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1. Kume K, Murata I, Yoshikawa I, Yamasaki M, Kanda K, Otsuki M: Endoscopic piecemeal mucosal resection of large colorectal tumors. Hepatogastroenterology; 2005 Mar-Apr;52(62):429-32
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  • [Title] Endoscopic piecemeal mucosal resection of large colorectal tumors.
  • BACKGROUND/AIMS: Since endoscopic en bloc resection of large and sessile tumors is technically difficult, endoscopic en bloc piecemeal mucosal resection (EPMR) is usually chosen for resection of such tumors.
  • Tumors resected by EPMR are, however, difficult to evaluate histologically.
  • METHODOLOGY: We removed 30 large colorectal tumors in 30 patients by EPMR between 1992-2000.
  • Patients in whom no residual tumor was found by both endoscopic and histologic examination were considered to be "cured".
  • RESULTS: Histological examination of the resected tumor tissues revealed malignancy in 43.3% (13/30).
  • Three patients had invasive malignant tumors and underwent surgery.
  • Following complete endoscopic resection, recurrences were observed in 2 patients with benign tumors, which were resected by additional endoscopic resection.
  • All patients including the two with non-invasive malignant tumors remain free from recurrence during a mean follow-up period of 45.2 months (range, 3-104 months).
  • CONCLUSIONS: EPMR of benign or non-invasive large malignant tumors is a safe and effective procedure.
  • Complete excision of large, sessile and non-invasive tumors is possible, although complete removal by EPMR cannot be verified histologically.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Colorectal Neoplasms / surgery. Endoscopy, Digestive System / methods. Intestinal Mucosa / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonoscopy. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 15816450.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Greece
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2. Mathew M, Gowri V, Al Hamdani A, Machado L, Rao K, Shabnam S: Cotyledonoid leiomyoma in pregnancy. Obstet Gynecol; 2007 Feb;109(2 Pt2):509-11
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  • BACKGROUND: Benign smooth-muscle tumors (leiomyomata) are the most frequent tumors found in the female genital tract.
  • CONCLUSION: Familiarity with benign uterine smooth-muscle tumors with unusual growth patterns by gynecologists and pathologists is essential in avoiding over-treatment.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Leiomyoma / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Prenatal Diagnosis. Smooth Muscle Tumor / diagnosis

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  • (PMID = 17267876.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Yiğitler C, Ataç K, Yiğit T, Güleç B, Balkan M, Oner K: [A rare cause of bleeding intestinal intussusception in adult: jejunal lipoma]. Ulus Travma Acil Cerrahi Derg; 2007 Jul;13(3):237-40
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  • [Title] [A rare cause of bleeding intestinal intussusception in adult: jejunal lipoma].
  • [Transliterated title] Erişkinde nadir bir intestinal intussusepsiyon ve kanama nedeni: Jejunal lipom.
  • Small bowel neoplasms are usually diagnosed when patients are referred with complications such as hemorrhage or obstruction.
  • Intestinal lipomas are the third most frequent benign tumors among all intestinal neoplasms and their definite diagnosis is usually obtained after histopathological examination of the resected specimen.
  • A 76 year-old male patient with partial intestinal obstruction and rectal bleeding at admittance was found to have an abdominal mass on ultrasound.
  • The diagnosis of lipoma was confirmed with histopathological examination of the mass removed by an elective intestinal resection.
  • This case was reported as the intestinal lipoma leading a jejunojejunal intussusception associated with bleeding, could be diagnosed preoperatively.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Intussusception / diagnosis. Intussusception / etiology. Jejunal Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 17978901.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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4. Sunada K, Yamamoto H: Technology and indications. Gastrointest Endosc Clin N Am; 2009 Jul;19(3):325-33
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  • Double-balloon endoscopy (DBE) was developed based on the principle of preventing stretching of the intestinal tract by anchoring the convoluted intestinal tract with an endoscope and overtube fitted with inflatable balloons.
  • The indications for DBE include the diagnosis or treatment of various small intestinal conditions such as obscure gastrointestinal bleeding, Crohn's disease, and benign and malignant tumors.
  • In addition, DBE can be used to approach the surgically modified intestinal tract; conventional endoscopes have difficulty in that situation.
  • [MeSH-major] Capsule Endoscopy. Duodenal Diseases / diagnosis. Gastrointestinal Hemorrhage / diagnosis. Ileal Diseases / diagnosis. Intestine, Small. Jejunal Diseases / diagnosis

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  • (PMID = 19647642.001).
  • [ISSN] 1558-1950
  • [Journal-full-title] Gastrointestinal endoscopy clinics of North America
  • [ISO-abbreviation] Gastrointest. Endosc. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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5. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • [Title] Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review.
  • Gastrointestinal stromal tumors (GIST) are rare in the vermiform appendix.
  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • Both gastrointestinal stromal tumors were incidental findings at surgery for appendicitis-like symptoms and on follow-up for bladder carcinoma, respectively.
  • Tumors were 5 and 25 mm and were located in the mid portion and the tip, respectively.
  • The larger gastrointestinal stromal tumor was pedunculated.
  • We suggest that the molecular pathogenesis of appendiceal gastrointestinal stromal tumors beyond initiating KIT mutations might be different from their gastric and intestinal counterparts.
  • The coincidence of loss of p16 and overexpression of human telomerase reverse transcriptase seems to be in contradiction to the small size, the benign nature, and the limited growth potential of appendiceal gastrointestinal stromal tumors.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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6. Serra S, Asa SL, Bamberger AM, Wagener C, Chetty R: CEACAM1 expression in pancreatic endocrine tumors. Appl Immunohistochem Mol Morphol; 2009 Jul;17(4):286-93
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  • [Title] CEACAM1 expression in pancreatic endocrine tumors.
  • The aim of this study was to examine the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in pancreatic endocrine tumors (PETs) and to correlate it with clinicopathologic parameters.
  • Sixty-nine PETs were examined for tumor size, necrosis, local peripancreatic invasion and lymphovascular invasion, lymph node, and liver metastasis.
  • The mitotic count, expressed per 10 high-power fields (HPF) and MIB1 index were assessed and tumors were classified according to the World Health Organization classification.
  • Twenty-nine tumors were from males and 40 from females, age range: 23 to 80 years (mean 52.4 y), tumor size ranged from 0.8 to 11 cm (mean 3.5 cm), 8 patients had multiple endocrine neoplasia 1 syndrome, and 1 had von Hippel-Lindau disease.
  • Twenty tumors demonstrated local invasion, 32 had lymphovascular invasion, 16 had lymph node metastasis, and 10 had liver metastasis.
  • In addition, 80% of tumors >or=2 cm in diameter were CEACAM positive (P<0.05).
  • CEACAM1-positive tumors were more frequently insulin negative (9 of 10 cases) (P=0.005) and vasoactive intestinal peptide-positive PETs were all CEACAM1 immunopositive (7 of 7 cases) (P=0.005).
  • Benign tumors and PETs of uncertain malignant behavior were more frequently CEACAM1-negative and low-grade malignant cases were CEACAM1 positive (27 of 29 cases) (P=0.001).
  • In addition, CEACAM1-positive tumors were statistically correlated with cytokeratin 19-positive tumors (P<0.05).

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  • (PMID = 19349857.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD66 antigens; 0 / Cell Adhesion Molecules; 0 / Neoplasm Proteins
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7. Lasota J, vel Dobosz AJ, Wasag B, Wozniak A, Kraszewska E, Michej W, Ptaszynski K, Rutkowski P, Sarlomo-Rikala M, Steigen SE, Schneider-Stock R, Stachura J, Chosia M, Ogun G, Ruka W, Siedlecki JA, Miettinen M: Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors. Lab Invest; 2007 Oct;87(10):1029-41
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  • [Title] Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors.
  • Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of gastrointestinal tract.
  • GISTs range from benign indolent neoplasms to highly malignant sarcomas.
  • In this study, we report 36 GIST patients whose tumors had homozygous KIT exon 11 mutations detected by direct sequencing of PCR products.
  • Loss of heterozygosity in KIT locus and other chromosome 4 loci were documented in majority of these tumors.
  • Homozygous KIT exon 11 mutations were found in 33 primary tumors and 7 metastatic lesions.
  • In two cases, shift from heterozygosity to homozygosity was documented during tumor progression being present in metastases, but not in primary tumors.
  • Among primary GISTs, there were 16 gastric, 18 intestinal and 2 from unknown locations.
  • An average primary tumor size was 12 cm and average mitotic activity 32/50 HPFs.
  • Out of 32 tumors 29 (90.6%) with complete clinicopathologic data were diagnosed as sarcomas with more than 50% risk of metastatic disease, and 26 of 29 patients with follow-up had metastases or died of disease.
  • [MeSH-major] Gastrointestinal Stromal Tumors / genetics. Loss of Heterozygosity. Neoplasm Metastasis / genetics. Proto-Oncogene Proteins c-kit / genetics

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  • [CommentIn] Lab Invest. 2008 May;88(5):456-7 [18432212.001]
  • (PMID = 17632543.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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8. Lok KH, Lai L, Yiu HL, Szeto ML, Leung SK: Endosonographic surveillance of small gastrointestinal tumors originating from muscularis propria. J Gastrointestin Liver Dis; 2009 Jun;18(2):177-80
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  • [Title] Endosonographic surveillance of small gastrointestinal tumors originating from muscularis propria.
  • INTRODUCTION: Submucosal tumors (SMT) are not uncommonly found during upper endoscopy.
  • Management for small SMT originating from muscularis propria (MP) is controversial.
  • We report our experience in using EUS to monitor these tumors.
  • Patients with large tumors (maximal diameter > 3 cm), heterogeneous echo pattern, presence of cystic spaces or irregular extra-luminal margin were offered surgery in view of malignant risk.
  • Patients with small tumor and benign EUS features were offered regular EUS surveillance or surgery if they wished.
  • Forty-nine patients had a small tumor and benign EUS features.
  • The histopathological results were low risk gastrointestinal stromal tumor (GIST) in both patients.
  • Three patients (13.0%) showed interval increase in tumor size.
  • CONCLUSION: It remains unclear whether EUS surveillance for small tumors originating from MP in the upper gastrointestinal tract is useful.
  • [MeSH-major] Duodenal Neoplasms / ultrasonography. Endosonography. Esophageal Neoplasms / ultrasonography. Gastrointestinal Stromal Tumors / ultrasonography. Stomach Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Gastric Mucosa / ultrasonography. Humans. Intestinal Mucosa / ultrasonography. Male. Middle Aged. Retrospective Studies. Time Factors. Young Adult

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  • (PMID = 19565047.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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9. Nahal A, Meterissian S: Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma. Am J Clin Oncol; 2009 Aug;32(4):353-5
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  • OBJECTIVES: Soft tissue tumors with dual adipocytic and smooth muscle differentiation are generally rare with most being benign.
  • RESULTS: Based on the literature, lipoleiomyosarcomas favor body cavities and visceral sites although an occurrence in the intestine has been reported.
  • CONCLUSIONS: This is the first reported case of an intestinal lipoleiomyosarcoma.
  • [MeSH-major] Leiomyosarcoma / pathology. Liposarcoma / pathology. Neoplasm Invasiveness / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Colectomy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Middle Aged. Neoplasm Staging. Pelvic Pain / diagnosis. Pelvic Pain / etiology. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19363435.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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10. Schildhaus HU, Merkelbach-Bruse S, Binot E, Büttner R, Wardelmann E: [Inflammatory fibroid polyp: from Vanek's "submucosal granuloma" to the concept of submucosal mesenchymal neoplasia]. Pathologe; 2010 Mar;31(2):109-14
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  • [Title] [Inflammatory fibroid polyp: from Vanek's "submucosal granuloma" to the concept of submucosal mesenchymal neoplasia].
  • IFP represent polypous proliferations of spindle cells in the submucosa and mucosa of the stomach, small bowel and colon with inflammatory infiltration.
  • Therefore, IFP represent true benign mesenchymal tumors of the gastrointestinal tract.
  • [MeSH-major] Eosinophilic Granuloma / pathology. Gastrointestinal Neoplasms / pathology. Leiomyoma / pathology. Polyps / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. DNA Mutational Analysis. Diagnosis, Differential. Gastric Mucosa / pathology. Gastritis / pathology. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology. Helicobacter Infections / genetics. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Intestinal Mucosa / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics. Sequence Analysis, DNA. Sequence Analysis, Protein

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  • (PMID = 20107807.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 23
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11. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA: Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer; 2008;7:94
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  • [Title] Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers.
  • BACKGROUND: Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact.
  • This study aims to pinpoint epigenetic markers that can discriminate between non-malignant and malignant tissue from the large bowel, i.e. markers with diagnostic potential.
  • Possible CIMP tumors were identified by comparing the methylation profile with microsatellite instability (MSI), BRAF-, KRAS-, and TP53 mutation status.
  • RESULTS: The mean number of methylated genes per sample was 0.4 in normal colon mucosa from tumor-free individuals, 1.2 in mucosa from cancerous bowels, 2.2 in adenomas, and 3.9 in carcinomas.
  • The promoters of ADAMTS1, MAL, and MGMT were frequently methylated in benign samples as well as in malignant tumors, independent of microsatellite instability.
  • In contrast, normal mucosa samples taken from bowels without tumor were rarely methylated for the same genes.
  • CONCLUSION: Methylated ADAMTS1, MGMT, and MAL are suitable as markers for early tumor detection.
  • [MeSH-major] Biomarkers, Tumor / analysis. Colonic Neoplasms / genetics. Colonic Neoplasms / pathology. DNA Methylation. Early Detection of Cancer. Genes, Neoplasm. Intestinal Mucosa / metabolism
  • [MeSH-minor] Adenoma / genetics. Adult. Aged. Aged, 80 and over. Cluster Analysis. DNA, Neoplasm / metabolism. Epigenesis, Genetic. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Microsatellite Instability. Microsatellite Repeats / genetics. Middle Aged. Promoter Regions, Genetic. Sex Characteristics

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  • (PMID = 19117505.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2639620
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12. Kiziltaş S, Yorulmaz E, Bilir B, Enç F, Tuncer I: A remarkable intestinal lipoma case. Ulus Travma Acil Cerrahi Derg; 2009 Jul;15(4):399-402
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  • [Title] A remarkable intestinal lipoma case.
  • The small intestine was resected.
  • In conclusion, benign tumors of the small intestine, including intestinal lipomas, should be considered during the diagnostic process of clinical ileus and anemia.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 19669973.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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13. Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW: Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg; 2008 Aug;207(2):210-8
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  • [Title] Tumors of the ampulla of vater: histopathologic classification and predictors of survival.
  • BACKGROUND: The histology and clinical behavior of ampullary tumors vary substantially.
  • We speculated that this might reflect the presence of two kinds of ampullary adenocarcinoma: pancreaticobiliary and intestinal.
  • STUDY DESIGN: We analyzed patient demographics, presentation, survival (mean followup 44 months), and tumor histology for 157 consecutive ampullary tumors resected from 1989 to 2006.
  • RESULTS: There were 33 benign (32 adenomas and 1 paraganglioma) and 124 malignant (118 adenocarcinomas and 6 neuroendocrine) tumors.
  • Size of tumor did not predict survival, nor did cribriform/papillary features, dirty necrosis, apical mucin, or nuclear atypia.
  • Patients with pancreaticobiliary ampullary adenocarcinomas presented with jaundice more often than those with the intestinal kind (p = 0.01) and had worse survival.
  • CONCLUSIONS: In addition to other factors, tumor type (intestinal versus pancreaticobiliary) had a major effect on survival in patients with ampullary adenocarcinoma.
  • Intestinal ampullary adenocarcinomas behaved like their duodenal counterparts, but pancreaticobiliary ones were more aggressive and behaved like pancreatic adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Follow-Up Studies. Humans. Jaundice, Obstructive / mortality. Jaundice, Obstructive / pathology. Jaundice, Obstructive / surgery. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Risk Factors

