tissue sections from 50 patients who were surgically treated and had histopathologic diagnosis of an intracranial meningioma.
  • In addition, we observed 22qter deletion in 26/36 (72.2%) patients with meningothelial meningioma.
  • This finding implies that 22qter deletion might play an important role in the pathogenesis of meningothelial meningioma.
  • [MeSH-major] Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 22 / genetics. Meningeal Neoplasms / genetics. Meningioma / genetics

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  • (PMID = 16388319.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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67. Matsuo T, Hayashi Y, Ujifuku K, Baba S, Kamada K, Hayashi N, Nagata I: [Radiation injury after stereotactic irradiaton: especially long-term follow-up benign of targets]. No Shinkei Geka; 2009 Dec;37(12):1201-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Radiation injury after stereotactic irradiaton: especially long-term follow-up benign of targets].
  • OBJECTIVE: To analyses the result of linac radiosurgery (LRS) for the treatment of intracranial benign lesions and to assess possible factors related to complications.
  • Fifty-three patients with meningioma: Gr.
  • [MeSH-major] Intracranial Arteriovenous Malformations / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 19999552.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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68. Mehrotra N, Shamji MF, Vassilyadi M, Ventureyra EC: Intracranial tumors in first year of life: the CHEO experience. Childs Nerv Syst; 2009 Dec;25(12):1563-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial tumors in first year of life: the CHEO experience.
  • RESULTS: Eighteen cases of brain tumors in the first year of life were identified: 12 suptratentorial, eight with benign histology, and six infratentorial all with malignant histology.
  • Raised intracranial pressure was more than twice as prevalent with posterior fossa lesions (p < 0.01) with equivalent likelihood of increasing head circumference (p = 0.74), whereas seizures were more frequent with supratentorial tumors (p = 0.04).
  • [MeSH-major] Glioma / therapy. Infratentorial Neoplasms / therapy. Meningioma / therapy. Neuroectodermal Tumors, Primitive / therapy. Supratentorial Neoplasms / therapy. Teratoma / therapy

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  • (PMID = 19551387.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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69. Moon HS, Jung S, Jung TY, Cao VT, Moon KS, Kim IY: Possible role of matrix metalloproteinase in osteolytic intracranial meningiomas. J Korean Neurosurg Soc; 2010 Jan;47(1):11-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Possible role of matrix metalloproteinase in osteolytic intracranial meningiomas.
  • OBJECTIVE: Abnormalities of the bone are frequently encountered in patients with meningioma, and hyperostosis and endostosis are common bone alterations in these tumors.
  • Extensive bony destruction is very unusual in patients with meningioma.
  • We report six cases of intracranial meningioma associated with an osteolytic lesion of the skull and discuss the underlying mechanisms that may be responsible for bone destruction in patients with meningioma.
  • The tumor was classified as intracranial or extracranial, depending on its location.
  • We investigated the potential role of matrix metalloproteinase (MMP) in meningioma-associated osteolysis.
  • Histological examination revealed benign meningioma in four cases, and two cases of atypical meningioma.
  • Patients did not have a poor prognosis except one case of recurred atypical meningioma.
  • Gelatin zymography and RT-PCR detected high levels of MMP-2 in almost all extracranial masses in comparison with the intracranial masses and MMP-9 in two.
  • Invasion to the extracranial portion and osteolysis might be associated with MMP-2 expression in meningioma.

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  • (PMID = 20157372.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2817509
  • [Keywords] NOTNLM ; Matrix metalloproteinase / Meningioma / Osteolytic
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70. Colombo F, Casentini L, Cavedon C, Scalchi P, Cora S, Francescon P: Cyberknife radiosurgery for benign meningiomas: short-term results in 199 patients. Neurosurgery; 2009 Feb;64(2 Suppl):A7-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyberknife radiosurgery for benign meningiomas: short-term results in 199 patients.
  • OBJECTIVE: To present initial, short-term results obtained with an image-guided radiosurgery apparatus (CyberKnife; Accuray, Inc., Sunnyvale, CA) in a series of 199 benign intracranial meningiomas.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Radiosurgery / methods

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  • (PMID = 19165077.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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71. Sturges BK, Dickinson PJ, Bollen AW, Koblik PD, Kass PH, Kortz GD, Vernau KM, Knipe MF, Lecouteur RA, Higgins RJ: Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs. J Vet Intern Med; 2008 May-Jun;22(3):586-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs.
  • BACKGROUND: Intracranial meningiomas are the most common primary brain tumors in dogs.
  • HYPOTHESIS: Canine intracranial meningiomas are a heterogenous group of tumors with differing histological subtypes and grades.
  • ANIMALS: One hundred and twelve dogs with a histological diagnosis of intracranial meningioma.
  • The incidence of specific tumor grades was 56% benign (Grade I), 43% atypical (Grade II), and 1% malignant (Grade III).
  • MRI characteristics do not allow for prediction of meningioma subtype or grade, emphasizing the necessity of histopathology for antemortem diagnosis.

