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1. Wolff C, Scholtz G: Cell lineage analysis of the mandibular segment of the amphipod Orchestia cavimana reveals that the crustacean paragnaths are sternal outgrowths and not limbs. Front Zool; 2006;3:19
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  • We discuss notable similarities of paragnath anlagen to those of the hypopharynx complex in myriapods and hexapods.
  • The fact that both structures grow out as two lateral buds in the same region of the mandibular sternite during development, and their important role in the formation of the feeding apparatus as a highly specialized chewing chamber in adults of crustaceans, myriapods, and hexapods argue for the paragnaths/hypopharynx anlagen being an additional potential apomorphy of Mandibulata.

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  • (PMID = 17144925.001).
  • [ISSN] 1742-9994
  • [Journal-full-title] Frontiers in zoology
  • [ISO-abbreviation] Front. Zool.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1702535
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2. Tishler RB, Posner MR, Norris CM Jr, Mahadevan A, Sullivan C, Goguen L, Wirth LJ, Costello R, Case M, Stowell S, Sammartino D, Busse PM, Haddad RI: Concurrent weekly docetaxel and concomitant boost radiation therapy in the treatment of locally advanced squamous cell cancer of the head and neck. Int J Radiat Oncol Biol Phys; 2006 Jul 15;65(4):1036-44
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  • Primary sites were: oropharynx 19, oral cavity 2, larynx/hypopharynx 5, and unknown primary 4.

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  • (PMID = 16682134.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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3. Vogelsang A, Schumacher B, Neuhaus H: Therapy of Zenker's diverticulum. Dtsch Arztebl Int; 2008 Feb;105(7):120-6
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  • Anatomically there is a loose bulge of the dorsal wall of the hypopharynx.

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  • (PMID = 19633762.001).
  • [ISSN] 1866-0452
  • [Journal-full-title] Deutsches Ärzteblatt international
  • [ISO-abbreviation] Dtsch Arztebl Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2696720
  • [Keywords] NOTNLM ; Zenker / Zenker and therapy / Zenker’s diverticulum
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4. Gurunathan RK, Panda NK, Das A, Karuppiah S: Thyroid gland in carcinoma of the larynx and hypopharynx: analysis of factors indicating thyroidectomy. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):435-9
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  • [Title] Thyroid gland in carcinoma of the larynx and hypopharynx: analysis of factors indicating thyroidectomy.
  • BACKGROUND: This prospective study analyzed the factors that could predict thyroid gland involvement in patients suffering from malignancy of the larynx and laryngopharynx.
  • METHODS: Fifty patients underwent total laryngectomy with either ipsilateral hemithyroidectomy or total thyroidectomy in cases with subglottic extent more than 1.5 cm or in patients undergoing total laryngopharyngectomy for hypopharyngeal malignancy.
  • RESULTS: The majority of patients had glottic involvement followed by supraglottic and hypopharyngeal lesions.
  • Our study showed a 2% incidence of thyroid gland invasion by tumour.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Thyroid Gland / pathology. Thyroidectomy / methods
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Laryngectomy / methods. Male. Middle Aged. Neoplasm Invasiveness. Pharyngectomy / methods. Prognosis. Prospective Studies. Risk Factors

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  • (PMID = 19128651.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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5. Protopappas AN, Chatziavramidis AM: Acute dysphagia after carp fish meal: a case report. MedGenMed; 2005;7(1):14
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  • Laboratory evaluation and fiber-optic examination of the upper aerodigestive tract was normal except for accumulation of saliva in the hypopharynx.

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  • (PMID = 16369319.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1681431
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6. Nishimura G, Tsukuda M, Horiuchi C, Satake K, Yoshida T, Nagao J, Kawakami M, Kondo N, Arai Y, Taguchi T, Matsuda H, Mikami Y: Concurrent chemoradiotherapy for T4 patients with hypopharyngeal and laryngeal squamous cell carcinomas. Auris Nasus Larynx; 2007 Dec;34(4):499-504
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  • [Title] Concurrent chemoradiotherapy for T4 patients with hypopharyngeal and laryngeal squamous cell carcinomas.
  • OBJECTIVES: Concurrent chemoradiotherapy (CCR) was given for the previously untreated T4 hypopharyngeal and laryngeal squamous cell carcinoma patients and the response and survival rates were evaluated.
  • PATIENTS AND METHODS: A total of 23 patients, namely, 15 for hypopharynx and 8 for larynx were eligible.
  • RESULTS: Ten out of the 15 hypopharyngeal carcinoma patients and 4 out of the 8 laryngeal carcinoma patients showed a complete response at the primary sites.
  • The 5-year disease-specific survival rate was 59.4% in all the patients, 51.9% in the hypopharyngeal carcinoma patients, and 71.0% in the laryngeal patients.
  • Seven out of the 12 resectable hypopharyngeal carcinoma patients and 4 out of 8 laryngeal carcinoma patients were able to do without total laryngectomy.
  • CONCLUSIONS: Based on these results, the survival rate in the hypopharyngeal and laryngeal T4 carcinoma patients treated by CCR seems to be satisfactory and the possibility of organ preservation for the advanced patients is indicated.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / drug therapy. Laryngeal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Combined Modality Therapy. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Humans. Laryngectomy. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Salvage Therapy

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  • (PMID = 17604583.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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7. Rodriguez-Pinilla M, Rodriguez-Peralto JL, Hitt R, Sanchez JJ, Sanchez-Verde L, Alameda F, Ballestin C, Sanchez-Cespedes M: beta-Catenin, Nf-kappaB and FAS protein expression are independent events in head and neck cancer: study of their association with clinical parameters. Cancer Lett; 2005 Dec 8;230(1):141-8
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  • In spite of much effort, no good markers have yet been found for predicting prognosis or response to therapy in advanced head and neck squamous cell carcinoma (HNSCCs) patients. beta-catenin, a protein involved in the cytoskeleton, cell-cell adhesion and gene transcription, is a factor associated with tumour progression.
  • Regarding clinical associations, tumours from the hypopharynx had significantly lower levels of beta-catenin expression than those from other locations (P<0.05).
  • [MeSH-major] Carcinoma, Squamous Cell / physiopathology. Head and Neck Neoplasms / physiopathology. NF-kappa B / biosynthesis. Receptors, Tumor Necrosis Factor / biosynthesis. beta Catenin / biosynthesis
  • [MeSH-minor] Antigens, CD95. Biomarkers, Tumor / analysis. Gene Expression Profiling. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Prognosis. Survival Analysis

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  • (PMID = 16253770.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Biomarkers, Tumor; 0 / FAS protein, human; 0 / NF-kappa B; 0 / Receptors, Tumor Necrosis Factor; 0 / beta Catenin
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8. Xiao Q, Hu GH, Zhong SX, Qian Y, Zeng Q, Hong SL: Reconstruction of hypopharynx and cervical oesophagus for treatment of advanced hypopharyngeal carcinoma and recurrent laryngeal carcinoma. Asian J Surg; 2010 Jan;33(1):14-9
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  • [Title] Reconstruction of hypopharynx and cervical oesophagus for treatment of advanced hypopharyngeal carcinoma and recurrent laryngeal carcinoma.
  • OBJECTIVE: To review our treatment strategy and outcomes in reconstructing the hypopharynx and cervical oesophagus with five techniques for advanced hypopharyngeal carcinoma and recurrent laryngeal carcinoma.
  • Defects of the hypopharynx and cervical oesophagus were reconstructed using the remaining laryngeal mucosa flap, pectoralis major myocutaneous flap, forearm free flap, jejunal free flap or latissimus dorsi myocutaneous flap.

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  • [Copyright] Copyright (c) 2010 Asian Surgical Association. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20497877.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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9. Jayaprakash V, Natarajan KK, Moysich KB, Rigual NR, Ramnath N, Natarajan N, Reid ME: Wood dust exposure and the risk of upper aero-digestive and respiratory cancers in males. Occup Environ Med; 2008 Oct;65(10):647-54
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  • METHODS: In a hospital-based case-control study conducted at Roswell Park Cancer Institute, Buffalo, NY, USA, an examination was carried out to determine the effect of self-reported WD exposure on 1522 male UADR cancer cases (241 oral and oropharyngeal, 90 nasal cavity, nasopharyngeal and hypopharyngeal, 124 laryngeal, 809 lung and tracheal and 258 oesophagus and gastric cardia) and 1522 male controls, frequency matched on age and smoking history.
  • WD was associated with an 82-93% increased risk of squamous cell, small cell and adenocarcinoma of the lung and more than twice the risk of developing squamous cell carcinoma of the nasal cavity, nasopharynx and hypopharynx, with a significant dose-response relationship.


10. Shahoon H, Kianbakht C: Symptomatic Elongated Styloid Process or Eagle's Syndrome: A Case Report. J Dent Res Dent Clin Dent Prospects; 2008;2(3):102-5
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  • Rarely, complete mineralization of the stylohyoid ligament or elongation of styloid process has been associated with difficulties in intubation and significant clinical symptoms, which is termed Eagle's syndrome, and it exhibits dull or sharp intermittent pain felt along the glossopharyngeal nerve that is located in the hypopharynx and at the base of the tongue and recurrent throat pain or foreign body sensation, dysphagia, or facial pain.

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  • (PMID = 23277855.001).
  • [ISSN] 2008-210X
  • [Journal-full-title] Journal of dental research, dental clinics, dental prospects
  • [ISO-abbreviation] J Dent Res Dent Clin Dent Prospects
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3532725
  • [Keywords] NOTNLM ; Eagle’s syndrome / elongated styloid process / stylocarotid syndrome
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11. Ozer F, Ozer C, Erkan AN, Yavuz H: [The therapeutic role and effectiveness of selective neck dissection in the management of N0 neck]. Kulak Burun Bogaz Ihtis Derg; 2009 Jul-Aug;19(4):192-7
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  • Seventy neck dissections in 58 patients (51 males, 7 females; mean age 63 years; range 21 to 85 years) in whom the primary site of the lesion was the larynx, oral cavity, oropharynx and hypopharynx, and who were considered to have N0 neck and to comply with the study criteria were included in the study.
  • Details were collected on tumor site and stage, type of surgery, pathologic N stage, number and size of pathologic nodes, extracapsular spread of nodes, postoperative radiotherapy, local recurrence, follow up time and survival status in all patients.
  • The most frequent site for primary tumor was larynx and most patients were at T2 stage.
  • [MeSH-minor] Adult. Aged. Female. Humans. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / radiography. Laryngeal Neoplasms / surgery. Male. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Young Adult

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  • (PMID = 19860633.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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12. Nishimura G, Sano D, Hanashi M, Yamanaka S, Tanigaki Y, Taguchi T, Horiuchi C, Matsuda H, Mikami Y, Tsukuda M: Myxofibrosarcoma of the hypopharynx. Auris Nasus Larynx; 2006 Mar;33(1):93-6
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  • [Title] Myxofibrosarcoma of the hypopharynx.
  • Hypopharyngeal myxofibrosarcoma has not been reported previously.
  • We report the first case of a patient with myxofibrosarcoma of the hypopharynx.
  • Sarcomas are rare in the hypopharynx, but we have to bear in mind their possibility.
  • [MeSH-major] Fibrosarcoma / pathology. Hypopharyngeal Neoplasms / pathology