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  • (PMID = 18656049.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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14. Kala Z, Kysela P, Meluzinova H: Small-bowel tumors in the elderly 65+ years: 10 years of experience. Z Gerontol Geriatr; 2008 Oct;41(5):403-7
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  • [Title] Small-bowel tumors in the elderly 65+ years: 10 years of experience.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work represents a prospective evaluation of a diagnostic and therapeutic algorithm in the management of the small-intestine tumor below the ligamentum Treitzi in patients over 65 years of age.
  • RESULTS: A population of 96 patients who underwent surgery for a small-intestinal tumor in our hospital from 1996 to 2006 is presented.
  • Ultrasound of the small intestine was sufficient to make the diagnosis in 21 of them.
  • CONCLUSION: The small-bowel ultrasound can be recommended as the first choice method.
  • All complaints regarding the gastrointestinal tract should be verified.
  • [MeSH-major] Intestinal Neoplasms / surgery. Intestinal Neoplasms / ultrasonography. Intestine, Small / surgery. Intestine, Small / ultrasonography. Ultrasonography / methods

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  • (PMID = 18327695.001).
  • [ISSN] 0948-6704
  • [Journal-full-title] Zeitschrift für Gerontologie und Geriatrie
  • [ISO-abbreviation] Z Gerontol Geriatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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15. Thakur ML, Devadhas D, Zhang K, Pestell RG, Wang C, McCue P, Wickstrom E: Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products. J Nucl Med; 2010 Jan;51(1):106-11
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  • [Title] Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products.
  • Despite the great strides made in imaging breast cancer (BC) in humans, the current imaging modalities miss up to 30% of BC, do not distinguish malignant lesions from benign ones, and require histologic examinations for which invasive biopsy must be performed.
  • Annually in the United States, approximately 5.6 million biopsies find benign lesions.
  • RT-PCR on excised tumors determined VPAC1 expression, and histology ascertained the pathology.
  • RESULTS: Ten tumors were detected by PET.
  • Four tumors were detected both by (18)F-FDG and by (64)Cu-TP3805.
  • Additionally, 4 tumors were imaged with (64)Cu-TP3805 only.
  • These 8 tumors overexpressed VPAC1 receptors and were malignant by histology.
  • The 2 remaining tumors were visualized with (18)F-FDG only.
  • These tumors did not express the VPAC1 oncogene product and had benign histology.
  • The 2 benign tumors that did not express the VPAC1 receptor were not imaged. (64)Cu-TP3805 promises to have the potential for the early and accurate imaging of primary and metastatic BC.
  • [MeSH-major] Mammary Neoplasms, Experimental / metabolism. Mammary Neoplasms, Experimental / radionuclide imaging. Organometallic Compounds. Pituitary Adenylate Cyclase-Activating Polypeptide. Radiopharmaceuticals / chemical synthesis. Receptors, Vasoactive Intestinal Polypeptide, Type I / biosynthesis
  • [MeSH-minor] Animals. Chromatography, High Pressure Liquid. Female. Fluorodeoxyglucose F18 / pharmacokinetics. Half-Life. Humans. Image Processing, Computer-Assisted. Mammary Tumor Virus, Mouse / genetics. Mice. Positron-Emission Tomography. Quality Control. Reverse Transcriptase Polymerase Chain Reaction. Tomography, X-Ray Computed

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  • (PMID = 20008985.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA- S10RR 023709; United States / NCI NIH HHS / CA / CA-RO1-109231; United States / NIBIB NIH HHS / EB / EB-RO1-001809; United States / NCI NIH HHS / CA / P30 CA56036; United States / PHS HHS / / RP-RO1-023709
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organometallic Compounds; 0 / Pituitary Adenylate Cyclase-Activating Polypeptide; 0 / Radiopharmaceuticals; 0 / Receptors, Vasoactive Intestinal Polypeptide, Type I; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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16. Groen EJ, Roos A, Muntinghe FL, Enting RH, de Vries J, Kleibeuker JH, Witjes MJ, Links TP, van Beek AP: Extra-intestinal manifestations of familial adenomatous polyposis. Ann Surg Oncol; 2008 Sep;15(9):2439-50
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  • [Title] Extra-intestinal manifestations of familial adenomatous polyposis.
  • Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene.
  • Although the development of colorectal cancer stands out as the most prevalent complication, FAP is a multisystem disorder of growth.
  • Thus, clinicians that care for and counsel members of high-risk families should have familiarity with all the extra-intestinal manifestations of this syndrome.
  • Affected individuals can develop thyroid and pancreatic cancer, hepatoblastomas, CNS tumors (especially medulloblastomas), and various benign tumors such as adrenal adenomas, osteomas, desmoid tumors and dental abnormalities.
  • We present a clinical overview of extra-intestinal manifestations, including management and treatment options for the FAP syndrome.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Neoplasms / diagnosis

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  • (PMID = 18612695.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
  • [Number-of-references] 111
  • [Other-IDs] NLM/ PMC2518080
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17. Pohl PP, Meyer A, Lammers BJ, Goretzki PE: [Abdominal preoperation. No contraindication for laparoscopic transabdominal adrenalectomy]. Chirurg; 2008 Jun;79(6):571-5
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  • Benign adrenal gland tumors smaller than 6 cm are nowadays the indication for minimally invasive surgery.
  • Intestinal adhesions could be a contraindication against transabdominal laparoscopic adrenalectomy, and therefore the retroperitoneoscopic approach could be an advantage in these cases.
  • [MeSH-major] Abdomen / surgery. Adrenal Gland Neoplasms / surgery. Adrenalectomy / contraindications. Adrenocortical Adenoma / surgery. Carcinoma / surgery. Cushing Syndrome / surgery. Laparoscopy / contraindications. Pheochromocytoma / surgery

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  • (PMID = 17879074.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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18. Xia SY, Li R, Song SB, Liang FQ: [Diagnosis and surgical therapy of primary retroperitoneal neurogenic tumors]. Zhonghua Yi Xue Za Zhi; 2009 Jun 9;89(22):1567-9
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  • [Title] [Diagnosis and surgical therapy of primary retroperitoneal neurogenic tumors].
  • OBJECTIVE: To explore the diagnosis and surgical therapy for retroperitoneal neurogenic tumors (PRNTs).
  • METHODS: The clinical records of 79 surgically treated patients with retroperitoneal neurogenic tumor were retrospectively analyzed.
  • Pathological analysis identified 19 patients with neurofibroma, 8 with neurilemmoma, 4 with paraganglioma, 21 with neurofibrosarcoma, 14 with malignant neurilemmoma, 6 with malignant paraganglioma, 5 with neuroectodermal tumor and 2 with neuroblastoma.
  • The mortality rate of PRNT operation is was 1.3%, 3-year recurrence rate of benign tumor 0%, 5-year recurrence rate of benign tumor 12.9%, reoperation rate 100%, 5-year survival rate 100%.
  • 3 years recurrence rate of malignancy tumor 41.6%, reoperation rate 90%, 5 years recurrence rate of malignancy tumor 79.1% and 5 years survival rate is 62.5%.
  • Pre-operative preparation of intestinal tract and blood, maintaining the intactness of involved nerve are important for tumor resection.
  • To prevent tumor recurrence, the key surgical techniques are to minimize tumor residues and .
  • [MeSH-major] Neuroectodermal Tumors / diagnosis. Neuroectodermal Tumors / surgery. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / surgery

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  • (PMID = 19953887.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Hart WR: Borderline epithelial tumors of the ovary. Mod Pathol; 2005 Feb;18 Suppl 2:S33-50
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  • [Title] Borderline epithelial tumors of the ovary.
  • The concept and terminology of borderline epithelial tumors of the ovary have been controversial for over a century, in spite of the acceptance of a borderline category in almost all current classifications of ovarian tumors.
  • Typically, borderline tumors are noninvasive neoplasms that have nuclear abnormalities and mitotic activity intermediate between benign and malignant tumors of similar cell type.
  • Borderline tumors of all surface epithelial cell types have been studied.
  • The most common and best understood are serous borderline tumors and mucinous borderline tumors of intestinal type, which are the subject of this review.
  • Some of the most challenging issues for serous tumors include: the criteria and clinical behavior of stromal microinvasion; the high prevalence of synchronous extraovarian disease; the classification and histopathologic features of associated peritoneal tumor implants, especially invasive implants; and, the prognostic significance of micropapillary tumors.
  • The mucinous borderline tumors of intestinal type have a different set of considerations, including: their frequently heterogeneous composition with coexisting benign, borderline and malignant elements; the classification and significance of accompanying noninvasive carcinoma; the recognition of stromal invasion, including microinvasion and expansile invasion; and, the historically misunderstood relationship to pseudomyxoma peritonei.
  • All of these issues are discussed in this presentation, as are the important gross and microscopic features of serous and mucinous borderline tumors and pertinent information on their treatment and prognosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 15761465.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 93
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20. Alsaad KO, Serra S, Schmitt A, Perren A, Chetty R: Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix. Endocr Pathol; 2007;18(1):16-22
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  • Goblet cell carcinoid (GCC) of the vermiform appendix is an uncommon neoplasm and its histogenesis is controversial.
  • Little is known about the immunohistochemical expression of cytokeratins 7 (CK7) and 20 (CK20) in appendiceal neuroendocrine tumors.
  • The tumors were also evaluated for Ki-67 proliferation index, mitotic activity, tumor necrosis, extracellular pools of mucin, obvious intestinal type adenocarcinomatous foci, angiolymphatic permeation, perineural/neural infiltration, and the depth of invasion of the appendix wall.
  • Immunohistochemically, all 17 (100%) of GCC exhibited strong and diffuse immunopositivity for CK20, whereas expression of CK7 was present in 12 cases (70.5%), ranging from 5 to 50% of tumor cells being labeled.
  • On the other hand, 25 cases of classical carcinoid tumors were consistently negative for CK7; however, 4 cases (16%) showed immunolabeling for CK20 in 25-50% of the tumor cells.
  • Goblet cell carcinoid should be regarded as a crypt cell or an amphicrine carcinoma rather than a variant of carcinoid tumor, a lesion that has benign connotations.
  • [MeSH-major] Appendiceal Neoplasms / metabolism. Carcinoid Tumor / metabolism. Goblet Cells / metabolism. Keratin-20 / metabolism. Keratin-7 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Proliferation. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17652796.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Keratin-7; 0 / Ki-67 Antigen
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21. Jwo SC, Chien RN, Chao TC, Chen HY, Lin CY: Clinicopathological features, surgical management, and disease outcome of perforated gastric cancer. J Surg Oncol; 2005 Sep 15;91(4):219-25
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  • Disease outcomes were analyzed in-depth based on tumor stage, depth of tumor invasion, operative curability, and three treatment groups.
  • The remaining five patients were misdiagnosed as having benign gastric perforation and underwent local surgery; these patients were assigned to Group 3.
  • The survival rates for Stage I disease (P = 0.0342), T1/T2 tumors (P = 0.0342), and curative resection (P = 0.0012) significantly exceeded those of Stage III/IV, T3/T4 tumors, and non-curative resection.
  • [MeSH-major] Gastrectomy. Intestinal Perforation / etiology. Stomach / injuries. Stomach Neoplasms / complications. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Palliative Care. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16121341.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Alexander AA, Patel AA, Odland R: Paranasal sinus osteomas and Gardner's syndrome. Ann Otol Rhinol Laryngol; 2007 Sep;116(9):658-62
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  • OBJECTIVES: Osteomas are common benign tumors of the paranasal sinuses.
  • Osteomas are also seen as part of Gardner's syndrome, an autosomal dominant disease characterized by intestinal polyposis, osteomas, and cutaneous and soft tissue tumors.
  • Suspected patients should have a complete workup for Gardner's syndrome, including lower gastrointestinal tract endoscopy, barium enema imaging, and DNA testing.
  • [MeSH-major] Gardner Syndrome / complications. Osteoma / complications. Paranasal Sinus Neoplasms / complications

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  • (PMID = 17926587.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Zhang L, Chen YJ, Shang CZ, Zhong F, Zhang HW, Chen JS: [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Jul;10(4):356-8
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  • [Title] [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases].
  • OBJECTIVE: To summarize the pathological classification, clinical symptom and experience in the diagnosis and treatment of primary tumor of small intestine.
  • METHODS: Data of 58 patients with primary tumor of small intestine pathologically confirmed from Oct.
  • RESULTS: Thirteen patient (22.4%) had primary benign tumors of small intestine and 45 patient (77.6%) had primary malignant tumors of small intestine.
  • The major clinical signs of primary tumor of small intestine included hemorrhage(85%), abdomen pain(19%), abdomen mass and intestine obstruction(16%).
  • CONCLUSIONS: Primary tumors of small intestine are difficult to be diagnosed preoperatively.
  • Laparotomy of abdominal cavity is the main choice for those patients with suspicious tumor of small intestine.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 17659462.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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24. Nonose R, Priolli DG, Cardinalli IA, Máximo FR, Galvão PS, Martinez CA: Epithelioid hemangioma of the colon: a case report. Sao Paulo Med J; 2008 Sep;126(5):294-6
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  • CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon benign vascular neoplasm that is usually located on the face or neck.
  • Two months after the condition started, she began to present changes in her intestinal habit, with evacuations containing blood and mucus and a weight loss of 4 kg over this period.
  • Neoplasia of the colon was clinically suspected and she underwent colonoscopy.
  • It occupied 80% of the intestinal lumen.
  • A biopsy collected during the examination suggested a diagnosis of neoplasia of vascular origin.
  • Despite the rarity of neoplasia of vascular origin, this possibility should be considered in the differential diagnosis for colorectal tumors.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Colon / pathology. Hemangioma / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 19099166.001).
  • [ISSN] 1806-9460
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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25. Babich JP, Klein J, Friedel DM: Endoscopic removal of a brunneroma with EUS guidance. South Med J; 2010 Mar;103(3):250-2
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  • The most common benign tumors of the small intestine are adenoma, and 25% of these occur in the duodenum.
  • Among the benign tumors of the duodenum, 30-50% arise from the Brunner glands.
  • Most of the literature describes their presentations as ranging from benign, nonspecific, epigastric discomfort to obstruction and intestinal bleeding.
  • [MeSH-major] Adenoma / surgery. Brunner Glands / surgery. Duodenal Neoplasms / surgery. Duodenoscopy / methods

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  • (PMID = 20134393.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Schwartz GD, Barkin JS: Small-bowel tumors detected by wireless capsule endoscopy. Dig Dis Sci; 2007 Apr;52(4):1026-30
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  • [Title] Small-bowel tumors detected by wireless capsule endoscopy.
  • Small bowel tumors are difficult to diagnose because of their endoscopic inaccessibility.
  • The purpose of this report is to describe the largest series of patients with small bowel tumors detected by capsule endoscopy.
  • Eighty six patients were derived from the Given Imaging clinical database on a survey of Pillcam SB capsule users who were diagnosed with 87 small bowel tumors, 1 cecal tumor, and 1 gastric tumor.
  • All patients have histologically confirmed tumors.
  • Malignant tumors comprised 61% (54/89) and benign 39% (35/89).
  • Of the 87 reported small bowel tumors, 4 were identified in the duodenum, 43 tumors were identified in the jejunum, 18 tumors were identified in the ileum, and 22 tumors were located in the mid to distal small bowel.
  • The most common malignant tumors were adenocarcinoma, carcinoids, melanomas, lymphomas, and sarcomas.
  • The most common benign tumors were GIST, hemangiomas, hamartomas, adenomas, and granulation tissue polyps.
  • Capsule endoscopy is the diagnostic procedure of choice in patients with suspected small bowel tumors.
  • [MeSH-major] Capsule Endoscopy. Endoscopy, Gastrointestinal. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 17380403.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Celiński K, Cichoz-Lach H: Therapeutic endoscopy in gastroenterology. J Physiol Pharmacol; 2007 Aug;58 Suppl 3:33-41
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  • Endoscopic decompression of the biliary tree - dilatation benign structures of the biliary tree with baloon catheters and placement an internal endoprothesis allows the nonoperative decompression and significant palliation for patients with obstructing tumors.
  • [MeSH-minor] Colonic Polyps / surgery. Hemostasis, Endoscopic / methods. Humans. Intestinal Mucosa / surgery. Photochemotherapy / methods