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  • (PMID = 18466258.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Kondraganti S, Gondi CS, McCutcheon I, Dinh DH, Gujrati M, Rao JS, Olivero WC: RNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth. Int J Oncol; 2006 Jun;28(6):1353-60
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  • [Title] RNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth.
  • Similar to gliomas, malignant meningiomas also exhibit elevated protease levels in comparison to normal brain and benign meningiomas.
  • As determined by Western blotting and fibrin zymography, pU2 effectively inhibited uPAR protein levels and uPA enzymatic activity in meningioma cells (IOMM-Lee).
  • In vitro studies (Matrigel invasion and spheroid migration) revealed reduced meningioma cell invasion and migration.
  • In addition, in vivo studies of mice injected with pU2-transfected meningioma cells revealed inhibition of intracranial tumor formation.

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  • (PMID = 16685436.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS47699; United States / NCI NIH HHS / CA / R01 CA075557; United States / NCI NIH HHS / CA / CA75557; United States / NCI NIH HHS / CA / CA116708; United States / NCI NIH HHS / CA / CA95058; United States / NCI NIH HHS / CA / R01 CA116708; United States / NINDS NIH HHS / NS / R01 NS047699; United States / NCI NIH HHS / CA / R01 CA095058; United States / NCI NIH HHS / CA / R01 CA092393; United States / NCI NIH HHS / CA / CA92393
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / PLAUR protein, human; 0 / Plaur protein, mouse; 0 / RNA, Neoplasm; 0 / Receptors, Cell Surface; 0 / Receptors, Urokinase Plasminogen Activator; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
  • [Other-IDs] NLM/ NIHMS9142; NLM/ PMC1459538
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73. Aksu G, Ulutin C, Fayda M, Saynak M: Cerebellar and multiple spinal hemangioblastomas and intraventricular meningioma managed with subtotal resection and external beam radiotherapy; report of a case with literature review. J BUON; 2005 Jul-Sep;10(3):405-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar and multiple spinal hemangioblastomas and intraventricular meningioma managed with subtotal resection and external beam radiotherapy; report of a case with literature review.
  • Hemangioblastomas are cystic, highly vascular benign neoplasms that constitute 1.5-2.5% of all intracranial tumors and 7-10% of primary posterior fossa tumors.
  • This disease consists of multiple intracranial, retinal and spinal hemangioblastomas, pheochromocytoma, retinal angiomas, pancreatic cysts, renal cell carcinomas and adrenal tumors.
  • Our patient was a 21-year-old male who presented with cerebellar and multiple spinal hemangioblastomas, and intraventricular meningioma.
  • Intracranial and spinal lesions were treated with external beam radiotherapy following subtotal excision of the cerebellar lesion.

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  • (PMID = 17357198.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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74. Gallina P, Buccoliero AM, Mariotti F, Mennonna P, Di Lorenzo N: Oncocytic meningiomas: Cases with benign histopathological features and a favorable clinical course. J Neurosurg; 2006 Nov;105(5):736-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic meningiomas: Cases with benign histopathological features and a favorable clinical course.
  • OBJECT: Oncocytic meningioma has recently been recognized as a distinct morphological variant of intracranial meningothelial neoplasms, and only a few cases have been reported in the literature.
  • METHODS: The authors report on five cases of intracranial oncocytic meningiomas.
  • CONCLUSIONS: Data in the presented cases did not confirm a previously described propensity to aggressiveness in this meningioma subtype.
  • In fact, the histological features as well as the long-term favorable clinical course may suggest benign behavior of such neoplasms, as in the common forms of meningiomas.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery. Oxyphil Cells / physiology

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  • (PMID = 17121136.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody
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75. Marcus HJ, Price SJ, Wilby M, Santarius T, Kirollos RW: Radiotherapy as an adjuvant in the management of intracranial meningiomas: are we practising evidence-based medicine? Br J Neurosurg; 2008 Aug;22(4):520-8
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  • [Title] Radiotherapy as an adjuvant in the management of intracranial meningiomas: are we practising evidence-based medicine?
  • The objective of this study, therefore, was to appraise the evidence for adjuvant radiotherapy in benign and atypical intracranial meningiomas, and to compare and contrast it with the current opinion and practice of neurosurgeons in the United Kingdom and the Republic of Ireland.
  • We performed a systematic review of the evidence for adjuvant radiotherapy in benign and atypical intracranial meningiomas, surveyed current opinion amongst neurosurgeons involved in such cases and ascertained local practice using data from the regional cancer registry.
  • Our survey demonstrated that the vast majority (98%) of neurosurgeons would not recommend adjuvant radiotherapy in grade I meningioma.
  • In grade II meningioma, most (80%) would not advocate adjuvant radiotherapy if completely excised, but the majority (59%) would recommend radiotherapy in cases of subtotal resection.
  • [MeSH-major] Evidence-Based Medicine. Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy