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  • (PMID = 16183234.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Freeman SR, Keith AO, Aucott W, Kazmi N, Nigam A: Comparison between two valsalva techniques for improvement of hypopharyngeal nasendoscopy: a preliminary communication. Clin Otolaryngol; 2007 Dec;32(6):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison between two valsalva techniques for improvement of hypopharyngeal nasendoscopy: a preliminary communication.
  • OBJECTIVE: To compare the nasal valsalva with the trumpet manoeuvre and anterior neck skin traction as aids to nasendoscopic examination of the hypopharynx.
  • PARTICIPANTS: Twenty-six adult patients requiring hypopharyngeal nasendoscopic examination were recruited.
  • CONCLUSIONS: The nasal valsalva and the trumpet manoeuvre with anterior neck skin traction are complementary techniques for improving the view of the hypopharynx.
  • [MeSH-major] Hypopharynx. Laryngoscopy. Valsalva Maneuver

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  • (PMID = 18076441.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Letter; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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14. Taguchi T, Tsukuda M, Mikami Y, Matsuda H, Horiuchi C, Yoshida T, Nishimura G, Ishitoya J, Katori H: Concurrent chemoradiotherapy with cisplatin, 5-fluorouracil, methotrexate, and leucovorin in patients with advanced resectable squamous cell carcinoma of the larynx and hypopharynx. Acta Otolaryngol; 2006 Apr;126(4):408-13
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  • [Title] Concurrent chemoradiotherapy with cisplatin, 5-fluorouracil, methotrexate, and leucovorin in patients with advanced resectable squamous cell carcinoma of the larynx and hypopharynx.
  • In terms of larynx preservation, the present regimen appears to be useful for patients with advanced resectable squamous cell carcinoma (SCC) of the larynx and hypopharynx.
  • OBJECTIVES: To evaluate the efficacy and toxicity of concurrent chemoradiotherapy in patients with advanced resectable SCC of the larynx and hypopharynx, and to demonstrate the feasibility of larynx preservation.
  • RESULTS: The 3-year disease-specific survival rates of patients with laryngeal or hypopharyngeal SCC were 81.3% and 78%, respectively.
  • The 3-year disease-specific survival rates with larynx preservation of patients with laryngeal or hypopharyngeal SCC were 46.7% and 59%, respectively.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Hypopharynx. Laryngeal Neoplasms / drug therapy. Pharyngeal Neoplasms / drug therapy

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  • (PMID = 16608794.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 12001-76-2 / Vitamin B Complex; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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15. Mayer A, Andratschke M, Pauli C, Graefe H, Kristina K, Wollenberg B: Generation of an autologous cell system for immunotherapy of squamous cell carcinoma of the head and neck. Anticancer Res; 2005 Nov-Dec;25(6B):4075-80
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  • BACKGROUND: To date, there is no tumor antigen known to be sufficiently specific for diagnosis, therapy monitoring and immunotherapy of squamous cell carcinoma of the head and neck (SCCHN).
  • The aim of our study was to generate an autologous immune response against SCCHN in vitro for further characterization of SCCHN-specific tumor markers and adoptive immunotherapy.
  • MATERIALS AND METHODS: As sources for tumor antigens (Ags) for the restimulation of autologous immune cells, cell lines from solid SCCHN were established and characterized.
  • RESULTS: One primary cell line, SCCHN-GHD, newly established from a hypopharynx carcinoma, was further characterized as a telomerase-positive, immortalized cell line with epithelial cell characteristics.
  • CONCLUSION: This new SCCHN-GHD cell line is competent as a target for lysis by autologous immune cells and for the restimulation of autologous tumor-specific immune cells.
  • Subsequent characterization of tumor antigens will be performed.

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  • (PMID = 16309201.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-2; 0 / Recombinant Proteins
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16. Al-Shagahin H, Alkotyfan K, Müller HH, Sesterhenn AM, Werner JA: Cyfra 21-1 as a serum tumor marker for follow-up of patients with laryngeal and hypopharyngeal squamous cell carcinoma. Anticancer Res; 2009 Aug;29(8):3421-5
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  • [Title] Cyfra 21-1 as a serum tumor marker for follow-up of patients with laryngeal and hypopharyngeal squamous cell carcinoma.
  • AIM: To evaluate the importance and potential of Cyfra21-1 as a tumor marker (TM) for follow-up of patients with squamous cell carcinoma (SCC) in laryngeal and hypopharyngeal cancer.
  • PATIENTS AND METHODS: Cyfra21-1 serum levels of 50 patients with laryngeal and hypopharyngeal SCC were evaluated by ECLIA assay.
  • RESULTS: There was no significant correlation between Cyfra21-1 levels at the time of initial diagnosis and the clinicopathological parameters.
  • The clinical performance of Cyfra 21-1 as an individual tumor marker for follow-up of patients was good.
  • CONCLUSION: Cyfra 21-1 is not suitable for early diagnosis of SCC of the larynx and hypopharynx.
  • [MeSH-major] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Carcinoma, Squamous Cell / blood. Hypopharyngeal Neoplasms / blood. Keratin-19 / blood. Laryngeal Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / blood. Neoplasm Recurrence, Local / diagnosis. Neoplasm Staging. Prognosis. ROC Curve. Sensitivity and Specificity

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  • (PMID = 19661367.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / antigen CYFRA21.1
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17. Torres-Carranza E, Infante-Cossío P, Hernández-Guisado JM, Hens-Aumente E, Gutierrez-Pérez JL: Assessment of quality of life in oral cancer. Med Oral Patol Oral Cir Bucal; 2008 Nov;13(11):E735-41
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  • Quality of life (QL) in oral cancer patients has become one of the most important parameters to consider in the diagnosis and post-treatment follow-up.
  • Most of them assess all head and neck cancers, which conform to a heterogeneous group with several different features depending on location (oral cavity, oropharynx, larynx, hypopharynx, nasopharynx and salivary glands).
  • Most studies evaluate QL in short periods of time, normally within the first year after the diagnosis.
  • Data related with QL are mostly related to patient (age, sex, co-morbidity), tumour (location, size), and treatment (surgical treatment, radiotherapy association, reconstruction, cervical dissection, and/or feeding tube).

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  • (PMID = 18978717.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 34
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18. Bensadoun RJ, Bénézery K, Dassonville O, Magné N, Poissonnet G, Ramaïoli A, Lemanski C, Bourdin S, Tortochaux J, Peyrade F, Marcy PY, Chamorey E, Vallicioni J, Seng H, Alzieu C, Géry B, Chauvel P, Schneider M, Santini J, Demard F, Calais G: French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: Results at 2 years (FNCLCC-GORTEC). Int J Radiat Oncol Biol Phys; 2006 Mar 15;64(4):983-94
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  • BACKGROUND: Unresectable carcinomas of the oropharynx and hypopharynx still have a poor long-term prognosis.
  • Total tumor doses: 80.4 Gy/46 day (oropharynx), 75.6 Gy/44 day (hypopharynx).
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy / adverse effects. Combined Modality Therapy / methods. Dose Fractionation. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. France. Humans. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy. Hypopharyngeal Neoplasms / surgery. Male. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local. Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy. Oropharyngeal Neoplasms / surgery. Prospective Studies. Survival Analysis

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  • (PMID = 16376489.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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19. Muehlenberg K: [70-year-old patient with changes of the hypopharynx]. Dtsch Med Wochenschr; 2008 Dec;133(50):2619-20
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  • [Title] [70-year-old patient with changes of the hypopharynx].
  • [MeSH-major] Hypopharynx / pathology. Zenker Diverticulum / diagnosis

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  • (PMID = 19052997.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Cruz I, Mamel JJ, Brady PG, Cass-Garcia M: Incidence of abdominal wall metastasis complicating PEG tube placement in untreated head and neck cancer. Gastrointest Endosc; 2005 Nov;62(5):708-11; quiz 752, 753
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  • RESULTS: Of the 304 patients with head and neck cancer, 218 had active disease with a viable tumor in the oropharynx or hypopharynx at the time of PEG placement.
  • CONCLUSION: There is a small but definite risk for tumor implantation in the gastrostomy site when using the pull technique in patients with active head and neck cancer.
  • Careful assessment of the oropharynx and hypopharynx before PEG tube placement and the use of alternative techniques for enteral access in patients with untreated or residual malignancy are recommended to minimize this risk.
  • Use of other percutaneous techniques that do not involve traversing the hypopharynx with the catheter may help to prevent tumor translocation.
  • [MeSH-major] Abdominal Wall. Carcinoma, Squamous Cell / secondary. Enteral Nutrition. Gastrostomy / adverse effects. Head and Neck Neoplasms / therapy. Intubation, Gastrointestinal / adverse effects. Neoplasm Seeding

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  • [CommentIn] Gastrointest Endosc. 2006 Jun;63(7):1087 [16733142.001]
  • [CommentIn] Gastrointest Endosc. 2006 Apr;63(4):735-6 [16564898.001]
  • (PMID = 16246684.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Verduijn GM, Bartels LW, Raaijmakers CP, Terhaard CH, Pameijer FA, van den Berg CA: Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors. Int J Radiat Oncol Biol Phys; 2009 Jun 1;74(2):630-6
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  • [Title] Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors.
  • PURPOSE: To optimize the use of MRI for delineation of gross tumor volume for radiotherapy treatment planning purposes in hypopharyngeal and laryngeal tumors.
  • Feasibility of the definitive protocol was tested on patients with hypopharyngeal (n = 19) and laryngeal (n = 42) carcinoma.
  • CONCLUSIONS: High-resolution MR images of the hypopharynx and larynx can be obtained in the majority of patients using surface receiver coils in combination with the radiotherapy mask.
  • These MR images can be successfully used for tumor delineation in radiotherapy.
  • [MeSH-major] Clinical Protocols. Hypopharyngeal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Magnetic Resonance Imaging / methods. Tumor Burden

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  • (PMID = 19427562.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Elting LS, Keefe DM, Sonis ST, Garden AS, Spijkervet FK, Barasch A, Tishler RB, Canty TP, Kudrimoti MK, Vera-Llonch M, Burden of Illness Head and Neck Writing Committee: Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life. Cancer; 2008 Nov 15;113(10):2704-13
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  • RESULTS: Contrary to previous reports, the risk of mucositis was virtually identical in the 126 patients with oral cavity or oropharynx tumors (99% overall; 85% grade 3-4) compared with 65 patients with tumors of the larynx or hypopharynx (98% overall; 77% grade 3-4).

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  • (PMID = 18973181.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Antineoplastic Agents
  • [Investigator] Barasch A; Brennan M; Calais G; Canty T; Elting LS; Epstein J; Feyer P; Garden A; Grunberg SM; Keefe DM; Kudrimoti M; Molassiotis A; Oster G; Raber-Durlacher JE; Schultz C; Sonis ST; Spijkervet F; Tishler R; Trotti A; Vera-Llonch M
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23. Uria M, Kost K, Schricker T, Backman SB: Case report: nasotracheal intubation--look before leaping to assess the laryngeal view. Can J Anaesth; 2008 May;55(5):302-5
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  • An endotracheal tube was then guided through the right nostril into the hypopharynx.

