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1. Guillen-Ahlers H, Suckow MA, Castellino FJ, Ploplis VA: Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PLoS One; 2010 Feb 05;5(2):e9070
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  • [Title] Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.
  • BACKGROUND: Fas, a member of the tumor necrosis family, is responsible for initiating the apoptotic pathway when bound to its ligand, Fas-L.
  • One of the main limitations of the Apc(Min/+) mouse model is that it only develops benign polyps.
  • However, Apc(Min/+)/Fas(lpr) mice presented with a dramatic increase in tumor burden relative to Apc(Min/+) mice and invasive lesions at advanced ages.
  • CONCLUSIONS/SIGNIFICANCE: This study demonstrated that imposition of a Fas deletion in an Apc(Min/+) background results in a more aggressive phenotype of the Apc(Min/+) mouse model, with more rapid development of invasive intestinal tumors and a decrease in Fas-L levels.

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  • (PMID = 20140201.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / P01 HL073750; United States / NHLBI NIH HHS / HL / HL 73750
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Antigens, CD95; 0 / Fas Ligand Protein; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2816700
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2. Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K: Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell; 2008 May;13(5):407-19
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  • [Title] Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
  • The Drosophila transcription factor Prospero functions as a tumor suppressor, and it has been suggested that the human counterpart of Prospero, PROX1, acts similarly in human cancers.
  • PROX1 expression marks the transition from benign colon adenoma to carcinoma in situ, and its loss inhibits growth of human colorectal tumor xenografts and intestinal adenomas in Apc(min/+) mice, while its transgenic overexpression promotes colorectal tumorigenesis.
  • Furthermore, in intestinal tumors PROX1 is a direct and dose-dependent target of the beta-catenin/TCF signaling pathway, responsible for the neoplastic transformation.
  • Our data underscore the complexity of cancer pathogenesis and implicate PROX1 in malignant tumor progression through the regulation of cell polarity and adhesion.
  • [MeSH-major] Adenoma / genetics. Colonic Neoplasms / genetics. Homeodomain Proteins / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Carcinoma in Situ / genetics. Cell Line, Tumor. Colorectal Neoplasms / genetics. Disease Progression. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Phenotype. beta Catenin / physiology

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  • (PMID = 18455124.001).
  • [ISSN] 1878-3686
  • [Journal-full-title] Cancer cell
  • [ISO-abbreviation] Cancer Cell
  • [Language] eng
  • [Grant] United Kingdom / Worldwide Cancer Research / / 09-0791; United Kingdom / Medical Research Council / / G0301154
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / beta Catenin; 0 / prospero-related homeobox 1 protein
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3. Sanada Y, Yoshida K: A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes. J Gastrointestin Liver Dis; 2008 Dec;17(4):457-60
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  • [Title] A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes.
  • Here we report a case of benign intraductal papillary-mucinous neoplasm (IPMN) of the pancreas containing two major subtypes.
  • Histopathologic examinations revealed that IPMN was composed of gastric-type adenoma and intestinal-type borderline lesion.
  • Marked intraluminal nodular growth was observed in the center of the tumor composed of intestinal-type cells positive for MUC2.
  • Our observations suggest that gastric-type epithelium is a precursor of intestinal-type lesions in the stepwise progression of IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Mixed Tumor, Malignant / diagnosis. Pancreatic Neoplasms / diagnosis

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  • [CommentIn] J Gastrointestin Liver Dis. 2009 Jun;18(2):251-2 [19565062.001]
  • (PMID = 19104710.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Mucin-2
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4. Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M: Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol; 2005 Sep 7;11(33):5226-8
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  • [Title] Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report.
  • Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract.
  • Although rare, it is the most common primary tumor of the mesentery and can develop at any age.
  • We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST).
  • This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall.
  • Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor STI571 (imatinib mesylate) has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 16127758.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320401
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5. Yimyaem P, Saranrittichai S, Sinawat P, Dhiensiri T: Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant. J Med Assoc Thai; 2009 Jan;92(1):114-9
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  • [Title] Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant.
  • Benign intestinal tumors are rare in children; however, the authors describe an inflammatory myofibroblastic tumor (IMT) of the terminal ileum in a 2-month-old infant who presented with an intestinal obstruction.
  • A review of the literature for this rare condition was done to delineate the natural history of this tumor and to do a histological confirmation of its benign nature.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Ileal Diseases / pathology. Intestinal Obstruction / pathology

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  • (PMID = 19260252.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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6. Idema DL, Daryanani D, Sterk LM, Klaase JM: Collision tumor of the stomach: a case of an adenocarcinoma and a gastrointestinal stromal tumor. Case Rep Gastroenterol; 2008 Sep;2(3):456-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collision tumor of the stomach: a case of an adenocarcinoma and a gastrointestinal stromal tumor.
  • A collision tumor of the stomach is a rare event.
  • We report the case of a collision tumor of the stomach consisting of an adenocarcinoma and a gastrointestinal stromal tumor (GIST).
  • A 71-year-old man with abdominal discomfort underwent an esophagogastroduodenoscopy which revealed a tumor of the oesophagogastric junction.
  • Histologic examination showed a mixed tumor consisting of a primary adenocarcinoma and multiple nodules of GIST.
  • The adenocarcinoma showed both diffuse and intestinal growth, angio-invasion and metastasis to lymph nodes.
  • The GIST tumor cells were strongly immunoreactive to CD117 and CD34.
  • Based on mitotic index, size and cytonuclear details, the biological behavior of this GIST tumor was supposed to be benign.
  • This case reports the rare finding of a collision tumor consisting of an adenocarcinoma and a GIST with an unknown etiology.

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  • (PMID = 21897799.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3166811
  • [Keywords] NOTNLM ; Adenocarcinoma / Collision tumor / Gastrointestinal stromal cell tumor / Gastrointestinal stromal tumor / Stomach
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7. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA: Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer; 2008;7:94
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  • [Title] Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers.
  • BACKGROUND: Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact.
  • This study aims to pinpoint epigenetic markers that can discriminate between non-malignant and malignant tissue from the large bowel, i.e. markers with diagnostic potential.
  • Possible CIMP tumors were identified by comparing the methylation profile with microsatellite instability (MSI), BRAF-, KRAS-, and TP53 mutation status.
  • RESULTS: The mean number of methylated genes per sample was 0.4 in normal colon mucosa from tumor-free individuals, 1.2 in mucosa from cancerous bowels, 2.2 in adenomas, and 3.9 in carcinomas.
  • The promoters of ADAMTS1, MAL, and MGMT were frequently methylated in benign samples as well as in malignant tumors, independent of microsatellite instability.
  • In contrast, normal mucosa samples taken from bowels without tumor were rarely methylated for the same genes.
  • CONCLUSION: Methylated ADAMTS1, MGMT, and MAL are suitable as markers for early tumor detection.
  • [MeSH-major] Biomarkers, Tumor / analysis. Colonic Neoplasms / genetics. Colonic Neoplasms / pathology. DNA Methylation. Early Detection of Cancer. Genes, Neoplasm. Intestinal Mucosa / metabolism
  • [MeSH-minor] Adenoma / genetics. Adult. Aged. Aged, 80 and over. Cluster Analysis. DNA, Neoplasm / metabolism. Epigenesis, Genetic. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Microsatellite Instability. Microsatellite Repeats / genetics. Middle Aged. Promoter Regions, Genetic. Sex Characteristics

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  • (PMID = 19117505.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2639620
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8. Safioleas MC, Constantinos K, Michael S, Konstantinos G, Constantinos S, Alkiviadis K: Benign multicystic peritoneal mesothelioma: a case report and review of the literature. World J Gastroenterol; 2006 Sep 21;12(35):5739-42
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  • [Title] Benign multicystic peritoneal mesothelioma: a case report and review of the literature.
  • Benign multicystic peritoneal mesothelioma (BMPM) is a rare tumor that occurs mainly in women in their reproductive age.
  • Upright plain abdominal film revealed small bowel loops with air-fluid levels.
  • She was diagnosed having an incarcerated incisional hernia that resulted in intestinal obstruction.
  • The patient underwent surgery during which a cystic mass of the right ovary measuring 6 cm multiply 5 cm multiply 4 cm, four small cysts of the small bowel (1 cm in diameter) and a cyst at the retroperitoneum measuring 11 cm multiply 10 cm multiply 3 cm were found.
  • [MeSH-major] Mesothelioma, Cystic / diagnosis. Mesothelioma, Cystic / pathology. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasms / diagnosis. Neoplasms / etiology. Neoplasms / pathology. Neoplasms / surgery

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  • (PMID = 17007034.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 49
  • [Other-IDs] NLM/ PMC4088182
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9. Uenoyama Y, Seno H, Fukuda A, Sekikawa A, Nanakin A, Sawabu T, Kawada M, Kanda N, Suzuki K, Yada N, Fukui H, Chiba T: Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway. Oncogene; 2006 Jun 1;25(23):3277-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway.
  • Cyclooxygenase-2 (COX-2) plays important roles in tumor development.
  • Especially in the early-stage colorectal tumors, COX-2 expression is often observed in the tumor stroma.
  • In the present study, we simulated the indirect interaction between epithelial cells and stromal cells in the process of colorectal tumor development using an in vitro co-culture model in which NIH3T3 fibroblasts were co-cultured with 'sparsely' or 'densely' populated intestinal epithelial cells, Intestine-407 as a model of premalignant or benign intestinal epithelial cells, and DLD-1 and Caco-2 as models of malignant epithelial cells.
  • Interestingly, there was pericellular hypoxia in the vicinity of NIH3T3 fibroblasts when co-cultured with 'dense' epithelial cells, and the recovery of the partial pressure of oxygen level resulted in the reduction of enhanced COX-2 expression only in NIH3T3 fibroblasts co-cultured with 'dense' Intestine-407 cells.
  • Thus, pericellular hypoxia of the stromal cells caused by densely populated epithelial cells may be one of the potent COX-2 enhancers before completion of malignant transformation during intestinal tumor development.
  • [MeSH-major] Anoxia / enzymology. Cyclooxygenase 2 / biosynthesis. Intestinal Mucosa / cytology. Intestinal Mucosa / enzymology. Membrane Proteins / biosynthesis. Signal Transduction / physiology. Transcription Factor AP-1 / physiology
  • [MeSH-minor] Animals. Caco-2 Cells. Cell Count. Cell Line, Tumor. Coculture Techniques. Enzyme Induction / physiology. Humans. Mice. NIH 3T3 Cells. Precancerous Conditions / enzymology. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Stromal Cells / enzymology. Stromal Cells / pathology

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  • (PMID = 16407821.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Transcription Factor AP-1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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10. Lebeau R, Koffi E, Diané B, Amani A, Kouassi JC: [Acute intestinal intussusceptions in adults: analysis of 20 cases]. Ann Chir; 2006 Oct;131(8):447-50
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  • [Title] [Acute intestinal intussusceptions in adults: analysis of 20 cases].
  • AIM OF THE STUDY: To report our experience in the management of acute intestinal intussusceptions in adults.
  • PATIENTS AND METHODS: Retrospective study of data of patients older than 15 years who were operated on for acute intestinal intussusceptions from January 1997 to December 2001.
  • Correct preoperative diagnosis of acute intestinal intussusceptions was established in 6 cases.
  • Necrosis was found in the intussusceptum in 10 cases and a tumor on the lead point in 14 cases (5 benign lesions and 9 malignant ones).
  • For intussusception involving the colon, all patients underwent en bloc resection with immediate anastomosis, while intussusception located on the small bowel were treated by surgical reduction (N = 1), en bloc resection (N = 8) with immediate (N = 7) or delayed (N = 1) anastomosis.
  • En bloc resection is recommended because of the frequency of neoplasms and bowel ischemia.

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  • (PMID = 16765901.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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11. Mongardini M, Iachetta RP, Cola A, Brunelli D, Degli Effetti E, Blasi S, Maturo A, Benedetti F, Custureri F: [Gastric lipoma presenting as intestinal obstruction]. G Chir; 2006 Mar;27(3):90-2
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  • [Title] [Gastric lipoma presenting as intestinal obstruction].
  • Gastric lipoma is a rare benign tumor.
  • The symptoms are correlated with the size and the dimensions of neoplasm.
  • It can be the cause of bleeding, gastroduodenal intussusception and intestinal obstruction, as in case reported and surgically treated.
  • [MeSH-major] Intestinal Obstruction / etiology. Lipoma / complications. Lipoma / diagnosis. Stomach Neoplasms / complications. Stomach Neoplasms / diagnosis

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  • (PMID = 16681867.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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12. Sibio S, Borrini F, Sammartino P, Accarpio F, Biacchi D, Caprio G, Iafrate F, Baccheschi AM, Cornali T, Di Giorgio A: Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features. Endocr Pathol; 2010 Sep;21(3):199-203
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  • [Title] Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features.
  • Brenner tumor and struma ovarii, two uncommon ovarian tumors arising alone or together with dermoid cysts or adenomas, are both rare entities.
  • Both tumors rarely become malignant and rarely metastasize.
  • Few published reports describe coexisting Brenner tumor and malignant struma ovarii.
  • The patient we describe, a 74-year-old woman, presented with a 2 months' history of lower abdominal pain and episodic intestinal subocclusion due to a complex pelvic mass.
  • The mass consisted predominantly of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that had undergone malignant transformation into a well-differentiated papillary carcinoma and also normal thyroid tissue that had spread to the peritoneum.
  • [MeSH-major] Brenner Tumor / pathology. Carcinoma, Papillary / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary. Struma Ovarii / secondary
  • [MeSH-minor] Aged. Breast Neoplasms / complications. Carcinoma, Ductal, Breast / complications. Female. Humans. Neoplasms, Second Primary / pathology. Tomography, X-Ray Computed

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  • (PMID = 20532676.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Chiesa AG, Deavers MT, Veras E, Silva EG, Gershenson D, Malpica A: Ovarian intestinal type mucinous borderline tumors: are we ready for a nomenclature change? Int J Gynecol Pathol; 2010 Mar;29(2):108-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian intestinal type mucinous borderline tumors: are we ready for a nomenclature change?
  • At a National Cancer Institute-sponsored workshop it was proposed that the borderline category of ovarian intestinal-type mucinous tumors (OInMTs) could be eliminated if the apparent benign behavior of these tumors could be confirmed.
  • Optimal sampling and adequate sampling were defined as at least 1 section per centimeter of maximum tumor dimension and at least 1 section per 2 cm of maximum tumor dimension, respectively.
  • Tumor size ranged from 8 to 39 cm (mean 20 cm).
  • The sampling of the ovarian tumor was optimal in 28 cases and adequate in 5 cases.
  • The tumor was incompletely removed and recurred in the pelvis 1 year later.
  • Ten months later, the tumor re-recurred in the pelvis and could only be drained because of the patient's advanced age and her poor medical status.
  • The second patient with recurrent tumor had undergone a cystectomy and full staging for a borderline OInMT.
  • However, borderline OInMTs are usually large and heterogeneous, and the standard sampling protocol for them is not evidence based.
  • [MeSH-major] Adenocarcinoma, Mucinous / classification. Adenocarcinoma, Mucinous / pathology. Ovarian Neoplasms / classification. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Histocytochemistry. Humans. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Retrospective Studies. Terminology as Topic. Young Adult