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  • (PMID = 18803079.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 67
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76. Delgado-López PD, Martín-Velasco V, Castilla-Díez JM, Fernández-Arconada O, Corrales-García EM, Galacho-Harnero A, Rodríguez-Salazar A, Pérez-Mies B: Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature. Neurocirugia (Astur); 2006 Jun;17(3):240-9
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  • [Title] Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature.
  • INTRODUCTION: One in every thousand intracranial meningiomas metastatize extracranially.
  • To our knowledge, this is the first description of a total en bloc spondylectomy through a posterior approach for the treatment of an intraosseous metastatic meningioma to the eleventh dorsal vertebra.
  • CASE REPORT: In March 1996, a 37 year-old male underwent surgical resection for a left occipital intraventricular benign meningioma (WHO I).
  • Advice from a second pathologist was seeked, who suggested the diagnosis of intraosseous meningioma.
  • Definite pathology: benign meningioma (WHO I).
  • DISCUSSION: Distant metastases from intracranial meningiomas are rare entities, arising from benign lesions in, at least, 60% of cases.
  • Enam et al proposed a specific pathological score to differentiate benign, atypic and malignant meningiomas.
  • The interval between the onset of the intracranial disease and the appearance of the metastasis varies from months to many years.
  • [MeSH-major] Meningioma / pathology. Orthopedic Procedures / methods. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery. Thoracic Vertebrae

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  • (PMID = 16855782.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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77. Hinduja A, Aguilar LG, Steineke T, Nochlin D, Landolfi JC: Rosai-Dorfman disease manifesting as intracranial and intraorbital lesion. J Neurooncol; 2009 Mar;92(1):117-20
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  • [Title] Rosai-Dorfman disease manifesting as intracranial and intraorbital lesion.
  • Rosai-Dorfman disease is a rare benign idiopathic histioproliferative disorder usually manifesting as massive painless adenopathy.
  • Extranodal involvement of the Central Nervous System (CNS) mimicking a skull base meningioma is rare.
  • [MeSH-minor] Adult. Antineoplastic Agents, Hormonal / therapeutic use. Combined Modality Therapy. Dexamethasone / therapeutic use. Diabetes Mellitus, Type 2. Diagnosis, Differential. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / pathology. Meningioma / pathology. Orbital Neoplasms / pathology. Radiotherapy. S100 Proteins / metabolism. Skull Base Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 19020807.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / S100 Proteins; 7S5I7G3JQL / Dexamethasone
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78. Nakamura M, Roser F, Michel J, Jacobs C, Samii M: Volumetric analysis of the growth rate of incompletely resected intracranial meningiomas. Zentralbl Neurochir; 2005 Feb;66(1):17-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Volumetric analysis of the growth rate of incompletely resected intracranial meningiomas.
  • OBJECTIVE: Intracranial meningiomas are mostly considered to be slow growing tumors.
  • The aim of this study was to determine the growth rates of intracranial meningiomas after subtotal resection, analysing their relation to radiological appearance and histological features.
  • METHODS: The hospital charts, follow up records and imaging studies were reviewed in 36 patients with subtotally resected intracranial meningiomas.
  • CONCLUSION: The majority of intracranial meningiomas are slow growing tumors, although the growth rates may vary widely even among benign grade 1 meningiomas.
  • [MeSH-major] Meningioma / pathology. Meningioma / surgery. Neurosurgical Procedures

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  • (PMID = 15744624.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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79. Nagulić M, Tukić L, Ilić S, Marković M: [Intracranial menigioma manifested after delivery in a patient with Hodgkin's disease]. Vojnosanit Pregl; 2006 Mar;63(3):305-8
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  • [Title] [Intracranial menigioma manifested after delivery in a patient with Hodgkin's disease].
  • BACKGROUND: Intracranial meningioma is rerely reported in the patients treated for Hodgkin's disease (HD), known to mainly occur in the area of radiation therapy.
  • CASE REPORT: A 26-year-old woman with HD, and intracranial meningioma following the delivery, was presented.
  • Three years prior the surgery for intracranial tumor, the patient had been started to be treated for HD of neoplasm stage I (NS I) type, by the use of the standard (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) BEA-COPP protocol.
  • Two days following the normal delivery, during the acute disorder of the consciousness, intracranial tumor was found.
  • A complete bilateral meningioma (11.7 x 8.3 x 8.1 cm) of the frontal parietal zone was removed.
  • CONCLUSION: there were no reliable signs of the use of an intensive hemotherapy in the reported case (alkylating cytostatics and topoisomerases inhibitors) which might have caused the proliferation of a benign solid tumor.
  • The pregnancy was supposed to be the possible second risk factor for causing the growth of a meningioma.
  • On the basis of the significant psychic disorders before the pregnancy, as well as upon the size of the operated on tumor, we concluded that the occurrence of intracranial meningioma could be regarded the parallel neoplastic disease or the second primary tumor.
  • [MeSH-major] Hodgkin Disease. Meningeal Neoplasms. Meningioma. Pregnancy Complications, Neoplastic