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  • (PMID = 17901581.001).
  • [ISSN] 0867-5910
  • [Journal-full-title] Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • [ISO-abbreviation] J. Physiol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 50
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28. Yang WL, Zhang XC, Yan ZQ, Zhang HM, Zhao Z, Zhang JG, Wang YJ: [Clinical analysis of primary small intestinal neoplasms in 305 cases]. Zhonghua Zhong Liu Za Zhi; 2007 Oct;29(10):781-3
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  • [Title] [Clinical analysis of primary small intestinal neoplasms in 305 cases].
  • OBJECTIVE: To summarive the experience in diagnosis and treatment of primary small intestinal neoplasm.
  • METHODS: The data of 305 patients with pathologically confirmed primary small intestinal tumor collected from 6 hospitals around the Songhua River during the past 33 years were analyzed retrospectively.
  • RESULTS: There were 42 benign and 263 malignant tumors in this series with a ratio of 1: 6.26.
  • The 263 malignant tumors in this series consisted of 135 adenocarcinomas, 57 malignant stromal tumors, 37 malignant lymphomas, 20 carcinoids, and etc.
  • Chronic occult bleeding, gradual of body weight loss and mild abdominal pain (three obscurities) were the common clinical features and alerting massage of intestinal tumor.
  • Correct preoperative diagnostic rate was only 57.0% (174/305) due to difficulty in early diagnosis, which was 67.2% (92/137) in the duodenal tumors, and 51.9% (82/168) in the jejunoileal tumors.
  • All of the 42 benign tumors were resected completely.
  • For the 263 patients with malignant tumors, radical dissection was performed in 153, palliative resection in 34, and gut by-pass or biopsy in 76.
  • The median survival of the patients who underwent radical resection of their malignant tumors was 92 months, which was significantly higher than that of the other groups.
  • CONCLUSION: Early diagnosis of primary small intestinal tumors is difficult and with a preoperative misdiagnosis rate of 43.0%.
  • Total intestinal barium swallowing, endoscopy and superior mesenteric arteriography are three critical examinations for diagnosis and location.
  • The primary small intestinal tumor should be resected as early as possible if no distant metastasis is detected.
  • [MeSH-major] Adenocarcinoma. Diagnostic Errors. Digestive System Surgical Procedures / methods. Duodenal Neoplasms
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / diagnosis. Carcinoid Tumor / secondary. Carcinoid Tumor / surgery. Female. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / secondary. Gastrointestinal Stromal Tumors / surgery. Humans. Ileal Neoplasms / diagnosis. Ileal Neoplasms / pathology. Ileal Neoplasms / surgery. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lymphatic Metastasis. Lymphoma / diagnosis. Lymphoma / pathology. Lymphoma / surgery. Male. Middle Aged. Young Adult

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  • (PMID = 18396694.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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29. Ha CY, Shah R, Chen J, Azar RR, Edmundowicz SA, Early DS: Diagnosis and management of GI stromal tumors by EUS-FNA: a survey of opinions and practices of endosonographers. Gastrointest Endosc; 2009 May;69(6):1039-44.e1
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  • [Title] Diagnosis and management of GI stromal tumors by EUS-FNA: a survey of opinions and practices of endosonographers.
  • BACKGROUND: There is no consensus regarding the best management strategy for diagnosing and treating GI stromal tumors (GISTs).
  • A total of 92% use size as the main criterion to distinguish benign from malignant GISTs, and 90% refer lesions >5 cm for surgery.
  • [MeSH-major] Biopsy, Fine-Needle. Endosonography. Gastrointestinal Neoplasms / pathology. Gastrointestinal Neoplasms / ultrasonography. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / ultrasonography. Ultrasonography, Interventional
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Health Care Surveys. Humans. Internet. Intestinal Mucosa / pathology. Practice Patterns, Physicians'. Predictive Value of Tests. Proto-Oncogene Proteins c-kit / analysis. Referral and Consultation

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  • [CommentIn] Gastrointest Endosc. 2010 May;71(6):1102; author reply 1102-3 [20438905.001]
  • (PMID = 19410040.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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30. Guillen-Ahlers H, Suckow MA, Castellino FJ, Ploplis VA: Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PLoS One; 2010 Feb 05;5(2):e9070
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  • [Title] Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.
  • BACKGROUND: Fas, a member of the tumor necrosis family, is responsible for initiating the apoptotic pathway when bound to its ligand, Fas-L.
  • One of the main limitations of the Apc(Min/+) mouse model is that it only develops benign polyps.
  • However, Apc(Min/+)/Fas(lpr) mice presented with a dramatic increase in tumor burden relative to Apc(Min/+) mice and invasive lesions at advanced ages.
  • CONCLUSIONS/SIGNIFICANCE: This study demonstrated that imposition of a Fas deletion in an Apc(Min/+) background results in a more aggressive phenotype of the Apc(Min/+) mouse model, with more rapid development of invasive intestinal tumors and a decrease in Fas-L levels.

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  • (PMID = 20140201.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / P01 HL073750; United States / NHLBI NIH HHS / HL / HL 73750
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Antigens, CD95; 0 / Fas Ligand Protein; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2816700
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31. de Vries JJ, Vogten JM, de Bruin PC, Boerma D, van de Pavoordt HD, Hagendoorn J: Mesenterical lymphangiomatosis causing volvulus and intestinal obstruction. Lymphat Res Biol; 2007;5(4):269-73
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  • [Title] Mesenterical lymphangiomatosis causing volvulus and intestinal obstruction.
  • Lymphangiomas are benign tumors consisting of lymphatic vasculature that generally occur in the skin and soft tissues.
  • Rarely, lymphangiomas occur in the gastrointestinal tract.
  • Here, we report a case of a 13-year-old girl presenting with an intestinal obstruction.
  • [MeSH-major] Intestinal Neoplasms / pathology. Intestinal Obstruction / etiology. Intestinal Volvulus / etiology. Lymphangioma / pathology. Mesentery / pathology

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  • (PMID = 18370918.001).
  • [ISSN] 1539-6851
  • [Journal-full-title] Lymphatic research and biology
  • [ISO-abbreviation] Lymphat Res Biol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Galimberti A, Compagnoni BM, Lezziero F, Grassi M, Gariboldi M, Ferrante F: [Gastrointestinal stromal tumours and acute haemorrhage: description of four cases]. Chir Ital; 2005 May-Jun;57(3):337-43
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  • [Transliterated title] Tumori stromali del tratto gastroenterico ed emorragia acuta: descrizione di quattro casi.
  • Gastrointestinal stromal tumours are uncommon neoplasias arising from stromal tissue of the intestinal wall.
  • The clinical symptoms of gastrointestinal stromal tumours are related to tumour size and are generally aspecific: acute or chronic bleeding, abdominal pain and palpable mass are some of the most common signs.
  • In the absence of metastases, it is quite difficult to distinguish between benign and malignant lesions.
  • The most important prognostic factors are number of mitoses and tumour size.
  • [MeSH-major] Duodenal Neoplasms / surgery. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Hemorrhage / surgery. Gastrointestinal Stromal Tumors / complications. Gastrointestinal Stromal Tumors / surgery. Stomach Neoplasms / surgery


33. Ouban A, Ahmed AA: Claudins in human cancer: a review. Histol Histopathol; 2010 01;25(1):83-90
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  • The claudins are present in variety of normal tissues, hyperplastic conditions, benign neoplasms, and cancers that exhibit epithelial differentiation.
  • Examples include the use of immunohistochemical detection of claudins to differentiate between oncocytoma and chromophobe renal cell carcinoma, endometrial endometrioid carcinoma and seropapillary carcinoma, mesothelioma and metastatic adenocarcinoma, hepatocellular and biliary tract carcinomas, and between intestinal-type and diffuse-type gastric carcinoma.
  • Thus, it seems that attempts to identify expression claudins in cancers are becoming increasingly useful in histologic diagnosis of tumors as well as means to assess patient's prognosis.
  • [MeSH-major] Claudins / metabolism. Neoplasms / metabolism. Neoplasms / pathology

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  • (PMID = 19924644.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Claudins
  • [Number-of-references] 63
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34. Sibio S, Borrini F, Sammartino P, Accarpio F, Biacchi D, Caprio G, Iafrate F, Baccheschi AM, Cornali T, Di Giorgio A: Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features. Endocr Pathol; 2010 Sep;21(3):199-203
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  • [Title] Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features.
  • Brenner tumor and struma ovarii, two uncommon ovarian tumors arising alone or together with dermoid cysts or adenomas, are both rare entities.
  • Both tumors rarely become malignant and rarely metastasize.
  • Few published reports describe coexisting Brenner tumor and malignant struma ovarii.
  • The patient we describe, a 74-year-old woman, presented with a 2 months' history of lower abdominal pain and episodic intestinal subocclusion due to a complex pelvic mass.
  • The mass consisted predominantly of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that had undergone malignant transformation into a well-differentiated papillary carcinoma and also normal thyroid tissue that had spread to the peritoneum.
  • [MeSH-major] Brenner Tumor / pathology. Carcinoma, Papillary / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary. Struma Ovarii / secondary
  • [MeSH-minor] Aged. Breast Neoplasms / complications. Carcinoma, Ductal, Breast / complications. Female. Humans. Neoplasms, Second Primary / pathology. Tomography, X-Ray Computed

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  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Dultz LA, Ullery BW, Sun HH, Huston TL, Eachempati SR, Barie PS, Shou J: Ileocecal valve lipoma with refractory hemorrhage. JSLS; 2009 Jan-Mar;13(1):80-3
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  • BACKGROUND: Lipomas are the most common benign mesenchymal tumors of the gastrointestinal tract, with the colon being the most prevalent site.
  • Intestinal lipomas are usually asymptomatic.
  • Tumors >2 cm in diameter may occasionally cause nonspecific symptoms, including change in bowel habits, abdominal pain, or rectal bleeding, but with resection the prognosis is excellent.

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  • (PMID = 19366548.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3015905
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36. Koay MH, Goh YW, Iacopetta B, Grieu F, Segal A, Sterrett GF, Platten M, Spagnolo DV: Gastrointestinal stromal tumours (GISTs): a clinicopathological and molecular study of 66 cases. Pathology; 2005 Feb;37(1):22-31
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  • AIMS: Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established.
  • (1) appropriate morphology, (2) CD117 positivity, (3) adequacy of pathological material for study, and (4) exclusion of other tumour types on the basis of immunophenotypic and/or ultrastructural features.
  • Tumours were mostly located in the stomach (67%) and small intestine (SI; 25%).
  • c-kit mutations were found in 69% of GISTs, with the large majority (91%) occurring in exon 11.
  • Size > or = 10 cm, tumour necrosis and pure epithelioid cell morphology each were the only factors significantly associated with adverse survival (p=0.038, and p=0.047 and p=0.028, respectively).
  • c-kit mutations were more frequent in small intestinal GISTs (p=0.05) and in those with pure spindle cell morphology (p=0.023) but were not associated with patient outcome.
  • CD117 staining of any mesenchymal lesion of the gastrointestinal tract should be mandatory for accurate classification.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 15875730.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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37. Moldovan B, Copotoiu C, Bud V, Serac G, Nemeş I, Toma L, Mureşan A, Florea S, Cornăţeanu S, Milutin D, Balmoş I, Azoulay D: [Vascular exclusion of the liver: surgical technique and initial clinical experience]. Chirurgia (Bucur); 2007 Mar-Apr;102(2):175-83
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  • The indications of the technique are voluminous center located liver tumors, multiple liver tumors, tumors in contact with hepatic veins or with hilum bifurcation.
  • Preoperative diagnosis were: 2 right liver voluminous benign tumors (hemangiomas), 5 cases of colo-rectal metastasis and one resection for metastases of gastro-intestinal stromal tumor.
  • [MeSH-major] Hemostasis, Surgical / methods. Hepatectomy / methods. Liver Neoplasms / surgery

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  • (PMID = 17615919.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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38. Tivadar B, Serban B, Mircea M, Tivadar B Jr, Leonard A, Daniela P, Simona M: Late hepatic metastasis in the evolution of gastrointestinal stromal tumors. Hepatogastroenterology; 2010 Jan-Feb;57(97):95-7
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  • [Title] Late hepatic metastasis in the evolution of gastrointestinal stromal tumors.
  • Gastro-intestinal stromal tumours develop in the digestive tract wall, in the undifferentiated mesenchymal cells with a starting point at the level of the interstitial cells of Cajal.
  • Gastro-intestinal stromal tumours often lead to peritoneal and hepatic metastasis.
  • A special attention should be paid to localization, serosal invasion, mucous ulceration, size of the tumor and mitotic index, in order to set the prognosis of the patient.
  • We here by present two cases of gastro-intestinal stromal tumours one with gastric location and one jejunal tumor with ulceration and hemorrhage, of small sizes, initially diagnosed as benign but developing in the late evolution liver metastases.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology. Jejunal Neoplasms / pathology. Leiomyoma / pathology. Liver Neoplasms / secondary. Stomach Neoplasms / pathology


39. Jang JY, Park YC, Song YS, Lee SE, Hwang DW, Lim CS, Lee HE, Kim WH, Kim SW: Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas. J Hepatobiliary Pancreat Surg; 2009;16(5):668-74
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  • [Title] Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas.
  • PURPOSE: The purpose of this study was to document the biological changes during the progression of intraductal papillary mucinous neoplasm of the pancreas (IPMN) and to identify biological markers capable of differentiating benign and malignant IPMN.
  • The paraffin-embedded tumors from 27 with benign IPMNs and from 14 with IPMCs were subjected to immunohistochemical staining and DNA extraction.
  • RESULTS: K-ras mutations at codon 12 and 13 were detected in 13 of 37 (38.2%) of the IPMNs: in 5 of 24 (20.8%) of benign IPMNs, and in 8 of 13 (61.5%) of malignant IPMNs (p = 0.028).
  • S100A4 was expressed in 2 (7.4%) of 27 benign IPMNs, and 6 (42.9%) of 14 malignant IPMNs (p = 0.007).
  • MUC2 was expressed in 2 (7.4%) benign IPMNs, and in 9 (64.3%) malignant IPMNs (p < 0.001).
  • CONCLUSION: K-ras mutation and the expression of S100A4 and MUC2 (especially in intestinal subtype) were found to be related to malignancy in IPMN, and may be useful for the diagnosis and for assessing the biological behavior of IPMN.
  • [MeSH-major] Biomarkers, Tumor / genetics. Carcinoma, Pancreatic Ductal / genetics. Mucin-2 / genetics. Pancreatic Neoplasms / genetics. S100 Proteins / metabolism
  • [MeSH-minor] Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Genes, ras. Humans. Immunohistochemistry. Male. Middle Aged. Mutation. Neoplasm Staging. Polymerase Chain Reaction. Probability. Prognosis. Retrospective Studies. Statistics, Nonparametric. Survival Rate