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  • [CommentIn] Can J Anaesth. 2008 Sep;55(9):653; author reply 654-5 [18840597.001]
  • [CommentIn] Can J Anaesth. 2008 Sep;55(9):653-4; author reply 654-5 [18840596.001]
  • (PMID = 18451119.001).
  • [ISSN] 0832-610X
  • [Journal-full-title] Canadian journal of anaesthesia = Journal canadien d'anesthésie
  • [ISO-abbreviation] Can J Anaesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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24. Robbins KT, Kumar P, Harris J, McCulloch T, Cmelak A, Sofferman R, Levine P, Weisman R, Wilson W, Weymuller E, Fu K: Supradose intra-arterial cisplatin and concurrent radiation therapy for the treatment of stage IV head and neck squamous cell carcinoma is feasible and efficacious in a multi-institutional setting: results of Radiation Therapy Oncology Group Trial 9615. J Clin Oncol; 2005 Mar 1;23(7):1447-54
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  • PATIENTS AND METHODS: Eligibility included T4 squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx.
  • At a median follow-up of 3.9 years for alive patients (range, 0.9 to 6.1 years), the estimated 1-year and 2-year locoregional tumor control rates are 66% and 57%, respectively.

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  • (PMID = 15735120.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA-95-012
  • [Publication-type] Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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25. Asaoka D, Nagahara A, Oguro M, Izumi Y, Kurosawa A, Osada T, Kawabe M, Hojo M, Otaka M, Watanabe S: Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis. World J Gastroenterol; 2009 Jul 28;15(28):3480-5
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  • CONCLUSION: Mucosal inflammation extended to the upper esophagus close to the hypopharynx.

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  • (PMID = 19630101.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Diterpenes, Abietane; 2K02669KWP / ecabet
  • [Other-IDs] NLM/ PMC2715972
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26. Liu W, Gao Z, Ni D, Li W, Li Y, Wang H: [Dermatomyositis/polymyositis associated with head and neck malignancy]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Apr;19(8):340-1, 344
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  • RESULT: There were 17 cases of malignancy in 136 patients with dermatomyositis/polymyositis, of which, 6 cases (6/17, 35.29%) were found to have head-neck malignancy: 4 cases of nasopharyngeal carcinoma, 1 case of non-Hodgkin lymphoma and 1 case of hypopharynx carcinoma.
  • CONCLUSION: Nasopharyngeal carcinoma represents the first neoplasm among head-neck malignancy associated with dermatomyositis/polymyositis.
  • [MeSH-minor] Adult. Aged. Endoscopy. Female. Humans. Lymphoma, Non-Hodgkin / complications. Lymphoma, Non-Hodgkin / diagnosis. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16075982.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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27. Nemec SF, Formanek M, Noebauer-Huhmann IM, Krestan CR, Frühwald J, Peloschek P, Herneth AM, Czerny C: [Pathological changes of the hypopharynx in the focus of imaging]. Radiologe; 2009 Jan;49(1):36-42
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  • [Title] [Pathological changes of the hypopharynx in the focus of imaging].
  • [Transliterated title] Pathologische Veränderungen des Hypopharynx im Brennpunkt der Bildgebung.
  • The spectrum of pathological changes in anatomical sections of the hypopharynx ranges from benign pathologies to hypopharyngeal carcinoma.
  • Especially in radiological oncology, it is extremely important in regions which are clinically difficult to assess to determine the exact localization and extent of hypopharyngeal pathologies to plan the optimal therapy for the patient.
  • This article demonstrates the radiological appearance of pathological changes of the hypopharynx and discusses in particular the hypopharynx carcinoma in the focus of pre-therapeutic and post-therapeutic imaging.
  • [MeSH-major] Hypopharyngeal Neoplasms / diagnosis. Hypopharynx / pathology. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Pharyngeal Diseases / diagnosis. Positron-Emission Tomography
  • [MeSH-minor] Contrast Media / administration & dosage. Humans. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Tomography, Spiral Computed. Zenker Diverticulum / diagnosis. Zenker Diverticulum / pathology

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  • (PMID = 19023556.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 36
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28. Di Paolo M, Guidi B, Bruschini L, Vessio G, Domenici R, Ambrosino N: Unexpected delayed death after manual strangulation: need for careful examination in the emergency room. Monaldi Arch Chest Dis; 2009 Sep;71(3):132-4
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  • Flexible laryngoscopy failed to show any swelling of the hypopharynx or larynx.

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  • (PMID = 19999960.001).
  • [ISSN] 1122-0643
  • [Journal-full-title] Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
  • [ISO-abbreviation] Monaldi Arch Chest Dis
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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29. Sesterhenn AM, Fiedler G, Müller HH, Wiegand S, Folz BJ, Werner JA: Incidence of sinunasal disease in laryngectomized patients. ORL J Otorhinolaryngol Relat Spec; 2008;70(3):185-8
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  • OBJECTIVES: Patients having a total laryngectomy for cancer of the larynx or the hypopharynx are faced with tremendous physical and emotional challenges.
  • [MeSH-minor] Acute Disease. Aged. Aged, 80 and over. Chronic Disease. Common Cold / complications. Common Cold / epidemiology. Female. Follow-Up Studies. Humans. Hypopharyngeal Neoplasms / complications. Hypopharyngeal Neoplasms / surgery. Incidence. Laryngeal Neoplasms / complications. Laryngeal Neoplasms / surgery. Male. Middle Aged. Postoperative Period. Retrospective Studies. Sinusitis / complications. Sinusitis / epidemiology. Surveys and Questionnaires

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  • [Copyright] 2008 S. Karger AG, Basel
  • (PMID = 18391578.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
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30. Yi HL, Yin SK, Lu WY, Wu HM, Guan J, Cao ZY, Chen T: [Effectiveness of combined surgery for treating severe obstructive sleep apnea hypopnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Feb;41(2):89-94
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  • The obstruction in both the oropharynx and the hypopharynx were evaluated by preoperative physical examination, fiberoptic pharyngolaryngoscopy, cephalometry, and computed tomography of the upper airway.
  • CONCLUSIONS: GAHM plus UPPP is effective surgical approach for patients with severe OSAHS who suffer from oropharyngeal and hypopharyngeal obstruction.

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  • (PMID = 16671516.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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31. Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL: Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck; 2005 Oct;27(10):843-50
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  • METHODS: Both studies compared the addition of concomitant relatively high doses of cisplatin (on days 1, 22, and 43) to radiotherapy vs radiotherapy alone given after surgery in patients with high-risk cancers of the oral cavity, oropharynx, larynx, or hypopharynx.
  • CONCLUSIONS: Subject to the usual caveats of retrospective subgroup analysis, our data suggest that in locally advanced head and neck cancer, microscopically involved resection margins and extracapsular spread of tumor from neck nodes are the most significant prognostic factors for poor outcome.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Humans. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Risk. Survival Analysis

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 16161069.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5U10 CA11488; United States / NCI NIH HHS / CA / 5U10 CA11488-33
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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32. Ahlawat SK, Al-Kawas FH: Endoscopic management of upper esophageal strictures after treatment of head and neck malignancy. Gastrointest Endosc; 2008 Jul;68(1):19-24
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  • The primary tumor site was larynx in 10 patients, oropharynx or hypopharynx in 4 patients, upper esophagus in 4 patients, and other sites in the remainder.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Cohort Studies. Combined Modality Therapy. Deglutition / physiology. Deglutition Disorders / etiology. Deglutition Disorders / therapy. Female. Humans. Male. Middle Aged. Neck Dissection / adverse effects. Neck Dissection / methods. Postoperative Complications / diagnosis. Postoperative Complications / therapy. Prognosis. Radiotherapy, Adjuvant. Registries. Retrospective Studies. Risk Assessment. Treatment Outcome

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  • (PMID = 18355822.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Jiang M, Zhou M, Huang W, Li Z, Cheng X, Ji J, Xue F, Wang Q: [The study of resilience of oral pharyngeal wall in patients with obstructive sleep apnea hypopnea syndrome applied with multiple detector-row spiral CT]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Feb;21(3):97-9
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  • METHOD: Applied with multiple detector-row spiral CT, 24 patients with OSAHS and 10 volunteers were scanned from nasopharynx to hypopharynx under the normal breathing state and the breathing state of Muller maneuver.

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  • (PMID = 17441419.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Vaidya S, Pagare RS, Jethaliya SK, Sharma VK: Hydrogen peroxide as 'defogger' in indirect laryngoscopy. Indian J Otolaryngol Head Neck Surg; 2007 Sep;59(3):303-4
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  • Indirect laryngoscopy examination is a routine clinical procedure for visualizing larynx and hypopharynx.

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  • [Cites] J Otolaryngol. 1993 Oct;22(5):398 [8283512.001]
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  • (PMID = 23120461.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452115
  • [Keywords] NOTNLM ; Defogging agent / Hydrogen peroxide / Indirect laryngoscopy
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35. Latoo M, Lateef M, Khan M, Majid S, Islam MS, Ali J, Nawaz I, Ahmed S: Angiolipoma of hypopharynx: A diagnostic dilemma. Indian J Otolaryngol Head Neck Surg; 2007 Jun;59(2):176-7
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  • [Title] Angiolipoma of hypopharynx: A diagnostic dilemma.
  • We present a 48-year-old male with fibrovascular polyp of hypopharynx.
  • Diagnosis was established by barium swallow and oesophagoscopy.Transoral route was used to remove the polyp and histopathology reported as angiolipoma.