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  • (PMID = 16605198.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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80. Strassner C, Buhl R, Mehdorn HM: Recurrence of intracranial meningiomas: did better methods of diagnosis and surgical treatment change the outcome in the last 30 years? Neurol Res; 2009 Jun;31(5):478-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of intracranial meningiomas: did better methods of diagnosis and surgical treatment change the outcome in the last 30 years?
  • OBJECTIVE: Meningiomas are benign intracranial tumors growing from the arachnoid cap cells.
  • Although their behavior is usually benign, they tend to recur even after total removal, and their recurrence is dependent on different aspects.
  • METHODS: Between 1991 and 2002, 463 patients with an intracranial meningioma were operated in the Department of Neurosurgery, University of Kiel, Kiel, Germany.
  • We compared the outcome of these patients after operation and the different methods of radiation therapy and chemotherapy with the data from Buhl (1994), who analysed 661 patients with intracranial meningioma who were operated on in the Department of Neurosurgery, University of Essen, Essen, Germany, between 1968 and 1988, to find out whether better methods of diagnosis like magnetic resonance imaging scans, magnetic resonance spectroscopy, post-operative radiation therapy and chemotherapy have an influence on the recurrence and outcome after surgical treatment.
  • Both studies underlined the preponderance of female patients for intracranial meningiomas.
  • The intracranial localization of the meningiomas was similar to the distribution of the histological subtypes and the rate of recurrence; only the malignant meningiomas showed a higher grade of recurrence in the last study.
  • The outcome of the patients after surgical removal was improving in the last years; the 30 day post-operative mortality after a primary operation on an intracranial meningioma decreased from 12.1 to 3%.
  • After removal of a recurrent meningioma, the mortality declined from 20 to 12.5%.
  • With better operating modalities and additional treatment with radiation and gamma knife, the mortality decreased significantly from 12 to 3% and the outcome of the patients is still improving, so that even elderly patients with intracranial meningioma can undergo surgical treatment with minor risks.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / therapy. Meningioma / diagnosis. Meningioma / therapy

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  • (PMID = 19500450.001).
  • [ISSN] 0161-6412
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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81. Roser F, Nakamura M, Ritz R, Bellinzona M, Dietz K, Samii M, Tatagiba MS: Proliferation and progesterone receptor status in benign meningiomas are not age dependent. Cancer; 2005 Aug 1;104(3):598-601
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  • [Title] Proliferation and progesterone receptor status in benign meningiomas are not age dependent.
  • In the current study, proliferation activity with the Ki-67/MIB-1 antibody was evaluated by immunohistochemistry in meningioma tissue specimens from young and elderly patients.
  • RESULTS: Compared with the young group of 344 patients with meningioma (age < 70 years; mean age, 51.9 years; range, 18-69 years), the elderly population (age > or = 70 years; n = 41; mean age, 74.9 years; range, 70-88 years) showed a male-to-female ratio of 3.2: 1.
  • CONCLUSIONS: Proliferation rates and PR status in benign intracranial meningiomas did not appear to be age dependent.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cell Proliferation. Ki-67 Antigen / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Receptors, Progesterone / metabolism

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 15952201.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MIB-1 antibody; 0 / Receptors, Progesterone
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82. Monfared A, Agrawal S, Jackler RK: Cranial base approaches to inaccessible intracranial tumors. Curr Opin Neurol; 2007 Dec;20(6):726-31
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  • [Title] Cranial base approaches to inaccessible intracranial tumors.
  • The increasingly documented efficacy of stereotactic radiation for certain tumor types (e.g. meningioma, schwannoma) has permitted nonoperative therapy for some individuals.
  • The role for transbasal craniotomy is well established in both benign tumors and vascular lesions, but has only limited applicability for high-grade malignant lesions.
  • SUMMARY: Operative trajectories created through the cranial base, although technically demanding, have led to substantially improved outcomes for a wide variety of inaccessible intracranial lesions.

