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6. Eandi JA, Asuncion A, Vandewalker KN, Javidan J: Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma. Int J Urol; 2007 Sep;14(9):862-4
MedlinePlus Health Information. consumer health - Bladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma.
  • Granular cell tumor of the bladder is exceptionally rare, with only 11 cases reported in the published reports.
  • Pseudoepitheliomatous hyperplasia of the overlying squamous epithelium has been observed in non-bladder granular cell tumors.
  • We herein report the first case of bladder granular cell tumor to exhibit pseudoepitheliomatous hyperplasia.
  • This phenomenon is significant as it may potentially lead to difficulty in the distinction between infiltrative squamous cell carcinoma and pseudoepitheliomatous hyperplasia in cases of granular cell tumor of the bladder.
  • This case also represents the first granular cell tumor to demonstrate colocalization with adenocarcinoma of the bladder.
  • Based on our findings and a review of the published reports, management for granular cell tumor of the bladder should involve a course of local resection combined with active surveillance given its typical benign course, albeit with the potential for local recurrence.
  • [MeSH-major] Adenocarcinoma / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17760758.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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7. Khalid K, Alam MK, Al-Shakweer WA, Al-Teimi IN: Granular cell tumour of the ampulla of Vater. J Postgrad Med; 2005 Jan-Mar;51(1):36-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumour of the ampulla of Vater.
  • Granular cell tumour (GCT) is a rare soft tissue neoplasm commonly encountered in the head and neck region, skin and subcutaneous tissue.
  • The neoplasm constitutes less than 10% of all benign tumours of the extra-hepatic biliary tree.
  • We report a case of benign GCT involving the ampullary region in a 44-year-old Ethiopian male.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 15793336.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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8. Cheewakriangkrai C, Sharma S, Deeb G, Lele S: A rare female genital tract tumor: benign granular cell tumor of vulva: case report and review of the literature. Gynecol Oncol; 2005 May;97(2):656-8
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare female genital tract tumor: benign granular cell tumor of vulva: case report and review of the literature.
  • BACKGROUND: The granular cell tumor (GCT) of vulva is a rare female genital tract tumor.
  • Histologic examination of the tumor showed sheets and clusters of infiltrating tumor cells with morphologic features consistent with granular cell tumor.
  • CONCLUSION: Although benign and slow growing, it has a tendency for recurrence and can cause morbidity and mortality when presenting with multicentric or multiple organ involvement due to the lack of effective systemic therapy.
  • [MeSH-major] Granular Cell Tumor / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 15863174.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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9. Arican O, Ciralik H, Sasmaz S: Multiple plaques on the back: S-100 negative benign granular cell tumor. J Dermatol; 2005 Jul;32(7):585-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple plaques on the back: S-100 negative benign granular cell tumor.
  • Granular cell tumor is a rarely seen disease characterized by a gradually developing nodular lesion, which is difficult to diagnose.
  • The tumor usually appears in the 4th-6th decades of life, more frequently in women and blacks, and has a multifocal location in 10-25% of the cases.
  • The present paper describes an 18-year-old female patient with benign granular cell tumor.
  • This rarely seen type of tumor was S-100 negative and has been detected in biopsies taken from multiple asymptomatic plaques and maculopapular lesions.
  • [MeSH-major] Granular Cell Tumor / pathology. S100 Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 16335876.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / S100 Proteins
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10. Sartorius C, Plechata B, Luis W, Kempf HG: [Granular cell tumor -- a rare tumor lesion of submandibular gland origin]. Laryngorhinootologie; 2005 Oct;84(10):755-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor -- a rare tumor lesion of submandibular gland origin].
  • [Transliterated title] Granularzelltumor, ein seltener Tumor der Glandula submandibularis.
  • RATIONALE: Granular cell tumors are rare entities with manifestations in nearly all organ systems.
  • CASE REPORT: We report a 54 years old female patient with a painless submandibular tumor lesion.
  • Using a submandibular approach the tumor was totally removed with the submandibular gland.
  • Histologically a benign granular cell tumor was diagnosed.
  • The clinical follow-up for about 3 years was without complications or tumor recidive.
  • CONCLUSIONS: A differential diagnosis of a submandibular mass is the rare manifestation of a benign granular cell tumor.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Middle Aged. S100 Proteins / analysis. Submandibular Gland / pathology. Submandibular Gland / surgery. Vimentin / analysis