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  • [CommentIn] Int J Gynecol Pathol. 2010 Nov;29(6):552-3; author reply 553-4 [20881857.001]
  • (PMID = 20173495.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Yang WL, Zhang XC, Yan ZQ, Zhang HM, Zhao Z, Zhang JG, Wang YJ: [Clinical analysis of primary small intestinal neoplasms in 305 cases]. Zhonghua Zhong Liu Za Zhi; 2007 Oct;29(10):781-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of primary small intestinal neoplasms in 305 cases].
  • OBJECTIVE: To summarive the experience in diagnosis and treatment of primary small intestinal neoplasm.
  • METHODS: The data of 305 patients with pathologically confirmed primary small intestinal tumor collected from 6 hospitals around the Songhua River during the past 33 years were analyzed retrospectively.
  • RESULTS: There were 42 benign and 263 malignant tumors in this series with a ratio of 1: 6.26.
  • The 263 malignant tumors in this series consisted of 135 adenocarcinomas, 57 malignant stromal tumors, 37 malignant lymphomas, 20 carcinoids, and etc.
  • Chronic occult bleeding, gradual of body weight loss and mild abdominal pain (three obscurities) were the common clinical features and alerting massage of intestinal tumor.
  • Correct preoperative diagnostic rate was only 57.0% (174/305) due to difficulty in early diagnosis, which was 67.2% (92/137) in the duodenal tumors, and 51.9% (82/168) in the jejunoileal tumors.
  • All of the 42 benign tumors were resected completely.
  • For the 263 patients with malignant tumors, radical dissection was performed in 153, palliative resection in 34, and gut by-pass or biopsy in 76.
  • The median survival of the patients who underwent radical resection of their malignant tumors was 92 months, which was significantly higher than that of the other groups.
  • CONCLUSION: Early diagnosis of primary small intestinal tumors is difficult and with a preoperative misdiagnosis rate of 43.0%.
  • Total intestinal barium swallowing, endoscopy and superior mesenteric arteriography are three critical examinations for diagnosis and location.
  • The primary small intestinal tumor should be resected as early as possible if no distant metastasis is detected.
  • [MeSH-major] Adenocarcinoma. Diagnostic Errors. Digestive System Surgical Procedures / methods. Duodenal Neoplasms
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / diagnosis. Carcinoid Tumor / secondary. Carcinoid Tumor / surgery. Female. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / secondary. Gastrointestinal Stromal Tumors / surgery. Humans. Ileal Neoplasms / diagnosis. Ileal Neoplasms / pathology. Ileal Neoplasms / surgery. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lymphatic Metastasis. Lymphoma / diagnosis. Lymphoma / pathology. Lymphoma / surgery. Male. Middle Aged. Young Adult

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  • (PMID = 18396694.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Eriksen JR, Ibsen PH, Gyrtrup HJ: [Granular cell tumor of the colon--Abrikossoff's tumor]. Ugeskr Laeger; 2006 May 22;168(21):2080-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the colon--Abrikossoff's tumor].
  • [Transliterated title] Granularcelletumor i colon--Abrikossoffs tumor.
  • A 50-year-old woman had a right hemicoletomy due to a large sessile polyp in the ascending colon, inappropriate for polypectomy.
  • Histopathologic examination of the specimen showed a tubulovillous adenoma with moderate dysplasia and an adjacent 1 x 1 cm submucosal tumor classified as a benign GCT due to the appearance in the light microscope and immunohistochemical analysis.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Granular Cell Tumor / pathology
  • [MeSH-minor] Female. Humans. Intestinal Mucosa / pathology. Middle Aged

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  • (PMID = 16768929.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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16. Fukumoto A, Tanaka S, Shishido T, Oka S, Chayama K: [Diagnosis and treatment for benign small bowel tumor]. Nihon Rinsho; 2008 Jul;66(7):1305-11

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  • [Title] [Diagnosis and treatment for benign small bowel tumor].
  • Even if small bowel tumors are benign, they need to be treated when they cause symptoms, such as gastrointestinal bleeding or enteric intussusception.
  • It became possible to perform endoscopic treatment for small bowel lesions using DBE.
  • Therefore for preventing surgical operation, it became important to detect small bowel tumors while endoscopic treatment is possible.
  • CE has potential to survey small bowel tumors, especially in patients with polyposis.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 18616121.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 20
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17. Biermann K, Heukamp LC, Büttner R, Zhou H: Uterine tumor resembling an ovarian sex cord tumor associated with metastasis. Int J Gynecol Pathol; 2008 Jan;27(1):58-60
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  • [Title] Uterine tumor resembling an ovarian sex cord tumor associated with metastasis.
  • Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are very rare, usually benign uterine tumors, and are probably derived from uterine mesenchymal stem cells.
  • Four years after a diagnosis of UTROSCT of the uterine corpus, the patient developed obstructive ileus due to a large infiltrating tumor within the small bowel with the same morphology and expression pattern as the previously diagnosed UTROSCT.
  • In addition, 2 benign gastrointestinal stromal tumors were detected in the same patient.
  • This case indicates that although the majority of UTROSCT are benign tumors, some of them might undergo malignant transformation and have a metastatic potency.
  • [MeSH-major] Intestinal Neoplasms / secondary. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology. Humans. Immunohistochemistry. Intestinal Obstruction / etiology. Intestine, Small / metabolism. Intestine, Small / pathology. Neoplasms, Second Primary / metabolism. Neoplasms, Second Primary / pathology

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  • (PMID = 18156976.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Chiu YC, Lin JW, Changchien CS, Huang CC, Liu SY, Yi LN, Chiu KW, Wu KL, Chen YY, Chou FF, Hu TH: Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors. J Formos Med Assoc; 2005 Dec;104(12):905-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors.
  • BACKGROUND AND PURPOSE: Gastrointestinal stromal tumors (GISTs) involving the small intestine are less common than those involving the stomach, and data on small intestinal stromal tumors (SISTs) are more limited.
  • This study investigated the clinicopathological characteristics and prognostic factors of SISTs and compared them with those of gastric stromal tumors (GSTs).
  • METHODS: A total of 82 surgically resected and pathologically diagnosed smooth muscle tumors of small bowel in patients treated from January 1986 to December 2000 were included.
  • Immunohistochemical studies were performed on these tumors with antibodies of CD117, CD34, smooth muscle actin (SMA), desmin and S-100.
  • RESULTS: Among the 82 small intestine tumors, 71 were CD117-positive (86.6%) and were classified as SISTs.
  • Survival analysis demonstrated that tumor size < 5 cm (p = 0.021), mitosis number < 5/50 high-power field (p < 0.001), SMA-positive (p = 0.027), non-epithelioid cell type (p = 0.005) and tumor with skeinoid fibers (p = 0.010) predicted longer disease-free survival after operation.
  • Multivariate analysis revealed that mitotic number (p = 0.001), cell morphology (p = 0.031) and tumor size (p = 0.004) were independent prognostic factors.
  • SMA reactivity is a predictor of benign clinical behavior in SISTs.
  • Tumor mitotic numbers, tumor size, and cell type were independent prognostic factors for patients with SISTs after operation.

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  • (PMID = 16607447.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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19. Zang L, Hu WG, Yan XW, Zhang T, Ma JJ, Ye Q, Feng B, Wang ML, Lu AG, Li JW, Zhong J, Zheng MH: Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A; 2010 Jul-Aug;20(6):521-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment for small intestinal bleeding: a report of 77 cases.
  • BACKGROUND: Morbidity of small intestinal disease is rare and the associated lesion is hard to be detected due to lack of specific manifestations and effective diagnostic approaches.
  • Hematochezia and melena are the most common symptoms in small intestinal diseases.
  • Hence, small intestinal disease is an important differential diagnosis when hematochezia or melena occurs, especially when gastric and colonic diseases are excluded.
  • As the small intestinal lesion is hard to be located preoperatively, laparotomy used to be performed without a preoperative location.
  • With the development of laparoscopic technique, laparoscopic operations are more frequently applied to surgical disease, despite their benign or malignant nature.
  • Generally, almost all kinds of small intestinal disease can be treated with laparoscopic surgery.
  • METHODS: Clinical data of 77 patients with small intestinal bleeding undergoing laparoscopic or laparoscopy-assisted operations from April 2003 to December 2008 were included, and their clinical information were analyzed retrospectively.
  • There was 1 case of gastrointestinal stromal tumor with local recurrence and hepatic metastasis.
  • Four patients died from metastasis of malignant tumors during the follow-up from 2 to 70 months after operations.
  • CONCLUSIONS: Laparoscopic treatment in small intestinal bleeding is feasible, safe, and minimally invasive.
  • It may be widely used in the future for its good therapeutic outcomes and improved diagnostic chance in small intestinal bleeding diseases.
  • [MeSH-major] Gastrointestinal Hemorrhage / surgery. Intestine, Small. Laparoscopy
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Loss, Surgical. Female. Humans. Intestinal Neoplasms / diagnosis. Length of Stay. Male. Melena / diagnosis. Middle Aged. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):771 [20874417.001]
  • (PMID = 20687815.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Farnedi A, Eusebi LH, Poli F, Foschini MP: Immunohistochemical expression of the human sodium/iodide symporter distinguishes malignant from benign gastric lesions. Int J Surg Pathol; 2009 Aug;17(4):327-34
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  • [Title] Immunohistochemical expression of the human sodium/iodide symporter distinguishes malignant from benign gastric lesions.
  • MATERIALS AND METHODS: Seventy-seven samples were stained immunohistochemically with a monoclonal antibody for hNIS, including 14 with normal gastric mucosa, 14 with chronic atrophic gastritis with foveolar hyperplasia, 15 with chronic atrophic gastritis with intestinal metaplasia, 6 with chronic atrophic gastritis with atypical regenerative hyperplasia, 8 with chronic atrophic gastritis with dysplasia, 15 with invasive adenocarcinoma, 3 with well-differentiated neuroendocrine tumor, and 2 with gastrointestinal stromal tumors (GISTs).
  • RESULTS: hNIS stained the basolateral cytoplasmic portion of foveolae in normal mucosa, in 13 cases of chronic atrophic gastritis with foveolar hyperplasia, and in only 1 case of regenerative atypical hyperplasia. hNIS was consistently absent in intestinal metaplasia, in dysplastic glands, and in the cells constituting invasive carcinoma, well-differentiated neuroendocrine tumors, and GIST.
  • [MeSH-major] Gastritis, Atrophic / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Neuroendocrine Tumors / diagnosis. Precancerous Conditions / pathology. Stomach Neoplasms / diagnosis. Symporters / metabolism

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  • (PMID = 19124451.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Symporters; 0 / sodium-iodide symporter
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21. Emanuel P, Qin L, Harpaz N: Calcifying fibrous tumor of small intestine. Ann Diagn Pathol; 2008 Apr;12(2):138-41
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  • [Title] Calcifying fibrous tumor of small intestine.
  • Calcifying fibrous tumor (CFT) is a rare benign tumor with a predilection for children and young adults that usually arises in the subcutaneous and deep soft tissues, pleura, or peritoneum.
  • Calcifying fibrous tumor of the gastrointestinal tract is exceedingly rare and therefore prone to confusion with other spindle cell lesions more commonly encountered in this location.
  • We describe 4 cases of calcifying fibrous tumor arising in the terminal ileum, one of which caused the heretofore unreported complication of intestinal intussusception, and discuss the differential diagnosis with other common and uncommon spindle cell lesions.
  • [MeSH-major] Calcinosis / pathology. Fibroma / pathology. Ileal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibromatosis, Aggressive / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Humans. Male

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  • (PMID = 18325476.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Agaimy A, Stoehr R, Vieth M, Hartmann A: Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations. Am J Surg Pathol; 2010 Nov;34(11):1663-71
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  • [Title] Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations.
  • Colorectal fibroblastic polyp and intramucosal perineurioma are 2 synonyms for a recently described benign mucosal lesion with a predilection for the rectosigmoid colon.
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Epithelial Cells / pathology. Fibroblasts / pathology. Intestinal Mucosa / pathology. Mutation. Nerve Sheath Neoplasms / pathology. Proto-Oncogene Proteins B-raf / genetics. Stromal Cells / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. DNA Mutational Analysis. Female. Humans. Hyperplasia. Immunohistochemistry. Male. Middle Aged. Phosphatidylinositol 3-Kinases / genetics. Proto-Oncogene Proteins / genetics. ras Proteins / genetics

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  • (PMID = 20962618.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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23. Stojsic Z, Brasanac D, Kokai G, Vujovic D, Zivanovic D, Boricic I, Bacetic D: Intestinal intussusception due to a pyogenic granuloma. Turk J Pediatr; 2008 Nov-Dec;50(6):600-3
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  • [Title] Intestinal intussusception due to a pyogenic granuloma.
  • Pyogenic granuloma (PG), also known as lobular capillary hemangioma, is a benign vascular tumor, most commonly arising on the skin and the oral mucosa.
  • We describe a case of ileal PG occurring in a 13-year-old girl, presenting with intestinal obstruction.
  • Histological examination revealed proliferation of capillary-sized vessels, with prominent intravascular component, involving the entire thickness of the intestinal wall.

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  • (PMID = 19227429.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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24. Lin CY, Chen HY, Jwo SC, Chan SC: Ileal angiomyolipoma as an unusual cause of small-intestinal intussusception. J Gastroenterol; 2005 Feb;40(2):200-3
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  • [Title] Ileal angiomyolipoma as an unusual cause of small-intestinal intussusception.
  • Angiomyolipomas are benign mesenchymal tumors, but those that arise from the small intestine are exceedingly rare.
  • Small-bowel intussusception was shown on an abdominal computed tomography (CT) scan.
  • We discuss the clinical manifestations and clinicopathological and immunohistochemical findings of this benign tumor which appeared in this rare location.
  • [MeSH-major] Angiomyolipoma / complications. Ileal Neoplasms / complications. Intussusception / etiology

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  • (PMID = 15770405.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Desmin
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25. Okuma E, Ohishi Y, Oda Y, Aishima S, Kurihara S, Nishimura I, Yasunaga M, Kobayashi H, Wake N, Tsuneyoshi M: Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type. Oncol Rep; 2010 Dec;24(6):1569-76
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  • [Title] Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type.
  • Ovarian mucinous neoplasms of gastro-intestinal type (GI-type) are known to be a heterogeneous tumor composed of benign, borderline and non-invasive and invasive malignant lesions.
  • The presence of infiltrative invasion is also known to be an important prognostic factor of this neoplasm.
  • Laminin γ 2 chain, known to stimulate tumor cell invasion and migration, has not been sufficiently investigated in ovarian mucinous neoplasms.
  • The purpose of this study was thus to clarify the role of laminin γ 2 in ovarian mucinous neoplasms of GI-type.
  • We selected each morphological phase of tumor development from 61 cases of mucinous neoplasms of the GI-type: 55 adenoma lesions, 60 borderline lesions, 20 microinvasive lesions, 17 intraepithelial carcinoma lesions, 38 expansile invasive carcinoma lesions, 19 infiltrative invasive carcinoma lesions and 5 mural nodules lesions; and evaluated the localization of laminin γ 2 in the lesions using immunohistochemical method.
  • The infiltrative invasion of GI-type ovarian mucinous neoplasms may be promoted by cytoplasmic and/or stromal expression of laminin γ 2 chain.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Gastrointestinal Neoplasms / pathology. Laminin / metabolism. Neoplasm Staging / methods. Ovarian Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cohort Studies. Cytoplasm / metabolism. Disease Progression. Female. Humans. Models, Biological. Neoplasm Invasiveness. Prognosis. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 21042753.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / LAMC2 protein, human; 0 / Laminin
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26. Chiang JM, Lin YS: Tumor spectrum of adult intussusception. J Surg Oncol; 2008 Nov 1;98(6):444-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor spectrum of adult intussusception.
  • PATIENTS AND METHODS: Patients older than 16 years and diagnosed with intestinal intussusception between January 1990 and June 2006 were retrospectively reviewed.
  • RESULTS: Seventy-two patients underwent surgery for intestinal intussusception.
  • Neoplasm was identified as the cause of intussusception in 66 (92%) cases, and 6 (8%) were idiopathic.
  • Lipoma (15 of 40 patients, 38%) and Peutz-Jegher adenoma (10 of 40 patients, 25%) were the two most common lesions of benign small bowel neoplasms while 27% (3 of 11) of malignant enteric intussusception cases were malignant lymphoma and metastatic respectively.
  • CONCLUSION: Lipoma is the most common benign tumor in both small and large bowel intussusception.
  • Whereas 80% of tumors associated with small bowel intussusception were benign, two-thirds of colonic intussusceptions had resulted from primary adenocarcinoma.
  • [MeSH-major] Intestinal Diseases / etiology. Intestinal Neoplasms / complications. Intussusception / etiology
  • [MeSH-minor] Abdominal Pain / etiology. Adenocarcinoma / complications. Adenoma / complications. Adolescent. Adult. Aged. Aged, 80 and over. Cystadenocarcinoma, Mucinous / complications. Female. Humans. Lipoma / complications. Lymphoma, Large B-Cell, Diffuse / complications. Male. Middle Aged. Peutz-Jeghers Syndrome / complications. Retrospective Studies