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  • (PMID = 17992097.001).
  • [ISSN] 1350-7540
  • [Journal-full-title] Current opinion in neurology
  • [ISO-abbreviation] Curr. Opin. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 55
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83. Bledsoe JM, Link MJ, Stafford SL, Park PJ, Pollock BE: Radiosurgery for large-volume (&gt; 10 cm3) benign meningiomas. J Neurosurg; 2010 May;112(5):951-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for large-volume (> 10 cm3) benign meningiomas.
  • OBJECT: Stereotactic radiosurgery (SRS) has proven to be a safe and effective treatment for many patients with intracranial meningiomas.
  • CONCLUSIONS: The morbidity associated with SRS for patients with benign meningiomas > 10 cm(3) is greater for supratentorial tumors compared with skull base tumors.
  • [MeSH-major] Meningioma / pathology. Meningioma / surgery. Radiosurgery / instrumentation. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery

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  • [CommentIn] J Neurosurg. 2010 Dec;113(6):1335-6; author reply 1336-7 [20887089.001]
  • (PMID = 19764829.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Sciarretta V, Pasquini E, Frank G, Modugno GC, Cantaroni C, Mazzatenta D, Farneti G: Endoscopic treatment of benign tumors of the nose and paranasal sinuses: a report of 33 cases. Am J Rhinol; 2006 Jan-Feb;20(1):64-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic treatment of benign tumors of the nose and paranasal sinuses: a report of 33 cases.
  • BACKGROUND: The endoscopic approach can be used successfully for the treatment of benign tumors such as fibroosseous and vascular lesions, pleomorphic adenoma, glioma, meningioma, and schwannoma.
  • METHODS: Thirty-three patients diagnosed with benign tumors of the nasal cavity and paranasal sinuses and treated using an endoscopic approach were reviewed retrospectively.
  • The endoscopic approach was simple in 28 cases and associated with an external approach in 5 cases (because of an intracranial extension of the tumor in four patients and its location at the level of the anterior wall of the frontal sinus in the last case).
  • CONCLUSION: In selected cases, endoscopic surgery can be considered an effective treatment for the resection of benign tumors involving the sinonasal tract.
  • [MeSH-minor] Adolescent. Adult. Aged. Angiofibroma / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Glioma / surgery. Hemangioma, Cavernous / surgery. Humans. Magnetic Resonance Imaging. Male. Meningioma / surgery. Middle Aged. Osteoma / surgery. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16539297.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Sayagués JM, Tabernero MD, Maíllo A, Trelles O, Espinosa AB, Sarasquete ME, Merino M, Rasillo A, Vera JF, Santos-Briz A, de Alava E, Garcia-Macias MC, Orfao A: Microarray-based analysis of spinal versus intracranial meningiomas: different clinical, biological, and genetic characteristics associated with distinct patterns of gene expression. J Neuropathol Exp Neurol; 2006 May;65(5):445-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microarray-based analysis of spinal versus intracranial meningiomas: different clinical, biological, and genetic characteristics associated with distinct patterns of gene expression.
  • Here, we compare the clinico-biological characteristics as well as the genetic abnormalities and patterns of gene expression of spinal and intracranial meningiomas.
  • Fourteen spinal and 141 intracranial meningioma patients were analyzed at diagnosis.
  • Additionally, microarray analyses were performed on a subgroup of 18 histologically benign meningiomas (7 spinal and 11 intracranial).
  • Upon comparison with intracranial tumors, spinal meningiomas showed a marked predominance of psammomatous and transitional tumors (p = 0.001), together with a higher proportion of cases displaying a single tumor cell clone by iFISH (p = 0.004).
  • In 86% of the spinal versus 56% of the intracranial tumors (p = 0.01), the ancestral tumor cell clone detected showed either absence of any chromosomal abnormality or monosomy 22/22q- alone.
  • Analysis of gene expression profiles showed differential expression between spinal and intracranial meningiomas for a total of 1555 genes, 35 of which allowed a clear distinction between both tumor types.
  • In summary, we show the occurrence of unique patterns of genetic abnormalities and gene expression profiles in spinal as compared to intracranial meningiomas that provide new insights into the molecular pathways involved in the tumorigenesis and progression of spinal meningiomas, and could help explain their particular clinical and histological features.
  • [MeSH-major] Gene Expression / physiology. Meningeal Neoplasms / genetics. Meningioma / genetics. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16772868.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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86. Ali AE, Fazl M, Bilbao JM: Primary intracranial leiomyoma: a case report and literature review. Virchows Arch; 2006 Sep;449(3):382-4
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  • [Title] Primary intracranial leiomyoma: a case report and literature review.
  • We report a case of primary intracranial leiomyoma in 29-year-old woman presented with severe headache.
  • The radiology diagnosis was consistent with meningioma.
  • However, histologically, the tumor had the characteristic appearance of benign smooth muscle.
  • Benign metastasizing leiomyoma was excluded by thorough imaging.
  • Although rare, leiomyoma should be considered in the differential diagnosis of well-circumscribed intracranial lesion.

