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1. Nazarko L: 'Nurses must lead the discussion on HCA roles'. Nurs Times; 2008 Apr 8-14;104(14):10
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  • [Title] 'Nurses must lead the discussion on HCA roles'.

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  • (PMID = 18497231.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Pereira FM, Bueno MI: Image evaluation with chemometric strategies for quality control of paints. Anal Chim Acta; 2007 Apr 11;588(2):184-91
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  • The images were converted in gray color scale histograms, the resulting data were organized into a matrix form and analyzed with the help of principal component analysis (PCA) and hierarchical cluster analysis (HCA).

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  • (PMID = 17386809.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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3. Zhao LH, Wu MH, Xiang BR: Analysis of Psoralea corylifolia L. fruits in different regions. Chem Pharm Bull (Tokyo); 2005 Aug;53(8):1054-7
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  • [Title] Analysis of Psoralea corylifolia L. fruits in different regions.
  • Application of multivariate data analysis has become a popular method in the last decades, mainly because it can provide information not otherwise accessible.
  • The information includes classification, searching similarities, finding relationships, finding physical significance to principal components, etc.
  • The results were studied by hierarchical cluster analysis (HCA) and principal components analysis (PCA).
  • [MeSH-minor] Chromatography, High Pressure Liquid. Cluster Analysis. Multivariate Analysis

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  • (PMID = 16079549.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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4. Skalický T, Treska V, Sutnar A, Liska V, Molácek J, Mírka H, Ferda J, Ohlídalová K, Slauf F, Novák M: [Surgical treatment of benign liver tumours--indications and results]. Zentralbl Chir; 2009 Apr;134(2):141-4
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  • [Title] [Surgical treatment of benign liver tumours--indications and results].
  • [Transliterated title] Wann sollte man benigne Lebertumoren chirurgisch behandeln?*
  • The authors present their results on the treatment of benign liver tumors.
  • Benign liver lesions were rather rare compared to malignant tumours, for which 273 patients were treated within the same period.
  • The most often found benign -lesions were hepatocellular adenoma, focal nodular hyperplasia (FNH) and hemangioma.
  • Sometimes, it was not possible to make a correct diagnosis preoperatively.
  • The surgical procedures used for benign tumours were mostly enucleation and non-anatomic parenchyma-saving resection (55.4 %).
  • [MeSH-major] Adenoma, Liver Cell / surgery. Focal Nodular Hyperplasia / surgery. Hemangioma / surgery. Hepatectomy / methods. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cystadenoma / diagnosis. Cystadenoma / surgery. Diagnosis, Differential. Diagnostic Imaging. Female. Hamartoma / diagnosis. Hamartoma / surgery. Humans. Lymphangioma / diagnosis. Lymphangioma / surgery. Male. Middle Aged. Young Adult

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  • (PMID = 19382044.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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5. Catasus L, D'Angelo E, Pons C, Espinosa I, Prat J: Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations. Mod Pathol; 2010 May;23(5):694-702
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  • Expression profiling of 22 genes involved in PI3K-AKT signaling pathway was analyzed in 38 endometrial carcinomas using TaqMan low-density array (TLDA) analysis.
  • The gene expression pattern was analyzed by hierarchical clustering analysis.
  • Unsupervised clustering divided the high-grade endometrial carcinomas into two clusters.
  • Almost all non-endometrioid adenocarcinomas (serous and clear cell adenocarcinomas) were segregated into this cluster.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cluster Analysis. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Signal Transduction / genetics. Tissue Array Analysis. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20173732.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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6. Delmo Walter EM, Hübler M, Alexi-Meskishvili V, Miera O, Weng Y, Loforte A, Berger F, Hetzer R: Staged surgical palliation in hypoplastic left heart syndrome and its variants. J Card Surg; 2009 Jul-Aug;24(4):383-91
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  • [Title] Staged surgical palliation in hypoplastic left heart syndrome and its variants.
  • BACKGROUND: Surgical options for infants with hypoplastic left heart syndrome (HLHS) and/or its variants are cardiac transplantation or the heart-preserving staged palliation with Norwood operation,followed by a two-staged Fontan procedure.
  • The causes of mortality were sepsis, capillary leak,or heart failure.
  • One patient underwent heart transplantation after the second stage because of heart failure.
  • Among 34 Norwood survivors, four are slightly tachypneic from a mild pulmonary hyperperfusion; one presents symptoms of minimal brain disease.
  • Lower operative weight, ascending aortic size, prolonged duration of cardiopulmonary bypass, and hypothermic circulatory arrest were identified to significantly influence early mortality after the Norwood procedure.
  • [MeSH-major] Cardiovascular Surgical Procedures / methods. Hypoplastic Left Heart Syndrome / mortality. Hypoplastic Left Heart Syndrome / surgery. Outcome Assessment (Health Care). Palliative Care
  • [MeSH-minor] Abnormalities, Multiple. Aorta / pathology. Arrhythmias, Cardiac / mortality. Body Weight. Cardiopulmonary Bypass / statistics & numerical data. Circulatory Arrest, Deep Hypothermia Induced. Female. Follow-Up Studies. Heart Failure / mortality. Humans. Infant. Infant, Newborn. Male. Multivariate Analysis. Retrospective Studies. Risk Factors. Sepsis / mortality. Time Factors

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  • (PMID = 19040407.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Wang D, Lagerstrom R, Sun C, Bishof L, Valotton P, Götte M: HCA-vision: Automated neurite outgrowth analysis. J Biomol Screen; 2010 Oct;15(9):1165-70
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  • [Title] HCA-vision: Automated neurite outgrowth analysis.
  • Automating the analysis of neurons in culture represents a key aspect of the search for neuroactive compounds.
  • A number of commercial neurite analysis software packages tend to measure some basic features such as total neurite length and number of branching points.
  • The authors have developed a suite of image analysis tools that will allow researchers to produce quality analyses at primary screening rates.
  • In mixed cell populations, neurons can be filtered and separated from other brain cell types so that neurite analysis can be performed only on neurons.
  • It supports batch processing with a built-in database to store the batch-processing results, a batch result viewer, and an ad hoc query builder for users to retrieve features of interest.
  • The suite of tools has been deployed into a software package called HCA-Vision.
  • The free version of the software package is available at http://www.hca-vision.com.

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  • (PMID = 20855562.001).
  • [ISSN] 1552-454X
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
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8. Holst RM, Laurini R, Jacobsson B, Samuelsson E, Sävman K, Doverhag C, Wennerholm UB, Hagberg H: Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med; 2007 Dec;20(12):885-93
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  • OBJECTIVE: To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM).
  • STUDY DESIGN: Cervical and amniotic fluid interleukin (IL)-6, IL-8, IL-18, monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 from pregnant women (at <or=34 weeks of gestation) in PTL (N = 42) were analyzed and related to the subsequent occurrence of HCA or inflammatory signs in the placenta.
  • RESULTS: Intra-amniotic levels of IL-6, IL-8, IL-18, MCP-1, and MCP-3 were significantly higher in PTL cases with HCA compared to non-HCA controls, whereas no such relationship was obtained in the PPROM group.
  • Cervical IL-8 and IL-6 (but not IL-18, MCP-1, MCP-2, and MCP-3) in PTL patients was associated with HCA, and at a cut-off level of 10.0 ng/mL cervical IL-8 was a strong predictor of HCA in the PTL cases (sensitivity 100%, specificity 67%, positive predictive value 63%, negative predictive value 100%).
  • The cytokine and chemokine levels in the group with inflammatory signs were generally higher than in controls but lower compared to the concentrations in the HCA group.
  • CONCLUSIONS: The amniotic levels of IL-6, IL-8, IL-18, and the CC-chemokines MCP-1 and MCP-3 in PTL patients all predicted HCA, whereas only IL-8 was a clinically useful marker of HCA in the cervical fluid.

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  • (PMID = 18050018.001).
  • [ISSN] 1476-7058
  • [Journal-full-title] The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [ISO-abbreviation] J. Matern. Fetal. Neonatal. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chemokine CCL2; 0 / Chemokines; 0 / Cytokines; 0 / Interleukins
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9. Hancock H, Campbell S, Ramprogus V, Kilgour J: Role development in health care assistants: the impact of education on practice. J Eval Clin Pract; 2005 Oct;11(5):489-98
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  • In nursing this has resulted in the delegation of 'nursing care' to health care assistants (HCAs).
  • This study sought to evaluate the impact of a HCA Development Programme on care delivery.
  • Secondly, it sought to understand the preparedness of HCAs to undertake the programme and the new roles set for them.
  • Semi-structured interviews were conducted with four HCAs, eight of each of their colleagues and four patients.
  • For part two, 12 HCAs were interviewed.
  • Data were analysed following the principles of thematic analysis.
  • FINDINGS: The findings for part one showed positive changes to the HCAs' role, which included skill and knowledge development, increased confidence and initiative and a more holistic approach to care.
  • The HCAs in part two voiced positive and negative views of their role development.
  • Of the 12 HCAs interviewed, eight were prepared to attend the programme, two were undecided, and two were reluctant to attend.
  • CONCLUSIONS: The findings indicated that while the HCA Development Programme positively influenced the role of the HCA, there was a need to invest more into preparation for the restructuring of roles.

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  • (PMID = 16164591.001).
  • [ISSN] 1356-1294
  • [Journal-full-title] Journal of evaluation in clinical practice
  • [ISO-abbreviation] J Eval Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Henriksen U, Fog J, Loechel F, Praestegaard M: Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays. Comb Chem High Throughput Screen; 2008 Aug;11(7):537-44
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  • [Title] Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays.
  • Multiplexing of GFP based and immunofluorescence translocation assays enables easy acquisition of multiple readouts from the same cell in a single assay run.
  • Immunofluorescence assays monitor translocation, phosphorylation, and up/down regulation of endogenous proteins.
  • GFP-based assays monitor translocation of stably expressed GFP-fusion proteins.
  • Such assays may be multiplexed along (vertical), across (horizontal), and between (branch) signal pathways.
  • 1) The MK2-GFP assay monitors translocation of MK2-GFP from the nucleus to the cytoplasm in response to stimulation of the p38 pathway.
  • By applying different immunofluorescent assays to the MK2 assay, a multiplexed HCA system is created for deconvolution of p38 pathway activation including assay readouts for MK2, p38, NFkappaB, and c-Jun.
  • 2) A method for evaluating GPCR activation and internalization in a single assay run has been established by multiplexing GFP-based internalization assays with immunofluorescence assays for downstream transducers of GPCR activity: pCREB (cAMP sensor), NFATc1 (Ca(2+) sensor), and ERK (G-protein activation).
  • 3) Cell toxicity readouts can be linked to primary readouts of interest via acquisition of secondary parameters describing cellular morphology.
  • The ATF6 Redistribution assay is provided as an example.
  • These multiplex strategies provide a unique opportunity to enhance HCA data quality and save time during drug discovery.
  • From a single assay run, several assay readouts are obtained that help the user to deconvolute the mode of action of test compounds.
  • [MeSH-major] Antibodies / analysis. Green Fluorescent Proteins / analysis. Signal Transduction

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  • (PMID = 18694390.001).
  • [ISSN] 1386-2073
  • [Journal-full-title] Combinatorial chemistry & high throughput screening
  • [ISO-abbreviation] Comb. Chem. High Throughput Screen.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.- / Phosphotransferases
  • [Number-of-references] 23
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11. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CAS No. 123-35-3) in F344/N rats and B6C3F1 mice (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Dec;(557):1-163
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  • Except for lesion incidence data in groups administered 2 g/kg or less, data from rats that died early were excluded from the analysis and summary tables.
  • Right kidney and liver weights of dosed males and females were generally significantly greater than those of the vehicle controls.
  • The right kidney weights of 1 g/kg females and the liver weights of females administered 0.5 or 1 g/kg were significantly increased.
  • In the standard evaluation of the kidney, the incidence of renal tubule adenoma was significantly increased in 0.5 g/kg male rats, and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in 0.25 and 0.5 g/kg males.
  • In both the extended evaluation and the combined standard and extended evaluations, the incidences of renal tubule adenoma and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in the 0.25 and 0.5 g/kg groups of males.
  • The incidences of liver neoplasms were significantly increased in 0.25 and/or 0.5 g/kg males and 0.25 g/kg females.
  • Liver neoplasms included hepatocellular adenoma and hepatocellular carcinoma in males and females and hepatoblastoma in males.
  • The incidences of hepatocellular hypertrophy were significantly increased in 0.5 g/kg males and females, as was the incidence of mixed cell focus in 0.5 g/kg females.
  • GENETIC TOXICOLOGY: beta-myrcene did not show evidence of genotoxicity in assays conducted by the NTP.
  • No mutagenicity was observed in any of several strains of Salmonella typhimurium or Escherichia coli in two independent Ames assays conducted with and without exogenous metabolic activation.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female F344/N rats based on increased incidences of renal tubule adenoma.
  • There was clear evidence of carcinogenic activity of beta-myrcene in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma and carcinoma.
  • Administration of beta-myrcene induced nonneoplastic lesions in the kidney of male and female rats, nose of male rats, and liver of male and female mice.
  • [MeSH-major] Adenoma / chemically induced. Carcinoma, Hepatocellular / chemically induced. Hepatoblastoma / chemically induced. Kidney Neoplasms / chemically induced. Liver Neoplasms / chemically induced. Monoterpenes / toxicity. Neoplasms, Experimental / chemically induced

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  • (PMID = 21415873.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Monoterpenes; 123-35-3 / beta-myrcene
  • [Investigator] Chan PC; Cesta MF; Sills RC; Bishop JB; Bristol DW; Bucher JR; Chhabra RS; Foster PM; Herbert RA; Hooth MJ; King-Herbert AP; Kissling GE; Malarkey DE; Roycroft JH; Sanders JM; Smith CS; Travlos GS; Walker NJ; Witt KL
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12. Lee KH, Lee BM: Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A; 2007 Mar 1;70(5):388-92
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  • [Title] Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia.
  • (-)-Hydroxycitric acid (HCA) is widely used as an ingredient for nutritional supplements aimed at reducing food intake, appetite, and body weight.
  • In this study, the genotoxicity of HCA was evaluated using three tests: a bacterial reverse mutation assay (Ames test), an in vitro chromosomal aberration (CA) test, and an in vivo micronucleus (MN) test.
  • HCA was negative by the Ames test in the presence or absence of a microsomal metabolizing system.
  • HCA did not induce mutagenic activity in the Ames test, and no significant mutagenic potency was indicated by CA tests.
  • However, HCA significantly and dose-dependently increased the number of MNPCEs (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) and PCE/(PCE + NCE) ratios according to the MN test.
  • These results suggest that HCA preferentially induce micronuclei.
  • [MeSH-minor] Animals. Cell Line. Chromosome Aberrations / chemically induced. Cricetinae. Cricetulus. Garcinia cambogia. Mice. Mutagenicity Tests

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  • [CommentIn] J Toxicol Environ Health A. 2008;71(5):348-9; author reply 350-1 [18214809.001]
  • (PMID = 17454564.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Citrates; 8W94T9026R / hydroxycitric acid
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13. Lim SH, Feng L, Kemling JW, Musto CJ, Suslick KS: An optoelectronic nose for the detection of toxic gases. Nat Chem; 2009 Oct;1(7):562-7
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  • The sensor consists of a disposable array of cross-responsive nanoporous pigments with colours that are changed by diverse chemical interactions with analytes.
  • Different TICs were identified readily using a standard chemometric approach (hierarchical clustering analysis), with no misclassifications over 140 trials.