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  • (PMID = 23120425.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451778
  • [Keywords] NOTNLM ; Barium swallow / Fibrovascular polyp / Regurgitation / Videoendoscopy
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36. Allen AM, Haddad RI, Tishler RB: Retropharyngeal nodes in hypopharynx cancer on positron emission tomography. J Clin Oncol; 2007 Feb 10;25(5):599-601
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  • [Title] Retropharyngeal nodes in hypopharynx cancer on positron emission tomography.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Hypopharyngeal Neoplasms / radionuclide imaging. Lymph Nodes / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Aged. Fluorodeoxyglucose F18. Humans. Male. Neoplasm Staging. Pharynx. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 17290070.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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37. Bień S, Kamiński B, Zyłka S, Mezyk R, Piasta Z: Evolution of the epidemiology and clinical characteristics of larynx and hypopharynx carcinoma in Poland from 1991 to 2001. Eur Arch Otorhinolaryngol; 2008 Jul;265 Suppl 1:S39-46
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  • [Title] Evolution of the epidemiology and clinical characteristics of larynx and hypopharynx carcinoma in Poland from 1991 to 2001.
  • A retrospective analysis was performed of 12,888 cases of larynx and hypopharynx carcinoma diagnosed in 19 ENT Departments in Poland during an 11-year period from 1991 to 2001.
  • An assessment of basic epidemiological data, including also tumor site and disease stage at the time of diagnosis, was conducted.
  • Majority of cases (57.4%) presented with local advanced stage (T3+T4) carcinoma of the larynx and hypopharynx, with the highest rate (81.0%) for the pyriform sinus carcinomas, and with the lowest rate for glottic tumors (41.8%).
  • Distant metastases at the time of diagnosis were registered in 2.2% of the analyzed cases, with the highest percentage in the posterior pharyngeal wall (7.6%) and pyriform sinus (7.4%) carcinomas.
  • [MeSH-major] Hypopharyngeal Neoplasms / epidemiology. Laryngeal Neoplasms / epidemiology

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  • (PMID = 17955255.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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38. Nadig SK, Uppal S, Back GW, Coatesworth AP, Grace AR: Foreign body sensation in the throat due to displacement of the superior cornu of the thyroid cartilage: two cases and a literature review. J Laryngol Otol; 2006 Jul;120(7):608-9
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  • The most helpful diagnostic procedure was careful examination of the hypopharynx and neck and flexible fibre-optic rhinolaryngoscopy.
  • Although an uncommon finding, our experience is that symptoms due to a medially displaced thyroid cornu should be considered in the differential diagnosis as an important and surgically correctable cause of persistent foreign body sensation at the hyoid level in the neck.
  • [MeSH-major] Foreign Bodies / diagnosis. Laryngeal Diseases / diagnosis. Thyroid Cartilage
  • [MeSH-minor] Deglutition Disorders / etiology. Deglutition Disorders / surgery. Diagnosis, Differential. Esophagoscopy. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16681864.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 6
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39. Yom SS, Machtay M, Biel MA, Sinard RJ, El-Naggar AK, Weber RS, Rosenthal DI: Survival impact of planned restaging and early surgical salvage following definitive chemoradiation for locally advanced squamous cell carcinomas of the oropharynx and hypopharynx. Am J Clin Oncol; 2005 Aug;28(4):385-92
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  • [Title] Survival impact of planned restaging and early surgical salvage following definitive chemoradiation for locally advanced squamous cell carcinomas of the oropharynx and hypopharynx.
  • METHODS: A retrospective review was performed for patients with resectable T3/4 cancers of the oropharynx and hypopharynx treated with RT +/- chemotherapy who underwent planned restaging clinically, radiographically (CT or MRI), and by direct laryngoscopy with biopsy at 4 to 8 weeks post-RT.
  • Neck dissection was performed at time of restaging in patients with primary tumor control and initial N2/N3 neck disease or persistent lymphadenopathy.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Hypopharyngeal Neoplasms / mortality. Hypopharyngeal Neoplasms / pathology. Neoplasm Recurrence, Local / surgery. Oropharyngeal Neoplasms / mortality. Oropharyngeal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy / methods. Carboplatin / administration & dosage. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Laryngoscopy. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Palliative Care. Radiation Dosage. Radiation Injuries / epidemiology. Remission Induction. Retrospective Studies. Salvage Therapy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16062081.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; U3P01618RT / Fluorouracil
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40. Strek P, Oleś K, Składzień J, Tomik J, Gajec S, Kocoń S, Dutsch-Wicherek M, Hartwich P, Szaleniec J: [Quality of life in patients treated for cancer of paranasal sinus and other area at head and neck]. Przegl Lek; 2010;67(12):1298-301
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  • The primary location of the tumor was: paranasal sinuses, oral cavity, oropharynx, hypopharynx and larynx.
  • Patients with primary tumors of the oral cavity, oropharynx, hypopharynx and larynx had significantly greater swallowing disability with an adverse impact on their quality of life compared with patients after maxillectomy.
  • [MeSH-minor] Adult. Causality. Comorbidity. Female. Humans. Male. Middle Aged. Neoplasm Staging. Paranasal Sinus Neoplasms / epidemiology. Paranasal Sinus Neoplasms / pathology. Paranasal Sinus Neoplasms / therapy. Poland / epidemiology. Surveys and Questionnaires


41. Villaret AB, Piazza C, Peretti G, Calabrese L, Ansarin M, Chiesa F, Pellini R, Spriano G, Nicolai P: Multicentric prospective study on the prevalence of sublevel IIb metastases in head and neck cancer. Arch Otolaryngol Head Neck Surg; 2007 Sep;133(9):897-903
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  • OBJECTIVE: To evaluate the prevalence of sublevel IIB lymph node (LN) metastases for head and neck primary tumors in a large cohort of patients.
  • PATIENTS: Between 2003 and 2005, 297 patients (male to female ratio, 3.5:1; mean age, 58.8 years [range, 18-89 years]) affected by head and neck cancer were treated by surgery on the primary tumor and/or the neck.
  • Primary site distribution included the following: oral cavity in 111 patients, larynx in 92, oropharynx in 32, thyroid gland in 22, skin of the lateral face or scalp in 16, hypopharynx in 11, unknown primary in 7, and parotid gland in 6.
  • Tumor histologic type in the sublevel IIB+ population was squamous cell carcinoma in 80%, papillary carcinoma in 8%, melanoma in 8%, and adenocarcinoma in 4%.
  • The chi(2) test showed a significantly higher risk for LN metastases at sublevel IIB in patients affected by parotid gland primary tumors (33%), tumors of the skin or scalp (25%), unknown primary tumors (14%), and cancers of the oral cavity (10%) (P = .02) and in those clinically staged as cN+ (P < .001).
  • CONCLUSIONS: Sublevel IIB dissection is strongly recommended for all patients with cN+ tumors and in those affected by tumor of the parotid gland, skin, and scalp scheduled for elective ND.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Cross-Sectional Studies. Female. Humans. Lymph Node Excision. Male. Melanoma / epidemiology. Melanoma / pathology. Melanoma / surgery. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 17875856.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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42. Ozer E, Grecula JC, Agrawal A, Rhoades CA, Young DC, Schuller DE: Long-term results of a multimodal intensification regimen for previously untreated advanced resectable squamous cell cancer of the oral cavity, oropharynx, or hypopharynx. Laryngoscope; 2006 Apr;116(4):607-12
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  • [Title] Long-term results of a multimodal intensification regimen for previously untreated advanced resectable squamous cell cancer of the oral cavity, oropharynx, or hypopharynx.
  • BACKGROUND: Long-term disease control of an intensified treatment regimen for previously untreated stage III and IV resectable oral cavity, oropharyngeal, or hypopharyngeal squamous cell carcinoma was analyzed.
  • METHODS: Forty-three patients with previously untreated, advanced stage, resectable squamous carcinomas of the oral cavity, oropharynx, or hypopharynx were enrolled in a prospective phase II institutional clinical trial at a tertiary care National Cancer Institute-designated comprehensive cancer center.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / therapy. Mouth Neoplasms / therapy. Oropharyngeal Neoplasms / therapy. Otorhinolaryngologic Surgical Procedures / methods

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  • (PMID = 16585867.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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43. Uzun L, Ugur MB, Ulukent SC, Ozdemir H, Koca R: Vasculo-Behcet's disease mimicking a metastatic neck mass. Tohoku J Exp Med; 2005 May;206(1):81-4
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  • The mass was about four centimeters in diameter and extended to hypopharynx medially.
  • Biopsy from neck mass and hypopharynx revealed no specific pathology.
  • It is unusual for BD to present as a neck mass but yet it must be considered in the differential diagnosis of neck masses.
  • [MeSH-major] Behcet Syndrome / diagnosis. Behcet Syndrome / physiopathology
  • [MeSH-minor] Angiography. Carotid Artery, Common / radiography. Femoral Artery / radiography. Head and Neck Neoplasms / diagnosis. Humans. Male. Middle Aged. Neck / radiography. Neoplasm Metastasis / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 15802878.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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44. Korolkowa O, Osuch-Wójcikiewicz E: [Salvage surgery for advanced laryngeal and hypopharyngeal carcinoma]. Pol Merkur Lekarski; 2005 Sep;19(111):365-7
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  • [Title] [Salvage surgery for advanced laryngeal and hypopharyngeal carcinoma].
  • The aim of this study was to present results of treatment of advanced laryngeal and hypopharyngeal carcinoma in 334 patients, who were treated by primary radiotherapy and salvage surgery in Department of Otolaryngology of the Medical University of Warsaw between 1975 and 1990.
  • Cancer of the larynx was diagnosed in 295 cases and cancer of hypopharynx in 39 cases.
  • Depending on the extend of the tumor different types of surgery were performed.
  • The 3-years survival after treatment without recurrence of the disease was:--among patients with laryngeal cancer: 56% (167 patients)--among patients with hypopharyngeal cancer: 38% (15 patients).
  • [MeSH-major] Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / surgery. Salvage Therapy
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Treatment Outcome

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  • (PMID = 16358872.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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45. Sanabria A, Carvalho AL, Vartanian JG, Magrin J, Ikeda MK, Kowalski LP: Factors that influence treatment decision in older patients with resectable head and neck cancer. Laryngoscope; 2007 May;117(5):835-40
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  • METHODS: Patients of 70 years of age of older with diagnosis of resectable head and neck cancer were included.
  • Associated factors related to selection of substandard treatment were higher age, oro/hypopharynx tumor site, severe comorbidity, advanced clinical stage, and low Karnofsky Index.
  • Selecting substandard treatment for reasons such as chronologic age, tumor site, or moderate or mild comorbidities worsen patient prognosis.

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  • (PMID = 17473679.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Jaswal A, Haldar A, Biswas G, Sikder B, Nandi T: Giant fibrolipoma of the hypopharynx: a rare presentation. J Otolaryngol Head Neck Surg; 2010 Feb;39(1):E1-3
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  • [Title] Giant fibrolipoma of the hypopharynx: a rare presentation.
  • [MeSH-major] Fibroma / pathology. Fibroma / surgery. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Lipoma / pathology. Lipoma / surgery
  • [MeSH-minor] Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 20122336.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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47. Hammami B, Mnejja M, Kallel S, Bouguecha L, Chakroun A, Charfeddine I, Ghorbel A: Hypopharyngeal amyloidosis: A case report. Eur Ann Otorhinolaryngol Head Neck Dis; 2010 May;127(2):83-5
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  • [Title] Hypopharyngeal amyloidosis: A case report.
  • Hypopharyngeal amyloidosis is rare.
  • We report a case of hypopharyngeal amyloidosis and review the characteristics of this exceptional pathology.
  • Panendoscopy found regular swelling of the posterior wall of the hypopharynx and cervical esophagus.
  • Cervical CT and MRI showed thickening of the posterior wall of the hypopharynx.
  • Biopsy found amorphous acellular eosinophil interstitial deposits, shown to be amyloid on Congo red staining, leading to a diagnosis of amyloidosis.
  • Hypopharyngeal involvement is exceptional.
  • Diagnosis is histological.
  • [MeSH-major] Amyloidosis. Hypopharynx. Pharyngeal Diseases

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  • [Copyright] Copyright © 2010. Published by Elsevier Masson SAS.
  • (PMID = 20822762.001).
  • [ISSN] 1879-730X
  • [Journal-full-title] European annals of otorhinolaryngology, head and neck diseases
  • [ISO-abbreviation] Eur Ann Otorhinolaryngol Head Neck Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
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48. Steffen A, Graefe H, Gehrking E, König IR, Wollenberg B: Sleep apnoea in patients after treatment of head neck cancer. Acta Otolaryngol; 2009 Nov;129(11):1300-5
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  • The possible importance of tumour treatment features, especially transient tracheostoma, needs further assessment.
  • This study was undertaken to assess the prevalence of sleep apnoea in head and neck cancer patients by characterizing their clinical, anatomical and tumour treatment features.
  • Subjects positive for sleep apnoea more often had a tumour of the hypopharynx or larynx and more often had a transient tracheostoma during cancer therapy.
  • [MeSH-minor] Aged. Cross-Sectional Studies. Female. Humans. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Oropharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / surgery. Polysomnography. Prospective Studies. Risk Factors. Tracheotomy

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  • (PMID = 19863328.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Conway DI: Each portion of fruit or vegetable consumed halves the risk of oral cancer. Evid Based Dent; 2007;8(1):19-20
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  • 2) the primary outcome was clearly defined as cancers of the mouth, pharynx and hypopharynx (as defined by codes 141, 143-146,148 and 149 of the ninth revision of the International Classification of Diseases or other classifications that included these sites);.