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  • (PMID = 16231244.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin
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11. Fang HY, Wu CY, Huang HJ, Lin YM: Granular cell tumor of the lung. Lung; 2010 Aug;188(4):355-7
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the lung.
  • A thoracoscopic RML lobectomy was then performed and immunohistochemical study and Ki-67 proliferative index on the pathology sample demonstrated a benign granular cell tumor.
  • Thirty-six months after surgery, the patient remains symptom-free and there has been no recurrence of the tumor on follow-up CT scan.
  • [MeSH-major] Granular Cell Tumor / diagnostic imaging. Lung Neoplasms / diagnostic imaging

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  • [Cites] Pediatr Pulmonol. 2000 Nov;30(5):425-8 [11064434.001]
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  • (PMID = 20066540.001).
  • [ISSN] 1432-1750
  • [Journal-full-title] Lung
  • [ISO-abbreviation] Lung
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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12. Cserni G, Bori R, Sejben I: Vascular invasion demonstrated by elastic stain-a common phenomenon in benign granular cell tumors. Virchows Arch; 2009 Feb;454(2):211-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vascular invasion demonstrated by elastic stain-a common phenomenon in benign granular cell tumors.
  • Granular cell tumor is generally benign, but rare malignant cases have been documented.
  • Venous invasion was incidentally identified with the orcein elastic stain in an otherwise benign granular cell tumor (propositus case).
  • Four further benign granular cell tumors were also analyzed; venous invasion was discovered in three.
  • It is suggested that vascular invasion is not uncommon in granular cell tumors and should not lead to the classification of the tumor as malignant or atypical.
  • [MeSH-major] Blood Vessels / pathology. Elastic Tissue / pathology. Granular Cell Tumor / pathology. Staining and Labeling / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Neoplasm Invasiveness

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  • [Cites] Dis Colon Rectum. 2007 Nov;50(11):1867-72 [17665249.001]
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  • (PMID = 19066954.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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13. Stieglitz F, Kitz R, Schäfers HJ, Eickmeier O, Rose M, Fellbaum C, Zielen S: Granular cell tumor of the trachea in a child. Ann Thorac Surg; 2005 Feb;79(2):e15-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the trachea in a child.
  • Granular cell tumors are uncommon benign neoplasms.
  • We present the case of a 14-year-old girl with a granular cell tumor of the trachea.
  • The tumor was incidentally found at bronchoscopy performed to exclude suspected foreign body aspiration.
  • Biopsies revealed the histologic pattern of a benign granular cell tumor.
  • She has not had any recurrence of the tumor during 3 years of follow-up.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Granular Cell Tumor / surgery. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / surgery

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  • (PMID = 15680798.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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4. Rodriguez y Baena R, Di Ieva A, Colombo P, Collini P, Navarria P, Scorsetti M, Gaetani P, Santoro A: Intramedullary astrocytoma with granular cell differentiation. Neurosurg Rev; 2007 Oct;30(4):339-43; discussion 343

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary astrocytoma with granular cell differentiation.
  • Granular cell astrocytomas are uncommon tumors of the central nervous system (CNS) of which no cases have been documented in the spinal cord.
  • This variant of glioma should not be confused with benign granular cell tumor which, although rare, has been well characterized in the spinal cord.
  • At surgery, the tumor was found to be infiltrating a posterior column with no dural attachment.
  • The histological diagnosis was astrocytoma with granular cell differentiation.
  • In addition to documenting a unique example of intramedullary granular cell astrocytoma, we review the literature to investigate differences from other tumors with granular changes described in the spinal cord.

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  • (PMID = 17483971.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent granular cell tumor: how to treat.
  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The mass was excised two times at different centers and diagnosed as granular cell tumor after the pathologic examination.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Arevalo C, Maly B, Eliashar R, Gross M: Laryngeal granular cell tumor. J Voice; 2008 May;22(3):339-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laryngeal granular cell tumor.
  • Granular cell tumor (GCT) of the larynx is an uncommon, benign laryngeal neoplasm.
  • Abrikossoff first described the tumor in 1926 as myoblastoma.
  • The origin of this tumor has been debated in the literature.
  • Most of the authors believe that the tumor is of neural origin due to the characteristic immunohistochemical-staining pattern.
  • The authors describe two cases of laryngeal GCTs located in different sites with a review of the histological and clinical features, the differential diagnosis, and the treatment and the prognosis of the tumor.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Laryngeal Neoplasms / diagnosis. Vocal Cords

