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1. Simula MP, Cannizzaro R, Marin MD, Pavan A, Toffoli G, Canzonieri V, De Re V: Two-dimensional gel proteome reference map of human small intestine. Proteome Sci; 2009;7:10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two-dimensional gel proteome reference map of human small intestine.
  • BACKGROUND: The small intestine is an important human organ that plays a central role in many physiological functions including digestion, absorption, secretion and defense.
  • Adenoma is a benign tumor that has the potential to become cancerous.
  • This approach, may be useful for comparing similar protein samples in different laboratories and for the molecular characterization of intestinal pathologies without recurring to the use of surgical material.

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  • [Cites] Cancer Res. 2009 Feb 1;69(3):1240; author reply 1240 [19176393.001]
  • [Cites] Electrophoresis. 2000 May;21(9):1772-81 [10870964.001]
  • [Cites] Cancer Res. 2008 Mar 15;68(6):1826-33 [18339863.001]
  • [Cites] Trends Immunol. 2007 Dec;28(12):551-8 [17981503.001]
  • [Cites] N Engl J Med. 2007 Oct 25;357(17):1731-43 [17960014.001]
  • [Cites] Dig Liver Dis. 2007 Sep;39 Suppl 1:S65-71 [17936227.001]
  • [Cites] Blood. 2007 Sep 1;110(5):1550-8 [17502455.001]
  • [Cites] J Proteome Res. 2007 Jun;6(6):2232-8 [17444668.001]
  • [Cites] Clin Exp Immunol. 2007 Jun;148(3):402-9 [17335557.001]
  • [Cites] J Clin Pathol. 2006 Oct;59(10):1008-16 [17021129.001]
  • [Cites] Proteome Sci. 2006;4:16 [16948843.001]
  • [Cites] Mol Cancer Res. 2006 Sep;4(9):645-53 [16940161.001]
  • [Cites] Curr Opin Clin Nutr Metab Care. 2005 Jul;8(4):445-9 [15930972.001]
  • [Cites] Apoptosis. 2005 Mar;10(2):267-75 [15843888.001]
  • [Cites] Pharmacol Res. 2005 Feb;51(2):85-94 [15629253.001]
  • [Cites] Eur J Gastroenterol Hepatol. 1999 Oct;11(10):1185-94 [10524652.001]
  • [Cites] Gastroenterology. 1998 Sep;115(3):551-63 [9721152.001]
  • [Cites] Gastroenterology. 1997 Dec;113(6):1906-15 [9394730.001]
  • [Cites] Gut. 1991 Jan;32(1):29-35 [1991635.001]
  • [Cites] Biochem Biophys Res Commun. 2003 Feb 7;301(2):583-90 [12565903.001]
  • [Cites] Proteomics. 2002 Dec;2(12):1682-98 [12469338.001]
  • [Cites] J Immunol. 2002 Mar 15;168(6):2795-802 [11884448.001]
  • [Cites] Gut. 2002 Feb;50(2):235-40 [11788566.001]
  • [Cites] Gut. 2002 Feb;50(2):218-23 [11788563.001]
  • [Cites] Proteomics. 2001 Jun;1(6):756-62 [11677781.001]
  • [Cites] Electrophoresis. 2000 May;21(9):1787-813 [10870966.001]
  • [Cites] Electrophoresis. 2000 May;21(9):1782-6 [10870965.001]
  • [Cites] Cell Res. 2008 Apr;18(4):452-7 [18379591.001]
  • (PMID = 19298663.001).
  • [ISSN] 1477-5956
  • [Journal-full-title] Proteome science
  • [ISO-abbreviation] Proteome Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2667413
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2. Liu FY, Qi JP, Xu FL, Wu AP: Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor. World J Gastroenterol; 2006 Jul 14;12(26):4161-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor.
  • AIM: To investigate the clinicopathological features of gastrointestinal stromal tumor (GIST) and to study the reference indexes for malignancy.
  • METHODS: Fifty-two cases of primary GIST were distinguished from a group of gastrointestinal mesenchymal tumors using a panel of antibodies such as CD117 and CD34 by immunohistochemical SP method.
  • RESULTS: Grossly, the tumor size was between 1.5 cm and 13 cm (mean: 5.5 cm).
  • Focal areas of hemorrhage, necrosis, or small cyst formation could be seen.
  • Microscopically, the tumor was composed of spindle cells (20 cases), epithelioid cells (20 cases) and mixed cells (12 cases).
  • In normal adult stomach and intestine, the immunoreactive staining for CD117 and CD34 showed immunoreactive interstitial cells of Cajal in myenteric neuroplexus.
  • Expression of p21WAF1 and Bax plays an important role in potential malignancy and malignancy rather than in benign GIST. p21WAF1 and Bax may be used as the markers in the assessment of GIST malignant potential.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Gastrointestinal Stromal Tumors / metabolism. bcl-2-Associated X Protein / metabolism
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / genetics. Antigens, CD34 / metabolism. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Gene Expression Regulation, Neoplastic. Genetic Markers. Humans. Immunohistochemistry. Middle Aged. Prognosis. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism

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  • [Cites] Zhonghua Wai Ke Za Zhi. 2002 Apr;40(4):277-9 [12133359.001]
  • [Cites] Zhonghua Bing Li Xue Za Zhi. 2002 Feb;31(1):20-5 [11955330.001]
  • [Cites] Zhonghua Bing Li Xue Za Zhi. 2002 Jun;31(3):199-203 [12475434.001]
  • [Cites] Mol Cancer Ther. 2002 Jun;1(8):639-49 [12479224.001]
  • [Cites] Eur J Cancer. 2002 Sep;38 Suppl 5:S39-51 [12528772.001]
  • [Cites] Bull Cancer. 2003 Jan;90(1):69-76 [12609807.001]
  • [Cites] J Clin Pathol. 2003 May;56(5):363-7 [12719457.001]
  • [Cites] J Clin Pathol. 2003 Sep;56(9):699-702 [12944556.001]
  • [Cites] Jpn J Clin Oncol. 2003 Jul;33(7):346-52 [12949061.001]
  • [Cites] J Clin Oncol. 2003 Sep 15;21(18):3391-401 [12885834.001]
  • [Cites] Cancer Invest. 2004;22(1):106-16 [15069768.001]
  • [Cites] Swiss Med Wkly. 2004 Mar 20;134(11-12):145-53 [15106018.001]
  • [Cites] Hypertens Res. 2004 Apr;27(4):283-91 [15127886.001]
  • [Cites] Clin Cancer Res. 2004 May 1;10(9):3076-81 [15131046.001]
  • [Cites] Korean J Gastroenterol. 2004 Jun;43(6):341-8 [15220551.001]
  • [Cites] Am J Surg Pathol. 1983 Sep;7(6):507-19 [6625048.001]
  • [Cites] Mod Pathol. 1993 Mar;6(2):139-44 [8483884.001]
  • [Cites] Hypertension. 1998 Jan;31(1 Pt 2):493-8 [9453351.001]
  • [Cites] Hum Pathol. 1998 Aug;29(8):820-5 [9712423.001]
  • [Cites] Pathol Res Pract. 1998;194(10):685-91 [9820864.001]
  • [Cites] Diagn Cytopathol. 2000 Sep;23(3):156-60 [10945901.001]
  • [Cites] Clin Cancer Res. 2000 Aug;6(8):3131-8 [10955794.001]
  • [Cites] Arch Pathol Lab Med. 2000 Oct;124(10):1471-5 [11035578.001]
  • [Cites] J Surg Res. 2001 Feb;95(2):92-8 [11162031.001]
  • [Cites] Zhonghua Zhong Liu Za Zhi. 1999 Mar;21(2):99-101 [11776868.001]
  • [Cites] Zhonghua Zhong Liu Za Zhi. 2001 May;23(3):214-6 [11783089.001]
  • [Cites] J Clin Oncol. 2002 Feb 1;20(3):811-6 [11821465.001]
  • [Cites] Oncol Rep. 2002 Nov-Dec;9(6):1277-82 [12375034.001]
  • (PMID = 16830365.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Genetic Markers; 0 / bcl-2-Associated X Protein; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ PMC4087364
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3. Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M: Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol; 2005 Sep 7;11(33):5226-8
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  • [Title] Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report.
  • Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract.
  • Although rare, it is the most common primary tumor of the mesentery and can develop at any age.
  • We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST).
  • This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall.
  • Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor STI571 (imatinib mesylate) has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 16127758.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320401
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4. Yimyaem P, Saranrittichai S, Sinawat P, Dhiensiri T: Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant. J Med Assoc Thai; 2009 Jan;92(1):114-9
MedlinePlus Health Information. consumer health - Small Intestine Disorders.

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  • [Title] Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant.
  • Benign intestinal tumors are rare in children; however, the authors describe an inflammatory myofibroblastic tumor (IMT) of the terminal ileum in a 2-month-old infant who presented with an intestinal obstruction.
  • A review of the literature for this rare condition was done to delineate the natural history of this tumor and to do a histological confirmation of its benign nature.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Ileal Diseases / pathology. Intestinal Obstruction / pathology

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  • (PMID = 19260252.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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5. Robertson RG, Geiger WJ, Davis NB: Carcinoid tumors. Am Fam Physician; 2006 Aug 1;74(3):429-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumors.
  • Carcinoid tumors are rare, slow-growing neuroendocrine neoplasms that often are indolent and may not become clinically apparent until there has been metastatic spread or evidence of carcinoid syndrome.
  • Recent evidence has revealed that the overall incidence of carcinoid tumors has been steadily increasing, and although the disease was thought to be relatively benign, it is now considered one of increasing malignancy.
  • Carcinoid tumors derive from different embryonic divisions of the gut: foregut carcinoid tumors commonly originate in the lungs, bronchi, or stomach; midgut carcinoid tumors in the small intestine, appendix, or proximal large bowel; and hindgut carcinoid tumors in the distal colon or rectum.
  • Carcinoid syndrome, although rare, is most associated with midgut carcinoid tumors.
  • The diagnosis of a carcinoid tumor often is coincidental with surgery performed for another reason.
  • Treatment and prognosis are dependent on the location of the primary tumor and the degree and extent of metastasis at the time of diagnosis.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Digestive System Neoplasms / diagnosis. Respiratory Tract Neoplasms / diagnosis

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  • (PMID = 16913162.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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6. Ishizuka M, Nagata H, Takagi K, Horie T, Abe A, Kubota K: Rectal angiolipoma diagnosed after surgical resection: a case report. World J Gastroenterol; 2007 Jan 21;13(3):467-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiolipoma is a common benign tumor with a characteristic vascular component that usually occurs in subcutaneous tissue.
  • Although lipomas are frequently encountered at colonoscopy as submucosal tumors, angiolipomas are rarely found in the gastrointestinal tract including the large intestine.
  • Here we report a 77-year old Japanese man who underwent transanal resection of a tumor that was diagnosed tentatively as a leiomyoma.
  • Histologically, the tumor consisted of mature fat cells and blood vessels.
  • Immunohistochemically, the tumor cells were negative for c-kit and HMB-45, which are consistently expressed in tumors such as gastrointestinal stromal tumor and angiomyolipoma.
  • The tumor was therefore diagnosed as an angiolipoma.
  • [MeSH-major] Angiolipoma / diagnosis. Rectal Neoplasms / diagnosis

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  • [Cites] Dig Surg. 1999;16(5):441-4 [10567811.001]
  • [Cites] Acta Gastroenterol Belg. 1964 Dec;27:750-7 [14305925.001]
  • [Cites] Radiol Med. 2000 Nov;100(5):343-7 [11213412.001]
  • [Cites] Chirurg. 2001 Mar;72(3):305-7 [11317452.001]
  • [Cites] Gastrointest Endosc. 2002 May;55(6):748-50 [11979266.001]
  • [Cites] Dis Colon Rectum. 2003 Apr;46(4):547-9 [12682553.001]
  • [Cites] Abdom Imaging. 2003 Jul-Aug;28(4):515-7 [14580094.001]
  • [Cites] Endoscopy. 2004 Apr;36(4):375 [15057700.001]
  • [Cites] Surg Endosc. 1989;3(2):106-8 [2788928.001]
  • [Cites] Radiology. 1990 Jun;175(3):737-8 [2343124.001]
  • [Cites] Gastrointest Endosc. 1990 Sep-Oct;36(5):435-8 [2227312.001]
  • [Cites] Eur J Surg. 1991 Jan;157(1):51-5 [1675882.001]
  • [Cites] Am J Med Sci. 1993 Apr;305(4):229-35 [8475948.001]
  • [Cites] Nihon Shokakibyo Gakkai Zasshi. 1996 Apr;93(4):260-5 [8656569.001]
  • [Cites] Minerva Chir. 1996 Jan-Feb;51(1-2):59-62 [8677048.001]
  • [Cites] Am J Gastroenterol. 1996 Sep;91(9):1852-4 [8792714.001]
  • [Cites] Aust N Z J Surg. 1996 Oct;66(10):713-5 [8855930.001]
  • [Cites] Arch Dermatol. 1960 Dec;82:924-31 [13716236.001]
  • [Cites] Gastroenterol Clin Biol. 2000 Jun-Jul;24(6-7):686-8 [10962400.001]
  • (PMID = 17230621.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4065907
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7. Otomi Y, Otsuka H, Morita N, Terazawa K, Harada M, Nishitani H: A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor. J Med Invest; 2009 Feb;56(1-2):76-9
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  • [Title] A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor.
  • Other subcutaneous masses considered benign and neurogenic in nature also showed FDG uptake (SUVmax around 3 or less), but the degree of FDG uptake differed considerably from the left femoral mass.
  • Incidentally, PET/CT also showed an asymptomatic large abdominal mass with intense FDG uptake (SUVmax 8.8).
  • The abdominal mass was resected and confirmed as gastrointestinal stromal tumor (GIST) of the small intestine.
  • Three months later, the left femoral mass was operated on and pathologically diagnosed as a malignant peripheral nerve sheath tumor (MPNST).
  • We present a rare case of a patient with vRd with a MPNST of the left femur and coincidental GIST of the small intestine.
  • [MeSH-major] Bone Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Intestinal Neoplasms / complications. Nerve Sheath Neoplasms / complications. Osteitis Fibrosa Cystica / complications
  • [MeSH-minor] Femur / radiography. Femur / radionuclide imaging. Fluorodeoxyglucose F18. Humans. Intestine, Small / radiography. Intestine, Small / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19262018.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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8. Emanuel P, Qin L, Harpaz N: Calcifying fibrous tumor of small intestine. Ann Diagn Pathol; 2008 Apr;12(2):138-41
MedlinePlus Health Information. consumer health - Intestinal Cancer.

