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1. Chatzoulis G, Kaltsas A, Daliakopoulos S, Sallam O, Maria K, Chatzoulis K, Pachiadakis I: Co-existence of a giant splenic hemangioma and multiple hepatic hemangiomas and the potential association with the use of oral contraceptives: a case report. J Med Case Rep; 2008;2:147

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Co-existence of a giant splenic hemangioma and multiple hepatic hemangiomas and the potential association with the use of oral contraceptives: a case report.
  • INTRODUCTION: Hepatic and splenic hemangiomas are common benign tumors that mainly affect female patients.
  • Giant splenic hemangiomas are extremely rare, especially when correlated with multiple hepatic hemangiomas.
  • Pathogenetic mechanisms between hemangiomas and oral contraceptives, as well as therapeutic approaches, are analyzed in this case report, in particular for the management of synchronous splenic and hepatic hemangiomas.
  • CASE PRESENTATION: We report here a 42-year-old woman with a giant splenic hemangioma, multiple hepatic hemangiomas and a history of oral estrogen intake for many years.
  • At first it was difficult to determine the organ from which the giant hemangioma originated.
  • Angiography proved extremely helpful in tracing its origin in the spleen.
  • Hematomas in the giant hemangioma posed a significant threat of rupture and catastrophic hemorrhage.
  • We left the small hepatic hemangiomas in place, and removed the spleen along with the giant splenic hemangioma.
  • CONCLUSION: Diagnostic pitfalls in the determination of the origin of this giant hemangioma, attribution of its origin to the spleen angiographically, the unusual co-existence of the giant splenic hemangioma with multiple hepatic ones, and the potential threat of rupture of the giant hemangioma are some of the highlights of this case report.
  • Splenectomy for the giant splenic hemangioma eliminates the risk of rupture and malignant degeneration, whereas observation for the small hepatic ones (<4 cm) was the preferable therapeutic strategy in our patient.

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  • (PMID = 18462497.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2394533
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2. Colović N, Cemerikić-Martinović V, Micev M, Radak V, Colović R: [Hemangioma of the spleen]. Srp Arh Celok Lek; 2006 Jul-Aug;134(7-8):325-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hemangioma of the spleen].
  • Although the most frequent benign tumors of the spleen, hemangiomas are very rare, much rarer than hemangiomas of the liver.
  • As the investigation showed a number of hypoechogenic lesions within the enlarged, diffusely non-homogenic spleen, splenectomy was indicated.
  • The spleen weighing 2600 grams was removed, in which the number of lesions histologically corresponded to hemangioma of the spleen.
  • [MeSH-major] Hemangioma
  • [MeSH-minor] Aged. Female. Humans. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 17009613.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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3. Ghuliani D, Agarwal S, Thomas S, Pathania OP: Giant cavernous haemangioma of the spleen presenting as massive splenomegaly and treated by partial splenectomy. Singapore Med J; 2008 Dec;49(12):e356-8
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  • [Title] Giant cavernous haemangioma of the spleen presenting as massive splenomegaly and treated by partial splenectomy.
  • Cavernous haemangioma is a rare disorder of the spleen with fewer than 100 cases reported.
  • Ultrasonography, Doppler studies, and computed tomography could not distinguish between a haemangioma and a secondary deposit.
  • Magnetic resonance imaging showed characteristic features of splenic haemangioma with central fibrosis, thrombosis and haemorrhage.
  • Histopathology showed cavernous haemangioma with areas of infarction necrosis.
  • It is extremely rare to have such a massive solitary splenic haemangioma presenting as a giant splenomegaly.
  • Preoperative investigations are often inconclusive and may not distinguish between haemangioma and metastases.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Splenectomy. Splenic Neoplasms / diagnosis. Splenomegaly / etiology

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  • (PMID = 19122934.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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4. Kaza RK, Azar S, Al-Hawary MM, Francis IR: Primary and secondary neoplasms of the spleen. Cancer Imaging; 2010;10:173-82
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  • [Title] Primary and secondary neoplasms of the spleen.
  • With the exception of lymphoma involving the spleen, other primary and secondary neoplasms are rare and infrequently encountered.
  • Primary malignant neoplasms involving the spleen are lymphoma and angiosarcoma.
  • Primary benign neoplasms involving the spleen include hemangioma, lymphangioma, littoral cell angioma and splenic cyst and solid lesions such as hamartoma and inflammatory pseudotumor.
  • [MeSH-major] Diagnostic Imaging. Splenic Diseases / diagnosis
  • [MeSH-minor] Cysts / diagnosis. Granuloma, Plasma Cell / diagnosis. Hamartoma / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Lymphangioma / diagnosis. Lymphoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology

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  • (PMID = 20713317.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 38
  • [Other-IDs] NLM/ PMC2943678
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5. Wang YJ, Li F, Cao F, Sun JB, Liu JF, Wang YH: Littoral cell angioma of the spleen. Asian J Surg; 2009 Jul;32(3):167-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral cell angioma of the spleen.
  • Littoral cell angioma (LCA) is a rare primary benign vascular neoplasm of the spleen.
  • Computed tomography (CT) and ultrasound (US) imaging studies showed multiple lesions in the spleen and gallbladder stones.

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  • (PMID = 19656757.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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6. Tee M, Vos P, Zetler P, Wiseman SM: Incidental littoral cell angioma of the spleen. World J Surg Oncol; 2008;6:87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental littoral cell angioma of the spleen.
  • BACKGROUND: Littoral cell angioma (LCA) is a recently described primary vascular neoplasm of the spleen that may be associated with other malignancies and may itself also have malignant potential.
  • Following this case presentation, clinical, radiographic, and pathological features of LCA will be reviewed as well as recent advances in our understanding of this uncommon splenic lesion.
  • CONCLUSION: LCA is a rare, generally benign, primary vascular tumour of the spleen that typically is discovered incidentally.
  • [MeSH-major] Hemangioma / diagnosis. Splenic Neoplasms / diagnosis
  • [MeSH-minor] Cholecystectomy. Colic / surgery. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18713469.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2527567
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7. Szpor J, Dyduch G: From hamartoma to splenic hemangioma. Pol J Pathol; 2008;59(1):33-41
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  • [Title] From hamartoma to splenic hemangioma.
  • Vascular benign lesions are the most common non-hematological splenic primary tumors.
  • Although rare they may sometimes pose problems in differential diagnosis, because of their morphologic heterogeneity.
  • We present vascular lesions of the spleen, which were found in archive of the Chair of Pathomorphology.
  • 8 benign vascular lesions were identified, including two hamartomas, two lesions representing sclerosing angiomatoid nodular transformation (SANT) and four hemangiomas.
  • We present briefly the spectrum of vascular lesions occurring in the spleen and discuss differential diagnosis and nosological status of selected lesions.
  • [MeSH-major] Hamartoma / diagnosis. Hemangioma / diagnosis. Splenic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 18655369.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Petroianu A, Teixeira BC, de Alencar LF: Partial splenectomy for treatment of splenic hemangioma. Chirurgia (Bucur); 2009 Jul-Aug;104(4):483-6
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  • [Title] Partial splenectomy for treatment of splenic hemangioma.
  • BACKGROUND: Although splenectomy is helpful in the management of splenic hemangioma, this procedure may result in a greater morbidity and even mortality, mainly caused by sepsis, when this operation is performed in children and teenagers, due to their immune deficiency.
  • In order to avoid the adverse effects associated with the asplenism, this paper proposes partial splenectomy is proposed to treat splenic hemangioma.
  • METHOD/CASE REPORT: A 13-year-old boy with hemangioma of the lower pole of the spleen was cared for by the authors.
  • Partial splenectomy of the lower third part of the spleen was carried out without bleeding or technical difficulties.
  • The over twenty five-month-follow-up showed normal spleen in size and functions without clinical adverse events.
  • CONCLUSION: Partial splenectomy should be considered and recommended as a good surgical treatment for splenic hemangioma.
  • [MeSH-major] Hemangioma / surgery. Splenectomy / methods. Splenic Neoplasms / surgery

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  • (PMID = 19886058.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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9. Lin CH, Yu JC, Shih ML, Peng YJ, Hsieh CB: Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma. J Formos Med Assoc; 2005 Apr;104(4):282-5
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  • [Title] Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma.
  • Littoral cell angioma (LCA) is a rare primitive vascular tumor of the spleen which is benign and usually associated with visceral malignancy.
  • The diagnosis of LCA is based on histologic and immunohistologic analysis.
  • Under the impression of hepatocellular carcinoma (HCC) and splenic tumor, partial hepatectomy and splenectomy were performed.
  • Histopathology showed a moderately differentiated HCC of the liver and splenic angioma with dilated vascular channels lined by plump endothelial cells.
  • Immunohistochemical staining of the splenic tumor showed focal positive reaction for factor VIII and CD68.
  • LCA of the spleen was diagnosed.