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  • (PMID = 16896888.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calmodulin-Binding Proteins
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87. Bouvier C, Liprandi A, Colin C, Giorgi R, Quilichini B, Metellus P, Figarella-Branger D: Lack of alkaline phosphatase activity predicts meningioma recurrence. Am J Clin Pathol; 2005 Aug;124(2):252-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lack of alkaline phosphatase activity predicts meningioma recurrence.
  • Meningiomas usually are benign intracranial tumors.
  • [MeSH-major] Alkaline Phosphatase / biosynthesis. Biomarkers, Tumor / analysis. Meningeal Neoplasms / enzymology. Meningioma / enzymology. Neoplasm Recurrence, Local / enzymology

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  • (PMID = 16040297.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.1.3.1 / Alkaline Phosphatase
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88. Regelsberger J, Hagel C, Emami P, Ries T, Heese O, Westphal M: Secretory meningiomas: a benign subgroup causing life-threatening complications. Neuro Oncol; 2009 Dec;11(6):819-24
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  • [Title] Secretory meningiomas: a benign subgroup causing life-threatening complications.
  • While meningiomas are known as slow-growing extracerebral neoplasms, the subgroup of secretory meningiomas with histologically benign characteristics tend to cause disproportional peritumoral edema, frequently leading to severe medical and neurological complications in postoperative management.
  • Among 1,484 meningiomas that were resected at our institution between 1990 and 2007, 44 (3%) patients were found to have the histological diagnosis of a secretory meningioma.
  • The clinical course, radiological appearance, and histopathological features were retrospectively analyzed to examine the specifics of these benign lesions.
  • Six patients showed midline shift and clinical worsening necessitating respirator-assisted ventilation and intracranial pressure monitoring.
  • [MeSH-major] Brain Edema / etiology. Meningeal Neoplasms / complications. Meningeal Neoplasms / metabolism. Meningioma / complications. Meningioma / metabolism

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  • [Cites] Adv Clin Path. 1999 Jul;3(3):47-53 [10655573.001]
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  • (PMID = 19066343.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Ki-67 Antigen; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2802401
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89. Zada G, Pagnini PG, Yu C, Erickson KT, Hirschbein J, Zelman V, Apuzzo ML: Long-term outcomes and patterns of tumor progression after gamma knife radiosurgery for benign meningiomas. Neurosurgery; 2010 Aug;67(2):322-8; discussion 328-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcomes and patterns of tumor progression after gamma knife radiosurgery for benign meningiomas.
  • OBJECT: To characterize the timing and patterns of long-term treatment failure after Gamma Knife radiosurgery (GKRS) for benign meningiomas.
  • METHODS: Data were retrospectively reviewed in 116 patients who underwent 136 GKRS treatments for benign intracranial meningiomas from 1996 to 2004.
  • CONCLUSIONS: GKRS demonstrates excellent long-term tumor control in the management of benign meningiomas.
  • [MeSH-major] Meningioma / pathology. Meningioma / surgery. Radiosurgery

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  • (PMID = 20644417.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Panagopoulos AT, Lancellotti CL, Veiga JC, de Aguiar PH, Colquhoun A: Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas. J Neurooncol; 2008 Aug;89(1):73-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas.
  • Most meningiomas are benign tumours of arachnoidal origin, although a small number have high proliferative rates and invasive properties which complicate complete surgical resection and are associated with increased recurrence rates.
  • Paraffin sections from 25 intracranial meningiomas were analysed for expression of the proteins vascular endothelial growth factor (VEGF), VEGF receptors Flt1 and Flk1, E-cadherin, metalloproteinases 2 and 9 (MMP2, MMP9), CD44, receptor for hyaluronic acid-mediated motility (RHAMM), hyaluronic acid (HA), CD45, cyclooxygenase 2 (COX2), brain fatty acid binding protein (BFABP), Ki67, and proliferating cell nuclear antigen (PCNA).
  • In conclusion Ki67, PCNA, MI, MVD, BFABP, and COX2 were significantly correlated with meningioma tumour grade and with each other.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cell Adhesion Molecules / biosynthesis. Fatty Acids / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Neoplasm Proteins / biosynthesis. Neovascularization, Pathologic / metabolism

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  • (PMID = 18418552.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / Eicosanoids; 0 / Fatty Acids; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Proliferating Cell Nuclear Antigen; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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91. Sajja R, Barnett GH, Lee SY, Harnisch G, Stevens GH, Lee J, Suh JH: Intensity-modulated radiation therapy (IMRT) for newly diagnosed and recurrent intracranial meningiomas: preliminary results. Technol Cancer Res Treat; 2005 Dec;4(6):675-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intensity-modulated radiation therapy (IMRT) for newly diagnosed and recurrent intracranial meningiomas: preliminary results.
  • The purpose of this study was to evaluate tumor control, complications, and outcome from intensity-modulated radiation therapy (IMRT) for intracranial meningiomas.
  • Between July 1997 and November 2003, patients with intracranial meningiomas were treated at our institution with the NOMOS Peacock system utilizing the Multileaf Intensity Modulating Collimator (MIMiC).
  • Thirty-five patients with 37 lesions (35 benign and two atypical histology) were identified with a minimum of six months of radiologic follow-up for this retrospective review.
  • In conclusion, intensity-modulated radiation therapy is a safe and effective treatment for some intracranial meningiomas.
  • [MeSH-major] Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy