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  • (PMID = 19412570.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-2; 0 / S100 Proteins
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40. Tamura H, Ohtsuka M, Washiro M, Kimura F, Shimizu H, Yoshidome H, Kato A, Seki N, Miyazaki M: Reg IV expression and clinicopathologic features of gallbladder carcinoma. Hum Pathol; 2009 Dec;40(12):1686-92
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  • Regenerating islet-derived family, member 4 (Reg IV) has been shown to be associated with colorectal carcinogenesis and gastric carcinogenesis through intestinal metaplasia.
  • Immunohistochemically, although only a small part of the epithelium with intestinal metaplasia in 2 of 4 cases with adenomyomatosis showed Reg IV expression, Reg IV was negative in all cases with normal gallbladder (n = 15) and cholelithiasis (n = 13).
  • Expression was more frequently observed in well to moderately differentiated than in poorly differentiated adenocarcinomas and significantly correlated with expression of caudal-related homeobox transcription factor (a candidate for involvement in the induction of intestinal metaplasia).
  • Before surgical resection, 4 (33%) of 12 patients with gallbladder carcinoma had high serum Reg IV levels, whereas Reg IV was never elevated in 12 patients with benign diseases.
  • The serum levels of Reg IV decreased after surgical resection of the tumors.
  • These results suggest that Reg IV is involved in gallbladder carcinoma carcinogenesis through intestinal metaplasia and is associated with relatively favorable prognosis in patients after surgery.
  • The serum level of Reg IV may be of use or indicative of neoplasia.
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Lectins, C-Type / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Enzyme-Linked Immunosorbent Assay. Gene Expression. Homeodomain Proteins / biosynthesis. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Metaplasia / genetics. Metaplasia / metabolism. Metaplasia / pathology. Neoplasm Staging. Prognosis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19716164.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Lectins, C-Type; 0 / REG4 protein, human
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41. Falguières T, Maak M, von Weyhern C, Sarr M, Sastre X, Poupon MF, Robine S, Johannes L, Janssen KP: Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool. Mol Cancer Ther; 2008 Aug;7(8):2498-508
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  • [Title] Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool.
  • The targeting of solid tumors requires delivery tools that resist intracellular and extracellular inactivation, and that are taken up specifically by tumor cells.
  • We have shown previously that the recombinant nontoxic B-subunit of Shiga toxin (STxB) can serve as a delivery tool to target digestive tumors in animal models.
  • Tissue samples of normal colon, benign adenomas, colorectal carcinomas, and liver metastases from 111 patients were obtained for the quantification of the expression of the cellular STxB receptor, the glycosphingolipid globotriaosyl ceramide (Gb(3) or CD77).
  • We found that compared with normal tissue, the expression of Gb(3) was strongly increased in colorectal adenocarcinomas and their metastases, but not in benign adenomas.
  • Of a given tumor sample, on average, 80% of the cells could visibly bind STxB, and upon incubation at 37 degrees C, STxB was transported to the Golgi apparatus, following the retrograde route.
  • This STxB-specific intracellular targeting allows the molecule to avoid recycling and degradation, and STxB could consequently be detected on tumor cells even 5 days after initial uptake.
  • In conclusion, the targeting properties of STxB could be diverted for the delivery of contrast agents to human colorectal tumors and their metastases, whose early detection and specific targeting remains one of the principal challenges in oncology.
  • [MeSH-major] Antigens, Tumor-Associated, Carbohydrate / biosynthesis. Colorectal Neoplasms / therapy. Intestines / microbiology. Shiga Toxins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromatography, Thin Layer. Female. Humans. Liver Neoplasms / metabolism. Liver Neoplasms / secondary. Male. Middle Aged. Trihexosylceramides / biosynthesis

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  • (PMID = 18687997.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Gb3 antigen; 0 / Shiga Toxins; 0 / Trihexosylceramides; 0 / stxB toxin; 71965-57-6 / globotriaosylceramide
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42. Vereczkey I, Tóth E, Orosz Z: [Diagnostic problems of ovarian mucinous borderline tumors]. Magy Onkol; 2009 Jun;53(2):127-33
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  • [Title] [Diagnostic problems of ovarian mucinous borderline tumors].
  • About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors.
  • The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians.
  • These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas.
  • The borderline tumors occur most commonly in childbearing age, and show an indolent course.
  • To diagnose the intraepithelial carcinoma, to detect the microinvasion and the expansive invasion in a mucinous borderline tumor, to differentiate from the metastasis of colorectal tumors may be very problematic in the majority of the cases.
  • Eleven cases diagnosed as mucinous borderline ovarian tumor in our institute from 2000 to 2008 were reviewed.
  • Eight out of 11 were intestinal type while three were cervical (mullerian) type.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Biomarkers, Tumor / analysis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. CA-125 Antigen / analysis. Diagnosis, Differential. Female. GPI-Linked Proteins. Homeodomain Proteins / analysis. Humans. Keratin-20 / analysis. Keratin-7 / analysis. Membrane Glycoproteins / analysis. Middle Aged. Neoplasm Invasiveness. Prognosis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis

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  • (PMID = 19581178.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CDX2 protein, human; 0 / GPI-Linked Proteins; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7; 0 / Membrane Glycoproteins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / mesothelin
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43. Schildhaus HU, Büttner R, Binot E, Merkelbach-Bruse S, Wardelmann E: [Inflammatory fibroid polyps are true neoplasms with PDGFRA mutations]. Pathologe; 2009 Dec;30 Suppl 2:117-20
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  • [Title] [Inflammatory fibroid polyps are true neoplasms with PDGFRA mutations].
  • AIMS: Inflammatory fibroid polyps (IFP) are proliferations of CD34-positive spindle cells in the submucosa and mucosa of the gastrointestinal tract with an inflammatory infiltrate.
  • IFP occur in the stomach, small bowel, colon and esophagus.
  • METHODS: A total of 29 IFP originating in the stomach, small bowel and colon were examined immunohistochemically, and mutational analyses of PDGFRA exons 10, 12, 14 and 18 were conducted.
  • The mutational types are related to mutations known from gastrointestinal stromal tumors (GIST).
  • Our data indicate that IFP are true neoplasms (true benign tumors) and not reactive lesions.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. DNA Mutational Analysis. Gastroenteritis / genetics. Gastrointestinal Neoplasms / genetics. Granuloma, Plasma Cell / genetics. Intestinal Polyps / genetics. Polyps / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Antigens, CD34 / genetics. Cell Division / genetics. Exons / genetics. Female. Gastric Mucosa / pathology. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology. Gene Expression Regulation, Neoplastic / genetics. Humans. Intestinal Mucosa / pathology. Male. Mucous Membrane / pathology. Neoplasm Invasiveness / pathology. Polymerase Chain Reaction. Polymorphism, Genetic / genetics

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  • (PMID = 19756614.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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44. Bailey AA, Debinski HS, Appleyard MN, Remedios ML, Hooper JE, Walsh AJ, Selby WS: Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience. Am J Gastroenterol; 2006 Oct;101(10):2237-43
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  • [Title] Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience.
  • OBJECTIVE: The objective of the study was to examine diagnosis and outcome in a series of patients with small bowel tumors detected by capsule endoscopy (CE) in three Australian centers.
  • METHODS: Review of prospectively collected data from 416 CEs identified 27 tumors in 26 patients.
  • Clinical parameters, tumor histology, and follow-up are reported.
  • RESULTS: Twenty-seven tumors were identified in 26 patients (mean age 61 +/- 13.7 yr).
  • Indications for CE were obscure gastrointestinal (GI) bleeding (21), suspected tumor (3), abdominal pain (1), diarrhea (1).
  • Nine tumors were proven benign: hamartoma (4), cystic lymphangioma (1), primary amyloid (1), lipoma (1).
  • Seventeen tumors were malignant: five adenocarcinomas, six carcinoids, two melanoma metastases, two gastrointestinal stromal tumors (GIST), one colon carcinoma metastasis, one non-Hodgkin's lymphoma.
  • Tumors were surgically resected in 23 patients.
  • Three of the six with carcinoid tumors have had no recurrence up to 51 months postresection.
  • CONCLUSIONS: Small bowel tumors are a significant finding at CE and are often missed by other methods of investigation.
  • In many patients, detection of a tumor alters management and improves outcome.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / pathology. Intestinal Neoplasms / therapy. Intestine, Small

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  • (PMID = 17032187.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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45. Eyssartier E, Harper L, Michel JL, Rivière JP, Vanderbecken S, De Napoli-Cocci S: Rapidly growing mature retroperitoneal teratomas. J Pediatr Hematol Oncol; 2009 Sep;31(9):705-6
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  • Retroperitoneal mature teratomas are rare benign tumors, most commonly found in neonates and young adults.
  • In both cases, during the delay between diagnosis and surgery, the tumors practically doubled in size every 10 days.
  • We believe the possibility of rapid growth of these tumors implies that treatment should be conducted as soon as possible.
  • [MeSH-major] Infant, Premature, Diseases / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Abdominal Abscess / diagnosis. Cell Division. Diagnostic Errors. Disease Progression. Early Diagnosis. Enterocolitis, Necrotizing / complications. Enterocolitis, Necrotizing / drug therapy. Enterocolitis, Necrotizing / ultrasonography. Female. Humans. Incidental Findings. Infant. Infant, Newborn. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Malnutrition / complications. Nephrectomy. Remission Induction. Tomography, X-Ray Computed. Tumor Burden

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  • (PMID = 19684525.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Bara T, Bancu S, Bara T Jr, Mureşan M, Bancu L, Azamfirei L, Podeanu D, Mureşan S: [Gastric stromal tumor with liver and subcutaneus metastasis. Case report]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):621-4
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  • [Title] [Gastric stromal tumor with liver and subcutaneus metastasis. Case report].
  • The gastrointestinal stromal tumours expand from the undefine mezenchimal cells of the intestinal wall and the origin is in the Cajal interstitial cells.
  • Very importants factors for grading are the tumour localisation, the invasion of serosa or mucosa, the dimensions of tumour and the number of mytosis.
  • We present a case with haemoragic gastric stromal tumour, with small dimensions, which was initially diagnosed as a "benign" tumour.
  • CONCLUSIONS: The gastrointestinals stromal tumours represent a very rare group of digestive tract tumors, with malignant potentially evolution; the first choice of treatment is surgery, with complete ablation of the tumour.
  • [MeSH-major] Gastrointestinal Stromal Tumors / secondary. Liver Neoplasms / secondary. Soft Tissue Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19943565.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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47. Abbasova SG, Vysotskii MM, Ovchinnikova LK, Obusheva MN, Digaeva MA, Britvin TA, Bahoeva KA, Karabekova ZK, Kazantzeva IA, Mamedov UR, Manuchin IB, Davidov MI: Cancer and soluble FAS. Bull Exp Biol Med; 2009 Oct;148(4):638-42
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  • A test system developed by the authors was used to measure serum concentrations of soluble Fas in patients with malignant and benign tumors of different location and morphology.
  • It is proven that the concentrations and incidence of detection of soluble Fas in the sera of patients with tumors are significantly higher than in normal subjects.
  • No appreciable differences in the concentrations of soluble Fas were detected in malignant and benign tumors of the mammary gland, bones, ovaries, and adrenals.
  • In thyroid cancer, soluble Fas levels were higher than in benign and hyperplastic processes in this organ.
  • High level of soluble Fas is associated with late stages of the disease (ovarian cancer, cancer of the corpus uteri, adrenocortical and colorectal cancer) and with poor differentiation of the tumor (ovarian cancer and cancer of the corpus uteri), with local metastases (colorectal and adrenocortical cancer), and with tumor invasion into the myometrial tissue, intestinal wall, and adjacent tissues (cancer of the corpus uteri and colorectal cancer).
  • Soluble Fas levels depended on tumor histogenesis in malignant and benign ovarian tumors.
  • High concentration of soluble Fas was detected in large tumors in patients with ovarian cancer, cancer of the corpus uteri, colorectal cancer, thyroid cancer and adenoma, and in adrenocortical cancer.
  • Initially high levels of soluble Fas are characteristic of patients whose tumors are little sensitive to nonadjuvant radiotherapy.
  • [MeSH-major] Antigens, CD95 / blood. Neoplasms / blood

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  • (PMID = 20396760.001).
  • [ISSN] 1573-8221
  • [Journal-full-title] Bulletin of experimental biology and medicine
  • [ISO-abbreviation] Bull. Exp. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD95
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48. Tascilar O, Cakmak GK, Gün BD, Uçan BH, Balbaloglu H, Cesur A, Emre AU, Comert M, Erdem LO, Aydemir S: Clinical evaluation of submucosal colonic lipomas: decision making. World J Gastroenterol; 2006 Aug 21;12(31):5075-7
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  • Even lipomas are the most common mesenchymal benign tumors of the gastrointestinal tract, symptomatic colonic presentation is rare.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Colonic Neoplasms / therapy. Intestinal Mucosa / pathology. Lipoma / diagnosis. Lipoma / therapy

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  • (PMID = 16937511.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087418
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49. Sudhakar MK, Neeta, Senthil, Ahamed A, John S, Aggarwal G: Gastro-intestinal stromal tumour--a case report. J Indian Med Assoc; 2006 May;104(5):266, 270
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  • [Title] Gastro-intestinal stromal tumour--a case report.
  • Gastro-intestinal stromal tumours are a heterogenous group of mesenchymal tumours mostly arising from the stomach and small intestine which may be benign or malignant.
  • Upper GI scopy showed a proliferative growth in periampullary region with the histopathology of the growth showed features of gastrointestinal stromal tumour.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Abdominal Pain. Adult. Blood Transfusion. Female. Folic Acid / therapeutic use. Humans. Intestinal Mucosa / pathology. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / therapy. Iron / therapeutic use. Tomography, X-Ray Computed / methods

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  • (PMID = 17058574.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 935E97BOY8 / Folic Acid; E1UOL152H7 / Iron
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50. Otomi Y, Otsuka H, Morita N, Terazawa K, Harada M, Nishitani H: A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor. J Med Invest; 2009 Feb;56(1-2):76-9
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  • [Title] A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor.
  • Other subcutaneous masses considered benign and neurogenic in nature also showed FDG uptake (SUVmax around 3 or less), but the degree of FDG uptake differed considerably from the left femoral mass.
  • Incidentally, PET/CT also showed an asymptomatic large abdominal mass with intense FDG uptake (SUVmax 8.8).
  • The abdominal mass was resected and confirmed as gastrointestinal stromal tumor (GIST) of the small intestine.
  • Three months later, the left femoral mass was operated on and pathologically diagnosed as a malignant peripheral nerve sheath tumor (MPNST).
  • We present a rare case of a patient with vRd with a MPNST of the left femur and coincidental GIST of the small intestine.
  • [MeSH-major] Bone Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Intestinal Neoplasms / complications. Nerve Sheath Neoplasms / complications. Osteitis Fibrosa Cystica / complications
  • [MeSH-minor] Femur / radiography. Femur / radionuclide imaging. Fluorodeoxyglucose F18. Humans. Intestine, Small / radiography. Intestine, Small / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19262018.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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51. Hornick JL, Fletcher CD: Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol; 2005 Jul;29(7):859-65
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  • [Title] Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.
  • Benign peripheral nerve sheath tumors are uncommon in the gastrointestinal tract, and perineuriomas have not previously been reported to occur at this anatomic location.
  • In this study, we analyzed the clinicopathologic and immunohistochemical features of 10 perineuriomas arising in the intestine.
  • Eight of the lesions were intramucosal perineuriomas presenting as small sessile polyps detected during colonoscopy; 6 of these 8 patients were asymptomatic and undergoing colorectal cancer screening.
  • The colonic submucosal tumor was microscopically well circumscribed, whereas the jejunal perineurioma showed focal infiltration through the muscularis propria into the subserosa.
  • The stroma was collagenous in the colonic tumor and predominantly myxoid in the jejunal tumor.
  • All tumors except one were positive for epithelial membrane antigen (EMA); 4 of 10 expressed claudin-1 and 2 of 10 expressed CD34.
  • All tumors were negative for S-100 protein, glial fibrillary acidic protein, neurofilament protein, smooth muscle actin, desmin, caldesmon, KIT, and pan-keratin.
  • Electron microscopy was performed on the tumor lacking EMA expression, revealing typical features of perineurioma, namely, spindle cells with long bipolar cytoplasmic processes and prominent pinocytotic vesicles, surrounded by discontinuous basal lamina.
  • No tumor recurred.
  • In summary, perineuriomas may arise in the intestine, most often as intramucosal lesions detected as colorectal polyps with distinctive histologic features including entrapment of colonic crypts.
  • Distinguishing perineuriomas from other spindle cell neoplasms of the gastrointestinal tract can be facilitated by immunostaining for EMA and claudin-1.
  • [MeSH-major] Intestinal Neoplasms / pathology. Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2006 Oct;30(10):1337-9 [17001168.001]
  • (PMID = 15958849.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 26
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52. Murray NR, Weems J, Braun U, Leitges M, Fields AP: Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer Res; 2009 Jan 15;69(2):656-62
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  • Bitransgenic mice overexpressing PKCbetaII and constitutively active PKCiota (PKCbetaII/caPKCiota) or kinase-deficient, dominant-negative PKCiota (PKCbetaII/kdPKCiota) in the colon exhibit a similar increase in colon tumor incidence, tumor size, and tumor burden in response to azoxymethane (AOM) when compared with nontransgenic littermates.
  • However, PKCbetaII/kdPKCiota mice develop predominantly benign colonic adenomas, whereas PKCbetaII/caPKCiota mice develop malignant carcinomas.
  • In contrast, PKCbeta-deficient (PKCbeta(-/-)) mice fail to develop tumors even in the presence of caPKCiota.
  • In contrast, tissue-specific knockout of PKClambda significantly suppresses intestinal tumor formation in Apc(min/+) mice.
  • PKCbetaII is required for AOM-induced tumorigenesis but is dispensable for tumor formation in Apc(Min/+) mice.
  • PKCiota/lambda promotes tumor progression in both AOM- and Apc(min/+)-induced tumorigenesis.
  • Thus, PKCbetaII and PKCiota, whose expression is elevated in both rodent and human colon tumors, collaborate to drive colon tumor formation and progression, respectively.