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  • [Title] Calcifying fibrous tumor of small intestine.
  • Calcifying fibrous tumor (CFT) is a rare benign tumor with a predilection for children and young adults that usually arises in the subcutaneous and deep soft tissues, pleura, or peritoneum.
  • Calcifying fibrous tumor of the gastrointestinal tract is exceedingly rare and therefore prone to confusion with other spindle cell lesions more commonly encountered in this location.
  • We describe 4 cases of calcifying fibrous tumor arising in the terminal ileum, one of which caused the heretofore unreported complication of intestinal intussusception, and discuss the differential diagnosis with other common and uncommon spindle cell lesions.
  • [MeSH-major] Calcinosis / pathology. Fibroma / pathology. Ileal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibromatosis, Aggressive / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Humans. Male

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  • (PMID = 18325476.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Zhang L, Chen YJ, Shang CZ, Zhong F, Zhang HW, Chen JS: [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Jul;10(4):356-8

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  • [Title] [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases].
  • OBJECTIVE: To summarize the pathological classification, clinical symptom and experience in the diagnosis and treatment of primary tumor of small intestine.
  • METHODS: Data of 58 patients with primary tumor of small intestine pathologically confirmed from Oct.
  • RESULTS: Thirteen patient (22.4%) had primary benign tumors of small intestine and 45 patient (77.6%) had primary malignant tumors of small intestine.
  • The major clinical signs of primary tumor of small intestine included hemorrhage(85%), abdomen pain(19%), abdomen mass and intestine obstruction(16%).
  • CONCLUSIONS: Primary tumors of small intestine are difficult to be diagnosed preoperatively.
  • Laparotomy of abdominal cavity is the main choice for those patients with suspicious tumor of small intestine.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 17659462.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Biermann K, Heukamp LC, Büttner R, Zhou H: Uterine tumor resembling an ovarian sex cord tumor associated with metastasis. Int J Gynecol Pathol; 2008 Jan;27(1):58-60
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  • [Title] Uterine tumor resembling an ovarian sex cord tumor associated with metastasis.
  • Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are very rare, usually benign uterine tumors, and are probably derived from uterine mesenchymal stem cells.
  • Four years after a diagnosis of UTROSCT of the uterine corpus, the patient developed obstructive ileus due to a large infiltrating tumor within the small bowel with the same morphology and expression pattern as the previously diagnosed UTROSCT.
  • In addition, 2 benign gastrointestinal stromal tumors were detected in the same patient.
  • This case indicates that although the majority of UTROSCT are benign tumors, some of them might undergo malignant transformation and have a metastatic potency.
  • [MeSH-major] Intestinal Neoplasms / secondary. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology. Humans. Immunohistochemistry. Intestinal Obstruction / etiology. Intestine, Small / metabolism. Intestine, Small / pathology. Neoplasms, Second Primary / metabolism. Neoplasms, Second Primary / pathology

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  • (PMID = 18156976.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • [Title] A shift in the diagnostics of the small intestine tumors.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • METHODOLOGY: A retrospective study comprising 96 patients having undergone surgery for a small intestine tumor in our hospital from 1996 to 2005 is presented.
  • In the year 1998 we changed our philosophy in trying to directly detect the small intestine pathology and not making the diagnosis by the exclusion only.
  • Intestinal ultrasound was performed on the Ultramark 3000 HDI device with autofocussable convex 5 MHz and linear 7.5 MHz probes or nowadays ATL 5000 HDI, 7-12 MHz linear probe.
  • RESULTS: We treated surgically 96 patients with the small intestine tumor.
  • CONCLUSION: The small bowel ultrasound can be recommended as the first choice method.
  • All patients with even very moderate abdominal symptoms ought to be examined for the small intestine pathology.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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12. Uenoyama Y, Seno H, Fukuda A, Sekikawa A, Nanakin A, Sawabu T, Kawada M, Kanda N, Suzuki K, Yada N, Fukui H, Chiba T: Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway. Oncogene; 2006 Jun 1;25(23):3277-85
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  • [Title] Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway.
  • Cyclooxygenase-2 (COX-2) plays important roles in tumor development.
  • Especially in the early-stage colorectal tumors, COX-2 expression is often observed in the tumor stroma.
  • In the present study, we simulated the indirect interaction between epithelial cells and stromal cells in the process of colorectal tumor development using an in vitro co-culture model in which NIH3T3 fibroblasts were co-cultured with 'sparsely' or 'densely' populated intestinal epithelial cells, Intestine-407 as a model of premalignant or benign intestinal epithelial cells, and DLD-1 and Caco-2 as models of malignant epithelial cells.
  • Interestingly, there was pericellular hypoxia in the vicinity of NIH3T3 fibroblasts when co-cultured with 'dense' epithelial cells, and the recovery of the partial pressure of oxygen level resulted in the reduction of enhanced COX-2 expression only in NIH3T3 fibroblasts co-cultured with 'dense' Intestine-407 cells.
  • Thus, pericellular hypoxia of the stromal cells caused by densely populated epithelial cells may be one of the potent COX-2 enhancers before completion of malignant transformation during intestinal tumor development.
  • [MeSH-major] Anoxia / enzymology. Cyclooxygenase 2 / biosynthesis. Intestinal Mucosa / cytology. Intestinal Mucosa / enzymology. Membrane Proteins / biosynthesis. Signal Transduction / physiology. Transcription Factor AP-1 / physiology
  • [MeSH-minor] Animals. Caco-2 Cells. Cell Count. Cell Line, Tumor. Coculture Techniques. Enzyme Induction / physiology. Humans. Mice. NIH 3T3 Cells. Precancerous Conditions / enzymology. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Stromal Cells / enzymology. Stromal Cells / pathology

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  • (PMID = 16407821.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Transcription Factor AP-1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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13. Chen CY, Lin XZ, Wu HC, Shiesh SC: The value of biliary amylase and Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in diagnosing biliary malignancies. Clin Biochem; 2005 Jun;38(6):520-5
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  • [Title] The value of biliary amylase and Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in diagnosing biliary malignancies.
  • BACKGROUND/OBJECTIVES: Elevated concentrations of Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in pancreatic juice have been reported in patients with pancreatic adenocarcinoma and have been considered as a promising tumor marker.
  • At a cut-off value of 46 U/L, the biliary amylase distinguished patients with malignant obstruction from those with benign obstruction with a sensitivity of 66% and a specificity of 74%.
  • The divergent extent and duration of biliary obstruction caused by neoplasm and gallstones may contribute to the significant difference in the amylase activity in bile.
  • [MeSH-major] Amylases / analysis. Antigens, Neoplasm / analysis. Bile / enzymology. Bile Duct Neoplasms / diagnosis. Biomarkers, Tumor / analysis. Lectins, C-Type / analysis
  • [MeSH-minor] Biliary Tract Diseases / diagnosis. Diagnosis, Differential. Female. Humans. Male. Retrospective Studies. Taiwan

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  • (PMID = 15885230.001).
  • [ISSN] 0009-9120
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Lectins, C-Type; 0 / pancreatitis-associated protein; EC 3.2.1.- / Amylases
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14. Fukumoto A, Tanaka S, Shishido T, Oka S, Chayama K: [Diagnosis and treatment for benign small bowel tumor]. Nihon Rinsho; 2008 Jul;66(7):1305-11

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  • [Title] [Diagnosis and treatment for benign small bowel tumor].
  • Even if small bowel tumors are benign, they need to be treated when they cause symptoms, such as gastrointestinal bleeding or enteric intussusception.
  • It became possible to perform endoscopic treatment for small bowel lesions using DBE.
  • Therefore for preventing surgical operation, it became important to detect small bowel tumors while endoscopic treatment is possible.
  • CE has potential to survey small bowel tumors, especially in patients with polyposis.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 18616121.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 20
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15. Shah SN: Malignant gastrointestinal stromal tumor of intestine: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):357-9

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  • [Title] Malignant gastrointestinal stromal tumor of intestine: a case report.
  • Smooth muscle tumors of the alimentary tract are uncommon.
  • Cancer of small intestine comprises less than 20% of all malignant tumors.
  • He was diagnosed as a case of acute intestinal obstruction and on laparotomy an extraluminal mass was found at jejunoileal junction.
  • Histopathology revealed a malignant gastrointestinal stromal tumor (GIST) which was confirmed by immunohistochemistry.
  • The case is reported with review of literature and criteria for differentiation between benign and malignant tumors are enumerated.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology. Intestinal Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology. Male

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  • (PMID = 17883072.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 13
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16. Padula A, Chin NW, Azeez S, Resetkova E, Andriko JA, Miettinen M: Primary gastrointestinal stromal tumor of the esophagus in an HIV-positive patient. Ann Diagn Pathol; 2005 Feb;9(1):49-53
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  • [Title] Primary gastrointestinal stromal tumor of the esophagus in an HIV-positive patient.
  • We describe a rare case of malignant gastrointestinal stromal tumor (GIST) of the esophagus presenting in an HIV-positive man.
  • Not only did the tumor arise from an unusual anatomic site for GIST, namely, the esophagus, but it also had a predominant epithelioid cell morphology that is uncommon and preferentially associated with aggressive behavior.
  • This immunophenotype corresponded to that of stromal tumors arising in the more common sites like stomach and small intestine as well as to that of a reported series of esophageal GISTs in the general population.
  • Mutations of the c-kit protein was detected in the tumor, confirming previous observations.
  • This further documents that esophageal GIST and the more common benign esophageal spindle cell lesions are pathologically distinct entities and despite its rarity, esophageal GIST should be recognized by pathologists and clinicians.
  • The occurrence of this tumor in an HIV-positive patient is coincidental, and it resulted in an extremely unusual metastatic site that has not been reported for GISTs.
  • [MeSH-major] Esophageal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology. HIV Infections / pathology. Neoplasms, Complex and Mixed / secondary
  • [MeSH-minor] Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Endosonography. Epithelioid Cells / chemistry. Epithelioid Cells / pathology. Humans. Immunoenzyme Techniques. Male. Middle Aged. Proto-Oncogene Proteins c-kit / analysis

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  • (PMID = 15692952.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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17. Kelly RJ, Barrett C, Swan N, McDermott R: Metastatic phyllodes tumor causing small-bowel obstruction. Clin Breast Cancer; 2009 Aug;9(3):193-5
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  • [Title] Metastatic phyllodes tumor causing small-bowel obstruction.
  • Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas.
  • Metastases to the small intestine are extremely rare, with only 1 case of metastatic spread to the duodenum reported in the literature.
  • This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction.
  • Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems.
  • The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Ileal Neoplasms / secondary. Intestinal Obstruction / etiology. Phyllodes Tumor / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19661046.001).
  • [ISSN] 1938-0666
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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18. Zhou DH, Ji JS, Shao CX, Zheng C: [Value of spiral CT and its reconstruction technique in the diagnosis of gastrointestinal stromal tumors in the small intestine]. Zhonghua Zhong Liu Za Zhi; 2007 Sep;29(9):713-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of spiral CT and its reconstruction technique in the diagnosis of gastrointestinal stromal tumors in the small intestine].
  • OBJECTIVE: To evaluate the spiral CT and its reconstruction techniques in diagnosis and localization of gastrointestinal stromal tumor originated in the small intestine.
  • METHODS: The data of spiral CT scan and MPR, STS-MIP of 24 patients with gastrointestinal stromal tumor in the small intestine confirmed pathologically were analyzed retrospectrvely.
  • RESULTS: Of 24 cases, 1 had multiple tumor, while the other 23 had single one.
  • Seventeen of these tumors were benign and 7 malignant, with 2 in the duodenum, 12 in the jejunum and 10 in the ileum.
  • The range of tumor diameters was from 2.5 to 12 cm.
  • The main clinical characters of the tumors on the CT image:.
  • (1) The tumor of 15 cases located outside of the enteric cavity, 7 inside of the enteric cavity or presented as thicken bowel wall and 2 showed as niche sign. (2) The tumor shape of 19 cases were round-like, and 5 lobulated or irregular. (3) The tumor density of 12 cases was homegeneous, 7 heterogeneous and 5 map-like in the center. (4) The tumor enhancement style in 19 cases were homegeneous in dynamic enhanced scan, and 16 were slightly or mildly heterogeneous in the artery phase but apparently enhanced in the venous and equilibrium phase, with 5 showed as fast-in fast-out enhanced mode.
  • Of those, one showed obvious enhancement in artery phase, while 2 did not. (5) The tumor of 2 cases had no clear margin and had invaded the surrounding tissue. (6) The arteries supplying tumors in 20 cases were demonstrated by multiple planar reconstruction (MPR), sliding thin slab-maximum intensity projection (STS-MIP).
  • The accuracy of diagnosis and localization of gastrointestinal stromal tumor in the small intestine by spiral CT scan combined with MPR, STS-MIP were 91.7% (22/24) and 95.8% (23/24), respectively.
  • CONCLUSION: Spiral CT and its reconstruction techniques (MPR, STS-MIP) can play an important role in the differential diagnosis and localization of gastrointestinal stromal tumor originated in the small intestine.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Ileal Neoplasms / diagnosis. Image Processing, Computer-Assisted / methods. Jejunal Neoplasms / diagnosis. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / radiography. Duodenum / radiography. Female. Humans. Ileum / radiography. Jejunum / radiography. Male. Middle Aged