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  • (PMID = 16292888.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Nakaya K, Chernov M, Kasuya H, Izawa M, Hayashi M, Kato K, Kubo O, Muragaki Y, Iseki H, Hori T, Okada Y, Takakura K: Risk factors for regrowth of intracranial meningiomas after gamma knife radiosurgery: importance of the histopathological grade and MIB-1 index. Minim Invasive Neurosurg; 2009 Oct;52(5-6):216-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors for regrowth of intracranial meningiomas after gamma knife radiosurgery: importance of the histopathological grade and MIB-1 index.
  • INTRODUCTION: The influence of histopathological grade and MIB-1 index of intracranial meningioma on the results of its radiosurgical management is not clear.
  • PATIENTS AND METHODS: Thirty-four intracranial meningiomas with known detailed histopathological diagnosis were analyzed.
  • Actuarial progression-free survival at 5 years after GKR for benign and non-benign meningiomas constituted 100 and 45%, respectively (p<0.0001).
  • CONCLUSION: Radiosurgery is a highly effective management option for benign intracranial meningiomas, but growth control of non-benign ones is significantly worse.
  • [MeSH-major] Antibodies, Antinuclear / metabolism. Antibodies, Monoclonal / metabolism. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / pathology. Radiosurgery

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  • (PMID = 20077361.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / MIB-1 antibody
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93. Barber AJ, Lawson DD, Field EA: Two case reports of orofacial paraesthesia demonstrating the role of the general dental practitioner in identifying patients with intracranial tumours. Prim Dent Care; 2009 Apr;16(2):55-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two case reports of orofacial paraesthesia demonstrating the role of the general dental practitioner in identifying patients with intracranial tumours.
  • After appropriate investigations, both patients were diagnosed as having benign intracranial tumours and were managed by a neurosurgeon.
  • [MeSH-major] Facial Nerve Diseases / etiology. Meningioma / complications. Neurilemmoma / complications. Paresthesia / etiology. Skull Base Neoplasms / complications

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  • (PMID = 19366520.001).
  • [ISSN] 1355-7610
  • [Journal-full-title] Primary dental care : journal of the Faculty of General Dental Practitioners (UK)
  • [ISO-abbreviation] Prim Dent Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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94. Rockhill J, Mrugala M, Chamberlain MC: Intracranial meningiomas: an overview of diagnosis and treatment. Neurosurg Focus; 2007;23(4):E1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial meningiomas: an overview of diagnosis and treatment.
  • Ninety percent of meningiomas are benign, 6% are atypical, and 2% are malignant.
  • Most patients in whom a meningioma is diagnosed undergo resection to relieve neurological symptoms.
  • When the meningioma is unresectable or all other treatments (surgery and radiotherapy) have failed, hormonal therapy or chemotherapy may be considered.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / therapy. Meningioma / diagnosis. Meningioma / therapy

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  • (PMID = 17961033.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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95. Galanov AV, Konovalov AN, Kornienko VN, Il'ialov SR, Kostiuchenko VV, Pronin IN, Mariashev SA, Iakovlev SB, Lubnin AIu, Serova NK, Nikonova NG: [First experience with a Gamma-knife unit used for radiosurgical treatment for intracranial space-occupying lesions]. Zh Vopr Neirokhir Im N N Burdenko; 2007 Jan-Mar;(1):3-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [First experience with a Gamma-knife unit used for radiosurgical treatment for intracranial space-occupying lesions].
  • The essence of the radiosurgical treatment is to apply the stereotactic technique to high-precision irradiation of small intracranial targets by narrow beams of ionizing radiation from external sources.
  • Three hundred and six patients with various intracranial diseases (137 with malignant tumors, 136 with benign tumors, and 33 patients with vascular diseases) underwent radiosurgery on a Gamma-Knife unit for over 1.5 years, from May 2005 to October 2006.
  • By summing up the first results, it can be noted that stereotactic radiosurgery using a Gamma-Knife unit is an effective and rather safe technique in the treatment of patients with various types of intracranial pathology, which maintains the high quality of life, reduces the likelihood of development of different neurological disorders after treatment and avoids the risk of operative complications.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brain Neoplasms / pathology. Brain Neoplasms / radiotherapy. Brain Neoplasms / surgery. Child. Child, Preschool. Equipment Design. Eye Diseases / surgery. Female. Humans. Male. Meningioma / radiotherapy. Meningioma / surgery. Middle Aged. Neoplasm Metastasis. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery

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  • (PMID = 17526246.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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96. Oruckaptan HH, Sarac S, Gedikoglu G: Primary intracranial myxoma of the lateral skull base: a rare entity in clinical practice. Turk Neurosurg; 2010 Jan;20(1):86-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intracranial myxoma of the lateral skull base: a rare entity in clinical practice.
  • Myxomas are rare benign tumors arising from mesenchymal tissues throughout the body.
  • Involvement of the skull base with intracranial extension is extremely rare, and only a few cases of primary intracranial myxomas have been described in the literature.
  • Such a localization and intracranial extension of myxomas is extremely unusual in clinical practice; the diagnosis therefore requires a high degree of suspicion and detailed histopathological examination.
  • The differential diagnosis frequently includes chondrosarcomas, chordoma, metastatic tumors of the skull, hemangiopericytoma, meningioma and other neoplasms of the dura and skull base in this location.