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • [ErratumIn] J Surg Oncol. 2009 Jun 1;99(7):457
  • (PMID = 18668640.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Hajdú N, Zsoldos P, Neuberger G: [Rectum tumor diagnosed by subcutaneous emphysema of the chest]. Magy Seb; 2009 Oct;62(5):308-11
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  • [Title] [Rectum tumor diagnosed by subcutaneous emphysema of the chest].
  • BACKGROUND: Various benign and malignant thoracic or abdominal diseases can cause subcutaneous emphysema on the chest, pneumomediastinum or pneumopericardium.
  • Further examination revealed that this was caused by a rectal tumor causing large bowel obstruction and a consequent perforation of the transverse colon.
  • [MeSH-major] Colonic Diseases / surgery. Intestinal Obstruction / surgery. Rectal Neoplasms / complications. Rectal Neoplasms / diagnosis. Subcutaneous Emphysema / etiology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Intestinal Perforation / etiology. Mediastinal Emphysema / etiology. Pneumopericardium / etiology. Treatment Outcome


28. Chevrier L, Meunier AC, Cochaud S, Muller JM, Chadéneau C: Vasoactive intestinal peptide decreases MYCN expression and synergizes with retinoic acid in a human MYCN-amplified neuroblastoma cell line. Int J Oncol; 2008 Nov;33(5):1081-9
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  • [Title] Vasoactive intestinal peptide decreases MYCN expression and synergizes with retinoic acid in a human MYCN-amplified neuroblastoma cell line.
  • Neuroblastoma is a pediatric tumor which can spontaneously regress or differentiate into a benign tumor.
  • The neuropeptide vasoactive intestinal peptide (VIP) is known to control proliferation or differentiation of numerous cancer cells.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Neuroblastoma / metabolism. Nuclear Proteins / metabolism. Oncogene Proteins / metabolism. Tretinoin / pharmacology. Vasoactive Intestinal Peptide / pharmacology
  • [MeSH-minor] Carrier Proteins / metabolism. Cell Line, Tumor. Cell Shape / drug effects. Down-Regulation. Drug Synergism. Gene Expression Regulation, Neoplastic / drug effects. Heat-Shock Proteins / metabolism. Humans. Kinetics. RNA, Messenger / metabolism. S-Phase Kinase-Associated Proteins / metabolism

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  • (PMID = 18949372.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Carrier Proteins; 0 / Heat-Shock Proteins; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / S-Phase Kinase-Associated Proteins; 0 / TP53INP1 protein, human; 37221-79-7 / Vasoactive Intestinal Peptide; 5688UTC01R / Tretinoin
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29. Kelly RJ, Barrett C, Swan N, McDermott R: Metastatic phyllodes tumor causing small-bowel obstruction. Clin Breast Cancer; 2009 Aug;9(3):193-5
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  • [Title] Metastatic phyllodes tumor causing small-bowel obstruction.
  • Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas.
  • Metastases to the small intestine are extremely rare, with only 1 case of metastatic spread to the duodenum reported in the literature.
  • This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction.
  • Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems.
  • The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Ileal Neoplasms / secondary. Intestinal Obstruction / etiology. Phyllodes Tumor / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19661046.001).
  • [ISSN] 1938-0666
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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30. Papalambros A, Petrou A, Brennan N, Bramis K, Felekouras E, Papalambros E: GIST suture-line recurrence at a gastrojejunal anastomosis 8 years after gastrectomy: can GIST ever be described as truly benign? A case report. World J Surg Oncol; 2010;8:90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] GIST suture-line recurrence at a gastrojejunal anastomosis 8 years after gastrectomy: can GIST ever be described as truly benign? A case report.
  • We present the case of a 71 year old man with recurrence of a Gastro Intestinal Stromal Tumour (GIST) at the gastrojejunal anastomosis eight years following partial gastrectomy for a very small primary gastric GIST.
  • The histopathology was in keeping with a diagnosis of a gastric GIST with a <2 cm tumour, with <5 mitosis per 50/HPF, no signs of necrosis and invasion limited to the mucosa.
  • He subsequently underwent completion gastrectomy and the histology revealed a 0.8 cm GIST tumour composed of spindle cells with <5 mitosis per 50/HPF, tumor invasion into the submucosa and positive expression of c-kit and SMA.
  • The literature suggests that tumour size, mitotic rate and tumour site are the most important predictive factors of recurrence.
  • Additional features such as the presence of necrosis, local tumour invasion and positive resection margins, can also influence recurrence rates.
  • In this case the lesion was a gastric GIST, very small (<2 cm), had low proliferation rate (<5 mitosis/HPF), lacked necrosis and was limited to the mucosa.
  • This case highlights how even the most innocent GISTs can never be described as truly benign.
  • [MeSH-major] Gastrectomy / methods. Gastrointestinal Stromal Tumors / surgery. Jejunum / surgery. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Stomach / surgery. Stomach Neoplasms / surgery

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  • [Cites] J Natl Compr Canc Netw. 2010 Apr;8 Suppl 2:S1-41; quiz S42-4 [20457867.001]
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  • (PMID = 20946677.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2965163
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31. Levin TG, Powell AE, Davies PS, Silk AD, Dismuke AD, Anderson EC, Swain JR, Wong MH: Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology; 2010 Dec;139(6):2072-2082.e5
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  • [Title] Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract.
  • BACKGROUND & AIMS: CD166 (also called activated leukocyte cell adhesion molecule [ALCAM]) is a marker of colorectal cancer (CRC) stem cells; it is expressed by aggressive tumors.
  • Although the presence of CD166 at the tumor cell surface has been correlated with shortened survival, little is known about its function and expression in normal intestinal epithelia.
  • METHODS: We characterized the expression pattern of CD166 in normal intestinal tissue samples from humans and mice using immunohistochemisty, flow cytometry, and quantitative reverse-transcriptase polymerase chain reaction.
  • Human and mouse intestinal tumors were also analyzed.
  • RESULTS: CD166 was expressed on the surface of epithelial cells within the stem cell niche and along the length of the intestine; expression was conserved across species.
  • In the small intestine, CD166 was observed on crypt-based Paneth cells and intervening crypt-based columnar cells (putative stem cells).
  • CD166 was located in the cytoplasm and at the surface of cells within human CRC tumors.
  • CD166-positive cells were also detected in benign adenomas in mice; rare cells coexpressed CD166 and CD44 or epithelial-specific antigen.
  • CONCLUSIONS: CD166 is highly expressed within the endogenous intestinal stem cell niche.
  • CD166-positive cells appear at multiple stages of intestinal carcinoma progression, including benign and metastatic tumors.
  • Further studies should investigate the function of CD166 in stem cells and the stem cell niche, which might have implications for normal intestinal homeostasis.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20826154.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA118235; United States / NIDDK NIH HHS / DK / U01 DK085525-02; United States / NHLBI NIH HHS / HL / T32 HL007781; United States / NCI NIH HHS / CA / CA106195-06A1; United States / NCI NIH HHS / CA / CA118235-05; United States / NICHD NIH HHS / HD / T32 HD049309-05; United States / NCI NIH HHS / CA / CA106195; United States / NCI NIH HHS / CA / T32 CA106195; United States / NICHD NIH HHS / HD / HD049309; United States / NICHD NIH HHS / HD / T32 HD049309; United States / NCI NIH HHS / CA / T32 CA106195-06A1; United States / NHLBI NIH HHS / HL / T32 HL007781-14; United States / NIDDK NIH HHS / DK / R01 DK068326; United States / NCI NIH HHS / CA / CA118235; United States / NIDDK NIH HHS / DK / R01 DK068326-05; United States / NIDDK NIH HHS / DK / DK068326; United States / NIDDK NIH HHS / DK / DK085525-02; United States / NICHD NIH HHS / HD / HD049309-05; United States / NHLBI NIH HHS / HL / HL007781-14; United States / NHLBI NIH HHS / HL / HL007781; United States / NIDDK NIH HHS / DK / U01 DK085525; United States / NIDDK NIH HHS / DK / DK085525; United States / NIDDK NIH HHS / DK / DK068326-05; United States / NCI NIH HHS / CA / R01 CA118235-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALCAM protein, human; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules, Neuronal; 0 / Fetal Proteins
  • [Other-IDs] NLM/ NIHMS234467; NLM/ PMC2997177
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32. Ba MC, Qing SH, Huang XC, Wen Y, Li GX, Yu J: Application of laparoscopy in diagnosis and treatment of massive small intestinal bleeding: report of 22 cases. World J Gastroenterol; 2006 Nov 21;12(43):7051-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Application of laparoscopy in diagnosis and treatment of massive small intestinal bleeding: report of 22 cases.
  • AIM: To investigate the diagnostic and therapeutic value of laparoscopy in patients with massive small intestinal bleeding.
  • METHODS: Twenty-two patients with massive small intestinal bleeding and hemodynamic alteration underwent laparoscopic laparotomy in our unit from December 2002 to April 2005.
  • Post pathologic sites were found, laparoscopy- or laparoscopy-assisted part small intestinal resection including pathologic intestinal site and enteroanastomosis was performed in all these patients.
  • Massive small intestinal bleeding was caused by jejunum benign stromal tumor in 8 cases, by jejunum potential malignant stromal tumor in 5 cases, by jejunum malignant stromal tumor in 1 case, by Mechel's diverticulum in 5 cases, by small intestinal vascular deformity in 2 cases, and by ectopic pancreas in 1 case.
  • A total of 16 patients underwent laparoscopy-assisted enterectomy and enteroanastomosis of small intestine covering the diseased segment and 6 patients received enterectomy of the diseased segment under laparoscope.
  • CONCLUSION: Laparoscopy in diagnosis and treatment of massive small intestinal bleeding is noninvasive with less pain, short recovery time and definite therapeutic efficacy.
  • [MeSH-major] Anastomosis, Surgical / methods. Gastrointestinal Hemorrhage / diagnosis. Gastrointestinal Hemorrhage / surgery. Intestinal Diseases / diagnosis. Intestinal Diseases / surgery. Intestine, Small / surgery. Laparoscopy / methods

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  • (PMID = 17109505.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087354
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33. Pavageau AH, Valo I, Lavoine E, Bourgois JL, Verrièle V: [Inflammatory fibroid polyp: a report of three cases including an oesophageal tumor]. Ann Pathol; 2009 Dec;29(6):499-503
MedlinePlus Health Information. consumer health - Esophageal Cancer.

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  • [Title] [Inflammatory fibroid polyp: a report of three cases including an oesophageal tumor].
  • On microscopic examination, the tumor consisted of spindle cell dispersed in a loose fibromyxoid stroma containing numerous blood vessels and inflammatory cells with abundant eosinophils.
  • Inflammatory fibroid polyp is a rare benign lesion of the gastro-intestinal tract.
  • Diagnosis on biopsy is difficult with various histologic pattern and because the inflammatory fibroid polyp share common pathologic features with digestive spindle cells tumor.
  • [MeSH-major] Esophageal Neoplasms / pathology. Intestinal Polyps / pathology. Leiomyoma / pathology
  • [MeSH-minor] Cell Division. Connective Tissue / pathology. Edema / pathology. Eosinophils / pathology. Female. Humans. Inflammation / pathology. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Male. Middle Aged. Polyploidy

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  • (PMID = 20005440.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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34. Bogner B, Péter S, Hegedus G: [Inflammatory fibroid polyp of the ileum causing intestinal invagination]. Magy Seb; 2005 Aug;58(4):237-40
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  • [Title] [Inflammatory fibroid polyp of the ileum causing intestinal invagination].
  • Inflammatory fibroid polyps are rare benign tumor-like lesions of the gastrointestinal tract.
  • Most frequently they are localized in the gastric antrum but can develop anywhere in the GI tract.
  • In the small intestine the ileum is the most common site, where these polyps can cause invagination and intussusception.
  • [MeSH-major] Fibroma / complications. Ileal Neoplasms / complications. Intestinal Polyps / complications. Intussusception / etiology

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  • (PMID = 16261870.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 13
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35. Zhang K, Aruva MR, Shanthly N, Cardi CA, Patel CA, Rattan S, Cesarone G, Wickstrom E, Thakur ML: Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation. Regul Pept; 2007 Dec 4;144(1-3):91-100
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation.
  • Vasoactive intestinal peptide and pituitary adenylate cyclase activating peptide have high affinity for VPAC1, VPAC2 and PAC1 receptors overexpressed on human cancer cells.
  • RT-PCR confirmed increased VPAC1 receptor expression on human breast tumor cells over normal cells and corroborated with autoradiography data.
  • Data demonstrate that these analogues are potent, have uncompromised biological activity and are worthy of further evaluation for accurate PET imaging of human breast cancers and in determining malignant and benign lesions.

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  • (PMID = 17727979.001).
  • [ISSN] 0167-0115
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA109231-02; United States / NCI NIH HHS / CA / R01 CA109231-03; United States / NCI NIH HHS / CA / R01 CA109231; United States / NCI NIH HHS / CA / R01 CA109231-01A1; United States / NCI NIH HHS / CA / R01 CA109231-02; United States / NCI NIH HHS / CA / CA109231-03; United States / NCI NIH HHS / CA / CA-109231; United States / NCI NIH HHS / CA / CA109231-01A1
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Copper Radioisotopes; 0 / Peptides; 0 / Pituitary Adenylate Cyclase-Activating Polypeptide; 0 / Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; 0 / Receptors, Vasoactive Intestinal Peptide; 37221-79-7 / Vasoactive Intestinal Peptide
  • [Other-IDs] NLM/ NIHMS34687; NLM/ PMC2587158
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36. Chatelain D, Brevet M, Fuks D, Yzet T, Verhaeghe P, Regimbeau JM, Lauwers G, Sevestre H: [Inflammatory fibroid polyp, a rare tumor of the appendix]. Gastroenterol Clin Biol; 2008 Mar;32(3):274-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [Title] [Inflammatory fibroid polyp, a rare tumor of the appendix].
  • On microscopic examination, the tumor consisted of spindle cells dispersed in a loose fibromyxoid stroma containing numerous blood cells and inflammatory cells with abundant eosinophils.
  • On immunohistochemistry, the spindle tumor cells were positive for vimentin, fascin and focally for CD34 and CD35.
  • Inflammatory fibroid polyp is a rare benign mesenchymal tumor of the gastrointestinal tract rarely reported in the appendix.
  • This tumor shares some common pathologic features with the myofibroblatic inflammatory tumor but they are two different entities.
  • The pathogenesis of this tumor remains unclear but fascin and CD35 immunoreactivity of the tumor cells suggests a probable dendritic cell origin.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Intestinal Polyps / pathology. Leiomyoma / pathology