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  • (PMID = 15909068.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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10. Wang J, Pei G, Yan J, Zhang G: Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. J Pediatr Hematol Oncol; 2009 Dec;31(12):983-4
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  • [Title] Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer.
  • On the basis of computed tomography, ultrasound and epidemiology we preferred the diagnosis of a left adrenal neuroblastoma accompanied with multiple hepatic metastases preoperatively.
  • But postoperative diagnosis was hemangiomatosis characterized by synchronous presence of a giant splenic hemangioma and multiple hepatic hemangiomas.
  • We think that it is deservedly reported because of not only its rarity but also pitfalls of preoperative differential diagnosis and management principle.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neuroblastoma / diagnosis. Splenic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Ultrasonography


11. Ramdall RB, Alasio TM, Cai G, Yang GC: Primary vascular neoplasms unique to the spleen: littoral cell angioma and splenic hamartoma diagnosis by fine-needle aspiration biopsy. Diagn Cytopathol; 2007 Mar;35(3):137-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary vascular neoplasms unique to the spleen: littoral cell angioma and splenic hamartoma diagnosis by fine-needle aspiration biopsy.
  • We report the fine-needle aspiration (FNA) biopsy diagnosis of two rare cases of primary vascular neoplasms unique to the spleen: a littoral cell angioma from a 31-yr-old Caucasian woman and a splenic hamartoma from a 46-yr-old black man.
  • The cytologic features of splenic hamartoma and of littoral cell angioma of the spleen were described three times in cytologic literature: two were bench-top aspirates and one was FNA biopsy thought to be metastatic carcinoma.
  • Our approach to the FNA biopsy diagnosis of these rare vascular neoplasms via compact cell block and immunohistochemistry is described.
  • The differential diagnosis with other primary vascular splenic neoplasms is also discussed.
  • [MeSH-major] Hamartoma / diagnosis. Hamartoma / pathology. Hemangioma / diagnosis. Hemangioma / pathology. Spleen / pathology. Splenic Diseases / diagnosis. Vascular Neoplasms / pathology

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  • (PMID = 17304535.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Tatli S, Cizginer S, Wieczorek TJ, Ashley SW, Silverman SG: Solitary littoral cell angioma of the spleen: computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr; 2008 Sep-Oct;32(5):772-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary littoral cell angioma of the spleen: computed tomography and magnetic resonance imaging features.
  • Littoral cell angioma is a rare primary vascular neoplasm of the spleen composed of blood-filled vascular channels.
  • Typically, littoral cell angioma presents with splenomegaly caused by multiple small hypoattenuating nodules that show delayed enhancement.
  • We report an unusual case of littoral cell angioma of the spleen that presented as a large solitary mass.
  • [MeSH-major] Hemangioma / diagnosis. Magnetic Resonance Imaging. Splenic Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 18830109.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Priego P, Rodríguez Velasco G, Griffith PS, Fresneda V: Littoral cell angioma of the spleen. Clin Transl Oncol; 2008 Jan;10(1):61-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral cell angioma of the spleen.
  • Littoral cell angiomas (LCAs) are rare splenic vascular neoplasms that arise from the cells lining the red pulp sinuses.
  • The clinical course is benign and in most cases asymptomatic.
  • The definitive diagnosis is made on histology and confirmed with immunohistochemistry.
  • The use of percutaneous fine-needle aspiration biopsy (FNA) in preoperative diagnosis is controversial.
  • [MeSH-major] Hemangioma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18208795.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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14. Bi CF, Jiang LL, Li Z, Liu WP: [Littoral cell angioma of spleen: a clinicopathologic study of 17 cases]. Zhonghua Bing Li Xue Za Zhi; 2007 Apr;36(4):239-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Littoral cell angioma of spleen: a clinicopathologic study of 17 cases].
  • OBJECTIVE: To study the clinicopathologic features and immunophenotype of splenic littoral cell angioma.
  • METHODS: The clinical features, radiologic findings and histopathology of 17 cases of splenic littoral cell angioma were retrospectively reviewed.
  • Immunohistochemical study was carried out on paraffin-embedded tissues, using normal spleen, cases of congestive splenomegaly and cavernous hemangioma as controls.
  • Gross examination revealed enlarged spleen containing single or multiple tan-colored nodules which ranged from 0.2 cm to 6.0 cm in diameter.
  • The immunophenotype of splenic littoral cell angioma was different from that of the controls.
  • CONCLUSIONS: Littoral cell angioma is a benign condition, likely secondary to hemodynamic disturbance in spleen.
  • The littoral cells become hyperplastic and anastomose, resulting in a hemangioma-like growth associated with histiocytic reaction.
  • Attention to the characteristic histopathologic findings and immunophenotype are crucial for diagnosis.
  • [MeSH-major] Antigens, CD31 / metabolism. Hemangioma / pathology. Spleen / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Hemangioma, Cavernous / immunology. Hemangioma, Cavernous / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Receptors, Cell Surface / metabolism. Retrospective Studies. Splenomegaly / metabolism. Splenomegaly / pathology. von Willebrand Factor / metabolism

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  • (PMID = 17706114.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD163 antigen; 0 / CD68 antigen, human; 0 / Receptors, Cell Surface; 0 / von Willebrand Factor
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15. Qu ZB, Liu LX, Wu LF, Zhao S, Jiang HC: Multiple littoral cell angioma of the spleen: a case report and review of the literature. Onkologie; 2007 May;30(5):256-8
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  • [Title] Multiple littoral cell angioma of the spleen: a case report and review of the literature.
  • BACKGROUND: Littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen with characteristic histomorphologic features.
  • It is a unique splenic tumor which may present with abdominal pain or as an incidental finding.
  • CASE REPORT: In this case report, we present the case of a 34-year-old woman with multiple splenic LCA.
  • After a diagnostic abdominal ultrasound, multiple hemangiomas were observed in the spleen.
  • Postoperative histological and immunohistochemical profiles confirmed the diagnosis of LCA.
  • CONCLUSION: LCA is a unique splenic tumor diagnosed in patients with abdominal pain or as an incidental finding.
  • [MeSH-major] Hemangioma / surgery. Neoplasms, Multiple Primary / surgery. Splenic Neoplasms / surgery
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Female. Humans. Spleen / pathology. Splenectomy. Tomography, X-Ray Computed

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  • (PMID = 17460421.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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16. Cosme A, Tejada A, Bujanda L, Vaquero M, Elorza JL, Ojeda E, Goikoetxea U: Littoral-cell angioma of the spleen: a case report. World J Gastroenterol; 2007 Dec 28;13(48):6603-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral-cell angioma of the spleen: a case report.
  • Littoral-cell angioma (LCA) is a primary splenic vascular tumor that arises from the normal littoral cells lining the sinus channels of the splenic red pulp.
  • We report a case of LCA of the spleen, which has been infrequently communicated in the literature.
  • Imaging studies (CT and MRI) showed multiple lesions in the spleen.
  • LCA is a benign vascular tumor of the spleen that needs to be included in the differential diagnosis of multiple splenic nodules.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / pathology. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / metabolism. Antigens, CD31 / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Biomarkers / metabolism. Humans. Male. Spleen / metabolism. Spleen / pathology. Spleen / surgery. Splenectomy