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  • (PMID = 19147581.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA081436; United States / NCI NIH HHS / CA / CA081436-11; United States / NCI NIH HHS / CA / CA094122; United States / NCI NIH HHS / CA / R01 CA094122; United States / NCI NIH HHS / CA / CA081436; United States / NCI NIH HHS / CA / R01 CA081436-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Isoenzymes; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / Protein Kinase C beta; EC 2.7.11.13 / protein kinase C lambda; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ NIHMS79085; NLM/ PMC2688739
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53. Agaimy A, Bihl MP, Tornillo L, Wünsch PH, Hartmann A, Michal M: Calcifying fibrous tumor of the stomach: clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesis. Am J Surg Pathol; 2010 Feb;34(2):271-8
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  • [Title] Calcifying fibrous tumor of the stomach: clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesis.
  • Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor composed of hyalinized fibrous tissue with interspersed bland fibroblastic spindled cells, scattered psammomatous, and/or dystrophic calcifications and variably prominent mononuclear inflammatory infiltrate.
  • To date, 6 gastric and 3 intestinal CFTs have been reported.
  • Mean tumor size was 2.2 cm.
  • Most tumors originated in the gastric body (6/7).
  • One ulcerated tumor caused iron deficiency anemia and ulcer symptoms.
  • Six tumors involved the muscularis propria with variable submucosal and subserosal extension and 1 arose within thickened muscularis mucosae adjacent to a mucosal invagination.
  • In none of the cases were there remnants of burnt-out GIST, inflammatory fibroid polyp, inflammatory myofibroblastic tumor, leiomyoma, schwannoma, or other specific lesion.
  • All tumors were negative for CD117, S100, smooth muscle actin, desmin, ALK1, h-caldesmon, and PDGFRA.
  • All 5 tumors with available tissue for molecular analysis were wild-type for KIT and PDGFRA.
  • [MeSH-major] Calcinosis / pathology. Neoplasms, Fibrous Tissue / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. DNA Mutational Analysis. Female. Humans. Incidental Findings. Male. Middle Aged

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  • (PMID = 20090503.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Mathieu N: [Risk of long-term treatment with proton pump inhibitors]. Rev Prat; 2008 Sep 15;58(13):1451-4
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  • Gastric endocrine cell hyperplasia can occur in 10 to 30% of patients without carcinoid tumors.
  • Proton pump inhibitor-associated gastric polyps are totally benign tumors that should not be followed.
  • PPIs do not inhibit intestinal absorption of lipids, iron, phosphorus, magnesium or zinc from food but can affect vitamin B12 status in older patients.
  • [MeSH-minor] Bacterial Infections / chemically induced. Colonic Neoplasms / chemically induced. Gastric Acid / secretion. Gastrins / blood. Gastrins / drug effects. Humans. Polyps / chemically induced. Vitamin B 12 Deficiency / chemically induced

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  • (PMID = 18924330.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Gastrins; 0 / Proton Pump Inhibitors
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55. Yimyaem P, Saranrittichai S, Sinawat P, Dhiensiri T: Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant. J Med Assoc Thai; 2009 Jan;92(1):114-9
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  • [Title] Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant.
  • Benign intestinal tumors are rare in children; however, the authors describe an inflammatory myofibroblastic tumor (IMT) of the terminal ileum in a 2-month-old infant who presented with an intestinal obstruction.
  • A review of the literature for this rare condition was done to delineate the natural history of this tumor and to do a histological confirmation of its benign nature.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Ileal Diseases / pathology. Intestinal Obstruction / pathology


56. Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M: Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol; 2005 Sep 7;11(33):5226-8
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  • [Title] Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report.
  • Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract.
  • Although rare, it is the most common primary tumor of the mesentery and can develop at any age.
  • We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST).
  • This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall.
  • Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor STI571 (imatinib mesylate) has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 16127758.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320401
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57. Coco C, Rizzo G, Manno A, Mattana C, Verbo A: Surgical treatment of small bowel neoplasms. Eur Rev Med Pharmacol Sci; 2010 Apr;14(4):327-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of small bowel neoplasms.
  • Small intestinal neoplasms are uncommon cancers.
  • Benign small intestinal tumors (e.g., leiomyoma, lipoma, hamartoma, or desmoid tumor) usually are asymptomatic but may present with complications.
  • Primary malignancies of the small intestine, including adenocarcinoma, leiomyosarcoma, carcinoid, and lymphoma, are often symptomatic and may present with intestinal obstruction, jaundice, bleeding, or pain.
  • Metastatic neoplasms may involve the small intestine via contiguous spread, peritoneal metastases or hematogenous metastases.
  • Because the small intestine is relatively inaccessible to routine endoscopy, diagnosis of small intestinal neoplasms is often delayed for months after onset of symptoms.
  • During last years the increase of small bowel endoscopy and other diagnostic tools allow earlier non-operative diagnosis.
  • Even though radical resection of small bowel cancer plays an important role, the 5 yr overall survival remains low.
  • [MeSH-major] Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery. Humans. Laparoscopy. Lymphoma / pathology. Lymphoma / surgery. Neoplasm Metastasis

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  • (PMID = 20496543.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 51
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58. Kimchi NA, Eliakim R, Suissa A, Scapa E: [The contribution of capsule endoscopy to the diagnosis of small-bowel tumors in cases of obscure overt gastrointestinal bleeding]. Harefuah; 2006 Nov;145(11):811-4, 862, 861
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The contribution of capsule endoscopy to the diagnosis of small-bowel tumors in cases of obscure overt gastrointestinal bleeding].
  • BACKGROUND: The source of obscure bleeding is usually located in the small bowel.
  • GOALS: To review our experience with the diagnosis of small bowel tumors by CE in patients with obscure overt gastrointestinal bleeding.
  • RESULTS: Among 156 patients who underwent CE examination (including 58 patients with obscure overt bleeding), five patients, all of whom presented with melena, were diagnosed as having a small bowel tumor.
  • Three tumors were found in one patient (two ileal carcinoids and one ileal benign stromal tumor).
  • A jejunal benign stromal tumor was diagnosed in two other patients by push enteroscopy.
  • In two patients, three small tumors were detected, beyond the reach of push enteroscopy, but surgical confirmation was not available.
  • No tumors were found among patients in whom the indication for CE examination was not obscure overt bleeding.
  • CONCLUSIONS: The possibility of finding a small bowel tumor emphasizes the role of capsule endoscopy in patients with obscure overt gastrointestinal bleeding.
  • [MeSH-major] Capsule Endoscopy / methods. Gastrointestinal Hemorrhage / etiology. Intestinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Humans. Jejunal Neoplasms / diagnosis. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17183952.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Israel
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59. Gao Y, Zhang B: [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality]. Ai Zheng; 2009 Dec;28(12):1277-82
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  • [Title] [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality].
  • BACKGROUND AND OBJECTIVE: Telomerase transcriptional elements-interacting factor (TEIF) gene found recently by our research group is a transcription factor of a kind of human telomerase reverse transcriptase (hTERT) gene, and expresses in many kinds of tumor tissues.
  • This study was to evaluate the expression of TEIF protein in human colorectal tumors and to explore its correlation with centrosome abnormality.
  • METHODS: The expression of TEIF in 10 specimens of normal intestinal mucosa tissue, 30 specimens of colorectal cancer, and 54 specimens of colorectal adenoma was detected by immunohistochemistry.
  • RESULTS: Immunohistochemistry results showed that the differences of TEIF protein expression between the normal group and each tumor groups were statistically significant (P<0.01), and the difference of TEIF protein expression between the malignant tumor group and the benign group was not significant (P>0.05).
  • CONCLUSIONS: TEIF protein and centrosome amplification is commonly found in colorectal tumors.
  • The expression level of TEIF is related to tumor histological grade and malignant degree.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Centrosome / pathology. Colorectal Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Male. Middle Aged. Tubulin / metabolism

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  • (PMID = 19958622.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Transcription Factors; 0 / Tubulin; EC 2.7.1.- / SCYL1 protein, human
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60. Merchant NB, Parikh AA, Kooby DA: Should all distal pancreatectomies be performed laparoscopically? Adv Surg; 2009;43:283-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There are both enough experience and data (though retrospective) to confirm that LDP with or without spleen preservation appears to be a safe treatment for benign or noninvasive lesions of the pancreas.
  • Based on the fact that LDP can be performed with similar or shorter operative times, blood loss, complication rates, and length of hospital stay than ODP, it can be recommended as the treatment of choice for benign and noninvasive lesions in experienced hands when clinically indicated.
  • It is very difficult to make clear recommendations with regard to laparoscopic resection of malignant pancreatic tumors due to the lack of conclusive data.
  • Additional areas of discovery are in staple line reinforcement for left pancreatectomy and suturing technology for pancreatico-intestinal anastomosis.
  • Can we enucleate a small tumor off the pancreatic body by passing an endoscope through the gastric (or colonic) wall, and bring the specimen out via the mouth or anus?

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  • (PMID = 19845186.001).
  • [ISSN] 0065-3411
  • [Journal-full-title] Advances in surgery
  • [ISO-abbreviation] Adv Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 95
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61. Chiesa AG, Deavers MT, Veras E, Silva EG, Gershenson D, Malpica A: Ovarian intestinal type mucinous borderline tumors: are we ready for a nomenclature change? Int J Gynecol Pathol; 2010 Mar;29(2):108-12
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  • [Title] Ovarian intestinal type mucinous borderline tumors: are we ready for a nomenclature change?
  • At a National Cancer Institute-sponsored workshop it was proposed that the borderline category of ovarian intestinal-type mucinous tumors (OInMTs) could be eliminated if the apparent benign behavior of these tumors could be confirmed.
  • Optimal sampling and adequate sampling were defined as at least 1 section per centimeter of maximum tumor dimension and at least 1 section per 2 cm of maximum tumor dimension, respectively.
  • Tumor size ranged from 8 to 39 cm (mean 20 cm).
  • The sampling of the ovarian tumor was optimal in 28 cases and adequate in 5 cases.
  • The tumor was incompletely removed and recurred in the pelvis 1 year later.
  • Ten months later, the tumor re-recurred in the pelvis and could only be drained because of the patient's advanced age and her poor medical status.
  • The second patient with recurrent tumor had undergone a cystectomy and full staging for a borderline OInMT.
  • However, borderline OInMTs are usually large and heterogeneous, and the standard sampling protocol for them is not evidence based.
  • [MeSH-major] Adenocarcinoma, Mucinous / classification. Adenocarcinoma, Mucinous / pathology. Ovarian Neoplasms / classification. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Histocytochemistry. Humans. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Retrospective Studies. Terminology as Topic. Young Adult

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  • [CommentIn] Int J Gynecol Pathol. 2010 Nov;29(6):552-3; author reply 553-4 [20881857.001]
  • (PMID = 20173495.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. de Herder WW, Kwekkeboom DJ, Valkema R, Feelders RA, van Aken MO, Lamberts SW, van der Lely AJ, Krenning EP: Neuroendocrine tumors and somatostatin: imaging techniques. J Endocrinol Invest; 2005;28(11 Suppl International):132-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendocrine tumors and somatostatin: imaging techniques.
  • Tumors and metastases bearing the somatostatin receptor subtypes 2 (SSTR2) or SSTR5 can be visualized in vivo after injection of radiolabeled octapeptide somatostatin analogs like 111In-pentetreotide.
  • The sensitivity of 111In-pentetreotide scintigraphy for the detection of carcinoid tumors is 86-95%.
  • The sensitivity of 111In-pentetreotide scintigraphy for the detection of gastrinomas, vasoactive intestinal polypeptide-secreting tumors, and glucagonomas as well as clinically non-functioning lesions is 75-100%.
  • 111In-pentetreotide scintigraphy generally has a lower detection rate for benign pheochromocytomas than 123I-MIBG scintigraphy, but it can have a complementary role for the staging of malignant pheochromocytomas.
  • 111In-pentetreotide scintigraphy has been successful for the localization of extra-pituitary ACTH-secreting tumors and their metastases, and especially for occult tumors.
  • A large variety of lesions in and around the pituitary region express somatostatin receptors and, therefore, can be visualized by 111In-pentetreotide scintigraphy.
  • [MeSH-major] Neuroendocrine Tumors / radionuclide imaging. Somatostatin
  • [MeSH-minor] Carcinoid Tumor / radionuclide imaging. Gastrointestinal Neoplasms / radionuclide imaging. Humans. Indium Radioisotopes. Paraganglioma / radionuclide imaging. Pheochromocytoma / radionuclide imaging. Pituitary Neoplasms / radionuclide imaging. Receptors, Somatostatin / analysis

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  • (PMID = 16625862.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Indium Radioisotopes; 0 / Receptors, Somatostatin; 0 / somatostatin receptor 2; 0 / somatostatin receptor 5; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide
  • [Number-of-references] 49
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63. Suárez Moreno RM, Hernández Ramírez DA, Madrazo Navarro M, Salazar Lozano CR, Martínez Gen R: Multiple intestinal lipomatosis. Case report. Cir Cir; 2010 Mar-Apr;78(2):163-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple intestinal lipomatosis. Case report.
  • BACKGROUND: Intestinal lipomatosis is a rare disease with an incidence at autopsy ranging from 0.04 to 4.5%.
  • Intestinal barium studies, ultrasonography and computed tomography (CT) are useful diagnostic techniques.
  • Abdominal CT with contrast enhancement demonstrated multiple submucosal masses in stomach and small bowel.
  • No specific treatment, invasive procedures or surgery were performed for the asymptomatic intestinal lipomas.
  • CONCLUSIONS: Benign tumors of the small bowel are relatively rare, with lipoma being the most common type.
  • [MeSH-major] Intestinal Diseases / diagnosis. Intestine, Small. Lipomatosis / diagnosis