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  • (PMID = 18353580.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / CR1 protein, human; 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / Receptors, Complement 3b; 0 / Vimentin; 146808-54-0 / fascin
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37. Pulitzer M, Xu R, Suriawinata AA, Waye JD, Harpaz N: Microcarcinoids in large intestinal adenomas. Am J Surg Pathol; 2006 Dec;30(12):1531-6
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  • [Title] Microcarcinoids in large intestinal adenomas.
  • Composite adenoma-carcinoid tumors are rare colorectal lesions consisting of intermingled adenomatous and carcinoid components.
  • Unlike other mixed endocrine-glandular colorectal neoplasms, which are generally malignant, their glandular component is histologically benign and their natural history is favorable.
  • The patients' clinical course was benign on the basis of 2 years' median follow-up (range, 6 mo to 10 y).
  • Two patients with incomplete polypectomies underwent hemicolectomy revealing no residual endocrine neoplasia.
  • Awareness of microcarcinoids in colonic adenomas should help avert potential diagnostic pitfalls posed by their pleomorphism, basal location, and infiltrative patterns, and may help clarify their natural history and possible relationship to composite glandular-carcinoid tumors.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Intestinal Neoplasms / pathology. Intestine, Large / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Female. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 17122508.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Yang Y, Nie X, Lu J, Lu XY, Wei YY, Wang H, Han ZH, Chen ZH, Zheng J: [Mixed epithelial and stromal tumor of kidney]. Zhonghua Bing Li Xue Za Zhi; 2006 Jan;35(1):29-31
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mixed epithelial and stromal tumor of kidney].
  • OBJECTIVE: To study the clinicopathological features and differential diagnoses of mixed epithelial and stromal tumor of the kidney.
  • METHODS: Clinical and pathological characteristics of 4 cases of mixed epithelial and stromal tumor of the kidney were studied.
  • Grossly the tumors had a solid and cyst appearance.
  • Microscopically, the tumors were composed of a mixture of stromal and epithelial elements.
  • One case showed Müllerian and intestinal epithelial differentiations.
  • Stromal elements essentially consisted of spindle cells, with thick-walled blood vessels and bands of smooth muscle cells as distinctive features of the tumor.
  • CONCLUSIONS: Mixed epithelial and stromal tumor of the kidney is a benign neoplasm with distinct histopathological features.
  • It should be distinguished from many other renal neoplasms.
  • [MeSH-major] Kidney Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • (PMID = 16608646.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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39. Khoury T, Chadha K, Javle M, Donohue K, Levea C, Iyer R, Okada H, Nagase H, Tan D: Expression of intestinal trefoil factor (TFF-3) in hepatocellular carcinoma. Int J Gastrointest Cancer; 2005;35(3):171-7
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  • [Title] Expression of intestinal trefoil factor (TFF-3) in hepatocellular carcinoma.
  • BACKGROUND: Trefoil peptides (TFF-1, 2, 3) are a family of protease-resistant regulatory factors that play a role in mucosal restitution, angiogenesis, apoptosis, and tumor progression.
  • Intestinal trefoil peptide (TFF-3) expression has been demonstrated in benign hepatobiliary diseases, but there are limited data regarding its expression in HCC.
  • Tumor/ normal tissue interface was assessable in 21 cases; 11 cases expressed TFF-3 at the interface.
  • There was a strong correlation between tumor grade and TFF-3 expression, wherein poorly differentiated tumors had moderate/strong TFF-3 expression (p = 0.008).
  • CONCLUSION: TFF-3 is commonly expressed in HCC and its expression correlates with tumor grade.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Liver Neoplasms / metabolism. Peptides / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Analysis

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  • (PMID = 16110118.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides; 146046-78-8 / trefoil factor
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40. Shah SN: Malignant gastrointestinal stromal tumor of intestine: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):357-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant gastrointestinal stromal tumor of intestine: a case report.
  • Smooth muscle tumors of the alimentary tract are uncommon.
  • Cancer of small intestine comprises less than 20% of all malignant tumors.
  • He was diagnosed as a case of acute intestinal obstruction and on laparotomy an extraluminal mass was found at jejunoileal junction.
  • Histopathology revealed a malignant gastrointestinal stromal tumor (GIST) which was confirmed by immunohistochemistry.
  • The case is reported with review of literature and criteria for differentiation between benign and malignant tumors are enumerated.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology. Intestinal Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology. Male

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  • (PMID = 17883072.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 13
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41. Zuccarello C, Arena F, Fazzari C, Arena S, Nicòtina PA: Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature. Minerva Pediatr; 2006 Oct;58(5):495-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature.
  • Inflammatory myofibroblastic tumor (IMT) of the ileum is a rare, usually solitary lesion, that frequently presents small-intestinal intussusception and obstruction.
  • We describe an IMT of the ileum in a 4.5-year old child who presented a small bowel intussusception.
  • Three months after the operation, the patients were hospitalized with the symptoms of intestinal obstruction.
  • Along the previous suture line of anastomosis, a smooth polypoid tumor was evident.
  • Segmental resection of the ileum, including the tumor mass, was performed.
  • A review of the literature for this rare entity emphasizes the importance of immunohistochemical confirmation of its benign nature.
  • [MeSH-major] Ileal Diseases / etiology. Ileal Neoplasms / complications. Intussusception / etiology. Neoplasm Recurrence, Local / complications

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  • (PMID = 17008862.001).
  • [ISSN] 0026-4946
  • [Journal-full-title] Minerva pediatrica
  • [ISO-abbreviation] Minerva Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 17
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42. Garneau H, Paquin MC, Carrier JC, Rivard N: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. J Cell Physiol; 2009 Nov;221(2):350-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells.
  • The generation of knock-out mice for E2F4 gene expression has suggested a role for this transcription factor in establishing and/or maintaining the intestinal crypt compartment.
  • Having previously demonstrated that E2F4 is cytoplasmic in quiescent-differentiated cells but nuclear in growth factor-stimulated proliferative cells, the present study was aimed at determining the role of E2F4 in the control of human intestinal epithelial proliferation.
  • Results herein demonstrate that lentiviral infection of an shRNA which specifically knocked-down E2F4 expression slowed down G1/S phase transition and the proliferation rate of normal human intestinal epithelial cells (HIEC) and of colon cancer cells.
  • Immunofluorescence experiments in human fetal intestine revealed that cells expressing high nuclear levels of E2F4 also expressed cyclin A protein.
  • Lastly, E2F4 and its target cyclin A were up-regulated and mostly nuclear in human colorectal tumor cells in comparison to the corresponding benign epithelium.
  • These results indicate that nuclear E2F4 may be determinant in the promotion of proliferation of human intestinal epithelial crypt cells and colorectal cancer cells.
  • [MeSH-major] Cell Cycle. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. E2F4 Transcription Factor / metabolism. Intestines / cytology. Intestines / metabolism
  • [MeSH-minor] Agar. Cell Line, Tumor. Cell Nucleus / metabolism. Cell Proliferation. Cyclin A / metabolism. DNA / biosynthesis. Down-Regulation. Epithelial Cells / cytology. Epithelial Cells / metabolism. G1 Phase. Gene Expression Regulation, Neoplastic. Gene Knockdown Techniques. Humans. Protein Transport. S Phase

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  • (PMID = 19562678.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / E2F4 Transcription Factor; 0 / E2F4 protein, human; 9002-18-0 / Agar; 9007-49-2 / DNA
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43. Van Kerkhóve F, Coenegrachts K, Steyaert L, Van Den Berghe I, Casselman JW: Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor. JBR-BTR; 2006 Sep-Oct;89(5):258-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor.
  • We present a case of a rare small bowel tumor.
  • Ultrasound examination discovered an inhomogeneous vascularised mass originating from a small bowel loop, mesenteric enlarged lymph nodes and a nodule in the liver.
  • Pathology revealed a rare ileal collision tumor consisting of an adenocarcinoma and a small cell neuroendocrine tumor with peritoneal metastasis of neuroendocrine origin and coincidental benign lesions on both ovaries.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Adenomatous Polyps / diagnosis. Carcinoma, Small Cell / diagnosis. Ileal Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Tomography, X-Ray Computed. Ultrasonography
  • [MeSH-minor] Adenofibroma / diagnosis. Adenofibroma / pathology. Adenofibroma / surgery. Aged. Cystadenoma / diagnosis. Cystadenoma / pathology. Cystadenoma / surgery. Female. Fibroma / diagnosis. Fibroma / pathology. Fibroma / surgery. Humans. Ileum / pathology. Ileum / surgery. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Liver / pathology. Liver / surgery. Lymphatic Metastasis / pathology. Mesentery / pathology. Mesentery / surgery. Omentum / pathology. Omentum / surgery. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Ovariectomy. Ovary / pathology. Peritoneum / pathology. Peritoneum / surgery

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  • (PMID = 17147014.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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44. Yu YH, Son BK, Jun DW, Kim SH, Jo YJ, Park YS, Hong BW, Joo JE: [A case of desmoid tumor presenting as intra-abdominal abscess]. Korean J Gastroenterol; 2009 May;53(5):315-9
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  • [Title] [A case of desmoid tumor presenting as intra-abdominal abscess].
  • Desmoid tumor is a rare benign tumor derived from fibrous sheath or musculoaponeurotic structure.
  • The tumor is benign histologically but considered as malignant clinically because it has high propensity on infiltrative growth with local invasion and tendency to recurrence after local excision.
  • Especially, when this tumor happens to be in the intra-abdomen, the prognosis is worse because it can cause intestinal obstruction, ureter obstruction and, fistula formation.
  • This tumor occurs more frequently in patients with familial adenomatous polyposis (FAP), in post-partume women, and at old surgical incision site.
  • We report a rare case of the young male patient who presented with an acute abdomen and underwent laparotomy and was found to have an intra-abdominal desmoid tumor with abscess formation.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Peritoneal Neoplasms / diagnosis

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  • (PMID = 19458469.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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45. Nishihara E, Miyauchi A, Hirokawa M, Kudo T, Ohye H, Ito M, Kubota S, Fukata S, Amino N, Kuma K: Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature. Endocrine; 2006 Oct;30(2):231-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature.
  • Benign thyroid teratomas are rare in adolescents and adults.
  • We report on three cases of benign thyroid teratomas that presented as painful tumors in the neck after puberty.
  • The tumor adjacent to the thyroid in each case showed rapid enlargement with predominant cystic lesions within several months.
  • Ultrasonography and computed tomography revealed few findings suggesting the origin of the tumor.
  • Cytological examination and culture of the aspirate failed to show cells originating from the thyroid or infectious findings, but revealed a small population of columnar epithelial cells or squamous epithelial cells.
  • The patients subsequently underwent resection of the tumor, and microscopic examination revealed various types of tissue including pancreas, adipose, cartilage, muscle, and skin, and the cystic wall was lined by gastric, intestinal, respiratory, and stratified squamous epithelium.
  • Surgical resection was curative, and subsequent histologic examination revealed mature benign teratomas of the thyroid.
  • The main characteristic of our cases presented the painful tumors due to the enlarged cystic formation lined by a variety of different types of epithelium, which agreed with previous cases of benign thyroid teratomas in adolescents and adults.
  • [MeSH-major] Pain / diagnosis. Teratoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasms / diagnosis

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  • (PMID = 17322585.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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46. Hedlund TE, van Bokhoven A, Johannes WU, Nordeen SK, Ogden LG: Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. Prostate; 2006 Apr 1;66(5):557-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro.
  • BACKGROUND: The differential intestinal metabolism of the soy isoflavones is likely to influence the ability of soy to prevent prostate cancer.
  • METHODS: The effects of isoflavonoids on cell growth, cell cycle distribution, and apoptosis (active Caspase 3) were examined on benign prostatic epithelial cells (PrEC), and the prostate cancer cell line LNCaP.
  • [MeSH-major] Cell Division / drug effects. Isoflavones / metabolism. Prostate / cytology. Prostatic Neoplasms / pathology. Soybean Proteins
  • [MeSH-minor] Cell Line, Tumor. Diet. Humans. Male

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16372328.001).
  • [ISSN] 0270-4137
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoflavones; 0 / Soybean Proteins
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47. Siablis D, Papathanassiou ZG, Karnabatidis D, Christeas N, Vagianos C: Hemobilia secondary to hepatic artery pseudoaneurysm: an unusual complication of bile leakage in a patient with a history of a resected IIIb Klatskin tumor. World J Gastroenterol; 2005 Sep 7;11(33):5229-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemobilia secondary to hepatic artery pseudoaneurysm: an unusual complication of bile leakage in a patient with a history of a resected IIIb Klatskin tumor.
  • We report a case of a 74-year-old woman with a 16-year history of a double bilo-enteric anastomosis due to resected hilar cholangiocarcinoma (Type IIIb Klatskin tumor).
  • The patient presented with cholangitis secondary to benign anastomotic stenosis which resulted in a large intrahepatic biloma.
  • Anastomotic patency was achieved, complicated, however, by persistent upper gastro-intestinal bleeding, presented as hemobilia.
  • This had ruptured into the biliary tract, and presented the actual cause of the hemobilia.
  • [MeSH-major] Aneurysm, False / complications. Bile / metabolism. Bile Duct Neoplasms / surgery. Hemobilia / etiology. Hepatic Artery. Hepatic Duct, Common. Klatskin Tumor / surgery. Postoperative Complications

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  • (PMID = 16127759.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320402
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48. Chang WC, Sheu BC, Lin MC, Chow SN, Huang SC: Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report. Int J Gynecol Cancer; 2005 May-Jun;15(3):549-53
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report.
  • Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms.
  • Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy.
  • Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were performed, and the frozen pathology during operation showed mucinous tumor of borderline malignancy of left ovary on April 18, 2002.
  • It is difficult to determine whether intestinal-type borderline mucinous tumors with intraepithelial carcinoma are associated with a worse prognosis compared with those with epithelial atypia alone due to disparate results in the published literature.
  • However, too few cases of carcinosarcoma-like mural nodule in mucinous tumor have been published to warrant a conclusion regarding their prognosis.
  • [MeSH-major] Carcinosarcoma / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Prognosis

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  • (PMID = 15882184.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Fingleton B, Carter KJ, Matrisian LM: Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res; 2007 May 15;67(10):4800-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model.
  • Fas ligand (FasL/CD95L), a member of the tumor necrosis factor family, interacts with a specific receptor Fas, ultimately leading to cell death.
  • Tumor expression of FasL has been proposed to aid in immune evasion through a "Fas counterattack" mechanism but has also been described as a proinflammatory factor.
  • Here, we tested the role of FasL in a mouse model of spontaneous tumor development.
  • We used the Min mouse in which multiple benign polyps develop in the intestine due to a mutation in the Apc tumor suppressor gene.
  • Mutant mice deficient in functional FasL, termed gld/gld, were crossed to Min mice to generate tumor-prone animals lacking functional FasL.
  • There was no difference in the number of either lymphocytes or macrophages; however, the number of tumor-infiltrating neutrophils was 3-fold lower in the gld/gld specimens compared with controls.
  • In a nontumor-bearing colitis model in vivo, neutrophil recruitment to the intestine was also reduced in gld/gld mice.
  • Although the Fas counterattack hypothesis suggests that the absence of FasL would result in increased immune-mediated tumor elimination, the opposite is true in the Min model with lack of functional FasL associated with reduced neutrophil influx and increased tumor development.
  • Thus, the proinflammatory rather than counterattack role of tumor FasL is more relevant.
  • [MeSH-major] Cell Transformation, Neoplastic / immunology. Fas Ligand Protein / immunology. Intestinal Neoplasms / immunology
  • [MeSH-minor] Adenoma / genetics. Adenoma / immunology. Adenoma / pathology. Animals. Cell Movement / immunology. Disease Models, Animal. Genes, APC. Humans. Inflammation / immunology. Inflammation / pathology. Intestinal Polyps / genetics. Intestinal Polyps / immunology. Intestinal Polyps / pathology. Lymphocytes / immunology. Male. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Mutation

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  • (PMID = 17510409.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA60867
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fas Ligand Protein
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50. Hashimoto N, Hakamada K, Narumi S, Totsuka E, Aoki K, Kamata Y, Sasaki M: Heterotopic gastrointestinal mucosa and pancreatic tissue in a retroperitoneal tumor. J Hepatobiliary Pancreat Surg; 2006;13(4):351-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Heterotopic gastrointestinal mucosa and pancreatic tissue in a retroperitoneal tumor.
  • We believe that this is the first report of a retroperitoneal tumor consisting of heterotopic gastrointestinal mucosa and pancreatic tissue.
  • Angiography revealed that the inferior vena cava was displaced by the hypovascular tumor.
  • The retroperitoneal lesion was diagnosed preoperatively as a benign tumor such as a neurogenic neoplasm or lymphangioma.
  • At laparotomy, a cystic tumor was found, which existed behind the inferior vena cava and renal vessels, and contained reddish-brown fluid, suggesting hemorrhage in the past.
  • The cut surface of the tumor showed a unilocular cyst with partially hypertrophic wall.
  • Histopathological examination revealed a cystic tumor lined with heterotopic gastric and duodenal mucosa, with pancreatic tissue in the muscularis propria.
  • In addition, evidence of bleeding from the gastric mucosa was observed in the cystic tumor.
  • External secretion from these tissues could have triggered the hemorrhage and expanded the tumor, possibly resulting in the back pain.
  • [MeSH-major] Back Pain / etiology. Choristoma / pathology. Gastric Mucosa. Intestinal Mucosa. Retroperitoneal Neoplasms / pathology. Vascular Neoplasms / pathology