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  • (PMID = 18161935.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers; 0 / CD68 antigen, human
  • [Other-IDs] NLM/ PMC4611304
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17. Yamate J, Izawa T, Kuwamura M, Mitsunaga F, Nakamura S: Vasoformative disorder, resembling littoral cell angioma, of the spleen in a geriatric Japanese macaque (Macaca fuscata). Vet Pathol; 2009 May;46(3):520-5
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  • [Title] Vasoformative disorder, resembling littoral cell angioma, of the spleen in a geriatric Japanese macaque (Macaca fuscata).
  • The enlarged spleen consisted of neoplastic proliferation of anastomosing vascular channels resembling morphologic structures of red pulp sinuses; occasionally, papillary fronds were seen in dilated channels.
  • Immunohistochemically, the lining cells reacted to both endothelial cell (von Willebrand factor) and macrophage (macrophage scavenger receptor class A) markers, indicating features of littoral cells of the spleen.
  • Based on the pathologic characteristics, particularly the presence of neoplastic cells with macrophage/histiocyte-like attributes, this tumor was regarded as littoral cell angioma; this is a rare benign splenic vascular tumor.
  • [MeSH-major] Hemangioma / veterinary. Macaca. Monkey Diseases / pathology. Splenic Neoplasms / veterinary
  • [MeSH-minor] Aging. Animals. Female. Spleen / pathology

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  • (PMID = 19176500.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Mühlfeld AS, Eitner F, Perez-Bouza A, Knuechel R, Heintz B, Floege J: Littoral cell angioma of the spleen mimicking posttransplantation lymphoma in a 63-year-old renal transplant patient. Am J Kidney Dis; 2008 Sep;52(3):e11-4
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  • [Title] Littoral cell angioma of the spleen mimicking posttransplantation lymphoma in a 63-year-old renal transplant patient.
  • In addition to lymphomas, vascular tumors represent the most common neoplasms of the spleen.
  • Littoral cell angiomas are benign vascular tumors originating from the littoral cells lining the splenic sinuses.
  • Diagnostic workup showed multiple splenic masses believed to represent lymphoma infiltration to the spleen.
  • Histological examination of the pathological specimen from the splenectomy specimen showed multiple littoral cell angiomas of the spleen.
  • We recommend that physicians involved in the area of organ transplantation, especially kidneys, remain alert for other rarer splenic lesions in transplant recipients than posttransplantation lymphoma.
  • More specific tools need to be developed to aid in the differential diagnosis of splenic masses to avoid splenectomy in patients with littoral cell angiomas.
  • [MeSH-major] Hemangioma / diagnosis. Kidney Transplantation / adverse effects. Lymphoma / diagnosis. Lymphoma / etiology. Neoplasms, Second Primary / diagnosis. Splenic Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Spleen / pathology. Spleen / radiography. Tomography, X-Ray Computed

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  • (PMID = 18479795.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Altomare I, Desman G, Aledort LM: Echinocytosis--an unusual manifestation of hemangioma. Am J Hematol; 2006 Jul;81(7):532-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Echinocytosis--an unusual manifestation of hemangioma.
  • The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported.
  • A CT-recognized splenic mass led to splenectomy and a benign hemangioma was found.
  • This is the first case reported in the literature of echinocytosis as a consequence of a hemangioma.
  • [MeSH-major] Erythrocytes, Abnormal. Hemangioma / pathology. Spleen / pathology. Splenic Neoplasms / pathology

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  • (PMID = 16755560.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. von Herbay A, Barreiros AP, Ignee A, Westendorff J, Gregor M, Galle PR, Dietrich C: Contrast-enhanced ultrasonography with SonoVue: differentiation between benign and malignant lesions of the spleen. J Ultrasound Med; 2009 Apr;28(4):421-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast-enhanced ultrasonography with SonoVue: differentiation between benign and malignant lesions of the spleen.
  • OBJECTIVE: We investigated the ability of contrast-enhanced ultrasonography with SonoVue (Bracco SpA, Milan, Italy), a sulfur hexafluoride microbubble contrast agent, to reveal differences between benign and malignant focal splenic lesions.
  • METHODS: In a prospective study we investigated 35 lesions in 35 patients (24 male and 11 female; mean age +/- SD, 54 +/- 15 years) with focal splenic lesions detected by B-mode ultrasonography.
  • After intravenous injection of 1.2 to 2.4 mL of SonoVue, the spleen was examined continuously for 3 minutes using low-mechanical index ultrasonography with contrast-specific software.
  • The final diagnosis was established by histologic examination, computed tomography, or magnetic resonance imaging.
  • RESULTS: In 14 patients, the splenic lesions were malignant (metastasis, n = 6; non-Hodgkin lymphoma, n = 6; and Hodgkin lymphoma, n = 2).
  • In 21 patients, the focal splenic lesions were benign (ischemic lesion, n = 6; echogenic cyst, n = 5; abscess, n = 4; hemangioma, n = 3; hematoma, n = 1; hemophagocytosis syndrome, n = 1; and splenoma, n = 1.
  • Typical findings for benign lesions were 2 arrival patterns: no contrast enhancement (neither in the early nor in the parenchymal phase; P < .05) and the beginning of contrast enhancement in the early phase followed by contrast enhancement in the parenchymal phase 60 seconds after injection.
  • CONCLUSIONS: Contrast-enhanced ultrasonography is helpful in the differentiation between benign and malignant lesions of the spleen.
  • [MeSH-major] Image Enhancement / methods. Lymphoma / ultrasonography. Phospholipids. Splenic Neoplasms / ultrasonography. Sulfur Hexafluoride

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  • (PMID = 19321670.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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21. Pang WB, Zhang TC, Chen YJ, Zhang JZ: Space-occupying benign lesions in spleen: experiences in a single institute. Pediatr Surg Int; 2009 Jan;25(1):31-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Space-occupying benign lesions in spleen: experiences in a single institute.
  • PURPOSE: To introduce a practical reference for the diagnosis and treatment of space-occupying benign lesions in children's spleens.
  • METHOD: Ten cases were collected from 1988 to 2007, and analysis of some related literature were included with special attention to the criteria of the diagnosis and the indications of splenectomy, particularly to the age for operation.
  • The clinical diagnosis depended on ultrasonographic or other imaging findings, while the final diagnosis was based on pathological study of operative specimens.
  • The final diagnosis of the five patients undergoing operation was benign tumors (angioma group), and the other five were cystic (mainly congenital).
  • CONCLUSION: Preoperative imaging examinations and postoperative pathology mutually confirmed space-occupying benign lesions in the spleen.
  • [MeSH-major] Cysts / diagnosis. Cysts / surgery. Hemangioma / diagnosis. Hemangioma / surgery. Splenic Diseases / diagnosis. Splenic Diseases / surgery

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  • (PMID = 18956203.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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22. Blansfield JA, Goldhahn RT Jr, Josloff RK: Littoral cell angioma of the spleen treated by laparoscopic splenectomy. JSLS; 2005 Apr-Jun;9(2):222-4
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  • [Title] Littoral cell angioma of the spleen treated by laparoscopic splenectomy.
  • Massive splenomegaly due to multifocal littoral cell angioma was discovered incidentally in a 55-year-old man during a workup for an unrelated condition.
  • We report the second case of littoral cell angioma of the spleen treated laparoscopically.

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  • [Cites] AJR Am J Roentgenol. 2000 Feb;174(2):467-9 [10658726.001]
  • [Cites] Histopathology. 2001 Nov;39(5):469-75 [11737304.001]
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  • (PMID = 15984716.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3015579
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23. Hartmann M, Marx A, Geissinger E, Müller-Hermelink HK, Rüdiger T: [Vascular proliferations of the spleen]. Pathologe; 2008 Mar;29(2):129-35
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  • [Title] [Vascular proliferations of the spleen].
  • [Transliterated title] Vaskuläre Tumoren der Milz.
  • Vascular proliferations of the spleen reflect the variability of vascular structures occurring in the normal spleen.
  • Besides haemangiomas, there is a spleen-specific vascular neoplasm, littoral cell angioma, that often occurs as a paraneoplastic lesion and thus may require the differential diagnostic delineation of metastases to the spleen in patients with known neoplasms.
  • The most common malignant vascular tumours of the spleen are angiosarcomas.
  • A recently described vascular lesion of unknown pathogenesis, sclerosing angiomatoid nodular transformation (SANT) of the spleen, usually is an incidental finding detected in the course of imaging studies.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Spleen / blood supply. Splenic Neoplasms / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Hamartoma / pathology. Histiocytoma, Benign Fibrous / pathology. Humans. Lymphangioma / pathology. Paraneoplastic Syndromes / pathology. Vascular Diseases / pathology