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  • [CommentOn] Am J Clin Nutr. 2006 May;83(5):1126-34 [16685056.001]
  • (PMID = 17380179.001).
  • [ISSN] 1462-0049
  • [Journal-full-title] Evidence-based dentistry
  • [ISO-abbreviation] Evid Based Dent
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
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50. Lucioni M, Marioni G, Della Libera D, Rizzotto G: Adult laryngeal hemangioma CO2 laser excision. A single institution 3-year experience (Vittorio Veneto 2001-2003). Acta Otolaryngol; 2006 Jun;126(6):621-6
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  • Extended laryngeal cavernous hemangiomas involving hypopharynx should be approached with staged CO2 laser surgical procedures.
  • OBJECTIVES: Hemangioma of the adult larynx is an uncommon, benign lesion characterized by thin, friable mucosa overlying the vascular stroma.

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  • (PMID = 16720447.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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51. Schouten LJ, Hogervorst JG, Konings EJ, Goldbohm RA, van den Brandt PA: Dietary acrylamide intake and the risk of head-neck and thyroid cancers: results from the Netherlands Cohort Study. Am J Epidemiol; 2009 Oct 1;170(7):873-84
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  • After 16.3 years of follow-up, there were 101, 83, 180, and 66 cases of oral cavity, oro-hypopharynx, larynx, and thyroid cancer, respectively.
  • Dietary acrylamide intake was not associated with increased risk of oral cavity (hazard ratio (HR) per 10-microg intake/day = 0.90, 95% confidence interval (CI): 0.73, 1.10), oro-hypopharynx (HR = 0.74, 95% CI: 0.53, 1.03), larynx (HR = 1.05, 95% CI: 0.91, 1.21), or thyroid (HR = 1.03, 95% CI: 0.82, 1.27) cancer.

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  • (PMID = 19720866.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylamides; 0 / Food Additives
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52. Hayashi R: [The management for superficial carcinoma in the oropharynx and hypopharynx]. Nihon Shokakibyo Gakkai Zasshi; 2009 Sep;106(9):1287-90
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  • [Title] [The management for superficial carcinoma in the oropharynx and hypopharynx].
  • [MeSH-major] Carcinoma / surgery. Hypopharyngeal Neoplasms / surgery. Oropharyngeal Neoplasms / surgery

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  • (PMID = 19734698.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 23
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53. Medina JA, Rueda A, de Pasos AS, Contreras J, Cobo M, Moreno P, Benavides M, Villanueva A, Alba E: A phase II study of concomitant boost radiation plus concurrent weekly cisplatin for locally advanced unresectable head and neck carcinomas. Radiother Oncol; 2006 Apr;79(1):34-8
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  • MATERIAL AND METHODS: A total of 94 patients (median age, 58 years) with UICC stage III (n = 19) and IV (n = 75) cancer of the oropharynx, larynx, hypopharynx and oral cavity were included.

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  • (PMID = 16626826.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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54. Bruzgielewicz A, Hamera M, Osuch-Wójcikiewicz E: [Nutritional status of patients with cancer of larynx and hypopharyx]. Otolaryngol Pol; 2009 Mar-Apr;63(2):141-6
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  • The aim of this study was to evaluate nutritional status of patients with cancer of larynx and hypopharynx before the treatment.
  • MATERIAL AND METHOD: 223 men and 29 women with diagnosed squamous cell cancer of larynx and hypopharynx, who were classified to surgical treatment, were included into study.
  • The evaluated population was divided into groups depending on location and local extend of the tumor.
  • The level of malnutrition increases while increases stage of local extend of tumor.
  • The least numerous group of malnutritioned patients were those with tumor of glottis, but also in this group was the largest percentage of patients with local extend of tumor: T1 and T2.
  • The state of considerable malnutrition was diagnosed in 34% patients with tumor of the piriform recess.
  • In the group with tumor of glottis and epiglottis the level of malnutrition increases while increases stage of local extend of tumor.
  • All the patients with tumor T4 with unclassified origin location were classified to the group of malnutritioned.
  • CONCLUSIONS: The malnutrition is diagnosed in considerable percentage of patients with cancer of larynx and hypopharynx.
  • The diagnosis of poor nutritional state will permit to apply suitable, controlled nutrition before surgical treatment.
  • [MeSH-major] Hypopharyngeal Neoplasms / epidemiology. Laryngeal Neoplasms / epidemiology. Malnutrition / epidemiology. Nutrition Assessment. Nutritional Status. Preoperative Care / statistics & numerical data
  • [MeSH-minor] Adult. Aged. Body Mass Index. Body Weight. Female. Humans. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Risk Factors

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  • (PMID = 19681485.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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55. Pointreau Y, Garaud P, Chapet S, Sire C, Tuchais C, Tortochaux J, Faivre S, Guerrif S, Alfonsi M, Calais G: Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. J Natl Cancer Inst; 2009 Apr 1;101(7):498-506
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  • BACKGROUND: Chemotherapy with cisplatin (P) and 5-fluorouracil (F) followed by radiotherapy in patients who respond to chemotherapy is an alternative to total laryngectomy for patients with locally advanced larynx and hypopharynx cancer.
  • METHODS: Patients who had larynx and hypopharynx cancer that required total laryngectomy were randomly assigned to receive three cycles of TPF or PF.
  • RESULTS: Baseline patient and tumor characteristics were well balanced between the TPF (n = 110) and PF (n = 103) groups.
  • CONCLUSIONS: In patients with advanced larynx and hypopharynx carcinomas, TPF induction chemotherapy was superior to the PF regimen in terms of overall response rate.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / drug therapy. Laryngeal Neoplasms / surgery. Laryngectomy / methods. Neoadjuvant Therapy / methods

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  • [CommentIn] J Natl Cancer Inst. 2009 Aug 19;101(16):1157-8; author reply 1158 [19567423.001]
  • (PMID = 19318632.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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56. Negri E, Boffetta P, Berthiller J, Castellsague X, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, Lazarus P, Lence JJ, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AF, Rudnai P, Shangina O, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Lissowska J, Zhang ZF, Ferro G, Brennan P, La Vecchia C, Hashibe M: Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Int J Cancer; 2009 Jan 15;124(2):394-401
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  • The risk was higher when the affected relative was a sibling (OR=2.2, 95% CI 1.6-3.1) rather than a parent (OR=1.5, 95% CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx).

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  • [Copyright] Copyright (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18814262.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50CA90388; United States / NCI NIH HHS / CA / R01CA100264; United States / NIEHS NIH HHS / ES / P30 ES010126; United States / NCI NIH HHS / CA / P01 CA068384; United States / NIDA NIH HHS / DA / R01 DA011386; United States / NIEHS NIH HHS / ES / R01 ES011740; United States / NCI NIH HHS / CA / K07 CA104231; United States / NCI NIH HHS / CA / R01CA61188; United States / NCI NIH HHS / CA / P01CA068384; United States / NIEHS NIH HHS / ES / R21ES011667; United States / NCI NIH HHS / CA / T32 CA009142; United States / NCI NIH HHS / CA / U01 CA096134; United States / NCI NIH HHS / CA / U01CA96134; United States / NCI NIH HHS / CA / R03 CA077954; United States / NIEHS NIH HHS / ES / R21 ES011667; United States / NIEHS NIH HHS / ES / R01ES11740; United States / NCI NIH HHS / CA / R03 CA113157; United States / NCI NIH HHS / CA / R03CA77954; United States / NIDA NIH HHS / DA / R01DA11386; United States / NICHD NIH HHS / HD / R24 HD050924; United States / NCI NIH HHS / CA / K07CA104231; United States / NIEHS NIH HHS / ES / P30ES010126; United States / NCI NIH HHS / CA / T32CA09142; United States / NCI NIH HHS / CA / R01 CA100264; United States / NCI NIH HHS / CA / P50 CA090388
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS407434; NLM/ PMC3711193
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57. Satyanarayana L, Asthana S: Life time risk for development of ten major cancers in India and its trends over the years 1982 to 2000. Indian J Med Sci; 2008 Feb;62(2):35-44
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  • Among males, significant (P<0.05) increasing trends wre observed for NHL and prostate cancer; whereas declining trends were observed for stomach, liver, hypopharynx and tongue cancers.

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  • (PMID = 18319530.001).
  • [ISSN] 0019-5359
  • [Journal-full-title] Indian journal of medical sciences
  • [ISO-abbreviation] Indian J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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58. van den Broek GB, Rasch CR, Pameijer FA, Peter E, van den Brekel MW, Balm AJ: Response measurement after intraarterial chemoradiation in advanced head and neck carcinoma: magnetic resonance imaging and evaluation under general anesthesia? Cancer; 2006 Apr 15;106(8):1722-9
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  • METHODS: Eighty-two consecutive patients with advanced-stage squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or supraglottic larynx were treated with selective targeted chemoradiation.
  • The diagnosis of treatment failure was based on tissue biopsies, which were obtained during EGA or later during follow-up.
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Female. Humans. Infusions, Intra-Arterial. Male. Neoplasm, Residual / pathology. Predictive Value of Tests

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  • [Copyright] 2006 American Cancer Society
  • (PMID = 16544314.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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59. Tse GM, Yu KH, Chan AW, King AD, Chen GG, Wong KT, Tsang RK, Chan AB: HER2 expression predicts improved survival in patients with cervical node-positive head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg; 2009 Oct;141(4):467-73
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  • STUDY DESIGN: A case review of 186 HNSCCs from the oral tongue, palate, maxillary sinus, floor of mouth, oropharynx, hypopharynx, and larynx.
  • SUBJECTS AND METHODS: All primary tumor specimens were evaluated by immunohistochemistry for HER2 and p63 expressions, which were correlated with clinical parameters including age, sex, grade, lymph node metastases, stage, and survival.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / mortality. Head and Neck Neoplasms / mortality. Receptor, ErbB-2 / analysis
  • [MeSH-minor] Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck. Prognosis. Survival Analysis. Survival Rate. Trans-Activators / analysis. Transcription Factors. Tumor Suppressor Proteins / analysis

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  • (PMID = 19786214.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; EC 2.7.10.1 / Receptor, ErbB-2
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60. Gould L, Lewis S: Care of head and neck cancer patients with swallowing difficulties. Br J Nurs; 2006 Nov 9-22;15(20):1091-6
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  • Cancers of the head and neck include oral cavity, oropharynx, hypopharynx, nasopharynx, larynx, nasal fossa, paranasal sinuses, thyroid, salivary glands and vermilion surfaces (Parker et al, 2004).
  • At time of diagnosis patients often present with swallowing difficulties due to tumour location and size.