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  • (PMID = 18246807.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Sunamak O, Karabicak I, Aydemir I, Aydogan F, Guler E, Cetinkaya S, Korman MU: An intraluminal leiomyoma of the small intestine causing invagination and obstruction: a case report. Mt Sinai J Med; 2006 Dec;73(8):1079-81
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  • [Title] An intraluminal leiomyoma of the small intestine causing invagination and obstruction: a case report.
  • Leiomyomas are mostly of benign character and are rarely seen in the gastrointestinal (GI) system.
  • They represent one subgroup of a group of tumors known as gastrointestinal stromal tumors (GIST).
  • Although rarely seen, they are symptomatic tumors, and they comprise 20-30 percent of all benign GI tumors.
  • This is a case report of intestinal leiomyoma in a patient who was suffering with GI obstruction for more than 5 months.
  • The tumor was discovered only after the appearance of intestinal obstruction.
  • [MeSH-major] Gastrointestinal Stromal Tumors / complications. Ileal Neoplasms / complications. Intussusception / etiology. Jejunal Neoplasms / complications. Leiomyoma / complications
  • [MeSH-minor] Aged. Female. Humans. Intestine, Small / pathology

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  • (PMID = 17285198.001).
  • [ISSN] 0027-2507
  • [Journal-full-title] The Mount Sinai journal of medicine, New York
  • [ISO-abbreviation] Mt. Sinai J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Coco C, Rizzo G, Manno A, Mattana C, Verbo A: Surgical treatment of small bowel neoplasms. Eur Rev Med Pharmacol Sci; 2010 Apr;14(4):327-33

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  • [Title] Surgical treatment of small bowel neoplasms.
  • Small intestinal neoplasms are uncommon cancers.
  • Benign small intestinal tumors (e.g., leiomyoma, lipoma, hamartoma, or desmoid tumor) usually are asymptomatic but may present with complications.
  • Primary malignancies of the small intestine, including adenocarcinoma, leiomyosarcoma, carcinoid, and lymphoma, are often symptomatic and may present with intestinal obstruction, jaundice, bleeding, or pain.
  • Metastatic neoplasms may involve the small intestine via contiguous spread, peritoneal metastases or hematogenous metastases.
  • Because the small intestine is relatively inaccessible to routine endoscopy, diagnosis of small intestinal neoplasms is often delayed for months after onset of symptoms.
  • During last years the increase of small bowel endoscopy and other diagnostic tools allow earlier non-operative diagnosis.
  • Even though radical resection of small bowel cancer plays an important role, the 5 yr overall survival remains low.
  • [MeSH-major] Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery. Humans. Laparoscopy. Lymphoma / pathology. Lymphoma / surgery. Neoplasm Metastasis

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  • (PMID = 20496543.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 51
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21. Xu L, Zhong F, Guo FF, Zhao WJ, Sun XR, Wei XF: [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid]. Zhonghua Bing Li Xue Za Zhi; 2008 Apr;37(4):243-9
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  • [Title] [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid].
  • To compare the expression differences of motilin and it precursor mRNA between normal thyroid and intestines.
  • To study the expression of motilin and its precursor mRNA in human thyroid tumors and their clinical implications.
  • METHODS: RT-PCR, Southern blot and molecular cloning were used to detect motilin transcript expression in human thyroid and mucous membrane of small intestine.
  • (1) The expression of motilin and its precursor mRNA in normal human thyroid was primarily in the thyroid C cells. (2) RT-PCR and Southern blot showed that motilin mRNA expressed in human thyroid was identical to that expressed in duodenum with identical sequence deposited in NCBI Genbank of America. (3) Immunohistochemistry, Western blot research and real-time PCR studies showed that motilin and its precursor mRNA were expressed in normal and tumor tissues of human thyroid.
  • Thyroid tumors (acidophilic adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter) showed intense and diffuse immunostaining for motilin peptide.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Motilin / metabolism. RNA Precursors / metabolism. RNA, Messenger / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Carcinoma, Medullary / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary / metabolism. Female. Humans. Intestines / metabolism. Male. Middle Aged. Nervous System Neoplasms / metabolism. Thyroid Gland / metabolism

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  • (PMID = 18844033.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA Precursors; 0 / RNA, Messenger; 52906-92-0 / Motilin
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22. Lin CY, Chen HY, Jwo SC, Chan SC: Ileal angiomyolipoma as an unusual cause of small-intestinal intussusception. J Gastroenterol; 2005 Feb;40(2):200-3
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  • [Title] Ileal angiomyolipoma as an unusual cause of small-intestinal intussusception.
  • Angiomyolipomas are benign mesenchymal tumors, but those that arise from the small intestine are exceedingly rare.
  • Small-bowel intussusception was shown on an abdominal computed tomography (CT) scan.
  • We discuss the clinical manifestations and clinicopathological and immunohistochemical findings of this benign tumor which appeared in this rare location.
  • [MeSH-major] Angiomyolipoma / complications. Ileal Neoplasms / complications. Intussusception / etiology

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  • (PMID = 15770405.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Desmin
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23. Soga J: [The life of S. Oberndorfer: the proposer of the term "carcinoid"--the outcome of a seed in the past 100 years]. Nihon Rinsho; 2009 Nov;67(11):2201-6
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  • In 1876, he was born at Munich and, in 1907 reported a series of 6 cases of "carcinoids" in the small intestine as benign tumorlets.
  • A proposal of the concept of GEP system in 1973 was followed by proposals of the concept of neuroendocrine tumor (NET) and the GEP-NET classification based on the WHO histological classification, later developing into the TNM classification by the ENETS (European NET Society), which was founded in 2004.
  • Carcinoids are now included in a corner of the GEP-NET classification with a somewhat confusing expression of "benign biological(clinical) behavior" vs. histological malignancy.
  • [MeSH-major] Carcinoid Tumor / history

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  • (PMID = 19899541.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Biography; English Abstract; Historical Article; Journal Article
  • [Publication-country] Japan
  • [Personal-name-as-subject] Oberndorfer S
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24. Hobson ML, Johari AS, Woon W, Haghighi KS: Mesenteric panniculitis causing ischemic bowel: a case report. Int Surg; 2008 Jul-Aug;93(4):238-40
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  • This is the first publication of a rare benign tumor; mesenteric panniculitis causing acute on chronic ischemic bowel injury.
  • [MeSH-major] Intestine, Small / blood supply. Ischemia / etiology. Panniculitis, Peritoneal / complications

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  • (PMID = 19731860.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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25. Zang L, Hu WG, Yan XW, Zhang T, Ma JJ, Ye Q, Feng B, Wang ML, Lu AG, Li JW, Zhong J, Zheng MH: Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A; 2010 Jul-Aug;20(6):521-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment for small intestinal bleeding: a report of 77 cases.
  • BACKGROUND: Morbidity of small intestinal disease is rare and the associated lesion is hard to be detected due to lack of specific manifestations and effective diagnostic approaches.
  • Hematochezia and melena are the most common symptoms in small intestinal diseases.
  • Hence, small intestinal disease is an important differential diagnosis when hematochezia or melena occurs, especially when gastric and colonic diseases are excluded.
  • As the small intestinal lesion is hard to be located preoperatively, laparotomy used to be performed without a preoperative location.
  • With the development of laparoscopic technique, laparoscopic operations are more frequently applied to surgical disease, despite their benign or malignant nature.
  • Generally, almost all kinds of small intestinal disease can be treated with laparoscopic surgery.
  • METHODS: Clinical data of 77 patients with small intestinal bleeding undergoing laparoscopic or laparoscopy-assisted operations from April 2003 to December 2008 were included, and their clinical information were analyzed retrospectively.
  • There was 1 case of gastrointestinal stromal tumor with local recurrence and hepatic metastasis.
  • Four patients died from metastasis of malignant tumors during the follow-up from 2 to 70 months after operations.
  • CONCLUSIONS: Laparoscopic treatment in small intestinal bleeding is feasible, safe, and minimally invasive.
  • It may be widely used in the future for its good therapeutic outcomes and improved diagnostic chance in small intestinal bleeding diseases.
  • [MeSH-major] Gastrointestinal Hemorrhage / surgery. Intestine, Small. Laparoscopy
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Loss, Surgical. Female. Humans. Intestinal Neoplasms / diagnosis. Length of Stay. Male. Melena / diagnosis. Middle Aged. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):771 [20874417.001]
  • (PMID = 20687815.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Yu DC, Javid PJ, Chikwava KR, Kozakewich HP, Debiec-Rychter M, Lillehei CW, Weldon CB: Mesenteric lipoblastoma presenting as a segmental volvulus. J Pediatr Surg; 2009 Feb;44(2):e25-8
MedlinePlus Health Information. consumer health - Intestinal Obstruction.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mesenteric lipoblastoma is a rare tumor and, its presentation as a bowel obstruction with possible midgut volvulus has only been reported once before.
  • A 7-year-old girl presented with nausea and vomiting but a benign abdominal examination.
  • During emergency laparotomy, segmental small bowel volvulus secondary to a large mesenteric lipoblastoma was found.
  • The lipoblastoma was resected with a segment of small bowel.
  • Resection margins were negative for tumor, and the patient is doing well with no evidence of recurrence.
  • [MeSH-major] Intestinal Obstruction / etiology. Intestinal Volvulus / etiology. Intestine, Small. Mesentery. Peritoneal Neoplasms / complications

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  • (PMID = 19231517.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Mortuaire G, Pasquesoone X, Leroy X, Chevalier D: Respiratory epithelial adenomatoid hamartomas of the sinonasal tract. Eur Arch Otorhinolaryngol; 2007 Apr;264(4):451-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Respiratory epithelial adenomatoid hamartomas of the sinonasal tract.
  • We report the clinicopathologic features of two cases of respiratory epithelial adenomatoid harmartoma (REAH) of the sinonasal tract.
  • The two patients were evaluated by a gastroenterologist to assess intestine colocalization.
  • Fine histopathological analysis is necessary to avoid aggressive surgery for this benign lesion.
  • [MeSH-major] Adenomatoid Tumor / pathology. Hamartoma / pathology. Paranasal Sinus Neoplasms / pathology. Respiratory Mucosa / pathology
  • [MeSH-minor] Adult. Endoscopy. Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17089137.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Hornick JL, Fletcher CD: Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol; 2005 Jul;29(7):859-65
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  • [Title] Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.
  • Benign peripheral nerve sheath tumors are uncommon in the gastrointestinal tract, and perineuriomas have not previously been reported to occur at this anatomic location.
  • In this study, we analyzed the clinicopathologic and immunohistochemical features of 10 perineuriomas arising in the intestine.
  • Eight of the lesions were intramucosal perineuriomas presenting as small sessile polyps detected during colonoscopy; 6 of these 8 patients were asymptomatic and undergoing colorectal cancer screening.
  • The colonic submucosal tumor was microscopically well circumscribed, whereas the jejunal perineurioma showed focal infiltration through the muscularis propria into the subserosa.
  • The stroma was collagenous in the colonic tumor and predominantly myxoid in the jejunal tumor.
  • All tumors except one were positive for epithelial membrane antigen (EMA); 4 of 10 expressed claudin-1 and 2 of 10 expressed CD34.
  • All tumors were negative for S-100 protein, glial fibrillary acidic protein, neurofilament protein, smooth muscle actin, desmin, caldesmon, KIT, and pan-keratin.
  • Electron microscopy was performed on the tumor lacking EMA expression, revealing typical features of perineurioma, namely, spindle cells with long bipolar cytoplasmic processes and prominent pinocytotic vesicles, surrounded by discontinuous basal lamina.
  • No tumor recurred.
  • In summary, perineuriomas may arise in the intestine, most often as intramucosal lesions detected as colorectal polyps with distinctive histologic features including entrapment of colonic crypts.
  • Distinguishing perineuriomas from other spindle cell neoplasms of the gastrointestinal tract can be facilitated by immunostaining for EMA and claudin-1.
  • [MeSH-major] Intestinal Neoplasms / pathology. Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2006 Oct;30(10):1337-9 [17001168.001]
  • (PMID = 15958849.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 26
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29. Isobe K, Hata Y, Sakaguchi S, Takai Y, Shibuya K, Takagi K, Homma S: [The role of positron emission tomography in the detection of incidental gastrointestinal tract lesions in patients examined for lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2010 Jul;48(7):482-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The role of positron emission tomography in the detection of incidental gastrointestinal tract lesions in patients examined for lung cancer].
  • The purpose of this study was to clarify the clinical characteristics of lung cancer patients with abnormal accumulation in the gastrointestinal tract by fluoro-2-deoxyglucose positron emission tomography (PET).
  • Of the 968 consecutive patients with primary lung cancer who underwent PET from October 2005 through September 2009, 26 patients had local abnormal accumulation in the gastrointestinal tract.
  • We retrospectively compared the localization of abnormal accumulation in the gastrointestinal tract, standardized uptake value (SUV) max (1 hour), and the final clinical diagnosis.
  • The site of abnormal accumulation was the esophagus in 1 case, the stomach in 8 and the small intestine to large intestine in 17.
  • In 15 out of 26 (57%) cases with true PET positive results, there was esophageal cancer in 1 case, gastric cancer in 2, gastrointestinal stromal tumor in 1, colon cancer in 8, and 1 each of metastasis to the stomach, small intestine and large intestine from lung cancer.
  • There were no differences in mean SUV max among malignant lesions, benign lesions, and normal physiologic accumulation.
  • We should perform endoscopy of the digestive tract to detect malignant lesions with high incidence rates when PET shows localalized abnormal accumulation in the gastrointestinal, tract in patients with lung cancer.
  • [MeSH-major] Gastrointestinal Neoplasms / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Neoplasms, Multiple Primary / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 20684209.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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30. McCluggage WG: Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol; 2010 Mar;17(2):122-9
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  • [Title] Mullerian adenosarcoma of the female genital tract.
  • Mullerian adenosarcoma is an uncommon, but not rare, mixed tumor containing a neoplastic but benign or mildly atypical epithelial element and a sarcomatous, usually low-grade, stromal component.
  • The most common site is the uterine corpus but adenosarcoma also occurs in the cervix and ovary and more rarely in the vagina, fallopian tube, arising from peritoneal surfaces, or outside the female genital tract, for example in the intestine.
  • Characteristic histologic features include a low power "phyllodes-like" architecture with leaf-like projections lined by a variety of benign Mullerian type epithelia, sometimes with squamous metaplasia.
  • Uterine adenosarcomas are, in general, low-grade neoplasms capable of local recurrence after polypectomy or hysterectomy and much less commonly distant metastasis.
  • Adenosarcoma may be confused with a variety of lesions and one of the main differential diagnoses is adenofibroma in which the stromal component is, by definition, morphologically benign.
  • [MeSH-major] Adenosarcoma / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adenofibroma / pathology. Aged. Aged, 80 and over. Female. Humans. Ovarian Neoplasms / pathology. Postmenopause. Uterine Cervical Neoplasms / pathology