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  • (PMID = 16858549.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Hornick JL, Fletcher CD: Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol; 2005 Jul;29(7):859-65
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  • [Title] Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.
  • Benign peripheral nerve sheath tumors are uncommon in the gastrointestinal tract, and perineuriomas have not previously been reported to occur at this anatomic location.
  • In this study, we analyzed the clinicopathologic and immunohistochemical features of 10 perineuriomas arising in the intestine.
  • Eight of the lesions were intramucosal perineuriomas presenting as small sessile polyps detected during colonoscopy; 6 of these 8 patients were asymptomatic and undergoing colorectal cancer screening.
  • The colonic submucosal tumor was microscopically well circumscribed, whereas the jejunal perineurioma showed focal infiltration through the muscularis propria into the subserosa.
  • The stroma was collagenous in the colonic tumor and predominantly myxoid in the jejunal tumor.
  • All tumors except one were positive for epithelial membrane antigen (EMA); 4 of 10 expressed claudin-1 and 2 of 10 expressed CD34.
  • All tumors were negative for S-100 protein, glial fibrillary acidic protein, neurofilament protein, smooth muscle actin, desmin, caldesmon, KIT, and pan-keratin.
  • Electron microscopy was performed on the tumor lacking EMA expression, revealing typical features of perineurioma, namely, spindle cells with long bipolar cytoplasmic processes and prominent pinocytotic vesicles, surrounded by discontinuous basal lamina.
  • No tumor recurred.
  • In summary, perineuriomas may arise in the intestine, most often as intramucosal lesions detected as colorectal polyps with distinctive histologic features including entrapment of colonic crypts.
  • Distinguishing perineuriomas from other spindle cell neoplasms of the gastrointestinal tract can be facilitated by immunostaining for EMA and claudin-1.
  • [MeSH-major] Intestinal Neoplasms / pathology. Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2006 Oct;30(10):1337-9 [17001168.001]
  • (PMID = 15958849.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 26
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52. Ozolek JA, Barnes EL, Hunt JL: Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study. Arch Pathol Lab Med; 2007 Apr;131(4):530-7
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  • [Title] Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study.
  • The immunophenotype of the basal/myoepithelial layer has not been fully examined in benign glandular lesions of the sinonasal tract.
  • OBJECTIVE: To examine benign and malignant glandular lesions in the sinonasal tract for the immunophenotype of basal/myoepithelial cells, proliferation index, and cytokeratin and intestinal differentiation profiles.
  • DESIGN: Sinonasal adenocarcinoma (intestinal-type adenocarcinoma [ITAC] and nonintestinal type adenocarcinoma [non-ITAC]), REAH, IP, and chronic sinusitis (CS) were stained for cytokeratin (CK) 7, CK20, 34betaE12, CDX-2, p63, Ki-67, smooth muscle actin (SMA), S100 protein, and calponin.
  • In benign lesions, proliferative activity is limited to the compartments with p63 staining.
  • [MeSH-major] Adenocarcinoma / pathology. Hamartoma / pathology. Keratins / metabolism. Papilloma / pathology. Paranasal Sinus Neoplasms / pathology. Sinusitis / pathology
  • [MeSH-minor] Actins / metabolism. Biomarkers, Tumor / analysis. Calcium-Binding Proteins / metabolism. Cell Proliferation. Chronic Disease. Diagnosis, Differential. Epithelial Cells / pathology. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Immunophenotyping. Ki-67 Antigen / metabolism. Male. Membrane Proteins / metabolism. Microfilament Proteins / metabolism. Middle Aged. S100 Proteins / metabolism. Trans-Activators / metabolism

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  • (PMID = 17425380.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / S100 Proteins; 0 / Trans-Activators; 0 / calponin; 156560-97-3 / Cdx-2-3 protein; 68238-35-7 / Keratins
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53. Coco C, Rizzo G, Manno A, Mattana C, Verbo A: Surgical treatment of small bowel neoplasms. Eur Rev Med Pharmacol Sci; 2010 Apr;14(4):327-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of small bowel neoplasms.
  • Small intestinal neoplasms are uncommon cancers.
  • Benign small intestinal tumors (e.g., leiomyoma, lipoma, hamartoma, or desmoid tumor) usually are asymptomatic but may present with complications.
  • Primary malignancies of the small intestine, including adenocarcinoma, leiomyosarcoma, carcinoid, and lymphoma, are often symptomatic and may present with intestinal obstruction, jaundice, bleeding, or pain.
  • Metastatic neoplasms may involve the small intestine via contiguous spread, peritoneal metastases or hematogenous metastases.
  • Because the small intestine is relatively inaccessible to routine endoscopy, diagnosis of small intestinal neoplasms is often delayed for months after onset of symptoms.
  • During last years the increase of small bowel endoscopy and other diagnostic tools allow earlier non-operative diagnosis.
  • Even though radical resection of small bowel cancer plays an important role, the 5 yr overall survival remains low.
  • [MeSH-major] Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery. Humans. Laparoscopy. Lymphoma / pathology. Lymphoma / surgery. Neoplasm Metastasis

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  • (PMID = 20496543.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 51
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54. Singhi AD, Montgomery EA: Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol; 2010 Aug;34(8):1186-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colorectal granular cell tumor: a clinicopathologic study of 26 cases.
  • Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA).
  • Most neoplasms were encountered on routine colonoscopy (14/24, 64%), however 3 patients presented with hematochezia, 3 with changing bowel habits, 2 with Crohn disease, 1 with diverticular disease, and 1 with appendicitis.
  • Of the 20 cases available for histologic review, the tumors were noted to either be infiltrative (12/20, 60%) or marginated (8/20, 40%) involving either the mucosa (7/20, 35%), submucosa (10/20, 50%), or both (3/20, 15%).
  • The microscopic features were similar to those of GCTs found elsewhere, but many of the neoplasms differed by displaying nuclear pleomorphism (8/20, 40%), lymphoid cuffs (9/20, 45%), and focal calcification (7/20, 35%).
  • On immunochemistry, 18 of the neoplasms were stained for S-100 and all cases showed positive staining.
  • Although GCTs were benign tumors in this series, if incompletely excised regrowth of the lesion may occur and therefore, follow-up may be warranted.
  • [MeSH-major] Adenocarcinoma / pathology. Colon / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Colectomy. Colonoscopy. Female. Humans. Immunohistochemistry. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. S100 Proteins / analysis

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  • (PMID = 20661017.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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55. Falguières T, Maak M, von Weyhern C, Sarr M, Sastre X, Poupon MF, Robine S, Johannes L, Janssen KP: Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool. Mol Cancer Ther; 2008 Aug;7(8):2498-508
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool.
  • The targeting of solid tumors requires delivery tools that resist intracellular and extracellular inactivation, and that are taken up specifically by tumor cells.
  • We have shown previously that the recombinant nontoxic B-subunit of Shiga toxin (STxB) can serve as a delivery tool to target digestive tumors in animal models.
  • Tissue samples of normal colon, benign adenomas, colorectal carcinomas, and liver metastases from 111 patients were obtained for the quantification of the expression of the cellular STxB receptor, the glycosphingolipid globotriaosyl ceramide (Gb(3) or CD77).
  • We found that compared with normal tissue, the expression of Gb(3) was strongly increased in colorectal adenocarcinomas and their metastases, but not in benign adenomas.
  • Of a given tumor sample, on average, 80% of the cells could visibly bind STxB, and upon incubation at 37 degrees C, STxB was transported to the Golgi apparatus, following the retrograde route.
  • This STxB-specific intracellular targeting allows the molecule to avoid recycling and degradation, and STxB could consequently be detected on tumor cells even 5 days after initial uptake.
  • In conclusion, the targeting properties of STxB could be diverted for the delivery of contrast agents to human colorectal tumors and their metastases, whose early detection and specific targeting remains one of the principal challenges in oncology.
  • [MeSH-major] Antigens, Tumor-Associated, Carbohydrate / biosynthesis. Colorectal Neoplasms / therapy. Intestines / microbiology. Shiga Toxins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromatography, Thin Layer. Female. Humans. Liver Neoplasms / metabolism. Liver Neoplasms / secondary. Male. Middle Aged. Trihexosylceramides / biosynthesis

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  • (PMID = 18687997.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Gb3 antigen; 0 / Shiga Toxins; 0 / Trihexosylceramides; 0 / stxB toxin; 71965-57-6 / globotriaosylceramide
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56. Bara T, Bancu S, Bara T Jr, Mureşan M, Bancu L, Azamfirei L, Podeanu D, Mureşan S: [Gastric stromal tumor with liver and subcutaneus metastasis. Case report]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):621-4
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  • [Title] [Gastric stromal tumor with liver and subcutaneus metastasis. Case report].
  • The gastrointestinal stromal tumours expand from the undefine mezenchimal cells of the intestinal wall and the origin is in the Cajal interstitial cells.
  • Very importants factors for grading are the tumour localisation, the invasion of serosa or mucosa, the dimensions of tumour and the number of mytosis.
  • We present a case with haemoragic gastric stromal tumour, with small dimensions, which was initially diagnosed as a "benign" tumour.
  • CONCLUSIONS: The gastrointestinals stromal tumours represent a very rare group of digestive tract tumors, with malignant potentially evolution; the first choice of treatment is surgery, with complete ablation of the tumour.
  • [MeSH-major] Gastrointestinal Stromal Tumors / secondary. Liver Neoplasms / secondary. Soft Tissue Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19943565.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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57. Kara C, Kutlu AO, Tosun MS, Apaydin S, Senel F: Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. Horm Res; 2005;63(5):252-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by benign intestinal hamartomatous polyps and mucocutaneous pigmentation, and with an increased risk for intestinal and extra-intestinal neoplasms.
  • Sertoli cell tumors in boys with PJS have been increasingly recognized as a cause of prepubertal gynecomastia.
  • We report on a 7.25-year-old boy with PJS, bilateral gynecomastia, Sertoli cell tumor and nephrocalcinosis, and present the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • Histopathological examination was consistent with Sertoli cell tumors.
  • [MeSH-major] Aromatase Inhibitors / therapeutic use. Gynecomastia / complications. Peutz-Jeghers Syndrome / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testolactone / therapeutic use

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  • (PMID = 15947469.001).
  • [ISSN] 0301-0163
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 6J9BLA949Q / Testolactone
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58. Lasota J, Wang ZF, Sobin LH, Miettinen M: Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases. Mod Pathol; 2009 Aug;22(8):1049-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases.
  • The inflammatory fibroid polyp is a rare benign lesion occurring throughout the digestive tract.
  • In this study, PDGFRA exons 12, 14, and 18 were screened for activating mutations in 60 small intestinal inflammatory fibroid polyps.
  • However, 1835_1852delinsCGC leading to the same S566_E571delinsR, were found in two tumors.
  • Similar gain-of-function PDGFRA mutations reported in gastrointestinal stromal tumors have been considered to be a driving pathogenetic force.
  • This study showed consistent expression and common mutational activation of PDGFRA in small intestinal inflammatory fibroid polyps as in their gastric counterparts, and these lesions should be considered PDGFRA-driven benign neoplasms.
  • [MeSH-major] Biomarkers, Tumor / genetics. Intestinal Neoplasms / genetics. Intestinal Polyps / genetics. Leiomyoma / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. Female. Gastrointestinal Stromal Tumors / genetics. Humans. Immunohistochemistry. Intestine, Small / pathology. Male. Middle Aged. Mutation. Polymerase Chain Reaction. Young Adult

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  • (PMID = 19448595.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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59. Zhang L, Chen YJ, Shang CZ, Zhong F, Zhang HW, Chen JS: [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Jul;10(4):356-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases].
  • OBJECTIVE: To summarize the pathological classification, clinical symptom and experience in the diagnosis and treatment of primary tumor of small intestine.
  • METHODS: Data of 58 patients with primary tumor of small intestine pathologically confirmed from Oct.
  • RESULTS: Thirteen patient (22.4%) had primary benign tumors of small intestine and 45 patient (77.6%) had primary malignant tumors of small intestine.
  • The major clinical signs of primary tumor of small intestine included hemorrhage(85%), abdomen pain(19%), abdomen mass and intestine obstruction(16%).
  • CONCLUSIONS: Primary tumors of small intestine are difficult to be diagnosed preoperatively.
  • Laparotomy of abdominal cavity is the main choice for those patients with suspicious tumor of small intestine.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 17659462.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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60. Lu CC, Sheu BS, Chen TW, Yang HB, Hung KH, Kao AW, Chuang CH, Wu JJ: Host TNF-alpha-1031 and -863 promoter single nucleotide polymorphisms determine the risk of benign ulceration after H. pylori infection. Am J Gastroenterol; 2005 Jun;100(6):1274-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Host TNF-alpha-1031 and -863 promoter single nucleotide polymorphisms determine the risk of benign ulceration after H. pylori infection.
  • OBJECTIVES: This study tested whether host genotypes of the tumor necrosis factor-alpha (TNF-alpha) promoter single nucleotide polymorphism (SNP) could determine clinical and histological outcomes after Helicobacter pylori infection.
  • For patients with gastric ulcer, the 863CC genotype had a higher rate to have intestinal metaplasia than -863A carrier (p<or=0.005).
  • [MeSH-major] DNA / genetics. Gastric Mucosa / metabolism. Helicobacter Infections / complications. Polymorphism, Single Nucleotide. Promoter Regions, Genetic / genetics. Stomach Ulcer / etiology. Tumor Necrosis Factor-alpha / genetics

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  • (PMID = 15929757.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Tumor Necrosis Factor-alpha; 9007-49-2 / DNA
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61. Nagaraj PB, Ongole R, Bhujanga-Rao BR: Granular cell tumor of the tongue in a 6-year-old girl--a case report. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E162-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the tongue in a 6-year-old girl--a case report.
  • Granular cell tumor is a relatively uncommon benign hamartomatous lesion occurring in almost any part of the body.
  • Granular cell lesions may be found in other diverse sites such as the jaw, skin, gastro intestinal tract and respiratory tract.
  • The tumor generally occurs in middle or older aged adults.
  • As most of the granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • We describe a case of granular cell tumor of the tongue in a 6 year old girl along with a brief review of literature on granular cell tumors.
  • [MeSH-major] Granular Cell Tumor. Tongue Neoplasms

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  • (PMID = 16505796.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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62. Agaimy A, Bihl MP, Tornillo L, Wünsch PH, Hartmann A, Michal M: Calcifying fibrous tumor of the stomach: clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesis. Am J Surg Pathol; 2010 Feb;34(2):271-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calcifying fibrous tumor of the stomach: clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesis.
  • Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor composed of hyalinized fibrous tissue with interspersed bland fibroblastic spindled cells, scattered psammomatous, and/or dystrophic calcifications and variably prominent mononuclear inflammatory infiltrate.
  • To date, 6 gastric and 3 intestinal CFTs have been reported.
  • Mean tumor size was 2.2 cm.
  • Most tumors originated in the gastric body (6/7).
  • One ulcerated tumor caused iron deficiency anemia and ulcer symptoms.
  • Six tumors involved the muscularis propria with variable submucosal and subserosal extension and 1 arose within thickened muscularis mucosae adjacent to a mucosal invagination.
  • In none of the cases were there remnants of burnt-out GIST, inflammatory fibroid polyp, inflammatory myofibroblastic tumor, leiomyoma, schwannoma, or other specific lesion.
  • All tumors were negative for CD117, S100, smooth muscle actin, desmin, ALK1, h-caldesmon, and PDGFRA.
  • All 5 tumors with available tissue for molecular analysis were wild-type for KIT and PDGFRA.
  • [MeSH-major] Calcinosis / pathology. Neoplasms, Fibrous Tissue / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. DNA Mutational Analysis. Female. Humans. Incidental Findings. Male. Middle Aged