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  • (PMID = 17170655.001).
  • [ISSN] 0966-0461
  • [Journal-full-title] British journal of nursing (Mark Allen Publishing)
  • [ISO-abbreviation] Br J Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 19
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61. Seitz HK, Maurer B, Stickel F: Alcohol consumption and cancer of the gastrointestinal tract. Dig Dis; 2005;23(3-4):297-303
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  • Epidemiological data have identified chronic alcohol consumption as a significant risk factor for upper gastrointestinal cancer (oropharynx, hypopharynx, esophagus) and colorectal cancer.
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Male. Neoplasm Staging. Prevalence. Prognosis. Risk Assessment. Survival Analysis

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 16508294.001).
  • [ISSN] 0257-2753
  • [Journal-full-title] Digestive diseases (Basel, Switzerland)
  • [ISO-abbreviation] Dig Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 1.14.13.- / Cytochrome P-450 CYP2E1; EC 1.2.1.3 / Aldehyde Dehydrogenase
  • [Number-of-references] 62
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62. Krstevska V, Crvenkova S: Altered and conventional fractionated radiotherapy in locoregional control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, and hypopharynx. Croat Med J; 2006 Feb;47(1):42-52
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  • [Title] Altered and conventional fractionated radiotherapy in locoregional control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, and hypopharynx.
  • AIM: To compare the efficacy of two altered fractionation radiotherapy treatment protocols (hyperfractionation and accelerated fractionation with concomitant boost) with conventional fractionation in improvement of locoregional disease control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, or hypopharynx.
  • METHODS: From March 1999 to December 2000, 51 patients with previously untreated squamous cell carcinoma of the larynx, oropharynx or hypopharynx underwent conventionally fractionated radiotherapy and received 66-70 Gy in 6(1/2)-7 weeks (2 Gy per fraction a day, 5 fractions a week).
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / radiotherapy. Oropharyngeal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiation Injuries. Radiotherapy Dosage. Survival Rate

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  • (PMID = 16489696.001).
  • [ISSN] 1332-8166
  • [Journal-full-title] Croatian medical journal
  • [ISO-abbreviation] Croat. Med. J.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00291434
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
  • [Other-IDs] NLM/ PMC2080358
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63. Fujii S: [Pathology of superficial type squamous cell carcinoma of the oropharynx and hypopharynx]. Nihon Shokakibyo Gakkai Zasshi; 2009 Sep;106(9):1306-12
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  • [Title] [Pathology of superficial type squamous cell carcinoma of the oropharynx and hypopharynx].
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hypopharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / pathology

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  • (PMID = 19734701.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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64. Derks W, de Leeuw JR, Hordijk GJ, Winnubst JA: Reasons for non-standard treatment in elderly patients with advanced head and neck cancer. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):21-6
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  • This study assessed the influence that age, tumour characteristics, comorbidity, social support, depressive symptoms and quality of life have on treatment choice.
  • One hundred and five patients between 45 and 60 years of age and 78 patients of > or =70 years of age with carcinoma of the oral cavity (stage > or =II), oro- and hypopharynx (stage > or =II) or larynx (stage > or =III) completed a questionnaire on quality of life (EORTC QLQ-C30 and H&N35), depressive symptoms (CES-D) and social support (RSS12-I).
  • A multivariate logistic regression analysis showed that the following factors predicted non-standard treatment: marital status (widowed), advanced tumour stage, comorbidity, less pain, considering the length of life less important than its quality and old age.
  • [MeSH-minor] Aged. Depression / etiology. Female. Humans. Hypopharyngeal Neoplasms / psychology. Hypopharyngeal Neoplasms / therapy. Laryngeal Neoplasms / psychology. Laryngeal Neoplasms / therapy. Male. Middle Aged. Neoplasm Staging. Oropharyngeal Neoplasms / psychology. Oropharyngeal Neoplasms / therapy. Quality of Life. Social Support. Surveys and Questionnaires

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  • (PMID = 15014947.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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65. Ringash J, Lockwood G, O'Sullivan B, Warde P, Bayley A, Cummings B, Kim J, Sellmann S, Waldron J: Hyperfractionated, accelerated radiotherapy for locally advanced head and neck cancer: quality of life in a prospective phase I/II trial. Radiother Oncol; 2008 May;87(2):181-7
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  • MATERIALS AND METHODS: Patients with squamous cell HNC (TNM stage III/IV larynx or pharynx, or hypopharynx any stage) received 40 fractions of twice daily RT at 3 dose levels: (L1) 60Gy, 1.5Gy/fraction;.
  • QOL improved significantly with time from diagnosis, however post-treatment QOL was lower and improved more slowly in patients who had feeding tubes.

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  • (PMID = 18215435.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
  • [Publication-country] Ireland
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66. Zhang X, Chen Y, Wang J, Xie G, Pan X, Li M, Xu F, Yu D: [The application of multi-slice computed tomograph in diagnosis and operation of hypopharyngeal carcinoma]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Feb;20(3):101-4
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  • [Title] [The application of multi-slice computed tomograph in diagnosis and operation of hypopharyngeal carcinoma].
  • OBJECTIVE: To evaluate the clinical application of multi slice CT(MSCT) in hypopharyngeal carcinoma and serve otolaryngologist to institute proper operation.
  • METHOD: Forty-five patients with hypopharyngeal carcinoma scanned by MSCT were studied and confirmed by operation and pathologic examination.
  • RESULT: Of 45 cases, 34 cases derived from piriform fossa, 7 cases were from the postcricoid region and 4 cases were in the posterior wall of hypopharynx.
  • The tumor showed isodense or mixed density and slightly enhancement, piriform fossa became narrow or disappeared, retropharyngeal soft tissue thickened, laryngeal cartilage and esophageal ostium were invaded and lymph nodes of neck became metastasis.
  • The tumor pushed the annular and arytenoids cartilage displacement anteriorly; the thyroid arytenoidal gap and cricothyroid joint were widened.
  • [MeSH-major] Carcinoma, Squamous Cell / radiography. Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / radiography. Hypopharyngeal Neoplasms / surgery

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  • (PMID = 16646398.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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67. Caglar HB, Tishler RB, Othus M, Burke E, Li Y, Goguen L, Wirth LJ, Haddad RI, Norris CM, Court LE, Aninno DJ, Posner MR, Allen AM: Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys; 2008 Nov 15;72(4):1110-8
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  • The primary site of cancer was the oropharynx in 43, hypopharynx/larynx in 17, oral cavity in 13, nasopharynx in 11, maxillary sinus in 2, and unknown primary in 10.

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  • (PMID = 18468812.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA009337
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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68. Gupta S, Kong W, Peng Y, Miao Q, Mackillop WJ: Temporal trends in the incidence and survival of cancers of the upper aerodigestive tract in Ontario and the United States. Int J Cancer; 2009 Nov 1;125(9):2159-65
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  • Smaller increases in survival were observed in cancers of the oral cavity, nasopharynx, and hypopharynx, but there was no evidence of any increase in survival for cancer of the larynx.

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  • [Copyright] (c) 2009 UICC.
  • (PMID = 19569190.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Doeltgen SH, Witte U, Gumbley F, Huckabee ML: Evaluation of manometric measures during tongue-hold swallows. Am J Speech Lang Pathol; 2009 Feb;18(1):65-73
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  • METHOD: Pharyngeal pressures from 40 young, healthy individuals (mean age = 25.8 years, gender equally distributed) were recorded at 3 locations: oropharynx, hypopharynx, and upper esophageal sphincter (UES), during normal control and tongue-hold swallows.
  • Between sensors, peak pressure was lower and pressure slopes were steeper in the hypopharynx compared to the oropharynx.

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  • [CommentIn] Am J Speech Lang Pathol. 2011 May;20(2):124-30 [21386045.001]
  • (PMID = 18845700.001).
  • [ISSN] 1058-0360
  • [Journal-full-title] American journal of speech-language pathology
  • [ISO-abbreviation] Am J Speech Lang Pathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Dobler B, Weidner K, Koelbl O: Application of volumetric modulated arc therapy (VMAT) in a dual-vendor environment. Radiat Oncol; 2010;5:95
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  • VMAT planning was conducted for three typical target types of prostate cancer, hypopharynx/larynx cancer and vertebral metastases, and compared to standard IMRT with respect to plan quality, number of monitor units (MU), and treatment time.
  • For treatment of the hypopharynx/larynx cancer, a second arc was necessary to achieve sufficient plan quality.
  • [MeSH-major] Bone Neoplasms / radiotherapy. Hypopharyngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy / methods. Radiotherapy Planning, Computer-Assisted / methods


71. Tilly N, Johansson J, Isacsson U, Medin J, Blomquist E, Grusell E, Glimelius B: The influence of RBE variations in a clinical proton treatment plan for a hypopharynx cancer. Phys Med Biol; 2005 Jun 21;50(12):2765-77
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  • [Title] The influence of RBE variations in a clinical proton treatment plan for a hypopharynx cancer.
  • The treatment plan is evaluated by RBE weighted dose volume histograms (DVHs) and the calculation of tumour control probability (TCP) and normal tissue complication probability (NTCP) values.
  • The variable RBE correction yields DVHs for the clinical target volumes (CTVs), a primary advanced hypopharynx cancer and subclinical disease in the lymph nodes, that are slightly higher than those achieved by multiplying the absorbed dose with RBE=1.1.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / radiotherapy. Protons / therapeutic use

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  • (PMID = 15930601.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protons
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72. Cook MB, Dawsey SM, Freedman ND, Inskip PD, Wichner SM, Quraishi SM, Devesa SS, McGlynn KA: Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev; 2009 Apr;18(4):1174-82
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  • RESULTS: The 10 cancers with the largest male-to-female IRR were Kaposi sarcoma (28.73), lip (7.16), larynx (5.17), mesothelioma (4.88), hypopharynx (4.13), urinary bladder (3.92), esophagus (3.49), tonsil (3.07), oropharynx (3.06), and other urinary organs (2.92).

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  • (PMID = 19293308.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA CP010126-15
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS160092; NLM/ PMC2793271
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73. Zhang B, Yamada A: [Donor site choice for free flaps in head and neck reconstruction after tumor surgery]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2005 Oct;19(10):777-9
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  • [Title] [Donor site choice for free flaps in head and neck reconstruction after tumor surgery].
  • OBJECTIVE: To choose suitable free flaps for reconstructing head and neck defects caused by tumor resection.
  • The head and neck defects were caused by tumor resection.
  • The locations were oral cavity (n=32), hypopharynx (n=27), mandible (n=12), skull base (n=5), scalp and skin (n=6) and midface (n=4).
  • Of 27 hypopharyngeal defects, 25 were restored by jejunum flaps (93%).