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  • (PMID = 18214485.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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24. Pachl M, Elmalik K, Cohen M, Kamupira S, Walker J, Murthi G: Ruptured splenic cavernous hemangioma in a neonate. J Pediatr Surg; 2008 Feb;43(2):407-9
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  • [Title] Ruptured splenic cavernous hemangioma in a neonate.
  • An ultrasound scan at 48 hours after birth followed by a computed tomographic scan demonstrated a splenic lesion and hemoperitoneum.
  • She underwent an emergency laparotomy and splenectomy for splenic rupture.
  • Histologic findings demonstrated a ruptured cavernous hemangioma of the spleen.
  • The diagnosis and management, with particular reference to splenic cavernous hemangioma and splenic rupture, is discussed.
  • [MeSH-major] Hemangioma, Cavernous / surgery. Splenic Neoplasms / surgery. Splenic Rupture / surgery
  • [MeSH-minor] Female. Follow-Up Studies. Hemoperitoneum / diagnosis. Hemoperitoneum / surgery. Humans. Immunohistochemistry. Infant, Newborn. Laparotomy. Risk Assessment. Shock / diagnosis. Shock / etiology. Splenectomy / methods. Term Birth. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18280302.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Awamleh AA, Perez-Ordoñez B: Sclerosing angiomatoid nodular transformation of the spleen. Arch Pathol Lab Med; 2007 Jun;131(6):974-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing angiomatoid nodular transformation of the spleen.
  • Sclerosing angiomatoid nodular transformation (SANT) is a recently recognized nonneoplastic vascular lesion of the spleen with fewer than 30 cases described.
  • The vascular nodules display a complex mixture of endothelial phenotypes resembling splenic sinusoids (CD34-/CD31+/CD8+), capillaries (CD34+/ CD31+/CD8-), and small veins (CD34-/CD31+/CD8-).
  • The differential diagnosis of SANT includes splenic hamartoma, inflammatory myofibroblastic tumor, littoral cell angioma, and hemangioendothelioma.
  • It has been postulated that SANT represents a peculiar hamartomatous transformation of splenic red pulp in response to an exaggerated nonneoplastic stromal proliferation.
  • SANT has a benign clinical course with splenectomy being curative.
  • [MeSH-major] Angiomatosis / pathology. Spleen / pathology. Splenic Diseases / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Biomarkers / metabolism. Diagnosis, Differential. Female. Hamartoma / diagnosis. Hemangioendothelioma / diagnosis. Hemangioma / diagnosis. Humans. Middle Aged. Myofibroma / diagnosis. Treatment Outcome

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  • (PMID = 17550330.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers
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26. Görg C, Görg K, Bert T, Barth P: Colour Doppler ultrasound patterns and clinical follow-up of incidentally found hypoechoic, vascular tumours of the spleen: evidence for a benign tumour. Br J Radiol; 2006 Apr;79(940):319-25
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  • [Title] Colour Doppler ultrasound patterns and clinical follow-up of incidentally found hypoechoic, vascular tumours of the spleen: evidence for a benign tumour.
  • Between January 1990 and January 2005, incidental hypoechoic, vascular tumours of the spleen were identified in 13 patients using B-mode and colour Doppler ultrasound (CDS).
  • Histological examination was performed in three patients with the diagnosis of capillary haemangioma (n = 2) and hamartoma (n = 1).
  • In the spleen a hypoechoic lesion with an increased vascular pattern incidentally found by ultrasound most likely indicates a benign tumour with capillary haemangioma/hamartoma as the most likely diagnosis.
  • [MeSH-major] Incidental Findings. Spleen / ultrasonography. Splenic Diseases / ultrasonography. Ultrasonography, Doppler, Color. Ultrasonography, Interventional
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Hamartoma / blood supply. Hamartoma / ultrasonography. Hemangioma, Capillary / blood supply. Hemangioma, Capillary / ultrasonography. Humans. Male. Middle Aged

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  • (PMID = 16585725.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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27. Teng XD, Yu XR, Wang GH, Xu LJ, Lai MD: [Sclerosing angiomatoid nodular transformation of spleen]. Zhonghua Bing Li Xue Za Zhi; 2007 Feb;36(2):118-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing angiomatoid nodular transformation of spleen].
  • OBJECTIVE: To study the clinicopathologic features of sclerosing angiomatoid nodular transformation of spleen and its differential diagnosis.
  • METHODS: The clinicopathologic characteristics and immunophenotype of 4 cases of sclerosing angiomatoid nodular transformation of spleen were studied.
  • CONCLUSIONS: Sclerosing angiomatoid nodular transformation is a rarely encountered benign lesion of the spleen, which should be distinguished from other angiomatoid tumors and tumor-like lesions.
  • [MeSH-major] Angiomatosis / pathology. Spleen / pathology. Splenic Diseases / pathology
  • [MeSH-minor] Adult. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Antigens, CD8 / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Hamartoma / pathology. Hemangioma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Sclerosis / pathology. Splenectomy. Splenic Neoplasms / pathology

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  • (PMID = 17493387.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Antigens, CD8
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28. Hou J, Ji Y, Tan YS, Shi DR, Liu YL, Xu C, Zeng HY: [Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic study of 10 cases with review of literature]. Zhonghua Bing Li Xue Za Zhi; 2010 Feb;39(2):84-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic study of 10 cases with review of literature].
  • OBJECTIVE: To study the clinicopathologic features, differential diagnosis and pathogenesis of sclerosing angiomatoid nodular transformation of spleen.
  • METHODS: Ten cases of sclerosing angiomatoid nodular transformation of spleen were retrieved from the archival file.
  • CONCLUSIONS: Sclerosing angiomatoid nodular transformation of spleen is a rare benign entity.
  • It may represent a reactive condition and bears some relationship with splenic angioma.
  • It needs to be distinguished from borderline or malignant vascular tumors of spleen.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Antigens, CD8 / metabolism. Diagnosis, Differential. Female. Hemangioendothelioma / metabolism. Hemangioendothelioma / pathology. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Male. Microscopy, Electron. Middle Aged

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  • (PMID = 20388372.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Antigens, CD8
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29. Elsayes KM, Narra VR, Mukundan G, Lewis JS Jr, Menias CO, Heiken JP: MR imaging of the spleen: spectrum of abnormalities. Radiographics; 2005 Jul-Aug;25(4):967-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR imaging of the spleen: spectrum of abnormalities.
  • The spleen has the same relationship to the circulatory system that the lymph nodes have to the lymphatic system.
  • A wide range of diseases can affect the spleen.
  • Pathologic conditions of the spleen can be classified into the following categories: congenital diseases (accessory spleen, polysplenia, and asplenia); trauma; inflammation (abscess, candidiasis, histoplasmosis, and sarcoidosis); vascular disorders (infarction, diseases affecting the splenic vasculature, and arteriovenous malformation); hematologic disorders (sickle cell disease and extramedullary hematopoiesis); benign tumors (cysts, hemangioma, diffuse hemangiomatosis of the spleen, and hamartoma); malignant tumors (sarcoma, lymphoma, and metastases); and other disease processes that affect the spleen diffusely (portal hypertension, Gaucher disease, and sickle cell disease) or focally (Gamna-Gandy nodules).
  • New magnetic resonance (MR) imaging techniques have increased the role of MR imaging in detection and characterization of splenic diseases.
  • MR imaging is an excellent tool for diagnosis and evaluation of focal lesions and pathologic conditions of the spleen.
  • [MeSH-major] Magnetic Resonance Imaging. Splenic Diseases / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 16009818.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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30. Quirós JL, Manes L, Bonandini E, Vivaldi P, Dalla Palma P, Barbareschi M: Sclerosing angiomatoid nodular transformation of the spleen associated with thrombocytopenia. Pathologica; 2010 Apr;102(2):67-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing angiomatoid nodular transformation of the spleen associated with thrombocytopenia.
  • Sclerosing angiomatoid nodular transformation of the spleen, a recently described lesion of unknown pathogenesis, with a benign clinical course that is very often asymptomatic.
  • Sclerosing angiomatoid nodular transformation may be a novo lesion or the final common pathway of various benign splenic conditions such as hamartoma, inflammatory pseudotumor and hemangioma.
  • We report the case of a 68 year-old woman with thrombocytopenia and a splenic mass, diagnosed as sclerosing angiomatoid nodular transformation.
  • [MeSH-major] Splenic Neoplasms / complications. Splenic Neoplasms / pathology. Thrombocytopenia / complications