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  • (PMID = 17134875.001).
  • [ISSN] 0892-1997
  • [Journal-full-title] Journal of voice : official journal of the Voice Foundation
  • [ISO-abbreviation] J Voice
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Devi K, Mohanty P, Mohanty L, Bhuyan P, Mishra A, Hazra K: Cytodiagnosis of granular cell tumor: a case report. Indian J Pathol Microbiol; 2007 Jan;50(1):61-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytodiagnosis of granular cell tumor: a case report.
  • Fine needle aspiration diagnosis was benign granular cell tumor which was confirmed by histopathology.
  • Since it is an uncommon tumor, of controversial histogenesis, it is being reported here.
  • [MeSH-major] Granular Cell Tumor / diagnosis

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  • (PMID = 17474262.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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18. Pino Rivero V, Marcos García M, Rejas Ugena E, Trinidad Ruiz G, Pardo Romero G, González Palomino A, Gómez de Tejada Romero R, Blasco Huelva A: [Granular cell tumor of the tongue (Abrikossoff's tumor). Report of a case and review of the literature]. An Otorrinolaringol Ibero Am; 2005;32(1):65-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the tongue (Abrikossoff's tumor). Report of a case and review of the literature].
  • [Transliterated title] Tumor de células granulares lingual (tumor de Abrikossoff). Presentación de un caso y revisión de la literatura.
  • Granular cell tumor, myoblastoma or Abrikossoff's tumor is an uncommon benign lesion, usually of slow-growing, that shows a predilection for the oral cavity, especially the tongue.
  • Its real etiopathogenia remains still controversial and in it's histogenesis have been implicated several cell types.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 15803921.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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19. Rego A, Amado J, Esteves I, Almeida J, Furtado A, Couceiro A, Moura e Sá J: [Endobronchial granular cell tumor - what approach to take]. Rev Port Pneumol; 2006 Jul-Aug;12(4):463-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endobronchial granular cell tumor - what approach to take].
  • [Transliterated title] Tumor de células granulares endobrônquico - Como abordamos?
  • Granular cell tumor is a mesenchymal neoplasm almost always benign, with tendency to recurrence.
  • The authors describe two cases of endobronchial granular cell tumours, discuss the particularities of this pathology as well as the treatment options, with particular attention to the use of endobronchial excision and criotherapy.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / therapy. Granular Cell Tumor / diagnosis. Granular Cell Tumor / therapy

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  • (PMID = 16969575.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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20. Józefowicz-Korczyńska M, Kozłowski Z, Pietruszewska W, Lukomski M: [Granular-cell myoblastoma of the larynx clinical analysis]. Otolaryngol Pol; 2005;59(6):807-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular-cell myoblastoma of the larynx clinical analysis].
  • Clinical date of four cases of granular-cell myoblastoma tumors arising in the larynx and clinical analysis of 11 cases published in Polish literature were reviewed and studied.
  • Granular-cell tumor is a rare, usually benign neoplasm that can occur in various part of the body.
  • The larynx tumor is accounting for 7% to 10% of all reported cases.
  • The tumor was generally presented in patients in their forth and fifth decade.
  • Clinically the tumors were considered benign.
  • In one case because the location and size of the tumor subtotal laryngectomy was necessary to conduct.
  • [MeSH-major] Granular Cell Tumor / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16521442.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 18
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21. Eriksen JR, Ibsen PH, Gyrtrup HJ: [Granular cell tumor of the colon--Abrikossoff's tumor]. Ugeskr Laeger; 2006 May 22;168(21):2080-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the colon--Abrikossoff's tumor].
  • [Transliterated title] Granularcelletumor i colon--Abrikossoffs tumor.
  • Histopathologic examination of the specimen showed a tubulovillous adenoma with moderate dysplasia and an adjacent 1 x 1 cm submucosal tumor classified as a benign GCT due to the appearance in the light microscope and immunohistochemical analysis.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 16768929.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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22. Torrijos-Aguilar A, Alegre-de Miquel V, Pitarch-Bort G, Mercader-García P, Fortea-Baixauli JM: [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases]. Actas Dermosifiliogr; 2009 Mar;100(2):126-32
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases].
  • [Transliterated title] Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos.
  • BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells.
  • OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature.
  • METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases).
  • CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
  • [MeSH-major] Granular Cell Tumor / epidemiology. Mouth Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Child, Preschool. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Female. Fibroma / diagnosis. Humans. Male. Middle Aged. Retrospective Studies. Skin Neoplasms / chemistry. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Staining and Labeling. Young Adult