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  • (PMID = 20160982.001).
  • [ISSN] 1755-4349
  • [Journal-full-title] Nature chemistry
  • [ISO-abbreviation] Nat Chem
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES016011-03; United States / NIEHS NIH HHS / ES / U01 ES016011; United States / NIEHS NIH HHS / ES / U01 ES016011-03; United States / NIEHS NIH HHS / ES / U01ES016011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gases
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14. Kacerovský M, Drahosová M, Hornychová H, Plísková L, Bolehovská R, Förstl M, Tosner J, Lesko D, Andrýs C: [Amniotic fluid interleukin 6 levels in preterm premature rupture of membranes]. Ceska Gynekol; 2009 Dec;74(6):403-10
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  • OBJECTIVE: The purpose of this study was to determinate the changes of amniotic fluid interleukin 6 (IL-6) concentrations in patients with preterm premature rupture of the membranes (PPROM), and in the presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA).
  • The aim was to examine amniotic fluid IL-6 in relation to MIAC and HCA.
  • Twenty-eight of 37 patients placentas were collected and assessed for presence or absence HCA.
  • RESULTS: There was significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without MIAC and HCA (patients with MIAC and HCA: median 915 pg/ml, range 651-1854 pg/ml vs. patients without MIAC and HCA: median 780 pg/ml, range 184-1059 pg/ml; p=0.047).
  • There was no significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without HCA (patients with HCA: median 829 pg/ml, range 195-1992 pg/ml vs. patients without HCA: median 768 pg/ml, range 184-1890 pg/ml; p = 0.31).
  • CONCLUSION: Amniotic fluid IL-6 concentrations patients with PPROM with presence HCA and MIAC were significantly higher than IL-6 concentration patients without HCA and MIAC.

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  • (PMID = 21246786.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Interleukin-6
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15. Renaud S, Hays AP, Brannagan TH 3rd, Sander HW, Edgar M, Weimer LH, Olarte MR, Dalakas MC, Xiang Z, Danon MJ, Latov N: Gene expression profiling in chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol; 2005 Feb;159(1-2):203-14
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  • Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups.
  • Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.
  • [MeSH-minor] Adult. Aged. Chronic Disease. Female. Humans. Male. Middle Aged. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / genetics. Sural Nerve / pathology. Up-Regulation


16. Silva AR, Fragoso AC, Oliveira M, Costa-Maia J, Estevão-Costa, Bessa-Monteiro A, Campos M: [Laparoscopic excision of a hepatic mesothelial cyst]. Cir Pediatr; 2009 Oct;22(4):229-32
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  • [Title] [Laparoscopic excision of a hepatic mesothelial cyst].
  • [Transliterated title] Escisión laparoscópica de quiste mesotelial hepático.
  • Over the past few years there has been an increase in application of minimally invasive techniques in pediatric surgery, especially in the approach of liver lesions.
  • The authors present the clinical case of a three year old child, referred to our institution after an incidental finding of a liver cystic lesion in abdominal ultrasound.
  • The MRI confirmed the presence of the cystic lesion and pointed, as a possible etiology, a cystic cyst adenoma of the liver.
  • The anatomo-pathological and immunohistochemical studies concluded it was a mesotelial cyst of the liver.
  • The mesothelial cysts of the liver are very rare lesions, with difficult preoperative diagnosis.
  • [MeSH-major] Cysts / surgery. Hepatectomy / methods. Laparoscopy. Liver Diseases / surgery

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  • (PMID = 20405662.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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17. Puangsombat K, Smith JS: Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. J Food Sci; 2010 Mar;75(2):T40-7
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  • Heterocyclic amines (HCAs) are mutagenic compounds formed during cooking muscle foods at high temperature.
  • Inhibition of HCAs by rosemary extracts were evaluated with beef patties cooked at 191 degrees C (375 degrees F) for 6 min each side and 204 degrees C (400 degrees F) for 5 min each side.
  • The 5 extracts were directly added to beef patties at 3 levels (0.05%, 0.2%, and 0.5%) before cooking and HCA contents were extracted and quantified.
  • There was no statistical difference in the inhibition of HCAs in the 0.05%, 0.2%, and 0.5% rosemary extracts.
  • When cooking at 204 degrees C (400 degrees F) for 5 min each side, rosemary extracts 10E and 20E were superior to rosemary extracts 100W, 30E, and 40E in inhibiting HCA formation.
  • The inhibiting effect of rosemary extracts on HCA formation corresponded to their antioxidant activity based on a DPPH scavenging assay.
  • It is possible that these compounds might act synergistically in inhibiting the formation of HCAs.
  • [MeSH-major] Antioxidants / pharmacology. Heterocyclic Compounds, 2-Ring / analysis. Meat Products / analysis. Plant Extracts / pharmacology. Rosmarinus
  • [MeSH-minor] Animals. Cattle. Cooking / methods. Ethanol. Food Analysis / methods. Food Handling / methods. Gas Chromatography-Mass Spectrometry / methods. Imidazoles / analysis. Quinoxalines / analysis. Solid Phase Microextraction / methods. Time Factors. Water

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  • (PMID = 20492265.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Heterocyclic Compounds, 2-Ring; 0 / Imidazoles; 0 / Plant Extracts; 0 / Quinoxalines; 059QF0KO0R / Water; 3K9958V90M / Ethanol; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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18. Silva JP, Fonseca Ld, Baumgratz JF, Castro RM, Franchi SM, Lianza AC, Vila JH: Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach. Rev Bras Cir Cardiovasc; 2007 Apr-Jun;22(2):160-8
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  • [Title] Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach.
  • OBJECTIVES: To report a surgical strategy for the Norwood procedure in the hypoplastic left heart syndrome (HLHS) that enables short hypothermic circulatory arrest time and aortic arch reconstruction with autologous pericardium patch.
  • Cannulation of the ductus arteriosus for systemic perfusion was the main part of the surgical strategy to reduce the hypothermic circulatory arrest time.
  • Hypothermic circulatory arrest times were 45.79+/-1.99 min and 36,8+/-1,52 min (p=0,0012), respectively.
  • CONCLUSIONS: This surgical strategy resulted in short circulatory arrest time, low mortality and low incidence of aortic coarctation.
  • [MeSH-major] Aortic Valve / surgery. Bioprosthesis. Heart Valve Prosthesis / standards. Hypoplastic Left Heart Syndrome / surgery. Pericardium / transplantation
  • [MeSH-minor] Anastomosis, Surgical. Brazil / epidemiology. Female. Heart Valve Prosthesis Implantation / mortality. Heart Ventricles / surgery. Humans. Infant, Newborn. Length of Stay. Male. Pulmonary Artery / surgery. Pulmonary Circulation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17992320.001).
  • [Journal-full-title] Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular
  • [ISO-abbreviation] Rev Bras Cir Cardiovasc
  • [Language] eng; por
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Brazil
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19. Apostolakis E, Shuhaiber JH: Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery. Expert Rev Cardiovasc Ther; 2007 Nov;5(6):1147-61
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  • [Title] Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery.
  • Three methods of cerebral protection have been applied between 1975 and today: hypothermic circulatory arrest as a basic method, either alone or with antegrade cerebral perfusion (ACP), or retrograde cerebral perfusion (RCP) as an adjunctive method.
  • ACP obtains a near-physiologic brain perfusion, with homogenous distribution of blood throughout the capillary beds, and extends the safe time of hypothermic circulatory arrest to 80 min, allowing the completion of whatever aortic arch work is necessary.

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  • (PMID = 18035930.001).
  • [ISSN] 1744-8344
  • [Journal-full-title] Expert review of cardiovascular therapy
  • [ISO-abbreviation] Expert Rev Cardiovasc Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 92
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20. Ge M, Zhao H, Wang W, Zhang Z, Yu X, Li W: Terahertz time-domain spectroscopy of four hydroxycinnamic acid derivatives. J Biol Phys; 2006 Nov;32(5):403-12
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  • The well-resolved absorption spectra of the hydroxycinnamic acid (HCA) derivatives, caffeic acid, ferulic acid, sinapic acid and chlorogenic acid, were measured over the frequency region from 0.3 to 2.0 THz at 294 K with terahertz time-domain spectroscopy (THz-TDS).
  • Theoretical calculation was applied to assist the analysis and assignment of the individual THz absorption spectra of the HCA derivatives with density functional theory (DFT).
  • The real and imaginary parts of dielectric function of the four HCA derivatives were also obtained.

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  • [Cites] J Phys Chem A. 2006 Feb 9;110(5):1951-9 [16451029.001]
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  • (PMID = 19669446.001).
  • [ISSN] 0092-0606
  • [Journal-full-title] Journal of biological physics
  • [ISO-abbreviation] J Biol Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2651536
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21. Flemming P, Lehmann U, Steinemann D, Kreipe H, Wilkens L: [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma]. Pathologe; 2006 Jul;27(4):238-43
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  • [Title] [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma].
  • [Transliterated title] Leberzelladenom. Entartungspotenzial und Abgrenzung vom hepatozellulären Karzinom.
  • In contrast to hepatocellular carcinoma (HCC), very few molecular pathological studies have been carried out on hepatocellular adenoma (HCA).
  • Particularly from the surgical point of view, based on views passed on verbally and in the literature of the 1970s and 1980s, a possible degeneration of the HCA provides grounds for operating.
  • Published cases of transitions from HCA into HCC were evaluated on the basis of today's morphological standards.
  • A comparison was made between the patterns of new molecular pathological studies of HCA, above all the work of our own groups, and those of HCC.
  • The results speak against the suggestion that a typical solitary HCA in pre-menopausal women is a precursor lesion of HCC.
  • After a critical review of the literature, only one casuistic case of a transition of HCA to HCC under a hormone therapy, which is no longer practiced today, remained.
  • A limitation of particular HCA in genetic and metabolic diseases, children, adult males, adenomatosis, and HCA-like tumors with known risk factors of HCC would seem pragmatically meaningful.
  • With classic HCA, however, the oncological indication for surgery does not apply.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 16736176.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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22. Duffin C: Healthcare assistants seen as more involved in patient care than nurses. Nurs Stand; 2006 Aug 16;20(49):5
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  • Patients have said that healthcare assistants (HCAs), not nurses, give most of the direct care they receive in hospital, research published in this week's Nursing Standard reveals.

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  • (PMID = 28086443.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Shum-Tim D, MacDonald D, Takayuki S, Laliberté E, Chen J, Jamal AM, Philip A, Platt R: Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest. Pediatr Crit Care Med; 2005 May;6(3):319-26
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  • [Title] Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest.
  • OBJECTIVE: The objective of this study was to evaluate the systemic and cerebral effects of different postoperative hematocrit management following cardiopulmonary bypass and deep hypothermic circulatory arrest.
  • INTERVENTIONS: Twelve piglets were subjected to cardiopulmonary bypass (hematocrit = 25%) and 100 mins of deep hypothermic circulatory arrest (15 degrees C).
  • Near-infrared spectroscopy and immunohistochemical assays for cerebral transforming growth factor-beta(1) and caspase-3 were performed.
  • CONCLUSIONS: Lower postoperative hematocrit was associated with increased fluid retention, lower perfusion pressure, and worse cerebrovascular injury following deep hypothermic circulatory arrest.
  • Postoperative hematocrit management may have profound systemic and cerebral effects after deep hypothermic circulatory arrest and merits further investigation.

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  • (PMID = 15857532.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Oxyhemoglobins; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 9008-02-0 / deoxyhemoglobin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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24. Halstead JC, Etz C, Meier DM, Zhang N, Spielvogel D, Weisz D, Bodian C, Griepp RB: Perfusing the cold brain: optimal neuroprotection for aortic surgery. Ann Thorac Surg; 2007 Sep;84(3):768-74; discussion 774
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  • We used a survival porcine model to explore the physiologic characteristics and behavioral benefits of various protocols involving hypothermic circulatory arrest (HCA) and SCP.
  • METHODS: Thirty pigs (26.3 +/- 1.4 kg), cooled to 15 degrees C on cardiopulmonary bypass, using alpha-stat pH management (mean hematocrit 30%), were randomly allocated to differing brain protection strategies: 90 minutes of HCA (group A); 30 minutes of HCA, then 60 minutes of SCP (group B); or 90 minutes of SCP (group C).
  • RESULTS: Cerebral blood flow was significantly higher (p = 0.0001) during SCP (60 and 90 minutes) if preceded by HCA.
  • However, an initial period of HCA does not seem to impair late outcome; perhaps the elevated CBF and CMRO2 observed reflect a beneficial cerebral response to a recoverable insult.
  • Clearly, 90 minutes of HCA induces permanent brain injury, even in this carefully controlled setting.
  • [MeSH-major] Aorta / surgery. Cerebrovascular Circulation. Heart Arrest, Induced

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  • (PMID = 17720373.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
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25. Huurman VA, Stoot JH, van der Linden E, Terpstra OT, Schaapherder AF: Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization. World J Gastroenterol; 2006 Oct 7;12(37):6059-61
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  • [Title] Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization.
  • This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma.
  • The bleeding was stopped by selective embolization of right hepatic artery branches.
  • The patient was discharged without complications, and subsequent follow-up until 22 mo after resection did not reveal any new lesions in the liver.
  • This case emphasizes the significance of selective arterial embolization in the management of bleeding liver tumors and questions the need for (partial) hepatectomy after this procedure in selective cases.
  • [MeSH-major] Adenoma, Liver Cell / complications. Embolization, Therapeutic / methods. Hemorrhage / therapy. Liver Neoplasms / complications
  • [MeSH-minor] Adult. Female. Hepatic Artery / pathology. Humans. Necrosis / pathology