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  • (PMID = 23596760.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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31. El Demellawy D, Nasr A, Alowami S: Sclerosing angiomatoid nodular transformation of the spleen: case report. Pathol Res Pract; 2009;205(4):289-93
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  • [Title] Sclerosing angiomatoid nodular transformation of the spleen: case report.
  • Sclerosing angiomatoid transformation of the spleen (SANT) is a relatively new, rare, and unique lesion that involves the spleen.
  • The lesion is entirely benign, and splenectomy is curative.
  • We report a new case of SANT, with emphasis on the differential diagnosis and pathogenesis of SANT.
  • [MeSH-major] Hemangioma / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Non-Small-Cell Lung / complications. Female. Histiocytes / pathology. Humans. Immunohistochemistry. Lung Neoplasms / complications. Middle Aged. Spleen / blood supply. Spleen / pathology. Splenectomy

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  • (PMID = 19171438.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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32. Koreishi AF, Saenz AJ, Fleming SE, Teruya-Feldstein J: Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a report of 3 cases. Int J Surg Pathol; 2009 Oct;17(5):384-9
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  • [Title] Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a report of 3 cases.
  • The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009).
  • Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature.
  • [MeSH-major] Hemangioma / pathology. Spleen / blood supply. Splenic Neoplasms / pathology

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  • (PMID = 19666947.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Immunoglobulin G
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33. Dazé Y, Gosselin J, Bernier V: [Sclerosing angiomatoid nodular transformation of the spleen (SANT): a case report]. Ann Pathol; 2008 Sep;28(4):321-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing angiomatoid nodular transformation of the spleen (SANT): a case report].
  • [Transliterated title] Transformation angiomatoïde nodulaire sclérosante de la rate (TANS): présentation d'un cas.
  • We report a case of sclerosing angiomatoid nodular transformation of the spleen incidently discovered in a 41-year-old man.
  • The immunohistochemical markers carried out showed the presence of capillaries, veins and sinusoids normally found within the splenic parenchyma, but adopting an unusual configuration.
  • This distinct entity, recently described and completely benign, must be included in the differential diagnosis of the vascular lesions of the spleen, which includes, among others, the hemangioma, the littoral cell angioma, the hemangioendothelioma and the inflammatory myofibroblastic tumor.
  • [MeSH-major] Hemangioendothelioma / pathology. Spleen / pathology. Splenic Diseases / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18928875.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD; 9007-34-5 / Collagen
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34. Görg C: The forgotten organ: contrast enhanced sonography of the spleen. Eur J Radiol; 2007 Nov;64(2):189-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The forgotten organ: contrast enhanced sonography of the spleen.
  • Contrast enhanced sonography (CES) of second-generation contrast media have shown a spleen-specific uptake of the microbubble contrast agent.
  • The aim of this review is to illustrate indications for the use of CES in patients with suspected (peri-)splenic pathology.
  • METHODS: This review based on the experience of transcutaneous CES in 200 patients with (peri-)splenic pathology diagnosed by B-mode sonography at an internal medicine center.
  • (1) the perisplenic tumor to diagnose or exclude accessory spleen, (2) the small-sized spleen to diagnose functional asplenia/hyposplenia, (3) the inhomogenous spleen of unknown cause to diagnose focal lesions within the spleen, (4) the incidentally found hypoechoic splenic tumor to diagnose high vascular splenic hemangioma, (5) focal lesions suspect for splenic abscess, hematoma, infarction to confirme diagnosis, and (6) patients with abdominal trauma to diagnose or exclude splenic injury.
  • CONCLUSION: CES is of diagnostic value in several clinical circumstances to diagnose accessory spleen, functional asplenia, small-sized splenic involvement, high vascular splenic hemangioma, and vascular splenic pathology like splenic infarction, splenic abscess, and splenic laceration.
  • [MeSH-major] Contrast Media. Image Enhancement / methods. Spleen / ultrasonography. Splenic Diseases / ultrasonography
  • [MeSH-minor] Humans. Microbubbles. Phospholipids. Splenic Neoplasms / ultrasonography. Sulfur Hexafluoride

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  • (PMID = 17920224.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
  • [Number-of-references] 52
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35. Santoro L, Santini V, Lollo SD, Valeri A, Colagrande S: Hemolymphangiomatosis of the spleen: imaging features. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):831-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemolymphangiomatosis of the spleen: imaging features.
  • Ultrasonography (US), basal MR imaging, and late computed tomography (CT) contrastographic features are quite similar to those of other diffuse benign vascular neoplasms, without real hemangioma-like enhancement during the vascular phase.
  • [MeSH-major] Lymphangioleiomyomatosis / diagnosis. Spleen / pathology. Spleen / radiography. Splenic Neoplasms / diagnosis

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  • (PMID = 16272860.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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36. Suvajdzić N, Cemerikić-Martinović V, Saranović D, Petrović M, Popović M, Artiko V, Cupić M, Elezović I: Littoral-cell angioma as a rare cause of splenomegaly. Clin Lab Haematol; 2006 Oct;28(5):317-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral-cell angioma as a rare cause of splenomegaly.
  • We report the case of a littoral-cell angioma of the spleen, a recently described benign vascular tumour, whose imaging and pathological characteristics have been discussed only by a few authors.
  • The diagnosis was made after elective splenectomy.
  • [MeSH-major] Hemangioma / complications. Splenic Neoplasms / complications. Splenomegaly / etiology

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  • (PMID = 16999722.001).
  • [ISSN] 0141-9854
  • [Journal-full-title] Clinical and laboratory haematology
  • [ISO-abbreviation] Clin Lab Haematol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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37. Islam S, Newman EA, Strouse PJ, Geiger JD: Antiangiogenic therapy for a large splenic hemangioma. Pediatr Surg Int; 2005 Dec;21(12):1007-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antiangiogenic therapy for a large splenic hemangioma.
  • Hemangiomas involving the spleen are rare and seldom symptomatic.
  • We report our experience of successfully using glucocorticoids in an infant with a large hemangioma of the spleen.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Glucocorticoids / therapeutic use. Hemangioma / drug therapy. Prednisone / therapeutic use. Splenic Neoplasms / drug therapy

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  • (PMID = 16215767.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Glucocorticoids; VB0R961HZT / Prednisone
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38. Happel B, Niederle B, Puespoek A, Ba-Ssalamah A, Schima W: [Benign neuroendocrine and other rare benign tumors of the pancreas]. Radiologe; 2008 Aug;48(8):752-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign neuroendocrine and other rare benign tumors of the pancreas].
  • Very rare entities are the schwannoma, leiomyoma, teratoma, intrapancreatic lipoma, hemangioma and the intrapancreatic accessory spleen.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Neuroendocrine Tumors / diagnosis. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed / methods. Ultrasonography / methods
  • [MeSH-minor] Humans. Rare Diseases / diagnosis

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  • (PMID = 18633589.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 41
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39. Hansen T, Habekost M, Flieger D, Kirkpatrick CJ: [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]. Pathologe; 2010 Jul;31(4):290-2
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  • [Title] [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma].
  • [Transliterated title] Littoralzellangiom der Milz. Assoziation mit Kolon- und hepatozellulärem Karzinom.
  • Littoral cell angioma is a rare vascular tumor of the spleen.
  • We report the case of a 67-year-old man suffering from colon carcinoma and presenting with a tumor of the spleen which could be seen using radiography.
  • Due to the relationship with malignant tumors littoral cell angioma should be considered in every case of a splenic tumoral space-occupying mass, particularly in carcinoma patients.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Hepatocellular / pathology. Colonic Neoplasms / pathology. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / analysis. Antigens, CD31 / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Colectomy. Colon / pathology. Hepatectomy. Humans. Liver / pathology. Male. Neoplasm Staging. Spleen / pathology. Splenectomy