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  • (PMID = 20066630.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 68238-35-7 / Keratins
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97. Chung HT, Kim DG, Paek SH, Jung HW: Development of dose-volume relation model for gamma knife surgery of non-skull base intracranial meningiomas. Int J Radiat Oncol Biol Phys; 2009 Jul 15;74(4):1027-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Development of dose-volume relation model for gamma knife surgery of non-skull base intracranial meningiomas.
  • PURPOSE: To provide a dose-volume relationship for gamma knife surgery (GKS) of non-skull base intracranial meningiomas.
  • METHODS AND MATERIALS: The radiologic outcomes of GKS of 82 imaging-defined benign meningiomas located at non-skull base areas were analyzed.
  • [MeSH-major] Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Radiosurgery / methods

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  • (PMID = 19056186.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Haselsberger K, Maier T, Dominikus K, Holl E, Kurschel S, Ofner-Kopeinig P, Unger F: Staged gamma knife radiosurgery for large critically located benign meningiomas: evaluation of a series comprising 20 patients. J Neurol Neurosurg Psychiatry; 2009 Oct;80(10):1172-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Staged gamma knife radiosurgery for large critically located benign meningiomas: evaluation of a series comprising 20 patients.
  • OBJECTIVES: This study investigated the efficacy of staged radiosurgical treatment for intracranial meningiomas exceeding 3 cm in diameter.
  • METHODS: Between April 1992 and May 2008, staged gamma knife radiosurgery was performed in 20 patients with large benign meningiomas.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery

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  • (PMID = 19762911.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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99. Jabbour SK, Zhang Z, Arnold D, Wharam MD: Risk of second tumor in intracranial germinoma patients treated with radiation therapy: the Johns Hopkins experience. J Neurooncol; 2009 Jan;91(2):227-32
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  • [Title] Risk of second tumor in intracranial germinoma patients treated with radiation therapy: the Johns Hopkins experience.
  • BACKGROUND: We reviewed the risk of second tumor (ST), both malignant and benign, in germinoma survivors followed at the Johns Hopkins Hospital (JHH).
  • METHODS: Between 1977 and 2002, 27 patients with intracranial germinoma were treated with radiation therapy (RT).
  • One developed a benign falcine meningioma.

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  • (PMID = 18813873.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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100. Kondraganti S, Gondi CS, Gujrati M, McCutcheon I, Dinh DH, Rao JS, Olivero WC: Restoration of tissue factor pathway inhibitor inhibits invasion and tumor growth in vitro and in vivo in a malignant meningioma cell line. Int J Oncol; 2006 Jul;29(1):25-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Restoration of tissue factor pathway inhibitor inhibits invasion and tumor growth in vitro and in vivo in a malignant meningioma cell line.
  • Previous studies have shown high expression of TFPI-2 by benign tumors and low or absent expression in highly malignant tumors.
  • To investigate the role of TFPI-2 in the invasiveness of malignant meningiomas, we stably transfected the human meningioma cell line, IOMM-Lee, with a vector capable of expressing a transcript complementary to the full length of TFPI-2 mRNA in a sense orientation.
  • Finally, TFPI-2 overexpression inhibited intracranial tumor formation in nude mice.

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  • (PMID = 16773181.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS47699; United States / NCI NIH HHS / CA / R01 CA075557; United States / NCI NIH HHS / CA / CA75557; United States / NCI NIH HHS / CA / CA116708; United States / NCI NIH HHS / CA / CA95058; United States / NCI NIH HHS / CA / R01 CA116708; United States / NINDS NIH HHS / NS / R01 NS047699; United States / NCI NIH HHS / CA / R01 CA095058; United States / NCI NIH HHS / CA / R01 CA092393; United States / NCI NIH HHS / CA / CA92393
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Glycoproteins; 0 / Laminin; 0 / Lipoproteins; 0 / Proteoglycans; 0 / bcl-2-Associated X Protein; 0 / lipoprotein-associated coagulation inhibitor; 0 / tissue-factor-pathway inhibitor 2; 119978-18-6 / matrigel; 9007-34-5 / Collagen; 9007-43-6 / Cytochromes c; EC 3.4.22.- / Caspase 3
  • [Other-IDs] NLM/ NIHMS9141; NLM/ PMC1479607
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