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  • (PMID = 17009410.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4124419
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26. Brandt K, Langhans W, Geary N, Leonhardt M: Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet. Nutrition; 2006 Sep;22(9):905-12
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  • OBJECTIVE: The present study assessed whether long-term supplementation of a high-fructose diet with hydroxycitrate (HCA), an inhibitor of de novo lipogenesis that is widely used as a non-prescription dietary aid, decreases food intake, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats.
  • METHODS: We examined the effects of HCA (1.8% of diet) on food intake, body weight gain, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats during a 4-wk period of ad libitum access to a 50% fructose diet after a 3-wk period of food restriction in which they lost about 20% of their body weight.
  • RESULTS: HCA decreased food intake and weight gain throughout the test and reduced visceral fat accumulation compared with control rats fed ad libitum (CON).
  • Rats that were pair-fed (PF) to the HCA rats showed similar decreases in weight gain and visceral fat.
  • HCA did not ameliorate the hypertriglyceridemia induced by high-fructose feeding.
  • HCA improved insulin sensitivity on day 10 in comparison with CON rats, but by day 27 insulin levels were similarly higher and liver glycogen levels were similarly lower in HCA and CON rats in comparison with PF rats.
  • Liver lipid content was elevated in HCA rats compared with CON and PF rats.
  • CONCLUSION: These findings indicate that, although HCA attenuates body weight gain and visceral fat accumulation by reducing food intake under these conditions, it has no lasting beneficial effects on hypertriglyceridemia and hyperinsulinemia and leads to the accumulation of liver lipids.
  • [MeSH-major] Citrates / administration & dosage. Energy Intake / drug effects. Fructose / administration & dosage. Intra-Abdominal Fat / drug effects. Liver / metabolism. Weight Gain / drug effects

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  • (PMID = 16829028.001).
  • [ISSN] 0899-9007
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Citrates; 30237-26-4 / Fructose; 8W94T9026R / hydroxycitric acid
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27. Meybohm P, Hoffmann G, Renner J, Boening A, Cavus E, Steinfath M, Scholz J, Bein B: Measurement of blood flow index during antegrade selective cerebral perfusion with near-infrared spectroscopy in newborn piglets. Anesth Analg; 2008 Mar;106(3):795-803, table of contents
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  • BACKGROUND: Neonates with complex congenital heart defects have traditionally undergone surgery during deep hypothermic cardiac arrest (HCA).
  • We investigated SCP with different flow rates compared with HCA with respect to cerebral perfusion and tissue oxygenation as assessed by near-infrared spectroscopy.
  • METHODS: Twenty-one piglets were placed on cardiopulmonary bypass at 18 degrees C, then underwent either HCA or SCP at 25 or 50 mL x kg(-1) x min(-1) for 90 min.
  • RESULTS: Both BFI and FV(mean) increased significantly (126 +/- 27% of baseline; 19 +/- 2 cm/s) in the SCP 50 group compared with HCA (no flow) and SCP 25 (65 +/- 24%; 10 +/- 1 cm/s), respectively.
  • TOI increased in the SCP 50 group compared with baseline (74 +/- 4% vs 65 +/- 4%), and was higher compared with HCA (52 +/- 2%) and SCP 25 (59 +/- 2%).
  • CONCLUSIONS: Both BFI and FV(mean) suggested increased cerebral perfusion in the SCP 50 group compared with the HCA and SCP 25 groups.
  • TOI was significantly higher in both the SCP 25 and SCP 50 groups compared with HCA.
  • [MeSH-major] Brain / blood supply. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / adverse effects. Cerebrovascular Circulation. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Monitoring, Intraoperative / methods. Perfusion / methods. Spectroscopy, Near-Infrared


28. Nishimura O, Suzuki T, Hosoba S, Takashima N, Hiramatsu N, Kinoshita T, Kambara A, Matsubayashi K, Asai T: [Acute type A aortic dissection, developed shortly after aortic valve replacement and coronary artery bypass grafting]. Kyobu Geka; 2010 Dec;63(13):1141-4
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  • Under hypothermic circulatory arrest with femoral arterial and venous cannulations, the ascending aorta was replaced and re-implantation of the saphenous vein graft was carried out.
  • [MeSH-major] Aneurysm, Dissecting / etiology. Aortic Aneurysm, Thoracic / etiology. Coronary Artery Bypass. Heart Valve Prosthesis Implantation
  • [MeSH-minor] Acute Disease. Aged. Angina Pectoris / surgery. Aortic Valve Insufficiency / surgery. Humans. Male. Postoperative Complications. Reoperation

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  • (PMID = 21174664.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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29. De Francesco MA, Gargiulo F, Schreiber C, Ciravolo G, Salinaro F, Manca N: Detection and genotyping of human papillomavirus in cervical samples from Italian patients. J Med Virol; 2005 Apr;75(4):588-92
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  • In order to assess the epidemiological incidence and frequency of different HPV types, we applied a polymerase chain reaction (PCR)-direct sequencing approach based on the use of MY09/MY11 primers as compared to Hybrid Capture assay.
  • [MeSH-minor] Adolescent. Adult. Carcinoma in Situ / virology. Female. Genotype. Humans. Italy. Middle Aged. Sequence Analysis, DNA

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15714493.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Galloro V: Emory, HCA to end venture. Cultural differences, control cited as obstacles. Mod Healthc; 2010 Jul 19;40(29):16
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  • [Title] Emory, HCA to end venture. Cultural differences, control cited as obstacles.

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  • (PMID = 20695116.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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31. Mackiewicz V, Cammas A, Desbois D, Marchadier E, Pierredon S, Beaulieux F, Dussaix E, Vagner S, Roque-Afonso AM: Nucleotide variability and translation efficiency of the 5' untranslated region of hepatitis A virus: update from clinical isolates associated with mild and severe hepatitis. J Virol; 2010 Oct;84(19):10139-47
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  • To address the possible role of IRES variability in clinical presentation, IRES sequences were obtained from HAV isolates associated with benign (n = 8) or severe (n = 4) hepatitis.
  • IRES activity was assessed using a bicistronic dual-luciferase expression system in adenocarcinoma (HeLa) and hepatoma (HuH7) cell lines.
  • Activity was higher in HuH7 than in HeLa cells, except for an infrequently isolated genotype IIA strain.
  • No mutation was exclusive of benign or severe hepatitis, and variations in IRES activity were not associated with a clinical phenotype, indirectly supporting the preponderance of host factors in determining the clinical presentation.
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Base Sequence. Cell Line. Child. DNA Primers / genetics. DNA, Viral / genetics. France. Genetic Variation. Genotype. HeLa Cells. Humans. Middle Aged. Molecular Sequence Data. Mutagenesis, Site-Directed. Mutation. Nucleic Acid Conformation. Phylogeny. Protein Biosynthesis. Virulence / genetics. Young Adult

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  • (PMID = 20631141.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 5' Untranslated Regions; 0 / DNA Primers; 0 / DNA, Viral; 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC2937785
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32. De Felice C, Goldstein MR, Parrini S, Verrotti A, Criscuolo M, Latini G: Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis. Pediatr Crit Care Med; 2006 Mar;7(2):138-42
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  • OBJECTIVE: No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date.
  • PATIENTS AND INTERVENTION: Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
  • MEASUREMENTS AND MAIN RESULTS: Four different time series parameters were determined for nonlinear dynamical (NLD) analysis.
  • Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA.
  • Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
  • CONCLUSIONS: Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.
  • [MeSH-major] Chorioamnionitis / diagnosis. Chorioamnionitis / pathology. Infant, Premature

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  • (PMID = 16474255.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Trask OJ, Nickischer D, Burton A, Williams RG, Kandasamy RA, Johnston PA, Johnston PA: High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer. Methods Mol Biol; 2009;565:159-86
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  • [Title] High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer.
  • The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation through preclinical candidate selection.
  • In this chapter we describe the development, validation, and implementation of an HCS assay to screen compounds from a kinase-focused small-molecule library to identify inhibitors of the p38 pathway using the GE InCell 3000 automated imaging platform.
  • The assay utilized a genetically modified HeLa cell line stably expressing mitogen-activated, protein-activating protein kinase-2 fused to enhanced green fluorescent protein (MK2-EGFP) and measured the subcellular distribution of the MK2-EGFP as a direct readout of p38 activation.
  • The MK2-EGFP translocation assay performed in 384-well glass bottom microtiter plates exhibited a robust Z-factor of 0.46 and reproducible EC50 and IC50 determinations for activators and inhibitors, respectively.
  • Thirty-one compounds exhibited IC50s less than 1 microM, and at least one novel structural class of p38 inhibitor was identified using this HCA/HCS chemical biology screening approach.
  • [MeSH-major] Drug Evaluation, Preclinical / methods. Enzyme Inhibitors / analysis. Microscopy, Confocal / methods. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • [MeSH-minor] Calcium / metabolism. HeLa Cells. Humans

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  • (PMID = 19551362.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; SY7Q814VUP / Calcium
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34. Wu Y, Na N, Zhang S, Wang X, Liu D, Zhang X: Discrimination and identification of flavors with catalytic nanomaterial-based optical chemosensor array. Anal Chem; 2009 Feb 1;81(3):961-6
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  • Hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA) were used to analyze the patterns.
  • [MeSH-major] Flavoring Agents / analysis. Luminescent Measurements / methods. Nanostructures / chemistry
  • [MeSH-minor] Catalysis. Discriminant Analysis. Metal Nanoparticles / chemistry. Nanotubes, Carbon / chemistry. Temperature. Time Factors

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  • (PMID = 19119818.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flavoring Agents; 0 / Nanotubes, Carbon
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35. Basaran I, Sinan S, Cakir U, Bulut M, Arslan O, Ozensoy O: In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds. J Enzyme Inhib Med Chem; 2008 Feb;23(1):32-6
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  • These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.

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  • (PMID = 18341250.001).
  • [ISSN] 1475-6366
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coumarins; 0 / Enzyme Inhibitors; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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36. Choi JC, Baek YH, Jeong JS, Lee SW, Han SY, Cho JH: Discrete hypoechoic ring in hepatic cavernous hemangioma resembling a malignant tumor: correlation with histologic features. Gut Liver; 2009 Sep;3(3):226-30
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  • [Title] Discrete hypoechoic ring in hepatic cavernous hemangioma resembling a malignant tumor: correlation with histologic features.
  • Differential diagnoses of hepatic nodules include hepatocellular carcinoma, focal nodular hyperplasia, hepatic adenoma, regenerative nodule, focal fatty changes, and hemangioma.
  • We report herein the case of an atypical hemangioma presenting with a hypoechoic peripheral ring, mimicking a hepatic malignancy.

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  • (PMID = 20431752.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852708
  • [Keywords] NOTNLM ; Hemangioma / Hepatic malignancy / Hypoechoic ring / Ultrasonography
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37. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res; 2007 Oct;142(2):239-45
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  • Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells.
  • For in vitro studies, HCA-7 cells were treated with Ro26-2198 followed by interleukin-1beta (IL-1beta).
  • Proliferation was measured by WST-1 assay.
  • In vitro, Ro26-2198 inhibited IL-1beta-induced ERK activation and COX-2 induction and decreased HCA-7 cell proliferation.
  • [MeSH-minor] Animals. Anti-Inflammatory Agents / pharmacology. Cell Division / drug effects. Cell Line, Tumor. Colon / metabolism. Colon / pathology. Cyclooxygenase 2 / metabolism. Disease Models, Animal. Extracellular Signal-Regulated MAP Kinases / metabolism. Humans. Interleukin-1beta / pharmacology. MAP Kinase Signaling System / drug effects. Male. Mice. Mice, Inbred A. Proto-Oncogene Proteins c-myc / metabolism. Up-Regulation / drug effects

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  • (PMID = 17574271.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA036745; United States / NIDDK NIH HHS / DK / DK42086
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3; 0 / Anti-Inflammatory Agents; 0 / Interleukin-1beta; 0 / Proto-Oncogene Proteins c-myc; 1C6V77QF41 / Cholecalciferol; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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38. Ueda T, Taguchi S, Inoue Y, Kashima I: Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation. Interact Cardiovasc Thorac Surg; 2007 Feb;6(1):85-6
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  • [Title] Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation.
  • Surgical correction of adult complex aortic coarctation using hypothermic circulatory arrest often requires central cannulation to secure cerebral perfusion.
  • [MeSH-major] Aortic Coarctation / surgery. Heart Arrest, Induced. Hypothermia, Induced. Thoracotomy / methods

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  • (PMID = 17669776.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Terkivatan T, Ijzermans JN: Hepatocellular adenoma: Should phenotypic classification direct management? Nat Rev Gastroenterol Hepatol; 2009 Dec;6(12):697-8
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  • [Title] Hepatocellular adenoma: Should phenotypic classification direct management?
  • [MeSH-major] Adenoma, Liver Cell / classification. Adenoma, Liver Cell / metabolism. Liver Neoplasms / classification. Liver Neoplasms / metabolism

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  • (PMID = 19946304.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] England
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40. Muniz Filho RC, de Sousa SA, Pereira Fda S, Ferreira MM: Theoretical study of acid-catalyzed hydrolysis of epoxides. J Phys Chem A; 2010 Apr 22;114(15):5187-94
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  • By using chemometric tools, hierarchical cluster analysis (HCA), and principal component analysis (PCA), the MP2/6-311++G** level of theory was selected from HF, MP2, and DFT as the best method to describe the geometry of the basic skeleton (oxirane).
  • In the S(N)1 mechanism, the existence of the typical carbocation was not observed, and furthermore, the possibility of epoxide conversion to a protonated aldehyde was indicated, even in the presence of a water molecule (nucleophile).

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  • (PMID = 20334442.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Mazzei P, Francesca N, Moschetti G, Piccolo A: NMR spectroscopy evaluation of direct relationship between soils and molecular composition of red wines from Aglianico grapes. Anal Chim Acta; 2010 Jul 19;673(2):167-72
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  • The careful subtraction of water and ethanol signals from NMR spectra allowed to statistically recognize the metabolites to be employed in multivariate statistical methods: Principal Component Analysis (PCA), Discriminant Analysis (DA) and Hierarchical Clustering Analysis (HCA).
  • All multivariate analyses confirmed that the differentiation among the wines were related to micro-climate, and carbonate, clay, and organic matter content of soils.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20599031.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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42. Karni M, Bernasconi CF, Rappoport Z: Role of negative hyperconjugation and anomeric effects in the stabilization of the intermediate in SNV reactions. J Org Chem; 2008 Apr 18;73(8):2980-94
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  • The hyperconjugation ability (HCA) (i.e., the stabilization due to 2p(Calpha) --> sigma*(Cbeta-X) interaction) in 8b-8d follows the order (for X, kcal/mol) CH3S (8.5) > CF3CH2O (7.6) approximately CH3O (7.5).
  • The HCA in 8b-8d is significantly smaller than that in 7b-7d due to charge delocalization in Mu in the former.