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  • (PMID = 19445877.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Garrido E, Marín E, González C, Juzgado D, Boixeda D, Vázquez-Sequeiros E: [Endoscopic mucosal resection of Abrikosoff's tumor of the esophagus]. Gastroenterol Hepatol; 2008 Nov;31(9):572-5
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  • [Title] [Endoscopic mucosal resection of Abrikosoff's tumor of the esophagus].
  • [Transliterated title] Mucosectomía endoscópica de un tumor de Abrikosoff esofágico.
  • Abrikosoff's tumor (AT), or granular cell tumor (GCT), is relatively rare in the gastrointestinal tract, where the most common site is the esophagus.
  • This tumor is usually found incidentally when an upper gastrointestinal endoscopy is carried out for another reason.
  • The origin of GCT is neurogenic and the tumor is composed of eosinophilic granular cytoplasm and PAS-positive cells, which show the S-100 protein on immunohistochemistry.
  • Although GCT is usually clinically and histologically benign, some malignant cases have been reported.
  • Consensus is lacking on the treatment and follow-up of this tumor.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagoscopy. Granular Cell Tumor / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 19091245.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / S100 Proteins
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24. Basu D, Sengupta A, Adhikari D, Dam A, Anwar T: Granular cell myoblastoma of the tongue in a 2-year-old girl: a case report. J Indian Med Assoc; 2010 Mar;108(3):170, 175
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  • [Title] Granular cell myoblastoma of the tongue in a 2-year-old girl: a case report.
  • Granular cell tumours are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions.
  • It is not clear whether or not granular cell tumour is a true neoplasm, a developmental anomaly, or a trauma-induced proliferation.
  • The basic cell of origin is now thought to be neural, although past reports frequently indicated an origin from striated muscle, or less frequently an origin from histiocytes, fibroblasts or pericytes.
  • More than a third of all granular cell tumours occur on the lingual dorsum, usually as a sessile, painless, somewhat firm, immoveable nodule less than 1.5 cm in greatest diameter.
  • As most of the granular cell tumours are benign, surgical excision of the lesion is the treatment of choice.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21043356.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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25. Loncar B, Marjanović K, Pauzar B, Staklenac B: Granular cell tumor--clinically presented as lymphadenopathy. Coll Antropol; 2010 Mar;34(1):261-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor--clinically presented as lymphadenopathy.
  • Granular cell tumors are relatively uncommon benign lesions occurring in almost any part of the body.
  • We report the cytological diagnosis of granular cell tumor in 25-year-old male patient who presented with an inguinal mass clinically suspected to be a lymphadenopathy.
  • Fine needle aspiration revealed polygonal cells with abundant, granular cytoplasm and eccentrically located vesicular nuclei and inconspicuous nucleoli.
  • If resection is complete, local surgical excision is curative for benign granular cell tumors.
  • Granular cell tumor has a characteristic cytological appearance, and fine-needle aspiration cytology has been suggested to be diagnostic modality of choice.
  • [MeSH-major] Biopsy, Fine-Needle. Granular Cell Tumor / pathology. Lymphatic Diseases / pathology. Neoplasms / pathology

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  • (PMID = 20432759.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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26. Ayadi L, Khabir A, Fakhfakh I, Abdelmoula MH, Makni S, Sellami Boudawara T: [Granular cell tumor]. Rev Stomatol Chir Maxillofac; 2008 Jun;109(3):158-62
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  • [Title] [Granular cell tumor].
  • The granular cell tumor (GCT) or Abrikossoff tumor is a neurogenic tumor often benign with a predominant cervicofacial localization.
  • It is a rare tumor (0.019 to 0.03% of all tumors).
  • Nevertheless, the tumor may be mistaken for a malignant one, especially in case of shallow biopsy.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Head and Neck Neoplasms / diagnosis

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  • (PMID = 18533209.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 24
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27. Guven S, Kaymakci A, Bugday MS, Yilmaz M: Congenital granular cell tumor. J Craniofac Surg; 2009 May;20(3):976-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital granular cell tumor.
  • Congenital granular cell tumor or congenital epulis is a rare benign soft tissue lesion in newborns.
  • We reported a case of a 1-hour-old female newborn with a congenital granular cell tumor in the anterior maxillary alveolar ridge.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Collagen / ultrastructure. Cytoplasm / pathology. Female. Follow-Up Studies. Humans. Infant, Newborn. Maxilla. Phosphopyruvate Hydratase / analysis. Vimentin / analysis