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  • (PMID = 20478119.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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64. McKenney JK, Soslow RA, Longacre TA: Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol; 2008 May;32(5):645-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei.
  • Mucinous epithelial neoplasms arising in association with mature teratomas are a heterogeneous group of tumors, but with the exception of a single recent study, their full histologic spectrum, detailed immunophenotype, and association with classic pseudomyxoma peritonei (PMP) have not been fully studied.
  • The morphologic, immunohistochemical, and clinical features of 42 patients with mucinous epithelial tumors arising in association with mature ovarian teratomas were evaluated.
  • Tumor size ranged from 5.5 to greater than 200 cm.
  • Most teratoma-associated mucinous tumors were unilateral, although 1 patient harbored bilateral mucinous tumors in association with bilateral teratomas.
  • Using the 2003 World Health Organization criteria for ovarian intestinal type mucinous neoplasms, 17 (40%) were classified as mucinous cystadenoma, 16 (38%) as intestinal-type mucinous epithelial neoplasm of low malignant potential (IM-LMP), 4 (10%) as intraepithelial carcinoma (IEC), and 5 (12%) as invasive mucinous carcinoma.
  • We report that a significant proportion of mucinous tumors associated with mature ovarian teratomas present with clinical PMP, which in most cases is associated with IM-LMP.
  • Pseudomyxoma ovarii is common in this setting, particularly in tumors with IM-LMP histology, but pseudomyxoma ovarii is not predictive of PMP.
  • Ovarian teratoma-associated benign and IM-LMP mucinous neoplasms with microscopic peritoneal low-grade mucinous epithelium do not seem to be at significant risk for intra-abdominal recurrence, but numbers are few and follow-up is limited.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology. Teratoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged. Mucins / metabolism. Neoplasms, Multiple Primary


65. Ferrarese F, Cecere V: [Gastro-intestinal stromal tumours (GISTs): prognostic and therapeutic features]. G Chir; 2006 May;27(5):205-8
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  • [Title] [Gastro-intestinal stromal tumours (GISTs): prognostic and therapeutic features].
  • The biological behaviour is only hypothetical, according to the duration of symptomatology, the site and size of the tumour, the presence of hemorrhagic or necrotic areas, the cytological modifications and, above all, the number of mytosis: 5 mytosis x 50 HPF are considered significant for malignancy.
  • In the benign GISTs (26 pts) we have reported early mortality only in 5 cases; in the borderline forms (6 pts), in 4 rapidly evolving cases, the tumour had > 5 cm in size and the mytosis were > 5 x 50 HPF.
  • [MeSH-major] Gastrointestinal Stromal Tumors

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  • (PMID = 16857107.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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66. Levin TG, Powell AE, Davies PS, Silk AD, Dismuke AD, Anderson EC, Swain JR, Wong MH: Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology; 2010 Dec;139(6):2072-2082.e5
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  • [Title] Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract.
  • BACKGROUND & AIMS: CD166 (also called activated leukocyte cell adhesion molecule [ALCAM]) is a marker of colorectal cancer (CRC) stem cells; it is expressed by aggressive tumors.
  • Although the presence of CD166 at the tumor cell surface has been correlated with shortened survival, little is known about its function and expression in normal intestinal epithelia.
  • METHODS: We characterized the expression pattern of CD166 in normal intestinal tissue samples from humans and mice using immunohistochemisty, flow cytometry, and quantitative reverse-transcriptase polymerase chain reaction.
  • Human and mouse intestinal tumors were also analyzed.
  • RESULTS: CD166 was expressed on the surface of epithelial cells within the stem cell niche and along the length of the intestine; expression was conserved across species.
  • In the small intestine, CD166 was observed on crypt-based Paneth cells and intervening crypt-based columnar cells (putative stem cells).
  • CD166 was located in the cytoplasm and at the surface of cells within human CRC tumors.
  • CD166-positive cells were also detected in benign adenomas in mice; rare cells coexpressed CD166 and CD44 or epithelial-specific antigen.
  • CONCLUSIONS: CD166 is highly expressed within the endogenous intestinal stem cell niche.
  • CD166-positive cells appear at multiple stages of intestinal carcinoma progression, including benign and metastatic tumors.
  • Further studies should investigate the function of CD166 in stem cells and the stem cell niche, which might have implications for normal intestinal homeostasis.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20826154.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA118235; United States / NIDDK NIH HHS / DK / U01 DK085525-02; United States / NHLBI NIH HHS / HL / T32 HL007781; United States / NCI NIH HHS / CA / CA106195-06A1; United States / NCI NIH HHS / CA / CA118235-05; United States / NICHD NIH HHS / HD / T32 HD049309-05; United States / NCI NIH HHS / CA / CA106195; United States / NCI NIH HHS / CA / T32 CA106195; United States / NICHD NIH HHS / HD / HD049309; United States / NICHD NIH HHS / HD / T32 HD049309; United States / NCI NIH HHS / CA / T32 CA106195-06A1; United States / NHLBI NIH HHS / HL / T32 HL007781-14; United States / NIDDK NIH HHS / DK / R01 DK068326; United States / NCI NIH HHS / CA / CA118235; United States / NIDDK NIH HHS / DK / R01 DK068326-05; United States / NIDDK NIH HHS / DK / DK068326; United States / NIDDK NIH HHS / DK / DK085525-02; United States / NICHD NIH HHS / HD / HD049309-05; United States / NHLBI NIH HHS / HL / HL007781-14; United States / NHLBI NIH HHS / HL / HL007781; United States / NIDDK NIH HHS / DK / U01 DK085525; United States / NIDDK NIH HHS / DK / DK085525; United States / NIDDK NIH HHS / DK / DK068326-05; United States / NCI NIH HHS / CA / R01 CA118235-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALCAM protein, human; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules, Neuronal; 0 / Fetal Proteins
  • [Other-IDs] NLM/ NIHMS234467; NLM/ PMC2997177
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67. Zang L, Hu WG, Yan XW, Zhang T, Ma JJ, Ye Q, Feng B, Wang ML, Lu AG, Li JW, Zhong J, Zheng MH: Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A; 2010 Jul-Aug;20(6):521-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment for small intestinal bleeding: a report of 77 cases.
  • BACKGROUND: Morbidity of small intestinal disease is rare and the associated lesion is hard to be detected due to lack of specific manifestations and effective diagnostic approaches.
  • Hematochezia and melena are the most common symptoms in small intestinal diseases.
  • Hence, small intestinal disease is an important differential diagnosis when hematochezia or melena occurs, especially when gastric and colonic diseases are excluded.
  • As the small intestinal lesion is hard to be located preoperatively, laparotomy used to be performed without a preoperative location.
  • With the development of laparoscopic technique, laparoscopic operations are more frequently applied to surgical disease, despite their benign or malignant nature.
  • Generally, almost all kinds of small intestinal disease can be treated with laparoscopic surgery.
  • METHODS: Clinical data of 77 patients with small intestinal bleeding undergoing laparoscopic or laparoscopy-assisted operations from April 2003 to December 2008 were included, and their clinical information were analyzed retrospectively.
  • There was 1 case of gastrointestinal stromal tumor with local recurrence and hepatic metastasis.
  • Four patients died from metastasis of malignant tumors during the follow-up from 2 to 70 months after operations.
  • CONCLUSIONS: Laparoscopic treatment in small intestinal bleeding is feasible, safe, and minimally invasive.
  • It may be widely used in the future for its good therapeutic outcomes and improved diagnostic chance in small intestinal bleeding diseases.
  • [MeSH-major] Gastrointestinal Hemorrhage / surgery. Intestine, Small. Laparoscopy
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Loss, Surgical. Female. Humans. Intestinal Neoplasms / diagnosis. Length of Stay. Male. Melena / diagnosis. Middle Aged. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):771 [20874417.001]
  • (PMID = 20687815.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Baichi MM, Arifuddin RM, Mantry PS: Small-bowel masses found and missed on capsule endoscopy for obscure bleeding. Scand J Gastroenterol; 2007 Sep;42(9):1127-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small-bowel masses found and missed on capsule endoscopy for obscure bleeding.
  • OBJECTIVE: Data on the nature of small-bowel tumors found or missed by capsule endoscopy (CE) are limited.
  • The aim of this study was to review the CE findings in patients with small-bowel tumors presenting as obscure gastrointestinal (GI) bleeding.
  • RESULTS: Ten (3%) confirmed small-bowel masses were found in 9 patients.
  • Most (80%) of the lesions were potentially malignant: adenocarcinoma (n=4), neuroendocrine carcinoma (n=1), leiomyosarcoma (n=1), and GI stroma cell tumors (GISTs) (n=2).
  • Benign lesions included inflammatory fibroid polyp (n=1) and lipoma (n=1).
  • CE findings led directly to tumor diagnosis in 7 of the 10 cases.
  • CONCLUSIONS: Small-bowel tumors are a rare but serious source of obscure GI bleeding.
  • Our large single-center experience shows that most lesions are of malignant potential.
  • Tumors can have an atypical appearance including focal ulceration, nodularity, or active bleeding without a clear lesion.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Gastrointestinal Hemorrhage / etiology. Humans. Intestine, Small. Male. Middle Aged. Retrospective Studies. Treatment Outcome


69. Kara C, Kutlu AO, Tosun MS, Apaydin S, Senel F: Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. Horm Res; 2005;63(5):252-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by benign intestinal hamartomatous polyps and mucocutaneous pigmentation, and with an increased risk for intestinal and extra-intestinal neoplasms.
  • Sertoli cell tumors in boys with PJS have been increasingly recognized as a cause of prepubertal gynecomastia.
  • We report on a 7.25-year-old boy with PJS, bilateral gynecomastia, Sertoli cell tumor and nephrocalcinosis, and present the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • Histopathological examination was consistent with Sertoli cell tumors.
  • [MeSH-major] Aromatase Inhibitors / therapeutic use. Gynecomastia / complications. Peutz-Jeghers Syndrome / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testolactone / therapeutic use

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  • (PMID = 15947469.001).
  • [ISSN] 0301-0163
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 6J9BLA949Q / Testolactone
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70. Nagaraj PB, Ongole R, Bhujanga-Rao BR: Granular cell tumor of the tongue in a 6-year-old girl--a case report. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E162-4
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  • [Title] Granular cell tumor of the tongue in a 6-year-old girl--a case report.
  • Granular cell tumor is a relatively uncommon benign hamartomatous lesion occurring in almost any part of the body.
  • Granular cell lesions may be found in other diverse sites such as the jaw, skin, gastro intestinal tract and respiratory tract.
  • The tumor generally occurs in middle or older aged adults.
  • As most of the granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • We describe a case of granular cell tumor of the tongue in a 6 year old girl along with a brief review of literature on granular cell tumors.
  • [MeSH-major] Granular Cell Tumor. Tongue Neoplasms

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  • (PMID = 16505796.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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71. Mehrabi A, Mood ZA, Roshanaei N, Fonouni H, Müller SA, Schmied BM, Hinz U, Weitz J, Büchler MW, Schmidt J: Mesohepatectomy as an option for the treatment of central liver tumors. J Am Coll Surg; 2008 Oct;207(4):499-509
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  • [Title] Mesohepatectomy as an option for the treatment of central liver tumors.
  • BACKGROUND: Despite substantial improvements in intra- and postoperative management of extended hemihepatectomy as the curative option for treatment of central liver tumors, the high morbidity and mortality rates accompanying the procedure still represent major obstacles.
  • STUDY DESIGN: Forty-eight consecutive patients (29 men and 19 women) with centrally located liver tumors underwent mesohepatectomy.
  • Indications for mesohepatectomy were liver metastasis (n = 29), hepatocellular carcinoma (n = 5), gallbladder carcinoma (n = 4), cholangiocellular carcinoma (n = 4), hemangioma (n = 2), and other benign diseases (n = 4).
  • Postoperative surgical complications were seen in 18.8% of patients (n = 9) and included liver failure (n = 1), intraabdominal abscess (n = 1), bilioma or bile leakage (n = 4), hemorrhage and hematoma (n = 2), peritonitis because of intestinal perforation (n = 1), and wound infection (n = 1).
  • Although it is a technically difficult operation and requires special attention to prevent surgical complications, it is justified in selected patients with centrally located tumors and is a feasible and safe alternative to extended liver resection.
  • [MeSH-major] Hepatectomy. Liver Neoplasms / surgery

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  • [ErratumIn] J Am Coll Surg. 2010 Jun;210(6):1022. Mood, Zhoobin [corrected to Mood, Zhoobin A]
  • (PMID = 18926451.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Emanuel P, Qin L, Harpaz N: Calcifying fibrous tumor of small intestine. Ann Diagn Pathol; 2008 Apr;12(2):138-41
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  • [Title] Calcifying fibrous tumor of small intestine.
  • Calcifying fibrous tumor (CFT) is a rare benign tumor with a predilection for children and young adults that usually arises in the subcutaneous and deep soft tissues, pleura, or peritoneum.
  • Calcifying fibrous tumor of the gastrointestinal tract is exceedingly rare and therefore prone to confusion with other spindle cell lesions more commonly encountered in this location.
  • We describe 4 cases of calcifying fibrous tumor arising in the terminal ileum, one of which caused the heretofore unreported complication of intestinal intussusception, and discuss the differential diagnosis with other common and uncommon spindle cell lesions.
  • [MeSH-major] Calcinosis / pathology. Fibroma / pathology. Ileal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibromatosis, Aggressive / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Humans. Male

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  • (PMID = 18325476.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Nishihara E, Miyauchi A, Hirokawa M, Kudo T, Ohye H, Ito M, Kubota S, Fukata S, Amino N, Kuma K: Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature. Endocrine; 2006 Oct;30(2):231-6
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  • [Title] Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature.
  • Benign thyroid teratomas are rare in adolescents and adults.
  • We report on three cases of benign thyroid teratomas that presented as painful tumors in the neck after puberty.
  • The tumor adjacent to the thyroid in each case showed rapid enlargement with predominant cystic lesions within several months.
  • Ultrasonography and computed tomography revealed few findings suggesting the origin of the tumor.
  • Cytological examination and culture of the aspirate failed to show cells originating from the thyroid or infectious findings, but revealed a small population of columnar epithelial cells or squamous epithelial cells.
  • The patients subsequently underwent resection of the tumor, and microscopic examination revealed various types of tissue including pancreas, adipose, cartilage, muscle, and skin, and the cystic wall was lined by gastric, intestinal, respiratory, and stratified squamous epithelium.
  • Surgical resection was curative, and subsequent histologic examination revealed mature benign teratomas of the thyroid.
  • The main characteristic of our cases presented the painful tumors due to the enlarged cystic formation lined by a variety of different types of epithelium, which agreed with previous cases of benign thyroid teratomas in adolescents and adults.
  • [MeSH-major] Pain / diagnosis. Teratoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasms / diagnosis

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  • (PMID = 17322585.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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74. Kelly RJ, Barrett C, Swan N, McDermott R: Metastatic phyllodes tumor causing small-bowel obstruction. Clin Breast Cancer; 2009 Aug;9(3):193-5
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  • [Title] Metastatic phyllodes tumor causing small-bowel obstruction.
  • Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas.
  • Metastases to the small intestine are extremely rare, with only 1 case of metastatic spread to the duodenum reported in the literature.
  • This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction.
  • Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems.
  • The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Ileal Neoplasms / secondary. Intestinal Obstruction / etiology. Phyllodes Tumor / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19661046.001).
  • [ISSN] 1938-0666
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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75. Chen TH, Lin CJ, Wu RC, Ho YP, Hsu CM, Lin WP, Tseng YP, Chen CH, Chiu CT: The application of miniprobe ultrasonography in the diagnosis of colorectal subepithelial lesions. Chang Gung Med J; 2010 Jul-Aug;33(4):380-8
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  • Thirteen patients, suspected of having rectal carcinoid tumors (mean size, 6.9 +/- 3.3 mm), were treated radically by endoscopic mucosal resection using a transparent cap (EMRC) after EUS confirmation of no muscular invasion.
  • Three patients had no residual or recurrent carcinoid tumor on EUS examination after previous empiric polypectomy or biopsy.
  • Five patients had suspected rectal myogenic stromal tumors on EUS; three were transferred for surgical resection due to uterine myoma compression (N = 2) or mucinous adenocarcinoma of the appendix with rectal metastasis (N = 1), and two had uterine myoma detected by gynecologic ultrasound or CT.
  • One appendiceal stone with orifice obstruction mimicking cecal submucosal tumor was proved by surgical resection.
  • The other six patients had various benign lesions, which were diagnosed and followed-up by EUS without progression.
  • [MeSH-major] Colonoscopy / methods. Colorectal Neoplasms / ultrasonography. Endosonography / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Intestinal Mucosa / pathology. Male. Middle Aged