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  • (PMID = 20090503.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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63. Otomi Y, Otsuka H, Morita N, Terazawa K, Harada M, Nishitani H: A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor. J Med Invest; 2009 Feb;56(1-2):76-9
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  • [Title] A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor.
  • Other subcutaneous masses considered benign and neurogenic in nature also showed FDG uptake (SUVmax around 3 or less), but the degree of FDG uptake differed considerably from the left femoral mass.
  • Incidentally, PET/CT also showed an asymptomatic large abdominal mass with intense FDG uptake (SUVmax 8.8).
  • The abdominal mass was resected and confirmed as gastrointestinal stromal tumor (GIST) of the small intestine.
  • Three months later, the left femoral mass was operated on and pathologically diagnosed as a malignant peripheral nerve sheath tumor (MPNST).
  • We present a rare case of a patient with vRd with a MPNST of the left femur and coincidental GIST of the small intestine.
  • [MeSH-major] Bone Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Intestinal Neoplasms / complications. Nerve Sheath Neoplasms / complications. Osteitis Fibrosa Cystica / complications
  • [MeSH-minor] Femur / radiography. Femur / radionuclide imaging. Fluorodeoxyglucose F18. Humans. Intestine, Small / radiography. Intestine, Small / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19262018.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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64. Jang JY, Park YC, Song YS, Lee SE, Hwang DW, Lim CS, Lee HE, Kim WH, Kim SW: Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas. J Hepatobiliary Pancreat Surg; 2009;16(5):668-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas.
  • PURPOSE: The purpose of this study was to document the biological changes during the progression of intraductal papillary mucinous neoplasm of the pancreas (IPMN) and to identify biological markers capable of differentiating benign and malignant IPMN.
  • The paraffin-embedded tumors from 27 with benign IPMNs and from 14 with IPMCs were subjected to immunohistochemical staining and DNA extraction.
  • RESULTS: K-ras mutations at codon 12 and 13 were detected in 13 of 37 (38.2%) of the IPMNs: in 5 of 24 (20.8%) of benign IPMNs, and in 8 of 13 (61.5%) of malignant IPMNs (p = 0.028).
  • S100A4 was expressed in 2 (7.4%) of 27 benign IPMNs, and 6 (42.9%) of 14 malignant IPMNs (p = 0.007).
  • MUC2 was expressed in 2 (7.4%) benign IPMNs, and in 9 (64.3%) malignant IPMNs (p < 0.001).
  • CONCLUSION: K-ras mutation and the expression of S100A4 and MUC2 (especially in intestinal subtype) were found to be related to malignancy in IPMN, and may be useful for the diagnosis and for assessing the biological behavior of IPMN.
  • [MeSH-major] Biomarkers, Tumor / genetics. Carcinoma, Pancreatic Ductal / genetics. Mucin-2 / genetics. Pancreatic Neoplasms / genetics. S100 Proteins / metabolism
  • [MeSH-minor] Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Genes, ras. Humans. Immunohistochemistry. Male. Middle Aged. Mutation. Neoplasm Staging. Polymerase Chain Reaction. Probability. Prognosis. Retrospective Studies. Statistics, Nonparametric. Survival Rate

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  • (PMID = 19412570.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-2; 0 / S100 Proteins
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65. Lizarbe MO, Olascoaga JH, García ER, Castiella TM, Sagaseta de Ilúrdoz Uranga María M, Garicano JM: [Paediatric myofibroblastic tumours. A presentation of three cases]. An Pediatr (Barc); 2009 Oct;71(4):331-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Tumor miofibroblástico en la edad pediátrica. A propósito de 3 casos.
  • This a rare benign disease, that can develop into malignant forms.
  • The symptoms that indicated the location of the tumour were, haematemesis in the first case, and respiratory disease in the third.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Intestinal Diseases / diagnosis. Lung Diseases / diagnosis. Stomach Diseases / diagnosis

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  • [CommentIn] An Pediatr (Barc). 2010 Oct;73(4):221-2 [20705527.001]
  • (PMID = 19647502.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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66. Fingleton B, Powell WC, Crawford HC, Couchman JR, Matrisian LM: A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. Hybridoma (Larchmt); 2007 Feb;26(1):22-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunostaining of MMP-7 in normal tissues or benign tumors of intestinal, breast, and prostatic origin indicates that this protein is normally localized luminally in glandular epithelium.
  • The localization pattern would suggest that in normal or early stage tumors, MMP-7 is most likely not directly involved in extracellular matrix degradation.
  • In contrast, advanced colon tumors show MMP-7 in invading cells at the advancing edge of the tumor.

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  • (PMID = 17316082.001).
  • [ISSN] 1554-0014
  • [Journal-full-title] Hybridoma (2005)
  • [ISO-abbreviation] Hybridoma (Larchmt)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA60867; United States / NCI NIH HHS / CA / R01 CA84360; United States / NIAMS NIH HHS / AR / AR36457; United States / NCI NIH HHS / CA / R01 CA084360; United States / NIAMS NIH HHS / AR / P30 AR48311; United States / NIAMS NIH HHS / AR / P30 AR048311; United States / NCI NIH HHS / CA / R01 CA100126; United States / NCI NIH HHS / CA / R01 CA060867
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Enzyme Precursors; EC 3.4.24.23 / Matrix Metalloproteinase 7
  • [Other-IDs] NLM/ NIHMS403810; NLM/ PMC3838102
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67. Skrzypczak M, Goryca K, Rubel T, Paziewska A, Mikula M, Jarosz D, Pachlewski J, Oledzki J, Ostrowski J: Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One; 2010;5(10)
SciCrunch. ArrayExpress: Data: Microarray .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability.
  • Based on a consensus of the results obtained by two normalization algorithms, and two probe set sorting criteria, we identified 14 and 17 KEGG signaling and metabolic pathways that are significantly altered between normal and tumor samples and between benign and malignant tumors, respectively.
  • [MeSH-major] Adenocarcinoma / metabolism. Colonic Neoplasms / metabolism. Oligonucleotide Array Sequence Analysis. Oncogenes. Signal Transduction
  • [MeSH-minor] Algorithms. Humans. Intestinal Mucosa / metabolism. Reproducibility of Results

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  • [ErratumIn] PLoS One. 2010;5(12) doi: 10.1371/annotation/8c585739-a354-4fc9-a7d0-d5ae26fa06ca. Ostrowsk, Jerzy [corrected to Ostrowski, Jerzy]
  • (PMID = 20957034.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2948500
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68. Cervantes-Solís C, Jiménez-González A, Zamora-Nava LE, Torre-Delgadillo A: [Thickening of the colon and terminal ileum documented with computer tomography and its correlation with colonoscopic findings at a third-level hospital]. Rev Gastroenterol Mex; 2010;75(2):158-64
MedlinePlus Health Information. consumer health - CT Scans.

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  • Various radiographic patterns of intestinal thickening suggestive of benign disease have been described, but they cannot completely rule out malignancy.
  • The most common colonoscopic finding was colorectal tumor probably malignant in 7 (29.2%) patients, but adenocarcinoma was reported in 8 (33.3%) patients.
  • [MeSH-major] Colon / pathology. Colon / radiography. Colonic Neoplasms / diagnosis. Colonoscopy. Ileum / pathology. Ileum / radiography. Tomography, X-Ray Computed

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  • (PMID = 20615783.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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69. Tanigawa N, Nomura E, Lee SW, Kaminishi M, Sugiyama M, Aikou T, Kitajima M, Society for the Study of Postoperative Morbidity after Gastrectomy: Current state of gastric stump carcinoma in Japan: based on the results of a nationwide survey. World J Surg; 2010 Jul;34(7):1540-7
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Carcinoma of the gastric remnant after partial gastrectomy for benign disease or cancer is unusual but an important cancer model.
  • METHODS: In the questionnaire survey of November 2008, gastric stump carcinoma was defined as an adenocarcinoma of the stomach occurring 10 years or more after Billroth I or Billroth II gastrectomy for benign condition or cancer disease.
  • Items for the survey included gender, age, methods of reconstruction in an original gastrectomy, original diseases, time interval between original gastrectomy and first detection of stump carcinomas, locations of stump carcinomas, tumor histology, tumor depth, and extent of lymph node metastasis.
  • The Billroth II group has a significantly higher number of original benign lesions than the Billroth I group (P < 0.001).
  • (3) Tumor histology of 72.4% of 304 stump carcinomas at an early stage was intestinal type adenocarcinoma, i.e., well or moderately differentiated adenocarcinoma, whereas it decreased to 42.2% at the locally advanced stage of 521 stump carcinomas (P = 0.0015), suggesting that stump carcinoma mostly may develop from intestinal type and change to diffuse type during the evolution to advanced stage cancers.
  • CONCLUSIONS: This large series of surveys suggest that there are two distinct biological plausibilities in the development of gastric stump carcinoma:.
  • (1) it develops in a shorter time interval of 10 years or less since the original gastrectomy, may come from a higher risk of gastric mucosa after gastrectomy for cancer diseases that highly predisposes to cancer, and (2) it develops during a longer time interval of 20 years or more, may come from gastrectomy-relating mechanisms after gastrectomy for original benign diseases.
  • [MeSH-major] Adenocarcinoma / epidemiology. Gastric Stump. Stomach Neoplasms / epidemiology

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  • (PMID = 20182716.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2895900
  • [Investigator] Katai H; Takashima S; Kinoshita T; Yamamura Y; Kunisaki T; Tajiri T; Takenaka A; Otsuji E; Fuji Y; Tsurumaru M; Ogawa K; Saito H; Ota T; Nagai H; Yamazaki Y; Kaminishi M; Takiyama W; Sakuramoto S; Sasaki M; Tanigawa N; Hirakawa K; Fujiya T; Fujii H; Iwasaka N; Ooi E; Matsubara Y; Matsushita T; Tatsumi M; Yamamoto Y; Arita T; Wakabayashi G; Takiguchi N; Kitamura M; Nagata N; Watanabe S; Kimura W; Bandai Y; Kasai S; Hishiyama T; Yamada T; Kitano S; Monden M; Takabatake T; Yoshikawa T; Maehara Y; Oshita H; Nashimoto A; Ishida H; Sasaki I; Ishikawa H; Tani T; Kurita H; Kumagai K; Kusano M; Furukawa H; Konishi F; Kondo Y; Nakada K; Yamamoto M; Iwasaki Y; Inada T; Arai K; Sunagawa M; Shimizu T; Tamiya Y; Tokunaga A; Takayama T; Ishida Y; Ninomiya M; Goto M; Uyama I; Naito H; Mochizuki H; Miyata N; Naito H; Oka M; Tsuji T; Miyashiro I; Aoki T; Kanematsu T; Morita T; Tanaka K; Monden T; Yamasaki Y; Takahashi M; Fujii Y; Shiozaki H; Sugiyama Y
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70. Balci S, Saglam A, Usubutun A: Primary signet-ring cell carcinoma of the cervix: case report and review of the literature. Int J Gynecol Pathol; 2010 Mar;29(2):181-4
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mucinous adenocarcinoma of the cervix has 5 subtypes: endocervical, intestinal, signet-ring cell, minimal deviation, and villoglandular.
  • DNA extraction from paraffin-embedded tissue revealed the presence of human papilloma virus (HPV) type 18, which supports the cervical origin of the tumor.
  • Signet-ring cell morphology can be observed in both benign and malignant lesions of the uterine cervix.
  • [MeSH-major] Carcinoma, Signet Ring Cell / pathology. Papillomaviridae / genetics. Papillomavirus Infections / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 20173504.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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71. Tamura H, Ohtsuka M, Washiro M, Kimura F, Shimizu H, Yoshidome H, Kato A, Seki N, Miyazaki M: Reg IV expression and clinicopathologic features of gallbladder carcinoma. Hum Pathol; 2009 Dec;40(12):1686-92
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Regenerating islet-derived family, member 4 (Reg IV) has been shown to be associated with colorectal carcinogenesis and gastric carcinogenesis through intestinal metaplasia.
  • Immunohistochemically, although only a small part of the epithelium with intestinal metaplasia in 2 of 4 cases with adenomyomatosis showed Reg IV expression, Reg IV was negative in all cases with normal gallbladder (n = 15) and cholelithiasis (n = 13).
  • Expression was more frequently observed in well to moderately differentiated than in poorly differentiated adenocarcinomas and significantly correlated with expression of caudal-related homeobox transcription factor (a candidate for involvement in the induction of intestinal metaplasia).
  • Before surgical resection, 4 (33%) of 12 patients with gallbladder carcinoma had high serum Reg IV levels, whereas Reg IV was never elevated in 12 patients with benign diseases.
  • The serum levels of Reg IV decreased after surgical resection of the tumors.
  • These results suggest that Reg IV is involved in gallbladder carcinoma carcinogenesis through intestinal metaplasia and is associated with relatively favorable prognosis in patients after surgery.
  • The serum level of Reg IV may be of use or indicative of neoplasia.
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Lectins, C-Type / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Enzyme-Linked Immunosorbent Assay. Gene Expression. Homeodomain Proteins / biosynthesis. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Metaplasia / genetics. Metaplasia / metabolism. Metaplasia / pathology. Neoplasm Staging. Prognosis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19716164.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Lectins, C-Type; 0 / REG4 protein, human
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72. Chung WC, Kim HK, Yoo JY, Lee JR, Lee KM, Paik CN, Jang UI, Yang JM: Colonic lymphangiomatosis associated with anemia. World J Gastroenterol; 2008 Oct 7;14(37):5760-2
MedlinePlus Health Information. consumer health - Anemia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment, resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain, bleeding, intussusceptions.
  • [MeSH-major] Anemia / etiology. Colonic Neoplasms / complications. Lymphangioma / complications
  • [MeSH-minor] Abdominal Pain / etiology. Colonoscopy. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18837097.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
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73. Shelekhova KV, Hejda V, Kazakov DV, Michal M: Mature cystic teratoma of the ovary with male accessory sexual glands including seminal vesicles, prostatic tissue, and bulbo-urethral glands: a case report. Virchows Arch; 2008 Jan;452(1):109-11
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present an extremely rare case of a benign cystic ovarian teratoma with structures of male accessory sexual glands.
  • A unilocular cystic tumor, measuring 5 cm in the largest diameter, was found in her right ovary and was removed.
  • The teratoma contained epidermis, skin appendages, respiratory and intestinal epithelia, cartilage, muscle, and nervous and connective tissue.
  • [MeSH-major] Bulbourethral Glands / pathology. Ovarian Neoplasms / pathology. Prostate / pathology. Seminal Vesicles / pathology. Teratoma / pathology

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  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
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74. Lasota J, vel Dobosz AJ, Wasag B, Wozniak A, Kraszewska E, Michej W, Ptaszynski K, Rutkowski P, Sarlomo-Rikala M, Steigen SE, Schneider-Stock R, Stachura J, Chosia M, Ogun G, Ruka W, Siedlecki JA, Miettinen M: Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors. Lab Invest; 2007 Oct;87(10):1029-41
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  • [Title] Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors.
  • Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of gastrointestinal tract.
  • GISTs range from benign indolent neoplasms to highly malignant sarcomas.
  • In this study, we report 36 GIST patients whose tumors had homozygous KIT exon 11 mutations detected by direct sequencing of PCR products.
  • Loss of heterozygosity in KIT locus and other chromosome 4 loci were documented in majority of these tumors.
  • Homozygous KIT exon 11 mutations were found in 33 primary tumors and 7 metastatic lesions.
  • In two cases, shift from heterozygosity to homozygosity was documented during tumor progression being present in metastases, but not in primary tumors.
  • Among primary GISTs, there were 16 gastric, 18 intestinal and 2 from unknown locations.
  • An average primary tumor size was 12 cm and average mitotic activity 32/50 HPFs.
  • Out of 32 tumors 29 (90.6%) with complete clinicopathologic data were diagnosed as sarcomas with more than 50% risk of metastatic disease, and 26 of 29 patients with follow-up had metastases or died of disease.
  • [MeSH-major] Gastrointestinal Stromal Tumors / genetics. Loss of Heterozygosity. Neoplasm Metastasis / genetics. Proto-Oncogene Proteins c-kit / genetics