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  • (PMID = 20179434.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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31. Sugár I, Forgács B, István G, Bognár G, Sápy Z, Ondrejka P: Gastrointestinal stromal tumors (GIST). Hepatogastroenterology; 2005 Mar-Apr;52(62):409-13
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  • [Title] Gastrointestinal stromal tumors (GIST).
  • BACKGROUND/AIMS: Gastrointestinal stromal tumors (GIST) are the most frequent non-epithelial tumors of the alimentary tract.
  • GIST's occur throughout the gastrointestinal tract but are generally located in the stomach and the intestine.
  • The tumor size, mitotic rate, cellularity and nuclear pleomorphism are the most important parameters characterizing the biological behavior of tumors.
  • The diagnostic procedures are similar to those of other gastrointestinal neoplasms but only a half of the patients will have correct preoperative histological diagnosis.
  • RESULTS: All but one proved to be benign.
  • CONCLUSIONS: GIST is a rare neoplasm of the GI tract.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Incidental Findings. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 15816446.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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32. Czeczot H, Scibior-Bentkowska D, Skrzycki M, Majewska M, Podsiad M: [Lipid peroxidation level in gastrointestinal tract tumors]. Pol Merkur Lekarski; 2010 Nov;29(173):309-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lipid peroxidation level in gastrointestinal tract tumors].
  • Oxygen free radicals and their reactive derivatives participate in formation of chronic inflammation states, which facilitate development of gastrointestinal tract tumors.
  • The aim of the study was the determination of lipid peroxidation level in gastrointestinal tract tumors (stomach, liver, colon, and colorectal cancer to liver metastases).
  • MATERIAL AND METHODS: Materials for studies were obtained from 150 patients with gastrointestinal tract tumors: 10 with stomach cancer, 30 with malignant and benign liver cancers, 60 with primary colorectal cancer, and 50 with metachronous colorectal cancer liver metastases.
  • Tumor specimens, and normal adjacent tissues (6-7 cm from the edge of the tumor), which served as control tissue in studies, were collected from patients (with their consent) during surgery.
  • RESULTS: The study showed the highest concentration of TBARS in benign, and the lowest in malignant liver tumors.
  • Other types of gastrointestinal tumors studied, were characterized by similar levels of lipid peroxidation.
  • TBARS concentration in these tumors was approximately 2-fold higher than in malignant liver tumors and much lower than in benign tumors.
  • In all cancers of the digestive tract with the exception of malignant liver tumors increased level of TBARS was found, comparing with control tissue.
  • The level of lipid peroxidation in liver cirrhosis and malignant liver tumors was similar.
  • There were no significant differences in TBARS concentration in the tumors of particular sections of the intestine and normal colon.
  • CONCLUSIONS: The level of lipid peroxidation in cancerous cells of gastrointestinal tract indicates increased oxidative stress.
  • The changes of lipid peroxidation level--a marker of oxidative stress in gastrointestinal tumors appear to be closely associated with their development stages (liver cirrhosis/malignant liver cancer; colorectal cancer/colorectal cancer liver metastases) and are likely to create such conditions, in which cancerous cells may proliferate, undergo gradual dedifferentiation and malignancy, and generate metastases.
  • [MeSH-major] Gastrointestinal Neoplasms / metabolism. Lipid Peroxidation. Liver Neoplasms / secondary

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  • (PMID = 21268915.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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33. Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK: Prevalence and management of gastrointestinal stromal tumors. Am Surg; 2009 Jan;75(1):55-60
Genetic Alliance. consumer health - Gastrointestinal Stromal Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence and management of gastrointestinal stromal tumors.
  • The prevalence and characteristics of patients with confirmed gastrointestinal stromal tumor (GIST) in a community hospital over a 6-year period are described.
  • Our objective was to communicate our experience managing this rare tumor of the gastrointestinal tract.
  • Patients with a diagnosis of GIST, cells of Cajal tumor, and/or different varieties of gastrointestinal sarcoma were included in this study.
  • These tumors had to have a positive C-kit on immunohistochemistry.
  • The most common clinical presentation was an intra-abdominal nonobstructing mass followed by an endoscopically detected mass or incidental tumors found during unrelated surgery.
  • Over half of these tumors were located in the stomach.
  • Other sites were the small intestine, colon, esophagus, and rectal-vaginal septum.
  • Only 18 per cent of these tumors were considered benign, whereas 35 per cent were considered to have some malignant potential and 47 per cent were of undetermined potential.
  • In surgically resected tumors, we found a 42 per cent recurrence rate with a median average time of recurrence of 22 months.
  • Our experience is similar to large-volume centers.
  • [MeSH-major] Gastrointestinal Stromal Tumors / epidemiology. Gastrointestinal Stromal Tumors / surgery. Hospitals, Community

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  • (PMID = 19213398.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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34. Fingleton B, Powell WC, Crawford HC, Couchman JR, Matrisian LM: A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. Hybridoma (Larchmt); 2007 Feb;26(1):22-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunostaining of MMP-7 in normal tissues or benign tumors of intestinal, breast, and prostatic origin indicates that this protein is normally localized luminally in glandular epithelium.
  • The localization pattern would suggest that in normal or early stage tumors, MMP-7 is most likely not directly involved in extracellular matrix degradation.
  • In contrast, advanced colon tumors show MMP-7 in invading cells at the advancing edge of the tumor.

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  • [Cites] Differentiation. 2002 Dec;70(9-10):561-73 [12492497.001]
  • [Cites] Curr Biol. 1999 Dec 16-30;9(24):1441-7 [10607586.001]
  • [Cites] Cancer Cell. 2005 May;7(5):485-96 [15894268.001]
  • [Cites] Science. 1999 Oct 1;286(5437):113-7 [10506557.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1402-7 [9037065.001]
  • [Cites] Prostate. 1996 Sep;29(3):159-68 [8827084.001]
  • [Cites] Int J Biochem Cell Biol. 1996 Feb;28(2):123-36 [8729000.001]
  • [Cites] Protein Expr Purif. 1994 Feb;5(1):27-36 [8167471.001]
  • [Cites] Nat Rev Immunol. 2004 Aug;4(8):617-29 [15286728.001]
  • [Cites] Gastroenterology. 2004 May;126(5):1423-47 [15131803.001]
  • [Cites] Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):119-35 [15000153.001]
  • [Cites] Am J Pathol. 2003 Jun;162(6):1831-43 [12759241.001]
  • [Cites] Circ Res. 2003 May 2;92(8):827-39 [12730128.001]
  • [Cites] J Clin Invest. 2000 Jan;105(2):143-50 [10642592.001]
  • [Cites] J Clin Invest. 2002 Jun;109(11):1437-44 [12045257.001]
  • (PMID = 17316082.001).
  • [ISSN] 1554-0014
  • [Journal-full-title] Hybridoma (2005)
  • [ISO-abbreviation] Hybridoma (Larchmt)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA60867; United States / NCI NIH HHS / CA / R01 CA84360; United States / NIAMS NIH HHS / AR / AR36457; United States / NCI NIH HHS / CA / R01 CA084360; United States / NIAMS NIH HHS / AR / P30 AR48311; United States / NIAMS NIH HHS / AR / P30 AR048311; United States / NCI NIH HHS / CA / R01 CA100126; United States / NCI NIH HHS / CA / R01 CA060867
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Enzyme Precursors; EC 3.4.24.23 / Matrix Metalloproteinase 7
  • [Other-IDs] NLM/ NIHMS403810; NLM/ PMC3838102
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35. Kala Z, Kysela P, Meluzinova H: Small-bowel tumors in the elderly 65+ years: 10 years of experience. Z Gerontol Geriatr; 2008 Oct;41(5):403-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small-bowel tumors in the elderly 65+ years: 10 years of experience.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work represents a prospective evaluation of a diagnostic and therapeutic algorithm in the management of the small-intestine tumor below the ligamentum Treitzi in patients over 65 years of age.
  • RESULTS: A population of 96 patients who underwent surgery for a small-intestinal tumor in our hospital from 1996 to 2006 is presented.
  • Ultrasound of the small intestine was sufficient to make the diagnosis in 21 of them.
  • CONCLUSION: The small-bowel ultrasound can be recommended as the first choice method.
  • All complaints regarding the gastrointestinal tract should be verified.
  • [MeSH-major] Intestinal Neoplasms / surgery. Intestinal Neoplasms / ultrasonography. Intestine, Small / surgery. Intestine, Small / ultrasonography. Ultrasonography / methods

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  • (PMID = 18327695.001).
  • [ISSN] 0948-6704
  • [Journal-full-title] Zeitschrift für Gerontologie und Geriatrie
  • [ISO-abbreviation] Z Gerontol Geriatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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36. Amosenko FA, Korchagina EL, Matveeva TI, Vaganov IuE, Vlasov SB, Poltavets NV, Veselov VV, Gar'kavtseva RF, Poliakov AV: [Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]. Genetika; 2010 May;46(5):700-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To estimate diagnostic value of K-ras mutations during cancer risk group formation, they were studied in the samples of sporadic carcinomas (n = 33) and malignant (n = 13) polyps of large intestine obtained during surgery or polypectomy.
  • Mutation frequency in carcinomas, benign and malignant polyps was 43, 49, and 69%, respectively.
  • In the healthy tissue of the large intestine, no changes in codons 12 and 13 in the K-ras gene were observed.
  • In patients with colorectal carcinoma the mutation frequency in the K-ras gene was not associated with disease onset age, location, and the extent of tumor differentiation while it was associated with the stage of tumor process.
  • The maximum mutation frequency was revealed in polyps of patients over 70 years of age as well as in the adenomas of villous histology and large size ((1 cm).
  • [MeSH-major] Adenocarcinoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Neoplasm / genetics. Genes, ras / genetics. Mutation

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  • (PMID = 20583607.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Codon; 0 / DNA, Neoplasm
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37. Fingleton B, Carter KJ, Matrisian LM: Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res; 2007 May 15;67(10):4800-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model.
  • Fas ligand (FasL/CD95L), a member of the tumor necrosis factor family, interacts with a specific receptor Fas, ultimately leading to cell death.
  • Tumor expression of FasL has been proposed to aid in immune evasion through a "Fas counterattack" mechanism but has also been described as a proinflammatory factor.
  • Here, we tested the role of FasL in a mouse model of spontaneous tumor development.
  • We used the Min mouse in which multiple benign polyps develop in the intestine due to a mutation in the Apc tumor suppressor gene.
  • Mutant mice deficient in functional FasL, termed gld/gld, were crossed to Min mice to generate tumor-prone animals lacking functional FasL.
  • There was no difference in the number of either lymphocytes or macrophages; however, the number of tumor-infiltrating neutrophils was 3-fold lower in the gld/gld specimens compared with controls.
  • In a nontumor-bearing colitis model in vivo, neutrophil recruitment to the intestine was also reduced in gld/gld mice.
  • Although the Fas counterattack hypothesis suggests that the absence of FasL would result in increased immune-mediated tumor elimination, the opposite is true in the Min model with lack of functional FasL associated with reduced neutrophil influx and increased tumor development.
  • Thus, the proinflammatory rather than counterattack role of tumor FasL is more relevant.
  • [MeSH-major] Cell Transformation, Neoplastic / immunology. Fas Ligand Protein / immunology. Intestinal Neoplasms / immunology
  • [MeSH-minor] Adenoma / genetics. Adenoma / immunology. Adenoma / pathology. Animals. Cell Movement / immunology. Disease Models, Animal. Genes, APC. Humans. Inflammation / immunology. Inflammation / pathology. Intestinal Polyps / genetics. Intestinal Polyps / immunology. Intestinal Polyps / pathology. Lymphocytes / immunology. Male. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Mutation