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  • (PMID = 19461349.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin; 9007-34-5 / Collagen; EC 4.2.1.11 / Phosphopyruvate Hydratase
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28. Rudisaile SN, Hurt MA, Santa Cruz DJ: Granular cell atypical fibroxanthoma. J Cutan Pathol; 2005 Apr;32(4):314-7
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  • [Title] Granular cell atypical fibroxanthoma.
  • We report on two patients with granular cell atypical fibroxanthoma.
  • Microscopically, these neoplasms showed a dermal proliferation of pleomorphic granular cells with irregular hyperchromatic nuclei, multinucleated cells, and scattered mitoses.
  • The differential diagnosis of granular cells in neoplasms containing cytological pleomorphism is challenging in view of the many different neoplasms that may present with granular cytoplasm.
  • These include the conventional granular cell tumor and its malignant form, leiomyoma, leiomyosarcoma, dermatofibroma, dermatofibrosarcoma protuberans, and angiosarcoma.
  • [MeSH-major] Granular Cell Tumor / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor. Humans. Immunohistochemistry. Male. Mohs Surgery. Treatment Outcome

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  • (PMID = 15769283.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 25
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29. Thacker MM, Humble SD, Mounasamy V, Temple HT, Scully SP: Case report. Granular cell tumors of extremities: comparison of benign and malignant variants. Clin Orthop Relat Res; 2007 Feb;455:267-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report. Granular cell tumors of extremities: comparison of benign and malignant variants.
  • Granular cell tumors are uncommon soft tissue neoplasms that arise from cells of neural origin.
  • We present three patients with this rare tumor: one with a benign tumor, one with a malignant tumor, and one with a histologically benign tumor that later metastasized to the lung.
  • We studied the difficulty in differentiating between the benign and malignant variants using only histology.
  • [MeSH-major] Granular Cell Tumor / pathology

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  • (PMID = 16936589.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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30. Pertile D, Scabini S, Romairone E, Scordamaglia R, Rimini E, Ferrando V: Gastric Abrikosoff tumor (granular cell tumor): case report. G Chir; 2010 Oct;31(10):433-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric Abrikosoff tumor (granular cell tumor): case report.
  • Granular Cells Tumor (GCT), also called Abrikosoff tumor, is very uncommon lesion of neural derivation.
  • It is characterized by the presence of granular cell; benign and malignamt counterparts are known, even if the second ones are rare.
  • Surgical en-block excision is curative for both benign an malignant forms.
  • We report the case of a 45 year old man who had a cytologic diagnosis of fusocellular stromal tumor of the gastric fundus during examination for gastritis.
  • He underwent a wedge resection of the gastric wall: at the histological examination neoplastic cells had a granular cytoplasm and immunoassay was positive for S100 protein, PGP 9.5 and NSE.
  • [MeSH-major] Granular Cell Tumor. Stomach Neoplasms

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  • (PMID = 20939949.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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31. Vered M, Dobriyan A, Buchner A: Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult. Virchows Arch; 2009 Mar;454(3):303-10
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  • [Title] Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult.
  • Congenital granular cell epulis (CGCE), a rare benign lesion arising from the mucosa of the alveolar ridges of the jaws in newborns, has a clinical course characterized by lack of further growth after birth.
  • Histomorphologically, it resembles a granular cell tumor (GCT) of the adult.
  • We submitted a series of five CGCEs to a large panel of antibodies in order to trace the origin of the constituent granular cells.
  • This does not confirm any particular cell type for the histogenetic origin of CGCE but may rather reflect a local metabolic or reactive change, providing supporting evidence that the lesion is of a non-neoplastic nature.
  • In addition, the granular cells were non-reactive for S-100, NGFR/p75, and inhibin-alpha, which further contributes to the distinction between a CGCE and the adult GCT.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gingival Neoplasms / congenital. Gingival Neoplasms / metabolism. Granular Cell Tumor / congenital. Granular Cell Tumor / metabolism
  • [MeSH-minor] Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Cell Lineage. Humans. Immunohistochemistry. Phosphoglucomutase / metabolism. S100 Proteins / metabolism