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  • (PMID = 18376875.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Anderl JL, Redpath S, Ball AJ: A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity. J Vis Exp; 2009;(27)
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  • [Title] A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity.
  • High Content Analysis (HCA) assays combine cells and detection reagents with automated imaging and powerful image analysis algorithms, allowing measurement of multiple cellular phenotypes within a single assay.
  • In this study, we utilized HCA to develop a novel assay for neurotoxicity.
  • Recently, the application of HCA to neuronal screening has been reported.
  • By labeling neuronal cells with betaIII-tubulin, HCA assays can provide high-throughput, non-subjective, quantitative measurements of parameters such as neuronal number, neurite count and neurite length, all of which can indicate neurotoxic effects.
  • Astrocytes have an integral role in the maintenance of central nervous system (CNS) homeostasis, and are associated with both neuroprotection and neurodegradation when they are activated in response to toxic substances or disease states.
  • This approach is limited by an inability to provide information on cellular localization, morphology and cell number.
  • We determined that HCA could be used to overcome these limitations and to simultaneously measure multiple features associated with gliosis - changes in GFAP expression, astrocyte hypertrophy, and astrocyte proliferation - within a single assay.
  • Recent studies have suggested that the use of astrocytes in an in vitro neurotoxicity test system may prove more relevant to human CNS structure and function than neuronal cells alone.
  • Accordingly, we have developed an HCA assay for co-culture of neurons and astrocytes, comprised of protocols and validated, target-specific detection reagents for profiling betaIII-tubulin and glial fibrillary acidic protein (GFAP).
  • This assay enables simultaneous analysis of neurotoxicity, neurite outgrowth, gliosis, neuronal and astrocytic morphology and neuronal and astrocytic development in a wide variety of cellular models, representing a novel, non-subjective, high-throughput assay for neurotoxicity assessment.
  • The assay holds great potential for enhanced detection of neurotoxicity and improved productivity in neuroscience research and drug discovery.

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  • (PMID = 19417729.001).
  • [ISSN] 1940-087X
  • [Journal-full-title] Journal of visualized experiments : JoVE
  • [ISO-abbreviation] J Vis Exp
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3253581
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44. Jeon YK, Cheon JE, Kim SK, Wang KC, Cho BK, Park SH: Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol; 2008 Nov;21(11):1345-56
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  • [Title] Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization.
  • The presence of a pilomyxoid area was associated with shorter survival.
  • An unsupervised hierarchical clustering analysis classified the cases into three clusters: one pilomyxoid astrocytoma patient into one cluster, two pilomyxoid astrocytoma patients into another cluster, and six pilocytic astrocytoma patients and one pilomyxoid astrocytoma patient into the third cluster.
  • In conclusion, the presence of mixed-form pilomyxoid astrocytoma, the acquisition of pilocytic astrocytoma features in a recurrent tumor in pure-form pilomyxoid astrocytoma, and the above results of the genome-wide gene copy number analysis suggest that pilomyxoid astrocytoma might be a pathologically and genetically related, aggressive variant of pilocytic astrocytoma with partially different genetic alterations.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Brain / pathology. Child. Child, Preschool. Clone Cells. DNA, Neoplasm / genetics. Female. Humans. Immunoenzyme Techniques. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Survival Rate. Young Adult

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  • (PMID = 18622384.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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45. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR: Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res; 2007 May 15;67(10):4586-94
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  • [Title] Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.
  • Hepatocellular carcinoma (HCC) with p53 mutations is usually characterized by extensive chromosomal instability (CIN), whereas those with beta-catenin mutations have relatively less CIN and the molecular pathogenesis of these tumors is unknown.
  • Methylation of 21 genetic loci was quantitated using combined bisulfite restriction analysis.
  • Using hierarchical clustering analysis based upon the quantification of methylation levels, all HCCs were segregated into two groups characterized by either limited or extensive methylation.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Cell Transformation, Neoplastic / genetics. DNA Methylation. Liver Neoplasms / genetics. beta Catenin / genetics

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  • [ErratumIn] Cancer Res. 2007 Jun 15;67(12):5998. Ajay, Goel [corrected to Goel, Ajay]
  • (PMID = 17510384.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA72851; United States / NCI NIH HHS / CA / R01 CA98572
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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46. Panos A, Murith N, Bednarkiewicz M, Khatchatourov G: Axillary cerebral perfusion for arch surgery in acute type A dissection under moderate hypothermia. Eur J Cardiothorac Surg; 2006 Jun;29(6):1036-9
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  • Adequate brain protection is essential and commonly performed by either antegrade selective perfusion of the brachiocephalic arteries or an interval of profound hypothermic circulatory arrest.
  • The mean duration of circulatory arrest of the lower body and brain perfusion was 39.7 (range, 24-55 min).
  • CONCLUSIONS: The absence of any major permanent neurologic deficit or any visceral damages in our patients suggests that continuous moderate hypothermic cerebral perfusion, with an interval of circulatory arrest of the lower body, is adequate for acute type A aortic dissection surgery, allowing safe open repair of the distal aortic arch.
  • [MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Axillary Artery. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / methods. Catheterization, Peripheral / methods. Female. Humans. Male. Middle Aged. Perfusion / methods. Treatment Outcome

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  • [CommentIn] Eur J Cardiothorac Surg. 2006 Nov;30(5):815-6; author reply 816-7 [16956768.001]
  • [CommentIn] Eur J Cardiothorac Surg. 2006 Jun;29(6):1039-40 [16675223.001]
  • (PMID = 16675240.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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47. Hidayat W, Shakaff AY, Ahmad MN, Adom AH: Classification of agarwood oil using an electronic nose. Sensors (Basel); 2010;10(5):4675-85
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  • Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA), were used to classify different types of oil.
  • The HCA produced a dendrogram showing the separation of e-nose data into three different groups of oils.
  • [MeSH-major] Electronic Nose. Plant Oils / analysis. Thymelaeaceae / chemistry
  • [MeSH-minor] Algorithms. Cluster Analysis. Neural Networks (Computer). Odorants / analysis. Principal Component Analysis

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  • (PMID = 22399899.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Plant Oils
  • [Other-IDs] NLM/ PMC3292139
  • [Keywords] NOTNLM ; ANN (major topic) / HCA (major topic) / PCA (major topic) / agarwood oil (major topic) / dimensionality reduction (major topic) / e-nose (major topic)
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48. Meyers RL: Tumors of the liver in children. Surg Oncol; 2007 Nov;16(3):195-203
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  • [Title] Tumors of the liver in children.
  • In this review we examine the diagnosis and treatment of pediatric liver tumors- both malignant and benign.
  • The two most common malignant tumors are hepatoblastoma and hepatocellular carcinoma.
  • Hepatoblastoma is seen in younger children, hepatocellular carcinoma in older children.
  • Other malignant liver tumors are quite rare and include biliary rhabdomyosarcoma, angiosarcoma, rhabdoid tumor, and undifferentiated sarcoma.
  • The commonly seen benign liver tumors in children are infantile hemangioma, mesenchymal hamartoma, and focal nodular hyperplasia.
  • Rare benign tumors are hepatic adenoma, which is occasionally seen in teenage girls, and teratoma which is a very rare liver tumor in infants.
  • [MeSH-major] Liver Neoplasms

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  • (PMID = 17714939.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 69
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49. Kang M, Akbarali HI: Denitration of L-type calcium channel. FEBS Lett; 2008 Sep 3;582(20):3033-6
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  • Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa(v)1.2b.
  • Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca(v)1.2 in a 1D gel assay.
  • Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates.

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  • (PMID = 18675806.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK046367-17; United States / NIDDK NIH HHS / DK / R01 DK046367; United States / NIDDK NIH HHS / DK / DK46367; United States / NIDDK NIH HHS / DK / R01 DK046367-17
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CACNA1C protein, human; 0 / Calcium Channels, L-Type; 0 / Nitrates; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine
  • [Other-IDs] NLM/ NIHMS68998; NLM/ PMC2533528
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50. Yan S, Luo G, Wang Y, Cheng Y: Simultaneous determination of nine components in Qingkailing injection by HPLC/ELSD/DAD and its application to the quality control. J Pharm Biomed Anal; 2006 Mar 3;40(4):889-95
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  • This assay was fully validated in respect to precision, repeatability and accuracy.
  • The proposed method was successfully applied to quantify the nine ingredients in 19 different Qingkailing injection samples and by principal component analysis (PCA) and hierarchical clustering analysis (HCA), it demonstrated significant variations in the content of these compounds in the samples from different manufacturers and preparation procedures.
  • [MeSH-minor] Cluster Analysis. Light. Principal Component Analysis. Quality Control. Reproducibility of Results. Scattering, Radiation. Spectrophotometry, Ultraviolet

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  • (PMID = 16257167.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Qingkailing
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51. Galusca B, Dumollard JM, Lassandre S, Niveleau A, Prades JM, Estour B, Peoc'h M: Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Virchows Arch; 2005 Jul;447(1):18-23
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  • [Title] Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia.
  • The study aimed to evaluate the status of global DNA methylation in several types of thyroid tumors using a monoclonal antibody specific for 5-methylcytidine (5-mc) and to define the diagnosis potential of this marker.
  • 5-mc immunostaining scores were calculated in 17 papillary thyroid carcinomas (PTC), 6 follicular thyroid carcinomas (FTC), 16 follicular adenomas (FA), 19 nodular goiters (NG) and ten Hürthle cells adenomas (HCA).
  • Computerized image analysis showed a significant lower level of 5-mc immunostaining in thyroid carcinoma when compared with benign tumors or adjacent normal thyroid parenchyma (P<0.0001).
  • Overall, 5-mc accuracy to distinguish malign from benign thyroid tumors was similar to that of galectin-3 (89% versus 87%, P>0.05).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. DNA Methylation. Goiter, Nodular / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Epigenesis, Genetic. Galectin 3 / analysis. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Reproducibility of Results

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  • (PMID = 15891902.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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52. Kaakinen T, Alaoja H, Heikkinen J, Dahlbacka S, Laurila P, Kiviluoma K, Salomäki T, Tuominen H, Ohtonen P, Biancari F, Juvonen T: Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model. Ann Thorac Surg; 2006 Jan;81(1):183-90
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  • [Title] Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model.
  • In the present study we have assessed its potential neuroprotective efficacy in the setting of hypothermic circulatory arrest in a surviving porcine model.
  • METHODS: Twenty-four pigs were randomized to receive two 5-minute intravenous infusions (4 mL/kg) of either HSD (7.5 % saline, 6% dextran 70) or normal saline immediately after and 4 hours after a 75-minute period of hypothermic circulatory arrest at a brain temperature of 18 degrees C.
  • Intracranial pressure was lower in the HSD group from 45 minutes to 8 hours after hypothermic circulatory arrest (p = 0.03).
  • Cerebral perfusion pressure was higher in the HSD group from 45 minutes to 3 hours after hypothermic circulatory arrest (p = 0.06).
  • CONCLUSIONS: The use of HSD in experimental hypothermic circulatory arrest is associated with significantly better neurologic recovery, better histopathology, lower intracranial pressure, higher cerebral perfusion pressure, and better preservation of brain metabolism.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Dextrans / therapeutic use. Hypoxia-Ischemia, Brain / etiology. Neuroprotective Agents / therapeutic use. Reperfusion Injury / prevention & control. Saline Solution, Hypertonic / therapeutic use. Sodium Chloride / therapeutic use
  • [MeSH-minor] Animals. Behavior, Animal / drug effects. Body Temperature. Brain / pathology. Brain Chemistry. Cardiopulmonary Bypass / adverse effects. Drug Administration Schedule. Drug Evaluation, Preclinical. Female. Glucose / analysis. Infusions, Intravenous. Intracranial Pressure / drug effects. Lactates / analysis. Oxygen / analysis. Partial Pressure. Pyruvates / analysis. Random Allocation. Sus scrofa

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  • [CommentIn] Ann Thorac Surg. 2006 Jan;81(1):190 [16368361.001]
  • (PMID = 16368360.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Lactates; 0 / Neuroprotective Agents; 0 / Pyruvates; 0 / Saline Solution, Hypertonic; 0 / hypertonic saline-dextran solution; 451W47IQ8X / Sodium Chloride; IY9XDZ35W2 / Glucose; K3R6ZDH4DU / Dextrans; S88TT14065 / Oxygen
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53. Liu ZG, Sun LZ, Chang Q, Zhu JM, Dong C, Yu CT, Liu YM, Zhang HT: Should the "elephant trunk" be skeletonized? Total arch replacement combined with stented elephant trunk implantation for Stanford type A aortic dissection. J Thorac Cardiovasc Surg; 2006 Jan;131(1):107-13
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  • The stented graft, a 10-cm-long woven Dacron graft with a self-expandable stent, was implanted through the aortic arch during hypothermic circulatory arrest.
  • RESULTS: Cardiopulmonary bypass time was 166 +/- 38 minutes, and average selective cerebral perfusion and lower body arrest time was 30 +/- 15 minutes.
  • [MeSH-minor] Acute Disease. Adult. Aged. Cardiopulmonary Bypass. Chronic Disease. Female. Humans. Male. Middle Aged. Vascular Surgical Procedures / methods

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  • (PMID = 16399301.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Pele LC, Thoree V, Mustafa F, He S, Tsaprouni L, Punchard NA, Thompson RP, Evans SM, Powell JJ: Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis. J Nutr; 2007 Nov;137(11):2475-80
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  • [Title] Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis.
  • BALB/c mice received a normal Ca (NCa) diet (0.5% Ca), a high Ca (HCa) diet (1.5% Ca), a low Ca (LCa) diet (0.05% Ca), or a very low Ca (VLCa) diet (0.009% Ca) for 3 wk.
  • Half of the mice in each group received DSS (1.5%) for 20 d in their drinking water, and disease activity was assessed.
  • DSS-induced disease activity was higher in mice fed low dietary Ca levels [P < 0.0001, VLCa and DSS vs. NCa and DSS (NCaDSS) and P < 0.005, LCa and DSS vs. NCaDSS], and mice from the VLCa group were moribund within 11 d of DSS administration.
  • Those in the HCa group did not differ greatly from controls.
  • [MeSH-minor] Animals. Dextran Sulfate. Disease Models, Animal. Female. Inflammation. Mice. Mice, Inbred BALB C

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  • (PMID = 17951488.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105960399
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary; 9042-14-2 / Dextran Sulfate; EC 3.4.22.- / Caspases; SY7Q814VUP / Calcium
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55. Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ: Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis; 2007 May;28(5):940-6
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  • Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic BAs and an increase in BA pool size.
  • Surprisingly, at 12 months of age, male and female Fxr-null mice had a high incidence of degenerative hepatic lesions, altered cell foci and liver tumors including hepatocellular adenoma, carcinoma and hepatocholangiocellular carcinoma, the latter of which is rarely observed in mice.
  • They also had increased cell proliferation as revealed by increased PCNA mRNA and BrdU incorporation.