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  • (PMID = 17510409.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA60867
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fas Ligand Protein
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38. Levin TG, Powell AE, Davies PS, Silk AD, Dismuke AD, Anderson EC, Swain JR, Wong MH: Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology; 2010 Dec;139(6):2072-2082.e5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract.
  • BACKGROUND & AIMS: CD166 (also called activated leukocyte cell adhesion molecule [ALCAM]) is a marker of colorectal cancer (CRC) stem cells; it is expressed by aggressive tumors.
  • Although the presence of CD166 at the tumor cell surface has been correlated with shortened survival, little is known about its function and expression in normal intestinal epithelia.
  • METHODS: We characterized the expression pattern of CD166 in normal intestinal tissue samples from humans and mice using immunohistochemisty, flow cytometry, and quantitative reverse-transcriptase polymerase chain reaction.
  • Human and mouse intestinal tumors were also analyzed.
  • RESULTS: CD166 was expressed on the surface of epithelial cells within the stem cell niche and along the length of the intestine; expression was conserved across species.
  • In the small intestine, CD166 was observed on crypt-based Paneth cells and intervening crypt-based columnar cells (putative stem cells).
  • CD166 was located in the cytoplasm and at the surface of cells within human CRC tumors.
  • CD166-positive cells were also detected in benign adenomas in mice; rare cells coexpressed CD166 and CD44 or epithelial-specific antigen.
  • CONCLUSIONS: CD166 is highly expressed within the endogenous intestinal stem cell niche.
  • CD166-positive cells appear at multiple stages of intestinal carcinoma progression, including benign and metastatic tumors.
  • Further studies should investigate the function of CD166 in stem cells and the stem cell niche, which might have implications for normal intestinal homeostasis.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • [Cites] J Exp Med. 1995 Jun 1;181(6):2213-20 [7760007.001]
  • [Cites] Differentiation. 2003 Jan;71(1):28-41 [12558601.001]
  • [Cites] Am J Pathol. 1998 Mar;152(3):805-13 [9502422.001]
  • [Cites] J Bone Miner Res. 1998 Apr;13(4):655-63 [9556065.001]
  • [Cites] Nat Rev Cancer. 2003 Dec;3(12):895-902 [14737120.001]
  • [Cites] Eur J Immunol. 2004 Apr;34(4):930-40 [15048703.001]
  • [Cites] J Clin Pathol. 2004 Nov;57(11):1160-4 [15509676.001]
  • [Cites] Science. 1976 Oct 1;194(4260):23-8 [959840.001]
  • [Cites] Science. 1990 Jan 19;247(4940):322-4 [2296722.001]
  • [Cites] Exp Cell Res. 1992 Nov;203(1):91-9 [1426054.001]
  • [Cites] J Biol Chem. 1993 Aug 25;268(24):18345-58 [8349710.001]
  • [Cites] J Neurobiol. 1994 Jul;25(7):831-45 [8089660.001]
  • [Cites] J Exp Med. 1995 Apr 1;181(4):1563-8 [7535342.001]
  • [Cites] J Cell Biol. 1998 May 4;141(3):765-77 [9566975.001]
  • [Cites] J Biol Chem. 2004 Dec 31;279(53):55315-23 [15496415.001]
  • [Cites] J Cell Sci. 2005 Apr 1;118(Pt 7):1515-25 [15769845.001]
  • [Cites] Oncology. 2005;68(4-6):462-70 [16024937.001]
  • [Cites] Nature. 2006 Jan 5;439(7072):84-8 [16397499.001]
  • [Cites] J Clin Pathol. 2006 Apr;59(4):403-9 [16484444.001]
  • [Cites] FEBS Lett. 2006 May 15;580(11):2637-45 [16650408.001]
  • [Cites] J Immunol. 2006 Jul 15;177(2):877-84 [16818742.001]
  • [Cites] Med Sci Monit. 2006 Aug;12(8):BR263-73 [16865058.001]
  • [Cites] Mod Pathol. 2007 Jan;20(1):102-7 [17143262.001]
  • [Cites] Nature. 2007 Jan 4;445(7123):106-10 [17122772.001]
  • [Cites] Cancer Res. 2007 Feb 1;67(3):1030-7 [17283135.001]
  • [Cites] Development. 2007 Apr;134(8):1491-7 [17344225.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63 [17548814.001]
  • [Cites] Mol Cancer Ther. 2007 Oct;6(10):2737-46 [17938267.001]
  • [Cites] Nature. 2007 Oct 25;449(7165):1003-7 [17934449.001]
  • [Cites] Science. 2008 Jan 18;319(5861):336-9 [18202291.001]
  • [Cites] Nat Immunol. 2008 Feb;9(2):137-45 [18157132.001]
  • [Cites] Nat Cell Biol. 2008 Mar;10(3):353-60 [18264089.001]
  • [Cites] Stem Cells. 2008 Mar;26(3):630-7 [18055444.001]
  • [Cites] Clin Cancer Res. 2008 Mar 15;14(6):1726-33 [18347173.001]
  • [Cites] Cell Death Differ. 2008 Jun;15(6):947-58 [18259194.001]
  • [Cites] Curr Opin Genet Dev. 2008 Feb;18(1):48-53 [18356041.001]
  • [Cites] PLoS One. 2008;3(6):e2428 [18560594.001]
  • [Cites] Nat Genet. 2008 Jul;40(7):915-20 [18536716.001]
  • [Cites] BMC Gastroenterol. 2008;8:57 [19055726.001]
  • [Cites] Cell. 2009 Mar 6;136(5):903-12 [19269367.001]
  • [Cites] Cancer Res. 2009 Apr 15;69(8):3382-9 [19336570.001]
  • [Cites] Cell Stem Cell. 2009 May 8;4(5):427-39 [19427292.001]
  • [Cites] Nature. 2009 May 14;459(7244):262-5 [19329995.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G590-600 [20185687.001]
  • [Cites] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218.001]
  • [Cites] Am J Pathol. 2000 Mar;156(3):769-74 [10702391.001]
  • [Cites] Cancer Metastasis Rev. 2000;19(3-4):I-XI, 193-383 [11394186.001]
  • [Cites] Blood. 2001 Oct 1;98(7):2134-42 [11568000.001]
  • [Cites] J Exp Med. 2002 Jun 17;195(12):1549-63 [12070283.001]
  • [Cites] Prostate. 2003 Jan 1;54(1):34-43 [12481253.001]
  • [Cites] Blood. 1997 Apr 15;89(8):2706-16 [9108388.001]
  • (PMID = 20826154.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA118235; United States / NIDDK NIH HHS / DK / U01 DK085525-02; United States / NHLBI NIH HHS / HL / T32 HL007781; United States / NCI NIH HHS / CA / CA106195-06A1; United States / NCI NIH HHS / CA / CA118235-05; United States / NICHD NIH HHS / HD / T32 HD049309-05; United States / NCI NIH HHS / CA / CA106195; United States / NCI NIH HHS / CA / T32 CA106195; United States / NICHD NIH HHS / HD / HD049309; United States / NICHD NIH HHS / HD / T32 HD049309; United States / NCI NIH HHS / CA / T32 CA106195-06A1; United States / NHLBI NIH HHS / HL / T32 HL007781-14; United States / NIDDK NIH HHS / DK / R01 DK068326; United States / NCI NIH HHS / CA / CA118235; United States / NIDDK NIH HHS / DK / R01 DK068326-05; United States / NIDDK NIH HHS / DK / DK068326; United States / NIDDK NIH HHS / DK / DK085525-02; United States / NICHD NIH HHS / HD / HD049309-05; United States / NHLBI NIH HHS / HL / HL007781-14; United States / NHLBI NIH HHS / HL / HL007781; United States / NIDDK NIH HHS / DK / U01 DK085525; United States / NIDDK NIH HHS / DK / DK085525; United States / NIDDK NIH HHS / DK / DK068326-05; United States / NCI NIH HHS / CA / R01 CA118235-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALCAM protein, human; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules, Neuronal; 0 / Fetal Proteins
  • [Other-IDs] NLM/ NIHMS234467; NLM/ PMC2997177
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39. Galitskiĭ MV, Khomeriki SG, Nikiforov PA: [Expression of proliferation and apoptosis markers in neoplasms of colon mucosa after cholecystectomy]. Eksp Klin Gastroenterol; 2009;(5):28-32
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  • [Title] [Expression of proliferation and apoptosis markers in neoplasms of colon mucosa after cholecystectomy].
  • The cholecystectomy results in change of cholic acids flow into intestine.
  • Permanent type of the bile flow provokes the increase of proliferation of colic epithelial cells and increases the risk for development of right-sided colorectal tumors.
  • Meanwhile morphological features of colorectal tumors at the patients with cholecystectomy are still remaining to be clarified.
  • 83 tumors and 49 samples of mucosa were immunostained with monoclonal mouse anti-human p53 protein (Dako) and monoclonal mouse anti-human Ki-67 antigen (Novocastra).
  • Thus, in benign colorectal tumors at the patients with retained function of gallbladder intensifying of epithelial cells proliferation is not accompanied with intensifying of apoptosis, and in malignant tumors a complete supression of apoptosis is observed.
  • The retaining of apoptosis in colorectal tumors compensates intensive proliferative activity with expectation of better prognosis.
  • [MeSH-major] Apoptosis. Biomarkers, Tumor / biosynthesis. Cell Proliferation. Cholecystectomy. Colon / metabolism. Colonic Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Intestinal Mucosa / metabolism. Ki-67 Antigen / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 20205327.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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40. Tsushimi T, Matsui N, Kurazumi H, Takemoto Y, Oka K, Seyama A, Morita T: Laparoscopic resection of an ileal lipoma: Report of a case. Surg Today; 2006;36(11):1007-11
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  • Ultrasonography (US) showed a hyperechoic mass in the right lower abdomen, and computed tomography (CT) showed a low-density mass and intestinal invagination.
  • Thus, we made a diagnosis of intestinal lipoma with intussusception and performed laparoscopic partial resection of the ileum, including the tumor.
  • The resected specimen contained a round tumor, 25 x 22 x 20 mm, which was identified as an intestinal lipoma histopathologically.
  • Laparoscopic surgery is the treatment of choice for benign tumors of the small intestine because it is minimally invasive, with cosmetic, physical, and economic benefits.
  • [MeSH-major] Ileal Neoplasms / surgery. Laparoscopy / methods. Lipoma / surgery

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  • (PMID = 17072725.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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41. Bogner B, Péter S, Hegedus G: [Inflammatory fibroid polyp of the ileum causing intestinal invagination]. Magy Seb; 2005 Aug;58(4):237-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory fibroid polyp of the ileum causing intestinal invagination].
  • Inflammatory fibroid polyps are rare benign tumor-like lesions of the gastrointestinal tract.
  • Most frequently they are localized in the gastric antrum but can develop anywhere in the GI tract.
  • In the small intestine the ileum is the most common site, where these polyps can cause invagination and intussusception.
  • [MeSH-major] Fibroma / complications. Ileal Neoplasms / complications. Intestinal Polyps / complications. Intussusception / etiology

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  • (PMID = 16261870.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 13
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42. Garneau H, Paquin MC, Carrier JC, Rivard N: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. J Cell Physiol; 2009 Nov;221(2):350-8
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  • [Title] E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells.
  • The generation of knock-out mice for E2F4 gene expression has suggested a role for this transcription factor in establishing and/or maintaining the intestinal crypt compartment.
  • Having previously demonstrated that E2F4 is cytoplasmic in quiescent-differentiated cells but nuclear in growth factor-stimulated proliferative cells, the present study was aimed at determining the role of E2F4 in the control of human intestinal epithelial proliferation.
  • Results herein demonstrate that lentiviral infection of an shRNA which specifically knocked-down E2F4 expression slowed down G1/S phase transition and the proliferation rate of normal human intestinal epithelial cells (HIEC) and of colon cancer cells.
  • Immunofluorescence experiments in human fetal intestine revealed that cells expressing high nuclear levels of E2F4 also expressed cyclin A protein.
  • Lastly, E2F4 and its target cyclin A were up-regulated and mostly nuclear in human colorectal tumor cells in comparison to the corresponding benign epithelium.
  • These results indicate that nuclear E2F4 may be determinant in the promotion of proliferation of human intestinal epithelial crypt cells and colorectal cancer cells.
  • [MeSH-major] Cell Cycle. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. E2F4 Transcription Factor / metabolism. Intestines / cytology. Intestines / metabolism
  • [MeSH-minor] Agar. Cell Line, Tumor. Cell Nucleus / metabolism. Cell Proliferation. Cyclin A / metabolism. DNA / biosynthesis. Down-Regulation. Epithelial Cells / cytology. Epithelial Cells / metabolism. G1 Phase. Gene Expression Regulation, Neoplastic. Gene Knockdown Techniques. Humans. Protein Transport. S Phase

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  • (PMID = 19562678.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / E2F4 Transcription Factor; 0 / E2F4 protein, human; 9002-18-0 / Agar; 9007-49-2 / DNA
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43. Schwartz GD, Barkin JS: Small-bowel tumors detected by wireless capsule endoscopy. Dig Dis Sci; 2007 Apr;52(4):1026-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small-bowel tumors detected by wireless capsule endoscopy.
  • Small bowel tumors are difficult to diagnose because of their endoscopic inaccessibility.
  • The purpose of this report is to describe the largest series of patients with small bowel tumors detected by capsule endoscopy.
  • Eighty six patients were derived from the Given Imaging clinical database on a survey of Pillcam SB capsule users who were diagnosed with 87 small bowel tumors, 1 cecal tumor, and 1 gastric tumor.
  • All patients have histologically confirmed tumors.
  • Malignant tumors comprised 61% (54/89) and benign 39% (35/89).
  • Of the 87 reported small bowel tumors, 4 were identified in the duodenum, 43 tumors were identified in the jejunum, 18 tumors were identified in the ileum, and 22 tumors were located in the mid to distal small bowel.
  • The most common malignant tumors were adenocarcinoma, carcinoids, melanomas, lymphomas, and sarcomas.
  • The most common benign tumors were GIST, hemangiomas, hamartomas, adenomas, and granulation tissue polyps.
  • Capsule endoscopy is the diagnostic procedure of choice in patients with suspected small bowel tumors.
  • [MeSH-major] Capsule Endoscopy. Endoscopy, Gastrointestinal. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 17380403.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Chiu YC, Lin JW, Changchien CS, Huang CC, Liu SY, Yi LN, Chiu KW, Wu KL, Chen YY, Chou FF, Hu TH: Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors. J Formos Med Assoc; 2005 Dec;104(12):905-12

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  • [Title] Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors.
  • BACKGROUND AND PURPOSE: Gastrointestinal stromal tumors (GISTs) involving the small intestine are less common than those involving the stomach, and data on small intestinal stromal tumors (SISTs) are more limited.
  • This study investigated the clinicopathological characteristics and prognostic factors of SISTs and compared them with those of gastric stromal tumors (GSTs).
  • METHODS: A total of 82 surgically resected and pathologically diagnosed smooth muscle tumors of small bowel in patients treated from January 1986 to December 2000 were included.
  • Immunohistochemical studies were performed on these tumors with antibodies of CD117, CD34, smooth muscle actin (SMA), desmin and S-100.
  • RESULTS: Among the 82 small intestine tumors, 71 were CD117-positive (86.6%) and were classified as SISTs.
  • Survival analysis demonstrated that tumor size < 5 cm (p = 0.021), mitosis number < 5/50 high-power field (p < 0.001), SMA-positive (p = 0.027), non-epithelioid cell type (p = 0.005) and tumor with skeinoid fibers (p = 0.010) predicted longer disease-free survival after operation.
  • Multivariate analysis revealed that mitotic number (p = 0.001), cell morphology (p = 0.031) and tumor size (p = 0.004) were independent prognostic factors.
  • SMA reactivity is a predictor of benign clinical behavior in SISTs.
  • Tumor mitotic numbers, tumor size, and cell type were independent prognostic factors for patients with SISTs after operation.