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  • [CommentIn] Lab Invest. 2008 May;88(5):456-7 [18432212.001]
  • (PMID = 17632543.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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75. Lafontaine PO, Arnal M, Buron N, Solary E, Bron AM, Westley BR, May FE, Bara J, Gespach C, Creuzot-Garcher C: Trefoil factor family mRNA and protein expression in pterygium. Int J Oncol; 2005 Oct;27(4):997-1003
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  • The cellular expression of TFF1 (pS2), TFF3 (intestinal trefoil factor) and M1/MUC5AC mucin in ten pterygia and ten normal human conjunctiva specimens was analyzed by immunohistochemistry using specific monoclonal antibodies.
  • Increased expression of TFF1 mRNA and protein is observed in pterygium GC, suggesting that this trefoil protein might exert protective and beneficial roles during the pathogenesis of this benign and inflammatory conjunctival tumor.
  • [MeSH-major] Conjunctiva / metabolism. Gene Expression Regulation. Peptides / metabolism. Pterygium / metabolism. RNA, Messenger / metabolism. Tumor Suppressor Proteins / biosynthesis

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  • (PMID = 16142316.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins; 0 / Peptides; 0 / RNA, Messenger; 0 / TFF1 protein, human; 0 / TFF3 protein, human; 0 / Tumor Suppressor Proteins; 146046-78-8 / trefoil factor
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76. Serra S, Asa SL, Bamberger AM, Wagener C, Chetty R: CEACAM1 expression in pancreatic endocrine tumors. Appl Immunohistochem Mol Morphol; 2009 Jul;17(4):286-93
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  • [Title] CEACAM1 expression in pancreatic endocrine tumors.
  • The aim of this study was to examine the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in pancreatic endocrine tumors (PETs) and to correlate it with clinicopathologic parameters.
  • Sixty-nine PETs were examined for tumor size, necrosis, local peripancreatic invasion and lymphovascular invasion, lymph node, and liver metastasis.
  • The mitotic count, expressed per 10 high-power fields (HPF) and MIB1 index were assessed and tumors were classified according to the World Health Organization classification.
  • Twenty-nine tumors were from males and 40 from females, age range: 23 to 80 years (mean 52.4 y), tumor size ranged from 0.8 to 11 cm (mean 3.5 cm), 8 patients had multiple endocrine neoplasia 1 syndrome, and 1 had von Hippel-Lindau disease.
  • Twenty tumors demonstrated local invasion, 32 had lymphovascular invasion, 16 had lymph node metastasis, and 10 had liver metastasis.
  • In addition, 80% of tumors >or=2 cm in diameter were CEACAM positive (P<0.05).
  • CEACAM1-positive tumors were more frequently insulin negative (9 of 10 cases) (P=0.005) and vasoactive intestinal peptide-positive PETs were all CEACAM1 immunopositive (7 of 7 cases) (P=0.005).
  • Benign tumors and PETs of uncertain malignant behavior were more frequently CEACAM1-negative and low-grade malignant cases were CEACAM1 positive (27 of 29 cases) (P=0.001).
  • In addition, CEACAM1-positive tumors were statistically correlated with cytokeratin 19-positive tumors (P<0.05).

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  • (PMID = 19349857.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD66 antigens; 0 / Cell Adhesion Molecules; 0 / Neoplasm Proteins
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77. Ferreira CR, Carvalho JP, Soares FA, Siqueira SA, Carvalho FM: Mucinous ovarian tumors associated with pseudomyxoma peritonei of adenomucinosis type: immunohistochemical evidence that they are secondary tumors. Int J Gynecol Cancer; 2008 Jan-Feb;18(1):59-65
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  • [Title] Mucinous ovarian tumors associated with pseudomyxoma peritonei of adenomucinosis type: immunohistochemical evidence that they are secondary tumors.
  • Pseudomyxoma peritonei (PMP) is a clinical condition initially thought to be related to ovarian mucinous tumors; however, immunohistochemistry and molecular biology techniques have convincingly made the link to appendiceal mucinous neoplasms, resulting in changes in histologic and clinical approaches.
  • The objective of this study was to compare the immunohistochemical profile of ovarian tumors associated with PMP and intestinal mucinous ovarian neoplasms without PMP.
  • The study was retrospective and included 28 intestinal ovarian mucinous tumors selected from the files of the Division of Surgical Pathology of the University of Sao Paulo Medical School, from 1996 to 2005.
  • Comparisons of borderline histology with that of benign/malignant tumors also revealed differences in MUC2 and CK20.
  • Our results confirm that there is a distinct profile of intestinal ovarian tumors associated with pseudomyxoma, particularly with respect to the expression of the gel-forming mucin MUC2.
  • The profile of borderline tumors, even in cases without PMP, was distinct from that of other primary mucinous tumors of the intestinal type, suggesting that borderline histology may represent a secondary tumor or a less aggressive variant of PMP.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Biomarkers, Tumor / metabolism. Intestinal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology. Pseudomyxoma Peritonei / pathology

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  • (PMID = 17511804.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Mucins
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78. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • [Title] A shift in the diagnostics of the small intestine tumors.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • METHODOLOGY: A retrospective study comprising 96 patients having undergone surgery for a small intestine tumor in our hospital from 1996 to 2005 is presented.
  • In the year 1998 we changed our philosophy in trying to directly detect the small intestine pathology and not making the diagnosis by the exclusion only.
  • Intestinal ultrasound was performed on the Ultramark 3000 HDI device with autofocussable convex 5 MHz and linear 7.5 MHz probes or nowadays ATL 5000 HDI, 7-12 MHz linear probe.
  • RESULTS: We treated surgically 96 patients with the small intestine tumor.
  • CONCLUSION: The small bowel ultrasound can be recommended as the first choice method.
  • All patients with even very moderate abdominal symptoms ought to be examined for the small intestine pathology.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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79. Gao Y, Zhang B: [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality]. Ai Zheng; 2009 Dec;28(12):1277-82
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  • [Title] [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality].
  • BACKGROUND AND OBJECTIVE: Telomerase transcriptional elements-interacting factor (TEIF) gene found recently by our research group is a transcription factor of a kind of human telomerase reverse transcriptase (hTERT) gene, and expresses in many kinds of tumor tissues.
  • This study was to evaluate the expression of TEIF protein in human colorectal tumors and to explore its correlation with centrosome abnormality.
  • METHODS: The expression of TEIF in 10 specimens of normal intestinal mucosa tissue, 30 specimens of colorectal cancer, and 54 specimens of colorectal adenoma was detected by immunohistochemistry.
  • RESULTS: Immunohistochemistry results showed that the differences of TEIF protein expression between the normal group and each tumor groups were statistically significant (P<0.01), and the difference of TEIF protein expression between the malignant tumor group and the benign group was not significant (P>0.05).
  • CONCLUSIONS: TEIF protein and centrosome amplification is commonly found in colorectal tumors.
  • The expression level of TEIF is related to tumor histological grade and malignant degree.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Centrosome / pathology. Colorectal Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Male. Middle Aged. Tubulin / metabolism

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  • (PMID = 19958622.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Transcription Factors; 0 / Tubulin; EC 2.7.1.- / SCYL1 protein, human
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80. Lisovsky M, Dresser K, Baker S, Fisher A, Woda B, Banner B, Lauwers GY: Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol; 2009 Jul;22(7):977-84
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  • The Lethal giant larvae (lgl) gene controls apical-basal polarity of epithelial cells in Drosophila, and has properties of a tumor-suppressor gene.
  • Routinely processed pathology specimens including 94 benign mucosae of digestive organs, in addition to 36 reactive gastropathy, 57 gastric epithelial dysplasia, and 77 gastric adenocarcinomas, were immunostained for Lgl2 protein.
  • Normal esophageal, duodenal, colonic, biliary, and pancreatic duct mucosae, as well as gastric intestinal metaplasia, did not express Lgl2.
  • Complete loss of immunoreactivity was significantly more often observed in diffuse-type than in intestinal-type adenocarcinomas (79 vs 48%, respectively).
  • However, the consistently negative anti-Lgl2 immunoreactivity seen in intestinal metaplasia does not allow differentiation of dysplasia from intestinal metaplasia with reactive change.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cytoskeletal Proteins / metabolism. Gastric Mucosa / metabolism. Precancerous Conditions / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 19407852.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Hugl-2 protein, human
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81. Daum O, Hatlova J, Mandys V, Grossmann P, Mukensnabl P, Benes Z, Michal M: Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). Virchows Arch; 2010 May;456(5):491-7
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  • [Title] Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors).
  • Vanek's tumor (inflammatory fibroid polyp) is a rare benign lesion occurring throughout the digestive tract.
  • Classical Vanek's tumor contains concentric formations of proliferating spindle cells which are CD34 positive.
  • Atypical, inflammatory pseudotumor-like Vanek's tumor lacks concentric formations and is CD34 negative.
  • Recently, mutations in platelet-derived growth factor receptor alpha (PDGFRA) were reported in gastric and small intestinal Vanek's tumors.
  • In this study, KIT exons 9, 11, 13, and 17, PDGFRA exons 12, 14, and 18, and a part of exon 15 BRAF for point mutation V600E were screened in 23 cases of Vanek's tumor, both classical (n = 16) and inflammatory pseudotumor-like (n = 7).
  • Six Vanek's tumors harbored activating mutations in PDGFRA exons 12 (n = 5) and 18 (n = 1) respectively: S566_E571delinsK (n = 1), S566_E571delinsR (n = 4), and D842 del (n = 1).
  • The mutations were detected in the classical (n = 5), as well as inflammatory pseudotumor-like (n = 1) Vanek's tumors.
  • The results of this study suggest that the two morphological patterns of Vanek's tumor more probably represent only variants of one type of tumor than two different lesions.
  • Furthermore, BRAF mutations were not shown to drive growth of PDGFRA wild-type Vanek's tumors.
  • [MeSH-major] Intestinal Diseases / pathology. Leiomyoma / genetics. Leiomyoma / pathology. Polyps / genetics. Polyps / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics. Stomach Diseases / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Exons. Female. Gastrointestinal Tract / pathology. Humans. Male. Middle Aged. Mutation. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 20393746.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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82. Wani I: Mesenteric lymphangioma in adult: a case series with a review of the literature. Dig Dis Sci; 2009 Dec;54(12):2758-62
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  • Mesenteric lymphangioma is a rare benign tumor with nonspecific clinical features.
  • Two patients presented with painless abdominal swelling who were being managed as a case of abdominal tuberculosis and a third one had features of intestinal obstruction.
  • [MeSH-major] Lymphangioma / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Antitubercular Agents / therapeutic use. Diagnostic Errors. Humans. Intestinal Obstruction / etiology. Male. Mesentery. Middle Aged. Tuberculosis, Gastrointestinal / diagnosis. Tuberculosis, Gastrointestinal / drug therapy. Tuberculosis, Lymph Node / diagnosis. Tuberculosis, Lymph Node / drug therapy. Unnecessary Procedures. Young Adult

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  • [Copyright] © Springer Science+Business Media, LLC 2009
  • (PMID = 19142726.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents
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83. Park SB, Ha HK, Kim AY, Lee SS, Kim HJ, Park BJ, Jin YH, Park SH, Kim KW: The diagnostic role of abdominal CT imaging findings in adults intussusception: focused on the vascular compromise. Eur J Radiol; 2007 Jun;62(3):406-15
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  • Intussusception is defined as telescoping of one segment of the gastrointestinal tract into an adjacent one.
  • More than 90% of patients with adult intussusception have been reported to have an organic cause, with benign or malignant tumors for accounting for approximately 65% of the cases.
  • Therefore, determination of the presence or absence of intestinal necrosis in intussusception is important in patient management.
  • On CT, the presence of well-known diagnostic CT criteria for strangulated obstruction (especially severe engorgement or twisting of the mesenteric vessels) as well as evidence of loss of the layered pattern, accumulation of extraluminal fluid collection, and bowel perforation, may suggest the diagnosis of intestinal necrosis.
  • However, CT and MR provide excellent pre-operative evaluation, including the possible extension and/or dissemination of a malignant tumor.
  • [MeSH-major] Intestinal Neoplasms / complications. Intestines / blood supply. Intestines / radiography. Intussusception / diagnosis. Radiography, Abdominal / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 17412545.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide; JR13W81H44 / Iopamidol
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84. Schildhaus HU, Merkelbach-Bruse S, Binot E, Büttner R, Wardelmann E: [Inflammatory fibroid polyp: from Vanek's "submucosal granuloma" to the concept of submucosal mesenchymal neoplasia]. Pathologe; 2010 Mar;31(2):109-14
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  • [Title] [Inflammatory fibroid polyp: from Vanek's "submucosal granuloma" to the concept of submucosal mesenchymal neoplasia].
  • IFP represent polypous proliferations of spindle cells in the submucosa and mucosa of the stomach, small bowel and colon with inflammatory infiltration.
  • Therefore, IFP represent true benign mesenchymal tumors of the gastrointestinal tract.
  • [MeSH-major] Eosinophilic Granuloma / pathology. Gastrointestinal Neoplasms / pathology. Leiomyoma / pathology. Polyps / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. DNA Mutational Analysis. Diagnosis, Differential. Gastric Mucosa / pathology. Gastritis / pathology. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology. Helicobacter Infections / genetics. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Intestinal Mucosa / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics. Sequence Analysis, DNA. Sequence Analysis, Protein

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  • [Cites] Appl Immunohistochem Mol Morphol. 2004 Mar;12(1):59-66 [15163021.001]
  • (PMID = 20107807.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 23
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85. Shiroshita H, Komori Y, Tajima M, Bandoh T, Arita T, Shiraishi N, Kitano S: Laparoscopic examination and resection for giant lipoma of the omentum: a case report and review of related literature. Surg Laparosc Endosc Percutan Tech; 2009 Oct;19(5):e217-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Laparoscopic examination revealed a smooth-surfaced, giant yellow tumor at the lower border of the greater omentum that was unattached to the surrounding organs.
  • After laparoscopic resection of the tumor and cholecystectomy, a 10-cm midline incision was made in the lower abdomen to remove the tumor and the gallbladder.
  • The resected tumor measured 29 x 19 x 3 cm and weighed 1250 g, and a histopathologic examination revealed a benign lipoma.
  • [MeSH-major] Cholecystectomy, Laparoscopic. Lipoma / surgery. Omentum / surgery. Peritoneal Neoplasms / surgery. Sigmoid Neoplasms / surgery

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  • (PMID = 19851258.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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86. Cha JM, Lee JI, Joo KR, Choe JW, Jung SW, Shin HP, Kim HC, Lee SH, Lim SJ: Giant mesenteric lipoma as an unusual cause of abdominal pain: a case report and a review of the literature. J Korean Med Sci; 2009 Apr;24(2):333-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Despite the benign nature of this tumor, total excision with or without the affected intestinal loop should be considered if intestinal symptoms such as abdominal pain are present.
  • [MeSH-major] Abdominal Pain / etiology. Lipoma / diagnosis. Mesentery. Peritoneal Neoplasms / diagnosis