56. Colovic R, Grubor N, Micev M, Radak V: Hepatocellular adenoma with malignant alteration. Hepatogastroenterology; 2007 Mar;54(74):386-8
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  • [Title] Hepatocellular adenoma with malignant alteration.
  • Hepatocellular adenoma is a rare benign tumor of the liver which appears almost exclusively in women taking oral contraceptives.
  • With ultrasonography and CT scan a solitary well demarcated mass within the right liver of otherwise normal appearance was diagnosed.
  • During an open surgery a solitary, unilobular, spherical, well demarcated tumor on the lower surface of the segments IVb, V and VI of the liver, 115 x 100 x 90 mm in diameter was excised.
  • The histology revealed a hepatocellular adenoma with malignant alteration.
  • The patient is the eldest presented case of malignant alteration of hepatocellular adenoma who had never taken oral contraceptives or other hormones.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hepatectomy. Humans. Liver / pathology. Risk Factors. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 17523280.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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57. Abdo MR, Vullo D, Saada MC, Montero JL, Scozzafava A, Winum JY, Supuran CT: Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives. Bioorg Med Chem Lett; 2009 May 1;19(9):2440-3
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  • The compounds showed a weak hCA I activation profile, but were more efficient as hCA II and IX activators.
  • The 4-iodophenyl-substituted derivative behaved as a strong and isozyme selective hCA II activator, with an activation constant of 0.21muM.

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  • (PMID = 19345095.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Protein Isoforms; 0 / Recombinant Proteins; 0 / phenylsulfonylhydrazido l-histidine; 4QD397987E / Histidine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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58. Sinha R, Peters U, Cross AJ, Kulldorff M, Weissfeld JL, Pinsky PF, Rothman N, Hayes RB: Meat, meat cooking methods and preservation, and risk for colorectal adenoma. Cancer Res; 2005 Sep 1;65(17):8034-41
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  • [Title] Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
  • Cooking meat at high temperatures produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs).
  • Meat intake may increase cancer risk as HCAs, PAHs, and N-nitroso compounds are carcinogenic in animal models.
  • We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls.
  • The questionnaire was linked to a previously developed database to determine exposure to HCAs and PAHs.
  • Intake of red meat, with known doneness/cooking methods, was associated with an increased risk of adenoma in the descending and sigmoid colon [odds ratio (OR), 1.26; 95% confidence interval (95% CI), 1.05-1.50 comparing extreme quintiles of intake] but not rectal adenoma.
  • Well-done red meat was associated with increased risk of colorectal adenoma (OR, 1.21; 95% CI, 1.06-1.37).
  • Increased risks for adenoma of the descending colon and sigmoid colon were observed for the two HCAs: 2-amino-3,8-dimethylimidazo[4,5]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine (OR, 1.18; 95% CI, 1.01-1.38 and OR, 1.17, 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35).
  • Greater intake of bacon and sausage was associated with increased colorectal adenoma risk (OR, 1.14; 95% CI, 1.00-1.30); however, total intake of processed meat was not (OR, 1.04; 95% CI, 0.90-1.19).
  • Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma.
  • [MeSH-major] Adenoma / etiology. Colorectal Neoplasms / etiology. Cooking. Food Preservation. Meat

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  • (PMID = 16140978.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Mutagens; 0 / Quinoxalines; 3417WMA06D / Benzo(a)pyrene; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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59. Osborne-Bossert C, Fitzgerald D, Speir A, St Onge J: Delivery of antegrade cerebral perfusion during descending aortic reconstruction: a case report. Perfusion; 2008 Mar;23(2):135-7
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  • Antegrade cerebral perfusion (ACP) has been demonstrated to be a safe and effective method of providing adequate protection to the brain during hypothermic circulatory arrest.
  • By improving oxygen delivery to the cerebral capillaries, users of this technique have reported fewer temporary neurological deficits in postoperative periods, even after prolonged periods of circulatory arrest.
  • Surgical correction of a descending aortic aneurysm can provide a challenge when the left subclavian artery is involved.
  • A period of hypothermic circulatory arrest is required to complete the proximal anastamosis of the graft.
  • A 54-year-old female presented with a computerized tomography (CT) scan of a descending aortic aneurysm, originating at the base of the left subclavian artery.

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  • (PMID = 18840584.001).
  • [ISSN] 0267-6591
  • [Journal-full-title] Perfusion
  • [ISO-abbreviation] Perfusion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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60. Rhodes MC, Bucher JR, Peckham JC, Kissling GE, Hejtmancik MR, Chhabra RS: Carcinogenesis studies of benzophenone in rats and mice. Food Chem Toxicol; 2007 May;45(5):843-51
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  • There was a positive trend in the incidence of renal tubule adenoma in male rats; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Increased incidences of mononuclear cell leukemia were observed in male rats exposed to 312 or 625 ppm benzophenone and in female rats exposed to 625 ppm benzophenone.
  • Liver lesions observed included significantly increased incidences of hepatocytic centrilobular hypertrophy in all exposed groups of rats.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1250 ppm groups.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma.
  • There was equivocal evidence of carcinogenic activity of benzophenone in female F344/N rats based on the marginal increased incidences of mononuclear cell leukemia and histiocytic sarcoma.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F(1) mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F(1) mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F(1) mice may have been related to benzophenone exposure.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Animals. Dose-Response Relationship, Drug. Female. Histiocytic Disorders, Malignant / chemically induced. Histiocytic Disorders, Malignant / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia / chemically induced. Leukemia / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Rats. Rats, Inbred F344. Sarcoma / chemically induced. Sarcoma / pathology. Sex Factors

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  • (PMID = 17187913.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
  • [Other-IDs] NLM/ NIHMS21944; NLM/ PMC1936973
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61. Apostolakis EE, Baikoussis NG, Katsanos K, Karanikolas M: Postoperative peri-axillary seroma following axillary artery cannulation for surgical treatment of acute type A aortic dissection. J Cardiothorac Surg; 2010;5:43
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  • Right axillary artery cannulation confers significant advantages, because it provides antegrade arterial perfusion during cardiopulmonary bypass, and allows continuous antegrade cerebral perfusion during hypothermic circulatory arrest, thereby minimizing global cerebral ischemia.
  • We herein present the case of a 36-year-old Caucasian man with known Marfan syndrome and acute type A aortic dissection, who had direct right axillary artery cannulation for surgery of the ascending aorta.

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  • (PMID = 20500837.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2880968
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62. Kouchoukos NT, Masetti P, Mauney MC, Murphy MC, Castner CF: One-stage repair of extensive chronic aortic dissection using the arch-first technique and bilateral anterior thoracotomy. Ann Thorac Surg; 2008 Nov;86(5):1502-9
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  • METHODS: Fifty-one patients with chronic expanding thoracic aortic dissections (48 type A, 3 type B with proximal extension) were treated with a single procedure using a bilateral anterior thoracotomy, hypothermic circulatory arrest, and reperfusion of the arch vessels first to minimize brain ischemia.
  • Forty-six patients had previous operations: for acute type A aortic dissection (n = 36), aortic valve disease (n = 6), or coronary artery disease (n = 4).
  • CONCLUSIONS: The technique is a safe and suitable alternative to the two-stage (elephant trunk technique) and hybrid procedures for treatment of chronic dissection with aneurysm of the thoracic aorta.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Humans. Middle Aged. Recurrence. Reoperation. Survival Rate

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  • [CommentIn] Ann Thorac Surg. 2008 Nov;86(5):1509 [19049740.001]
  • (PMID = 19049739.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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63. Ambrosi DJ, Tanasijevic B, Kaur A, Obergfell C, O'Neill RJ, Krueger W, Rasmussen TP: Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells. Stem Cells; 2007 May;25(5):1104-13
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  • [Title] Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells.
  • The resulting hybrids are pluripotent as judged by developmental assays, but detailed analyses of the underlying molecular-genetic control of reprogrammed transcription in such hybrids are required to better understand fusion-mediated reprogramming.
  • Comprehensive analysis of the mouse embryonic fibroblast/ESC hybrid transcriptome revealed global patterns of gene expression reminiscent of ESCs.
  • However, combined analysis of variance and hierarchical clustering analyses revealed at least seven distinct classes of differentially regulated genes in comparisons of hybrids, ESCs, and somatic cells.
  • Somatic/ESC hybrid cell lines resemble their pre-fusion ESC partners in terms of behavior in culture and pluripotency.
  • [MeSH-major] Cellular Reprogramming / genetics. Chimera / genetics. Embryonic Stem Cells / metabolism. Genome
  • [MeSH-minor] Alleles. Animals. Base Sequence. Cell Line. Chromosomes, Mammalian / genetics. Cluster Analysis. DNA Mutational Analysis. Gene Expression Profiling. Gene Expression Regulation, Developmental. Karyotyping. Mice. Molecular Sequence Data. Pluripotent Stem Cells / metabolism. Transcription, Genetic

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  • (PMID = 17272499.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01AG23687
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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64. Baraki H, Hagl C, Khaladj N, Kallenbach K, Weidemann J, Haverich A, Karck M: The frozen elephant trunk technique for treatment of thoracic aortic aneurysms. Ann Thorac Surg; 2007 Feb;83(2):S819-23; discussion S824-31
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  • BACKGROUND: The frozen elephant trunk technique allows for single-stage repair of combined aortic arch and descending aortic aneurysms using a hybrid prosthesis with a stented and a nonstented end.
  • The stented end of the hybrid prosthesis was placed through the opened aortic arch under fluoroscopic control using hypothermic circulatory arrest and selective antegrade cerebral perfusion.
  • In 1 patient, the descending aorta was perforated owing to misplacement of the stented end of the hybrid prosthesis.

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  • (PMID = 17257934.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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65. Horiuchi S, Kumai R, Tokunaga Y, Tokura Y: Proton dynamics and room-temperature ferroelectricity in anilate salts with a proton sponge. J Am Chem Soc; 2008 Oct 8;130(40):13382-91
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  • Dielectric measurements revealed phase transitions at T(c) = 334 and 172 K for bromanilate (Hba(-)) and chloranilate (Hca(-)) salts, respectively.

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  • (PMID = 18781747.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Xie C, Mace J, Dinno MA, Li YQ, Tang W, Newton RJ, Gemperline PJ: Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy. Anal Chem; 2005 Jul 15;77(14):4390-7
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  • [Title] Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy.
  • We report on a rapid method for reagentless identification and discrimination of single bacterial cells in aqueous solutions using a combination of laser tweezers and confocal Raman spectroscopy (LTRS).
  • The optical trapping enables capturing of individual bacteria in aqueous solution in the focus of the laser beam and levitating the captured cell well off the cover plate, thus maximizing the excitation and collection of Raman scattering from the cell and minimizing the unwanted background from the cover plate and environment.
  • Raman spectral patterns excited by a near-infrared laser beam provide intrinsic molecular information for reagentless analysis of the optically isolated bacterium.
  • We show that synchronized bacterial cells can be well-discriminated among the six species using principal component analyses (PCA).
  • Unsynchronized bacterial cells that are cultured at stationary phases can also be well-discriminated by the PCA, as well as by a hierarchical cluster analysis (HCA) of their Raman spectra.
  • We also show that unsynchronized bacteria selected from random growth phases can be classified with the help of a generalized discriminant analysis (GDA).
  • These findings demonstrate that the LTRS may find valuable applications in rapid sensing of microbial cells in diverse aqueous media.
  • [MeSH-major] Bacteria / cytology. Optical Tweezers. Spectrum Analysis, Raman / instrumentation. Spectrum Analysis, Raman / methods

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  • (PMID = 16013851.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Solutions
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67. Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett; 2005 May 2;15(9):2359-64
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  • A series of such aromatic sulfonamides incorporating thioureido-sulfanilyl moieties has been prepared and investigated for its interaction with the catalytic domain of the human isozyme hCA IX.
  • Due to the highest expression of CA IX in clear renal cell carcinoma and its chemo/radioresistance, our efforts are first of all directed to generate effective therapeutic strategies for the cure of this malignancy.

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  • (PMID = 15837325.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carbonic Anhydrase Inhibitors; 0 / Sulfonamides; 8W8T17847W / Urea; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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68. Réti A, Barna G, Pap E, Adleff V, L Komlósi V, Jeney A, Kralovánszky J, Budai B: Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. Pathol Oncol Res; 2009 Sep;15(3):335-44
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  • [Title] Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
  • The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
  • Pharmacogenetic parameters were studied to characterize the 5-FU sensitivity of the two cell lines.
  • Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms were determined by PCR analysis.
  • Cell proliferation was measured by SRB assay, cell cycle distribution and apoptosis by FACS analysis.
  • The HT-29 cell line was found to be homozygous for TS 2R and 1494ins6 and T homozygous for MTHFR 677 polymorphisms predicting high 5-FU sensitivity (IC(50): 10 microM).
  • TS 3R homozygosity, TS 1496del6 and MTHFR 677CT heterozygosity may explain the modest 5-FU sensitivity (IC(50): 1.1 mM) of the HCA-7 cell line.
  • Indomethacin and NS-398 (10 microM and 1.77 microM, respectively) reduced the PGE(2) level in HCA-7 cells (>90%).
  • Low concentrations of NSAIDs without antiproliferative potency increased the S-phase arrest and enhanced the cytotoxic action of 5-FU only in HCA-7 cells after 48-hours treatment.
  • The presented data suggested that the enhancement of 5-FU cytotoxicity by indomethacin or NS-398 applied in low dose is related to the potency of NSAIDs to modulate the cell-cycle distribution and the apoptosis; however, it seems that this effect might be dependent on cell phenotype, namely on the COX-2 expression.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cell Proliferation / drug effects. Cyclooxygenase 2 / metabolism. Cyclooxygenase Inhibitors / pharmacology. Fluorouracil / pharmacology
  • [MeSH-minor] Apoptosis / drug effects. Blotting, Western. Cell Line, Tumor. Cell Separation. Enzyme-Linked Immunosorbent Assay. Flow Cytometry. HT29 Cells. Humans. Indomethacin / pharmacology. Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics. Microscopy, Fluorescence. Nitrobenzenes / pharmacology. Polymorphism, Genetic. Reverse Transcriptase Polymerase Chain Reaction. Sulfonamides / pharmacology. Thymidylate Synthase / genetics

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  • (PMID = 19048402.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.5.1.5 / Methylenetetrahydrofolate Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; U3P01618RT / Fluorouracil; XXE1CET956 / Indomethacin
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69. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. J Med Chem; 2005 Dec 1;48(24):7860-6
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  • A lately discovered carbonic anhydrase (hCA, EC 4.2.1.1), the mitochondrial hCA VB, was cloned, expressed, and purified.
  • Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a catalyst for the physiological reaction, with kcat = 9.5 x 10(5) s(-1) and kcat/K(M) = 9.8 x 10(7) M(-1) s(-1), being second only to hCA II among the 16 isoforms presently known in humans.
  • We investigated the inhibition of hCA VB with a library of sulfonamides/sulfamates, some of which are clinically used compounds.
  • Benzenesulfonamides were ineffective inhibitors, whereas derivatives bearing 4-amino, 4-hydrazino, 4-methyl, 4-carboxy moieties or halogenated sulfanilamides were more effective (Ki's of 1.56-4.3 microM).
  • Among the 10 clinically used compounds, acetazolamide, benzolamide, topiramate, and indisulam showed effective inhibitory activity (Ki's of 18-62 nM).
  • Three compounds showed better activity against hCA VB over hCA II, among which were sulpiride and ethoxzolamide, which were 2 times more effective inhibitors of the mitochondrial over the cytosolic isozyme. hCA VB is a druggable target and some of its inhibitors may lead to the development of novel antiobesity therapies.