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  • (PMID = 16607447.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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45. Yiğitler C, Ataç K, Yiğit T, Güleç B, Balkan M, Oner K: [A rare cause of bleeding intestinal intussusception in adult: jejunal lipoma]. Ulus Travma Acil Cerrahi Derg; 2007 Jul;13(3):237-40
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare cause of bleeding intestinal intussusception in adult: jejunal lipoma].
  • [Transliterated title] Erişkinde nadir bir intestinal intussusepsiyon ve kanama nedeni: Jejunal lipom.
  • Small bowel neoplasms are usually diagnosed when patients are referred with complications such as hemorrhage or obstruction.
  • Intestinal lipomas are the third most frequent benign tumors among all intestinal neoplasms and their definite diagnosis is usually obtained after histopathological examination of the resected specimen.
  • A 76 year-old male patient with partial intestinal obstruction and rectal bleeding at admittance was found to have an abdominal mass on ultrasound.
  • The diagnosis of lipoma was confirmed with histopathological examination of the mass removed by an elective intestinal resection.
  • This case was reported as the intestinal lipoma leading a jejunojejunal intussusception associated with bleeding, could be diagnosed preoperatively.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Intussusception / diagnosis. Intussusception / etiology. Jejunal Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 17978901.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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46. Niederle MB, Hackl M, Kaserer K, Niederle B: Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocr Relat Cancer; 2010 Dec;17(4):909-18
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  • [Title] Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters.
  • Using the current WHO classification, the tumor, nodes, metastases (TNM) staging and Ki67 grading and the standard diagnostic procedure proposed by the European Neuroendocrine Tumor Society (ENETS), GEP-NETs from 285 patients (male: 148; female: 137) were recorded.
  • The stomach (23%) was the main site, followed by appendix (21%), small intestine (15%) and rectum (14%).
  • About 46.0% were classified as benign, 15.4% as uncertain, 31.9% as well differentiated malignant and 6.7% as poorly differentiated malignant.
  • Patients with benign or uncertain tumours were significantly younger than patients with malignant tumours.
  • Among the malignant tumours of the digestive tract, 1.49% arose from neuroendocrine cells.
  • NETs of the digestive tract are more common than previously reported; the majority show benign behaviour, are located in the stomach and are well differentiated.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Neuroendocrine Tumors / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Age Factors. Austria / epidemiology. Female. Histocytochemistry. Humans. Incidence. Male. Middle Aged. Neoplasm Staging / methods. Prospective Studies

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  • (PMID = 20702725.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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47. Ba MC, Qing SH, Huang XC, Wen Y, Li GX, Yu J: Application of laparoscopy in diagnosis and treatment of massive small intestinal bleeding: report of 22 cases. World J Gastroenterol; 2006 Nov 21;12(43):7051-4
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  • [Title] Application of laparoscopy in diagnosis and treatment of massive small intestinal bleeding: report of 22 cases.
  • AIM: To investigate the diagnostic and therapeutic value of laparoscopy in patients with massive small intestinal bleeding.
  • METHODS: Twenty-two patients with massive small intestinal bleeding and hemodynamic alteration underwent laparoscopic laparotomy in our unit from December 2002 to April 2005.
  • Post pathologic sites were found, laparoscopy- or laparoscopy-assisted part small intestinal resection including pathologic intestinal site and enteroanastomosis was performed in all these patients.
  • Massive small intestinal bleeding was caused by jejunum benign stromal tumor in 8 cases, by jejunum potential malignant stromal tumor in 5 cases, by jejunum malignant stromal tumor in 1 case, by Mechel's diverticulum in 5 cases, by small intestinal vascular deformity in 2 cases, and by ectopic pancreas in 1 case.
  • A total of 16 patients underwent laparoscopy-assisted enterectomy and enteroanastomosis of small intestine covering the diseased segment and 6 patients received enterectomy of the diseased segment under laparoscope.
  • CONCLUSION: Laparoscopy in diagnosis and treatment of massive small intestinal bleeding is noninvasive with less pain, short recovery time and definite therapeutic efficacy.
  • [MeSH-major] Anastomosis, Surgical / methods. Gastrointestinal Hemorrhage / diagnosis. Gastrointestinal Hemorrhage / surgery. Intestinal Diseases / diagnosis. Intestinal Diseases / surgery. Intestine, Small / surgery. Laparoscopy / methods

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  • [Cites] J Pediatr Surg. 2000 Sep;35(9):1291-3 [10999681.001]
  • [Cites] J Gastroenterol Hepatol. 2005 May;20(5):716-21 [15853984.001]
  • [Cites] JSLS. 2002 Apr-Jun;6(2):179-80 [12113425.001]
  • [Cites] Endoscopy. 2002 Sep;34(9):685-9 [12195324.001]
  • [Cites] Gastrointest Endosc. 2002 Sep;56(3):349-53 [12196771.001]
  • [Cites] Pediatr Surg Int. 2003 Jun;19(4):266-7 [12721709.001]
  • [Cites] Abdom Imaging. 2003 Sep-Oct;28(5):634-6 [14628865.001]
  • [Cites] Arch Pathol Lab Med. 2004 Feb;128(2):214-7 [14736280.001]
  • [Cites] Endoscopy. 2004 May;36(5):416-20 [15100950.001]
  • [Cites] Surg Endosc. 2004 Mar;18(3):554-6 [15115012.001]
  • [Cites] J Gastroenterol. 2004;39(4):375-8 [15168250.001]
  • [Cites] Pediatr Surg Int. 2004 May;20(5):323-5 [15241619.001]
  • [Cites] Gastrointest Endosc. 2004 Aug;60(2):309-12 [15278071.001]
  • [Cites] Surg Endosc. 1998 Jul;12(7):995-6 [9632878.001]
  • [Cites] Radiology. 1999 Apr;211(1):197-201 [10189471.001]
  • [Cites] Endoscopy. 2005 Feb;37(2):122-32 [15692927.001]
  • [Cites] J Am Coll Surg. 2005 Apr;200(4):631 [15804479.001]
  • [Cites] Am J Gastroenterol. 2005 May;100(5):1058-64 [15842579.001]
  • [Cites] Gastrointest Endosc. 2005 Jun;61(7):826-32 [15933683.001]
  • [Cites] Surg Endosc. 2001 Nov;15(11):1359 [11727152.001]
  • (PMID = 17109505.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087354
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48. Koay MH, Goh YW, Iacopetta B, Grieu F, Segal A, Sterrett GF, Platten M, Spagnolo DV: Gastrointestinal stromal tumours (GISTs): a clinicopathological and molecular study of 66 cases. Pathology; 2005 Feb;37(1):22-31
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  • AIMS: Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established.
  • (1) appropriate morphology, (2) CD117 positivity, (3) adequacy of pathological material for study, and (4) exclusion of other tumour types on the basis of immunophenotypic and/or ultrastructural features.
  • Tumours were mostly located in the stomach (67%) and small intestine (SI; 25%).
  • c-kit mutations were found in 69% of GISTs, with the large majority (91%) occurring in exon 11.
  • Size > or = 10 cm, tumour necrosis and pure epithelioid cell morphology each were the only factors significantly associated with adverse survival (p=0.038, and p=0.047 and p=0.028, respectively).
  • c-kit mutations were more frequent in small intestinal GISTs (p=0.05) and in those with pure spindle cell morphology (p=0.023) but were not associated with patient outcome.
  • CD117 staining of any mesenchymal lesion of the gastrointestinal tract should be mandatory for accurate classification.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 15875730.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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49. Korsisaari N, Kasman IM, Forrest WF, Pal N, Bai W, Fuh G, Peale FV, Smits R, Ferrara N: Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice. Proc Natl Acad Sci U S A; 2007 Jun 19;104(25):10625-30
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  • Anti-VEGF-A monoclonal antibodies, in combination with chemotherapy, result in a survival benefit in patients with metastatic colorectal and non-small cell lung cancer, but little is known regarding the impact of anti-VEGF-A therapy on benign or premalignant tumors.
  • The Apc+/min mice have been widely used as a model recapitulating early intestinal adenoma formation.
  • To investigate whether tumor growth in Apc+/min mice is mediated by VEGF-A-dependent angiogenesis, we used two independent approaches to inhibit VEGF-A: monotherapy with a monoclonal antibody (Mab) targeting VEGF-A and genetic deletion of VEGF-A selectively in intestinal epithelial cells.
  • Short-term (3 or 6 weeks) treatment with anti-VEGF-A Mab G6-31 resulted in a nearly complete suppression of adenoma growth throughout the small intestine.
  • Deletion of VEGF-A in intestinal epithelial cells of Apc+/min mice yielded a significant inhibition of tumor growth, albeit of lesser magnitude than that resulting from Mab G6-31 administration.
  • These results establish that inhibition of VEGF-A signaling is sufficient for tumor growth cessation and confers a long-term survival benefit in an intestinal adenoma model.
  • Therefore, VEGF-A inhibition may be a previously uncharacterized strategy for the prevention of the angiogenic switch and growth in intestinal adenomas.
  • [MeSH-minor] Adenoma / blood supply. Adenoma / genetics. Adenoma / immunology. Adenoma / therapy. Animals. Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / pharmacology. Gene Deletion. In Situ Hybridization. Intestinal Neoplasms / blood supply. Intestinal Neoplasms / genetics. Intestinal Neoplasms / immunology. Intestinal Neoplasms / therapy. Mice. Mice, Inbred C57BL. Signal Transduction / immunology. Survival Analysis. Time Factors

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  • [Cites] Cancer Res. 1999 Oct 15;59(20):5209-18 [10537299.001]
  • [Cites] J Natl Cancer Inst. 2006 Mar 1;98(5):316-25 [16507828.001]
  • [Cites] Genes Dev. 2000 Aug 1;14(15):1837-51 [10921899.001]
  • [Cites] Cancer Res. 2000 Sep 15;60(18):5040-4 [11016626.001]
  • [Cites] Cancer Res. 2000 Nov 15;60(22):6253-8 [11103779.001]
  • [Cites] Cancer Lett. 2002 Jan 25;175(2):157-63 [11741743.001]
  • [Cites] Cancer Res. 2002 Jan 15;62(2):506-11 [11809702.001]
  • [Cites] Dev Dyn. 2002 May;224(1):90-102 [11984877.001]
  • [Cites] Carcinogenesis. 2002 Aug;23(8):1351-9 [12151354.001]
  • [Cites] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11393-8 [12177445.001]
  • [Cites] J Biol Chem. 2002 Sep 6;277(36):33275-83 [12065599.001]
  • [Cites] Expert Opin Investig Drugs. 2002 Dec;11(12):1715-36 [12457433.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):391-400 [12750232.001]
  • [Cites] Br J Cancer. 2003 May 6;88(9):1445-52 [12778076.001]
  • [Cites] Nat Med. 2003 Jun;9(6):669-76 [12778165.001]
  • [Cites] Curr Biol. 2003 Sep 30;13(19):1721-7 [14521839.001]
  • [Cites] N Engl J Med. 2004 Jun 3;350(23):2335-42 [15175435.001]
  • [Cites] Endocr Rev. 2004 Aug;25(4):581-611 [15294883.001]
  • [Cites] J Exp Med. 1972 Aug 1;136(2):261-76 [5043412.001]
  • [Cites] Proc Natl Acad Sci U S A. 1985 Dec;82(24):8488-92 [3909146.001]
  • [Cites] Science. 1990 Jan 19;247(4940):322-4 [2296722.001]
  • [Cites] Science. 1992 May 1;256(5057):668-70 [1350108.001]
  • [Cites] Development. 1992 Jul;115(3):717-28 [1425351.001]
  • [Cites] Nature. 1993 Apr 29;362(6423):841-4 [7683111.001]
  • [Cites] J Clin Invest. 1995 Apr;95(4):1789-97 [7535799.001]
  • [Cites] Nat Med. 1995 Jan;1(1):27-31 [7584949.001]
  • [Cites] Cancer Res. 1996 Jun 1;56(11):2556-60 [8653697.001]
  • [Cites] Cell. 1996 Aug 9;86(3):353-64 [8756718.001]
  • [Cites] Cell. 1996 Nov 29;87(5):803-9 [8945508.001]
  • [Cites] Nature. 1997 Apr 17;386(6626):671-4 [9109485.001]
  • [Cites] Cancer Res. 1997 Oct 1;57(19):4267-73 [9331087.001]
  • [Cites] Prostate. 1998 Apr 1;35(1):1-10 [9537593.001]
  • [Cites] Carcinogenesis. 1999 Jan;20(1):51-8 [9934849.001]
  • [Cites] Development. 1999 Mar;126(6):1149-59 [10021335.001]
  • [Cites] Science. 2005 Jan 7;307(5706):58-62 [15637262.001]
  • [Cites] Cancer Res. 2005 May 15;65(10):4389-400 [15899831.001]
  • [Cites] Nature. 2005 Dec 15;438(7070):967-74 [16355214.001]
  • [Cites] J Biol Chem. 2006 Jan 13;281(2):951-61 [16278208.001]
  • [Cites] Exp Cell Res. 2006 Mar 10;312(5):549-60 [16336962.001]
  • [Cites] Br J Cancer. 2006 Jun 5;94(11):1710-7 [16685275.001]
  • [Cites] Carcinogenesis. 2006 Oct;27(10):2133-9 [16782971.001]
  • [Cites] N Engl J Med. 2006 Dec 14;355(24):2542-50 [17167137.001]
  • [Cites] N Engl J Med. 2007 Jan 11;356(2):115-24 [17215529.001]
  • [Cites] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3478-83 [17360669.001]
  • [Cites] J Clin Invest. 2000 Jun;105(11):1589-94 [10841517.001]
  • (PMID = 17553957.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Vascular Endothelial Growth Factor A
  • [Other-IDs] NLM/ PMC1888576
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50. Engelman RW, Jackson RJ, Coppola D, Wharton W, Cantor AB, Pledger WJ: Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice. Exp Mol Pathol; 2007 Jun;82(3):234-44
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  • Although gamma-irradiated p21(+/-) mice develop a broad spectrum of tumors, gamma-irradiated p21(-/-) mice develop significantly more metastatic cancers.
  • To evaluate the expression of p21 in tissues prone or resistant to tumorigenesis as a function of gamma-irradiation, and to determine whether phenotypic loss of p21 heterozygosity occurs during tumor progression in p21(+/-) mice, tissues and tumors from gamma-irradiated mice were evaluated immunohistochemically.
  • The percentage of tumors in p21(+/-) mice that were nuclear p21-positive declined with progression to metastasis (p<0.0001).
  • Benign tumors were more often p21-positive and comprised of larger subsets of nuclear p21-positive cells than were malignant tumors of the same histopathological type, while metastatic cancers were nuclear p21-negative (p=0.0003).
  • Mesenchymal tumors, though rare, were more likely metastatic than were epithelial tumors (p=0.0004), and these were invariably nuclear p21-negative.
  • Prepubescent epithelial tissues from which most tumors later originated in mice with reduced p21 gene dosage (i.e., harderian gland, ovary, small intestine, and lung) were p21 expressive within 4 h of gamma-irradiation (p=0.0625), so that p21/Ki67 ratios increased post-gamma-irradiation (p=0.03).
  • Cellular subclones of malignant tumors, especially those of mesenchymal cell origin, which lack nuclear p21 may more readily acquire the genetic alterations of the metastatic phenotype.