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  • (PMID = 16274121.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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74. Chan AS, Lee RW, Srinivasan VK, Darendeliler MA, Grunstein RR, Cistulli PA: Nasopharyngoscopic evaluation of oral appliance therapy for obstructive sleep apnoea. Eur Respir J; 2010 Apr;35(4):836-42
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  • Mandibular advancement caused an increase in the calibre of the velopharynx (mean+/- sem +40+/-10%), with relatively minor changes occurring in the oropharynx and hypopharynx.
  • When the Müller manoeuvre was performed with mandibular advancement, airway collapse was greater in nonresponders than responders in the velopharynx (-80+/-11% versus +9+/-37%; p<0.001), oropharynx (-36+/-6% versus -20+/-5%; p<0.05) and hypopharynx (-64+/-6% versus -42+/-6%; p<0.05).
  • [MeSH-minor] Adult. Aged. Female. Humans. Hypopharynx / pathology. Hypopharynx / physiopathology. Logistic Models. Male. Middle Aged. Observer Variation. Oropharynx / pathology. Oropharynx / physiopathology. Polysomnography. Predictive Value of Tests. Supine Position. Wakefulness

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  • (PMID = 19797130.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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75. Koiwai K, Shikama N, Sasaki S, Shinoda A, Kadoya M: Risk factors for severe Dysphagia after concurrent chemoradiotherapy for head and neck cancers. Jpn J Clin Oncol; 2009 Jul;39(7):413-7
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  • The locations of the primary lesion were as follows: larynx in 18 patients, oropharynx in 11, nasopharynx in 7, hypopharynx in 7 and others in 4.
  • In univariate analysis, clinical stage (III-IV) (P = 0.017), primary site (oro-hypopharynx) (P = 0.041) and radiation portal size (>11 cm) (P < 0.001) were found to be associated with severe dysphagia.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / secondary. Cisplatin / administration & dosage. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Risk Factors. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19383615.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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76. Galeone C, Tavani A, Pelucchi C, Turati F, Winn DM, Levi F, Yu GP, Morgenstern H, Kelsey K, Dal Maso L, Purdue MP, McClean M, Talamini R, Hayes RB, Franceschi S, Schantz S, Zhang ZF, Ferro G, Chuang SC, Boffetta P, La Vecchia C, Hashibe M: Coffee and tea intake and risk of head and neck cancer: pooled analysis in the international head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev; 2010 Jul;19(7):1723-36
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  • This latter estimate was consistent for different anatomic sites (OR, 0.46; 95% CI, 0.30-0.71 for oral cavity; OR, 0.58; 95% CI, 0.41-0.82 for oropharynx/hypopharynx; and OR, 0.61; 95% CI, 0.37-1.01 for oral cavity/pharynx not otherwise specified) and across strata of selected covariates.

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  • (PMID = 20570908.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50CA90388; United States / NIDA NIH HHS / DA / R01 DA011386; United States / NCI NIH HHS / CA / R03 CA113157-02; United States / NCI NIH HHS / CA / R01 CA078609; United States / NIEHS NIH HHS / ES / R21ES011667; United States / NCI NIH HHS / CA / T32 CA009142; United States / NCI NIH HHS / CA / U01 CA096134; United States / Intramural NIH HHS / / ; United States / NCI NIH HHS / CA / R03CA113157; United States / NCI NIH HHS / CA / R01CA51845; United States / NCI NIH HHS / CA / CA100679; United States / NCI NIH HHS / CA / U01CA96134; United States / NCI NIH HHS / CA / R03 CA077954; United States / NIEHS NIH HHS / ES / R21 ES011667; United States / NCI NIH HHS / CA / R03 CA113157-01; United States / NCI NIH HHS / CA / R01 CA100679; United States / NCI NIH HHS / CA / R03 CA113157; United States / NCI NIH HHS / CA / R03CA77954; United States / NIDA NIH HHS / DA / R01DA11386; United States / NCI NIH HHS / CA / T32CA09142; United States / NCI NIH HHS / CA / CA78609; United States / NCI NIH HHS / CA / P50 CA090388
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coffee; 0 / Tea; 3G6A5W338E / Caffeine
  • [Other-IDs] NLM/ NIHMS206689; NLM/ PMC3047460
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77. Kubota A, Furukawa M, Fujita Y, Yagi H: [Concurrent chemoradiotherapy for resectable locoregionally advanced squamous cell carcinoma of the head and neck-analysis of factors associated with toxicity and efficacy]. Nihon Jibiinkoka Gakkai Kaiho; 2010 Mar;113(3):101-9
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  • PFS significantly differed between 72% in T0 to 2 and 49% in T3 to 4, 77% in CR and 53% in PR, and 22% in the tongue and 58% in the hypopharynx, 66% in the oropharynx, and 53% in the larynx.
  • Other additional treatment will be needed, however, to improve OS and PFS in cases having a dismal diagnosis such as tongue cancer.


78. Vartanian JG, Carvalho AL, Toyota J, Kowalski IS, Kowalski LP: Socioeconomic effects of and risk factors for disability in long-term survivors of head and neck cancer. Arch Otolaryngol Head Neck Surg; 2006 Jan;132(1):32-5
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  • PATIENTS: Eligible patients had squamous cell carcinoma of the upper aerodigestive tract, were employed or had an active professional career at the time of initial diagnosis, and were disease free for at least 2 years at the time of interview.
  • The tumor sites were the oral cavity in 158 (52.5%), oropharynx in 55 (18.3%), larynx in 78 (25.9%), and hypopharynx in 10 (3.3%).

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  • (PMID = 16415426.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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79. Distel LV, Fickenscher R, Dietel K, Hung A, Iro H, Zenk J, Nkenke E, Büttner M, Niedobitek G, Grabenbauer GG: Tumour infiltrating lymphocytes in squamous cell carcinoma of the oro- and hypopharynx: prognostic impact may depend on type of treatment and stage of disease. Oral Oncol; 2009 Oct;45(10):e167-74
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  • [Title] Tumour infiltrating lymphocytes in squamous cell carcinoma of the oro- and hypopharynx: prognostic impact may depend on type of treatment and stage of disease.
  • he purpose of this study was to evaluate the prognostic influence of various subtypes of tumour infiltrating lymphocytes (TIL) in head and neck cancer, in particular the potential influence of regulatory T cells (Treg) in relation to different treatment modalities was addressed.
  • A total of 115 patients with squamous cell carcinoma of the oro- and hypopharynx were selected.
  • [MeSH-major] Carcinoma, Squamous Cell / immunology. Hypopharyngeal Neoplasms / immunology. Lymphocytes, Tumor-Infiltrating / immunology. Oropharyngeal Neoplasms / immunology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. T-Lymphocytes, Regulatory / immunology

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  • (PMID = 19576838.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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80. Mussak EN, Tu JJ, Voigt EP: Malignant solitary fibrous tumor of the hypopharynx with dysphagia. Otolaryngol Head Neck Surg; 2005 Nov;133(5):805-7
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  • [Title] Malignant solitary fibrous tumor of the hypopharynx with dysphagia.
  • [MeSH-major] Hypopharynx / pathology. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / surgery. Neoplasms, Fibrous Tissue / diagnosis. Neoplasms, Fibrous Tissue / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Laryngectomy / methods. Laryngoscopy / methods. Magnetic Resonance Imaging / methods. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 16274816.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Cavalot AL, Schindler A, Juliani E, Schindler O, Cortesina G: Playing a brass instrument after total laryngectomy: a case report. Head Neck; 2009 Aug;31(8):1102-6
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  • Videofluorography revealed an enlarged hypopharynx, a thick neoglottis while playing at lower tone; at higher pitch the tongue base was retracted, the neoglottis was thin and stretched, and the subneoglottic area was extremely enlarged.

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  • [Copyright] Copyright 2009 Wiley Periodicals, Inc.
  • (PMID = 19189337.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Guha G, Gupta S, Chakraborty S: Pharyngo oesophageal strictures and its reconstruction by delto pectoral flaps. Indian J Otolaryngol Head Neck Surg; 2005 Jul;57(3):229-34
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  • Oesophageal reconstruction by viscera like stomach or colon often produces anastomic stricture at the upper anastomic site with hypopharynx or upper oesophagus.

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  • [Cites] Br J Plast Surg. 1971 Apr;24(2):174-83 [4932091.001]
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  • (PMID = 23120178.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451337
  • [Keywords] NOTNLM ; DP-deltopectoral flap / circumferential stricture / hypopharynx / oesophagus / partial stricture / post-anastomotic structure / primary corrosive stricture
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83. Doweck I, Robbins KT, Samant S, Vieira F: Intra-arterial chemoradiation for T3-4 oral cavity cancer: treatment outcomes in comparison to oropharyngeal and hypopharyngeal carcinoma. World J Surg Oncol; 2008;6:2
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  • [Title] Intra-arterial chemoradiation for T3-4 oral cavity cancer: treatment outcomes in comparison to oropharyngeal and hypopharyngeal carcinoma.
  • PATIENTS AND METHODS: From a series of 240 patients with stage III-IV carcinoma of the upper aerodigestive tract who were treated consecutively according to the RADPLAT protocol, a subset analysis of 155 patients with T3-T4 SCC (Oral cavity SCC N = 22, oropharynx SCC N = 94 and hypopharynx SCC N = 39), was performed.
  • In comparison, local disease control for the oropharynx and hypopharynx groups was 86% and 79% respectively.
  • The overall survival rate for the oropharyngeal and hypopharyngeal groups were 41% and 6% respectively CONCLUSION: Patients with locally advanced oral cavity cancer treated with the chemoradiation protocol RADPLAT have outcomes that are equal or better compared to patients with similar disease involving the oropharynx and hypopharynx.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / therapy. Mouth Neoplasms / pathology. Mouth Neoplasms / therapy. Oropharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cisplatin / administration & dosage. Cohort Studies. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Infusions, Intra-Arterial. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome


84. Eyibilen A, Baykara M, Ozbay AS: [A possible cause of snoring: bilateral tortuosity of the internal carotid artery]. Kulak Burun Bogaz Ihtis Derg; 2008 Jul-Aug;18(4):250-2
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  • On physical examination, there was bulging and bilateral pulsation in the oropharyngeal wall, narrowing the passage and extending to the hypopharynx.