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  • (PMID = 19205730.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / S100 Proteins; EC 5.4.2.2 / PGM1 protein, human; EC 5.4.2.2 / Phosphoglucomutase
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32. Angiero F, Crippa R, Stefani M: Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery. Minerva Stomatol; 2006 Jul-Aug;55(7-8):423-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery.
  • METHODS: Between 1999 and 2004, 11 patients (6 females, 5 males; age range 28-66 years) were treated for tumours classified as being of neural origin; they were all myoblastomas or granular cells tumours (ex Abrikossoff tumour).
  • CONCLUSIONS: Granular cell tumour is a benign neoplasm with a tendency to relapse if not completely removed.
  • [MeSH-major] Granular Cell Tumor / surgery. Laser Therapy. Mouth Neoplasms / surgery

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  • (PMID = 17041542.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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33. Rinaggio J, Cleveland D, Koshy R, Gallante A, Mirani N: Peripheral granular cell odontogenic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):676-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral granular cell odontogenic fibroma.
  • Peripheral odontogenic fibroma is a rare lesion that arises on the gingiva and can clinically mimic a variety of reactive lesions, benign neoplasms, and metastases.
  • An excisional biopsy showed the lesional stroma to contain numerous polyhedral granular cells with occasional interspersed islands of inactive odontogenic epithelium.
  • We believe this to represent the fourth case of peripheral granular cell odontogenic fibroma to be reported in detail in the literature.
  • [MeSH-major] Fibroma / pathology. Gingival Neoplasms / pathology. Granular Cell Tumor / pathology. Mandibular Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17223586.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Number-of-references] 8
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34. López-Jornet P: Granular cell tumor of the tongue. N Y State Dent J; 2008 Aug-Sep;74(5):71-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the tongue.
  • Granular cell tumor is an uncommon benign hamartomatous lesion occurring in almost any part of the body.
  • Granular cell lesions may be found in other diverse sites, such as the jaw, skin, gastrointestinal tract and respiratory tract.
  • In this paper, we report the occurrence of an oral granular cell tumor affecting the tongue of a 45-year-old male patient.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 18982973.001).
  • [ISSN] 0028-7571
  • [Journal-full-title] The New York state dental journal
  • [ISO-abbreviation] N Y State Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Chelly I, Bellil K, Mekni A, Bellil S, Belhadjsalah M, Kchir N, Haouet S, Zitouna MM: Malignant granular cell tumor of the abdominal wall. Pathologica; 2005 Jun;97(3):130-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant granular cell tumor of the abdominal wall.
  • The granular cell tumor is an uncommon tumor that usually appears as a solitary small nodular growth and runs a benign course.
  • The authors report a case of malignant granular cell tumor which was arising in anterior abdominal wall of a 67-year-old woman.
  • [MeSH-major] Abdominal Neoplasms / pathology. Abdominal Wall / pathology. Granular Cell Tumor / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Fatal Outcome. Female. Humans. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Postoperative Complications. Pulmonary Embolism / complications

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  • (PMID = 16259279.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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36. K C S, Kouzu T, Hishikawa E: Multiple granular cell tumor of the esophagus treated endoscopically. JNMA J Nepal Med Assoc; 2007 Jan-Mar;46(165):40-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple granular cell tumor of the esophagus treated endoscopically.
  • Granular cell tumor (GCT) of esophagus is a rare lesion, usually found incidentally during upper gastrointestinal endoscopic examination undertaken for another reasons.
  • The origin of this neoplasm is still unclear but no organ seems to be immune to this neoplasm.
  • Although most of the lesions are benign, few reports of malignant GCT, synchronous as well as metachronous, are also reported.

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  • (PMID = 17721562.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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37. Sterker I, Hagert-Winkler A, Gradistanac T, Frerich B: [Granular cell tumor of the orbit]. Ophthalmologe; 2007 Sep;104(9):803-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the orbit].
  • Granular cell tumor (GCT, Abrikossoff tumor) is an extremely rare, benign tumor with a neurogenic origin occurring most commonly in the upper aerodigestive tract.
  • [MeSH-major] Granular Cell Tumor. Orbital Neoplasms