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  • [Cites] Genes Dev. 1997 Apr 1;11(7):847-62 [9106657.001]
  • [Cites] Oncogene. 1999 Aug 19;18(33):4689-98 [10467416.001]
  • [Cites] Int J Cancer. 2000 Jan 20;89(1):14-8 [10719725.001]
  • [Cites] Adv Exp Med Biol. 1999;472:73-88 [10736618.001]
  • [Cites] Clin Cancer Res. 2000 Mar;6(3):1113-8 [10741741.001]
  • [Cites] Mol Cell Biol. 2000 Aug;20(16):6147-58 [10913196.001]
  • [Cites] Biochim Biophys Acta. 2000 Jul 31;1471(1):M43-56 [10967424.001]
  • [Cites] Oncogene. 2000 Nov 9;19(47):5338-47 [11103935.001]
  • [Cites] Cancer Res. 2001 Jan 15;61(2):565-9 [11212250.001]
  • [Cites] EMBO Rep. 2001 Jan;2(1):27-34 [11252720.001]
  • [Cites] Nat Cell Biol. 2001 Mar;3(3):245-52 [11231573.001]
  • [Cites] Cancer Res. 2001 Aug 15;61(16):6234-8 [11507077.001]
  • [Cites] Virchows Arch. 2001 Aug;439(2):132-40 [11561753.001]
  • [Cites] Blood. 2002 Apr 1;99(7):2291-6 [11895758.001]
  • [Cites] Cancer Res. 2002 Apr 1;62(7):2077-84 [11929828.001]
  • [Cites] Semin Cancer Biol. 2002 Apr;12(2):89-96 [12027580.001]
  • [Cites] Nat Rev Cancer. 2002 Aug;2(8):563-72 [12154349.001]
  • [Cites] Oncogene. 2002 Dec 5;21(55):8486-97 [12466968.001]
  • [Cites] Nat Genet. 2003 Jan;33(1):49-54 [12469122.001]
  • [Cites] Cancer Res. 2003 Jun 15;63(12):3021-5 [12810620.001]
  • [Cites] Oncogene. 2004 Aug 5;23(35):6006-11 [15195145.001]
  • [Cites] Science. 1977 Aug 26;197(4306):893-5 [887927.001]
  • [Cites] Science. 1987 Jan 9;235(4785):177-82 [3798106.001]
  • [Cites] Nature. 1993 Apr 29;362(6423):847-9 [8479522.001]
  • [Cites] Nature. 1993 Apr 29;362(6423):849-52 [8479523.001]
  • [Cites] Cell. 1993 Nov 19;75(4):805-16 [8242751.001]
  • [Cites] Cell. 1993 Nov 19;75(4):817-25 [8242752.001]
  • [Cites] Nature. 1993 Dec 16;366(6456):701-4 [8259214.001]
  • [Cites] Mol Cell Biol. 1994 Mar;14(3):1815-23 [8114714.001]
  • [Cites] Radiother Oncol. 1994 Apr;31(1):1-13 [8041894.001]
  • [Cites] Oncogene. 1994 Nov;9(11):3389-96 [7936667.001]
  • [Cites] Oncogene. 1994 Nov;9(11):3397-406 [7936668.001]
  • [Cites] Blood. 1994 Dec 1;84(11):3781-4 [7949134.001]
  • [Cites] Science. 1994 Dec 16;266(5192):1821-8 [7997877.001]
  • [Cites] Science. 1995 Feb 17;267(5200):1018-21 [7863327.001]
  • [Cites] Science. 1995 Feb 17;267(5200):1024-7 [7863329.001]
  • [Cites] Nature. 1995 Mar 9;374(6518):131-4 [7877684.001]
  • [Cites] Oncogene. 1995 Jun 15;10(12):2281-7 [7784076.001]
  • [Cites] Cancer Res. 1995 Jul 1;55(13):2910-9 [7796420.001]
  • [Cites] Cell. 1995 Aug 25;82(4):675-84 [7664346.001]
  • [Cites] Biochim Biophys Acta. 1995 Sep 19;1263(3):275-80 [7548219.001]
  • [Cites] Nature. 1995 Oct 12;377(6549):552-7 [7566157.001]
  • [Cites] Cancer Res. 1995 Nov 15;55(22):5187-90 [7585571.001]
  • [Cites] J Cell Biol. 1996 Feb;132(4):657-66 [8647896.001]
  • [Cites] Am J Pathol. 1996 Aug;149(2):381-7 [8701978.001]
  • [Cites] Biochem J. 1995 Jun 15;308 ( Pt 3):697-711 [8948422.001]
  • [Cites] Curr Opin Genet Dev. 1997 Feb;7(1):46-51 [9024633.001]
  • [Cites] Leuk Lymphoma. 1997 Jun;26(1-2):35-41 [9250785.001]
  • [Cites] Int J Cancer. 1997 Oct 21;74(5):529-34 [9355976.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14590-5 [9405657.001]
  • [Cites] J Cell Biol. 1998 Apr 20;141(2):503-14 [9548727.001]
  • [Cites] Clin Cancer Res. 1998 May;4(5):1251-61 [9607584.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6791-6 [9618491.001]
  • [Cites] Mol Cell. 1998 Mar;1(4):553-63 [9660939.001]
  • [Cites] Genes Dev. 1999 Jan 15;13(2):213-24 [9925645.001]
  • [Cites] EMBO J. 1999 Mar 1;18(5):1223-34 [10064589.001]
  • [Cites] Cancer Res. 1999 May 1;59(9):2050-4 [10232585.001]
  • [Cites] Blood. 1999 Jun 15;93(12):4167-78 [10361114.001]
  • [Cites] Genes Dev. 1999 Jun 15;13(12):1501-12 [10385618.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9089-94 [10430900.001]
  • [Cites] Cancer Res. 2000 Jan 15;60(2):262-5 [10667572.001]
  • (PMID = 17207793.001).
  • [ISSN] 0014-4800
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA67360; United States / NCI NIH HHS / CA / P01 CA078038-040004; United States / NCI NIH HHS / CA / CA078038-040004; United States / NCI NIH HHS / CA / CA067360-09; United States / NCI NIH HHS / CA / R01 CA067360-09; United States / NCI NIH HHS / CA / R01 CA067360; United States / NCI NIH HHS / CA / CA78038
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen
  • [Other-IDs] NLM/ NIHMS24071; NLM/ PMC2039892
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51. Van Weyenberg SJ, Meijerink MR, Jacobs MA, Van der Peet DL, Van Kuijk C, Mulder CJ, Van Waesberghe JH: MR enteroclysis in the diagnosis of small-bowel neoplasms. Radiology; 2010 Mar;254(3):765-73
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  • [Title] MR enteroclysis in the diagnosis of small-bowel neoplasms.
  • PURPOSE: To evaluate the diagnostic accuracy and interobserver variance of magnetic resonance (MR) enteroclysis in the diagnosis of small-bowel neoplasms, with small-bowel endoscopy, surgery, histopathologic analysis, and follow-up serving as standards of reference, and to identify MR enteroclysis characteristics capable of enabling discrimination between benign and malignant small-bowel neoplasms.
  • Only studies explicitly performed to investigate or exclude the presence of small-bowel neoplasms were included.
  • Tumor characteristics were compared with the Student t test and the Fisher exact test.
  • RESULTS: Readers 1 and 2 interpreted 31 and 33 studies, respectively, as depicting a small-bowel neoplasm and 19 and 17 studies, respectively, as depicting small-bowel malignancy.
  • In 32 patients, the presence of small-bowel neoplasm was confirmed.
  • In 19 of these patients, the neoplasm was malignant.
  • Sensitivity and specificity in the diagnosis of small-bowel neoplasms was 0.91 and 0.95, respectively, for reader 1 and 0.94 and 0.97, respectively, for reader 2; the kappa value was 0.95.
  • CONCLUSION: Eighty-six of 91 studies were correctly interpreted, resulting in an overall diagnostic accuracy of 0.95 for MR enteroclysis in the detection of small-bowel neoplasms.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small. Magnetic Resonance Imaging / methods

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  • [Copyright] (c) RSNA, 2010
  • (PMID = 20177091.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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52. Bailey AA, Debinski HS, Appleyard MN, Remedios ML, Hooper JE, Walsh AJ, Selby WS: Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience. Am J Gastroenterol; 2006 Oct;101(10):2237-43

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  • [Title] Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience.
  • OBJECTIVE: The objective of the study was to examine diagnosis and outcome in a series of patients with small bowel tumors detected by capsule endoscopy (CE) in three Australian centers.
  • METHODS: Review of prospectively collected data from 416 CEs identified 27 tumors in 26 patients.
  • Clinical parameters, tumor histology, and follow-up are reported.
  • RESULTS: Twenty-seven tumors were identified in 26 patients (mean age 61 +/- 13.7 yr).
  • Indications for CE were obscure gastrointestinal (GI) bleeding (21), suspected tumor (3), abdominal pain (1), diarrhea (1).
  • Nine tumors were proven benign: hamartoma (4), cystic lymphangioma (1), primary amyloid (1), lipoma (1).
  • Seventeen tumors were malignant: five adenocarcinomas, six carcinoids, two melanoma metastases, two gastrointestinal stromal tumors (GIST), one colon carcinoma metastasis, one non-Hodgkin's lymphoma.
  • Tumors were surgically resected in 23 patients.
  • Three of the six with carcinoid tumors have had no recurrence up to 51 months postresection.
  • CONCLUSIONS: Small bowel tumors are a significant finding at CE and are often missed by other methods of investigation.
  • In many patients, detection of a tumor alters management and improves outcome.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / pathology. Intestinal Neoplasms / therapy. Intestine, Small

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  • (PMID = 17032187.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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53. Konstantinidis K, Theodoropoulos GE, Spanomihos G, Sambalis G, Vorias M, Georgiou M, Anastassakou K: Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding. J Laparoendosc Adv Surg Tech A; 2005 Aug;15(4):396-9
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  • [Title] Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding.
  • A 2.5 cm diameter, smooth, hypervascular tumor was easily visualized on the jejunal wall 10 cm from the ligament of Treitz.
  • The small bowel segment was laparoscopically mobilized and brought through the subumbilical trocar site, which was extended 1 cm.
  • A limited small bowel resection and a stapled anastomosis were easily performed extracorporeally.
  • Histopathologic examination diagnosed a benign gastrointestinal tumor (gastrointestinal stromal tumor, leiomyoma).
  • Laparoscopic identification and mobilization allows a loop of small bowel to be exteriorized through a small incision; the anastomosis can be safely performed extracorporeally.
  • [MeSH-major] Endoscopy, Gastrointestinal. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Hemorrhage / surgery. Intestinal Neoplasms / complications. Intestinal Neoplasms / surgery. Leiomyoma / complications. Leiomyoma / surgery
  • [MeSH-minor] Anastomosis, Surgical. Humans. Intestine, Small. Male. Middle Aged

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  • (PMID = 16108744.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Bayle S, Rossi P, Bagneres D, Demoux AL, Ashero A, Dales JP, Vitton V, Frances Y, Granel B: [Ileum inflammatory fibroid polyp revealed by intussusception. About one familial case]. Rev Med Interne; 2005 Mar;26(3):233-7
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  • INTRODUCTION: Acute ileum intussusception is a frequent and mostly benign condition in childhood.
  • We report a familial form of benign inflammatory fibroid polyps, revealed by an acute ileum intussusception.
  • The patient displayed alteration of the intestinal transit, weight loss and sub-occlusive syndrome.
  • In the emergency room, the abdominal computed tomography-scan revealed an acute intussusception of the last loop of the small intestine, probably caused by a tumor and leading to an occlusive syndrome.
  • CONCLUSION: Inflammatory fibroid polyp is always a benign tumor.
  • It is usually isolated, expressing itself mainly in the form of an acute intussusception when located in the small bowel.