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  • [Cites] Surg Today. 2003;33(8):617-9 [12884101.001]
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  • (PMID = 19399281.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 23
  • [Other-IDs] NLM/ PMC2672139
  • [Keywords] NOTNLM ; Abdominal Pain / Computed Tomography / Laparoscopy / Lipoma / Mesentery
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87. Yu DC, Javid PJ, Chikwava KR, Kozakewich HP, Debiec-Rychter M, Lillehei CW, Weldon CB: Mesenteric lipoblastoma presenting as a segmental volvulus. J Pediatr Surg; 2009 Feb;44(2):e25-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mesenteric lipoblastoma is a rare tumor and, its presentation as a bowel obstruction with possible midgut volvulus has only been reported once before.
  • A 7-year-old girl presented with nausea and vomiting but a benign abdominal examination.
  • During emergency laparotomy, segmental small bowel volvulus secondary to a large mesenteric lipoblastoma was found.
  • The lipoblastoma was resected with a segment of small bowel.
  • Resection margins were negative for tumor, and the patient is doing well with no evidence of recurrence.
  • [MeSH-major] Intestinal Obstruction / etiology. Intestinal Volvulus / etiology. Intestine, Small. Mesentery. Peritoneal Neoplasms / complications

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  • (PMID = 19231517.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Kapran Y, Bauersfeld J, Anlauf M, Sipos B, Klöppel G: Multihormonality and entrapment of islets in pancreatic endocrine tumors. Virchows Arch; 2006 Apr;448(4):394-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multihormonality and entrapment of islets in pancreatic endocrine tumors.
  • We analyzed pancreatic endocrine tumors (PETs) from 200 patients for the incidence of multihormonality and entrapped islets and correlated the results with clinicopathological features.
  • Classified according to the WHO classification, there were 32 well-differentiated benign PETs, 85 well-differentiated PETs with uncertain behavior, and 83 well-differentiated malignant PETs.
  • All tumors were immunostained for pancreatic hormones (insulin, glucagon, somatostatin, and pancreatic polypeptide) and for additional hormones such as gastrin, vasoactive intestinal polypeptide, calcitonin, seratonin, and adrenocorticotropic hormone.
  • Multihormonality was found in 34% of all PETs and it was a frequent finding in the tumors of the uncertain behavior (38.8%) group.
  • Islet entrapment was found in 57 tumors (28.5%) and was significantly more frequent in PETs with uncertain and malignant behavior than benign ones (p=0.01).
  • Of these 57 tumors, 45 (79%) tumors had accompanying ductule entrapment.
  • Ductule entrapment did not show significant correlation with malignancy and was a more frequent finding in nonfunctioning tumors.
  • We conclude that the incidence of multihormonality in PETs is not as high as suggested previously and islet entrapping may reflect aggressive tumor growth and may be a complementary criterion for predicting the biological behavior of PETs.
  • [MeSH-major] Adenoma, Islet Cell / pathology. Carcinoma, Islet Cell / pathology. Islets of Langerhans / pathology. Pancreatic Hormones / metabolism. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Count. Child. Child, Preschool. Female. Humans. Male. Middle Aged

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  • (PMID = 16418841.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Pancreatic Hormones
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89. Kala Z, Kysela P, Meluzinova H: Small-bowel tumors in the elderly 65+ years: 10 years of experience. Z Gerontol Geriatr; 2008 Oct;41(5):403-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small-bowel tumors in the elderly 65+ years: 10 years of experience.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work represents a prospective evaluation of a diagnostic and therapeutic algorithm in the management of the small-intestine tumor below the ligamentum Treitzi in patients over 65 years of age.
  • RESULTS: A population of 96 patients who underwent surgery for a small-intestinal tumor in our hospital from 1996 to 2006 is presented.
  • Ultrasound of the small intestine was sufficient to make the diagnosis in 21 of them.
  • CONCLUSION: The small-bowel ultrasound can be recommended as the first choice method.
  • All complaints regarding the gastrointestinal tract should be verified.
  • [MeSH-major] Intestinal Neoplasms / surgery. Intestinal Neoplasms / ultrasonography. Intestine, Small / surgery. Intestine, Small / ultrasonography. Ultrasonography / methods

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  • (PMID = 18327695.001).
  • [ISSN] 0948-6704
  • [Journal-full-title] Zeitschrift für Gerontologie und Geriatrie
  • [ISO-abbreviation] Z Gerontol Geriatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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90. Nguyen VX, Nguyen CC, Li B, Das A: Digital image analysis is a useful adjunct to endoscopic ultrasonographic diagnosis of subepithelial lesions of the gastrointestinal tract. J Ultrasound Med; 2010 Sep;29(9):1345-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Digital image analysis is a useful adjunct to endoscopic ultrasonographic diagnosis of subepithelial lesions of the gastrointestinal tract.
  • OBJECTIVE: The purpose of this study was to explore the role of digital image analysis in differentiating endoscopic ultrasonographic (EUS) features of potentially malignant gastrointestinal subepithelial lesions (SELs) from those of benign lesions.
  • METHODS: Forty-six patients with histopathologically confirmed gastrointestinal stromal tumors (GISTs), carcinoids, and lipomas who had undergone EUS evaluation were identified from our database.
  • [MeSH-major] Endosonography. Gastrointestinal Neoplasms / ultrasonography. Image Interpretation, Computer-Assisted / methods
  • [MeSH-minor] Area Under Curve. Carcinoid Tumor / pathology. Carcinoid Tumor / ultrasonography. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / ultrasonography. Humans. Intestinal Mucosa / pathology. Lipoma / pathology. Lipoma / ultrasonography. Neural Networks (Computer). Principal Component Analysis

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  • (PMID = 20733191.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Bonin EA, Baron TH: Update on the indications and use of colonic stents. Curr Gastroenterol Rep; 2010 Oct;12(5):374-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Despite concerns of tumor seeding following endoscopic colorectal stent placement, no difference exists in oncologic long-term survival between patients who undergo stent placement followed by elective resection and those undergoing emergency bowel resection.
  • Colorectal stents have also been used in selected patients with benign colonic strictures.
  • Patients with benign colonic stricture with acute colonic obstruction who are at high risk for emergency surgery can gain temporary relief of obstruction after SEMS placement; the stent can be removed en bloc with the colon specimen at surgery.
  • This article reviews the techniques and indications of SEMS placement for benign and malignant colorectal obstructions.
  • [MeSH-major] Colonoscopy / methods. Colorectal Neoplasms / surgery. Intestinal Obstruction / surgery. Stents / adverse effects
  • [MeSH-minor] Acute Disease. Colon / pathology. Colon / surgery. Colonic Diseases / etiology. Colonic Diseases / surgery. Constriction, Pathologic / surgery. Humans. Palliative Care. Pelvic Neoplasms / complications. Pelvic Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20703837.001).
  • [ISSN] 1534-312X
  • [Journal-full-title] Current gastroenterology reports
  • [ISO-abbreviation] Curr Gastroenterol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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92. Xia SY, Li R, Song SB, Liang FQ: [Diagnosis and surgical therapy of primary retroperitoneal neurogenic tumors]. Zhonghua Yi Xue Za Zhi; 2009 Jun 9;89(22):1567-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and surgical therapy of primary retroperitoneal neurogenic tumors].
  • OBJECTIVE: To explore the diagnosis and surgical therapy for retroperitoneal neurogenic tumors (PRNTs).
  • METHODS: The clinical records of 79 surgically treated patients with retroperitoneal neurogenic tumor were retrospectively analyzed.
  • Pathological analysis identified 19 patients with neurofibroma, 8 with neurilemmoma, 4 with paraganglioma, 21 with neurofibrosarcoma, 14 with malignant neurilemmoma, 6 with malignant paraganglioma, 5 with neuroectodermal tumor and 2 with neuroblastoma.
  • The mortality rate of PRNT operation is was 1.3%, 3-year recurrence rate of benign tumor 0%, 5-year recurrence rate of benign tumor 12.9%, reoperation rate 100%, 5-year survival rate 100%.
  • 3 years recurrence rate of malignancy tumor 41.6%, reoperation rate 90%, 5 years recurrence rate of malignancy tumor 79.1% and 5 years survival rate is 62.5%.
  • Pre-operative preparation of intestinal tract and blood, maintaining the intactness of involved nerve are important for tumor resection.
  • To prevent tumor recurrence, the key surgical techniques are to minimize tumor residues and .
  • [MeSH-major] Neuroectodermal Tumors / diagnosis. Neuroectodermal Tumors / surgery. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / surgery

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  • (PMID = 19953887.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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93. Cesca E, Midrio P, Tregnaghi A, Alaggio R, Bitetti S, Gamba P: Meconium periorchitis: a rare cause of fetal scrotal cyst--MRI and pathologic appearance. Fetal Diagn Ther; 2009;26(1):38-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A full-term black boy presented at birth with an asymptomatic, 'stony-hard', scrotal mass suggestive of an in utero testicular torsion or testicular/paratesticular tumor.
  • Histology was consistent with the diagnosis of meconium periorchitis, a rare and benign condition resulting from healed intrauterine bowel perforation.
  • [MeSH-major] Intestinal Perforation / complications. Meconium. Orchitis / diagnosis. Scrotum / pathology

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  • [Copyright] 2009 S. Karger AG, Basel.
  • (PMID = 19816029.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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94. Albores-Saavedra J, Galliani C, Chable-Montero F, Batich K, Henson DE: Mucin-containing Rokitansky-Aschoff sinuses with extracellular mucin deposits simulating mucinous carcinoma of the gallbladder. Am J Surg Pathol; 2009 Nov;33(11):1633-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Detached fragments of biliary epithelium, small glands, and papillary structures lacking cytologic atypia and mitotic figures were identified in the abundant mucin deposits located in the subserosa of 3 cases.
  • The overlying surface gallbladder epithelium exhibited papillary hyperplasia with focal intestinal metaplasia in 2 patients, one of which had metachromatic leukodystrophy.
  • The lack of reactivity for carcinoembryonic antigen and p53 and the low proliferative activity as measured by MIB-1 labeling index provided additional support to the benign nature of the lesion.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology. Mucins / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Child, Preschool. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucous Membrane / metabolism. Mucous Membrane / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Jan;35(1):153-4 [21164300.001]
  • (PMID = 19738458.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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95. Sills ES, Doan TB, Mock RJ, Dixson GR, Rohlfing MB: Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. Diagn Pathol; 2006;1:28

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Endoscopy identified three benign intestinal tubular adenomas.
  • Following laparoscopic excision of the pelvic tumor immunohistochemical analysis of the mass showed negative staining for keratin, S100 protein, inhibin, calretinin, melan A, smooth muscle actin, CD34, CD117, and desmin.
  • CONCLUSION: Ovarian fibrothecomas represent an ovarian stromal neoplasm developing in a wide spectrum of clinical settings.

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  • (PMID = 16965622.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1570478
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96. Hart WR: Borderline epithelial tumors of the ovary. Mod Pathol; 2005 Feb;18 Suppl 2:S33-50
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Borderline epithelial tumors of the ovary.
  • The concept and terminology of borderline epithelial tumors of the ovary have been controversial for over a century, in spite of the acceptance of a borderline category in almost all current classifications of ovarian tumors.
  • Typically, borderline tumors are noninvasive neoplasms that have nuclear abnormalities and mitotic activity intermediate between benign and malignant tumors of similar cell type.
  • Borderline tumors of all surface epithelial cell types have been studied.
  • The most common and best understood are serous borderline tumors and mucinous borderline tumors of intestinal type, which are the subject of this review.
  • Some of the most challenging issues for serous tumors include: the criteria and clinical behavior of stromal microinvasion; the high prevalence of synchronous extraovarian disease; the classification and histopathologic features of associated peritoneal tumor implants, especially invasive implants; and, the prognostic significance of micropapillary tumors.
  • The mucinous borderline tumors of intestinal type have a different set of considerations, including: their frequently heterogeneous composition with coexisting benign, borderline and malignant elements; the classification and significance of accompanying noninvasive carcinoma; the recognition of stromal invasion, including microinvasion and expansile invasion; and, the historically misunderstood relationship to pseudomyxoma peritonei.
  • All of these issues are discussed in this presentation, as are the important gross and microscopic features of serous and mucinous borderline tumors and pertinent information on their treatment and prognosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 15761465.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 93
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97. McKenney JK, Soslow RA, Longacre TA: Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol; 2008 May;32(5):645-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei.
  • Mucinous epithelial neoplasms arising in association with mature teratomas are a heterogeneous group of tumors, but with the exception of a single recent study, their full histologic spectrum, detailed immunophenotype, and association with classic pseudomyxoma peritonei (PMP) have not been fully studied.
  • The morphologic, immunohistochemical, and clinical features of 42 patients with mucinous epithelial tumors arising in association with mature ovarian teratomas were evaluated.
  • Tumor size ranged from 5.5 to greater than 200 cm.
  • Most teratoma-associated mucinous tumors were unilateral, although 1 patient harbored bilateral mucinous tumors in association with bilateral teratomas.
  • Using the 2003 World Health Organization criteria for ovarian intestinal type mucinous neoplasms, 17 (40%) were classified as mucinous cystadenoma, 16 (38%) as intestinal-type mucinous epithelial neoplasm of low malignant potential (IM-LMP), 4 (10%) as intraepithelial carcinoma (IEC), and 5 (12%) as invasive mucinous carcinoma.
  • We report that a significant proportion of mucinous tumors associated with mature ovarian teratomas present with clinical PMP, which in most cases is associated with IM-LMP.
  • Pseudomyxoma ovarii is common in this setting, particularly in tumors with IM-LMP histology, but pseudomyxoma ovarii is not predictive of PMP.
  • Ovarian teratoma-associated benign and IM-LMP mucinous neoplasms with microscopic peritoneal low-grade mucinous epithelium do not seem to be at significant risk for intra-abdominal recurrence, but numbers are few and follow-up is limited.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology. Teratoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged. Mucins / metabolism. Neoplasms, Multiple Primary

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  • (PMID = 18344868.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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98. Nowicki MJ, Bishop PR, Subramony C, Wyatt-Ashmead J, May W, Crawford M: Colonic chicken-skin mucosa in children with polyps is not a preneoplastic lesion. J Pediatr Gastroenterol Nutr; 2005 Nov;41(5):600-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The association of CSM with benign juvenile polyps and the absence of histologic markers for increased replication and malignant transformation support the notion that this endoscopic finding is not preneoplastic.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology. Intestinal Mucosa / pathology. Ki-67 Antigen / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / analysis. Biopsy. Child. Child, Preschool. Colon / pathology. Colonoscopy. Female. Humans. Immunohistochemistry. Male. Prospective Studies

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  • (PMID = 16254516.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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99. Carinelli S, Motta F, Frontino G, Restelli E, Fedele L: Multiple extrauterine adenomyomas and uterus-like masses: case reports and review of the literature. Fertil Steril; 2009 May;91(5):1956.e9-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENT(S): Two patients without urogenital malformations diagnosed with extrauterine adenomyoma, which is a benign tumor composed of smooth muscle and endometrium, typically originating within the uterus.
  • [MeSH-major] Adenomyoma / pathology. Intestinal Neoplasms / pathology. Uterus / pathology

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  • (PMID = 19254794.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 33515-09-2 / Gonadotropin-Releasing Hormone
  • [Number-of-references] 19
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100. Jwo SC, Chien RN, Chao TC, Chen HY, Lin CY: Clinicopathological features, surgical management, and disease outcome of perforated gastric cancer. J Surg Oncol; 2005 Sep 15;91(4):219-25
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  • Disease outcomes were analyzed in-depth based on tumor stage, depth of tumor invasion, operative curability, and three treatment groups.
  • The remaining five patients were misdiagnosed as having benign gastric perforation and underwent local surgery; these patients were assigned to Group 3.
  • The survival rates for Stage I disease (P = 0.0342), T1/T2 tumors (P = 0.0342), and curative resection (P = 0.0012) significantly exceeded those of Stage III/IV, T3/T4 tumors, and non-curative resection.
  • [MeSH-major] Gastrectomy. Intestinal Perforation / etiology. Stomach / injuries. Stomach Neoplasms / complications. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Palliative Care. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16121341.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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