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  • (PMID = 16302824.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides; 0 / Sulfonic Acids; 9NFU33906Q / sulfamic acid; EC 4.2.1.- / Carbonic Anhydrase V
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70. Reddy SK, Kishnani PS, Sullivan JA, Koeberl DD, Desai DM, Skinner MA, Rice HE, Clary BM: Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia. J Hepatol; 2007 Nov;47(5):658-63
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  • [Title] Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.
  • BACKGROUND/AIMS: Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing.
  • The objective of this retrospective study is to assess the safety and effectiveness of HCA resection in GSD Ia patients.
  • METHODS: Clinicopathologic, peri-operative, and long-term data were reviewed from patients who underwent HCA resection.
  • Comparisons were made with Fisher's exact, Mann-Whitney U, and log-rank tests; survival was estimated with Kaplan-Meier analysis.
  • RESULTS: From 1998 to 2006, 38 patients underwent HCA resection.
  • GSD Ia patients had greater morbidity (86% vs. 20%) and shorter time to adenoma progression (median 23 months vs. not yet reached) after partial hepatectomy compared to the general population (p<0.05).
  • Three GSD Ia patients underwent liver transplantation 77, 32, and 23 months after adenoma resection.
  • CONCLUSIONS: Despite substantial morbidity, partial hepatectomy is feasible in GSD Ia patients and is an effective intermediate step in the prevention of HCC until definitive treatment with liver transplantation.
  • [MeSH-major] Adenoma, Liver Cell / surgery. Biliary Tract Surgical Procedures / statistics & numerical data. Glycogen Storage Disease Type I / complications. Liver / surgery. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Disease Progression. Female. Humans. Liver Transplantation / statistics & numerical data. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17637480.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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71. Riesenman PJ, Tamaddon HS, Farber MA: Surgical bypass procedures to facilitate endovascular repair of aortic arch pathology. J Cardiovasc Surg (Torino); 2008 Aug;49(4):461-9
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  • Thoracic aortic lesions involving the aortic arch require more complex surgical interventions necessitating cardiopulmonary bypass, and hypothermic circulatory arrest.
  • The application of a thoracic endoprosthesis may be limited by the extent of involvement of the proximal thoracic aorta as coverage of arch vessel ostia may be necessary to obtain adequate proximal endograft fixation and aneurysm exclusion.
  • In an effort to overcome proximal landing zone limitations imposed by arch vessel involvement, hybrid surgical-endovascular reconstructive and debranching bypass procedures have been performed to create a proximal landing zone of adequate length.
  • Although these adjunctive techniques incorporate invasive surgical procedures, it is believed that minimizing the procedural invasiveness, by avoiding aortic cross-clamping and/or hypothermic circulatory arrest, morbidity and mortality outcomes can be improved especially in high-risk patients.
  • Several surgical approaches and techniques have been described for various levels of aortic arch involvement with encouraging early and mid-term results, although the long-term durability of these hybrid surgical-endovascular procedures remains to be defined.

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  • (PMID = 18665108.001).
  • [ISSN] 0021-9509
  • [Journal-full-title] The Journal of cardiovascular surgery
  • [ISO-abbreviation] J Cardiovasc Surg (Torino)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 50
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72. Hokaiwado N, Asamoto M, Ogawa K, Shirai T: Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol Pathol; 2005;33(6):695-701
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  • Transgenic rats featuring a dominant negative mutant of the connexin 32 gene under albumin promoter control (Cx32Delta Tg-High and Cx32Delta Tg-Low lines, respectively with high and low copy numbers of the transgene) have disrupted GJIC, as demonstrated by scrape dye-transfer assay in vivo as previous report by Asamoto et al. (2004).
  • However, incidences of adenomas and hepatocellular carcinomas were not elevated at the end of the experiment (52 weeks).
  • The results indicate that although both high and low expression of the dominant negative connexin 32 mutant gene in our rats is able to inhibit gap junctional capacity, only high expression is effective at enhancing susceptibility to early stage DEN-induced liver carcinogenesis.
  • [MeSH-major] Cell Communication / genetics. Gap Junctions / genetics. Glutathione Transferase / biosynthesis. Liver Neoplasms, Experimental / genetics. Precancerous Conditions / genetics
  • [MeSH-minor] Alkylating Agents. Animals. Animals, Genetically Modified. Cocarcinogenesis. Connexins / analysis. Connexins / genetics. Connexins / metabolism. Diethylnitrosamine. Disease Susceptibility. Enzyme Induction. Hepatectomy. Liver Regeneration / physiology. Male. Mutation. Phenobarbital / administration & dosage. Phenobarbital / pharmacology. Rats. Time Factors

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  • (PMID = 16243774.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkylating Agents; 0 / Connexins; 0 / connexin 32; 3IQ78TTX1A / Diethylnitrosamine; EC 2.5.1.18 / Glutathione Transferase; YQE403BP4D / Phenobarbital
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73. Fielding L: Current imaging strategies of primary and secondary neoplasms of the liver. Semin Intervent Radiol; 2006 Mar;23(1):3-12
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  • [Title] Current imaging strategies of primary and secondary neoplasms of the liver.
  • This article details the diagnosis and imaging of primary and secondary neoplasms of the liver.
  • Benign conditions that can mimic malignancy are also discussed, such as focal nodular hyperplasia and adenoma.
  • Considerable attention is given to hepatoma, which is the most common primary hepatic tumor in the United States.
  • Pitfalls in imaging related to posttreatment changes and unusual patterns of metastatic disease are illustrated.

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  • (PMID = 21326715.001).
  • [ISSN] 0739-9529
  • [Journal-full-title] Seminars in interventional radiology
  • [ISO-abbreviation] Semin Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3036312
  • [Keywords] NOTNLM ; Cancer / hepatoma / imaging / liver / metastasis
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74. Redline RW, Minich N, Taylor HG, Hack M: Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (&lt;1 kg). Pediatr Dev Pathol; 2007 Jul-Aug;10(4):282-92
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  • We conducted a secondary analysis of placental pathology in a cohort study of inborn singleton ELBW infants born between 1992 and 1995 and evaluated for cerebral palsy (CP) and abnormal neurocognitive testing at 8 years of age (N = 129).
  • Histologic chorioamnionitis (HCA) was not predictive of outcome in the population as a whole, but a severe fetal vascular response was associated with a lower NEPSY score in the subpopulation with HCA (N = 69).
  • Placentas with increased syncytial knots, villous edema, and those with neither finding constituted nonoverlapping subgroups with distinct pathologic and perinatal characteristics.
  • Among infants with villous edema (N = 25), those with neurologic impairment had lower gestational ages and more severe degrees of HCA.
  • However, by logistic regression these other factors were not independent risk factors for abnormal neurocognitive testing, and only HCA with a severe fetal vascular response decreased the association of villous edema with low test scores for NEPSY, but not K-ABC.

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  • [CommentIn] Pediatr Dev Pathol. 2008 Mar-Apr;11(2):164 [18422400.001]
  • (PMID = 17638433.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Joshi AD, Corral R, Siegmund KD, Haile RW, Le Marchand L, Martínez ME, Ahnen DJ, Sandler RS, Lance P, Stern MC: Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis; 2009 Mar;30(3):472-9
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  • Diets high in red meat have been consistently associated with colorectal cancer (CRC) risk and may result in exposure to carcinogens that cause DNA damage [i.e polycyclic aromatic hydrocarbons, heterocyclic amines (HCAs) and N-nitroso compounds].
  • We tested for gene-environment interactions using case-only analyses (n = 577) and compared the results using case-unaffected sibling comparisons (n = 307 sibships).
  • Case-unaffected sibling analyses were generally supportive of the case-only results.

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  • (PMID = 19029193.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA074799; United States / NIEHS NIH HHS / ES / 5P30 ES07048; United States / PHS HHS / / 5UO1074799
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens
  • [Other-IDs] NLM/ PMC2722151
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76. Weigelt B, Horlings HM, Kreike B, Hayes MM, Hauptmann M, Wessels LF, de Jong D, Van de Vijver MJ, Van't Veer LJ, Peterse JL: Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol; 2008 Oct;216(2):141-50
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  • We aimed to refine the breast cancer classification systems by analysing a series of 11 histological special types [invasive lobular carcinoma (ILC), tubular, mucinous A, mucinous B, neuroendocrine, apocrine, IDC with osteoclastic giant cells, micropapillary, adenoid cystic, metaplastic, and medullary carcinoma] using immunohistochemistry and genome-wide gene expression profiling.
  • Hierarchical clustering analysis confirmed that some histological special types constitute discrete entities, such as micropapillary carcinoma, but also revealed that others, including tubular and lobular carcinoma, are very similar at the transcriptome level.
  • Our analysis also revealed that some special types associated with a good prognosis, such as medullary and adenoid cystic carcinomas, display a poor prognosis basal-like transcriptome, providing strong circumstantial evidence that basal-like cancers constitute a heterogeneous group.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cluster Analysis. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Signal Transduction / genetics. Statistics, Nonparametric


77. Deneve JL, Pawlik TM, Cunningham S, Clary B, Reddy S, Scoggins CR, Martin RC, D'Angelica M, Staley CA, Choti MA, Jarnagin WR, Schulick RD, Kooby DA: Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann Surg Oncol; 2009 Mar;16(3):640-8
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  • [Title] Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy.
  • BACKGROUND: Liver cell adenoma (LCA) is a benign hepatic tumor with poorly characterized risk for spontaneous rupture and malignant transformation.
  • Patients with ruptured LCAs were more likely to require preoperative blood transfusion (32% vs. 9%, p=0.006), preoperative embolization (16% vs. 1%, p=0.021), and major (>or=3 segments) hepatic resection (65% vs. 32%, p=0.003).
  • By multivariate analysis, increasing tumor size (odds ratio (OR), 7.8; 95% confidence interval (CI), 2.2-26.3; p<0.01) and recent (within 6 months) hormone use (OR, 4.5; 95% CI, 1.5-13.3; p<0.01) remained independently associated with risk of rupture.
  • CONCLUSION: In this multicenter analysis of patients with LCAs, risk of rupture correlated with increasing tumor size and recent hormone use.
  • Rupture is associated with greater need for preoperative blood transfusion and major hepatic resection.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Erythrocyte Transfusion. Evidence-Based Practice. Female. Humans. Male. Postoperative Complications / diagnosis. Prospective Studies. Retrospective Studies. Risk Factors. Rupture, Spontaneous

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  • (PMID = 19130136.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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78. Coban TA, Beydemir S, Gülçin I, Ekinci D: Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biol Pharm Bull; 2007 Dec;30(12):2257-61
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  • Human erythrocyte isoenzymes, HCA-I and HCA-II, were purified by Sepharose-4B affinity chromatography column with a yield of 66.95 and 62.82%, a specific activity of 3892.3 and 11663.2 EU/mg proteins with 745.1 and 2232.6-fold purification of each isoenzyme, respectively.
  • In vitro inhibition of erythrocyte HCA-I and HCA-II by morphine using the CO(2)-hydratase enzyme gave IC(50) values 4.50 x 10(-5) M (r(2): 0.954) and 9.23 x 10(-5) M (r(2): 0.996), respectively.

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  • (PMID = 18057708.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Narcotics; 76I7G6D29C / Morphine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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79. Smith J, Roberts R, Fahy S: Use of study days to develop the healthcare assistant role. Nurs Times; 2006 Jul 25-31;102(30):34-5
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  • The Department of Health's strategies to combat staff shortages and an ageing workforce have now turned their focus to the delivery of patient care by HCAs.
  • This article describes how a trust redesigned the role of HCAs and implemented a study day in order to enhance both theoretical knowledge and clinical practice for this role.