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  • (PMID = 20349061.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human
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40. Ertan G, Tekes A, Mitchell S, Keefer J, Huisman TA: Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging. Pediatr Radiol; 2009 Oct;39(10):1105-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric littoral cell angioma of the spleen: multimodality imaging including diffusion-weighted imaging.
  • Littoral cell angioma (LCA) is a rare primary splenic vascular tumor originating from littoral cells lining the splenic red pulp sinuses.
  • The current case indicates that increased ADC values within the splenic lesions suggest a vascular etiology, which might help narrow the differential diagnosis.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Hemangioma / diagnosis. Splenic Neoplasms / diagnosis. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 19597808.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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41. Tang JY, Chen J, Pan C, Yin MZ, Zhu M: Diffuse cavernous hemangioma of the spleen with Kasabach-Merritt syndrome misdiagnosed as idiopathic thrombocytopenia in a child. World J Pediatr; 2008 Aug;4(3):227-30
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  • [Title] Diffuse cavernous hemangioma of the spleen with Kasabach-Merritt syndrome misdiagnosed as idiopathic thrombocytopenia in a child.
  • BACKGROUND: Most cavernous hemangiomas in the spleen are small lesions that are found incidentally and patients usually present with no symptoms.
  • But some patients with diffuse cavernous hemangioma may present with anemia, thrombocytopenia, coagulopathy and bleeding, which might be misdiagnosed as idiopathic thrombocytopenia with disseminated intravascular coagulation (DIC).
  • METHODS: The history, imaging results, pathologic findings, diagnosis and treatment of a 34-month-old boy with severe petechiae were reviewed.
  • Diffuse cavernous hemangioma of the spleen was highly suspected, but it was not confirmed by B ultrasound, enhanced CT or MRI.
  • A diffuse cavernous hemangioma involving the whole spleen was confirmed pathologically following a successful splenectomy.
  • CONCLUSIONS: Diffuse cavernous hemangioma of the spleen should be differentiated from ITP associated with splenomegaly.
  • [MeSH-major] Blood Coagulation Disorders / diagnosis. Hemangioma, Cavernous / diagnosis. Splenic Neoplasms / diagnosis. Thrombocytopenia / diagnosis
  • [MeSH-minor] Child, Preschool. Disseminated Intravascular Coagulation / diagnosis. Humans. Magnetic Resonance Imaging. Male. Splenectomy. Syndrome. Tomography, X-Ray Computed


42. Rana N, Ming Z, Hui MS, Bin Y: Case Report: Littoral cell angioma of spleen. Indian J Radiol Imaging; 2009 Jul-Sep;19(3):210-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case Report: Littoral cell angioma of spleen.
  • Littoral cell angioma is a rare primary vascular neoplasm of the spleen, composed of littoral cells that line the splenic sinuses of the red pulp.
  • It was thought to be a benign, incidental lesion.
  • The definitive diagnosis can only be made after histology and immunohistochemistry studies.

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  • [Cites] Clin Transl Oncol. 2008 Jan;10(1):61-3 [18208795.001]
  • [Cites] World J Gastroenterol. 2007 Dec 28;13(48):6603-4 [18161935.001]
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  • (PMID = 19881088.001).
  • [ISSN] 1998-3808
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2766879
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43. Berman E, Ikpatt F, Wang D, Dembner A, Zauber NP: Rapid progression of littoral cell angioma of the spleen in a man with multiple infections. Rare Tumors; 2010;2(1):e17

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid progression of littoral cell angioma of the spleen in a man with multiple infections.
  • Littoral cell angioma is an uncommon primary vascular neoplasm of the spleen.
  • It frequently follows a benign course, but cases with aggressive behavior have been described.
  • We present a case of this rare disease highlighting radiological examinations showing a rapid increase in the size of the spleen as well as an increase in the number and size of existing nodules.
  • We also discuss the relationship of this disorder to chronic infections and its possible association with Epstein Barr virus.

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  • (PMID = 21139945.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994494
  • [Keywords] NOTNLM ; infections / littoral cell angioma / spleen
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44. Erçin C, Gürbüz Y, Hacihanefioğlu A, Turgut Karakaya A: Multiple littoral cell angioma of the spleen in a case of myelodysplastic syndrome. Hematology; 2005 Apr;10(2):141-4
MedlinePlus Health Information. consumer health - Myelodysplastic Syndromes.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple littoral cell angioma of the spleen in a case of myelodysplastic syndrome.
  • Littoral cell angioma (LCA) of the spleen is a relatively recently described rare entity, which is associated with haemophagocytosis.
  • In this case report, we will present a case of myelodysplastic syndrome with multiple LCA of the spleen.
  • The patient presented with pancytopenia and multiple haemangiomas were observed in spleen during diagnostic abdominal ultrasound.
  • As LCA of the spleen and myelodysplastic syndrome may both cause cytopenia their co-existence may complicate the clinical presentation leading to an incomplete or inappropriate diagnosis.
  • In cases of haematological disorders with an atypical course, the radiological examination of the spleen should be considered and the possibility of angiomas must be included to the differential diagnosis.
  • [MeSH-major] Hemangioma / pathology. Myelodysplastic Syndromes / pathology. Splenic Neoplasms / pathology

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  • (PMID = 16019460.001).
  • [ISSN] 1024-5332
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Wang J, Xie SD, Luo L, Zhang JS, Liu LY, Xu C, Jiang ZB, Yang Y, Zhang YQ, Kuang SC, Hu B, Shan H: [Low dose contrast-enhanced 4D DSA with the 320-detector row computed tomography scanner for post-operative evaluation of the hepatic artery complications after liver transplantation]. Zhonghua Yi Xue Za Zhi; 2010 Jan 19;90(3):165-8
MedlinePlus Health Information. consumer health - Liver Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To evaluate the value of low-dose contrast-enhanced 4D DSA acquired from 320-detector row CT on the diagnosis of the hepatic artery complications after liver transplantation.
  • METHODS: 320-detector row CT were performed in fifth patients with liver dynamic enhanced using volume CT body-perfusion protocol, hepatic artery phase images obtained after intravenous injection of 50 ml of contrast at a rate of 6 ml/s were acquired based on 4D DSA.
  • 4D DSA also displayed other signs including hepatic hemangioma and the splenic artery aneurysms (SAA) and ectasi (n = 1), donor-recipient hepatic artery mismatch (n = 3).
  • CONCLUSION: 4D DSA provided a safe, noninvasive and accurate method for guiding the diagnosis of hepatic artery complication and play an effective role after liver transplantation.

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  • (PMID = 20356550.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Contrast Media
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46. Tetreau R, Beziat C, Marion D, Gouillat C, Lapras V, Bancel B: [Capillary hemangioma of the spleen on conventional and contrast-enhanced US]. J Radiol; 2006 May;87(5):575-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Capillary hemangioma of the spleen on conventional and contrast-enhanced US].
  • [Transliterated title] Hémangiome capillaire splénique en échographie conventionnelle et avec produit de contraste.
  • We report a case of splenic vascular neoplasm in a 75 year old asymptomatic woman.
  • CT and enhanced sonography were not consistent with a typical hemangioma.
  • Splenectomy was finally realised and pathologic exam showed a capillary hemangioma with thrombosis.
  • The imaging appearance of splenic hemangiomas may be complex because of splenic topography, size and complicating features.
  • [MeSH-major] Hemangioma, Capillary / ultrasonography. Splenic Neoplasms / ultrasonography

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  • (PMID = 16733417.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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47. Ali TZ, Beyer G, Taylor M, Volpe C, Papadimitriou JC: Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases. Int J Surg Pathol; 2005 Jan;13(1):103-11
MedlinePlus Health Information. consumer health - Spleen Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases.
  • Splenic hamartoma (SH) is a rare, benign lesion.
  • Immunohistochemical staining with factor VIII displayed intense diffuse staining in the SH with corresponding weak staining in the adjacent spleen.
  • CD34 staining pattern was identical in both the spleen and the SH.
  • [MeSH-major] Hamartoma / pathology. Spleen / pathology. Splenic Diseases / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / metabolism. Biomarkers / metabolism. Child, Preschool. Diagnosis, Differential. Factor VIII / metabolism. Female. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Immunohistochemistry. Treatment Outcome. Weibel-Palade Bodies / ultrastructure