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  • (PMID = 20804667.001).
  • [ISSN] 2309-835X
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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76. Uenoyama Y, Seno H, Fukuda A, Sekikawa A, Nanakin A, Sawabu T, Kawada M, Kanda N, Suzuki K, Yada N, Fukui H, Chiba T: Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway. Oncogene; 2006 Jun 1;25(23):3277-85
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  • [Title] Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway.
  • Cyclooxygenase-2 (COX-2) plays important roles in tumor development.
  • Especially in the early-stage colorectal tumors, COX-2 expression is often observed in the tumor stroma.
  • In the present study, we simulated the indirect interaction between epithelial cells and stromal cells in the process of colorectal tumor development using an in vitro co-culture model in which NIH3T3 fibroblasts were co-cultured with 'sparsely' or 'densely' populated intestinal epithelial cells, Intestine-407 as a model of premalignant or benign intestinal epithelial cells, and DLD-1 and Caco-2 as models of malignant epithelial cells.
  • Interestingly, there was pericellular hypoxia in the vicinity of NIH3T3 fibroblasts when co-cultured with 'dense' epithelial cells, and the recovery of the partial pressure of oxygen level resulted in the reduction of enhanced COX-2 expression only in NIH3T3 fibroblasts co-cultured with 'dense' Intestine-407 cells.
  • Thus, pericellular hypoxia of the stromal cells caused by densely populated epithelial cells may be one of the potent COX-2 enhancers before completion of malignant transformation during intestinal tumor development.
  • [MeSH-major] Anoxia / enzymology. Cyclooxygenase 2 / biosynthesis. Intestinal Mucosa / cytology. Intestinal Mucosa / enzymology. Membrane Proteins / biosynthesis. Signal Transduction / physiology. Transcription Factor AP-1 / physiology
  • [MeSH-minor] Animals. Caco-2 Cells. Cell Count. Cell Line, Tumor. Coculture Techniques. Enzyme Induction / physiology. Humans. Mice. NIH 3T3 Cells. Precancerous Conditions / enzymology. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Stromal Cells / enzymology. Stromal Cells / pathology

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  • (PMID = 16407821.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Transcription Factor AP-1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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77. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • [Title] A shift in the diagnostics of the small intestine tumors.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • METHODOLOGY: A retrospective study comprising 96 patients having undergone surgery for a small intestine tumor in our hospital from 1996 to 2005 is presented.
  • In the year 1998 we changed our philosophy in trying to directly detect the small intestine pathology and not making the diagnosis by the exclusion only.
  • Intestinal ultrasound was performed on the Ultramark 3000 HDI device with autofocussable convex 5 MHz and linear 7.5 MHz probes or nowadays ATL 5000 HDI, 7-12 MHz linear probe.
  • RESULTS: We treated surgically 96 patients with the small intestine tumor.
  • CONCLUSION: The small bowel ultrasound can be recommended as the first choice method.
  • All patients with even very moderate abdominal symptoms ought to be examined for the small intestine pathology.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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78. Kilicoglu B, Kismet K, Gollu A, Sabuncuoglu MZ, Akkus MA, Serin-Kilicoglu S, Ustun H: Case report: mesenteric schwannoma. Adv Ther; 2006 Sep-Oct;23(5):696-700
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  • Schwannomas are benign neurogenic tumors that arise from Schwann cells that line the sheaths of peripheral nerves.
  • The mass was completely excised and included a 4-cm-long intestinal segment that was densely adherent to the mass.
  • Although schwannomas are very rare and generally asymptomatic, these tumors can become quite large and may cause acute abdominal problems such as mechanical bowel obstruction.
  • [MeSH-major] Mesentery. Neurilemmoma / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Humans. Intestinal Obstruction / etiology. Male. Middle Aged

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  • (PMID = 17142203.001).
  • [ISSN] 0741-238X
  • [Journal-full-title] Advances in therapy
  • [ISO-abbreviation] Adv Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Kim SG: [Incidental gastrointestinal subepithelial mass]. Korean J Gastroenterol; 2010 Dec;56(6):341-5
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  • Most of gastrointestinal subepithelial mass are small-sized and asymptomatic tumor with benign nature, but gastrointestinal stromal tumor should be ruled-out because of its malignant behavior.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / diagnostic imaging. Intestinal Neoplasms / pathology. Stomach Neoplasms / diagnosis. Stomach Neoplasms / diagnostic imaging. Stomach Neoplasms / pathology. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 21173556.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
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80. Biermann K, Heukamp LC, Büttner R, Zhou H: Uterine tumor resembling an ovarian sex cord tumor associated with metastasis. Int J Gynecol Pathol; 2008 Jan;27(1):58-60
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  • [Title] Uterine tumor resembling an ovarian sex cord tumor associated with metastasis.
  • Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are very rare, usually benign uterine tumors, and are probably derived from uterine mesenchymal stem cells.
  • Four years after a diagnosis of UTROSCT of the uterine corpus, the patient developed obstructive ileus due to a large infiltrating tumor within the small bowel with the same morphology and expression pattern as the previously diagnosed UTROSCT.
  • In addition, 2 benign gastrointestinal stromal tumors were detected in the same patient.
  • This case indicates that although the majority of UTROSCT are benign tumors, some of them might undergo malignant transformation and have a metastatic potency.
  • [MeSH-major] Intestinal Neoplasms / secondary. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology. Humans. Immunohistochemistry. Intestinal Obstruction / etiology. Intestine, Small / metabolism. Intestine, Small / pathology. Neoplasms, Second Primary / metabolism. Neoplasms, Second Primary / pathology

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  • (PMID = 18156976.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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81. Chiang JM, Lin YS: Tumor spectrum of adult intussusception. J Surg Oncol; 2008 Nov 1;98(6):444-7
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  • [Title] Tumor spectrum of adult intussusception.
  • PATIENTS AND METHODS: Patients older than 16 years and diagnosed with intestinal intussusception between January 1990 and June 2006 were retrospectively reviewed.
  • RESULTS: Seventy-two patients underwent surgery for intestinal intussusception.
  • Neoplasm was identified as the cause of intussusception in 66 (92%) cases, and 6 (8%) were idiopathic.
  • Lipoma (15 of 40 patients, 38%) and Peutz-Jegher adenoma (10 of 40 patients, 25%) were the two most common lesions of benign small bowel neoplasms while 27% (3 of 11) of malignant enteric intussusception cases were malignant lymphoma and metastatic respectively.
  • CONCLUSION: Lipoma is the most common benign tumor in both small and large bowel intussusception.
  • Whereas 80% of tumors associated with small bowel intussusception were benign, two-thirds of colonic intussusceptions had resulted from primary adenocarcinoma.
  • [MeSH-major] Intestinal Diseases / etiology. Intestinal Neoplasms / complications. Intussusception / etiology
  • [MeSH-minor] Abdominal Pain / etiology. Adenocarcinoma / complications. Adenoma / complications. Adolescent. Adult. Aged. Aged, 80 and over. Cystadenocarcinoma, Mucinous / complications. Female. Humans. Lipoma / complications. Lymphoma, Large B-Cell, Diffuse / complications. Male. Middle Aged. Peutz-Jeghers Syndrome / complications. Retrospective Studies

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • [ErratumIn] J Surg Oncol. 2009 Jun 1;99(7):457
  • (PMID = 18668640.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Olesen SH, Christensen LL, Sørensen FB, Cabezón T, Laurberg S, Orntoft TF, Birkenkamp-Demtröder K: Human FK506 binding protein 65 is associated with colorectal cancer. Mol Cell Proteomics; 2005 Apr;4(4):534-44
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  • In a previously published microarray study an EST (W80763), later identified as the gene hFKBP10 (NM_021939), was found to be strongly expressed in tumors while absent in the normal mucosa.
  • Analysis of 31 colorectal adenocarcinomas and 14 normal colorectal mucosa by RealTime PCR for hFKBP10 showed a significant up-regulation in tumors, when compared with normal mucosa.
  • Immunohistochemical analysis of 26 adenocarcinomas and matching normal mucosa, as well as benign hyperplastic polyps and adenomas, using a monoclonal anti-hFKBP65 antibody, showed that the protein was not present in normal colorectal epithelial cells, but strongly expressed in the tumor cells of colorectal cancer.
  • The protein was also expressed in fibroblasts of both normal mucosa and tumor tissue.
  • Western blot analysis of matched tumors and normal mucosa supported the finding of increased hFKBP65 expression in tumors compared with normal mucosa, in addition to identifying the molecular mass of hFKBP65 to approximately 72 kDa.
  • [MeSH-major] Adenocarcinoma / metabolism. Colorectal Neoplasms / metabolism. Tacrolimus Binding Proteins / metabolism
  • [MeSH-minor] Adenoma / pathology. Aged. Aged, 80 and over. Amino Acid Sequence. Animals. Antibodies, Monoclonal / metabolism. Binding Sites. Blotting, Western. COS Cells. Cercopithecus aethiops. Colonic Polyps / pathology. Electrophoresis, Gel, Two-Dimensional. Electrophoresis, Polyacrylamide Gel. Female. Gene Expression Regulation, Neoplastic. Humans. Hyperplasia. Immunohistochemistry. Intestinal Mucosa / cytology. Isoelectric Point. Male. Microscopy, Fluorescence. Middle Aged. Molecular Sequence Data. Molecular Weight. Polymerase Chain Reaction. Protein Binding. Transfection

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  • (PMID = 15671042.001).
  • [ISSN] 1535-9476
  • [Journal-full-title] Molecular & cellular proteomics : MCP
  • [ISO-abbreviation] Mol. Cell Proteomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; EC 5.2.1.- / Tacrolimus Binding Proteins
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83. Uschuplich V, Hilsenbeck JR, Velasco CR: Paratesticular mucinous cystadenoma arising from an oviduct-like müllerian remnant: a case report and review of the literature. Arch Pathol Lab Med; 2006 Nov;130(11):1715-7
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  • Mucinous cystadenomas of the testis and paratestis are extremely rare benign tumors of controversial origin.
  • A few case reports and reviews of testicular and paratesticular mucinous neoplasms resembling ovarian tumors have suggested the possibility of a müllerian origin of these tumors.
  • The current case demonstrates a clear transition from müllerian-type tubal epithelium to intestinal-type mucinous epithelium.
  • [MeSH-major] Cystadenoma, Mucinous / etiology. Cystadenoma, Mucinous / pathology. Mullerian Ducts / pathology. Testicular Neoplasms / etiology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Immunohistochemistry. Immunophenotyping. Intestinal Mucosa / pathology. Male

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  • (PMID = 17076537.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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84. Khoury T, Chadha K, Javle M, Donohue K, Levea C, Iyer R, Okada H, Nagase H, Tan D: Expression of intestinal trefoil factor (TFF-3) in hepatocellular carcinoma. Int J Gastrointest Cancer; 2005;35(3):171-7
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  • [Title] Expression of intestinal trefoil factor (TFF-3) in hepatocellular carcinoma.
  • BACKGROUND: Trefoil peptides (TFF-1, 2, 3) are a family of protease-resistant regulatory factors that play a role in mucosal restitution, angiogenesis, apoptosis, and tumor progression.
  • Intestinal trefoil peptide (TFF-3) expression has been demonstrated in benign hepatobiliary diseases, but there are limited data regarding its expression in HCC.
  • Tumor/ normal tissue interface was assessable in 21 cases; 11 cases expressed TFF-3 at the interface.
  • There was a strong correlation between tumor grade and TFF-3 expression, wherein poorly differentiated tumors had moderate/strong TFF-3 expression (p = 0.008).
  • CONCLUSION: TFF-3 is commonly expressed in HCC and its expression correlates with tumor grade.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Liver Neoplasms / metabolism. Peptides / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Analysis. Trefoil Factor-2

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  • (PMID = 16110118.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides; 0 / Trefoil Factor-2
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85. Kars M, Roelfsema F, Romijn JA, Pereira AM: Malignant prolactinoma: case report and review of the literature. Eur J Endocrinol; 2006 Oct;155(4):523-34
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  • In general, the initial clinical, biochemical, and histological characteristics are of minimal utility in distinguishing benign adenomas from pituitary carcinomas.
  • In brief, it is postulated that pituitary carcinomas arise from the transformation of initially large, but benign, adenomas.
  • In vivo, the development of dopamine agonist resistance in invasive macroprolactinoma is indicative of malignancy and should prompt the clinician to perform a biopsy of the tumor.
  • For pituitary tumors that exhibit high mitotic activity, increased Ki-67 and/or p53 immunoreactivity, it may be useful to denote these tumors as 'atypical' prolactinomas to raise the possibility of future malignant development.

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  • (PMID = 16990651.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzamides; 0 / Pyrrolidines; 107188-87-4 / epidepride; 9002-62-4 / Prolactin
  • [Number-of-references] 47
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86. Lee SH, Lee DS, You IY, Jeon WJ, Park SM, Youn SJ, Choi JW, Sung R: [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. Korean J Gastroenterol; 2010 Feb;55(2):119-26
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  • METHODS: Among 1,847 cholecystectomized specimens, 63 specimens from 26 benign adenomas, 9 carcinomas in situ (CIS), and 28 invasive carcinomas were selected.
  • A pathologist reviewed all specimens and selected benign adenomas, CIS in the adenoma, and adenoma residue in invasive carcinomas.
  • Adenomas and adenoma-related lesions were classified according to morphology (tubular, tubulopapillary, and papillary) and the consisting epithelium (biliary, pyloric metaplasia, and intestinal metaplasia).
  • The age and the size of the benign adenomas and carcinomas in the adenoma were also compared.
  • All eight carcinomas arising in the adenoma were well-differentiated solitary tumors.
  • The diameters of the carcinomas in the adenoma were, on average, larger than that of the benign adenomas (1.8 cm vs. 0.9 cm, p=0.01).
  • The patients with carcinomas in the adenoma were, on average, older than those with benign adenomas, although the difference was insignificant (57 years vs. 47 years, p=0.09).
  • The morphology and consisting epithelium did not differ between the benign adenomas and carcinomas in the adenoma.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Adult. Age Factors. Aged. Carcinoma / epidemiology. Carcinoma / pathology. Carcinoma / surgery. Cell Transformation, Neoplastic. Cholecystectomy. Cystadenoma / epidemiology. Cystadenoma / pathology. Cystadenoma / surgery. Female. Gallstones / complications. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 20168058.001).
  • [ISSN] 2233-6869
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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87. Chiu YC, Lin JW, Changchien CS, Huang CC, Liu SY, Yi LN, Chiu KW, Wu KL, Chen YY, Chou FF, Hu TH: Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors. J Formos Med Assoc; 2005 Dec;104(12):905-12
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  • [Title] Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors.
  • BACKGROUND AND PURPOSE: Gastrointestinal stromal tumors (GISTs) involving the small intestine are less common than those involving the stomach, and data on small intestinal stromal tumors (SISTs) are more limited.
  • This study investigated the clinicopathological characteristics and prognostic factors of SISTs and compared them with those of gastric stromal tumors (GSTs).
  • METHODS: A total of 82 surgically resected and pathologically diagnosed smooth muscle tumors of small bowel in patients treated from January 1986 to December 2000 were included.
  • Immunohistochemical studies were performed on these tumors with antibodies of CD117, CD34, smooth muscle actin (SMA), desmin and S-100.
  • RESULTS: Among the 82 small intestine tumors, 71 were CD117-positive (86.6%) and were classified as SISTs.
  • Survival analysis demonstrated that tumor size < 5 cm (p = 0.021), mitosis number < 5/50 high-power field (p < 0.001), SMA-positive (p = 0.027), non-epithelioid cell type (p = 0.005) and tumor with skeinoid fibers (p = 0.010) predicted longer disease-free survival after operation.
  • Multivariate analysis revealed that mitotic number (p = 0.001), cell morphology (p = 0.031) and tumor size (p = 0.004) were independent prognostic factors.
  • SMA reactivity is a predictor of benign clinical behavior in SISTs.
  • Tumor mitotic numbers, tumor size, and cell type were independent prognostic factors for patients with SISTs after operation.