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  • (PMID = 16903305.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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80. Neugebauer U, Schmid U, Baumann K, Ziebuhr W, Kozitskaya S, Holzgrabe U, Schmitt M, Popp J: The influence of fluoroquinolone drugs on the bacterial growth of S. epidermidis utilizing the unique potential of vibrational spectroscopy. J Phys Chem A; 2007 Apr 19;111(15):2898-906
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  • [Title] The influence of fluoroquinolone drugs on the bacterial growth of S. epidermidis utilizing the unique potential of vibrational spectroscopy.
  • In this work, vibrational spectroscopy is used to shed more light on the as-yet elusive interaction of gyrase inhibitors of the fluoroquinolone type with their biological target inside the Gram-positive bacterium Staphylococcus epidermidis by investigating whole-cell changes that occur as a result of the presence of the drug moxifloxacin.
  • The spectral changes caused by the action of the drug were analyzed with the help of statistical methods, such as hierarchical cluster analysis (HCA), principal component analysis (PCA), and Fisher's linear discriminant analysis (LDA) combined with variable selection.
  • The wavenumbers mostly affected by the action of the drug could be assigned to protein and DNA moieties, supporting the proposed mechanisms of a tertiary complex of the fluoroquinolone, the enzyme gyrase, and DNA.
  • [MeSH-minor] Aza Compounds / pharmacology. Cluster Analysis. DNA / metabolism. DNA Gyrase / metabolism. Models, Chemical. Models, Statistical. Principal Component Analysis. Quinolines / pharmacology. Spectrophotometry, Infrared. Spectrum Analysis, Raman. Time Factors. Ultraviolet Rays

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  • (PMID = 17385845.001).
  • [ISSN] 1089-5639
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Aza Compounds; 0 / Fluoroquinolones; 0 / Quinolines; 9007-49-2 / DNA; EC 5.99.1.3 / DNA Gyrase; U188XYD42P / moxifloxacin
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81. Neugebauer U, Schmid U, Baumann K, Ziebuhr W, Kozitskaya S, Deckert V, Schmitt M, Popp J: Towards a detailed understanding of bacterial metabolism--spectroscopic characterization of Staphylococcus epidermidis. Chemphyschem; 2007 Jan 8;8(1):124-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To fight disease and growing resistance, research interest is focused on understanding bacterial metabolism.
  • IR absorption spectroscopy reflects the overall chemical composition of the cells, with major focus on the protein vibrations.
  • Smaller sample volumes-down to a single cell-are sufficient to probe the overall chemical composition by means of micro-Raman spectroscopy.
  • In combination with statistical evaluation methods [hierarchical cluster analysis (HCA), principal component analysis (PCA), linear discriminant analysis (LDA)], the protein and nucleic-acid components that change during the different bacterial growth phases can be identified from the in vivo vibrational spectra.
  • Furthermore, tip-enhanced Raman spectroscopy (TERS) provides insight into the surface structures and follows the dynamics of the polysaccharide and peptide components on the bacterial cells with a spatial resolution below the diffraction limit.
  • [MeSH-major] Spectrophotometry, Infrared / methods. Spectrum Analysis, Raman / methods. Staphylococcus epidermidis / chemistry. Staphylococcus epidermidis / metabolism

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  • (PMID = 17146809.001).
  • [ISSN] 1439-4235
  • [Journal-full-title] Chemphyschem : a European journal of chemical physics and physical chemistry
  • [ISO-abbreviation] Chemphyschem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Nucleic Acids
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82. Correnti M, Cavazza ME, Herrera O, Rodríguez A: Presence of human papillomavirus infection determined by hybrid capture assay in cervical lesions in a Venezuelan population. Invest Clin; 2010 Mar;51(1):27-35
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  • [Title] Presence of human papillomavirus infection determined by hybrid capture assay in cervical lesions in a Venezuelan population.
  • The aim of this study was to establish the presence of HPV infection in cervical lesions in a Venezuelan population, by Hybrid Capture Assay II (HCA II), and its association with cytological diagnosis.
  • HPV infection was determined using HCA II.
  • The cytological diagnosis of the smears showed LSIL in 1120/1483 samples (75.5%), HSIL in 354/1483 (23.9%) and ASC-US, in 9/1483 (0.6%).
  • The positivity of HPV DNA detected by HCA II was 54.6% (811/1483).
  • Our study showed a high presence of cervical infection by human papillomavirus of a high risk genotype.
  • [MeSH-major] Papillomavirus Infections / diagnosis. Papillomavirus Infections / virology. Uterine Cervical Neoplasms / virology

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  • (PMID = 20815154.001).
  • [ISSN] 0535-5133
  • [Journal-full-title] Investigación clínica
  • [ISO-abbreviation] Invest Clin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Venezuela
  • [Chemical-registry-number] 0 / DNA Probes, HPV
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83. van Gulik TM, van den Esschert JW, Erdogan D, Vetelaïnen R: Hepatocellular adenomas. Liver Int; 2009 Apr;29(4):616
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  • [Title] Hepatocellular adenomas.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Disease Progression. Humans. Liver / pathology. Magnetic Resonance Imaging. Terminology as Topic

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  • [CommentOn] Liver Int. 2009 Jan;29(1):142 [18828785.001]
  • (PMID = 19323785.001).
  • [ISSN] 1478-3231
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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84. Wilkinson BL, Bornaghi LF, Houston TA, Innocenti A, Supuran CT, Poulsen SA: A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem; 2006 Nov 2;49(22):6539-48
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  • These compounds were assessed for their ability to inhibit three human CA isozymes in vitro: cytosolic hCA I and hCA II and transmembrane, tumor-associated hCA IX.
  • The qualitative structure-activity for all derivatives demonstrated that the stereochemical diversity present within the carbohydrate tails effectively interrogated the CA active site topology, to generate several inhibitors that were potent and selective toward hCA IX, an important outcome in the quest for potential cancer therapy applications based on CA inhibition.

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  • (PMID = 17064072.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzene Derivatives; 0 / Carbonic Anhydrase Inhibitors; 0 / Indicators and Reagents; 0 / Isoenzymes; 0 / Sulfonamides; 142M471B3J / Carbon Dioxide
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85. Xu L, Han X, Qi Y, Xu Y, Yin L, Peng J, Liu K, Sun C: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Anal Chim Acta; 2009 Feb 2;633(1):136-48
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  • [Title] Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
  • A simple and reliable high-performance liquid chromatography (HPLC) coupled with photodiode array detector (DAD) method was developed both for fingerprint analysis (FA) and quantitative determination.
  • In quantitative analysis, linear regressions, limit of detection (LOD) and quantification (LOQ), intra-day and inter-day precisions, recovery, repeatability and stability were all tested and good results were obtained to simultaneously determine the 15 marker compounds, namely chlorogenic acid, rhaponticin, 6,7-dimethoxycoumarin, naringin, hesperidin, neohesperidin, baicalin, wogonoside, baicalein, wogonin, chrysin, honokiol, magnolol, emodin, and chrysophanol in the herbal drugs.
  • In fingerprint analysis, 34 peaks were selected as the characteristic peaks to evaluate the similarities of different samples collected from different pharmaceutical companies in China according to the State Food and Drug Administration (SFDA) requirements, and two kinds of data, relative retention time (RRT) and relative peak area (RPA) were used to identify the common peaks in 15 samples for investigation.
  • Furthermore, hierarchical cluster analysis (HCA) was also performed to evaluate the variation of the herbal drugs.
  • [MeSH-major] Chromatography, High Pressure Liquid / methods. Drugs, Chinese Herbal / analysis

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  • (PMID = 19110127.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Solvents
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86. Budayova-Spano M, Fisher SZ, Dauvergne MT, Agbandje-McKenna M, Silverman DN, Myles DA, McKenna R: Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Acta Crystallogr Sect F Struct Biol Cryst Commun; 2006 Jan 1;62(Pt 1):6-9
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  • [Title] Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
  • Human carbonic anhydrase II (HCA II) is a zinc metalloenzyme that catalyzes the reversible hydration and dehydration of carbon dioxide and bicarbonate, respectively.
  • The rate-limiting step in catalysis is the intramolecular transfer of a proton between the zinc-bound solvent (H2O/OH-) and the proton-shuttling residue His64.
  • Despite the availability of high-resolution (approximately 1.0 A) X-ray crystal structures of HCA II, there is currently no definitive information available on the positions and orientations of the H atoms of the solvent network or active-site amino acids and their ionization states.
  • In preparation for neutron diffraction studies to elucidate this hydrogen-bonding network, perdeuterated HCA II has been expressed, purified, crystallized and its X-ray structure determined to 1.5 A resolution.
  • The refined structure is highly isomorphous with hydrogenated HCA II, especially with regard to the active-site architecture and solvent network.

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  • (PMID = 16511248.001).
  • [ISSN] 1744-3091
  • [Journal-full-title] Acta crystallographica. Section F, Structural biology and crystallization communications
  • [ISO-abbreviation] Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
  • [Language] ENG
  • [Databank-accession-numbers] PDB/ 2AX2/ R2AX2SF
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM025154; United States / NIGMS NIH HHS / GM / GM25154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Recombinant Proteins; AR09D82C7G / Deuterium; EC 4.2.1.- / Carbonic Anhydrase II
  • [Other-IDs] NLM/ PMC2150928
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87. Jia L, Wang S, Cao J, Zhou H, Wei W, Zhang J: siRNA targeted against matrix metalloproteinase 11 inhibits the metastatic capability of murine hepatocarcinoma cell Hca-F to lymph nodes. Int J Biochem Cell Biol; 2007;39(11):2049-62
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  • [Title] siRNA targeted against matrix metalloproteinase 11 inhibits the metastatic capability of murine hepatocarcinoma cell Hca-F to lymph nodes.
  • MMP-11 is strongly expressed in tumor cells and stromal fibroblasts located in the immediate vicinity of tumor.
  • This study investigated the possible role of MMP-11 expression in mouse hepatocarcinoma cell line Hca-F with highly lymphatic metastasis potential by RNA interference (RNAi) approach.
  • The results showed that a small interfering RNA (siRNA) targeted against MMP-11 significantly impeded Hca-F cells proliferation and colony formation in soft agar, as well as resulted in Hca-F cell apoptosis.
  • This reduction of MMP-11 expression also led to the decreased migration and adhesion of Hca-F cells dramatically both in vitro and in vivo.
  • Furthermore, in vivo metastasis assay indicated that down-regulation of MMP-11 expression in Hca-F cells attenuated the metastatic potential of Hca-F cells to peripheral lymph nodes.
  • [MeSH-major] Carcinoma, Hepatocellular / enzymology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / enzymology. Liver Neoplasms / pathology. Lymph Nodes / pathology. Matrix Metalloproteinase Inhibitors. RNA, Small Interfering / pharmacology
  • [MeSH-minor] Animals. Apoptosis / drug effects. Cell Adhesion / drug effects. Cell Line, Tumor. Cell Movement / drug effects. Cell Proliferation / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Gene Silencing. Immunohistochemistry. Matrix Metalloproteinase 11 / genetics. Matrix Metalloproteinase 11 / metabolism. Mice. Neoplasm Metastasis. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 17627864.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Matrix Metalloproteinase Inhibitors; 0 / RNA, Messenger; 0 / RNA, Small Interfering; EC 3.4.24.- / Matrix Metalloproteinase 11
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88. Skerman HM, Yates PM, Battistutta D: Multivariate methods to identify cancer-related symptom clusters. Res Nurs Health; 2009 Jun;32(3):345-60
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  • Conceptually, common factor analysis (FA) and hierarchical cluster analysis (HCA) are appropriate for symptom cluster identification, not principal component analysis.
  • As a basis for new directions in symptom management, FA methods are more appropriate than HCA.
  • [MeSH-major] Cluster Analysis. Cross-Sectional Studies. Data Interpretation, Statistical. Multivariate Analysis. Neoplasms / complications. Nursing Research / methods
  • [MeSH-minor] Decision Support Techniques. Factor Analysis, Statistical. Guidelines as Topic. Humans. Likelihood Functions. Nursing Assessment. Principal Component Analysis. Regression Analysis. Reproducibility of Results. Research Design

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc.
  • (PMID = 19274688.001).
  • [ISSN] 1098-240X
  • [Journal-full-title] Research in nursing & health
  • [ISO-abbreviation] Res Nurs Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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89. Kim YS, Eun H, Cho HS, Kim KS, Watanabe E, Baba K, Katase T: The characterization of PCDDs, PCDFs and coplanar PCBs during the past 50 years in Gwangyang Bay, South Korea. J Hazard Mater; 2008 Jun 15;154(1-3):756-65
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  • The dioxin in the sediment samples was found to come from a mixture of the impurities of pentachlorophenol (PCP), chloronitrofen (CNP) and combustion based on the result of hierarchical cluster analysis (HCA).
  • According to principal component analysis (PCA) related to the Kow values for the congener-specific composition of co-PCBs in the sediment core, the Kanechlor (KC)-500 and the atmospheric deposition were identified as the possible sources.
  • [MeSH-major] Benzofurans / analysis. Geologic Sediments / analysis. Polychlorinated Biphenyls / analysis. Tetrachlorodibenzodioxin / analogs & derivatives. Water Pollutants, Chemical / analysis

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  • (PMID = 18063300.001).
  • [ISSN] 0304-3894
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Water Pollutants, Chemical; 0 / chlorinated dibenzofurans; 0 / polychlorodibenzo-4-dioxin; DFC2HB4I0K / Polychlorinated Biphenyls; DO80M48B6O / Tetrachlorodibenzodioxin
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90. Lu LS, Wu CC, Hung LM, Chiang MT, Lin CT, Lin CW, Su MJ: Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia. Liver Int; 2007 May;27(4):529-37
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  • [Title] Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia.
  • BACKGROUND: This study addressed the effects of apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, on hepatic oxidative burden and liver injury during diet-induced hypercholesterolaemia.
  • The high-cholesterol diet (HC) significantly increased the serum level of cholesterol and hepatic cholesterol ester deposition, and these parameters were similar between the HC and high-cholesterol diet plus apocynin (HCA) groups.
  • The HC group showed abnormal liver function tests [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (Alk-P)] as well as increased Evans blue extravasation and macrophages infiltration.
  • Biochemical analysis of redox status including thiobarbituric acid reactive substances, reduced glutathione, and oxidized glutathione also confirmed the phenomenon.
  • CONCLUSIONS: We concluded that apocynin suppressed NADPH oxidase activation and subsequent liver injuries owing to high-cholesterol intake in rats.
  • [MeSH-major] Acetophenones / pharmacology. Hypercholesterolemia / complications. Hypercholesterolemia / drug therapy. Liver Diseases / prevention & control. Oxidative Stress / drug effects
  • [MeSH-minor] Animals. Antioxidants. Cholesterol / administration & dosage. Cholesterol / blood. Hepatocytes. Inflammation / prevention & control. Liver Function Tests. Male. NADPH Oxidase. Oxidation-Reduction. Rats. Rats, Wistar

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  • (PMID = 17403193.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acetophenones; 0 / Antioxidants; 97C5T2UQ7J / Cholesterol; B6J7B9UDTR / acetovanillone; EC 1.6.3.1 / NADPH Oxidase
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91. Bosley S, Dale J: Healthcare assistants in general practice: practical and conceptual issues of skill-mix change. Br J Gen Pract; 2008 Feb;58(547):118-24
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  • The emergence of healthcare assistants (HCAs) in general practice raises questions about roles and responsibilities, patients' acceptance, cost-effectiveness, patient safety and delegation, training and competence, workforce development, and professional identity.
  • There has been minimal research into the role of HCAs and their experiences, as well as those of other staff working with HCAs in general practice.
  • Drawing on the limited research in general practice, the challenges and benefits of developing the HCA role in general practice are discussed.
  • It is concluded that HCAs can make an increasingly useful contribution to the skill mix in general practice, but that more research and evaluation are needed to inform their training and development within the general practice team.
  • [MeSH-minor] Cost-Benefit Analysis. Humans. Safety Management