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  • (PMID = 15777585.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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55. Baichi MM, Arifuddin RM, Mantry PS: Small-bowel masses found and missed on capsule endoscopy for obscure bleeding. Scand J Gastroenterol; 2007 Sep;42(9):1127-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small-bowel masses found and missed on capsule endoscopy for obscure bleeding.
  • OBJECTIVE: Data on the nature of small-bowel tumors found or missed by capsule endoscopy (CE) are limited.
  • The aim of this study was to review the CE findings in patients with small-bowel tumors presenting as obscure gastrointestinal (GI) bleeding.
  • RESULTS: Ten (3%) confirmed small-bowel masses were found in 9 patients.
  • Most (80%) of the lesions were potentially malignant: adenocarcinoma (n=4), neuroendocrine carcinoma (n=1), leiomyosarcoma (n=1), and GI stroma cell tumors (GISTs) (n=2).
  • Benign lesions included inflammatory fibroid polyp (n=1) and lipoma (n=1).
  • CE findings led directly to tumor diagnosis in 7 of the 10 cases.
  • CONCLUSIONS: Small-bowel tumors are a rare but serious source of obscure GI bleeding.
  • Our large single-center experience shows that most lesions are of malignant potential.
  • Tumors can have an atypical appearance including focal ulceration, nodularity, or active bleeding without a clear lesion.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Gastrointestinal Hemorrhage / etiology. Humans. Intestine, Small. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17710681.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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56. Pulitzer M, Xu R, Suriawinata AA, Waye JD, Harpaz N: Microcarcinoids in large intestinal adenomas. Am J Surg Pathol; 2006 Dec;30(12):1531-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcarcinoids in large intestinal adenomas.
  • Composite adenoma-carcinoid tumors are rare colorectal lesions consisting of intermingled adenomatous and carcinoid components.
  • Unlike other mixed endocrine-glandular colorectal neoplasms, which are generally malignant, their glandular component is histologically benign and their natural history is favorable.
  • The patients' clinical course was benign on the basis of 2 years' median follow-up (range, 6 mo to 10 y).
  • Two patients with incomplete polypectomies underwent hemicolectomy revealing no residual endocrine neoplasia.
  • Awareness of microcarcinoids in colonic adenomas should help avert potential diagnostic pitfalls posed by their pleomorphism, basal location, and infiltrative patterns, and may help clarify their natural history and possible relationship to composite glandular-carcinoid tumors.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Intestinal Neoplasms / pathology. Intestine, Large / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Female. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 17122508.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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57. Schurink M, van Herwaarden-Lindeboom MY, Coppes MH, Veldhuizen AG, Koetse HA, de Langen ZJ: Neurenteric cyst--a case report of this rare disorder. J Pediatr Surg; 2007 May;42(5):E5-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurenteric cyst--a case report of this rare disorder.
  • We report the clinical case of a 5-year-old boy presenting with vague gastrointestinal symptoms and fatigue, who had undergone resection of a small intestine duplication cyst as a newborn.
  • Resection of the tumor proved effective.
  • Recognition of this disorder is important: because of its benign nature, the prognosis after surgical resection can be good.

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  • (PMID = 17502175.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Coste I, Freund JN, Spaderna S, Brabletz T, Renno T: Precancerous lesions upon sporadic activation of beta-catenin in mice. Gastroenterology; 2007 Apr;132(4):1299-308
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  • BACKGROUND & AIMS: Inappropriate activation of beta-catenin in adult tissues is associated with a wide variety of cancers, especially in the digestive tract.
  • Classic transgenic and knockout murine models in which beta-catenin is activated in large fields of cells have provided experimental support in favor of a role for this molecule in tumorigenesis.
  • No lesion was detected in the intestine or in the liver.
  • In addition, one third of female mutant mice developed benign perimammary papillomas.
  • CONCLUSIONS: These results challenge the view that activation of beta-catenin induces malignant cancerogenesis, because they show in mice that sporadically activated beta-catenin is sufficient for tumor initiation, yet without further malignant progression, and that it sensitizes cells to environmental hits.
  • This model represents a powerful tool to investigate the interplay between genetic and environmental factors in tumor progression.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Precancerous Conditions / pathology. RNA, Neoplasm / genetics. Skin Neoplasms / pathology. Stomach Neoplasms / pathology. beta Catenin / genetics
  • [MeSH-minor] Animals. Cell Line, Tumor. Disease Progression. Female. Immunohistochemistry. Mice. Mice, Inbred C57BL. Mice, Knockout. Neoplasms, Experimental. Phenotype. Polymerase Chain Reaction. Pregnancy

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  • (PMID = 17408631.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 0 / beta Catenin
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59. Lasota J, Wang ZF, Sobin LH, Miettinen M: Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases. Mod Pathol; 2009 Aug;22(8):1049-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases.
  • The inflammatory fibroid polyp is a rare benign lesion occurring throughout the digestive tract.
  • In this study, PDGFRA exons 12, 14, and 18 were screened for activating mutations in 60 small intestinal inflammatory fibroid polyps.
  • However, 1835_1852delinsCGC leading to the same S566_E571delinsR, were found in two tumors.
  • Similar gain-of-function PDGFRA mutations reported in gastrointestinal stromal tumors have been considered to be a driving pathogenetic force.
  • This study showed consistent expression and common mutational activation of PDGFRA in small intestinal inflammatory fibroid polyps as in their gastric counterparts, and these lesions should be considered PDGFRA-driven benign neoplasms.
  • [MeSH-major] Biomarkers, Tumor / genetics. Intestinal Neoplasms / genetics. Intestinal Polyps / genetics. Leiomyoma / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. Female. Gastrointestinal Stromal Tumors / genetics. Humans. Immunohistochemistry. Intestine, Small / pathology. Male. Middle Aged. Mutation. Polymerase Chain Reaction. Young Adult

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  • (PMID = 19448595.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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60. Sou S, Nomura H, Takaki Y, Nagahama T, Matsubara F, Matsui T, Yao T: Hemorrhagic duodenal lipoma managed by endoscopic resection. J Gastroenterol Hepatol; 2006 Feb;21(2):479-81
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An upper gastrointestinal roentgenologic study revealed a submucosal tumor with a smooth surface and a stalk measuring 50 mm at the third part of the duodenum.
  • Endoscopy depicted it as a yellowish submucosal tumor.
  • Based on computed tomography and fluoroscopy of the small intestine, a diagnosis of duodenal lipoma was made.
  • The esophagus, stomach, and the small and large intestines were free of lesions so the duodenal lipoma was judged to be the hemorrhagic source.
  • The tumor was endoscopically polypectomized using a 2-channel scope.
  • The excised specimen, measuring 50 x 20 x 20 mm, was covered by a normal duodenal mucosa with small ulcers in part.
  • Photomicrographic findings included a tumor that was composed of mature adipose tissue in the submucosa, which coincided with a diagnosis of lipoma.
  • Small ulcers had formed in part, exposing vessels, thus indicating the cause for hemorrhage.
  • Lipoma is a benign tumor; and if the lesion is found to be pedunculated and an endoscope can reach it for treatment, minimally invasive endoscopic procedures should be selected.
  • [MeSH-major] Duodenal Neoplasms / complications. Electrocoagulation / methods. Endoscopy, Gastrointestinal. Gastrointestinal Hemorrhage / surgery. Lipoma / complications

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  • (PMID = 16509883.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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61. Pratap A, Tiwari A, Pandey S, Yadav RP, Agrawal A, Sah BP, Bajracharya T, Ghimere A: Ganglioneuroma of small bowel mesentery presenting as acute abdomen. J Pediatr Surg; 2007 Mar;42(3):573-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ganglioneuroma of small bowel mesentery presenting as acute abdomen.
  • Ganglioneuroma is a rare benign tumor, usually seen in children and young adults, arising in the central nervous system.
  • [MeSH-major] Abdomen, Acute / etiology. Ganglioneuroma / complications. Intestine, Small. Mesentery. Peritoneal Neoplasms / complications

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  • (PMID = 17336204.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Kan H, Suzuki H, Shinji S, Naito Z, Furukawa K, Tajiri T: Case of an inflammatory fibroid polyp of the cecum. J Nippon Med Sch; 2008 Jun;75(3):181-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An inflammatory fibroid polyp (IFP) is a rare benign lesion, originating in the submucosa of the gastrointestinal tract.
  • It typically arises in the stomach and small intestine but also arises infrequently in the colon.
  • The lesion was diagnosed to be a submucosal tumor.
  • Immunohistochemical staining of the spindle-shaped cells, which were present around the small vessels in the stroma of the tumor, showed that the tissue expressed vimentin but not alpha-smooth muscle actin, desmin, S-100, c-kit or CD 34.
  • [MeSH-major] Cecal Neoplasms / surgery. Intestinal Polyps / surgery

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  • (PMID = 18648178.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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63. Drasković M, Misović S, Kronja G, Krsić J, Tomić A, Sarac M: [Jejuno-jejunal intussusception in adults secondary to submucosal leiomyoma]. Med Pregl; 2005 Jul-Aug;58(7-8):405-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Intussusception is the invagionation of a segment of the intestine into itself.
  • Intussusception in adults is usually caused by tumors, benign or malignant.
  • Intussusception of the small bowel was diagnosed by CT examination.
  • Laparotomy revealed a jejunojejunal intussusception caused by a small bowel tumor.
  • CONCLUSION: The tumor in the jejunum, almost completely obstructed the intestinal lumen and it was resected and bowel continuity was restored.
  • [MeSH-major] Ileal Diseases / etiology. Intussusception / etiology. Jejunal Neoplasms / complications. Leiomyoma / complications

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  • (PMID = 16296586.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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64. Schöniger S, Summers BA: Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken. Vet Pathol; 2009 Sep;46(5):904-15

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors.
  • In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established.
  • We describe peripheral nerve sheath tumors with microscopic, immunohistologic, and ultrastructural features similar to those in subtypes of human neurofibroma in 12 dogs, 2 horses, and 1 chicken.
  • The canine tumors were located in the skin, peripheral nerve, tongue, and large intestine.
  • The equine tumors were located in the subcutis of the neck and axilla.
  • The chicken was a mature white Leghorn chicken with an ocular neoplasm.
  • Two plexiform neurofibromas occurred together with diffuse ganglioneuromatosis in the large intestine of young dogs, as has also been reported in humans.
  • This investigation shows the existence of identical subtypes of neurofibroma in animals and humans and identifies similarities in tumor location and patient age between animals and humans.
  • This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.

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  • (PMID = 19429995.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Miettinen M, Kraszewska E, Sobin LH, Lasota J: A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia. Cancer; 2008 Feb 1;112(3):645-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia.
  • BACKGROUND: Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling.
  • These tumors most commonly occur in the stomach and small intestine and encompass a clinical spectrum from benign to malignant.
  • BACKGROUND: Nine patients (2 with gastric GISTs and 7 with GISTs of the small intestine) developed myeloid leukemia.
  • All but 1 GIST case was found to have a low mitotic rate (0-1 per 50 high-power fields); however, tumor size varied from 3 to 18 cm (median, 4.5 cm).
  • [MeSH-major] Gastrointestinal Stromal Tumors / epidemiology. Intestinal Neoplasms / epidemiology. Leukemia, Myeloid / epidemiology. Stomach Neoplasms / epidemiology


66. Bakker JR, Haber MM, Garcia FU: Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction. Am Surg; 2005 Feb;71(2):100-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • NF-1 is known to be associated with gastrointestinal neoplasms in 2-25 per cent of patients.
  • The literature is reviewed, examining 61 previously reported cases of noncarcinoid gastrointestinal (GI) neoplasms in patients with NF-1 for symptoms, location, and types of neoplasms.
  • Neoplasms were located most often in the small intestine (72%).
  • Neurofibromas, found in 52 per cent of patients, were the most frequently diagnosed benign neoplasms followed by leiomyomas (13%), ganglioneurofibromas (9.8%), and gastrointestinal stomal tumor (GIST) (6.5%).
  • Patients with NF-1 and GI symptoms are at risk for gastrointestinal neoplasms from which symptomatic patients are likely to experience significant morbidity.
  • [MeSH-major] Gastric Outlet Obstruction / etiology. Neurofibromatosis 1 / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Duodenal Neoplasms / complications. Duodenal Neoplasms / pathology. Granulation Tissue / pathology. Humans. Male. Peptic Ulcer Perforation / etiology. Peptic Ulcer Perforation / pathology

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  • (PMID = 16022006.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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67. Sulentić P, Abdović S, Filipović J, Tomas D: Pedunculated myolipoma incidentally found in hernial sac: a case report. Acta Clin Croat; 2009 Jun;48(2):171-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of a very rare adipocytic tumor found during corrective surgery for incisional abdominal hernia is presented.
  • During surgery of incisional hernia, a part of small intestine along with a pedunculated tumor was found in hernial sac.
  • The tumor was attached to the medial intra-abdominal peritoneum.
  • On examination, the tumor presented as a totally encapsulated dimorphic benign neoplasm composed of mature adipocytes and well-differentiated smooth muscle cells.
  • Tumor cells were negative for HMB45, estrogen and progesterone.
  • This tumor commonly presents as a large quiescent mass in retroperitoneum in adult females and to our knowledge this is the first report of myolipoma in hernial sac.
  • Characteristic findings, differential diagnosis, prognosis and the possible origin of such a neoplasm are discussed.
  • [MeSH-major] Hernia, Abdominal / surgery. Lipoma / diagnosis. Peritoneal Neoplasms / diagnosis

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  • (PMID = 19928417.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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