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  • (PMID = 15735864.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 9001-27-8 / Factor VIII
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48. Völk M, Strotzer M: [Diagnostic imaging of splenic disease]. Radiologe; 2006 Mar;46(3):229-43; quiz 244
MedlinePlus Health Information. consumer health - Spleen Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic imaging of splenic disease].
  • Primary diseases of the spleen are relatively rare.
  • More frequently, the spleen is involved secondarily in hematological, oncological, infectious, immunological, vascular, and other systemic diseases.
  • The spleen is the most commonly injured organ in blunt abdominal trauma.
  • Anatomical and physiological basics are explained, in addition to embryological facts with resulting abnormalities, such as accessory and "wandering" spleen, and polysplenia.
  • The most frequent primary and secondary diseases of the spleen, including rare diagnoses, are presented and illustrated.
  • Hemangioma represents the most common primary benign tumor, and lymphoma the most common primary malignant tumor of the spleen.
  • Additional clarification using CT or MRT should be reserved for cases with a strong suspicion of clinically relevant primary or secondary splenic disease.
  • [MeSH-major] Diagnostic Imaging / methods. Image Enhancement / methods. Spleen / diagnostic imaging. Spleen / pathology. Splenic Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Radiography

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  • [Cites] Clin Radiol. 1997 Jul;52(7):535-40 [9240707.001]
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  • (PMID = 16435091.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 24
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49. Chourmouzi D, Psoma E, Drevelegas A: Littoral cell angioma, a rare cause of long standing anaemia: a case report. Cases J; 2009;2:9115

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral cell angioma, a rare cause of long standing anaemia: a case report.
  • Littoral cell angioma is a rare primary splenic tumor that is difficult to differentiate preoperatively from other benign and malignant splenic lesions.
  • We report a case of littoral cell angioma of the spleen in a 51-year-old woman that presented with long standing anaemia.

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  • [Cites] Clin Imaging. 2007 Jan-Feb;31(1):27-31 [17189843.001]
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  • (PMID = 20062692.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803912
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50. Warshauer DM, Hall HL: Solitary splenic lesions. Semin Ultrasound CT MR; 2006 Oct;27(5):370-88
MedlinePlus Health Information. consumer health - Spleen Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary splenic lesions.
  • Solitary splenic lesions are unusual.
  • A differential diagnosis can be organized around their basic imaging appearance as either predominantly cystic or solid.
  • Solid lesions include both nonneoplastic lesions such as splenic hamartoma, benign tumors such as hemangioma and malignant masses including lymphoma and angiosarcoma.
  • Percutaneous biopsy may be used for histologic diagnosis when required.
  • [MeSH-major] Spleen / abnormalities. Splenic Diseases / radiography
  • [MeSH-minor] Abscess / radiography. Abscess / radionuclide imaging. Cysts / radiography. Cysts / radionuclide imaging. Diagnosis, Differential. Humans. Splenic Neoplasms / radiography. Splenic Neoplasms / radionuclide imaging. Tomography, X-Ray Computed

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  • (PMID = 17048453.001).
  • [ISSN] 0887-2171
  • [Journal-full-title] Seminars in ultrasound, CT, and MR
  • [ISO-abbreviation] Semin. Ultrasound CT MR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 121
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51. Gamlem H, Nordstoga K, Arnesen K: Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs. APMIS Suppl; 2008;(125):41-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A distinction is made between benign neoplasms, tumours of intermediate malignancy, and obvious malignant processes (angiosarcomas).
  • More than one half (242 of 439) occurred in the skin, and a great majority of skin processes (223 of 242) represented benign tumours or tumour-like lesions.
  • The next most common site of summarised lesions was the spleen, with 110 cases, with only 17 processes in this organ being defined as benign.
  • Splenic involvement was followed by the liver, with 13 out of 17 processes being angiosarcomas.
  • Recurrence occurred in 17 dogs, some of which had received a primary benign diagnosis.
  • Primary metastases were observed in 63 animals, the majority in the spleen and heart.
  • The male/female rate of benign tumours was 0.78, for tumour-like processes 1.83, intermediate malignant tumours 1.65, and angiosarcomas 1.60.
  • [MeSH-minor] Animals. Dogs. Female. Hemangioma / pathology. Hemangioma / veterinary. Hemangiosarcoma / pathology. Hemangiosarcoma / veterinary. Lymphangioma / pathology. Lymphangioma / veterinary. Male

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  • (PMID = 19385280.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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52. Kosmidis C, Efthimiadis C, Anthimidis G, Grigoriou M, Vasiliadou K, Sfikakis P, Tziris N, Fahantidis E: Elective laparoscopic splenectomy for giant hemangioma: a case report. Cases J; 2009;2(1):10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elective laparoscopic splenectomy for giant hemangioma: a case report.
  • Although unusual, hemangioma is the most common primary splenic neoplasm.
  • We present herein a case of an 18-year-old male asymptomatic patient who underwent laparoscopic splenectomy for the incidental finding of splenomegaly caused by a large splenic hemangioma.
  • Laparoscopic splenectomy appears to be a safe and effective procedure, in appropriately experienced hands, for patients with splenomegaly, given the spleen's fragile anatomy and its relationship to other abdominal viscera.

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  • (PMID = 19123949.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2631531
  •  go-up   go-down


53. Makrin V, Avital S, White I, Sagie B, Szold A: Laparoscopic splenectomy for solitary splenic tumors. Surg Endosc; 2008 Sep;22(9):2009-12
MedlinePlus Health Information. consumer health - Spleen Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic splenectomy for solitary splenic tumors.
  • BACKGROUND: Solitary splenic masses are a rare entity.
  • There is a paucity of data in the literature on the evaluation and laparoscopic treatment for splenic masses.
  • To further elucidate the evaluation and laparoscopic management of splenic masses we evaluated our own data.
  • MATERIALS AND METHODS: Data was collected retrospectively for all patients who underwent laparoscopic splenectomy (LS) in our institution for the diagnosis of a solid mass.
  • RESULTS: 28 patients underwent LS for solid splenic masses between 1997 and 2006.
  • Fifty-three percent were asymptomatic at diagnosis.
  • Three patients (10.7%) had multiple splenic lesions.
  • Conversion rate was 14.3%.
  • In three patients (10.7%) the spleen was removed with additional organs' tissue (stomach and pancreas).
  • Pathology revealed eight patients (28%) with benign tumors and the rest (71.4%) with malignant lymphoma.
  • CONCLUSIONS: Splenic solid tumor is a rare entity.
  • The most common benign lesion was inflammatory pseudotumor.
  • This study has demonstrated the feasibility and safety of LS for diagnosis and treatment of both benign and malignant tumors of the spleen.
  • [MeSH-major] Laparoscopy / methods. Lymphoma, Non-Hodgkin / surgery. Splenectomy / methods. Splenic Diseases / surgery. Splenic Neoplasms / surgery
  • [MeSH-minor] Adult. Aged, 80 and over. Cysts / surgery. Feasibility Studies. Female. Granuloma, Plasma Cell / surgery. Hamartoma / surgery. Hemangioma / surgery. Humans. Male. Middle Aged. Postoperative Complications. Retrospective Studies