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  • (PMID = 16607447.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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88. Priest JR, Williams GM, Hill DA, Dehner LP, Jaffé A: Pulmonary cysts in early childhood and the risk of malignancy. Pediatr Pulmonol; 2009 Jan;44(1):14-30
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  • The earliest manifestation of PPB is a malignant lung cyst in young children, clinically and radiographically indistinguishable from benign congenital lung cysts.
  • Histopathologic examination differentiates cystic PPB from the benign cystic variants.
  • Detailed family history may reveal the hallmarks of PPB in the patient or young relatives: a unique constellation of diseases including lung cysts, cystic nephroma, childhood cancers, stromal sex-chord ovarian tumors, seminomas or dysgerminomas, intestinal polyps, thyroid hyperplasias, and hamartomas.
  • These diagnoses predict that a lung cyst is more likely PPB than a benign congenital cyst.
  • [MeSH-major] Cysts / pathology. Lung Diseases / pathology. Lung Neoplasms / pathology. Pleural Neoplasms / pathology

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • [CommentIn] Pediatr Pulmonol. 2010 Jan;45(1):103; author reply 104 [19960525.001]
  • (PMID = 19061226.001).
  • [ISSN] 1099-0496
  • [Journal-full-title] Pediatric pulmonology
  • [ISO-abbreviation] Pediatr. Pulmonol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 94
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89. Sunamak O, Karabicak I, Aydemir I, Aydogan F, Guler E, Cetinkaya S, Korman MU: An intraluminal leiomyoma of the small intestine causing invagination and obstruction: a case report. Mt Sinai J Med; 2006 Dec;73(8):1079-81
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  • [Title] An intraluminal leiomyoma of the small intestine causing invagination and obstruction: a case report.
  • Leiomyomas are mostly of benign character and are rarely seen in the gastrointestinal (GI) system.
  • They represent one subgroup of a group of tumors known as gastrointestinal stromal tumors (GIST).
  • Although rarely seen, they are symptomatic tumors, and they comprise 20-30 percent of all benign GI tumors.
  • This is a case report of intestinal leiomyoma in a patient who was suffering with GI obstruction for more than 5 months.
  • The tumor was discovered only after the appearance of intestinal obstruction.
  • [MeSH-major] Gastrointestinal Stromal Tumors / complications. Ileal Neoplasms / complications. Intussusception / etiology. Jejunal Neoplasms / complications. Leiomyoma / complications
  • [MeSH-minor] Aged. Female. Humans. Intestine, Small / pathology

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  • (PMID = 17285198.001).
  • [ISSN] 0027-2507
  • [Journal-full-title] The Mount Sinai journal of medicine, New York
  • [ISO-abbreviation] Mt. Sinai J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Nguyen VX, Nguyen CC, Li B, Das A: Digital image analysis is a useful adjunct to endoscopic ultrasonographic diagnosis of subepithelial lesions of the gastrointestinal tract. J Ultrasound Med; 2010 Sep;29(9):1345-51
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  • [Title] Digital image analysis is a useful adjunct to endoscopic ultrasonographic diagnosis of subepithelial lesions of the gastrointestinal tract.
  • OBJECTIVE: The purpose of this study was to explore the role of digital image analysis in differentiating endoscopic ultrasonographic (EUS) features of potentially malignant gastrointestinal subepithelial lesions (SELs) from those of benign lesions.
  • METHODS: Forty-six patients with histopathologically confirmed gastrointestinal stromal tumors (GISTs), carcinoids, and lipomas who had undergone EUS evaluation were identified from our database.
  • [MeSH-major] Endosonography. Gastrointestinal Neoplasms / ultrasonography. Image Interpretation, Computer-Assisted / methods
  • [MeSH-minor] Area Under Curve. Carcinoid Tumor / pathology. Carcinoid Tumor / ultrasonography. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / ultrasonography. Humans. Intestinal Mucosa / pathology. Lipoma / pathology. Lipoma / ultrasonography. Neural Networks (Computer). Principal Component Analysis

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  • (PMID = 20733191.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Koç M, Göçmen E, Kiliç M, Ozbay M, Oktem M, Tez M: Serum endostatin levels in gastric cancer patients: correlation with clinicopathological parameters. Hepatogastroenterology; 2006 Jul-Aug;53(70):616-8
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  • We measured serum endostatin levels of 30 patients aged between 34-83 years with gastric cancer and 30 patients without malignant pathology operated for benign pathologies with age ranging from 18 to 69.
  • Significantly higher serum endostatin levels were obtained in Lauren intestinal type tumors than Lauren diffuse type tumors.
  • CONCLUSIONS: These data suggest that serum endostatin levels do not correlate with clinicopathological parameters, except tumor histopathology (according to Lauren classification), in gastric cancer patients.
  • [MeSH-major] Angiogenesis Inhibitors / blood. Endostatins / blood. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neovascularization, Pathologic

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  • (PMID = 16995474.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Endostatins
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92. Gagliano E, Tonante A, Lo Schiavo MG, Bonanno L, Taranto F, Sturniolo G: [Ileal leiomyosarcoma presenting with an episode of acute massive intestinal bleeding]. Chir Ital; 2006 Jul-Aug;58(4):519-24
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  • [Title] [Ileal leiomyosarcoma presenting with an episode of acute massive intestinal bleeding].
  • The aim of this article was to present a case of gastrointestinal stromal tumour (GIST) presenting with acute intestinal bleeding.
  • Histological criteria are by no means of absolute value: tumours considered benign on the basis of histology may present a malignant behaviour in the course of time, with the development of metastases and recurrences.
  • In this regard, a number of predictive malignancy indices have been identified such as the patient's age, tumour size, presence of haemorrhage and necrotic areas, high mitotic index (> 5 mitoses/50 HFP), and kit-gene mutations.
  • The Authors stress the diagnostic importance of 99m Tc-RBC scintigraphy in the case reported and agree with the literature as to the appropriate therapy, consisting in intestinal resection.
  • The therapy of active GIST is essentially surgical and consists in resection of the intestinal tract affected by the tumour: lymphadenectomy must be performed only in case of need, because GIST metastasis preferably via the blood stream.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Ileal Neoplasms / complications. Leiomyosarcoma / complications
  • [MeSH-minor] Female. Gastrointestinal Stromal Tumors / complications. Humans. Middle Aged. Radiopharmaceuticals. Technetium. Treatment Outcome


93. Spaventa-Ibarrola A, Decanini-Terán C, Becerril-Martínez G, Menéndez-Skertchly AL, Golffier-Rosete C: [Ileocecal valve lipoma. Case report and review of the literature]. Cir Cir; 2006 Jul-Aug;74(4):279-82
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  • BACKGROUND: Lipomas are the most frequent benign tumors of the digestive tract and 50% are localized in the colon.
  • CASE PRESENTATION: We present the case of a 78-year-old female with intermittent small bowel occlusion, abdominal distention and constipation.
  • Colonoscopy showed a submucous tumor at the ICV, CT scan showed a tumor at the ICV with fat density.
  • Definitive pathology revealed a benign lipoma.
  • CONCLUSION: It is important to know the different presentations of these benign tumors because if there is mucosal ulceration they can be mistaken for a malignant lesion and lead to greater resections.
  • [MeSH-major] Ileal Neoplasms / diagnosis. Ileocecal Valve. Lipoma / diagnosis
  • [MeSH-minor] Aged. Female. Humans. Intestinal Obstruction / etiology

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  • (PMID = 17022901.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 21
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94. Badea R, Ciobanu L, Gomotirceanu A, Hagiu C, Socaciu M: Contrast ultrasonography--a necessary procedure for a better characterization of digestive tract pathology. Med Ultrason; 2010 Mar;12(1):73-80
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  • [Title] Contrast ultrasonography--a necessary procedure for a better characterization of digestive tract pathology.
  • The pathology of the digestive tract, extremely popular, with equal sex distribution, can have a clinical history of chronic illness or emergency.
  • Diagnosis is based on endoscopy (identifies the lesion, permits histological sample under visual control, and minimally invasive treatment for polypoid benign tumors).
  • Even so, the characteristics of the inflammatory diseases and the detection of tumors, particularly those with endoluminal development, can be difficult.
  • In recent years transabdominal ultrasound examination of the digestive tract was supplemented with more precise methods of investigation of the lumen and circulation of the intestinal wall.

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  • (PMID = 21165458.001).
  • [ISSN] 1844-4172
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Contrast Media
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95. Fukumoto A, Tanaka S, Shishido T, Oka S, Chayama K: [Diagnosis and treatment for benign small bowel tumor]. Nihon Rinsho; 2008 Jul;66(7):1305-11
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  • [Title] [Diagnosis and treatment for benign small bowel tumor].
  • Even if small bowel tumors are benign, they need to be treated when they cause symptoms, such as gastrointestinal bleeding or enteric intussusception.
  • It became possible to perform endoscopic treatment for small bowel lesions using DBE.
  • Therefore for preventing surgical operation, it became important to detect small bowel tumors while endoscopic treatment is possible.
  • CE has potential to survey small bowel tumors, especially in patients with polyposis.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 18616121.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 20
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96. Chang WC, Sheu BC, Lin MC, Chow SN, Huang SC: Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report. Int J Gynecol Cancer; 2005 May-Jun;15(3):549-53
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  • [Title] Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report.
  • Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms.
  • Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy.
  • Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were performed, and the frozen pathology during operation showed mucinous tumor of borderline malignancy of left ovary on April 18, 2002.
  • It is difficult to determine whether intestinal-type borderline mucinous tumors with intraepithelial carcinoma are associated with a worse prognosis compared with those with epithelial atypia alone due to disparate results in the published literature.
  • However, too few cases of carcinosarcoma-like mural nodule in mucinous tumor have been published to warrant a conclusion regarding their prognosis.
  • [MeSH-major] Carcinosarcoma / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Prognosis

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  • (PMID = 15882184.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Rother T, Knöpfle E, Bohndorf K: [Virtual colonoscopy--and then? Relevance of small colorectal polyps]. Rofo; 2007 Feb;179(2):130-6
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  • [Title] [Virtual colonoscopy--and then? Relevance of small colorectal polyps].
  • Colorectal carcinomas are the second most frequent malignant tumors in Germany and originate predominantly from benign polyps (adenoma-carcinoma sequence).
  • 30 %) of colon polyps in the screening population, virtual colonoscopy is useful for screening only, if a small number of the lesions must be subsequently removed endoscopically.
  • According to a comprehensive review of the literature, the risk potential of small polyps up to a size of 5 - 6 mm can be summarized as follows: Up to 75 % of all polyps found in screening programs belong to the group of "small polyps".
  • The very few existing growth studies cannot provide reliable information about how quickly these small lesions may turn malignant.
  • CONCLUSION: The risk potential of small polyps can be considered to be low.
  • Therefore, further studies examining the natural growth behavior of small polyps are necessary, before control examinations (in intervals of two to three years) rather than immediate endoscopic polypectomy can be recommended as an adequate approach in screening programs.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic. Colonoscopy. Colorectal Neoplasms / prevention & control. Intestinal Polyps / radiography

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  • (PMID = 17262241.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 42
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98. Daum O, Hatlova J, Mandys V, Grossmann P, Mukensnabl P, Benes Z, Michal M: Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). Virchows Arch; 2010 May;456(5):491-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors).
  • Vanek's tumor (inflammatory fibroid polyp) is a rare benign lesion occurring throughout the digestive tract.
  • Classical Vanek's tumor contains concentric formations of proliferating spindle cells which are CD34 positive.
  • Atypical, inflammatory pseudotumor-like Vanek's tumor lacks concentric formations and is CD34 negative.
  • Recently, mutations in platelet-derived growth factor receptor alpha (PDGFRA) were reported in gastric and small intestinal Vanek's tumors.
  • In this study, KIT exons 9, 11, 13, and 17, PDGFRA exons 12, 14, and 18, and a part of exon 15 BRAF for point mutation V600E were screened in 23 cases of Vanek's tumor, both classical (n = 16) and inflammatory pseudotumor-like (n = 7).
  • Six Vanek's tumors harbored activating mutations in PDGFRA exons 12 (n = 5) and 18 (n = 1) respectively: S566_E571delinsK (n = 1), S566_E571delinsR (n = 4), and D842 del (n = 1).
  • The mutations were detected in the classical (n = 5), as well as inflammatory pseudotumor-like (n = 1) Vanek's tumors.
  • The results of this study suggest that the two morphological patterns of Vanek's tumor more probably represent only variants of one type of tumor than two different lesions.
  • Furthermore, BRAF mutations were not shown to drive growth of PDGFRA wild-type Vanek's tumors.
  • [MeSH-major] Intestinal Diseases / pathology. Leiomyoma / genetics. Leiomyoma / pathology. Polyps / genetics. Polyps / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics. Stomach Diseases / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Exons. Female. Gastrointestinal Tract / pathology. Humans. Male. Middle Aged. Mutation. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 20393746.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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99. Guth S, Gocke C, Gebhardt J, Schwenk W, Caselitz J, Bamberger CM: [Mesenterial lymphangiolipoma - a rare finding in an asymptomatic patient]. Med Klin (Munich); 2010 Dec;105(12):948-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Lymphangioma is an uncommon tumor, an intraperitoneal lymphangiolipoma is exceedingly rare.
  • These tumors are principally benign, but lead to complications due to their size and localization.
  • Abdominal ultrasound revealed a large polycystic lesion in the right middle and lower abdomen, approximately 12x10x7 cm in size.
  • In MRI, the tumor appeared cystic as well without communication to the intestinal wall.
  • CONCLUSION: Lymphangiomas, especially lymphangiolipomas, are an extremely rare differential diagnosis of intraabdominal cystic tumors.
  • [MeSH-major] Incidental Findings. Lipoma / diagnosis. Lymphangioma / diagnosis. Mesentery. Peritoneal Neoplasms / diagnosis

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  • (PMID = 21240596.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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100. Yang Y, Nie X, Lu J, Lu XY, Wei YY, Wang H, Han ZH, Chen ZH, Zheng J: [Mixed epithelial and stromal tumor of kidney]. Zhonghua Bing Li Xue Za Zhi; 2006 Jan;35(1):29-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mixed epithelial and stromal tumor of kidney].
  • OBJECTIVE: To study the clinicopathological features and differential diagnoses of mixed epithelial and stromal tumor of the kidney.
  • METHODS: Clinical and pathological characteristics of 4 cases of mixed epithelial and stromal tumor of the kidney were studied.
  • Grossly the tumors had a solid and cyst appearance.
  • Microscopically, the tumors were composed of a mixture of stromal and epithelial elements.
  • One case showed Müllerian and intestinal epithelial differentiations.
  • Stromal elements essentially consisted of spindle cells, with thick-walled blood vessels and bands of smooth muscle cells as distinctive features of the tumor.
  • CONCLUSIONS: Mixed epithelial and stromal tumor of the kidney is a benign neoplasm with distinct histopathological features.
  • It should be distinguished from many other renal neoplasms.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 16608646.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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