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  • (PMID = 18307856.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2233962
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92. Zou P, Hong Y, Koh HL: Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis. J Pharm Biomed Anal; 2005 Jul 1;38(3):514-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis.
  • Hierarchical clustering analysis gave similar results as the visual comparison.
  • This is the first report of hierarchical clustering analysis of I. indigotica root.
  • [MeSH-major] Chromatography, High Pressure Liquid / methods. Cluster Analysis. Isatis / chemistry. Plant Extracts / analysis. Plant Roots / chemistry
  • [MeSH-minor] Drugs, Chinese Herbal / analysis. Drugs, Chinese Herbal / chemistry. Indigo Carmine. Indoles / analysis. Molecular Structure. Powders. Reference Standards. Reproducibility of Results. Technology, Pharmaceutical / methods

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  • (PMID = 15925253.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Indoles; 0 / Plant Extracts; 0 / Powders; D3741U8K7L / Indigo Carmine; V86L8P74GI / indirubin
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93. Givehchian M, Beschorner R, Ehmann C, Frauenlob L, Morgalla M, Hashemi B, Ziemer G, Scheule AM: Neuroprotective effects of erythropoietin during deep hypothermic circulatory arrest. Eur J Cardiothorac Surg; 2010 Mar;37(3):662-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroprotective effects of erythropoietin during deep hypothermic circulatory arrest.
  • Using a surviving porcine model, this study evaluates whether systemic treatment with erythropoietin induces brain protection in deep hypothermic circulatory arrest (DHCA).
  • CONCLUSION: These results suggest some beneficial neuroprotective effects of erythropoietin in this model of global brain ischaemia induced by 1h of hypothermic circulatory arrest.
  • [MeSH-major] Erythropoietin / therapeutic use. Heart Arrest, Induced / adverse effects. Hypoxia-Ischemia, Brain / prevention & control. Neuroprotective Agents / therapeutic use
  • [MeSH-minor] Animals. Brain / metabolism. Disease Models, Animal. Drug Evaluation, Preclinical. Hemodynamics / physiology. Hypothermia, Induced / adverse effects. Intracranial Pressure / drug effects. Oxygen Consumption / drug effects. Perioperative Care / methods. Random Allocation. Recombinant Proteins. Sus scrofa

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  • [Copyright] Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 19766506.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neuroprotective Agents; 0 / Recombinant Proteins; 11096-26-7 / Erythropoietin
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94. Brzozowski Z, Sławiński J, Saczewski F, Innocenti A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. Eur J Med Chem; 2010 Jun;45(6):2396-404
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  • Against the human isozymes hCA I, the new compounds showed inhibition constants in the range of 0.078-11.7 microM, against hCA II in the range of 9.9-140 nM, against hCA IX in the range of 4.6-313 nM, against hCA XII in the range of 3.4-21.6 nM, and against hCA XIV in the range of 50.9-160 nM, respectively.
  • Compounds 4, 6, 7, 9, 11-14, 19, 20, 22-24, 26, 27, 31 and 32 showed excellent hCA IX inhibitory efficacy, with inhibition constants of 4.6-12.0 nM, being much more effective as compared to the clinically used sulfonamides AAZ, MZA, EZA, DCP and IND.
  • 4-[N'-(6-chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide (31) is the prominent of the compounds due to its remarkable inhibitory activity toward hCA I (KIs=0.078 microM), hCA IX (KIs=7.2 nM) and hCA XII (KIs=3.4 nM).

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20202722.001).
  • [ISSN] 1768-3254
  • [Journal-full-title] European journal of medicinal chemistry
  • [ISO-abbreviation] Eur J Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; EC 4.2.1.1 / carbonic anhydrase XII; EC 4.2.1.1 / carbonic anhydrase XIV
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95. Gouw AS, Zeng W, Buiskool M, Platteel I, van den Heuvel MC, Poppema S, de Jong KP, Molema G: Molecular characterization of the vascular features of focal nodular hyperplasia and hepatocellular adenoma: a role for angiopoietin-1. Hepatology; 2010 Aug;52(2):540-9
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  • [Title] Molecular characterization of the vascular features of focal nodular hyperplasia and hepatocellular adenoma: a role for angiopoietin-1.
  • Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are two hepatic nodular lesions of different etiologies.
  • FNH, a polyclonal lesion, is assumed to be a regenerative reaction following a vascular injury, whereas HCA is a monoclonal, benign neoplastic lesion.
  • In addition to features that are predominantly found in either FNH or HCA (e.g., dystrophic vessels in FNH and single arteries in HCA), FNH and HCA share morphological vascular abnormalities such as dilated sinusoids.
  • This was based on reports of morphologically abnormal hepatic vasculature and nodular lesions in transgenic models of hepatocytic overexpression of angiopoietin-1 (Ang-1), a member of the angiopoietin family, which is crucially involved in vascular morphogenesis and homeostasis.
  • We investigated gene and protein expression of members of the angiopoietin system and vascular endothelial growth factor A (VEGF-A) and its receptors in 9 FNH samples, 13 HCA samples, and 9 histologically normal livers.
  • In comparison with normal samples, a significant increase in Ang-1 was found in FNH (P < 0.01) and HCA (P < 0.05), whereas no significant changes in Ang-2, receptor tyrosine kinase with immunoglobulin-like and EGF-like domains 2, VEGF-A, or vascular endothelial growth factor receptor 2 (VEGFR-2) were observed.
  • CONCLUSION: Because of the different etiological contexts of a preceding vascular injury in FNH and a neoplastic growth in HCA, Ang-1 might exert different effects on the vasculature in these lesions.
  • In FNH, it could predominantly stimulate recruitment of myofibroblasts and result in dystrophic vessels, whereas in HCA, it may drive vascular remodeling that produces enlarged vessels and arterial sprouting that generates single arteries.
  • [MeSH-major] Adenoma, Liver Cell / blood supply. Angiopoietin-1 / physiology. Focal Nodular Hyperplasia / pathology. Liver Neoplasms / blood supply

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  • (PMID = 20683953.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiopoietin-1
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96. Wilkinson BL, Bornaghi LF, Houston TA, Innocenti A, Vullo D, Supuran CT, Poulsen SA: Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett; 2007 Feb 15;17(4):987-92
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  • A library of glycoconjugate benzenesulfonamides that contain diverse carbohydrate-triazole tails were investigated for their ability to inhibit the enzymatic activity of the three human transmembrane carbonic anhydrase (CA) isozymes hCA IX, hCA XII and hCA XIV.
  • These isozymes have their CA domains located extracellularly, unlike the physiologically dominant hCA II, and are of immense current interest as druggable targets.
  • Elevated expression of isozymes IX and XII is a marker for a broad spectrum of hypoxic tumors-this physiology may facilitate a novel approach to discriminate between healthy cells and cancerous cells.
  • The most potent hCA IX inhibitor was the glucuronic acid derivative 20 (K(i)=23nM).
  • This compound was uniquely hCA IX selective cf. all other isozymes (16.4-, 16.8- and 4.6-fold selective against hCA II, XII, and XIV, respectively).
  • At hCA XII there were many inhibitors with K(i)s<10nM that also demonstrated excellent selectivity (up to 344-fold) against other isozymes.
  • Potent hCA XIV inhibitors were also identified, several with K(i)s approximately 10nM, however no hCA XIV-selective derivatives were evidenced from this library.

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  • (PMID = 17157501.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Glycoconjugates; 0 / Isoenzymes; 0 / Recombinant Proteins; 0 / Sulfonamides; I6G9Y0J1OJ / Phenolsulfonphthalein
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97. Wong V, Wang DY, Warren K, Kulkarni S, Boerner S, Done SJ, Leong WL: The effects of timing of fine needle aspiration biopsies on gene expression profiles in breast cancers. BMC Cancer; 2008;8:277
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  • BACKGROUND: DNA microarray analysis has great potential to become an important clinical tool to individualize prognostication and treatment for breast cancer patients.
  • Our study examines one variable that is often overlooked, the timing of tissue acquisition, which may have a significant impact on the outcomes of DNA microarray analyses especially in studies that compare microarray data based on biospecimens taken in vivo and ex vivo.
  • RESULTS: Using hierarchical clustering analysis, 12 genes were found to be differentially expressed between the FNABs taken before and after surgical removal.
  • CONCLUSION: Our study demonstrated that the timing of fine needle aspiration biopsies can be a confounding factor in microarray data analyses in breast cancer.
  • [MeSH-minor] Adult. Biomarkers, Tumor. Breast / metabolism. Breast / pathology. Cell Hypoxia. Cluster Analysis. Female. Genes, fos. Humans. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. Time Factors

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  • (PMID = 18826606.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2567989
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98. Suh YH, Kim Y, Bang JH, Choi KS, Lee JW, Kim WH, Oh TJ, An S, Jung MH: Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats. J Mol Endocrinol; 2005 Apr;34(2):299-315
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  • [Title] Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats.
  • Insulin resistance occurs early in the disease process, preceding the development of type 2 diabetes.
  • Therefore, the identification of molecules that contribute to insulin resistance and leading up to type 2 diabetes is important to elucidate the molecular pathogenesis of the disease.
  • To this end, we characterized gene expression profiles from insulin-sensitive tissues, including adipose tissue, skeletal muscle, and liver tissue of Zucker diabetic fatty (ZDF) rats, a well characterized type 2 diabetes animal model.
  • Differentially regulated genes demonstrating > 1.3-fold change at age were identified and categorized through hierarchical clustering analysis.
  • Our results showed that while expression of lipolytic genes was elevated in adipose tissue of diabetic ZDF rats at 12 weeks of age, expression of lipogenic genes was decreased in liver but increased in skeletal muscle of 12 week old diabetic ZDF rats.
  • These results suggest that impairment of hepatic lipogenesis accompanied with the reduced lipogenesis of adipose tissue may contribute to development of diabetes in ZDF rats by increasing lipogenesis in skeletal muscle.
  • Moreover, expression of antioxidant defense genes was decreased in the liver of 12-week old diabetic ZDF rats as well as in the adipose tissue of ZDF rats both at 6 and 12 weeks of age.
  • Cytochrome P450 (CYP) genes were also significantly reduced in 12 week old diabetic liver of ZDF rats.
  • Genes involved in glucose utilization were downregulated in skeletal muscle of diabetic ZDF rats, and the hepatic gluconeogenic gene was upregulated in diabetic ZDF rats.
  • [MeSH-minor] Age Factors. Animals. Antioxidants / physiology. Cytochrome P-450 Enzyme System / genetics. Cytochrome P-450 Enzyme System / metabolism. Lipid Metabolism. Liver / physiology. Male. Molecular Sequence Data. Oligonucleotide Array Sequence Analysis. RNA / genetics. RNA / metabolism. Rats. Rats, Zucker

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  • (PMID = 15821098.001).
  • [ISSN] 0952-5041
  • [Journal-full-title] Journal of molecular endocrinology
  • [ISO-abbreviation] J. Mol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Insulin; 63231-63-0 / RNA; 9035-51-2 / Cytochrome P-450 Enzyme System
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99. Merchant NB, Rogers CM, Trivedi B, Morrow J, Coffey RJ: Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery; 2005 Sep;138(3):415-21
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  • [Title] Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells.
  • We have shown that activation of the EGFR induces up-regulation of cyclooxygenase 2, basolateral release of prostaglandins (PGs), and mitogenesis in a polarizing human colon cancer cell line, HCA-7.
  • The purpose of this study was to determine the mechanism by which DCA activates EGFR in human polarizing CRC cell lines HCA-7 and HCT-8.
  • METHODS: A primary, non-tumor-promoting bile acid (cholic acid [CA]) and a secondary, tumor-promoting bile acid, DCA, were added to the apical and basolateral compartment of polarized HCA-7 and HCT-8 cells.
  • These cells were pretreated with monoclonal antibody 528, a monoclonal antibody that inhibits ligand binding to EGFR, or with WAY-022, a selective inhibitor of tumor necrosis factor-alpha converting enzyme/a disintegrin and metalloprotease-17 (TACE/ADAM-17), which cleaves amphiregulin (AR) to its mature, soluble form from the basolateral cell membrane.
  • AR levels were measured in the apical and basolateral medium and cell lysates by radioimmunoassay.
  • RESULTS: Basolateral delivery of DCA, but not CA, preferentially stimulated release of AR into the basolateral medium compared with cell lysates of polarized HCA-7 and HCT-8 cells.
  • Inhibiting cell surface cleavage of AR with WAY-022 before DCA treatment reduced AR (P < .05) and PGE2 (P < .05) levels in the basolateral medium.
  • The mechanism of DCA-induced EGFR activation is ligand-dependent and is controlled, at least in part, at the level of AR release from the basolateral cell membrane.
  • [MeSH-minor] Amphiregulin. Cell Line, Tumor. Cell Membrane / drug effects. Cell Membrane / physiology. Cell Polarity / drug effects. Cholic Acid / pharmacology. EGF Family of Proteins. Glycoproteins / secretion. Humans. Intercellular Signaling Peptides and Proteins / secretion. Ligands. Radioimmunoassay

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  • (PMID = 16213893.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46413; United States / NCI NIH HHS / CA / P50CA95103
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AREG protein, human; 0 / Amphiregulin; 0 / Bile Acids and Salts; 0 / EGF Family of Proteins; 0 / Glycoproteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ligands; 005990WHZZ / Deoxycholic Acid; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; G1JO7801AE / Cholic Acid
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100. Ibrahim S, Chen CL, Wang SH, Lin CC, Yang CH, Yong CC, Jawan B, Cheng YF: Liver resection for benign liver tumors: indications and outcome. Am J Surg; 2007 Jan;193(1):5-9
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  • [Title] Liver resection for benign liver tumors: indications and outcome.
  • BACKGROUND: The indications for intervention in cases of benign liver tumors include symptoms, suspicion of malignancy, or risk of malignant change.
  • METHODS: Eighty-four liver resections for benign tumors were performed in our hospital from June 1996 to December 2004.
  • RESULTS: The study group (41 females, 43 males; average age, 41.4 +/- 10.5 y) included 46 cavernous hemangiomas, 27 focal nodular hyperplasias, 5 hepatic adenomas, and 6 liver cysts.
  • CONCLUSIONS: Liver resection for benign liver tumor is safe, but indications for intervention must be evaluated carefully.
  • The presence of chronic parenchymal liver disease does not increase morbidity in these patients.
  • [MeSH-major] Hepatectomy / adverse effects. Hepatitis B / etiology. Liver Diseases / etiology. Liver Neoplasms / surgery
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / surgery. Adult. Chronic Disease. Cysts / diagnosis. Cysts / surgery. Female. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / surgery. Humans. Hyperplasia. Liver / pathology. Male. Retrospective Studies

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  • (PMID = 17188079.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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