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  • (PMID = 18594922.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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54. Colović R, Suvajdzić N, Grubor N, Colović N, Terzić T: Atypical immunophenotype in a littoral cell angioma. Vojnosanit Pregl; 2009 Jan;66(1):63-5
MedlinePlus Health Information. consumer health - Birthmarks.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical immunophenotype in a littoral cell angioma.
  • BACKGROUND: Littoral-cell angioma (LCA) is a recently described benign vascular tumor of the spleen, whose imaging and pathologic characteristics have been discussed only by a few authors.
  • The tumor is characterized by a mixture of papillary and cystic areas lined by neoplastic cells deriving from normal splenic lining--littoral cells.
  • The neoplastic LCA cells express both endothelial and histiocytic antigens associated with CD8 negativity, compared with the normal endothelium of the venous sinuses of the spleen red pulp that only expresses endothelial antigens and CD8 positivity.
  • CASE REPORT: We reported a 60-year-old male with moderate nodular splenomegaly with one large hypoechogenic solid lesion and mild thrombocytopenia in whom the diagnosis of LCA was made after the elective splenectomy.
  • Namely, histopathological and immunohistochemical data allowed a final diagnosis of classical LCA in spite of CD21 negativity.
  • CONCLUSION: Littoral-cell angioma is a very rare benign splenic neoplasm that should be considered in the differential diagnosis of multinodular splenomegaly, particularly if the patient has the signs of hypersplenism.
  • [MeSH-major] Hemangioma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 19195267.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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55. Tang XF, Zhang WY, Li GD, Jiang LL, Liu WP: [Splenic lymphangioma: clinicopathologic and immunohistochemical study of 18 cases and review of literature]. Zhonghua Bing Li Xue Za Zhi; 2007 Feb;36(2):98-101
Genetic Alliance. consumer health - Lymphangioma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Splenic lymphangioma: clinicopathologic and immunohistochemical study of 18 cases and review of literature].
  • OBJECTIVE: To study the clinicopathologic features and differential diagnosis of splenic lymphangioma.
  • METHODS: Eighteen cases of splenic lymphangioma were retrieved from the pathology archives during the period between January 1990 to December 2005.
  • Gross examination showed splenic enlargement.
  • Histologically, splenic lymphangioma could be subclassified as cavernous (9/18), cystic (5/18) or mixed (4/18).
  • CONCLUSIONS: Splenic lymphangioma is a rarely encountered entity that can be misdiagnosed as a splenic hemangioma.
  • A definite diagnosis depends on pathologic examination.
  • [MeSH-major] Antigens, CD / metabolism. Lymphangioma / pathology. Membrane Glycoproteins / metabolism. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal / metabolism. Antibodies, Monoclonal, Murine-Derived. Antigens, CD9. Biomarkers, Tumor / metabolism. Child. Diagnosis, Differential. Female. Follow-Up Studies. Hemangioma / metabolism. Hemangioma / pathology. Humans. Immunohistochemistry. Lymphangioma, Cystic / metabolism. Lymphangioma, Cystic / pathology. Lymphangioma, Cystic / surgery. Male. Middle Aged. Splenectomy

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  • (PMID = 17493383.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD; 0 / Antigens, CD9; 0 / Biomarkers, Tumor; 0 / CD9 protein, human; 0 / Membrane Glycoproteins; 0 / monoclonal antibody D2-40
  • [Number-of-references] 7
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56. Kim HG, Park IS, Lee JI, Jeong S, Lee JW, Kwon KS, Lee DH, Kim PS, Kim HG, Shin YW, Kim YS, Ahn IS, Lee KY: Littoral cell angioma (LCA) associated with liver cirrhosis. Yonsei Med J; 2005 Feb 28;46(1):184-8
MedlinePlus Health Information. consumer health - Cirrhosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral cell angioma (LCA) associated with liver cirrhosis.
  • A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen.
  • Because there was no evidence of hematological and visceral malignancy, a splenectomy was performed for a definitive diagnosis.
  • The histological and immunohistochemical features of the splenic specimens were consistent with a LCA.
  • [MeSH-major] Hemangioma / complications. Liver Cirrhosis / complications. Splenic Neoplasms / complications

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  • (PMID = 15744827.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2823050
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57. Fagen K, Singer M, Braatz S, Ferrara S: Embolization of a splenic hemangioma in pregnancy. J Vasc Interv Radiol; 2009 Apr;20(4):559-60
MedlinePlus Health Information. consumer health - Tumors and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Embolization of a splenic hemangioma in pregnancy.
  • [MeSH-major] Embolization, Therapeutic / methods. Hemangioma / therapy. Pregnancy Complications, Neoplastic / therapy. Splenic Neoplasms / therapy

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  • (PMID = 19216092.001).
  • [ISSN] 1535-7732
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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58. Noghrehkar D, Hohman D, Ragland S: Spontaneous rupture of splenic hemangioma in hepatitis C virus-related cirrhosis. Eur J Intern Med; 2008 Oct;19(6):e40-1
MedlinePlus Health Information. consumer health - Spleen Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous rupture of splenic hemangioma in hepatitis C virus-related cirrhosis.
  • [MeSH-major] Hemangioma / etiology. Hepatitis C / complications. Liver Cirrhosis / complications. Splenic Diseases / etiology. Splenic Rupture / etiology


59. Pérez-Chávez G, Escárcega RO, Salazar-Ibarguen J, García-Carrasco M: [Splenic hemangioma]. Gac Med Mex; 2007 Nov-Dec;143(6):523-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Splenic hemangioma].
  • [Transliterated title] Hemangioma esplénico.
  • [MeSH-major] Hemangioma. Splenic Neoplasms

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  • (PMID = 18269085.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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60. Wilsher MJ: Littoral cell angioma and splenic lipogranulomata in a renal dialysis patient with chronic left loin pain. Pathology; 2006 Jun;38(3):277-9
MedlinePlus Health Information. consumer health - Birthmarks.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral cell angioma and splenic lipogranulomata in a renal dialysis patient with chronic left loin pain.
  • [MeSH-major] Epithelioid Cells / pathology. Flank Pain / pathology. Granuloma / pathology. Hemangioma / pathology. Histiocytes / pathology. Splenic Neoplasms / pathology

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  • (PMID = 16753761.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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61. Bhatt S, Huang J, Dogra V: Littoral cell angioma of the spleen. AJR Am J Roentgenol; 2007 May;188(5):1365-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Littoral cell angioma of the spleen.
  • [MeSH-major] Hemangioma / radiography. Splenic Neoplasms / radiography

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  • (PMID = 17449783.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Achour A, Filali MA, Benabdellah C, Elhassani R, Poinsard M: [Littoral cell angioma of the spleen]. J Chir (Paris); 2006 Nov-Dec;143(6):388
MedlinePlus Health Information. consumer health - Birthmarks.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Littoral cell angioma of the spleen].
  • [MeSH-major] Hemangioma / pathology. Hemangioma / surgery. Spleen / pathology. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Middle Aged. Splenectomy. Splenomegaly / diagnosis. Splenomegaly / etiology. Splenomegaly / ultrasonography

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  • (PMID = 17285086.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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63. Vetter S, Zeller J, Fellbaum C: [Angioma of the spleen as an accidental finding]. Rofo; 2007 Nov;179(11):1195-6
MedlinePlus Health Information. consumer health - Birthmarks.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angioma of the spleen as an accidental finding].
  • [Transliterated title] Littoralzell-Angiom der Milz als Zufallsbefund.
  • [MeSH-major] Abdominal Pain / radiography. Hemangioma / pathology. Hemangioma / radiography. Incidental Findings. Splenic Neoplasms / pathology. Splenic Neoplasms / radiography

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  • (PMID = 17948199.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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64. Morgenstern L: Hemangioma of the spleen. J Am Coll Surg; 2007 Aug;205(2):386
MedlinePlus Health Information. consumer health - Spleen Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemangioma of the spleen.
  • [MeSH-major] Hemangioma / surgery. Splenectomy. Splenic Diseases / surgery

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  • [CommentOn] J Am Coll Surg. 2007 Jan;204(1):179-81 [17189129.001]
  • (PMID = 17660089.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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65. Floyd JD, Kaplan PA, Sauter ER, Perry MC, Doll DC: Patients with unusual bladder malignancies and a rare cause of splenomegaly. Case 3. Littoral cell angioma of the spleen in a patient with previous lymphoma. J Clin Oncol; 2005 Jul 1;23(19):4460-2
MedlinePlus Health Information. consumer health - Lymphoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patients with unusual bladder malignancies and a rare cause of splenomegaly. Case 3. Littoral cell angioma of the spleen in a patient with previous lymphoma.
  • [MeSH-major] Hemangioma / diagnosis. Lymphoma / therapy. Splenic Neoplasms / diagnosis. Splenomegaly / etiology

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  • (PMID = 15994157.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Wang CN, He XL, Zhang HB, Ding HX: [Littoral cell angioma of the spleen in a patient with chronic hepatitis B and hepatocellular carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Dec;36(12):858-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Littoral cell angioma of the spleen in a patient with chronic hepatitis B and hepatocellular carcinoma].
  • [MeSH-major] Carcinoma, Hepatocellular / complications. Hemangioma / complications. Hemangioma / diagnosis. Hepatitis B, Chronic / complications. Spleen / pathology

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  • (PMID = 18346365.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31
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