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  • (PMID = 19052495.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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85. Hall SF, Groome PA, Irish J, O'Sullivan B: Towards further understanding of prognostic factors for head and neck cancer patients: the example of hypopharyngeal cancer. Laryngoscope; 2009 Apr;119(4):696-702
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  • [Title] Towards further understanding of prognostic factors for head and neck cancer patients: the example of hypopharyngeal cancer.
  • METHODS: Retrospective population-based study of patients with cancer of the hypopharynx in Ontario, Canada, from January 1990 to December 1999 identifying and comparing prognostic factors for different survival outcomes and different subpopulations using Kaplan Meier analysis and Cox Proportional Hazards models.
  • CONCLUSIONS: N and T category were the dominant prognostic factors in hypopharyngeal cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Hypopharyngeal Neoplasms / classification. Hypopharyngeal Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Alcoholism / epidemiology. Biopsy. Cause of Death. Comorbidity. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 19205009.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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86. Kim KH, Kim MC, Jung GJ: Gastric cancer occurring in a patient with Plummer-Vinson syndrome: a case report. World J Gastroenterol; 2005 Nov 28;11(44):7048-50
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  • Plummer-Vinson syndrome (sideropenic dysphagia) is characterized by dysphagia due to an upper esophageal or hypopharyngeal web in patients with chronic iron deficiency anemia.
  • This syndrome is thought to be precancerous because squamous cell carcinoma of hypopharynx, oral cavity or esophagus takes place in 10% of those patients suffering from this malady, but it is even more unusual that Plummer-Vinson syndrome should be accompanied by gastric cancer.

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  • (PMID = 16437616.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4717054
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87. Mesía R, Majem M, Barretina Ginesta MP, Galiana R, Mañós M, Guedea F, Montes A, Monner A, Pérez J, Cardenal F: Treatment of patients with unresectable squamous head and neck cancer with induction chemotherapy followed by hyperfractionated radiotherapy. Cancer Radiother; 2008 Mar;12(2):88-95
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  • Tumor resectability and response was assessed by a multidisciplinary committee.
  • Tumor location: 62 oropharynx, 22 hypopharynx, eight oral cavity and seven larynx.
  • Tumor response at the end of treatment: 61 patients complete response, 17 partial response, two stable disease, 10 progressive disease and nine unevaluated.

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  • (PMID = 18155633.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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88. El-Deiry M, Funk GF, Nalwa S, Karnell LH, Smith RB, Buatti JM, Hoffman HT, Clamon GH, Graham SM, Trask DK, Dornfeld KJ, Yao M: Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer. Arch Otolaryngol Head Neck Surg; 2005 Oct;131(10):879-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS: Patients with stage III or IV squamous cell carcinoma of the oropharynx, hypopharynx, and larynx who underwent SRT or received CRT.
  • [MeSH-minor] Combined Modality Therapy. Female. Health Status Indicators. Humans. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy. Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / drug therapy. Laryngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / surgery. Male. Middle Aged. Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy. Oropharyngeal Neoplasms / surgery. Speech, Alaryngeal

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  • (PMID = 16230590.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01CA106908-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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89. Saito K, Inagaki K, Naganishi H, Takaoka T, Isogai Y, Ogawa K: [Electrocautery snare efficacy in head and neck lesion treatment]. Nihon Jibiinkoka Gakkai Kaiho; 2009 Nov;112(11):739-46
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  • Lesions were localized in the larynx, oropharynx, hypopharynx, or tracheostoma.

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  • (PMID = 19999151.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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90. Abrigo JM, King AD, Leung SF, Vlantis AC, Wong JK, Tong MC, Tse GM, Ahuja AT: MRI of radiation-induced tumors of the head and neck in post-radiation nasopharyngeal carcinoma. Eur Radiol; 2009 May;19(5):1197-205
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  • RITs arose in the maxillary region (9), oro/hypopharynx and oral cavity (5), external auditory canal (4), nasopharynx and sphenoid sinus (2) and brain (1).


91. Sun ZY, Zhang ZP, Huhe M: [Giant fibrovascular polyp of hypopharynx - a case report]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Feb;45(2):161-2
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  • [Title] [Giant fibrovascular polyp of hypopharynx - a case report].
  • [MeSH-major] Angiofibroma / diagnosis. Diagnostic Errors. Pharyngeal Neoplasms / diagnosis. Polyps / diagnosis

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  • (PMID = 20398520.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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92. Wang CP, Lee YC, Lou PJ, Yang TL, Chen TC, Huang CC, Ko JY: Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer. Oral Oncol; 2009 Jul;45(7):615-20
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  • Except three patients with very narrow space or the presence of the tumor in the neopharynx, transnasal EGD could completely evaluate the upper digestive tract in 33 patients and found one patient with local recurrent hypopharyngeal cancer, seven patients with newly diagnosed hypopharyngeal cancer, four patients with esophageal cancer, and one patient with simultaneous hypopharyngeal and esophageal cancers, which were all successfully biopsied and proven microscopically.
  • One patient had a benign tumor on the epiglottis and the other NPC patient had extensive soft tissue necrosis in the pyriform sinus as a cause of dysphagia.
  • The present study indicates that unsedated transnasal EGD is feasible to confidently distinguish between functionally/anatomically-related dysphagia and newly growing tumors in the upper digestive tract, and to obtain biopsy specimens for pathological diagnosis from the tumors in a single session.
  • [MeSH-major] Deglutition Disorders / diagnosis. Endoscopy, Digestive System / methods. Esophageal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 19027351.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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93. Li XD, Gao XM, Zeng XL: [A magnetic resonance imaging research of upper airway and surrounding tissues of 83 non-snoring males]. Beijing Da Xue Xue Bao; 2005 Apr 18;37(2):190-4
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  • The dimensions and cross-section area of nasopharynx, velopharynx, glossopharynx, hypopharynx and whole upper airway with its surrounding tissues were measured with MRI intrinsic software.
  • With increase in age, some nasopharynx items showed increase tendency, while little change showed in velopharynx, glossopharynx and hypopharynx.

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  • (PMID = 15841153.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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94. Altrabulsi B, Carrizo F, Luna MA: Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases. Ann Diagn Pathol; 2006 Jun;10(3):149-53
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  • Two tumors were located in the hypopharynx and one was located in the nasal cavity.
  • Histologically, they were composed of conventional basaloid squamous carcinomas with extensive malignant spindle cell proliferation, comprising more than 50% of the tumor.
  • The patients were alive 14 (case patient 1), 10 (case patient 2), and 8 (case patient 3) months after diagnosis.
  • In the absence of evidence from immunohistochemical or electron microscopy studies, a polypoid malignant spindle cell tumor of a mucosal surface of the upper aerodigestive tract should be considered a sarcomatoid carcinoma until proven otherwise.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology. Hypopharynx / pathology. Maxillary Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Laryngectomy. Male. Maxilla / surgery. Middle Aged. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16730309.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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95. Ebert EC: Review article: the gastrointestinal complications of myositis. Aliment Pharmacol Ther; 2010 Feb 1;31(3):359-65
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  • There is tongue weakness, flaccid vocal cords, poor palatal motion and pooling of secretions in the distended hypopharynx.

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  • (PMID = 19886949.001).
  • [ISSN] 1365-2036
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 73
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96. Virós Porcuna D, León Vintró X, López Vilas M, Pujol Olmo A, Masià Ayala J, Quer Agustí M: [Pectoralis major flaps. Evolution of their use in the age of microvascularized flaps]. Acta Otorrinolaringol Esp; 2008 Jun-Jul;59(6):263-8
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  • [Transliterated title] Colgajo de pectoral mayor: evolución de su uso en la era de los colgajos microanastomosados.
  • RESULTS: 34 % of the revised flaps were used for reconstruction of the hypopharynx, 33 % for the oropharynx, 21 % for soft tissues, and 12 % for the repair of pharyngocutaneous fistulae.
  • CONCLUSIONS: In this age of microvascularized flaps, we believe that PMMF still has a privileged role in the repair of hypopharynx and cervical lesions.

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  • (PMID = 18588785.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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97. Sakai A, Okami K, Ebisumoto K, Sugimoto R, Maki D, Iida M: New techniques to detect unknown primaries in cervical lymph node metastasis. Laryngoscope; 2010 Sep;120(9):1779-83
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  • All primary lesions identified using the new method were located in the hypopharynx.
  • The higher rate achieved with the new method was probably due to the clear visualization of the hypopharynx.
  • [MeSH-major] Endoscopes. Lymphatic Metastasis / pathology. Neoplasms, Unknown Primary / diagnosis. Otorhinolaryngologic Neoplasms / diagnosis. Video Recording / instrumentation
  • [MeSH-minor] Equipment Design. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / pathology. Humans. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / pathology. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / pathology. Oropharyngeal Neoplasms / diagnosis. Oropharyngeal Neoplasms / pathology. Retrospective Studies. Sensitivity and Specificity. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology

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  • (PMID = 20717942.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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98. Wang GP, Jin DJ, Xiao H: [Cervical lymph node metastasis of malignant fibrous histiocytoma of the hypopharynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Oct;41(10):792-3
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  • [Title] [Cervical lymph node metastasis of malignant fibrous histiocytoma of the hypopharynx].

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  • (PMID = 17190436.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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99. Becker M, Burkhardt K, Dulguerov P, Allal A: Imaging of the larynx and hypopharynx. Eur J Radiol; 2008 Jun;66(3):460-79
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  • [Title] Imaging of the larynx and hypopharynx.
  • The purpose of this article is to review currently used imaging protocols for the evaluation of pathologic conditions of the larynx and hypopharynx, to describe key anatomic structures in the larynx and hypopharynx that are relevant to tumor spread and to discuss the clinical role of Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and PET CT in the pretherapeutic workup and posttherapeutic follow-up of patients with squamous cell carcinoma of this region.
  • A detailed discussion of the characteristic neoplastic submucosal invasion patterns, including extension to the preepiglottic space, paraglottic space and laryngeal cartilages and the implications of imaging for tumor staging and treatment planning is provided.
  • As the majority of non-neoplastic conditions do not require imaging the role of CT and MRI is discussed in some particular situations, such as to delineate cysts and laryngoceles, abscess formation in inflammatory conditions, to evaluate laryngeal and hypopharyngeal involvement in granulomatous and autoimmune diseases, and to evaluate the extent of laryngeal fractures due to severe blunt trauma.
  • [MeSH-major] Diagnostic Imaging. Laryngeal Diseases / diagnosis. Pharyngeal Diseases / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / diagnosis. Hypopharynx / anatomy & histology. Hypopharynx / injuries. Hypopharynx / pathology. Larynx / anatomy & histology. Larynx / injuries. Larynx / pathology. Lymphatic Metastasis / diagnosis. Magnetic Resonance Imaging / methods. Neoplasm Invasiveness / diagnosis. Neoplasm Metastasis / diagnosis. Neoplasm Staging. Tomography, Emission-Computed / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 18495402.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 43
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100. Richmon JD, Brumund KT: Reconstruction of the hypopharynx: current trends. Curr Opin Otolaryngol Head Neck Surg; 2007 Aug;15(4):208-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of the hypopharynx: current trends.
  • PURPOSE OF REVIEW: Reconstruction of the hypopharynx continues to present a clinical challenge for the reconstructive surgeon.
  • Increased availability of surgeons trained in microvascular reconstruction and the continued high published success rates have made free flaps an attractive option for hypopharyngeal reconstruction.
  • SUMMARY: With continued publication of overall high success rates coupled with superior functional outcome and increased availability of surgeons trained in microvascular reconstruction, fasciocutaneous free flap reconstruction of the hypopharynx will probably surpass intestinal flaps in reliability and popularity.
  • [MeSH-major] Hypopharynx / surgery. Reconstructive Surgical Procedures / methods

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  • (PMID = 17620892.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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