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  • (PMID = 17440732.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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38. Sailors JL, French SW: The unique simultaneous occurrence of granular cell tumor, gastrointestinal stromal tumor, and gastric adenocarcinoma. Arch Pathol Lab Med; 2005 May;129(5):e121-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The unique simultaneous occurrence of granular cell tumor, gastrointestinal stromal tumor, and gastric adenocarcinoma.
  • Granular cell tumors are generally benign oncocytoid lesions of schwannian origin that are often incidental findings in many locations.
  • This report is prompted by the simultaneous appearance of 2 granular cell tumors, a gastrointestinal stromal tumor, and a gastric adenocarcinoma in a 65-year-old woman with a history of breast carcinoma and granular cell tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology. Stromal Cells / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry

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  • (PMID = 15859656.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Ilić I, Randelović P, Ilić R, Dordević L, Radojković D: [Granular-cell tumor: a rare variant of mammary tumor]. Vojnosanit Pregl; 2008 Jun;65(6):488-91
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  • [Title] [Granular-cell tumor: a rare variant of mammary tumor].
  • BACKGROUND: Granular cell tumor (GCT) is a rare variant of mammary tumor beset with diagnostic dilemmas that may be resolved by using numerous, very complex, enzymohistochemical and immunohistochemical methods.
  • CASE REPORTS: We reported three female patients 16, 21 and 65 years old, operated on for mammary tumor at the Surgical Clinic of the School of Medicine in Nis, over the period of thirty years, 1977 to 2007.
  • These tumors had benign characteristics, without associated tumors in other localizations.
  • A typical histological feature of GCT was a granular cytoplasm in large ovoid cells, organized like nests or like a trabecular arrangement.
  • The ultrastructural analysis confirmed that the tumor cells were enriched by lysosomes and consequential disorganization of cytoplasm.
  • [MeSH-major] Breast Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 18672708.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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40. Yoon Y, Curry K: Concurrence of granular cell tumor and Mycobacterium tuberculosis. South Med J; 2005 Oct;98(10):1034-5
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  • [Title] Concurrence of granular cell tumor and Mycobacterium tuberculosis.
  • Granular cell tumors (GCT) are rare, usually benign neoplasms of Schwann cell origin.
  • This report reviews the literature regarding GCT and presents this unusual case of granular cell tumor co-occurring with active tuberculosis.
  • [MeSH-major] Granular Cell Tumor / complications. Tuberculosis / complications

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  • (PMID = 16295820.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 2KNI5N06TI / Pyrazinamide; 8G167061QZ / Ethambutol; V83O1VOZ8L / Isoniazid; VJT6J7R4TR / Rifampin
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46. Epstein DS, Pashaei S, Hunt E Jr, Fitzpatrick JE, Golitz LE: Pustulo-ovoid bodies of Milian in granular cell tumors. J Cutan Pathol; 2007 May;34(5):405-9
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  • [Title] Pustulo-ovoid bodies of Milian in granular cell tumors.
  • BACKGROUND: Granular cell tumors (GCTs) are benign neural tumors with a distinct histologic appearance on light microscopy, characterized by eosinophilic cytoplasmic granules.
  • METHODS: We examined the sections of 47 cases of GCT stained with hematoxylin and eosin to determine the frequency of POB within this tumor.
  • When grouped according to clinical characteristics, there was an even distribution of POB by age, sex and site of the tumor.
  • [MeSH-major] Granular Cell Tumor / pathology. Inclusion Bodies / pathology. Skin Neoplasms / pathology

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  • (PMID = 17448196.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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47. Kapur P, Rakheja D, Balani JP, Roy LC, Amirkhan RH, Hoang MP: Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors. Arch Pathol Lab Med; 2007 Jan;131(1):57-64
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  • [Title] Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors.
  • CONTEXT: Granular cell tumors (GCTs) are classified as benign when none of the following features is present: spindling of the tumor cells, necrosis, diffuse pleomorphism, prominent nucleoli, high nuclear-cytoplasmic ratio, and mitotic rate >2 per 10 high-power fields.
  • OBJECTIVE: To compare immunohistochemical staining for phosphorylated histone H3 (PHH3), Ki-67 (MIB-1), p21, fatty acid synthase, and cleaved caspase-3 in histologically classified benign and atypical GCTs.
  • The expression of p21, fatty acid synthase, and cleaved caspase-3 was not significantly different between atypical and benign GCTs.
  • [MeSH-major] Caspase 3 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Fatty Acid Synthases / metabolism. Granular Cell Tumor / metabolism. Histones / metabolism. Ki-67 Antigen / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry / methods. Male. Middle Aged. Mitosis. Necrosis / pathology. Phosphorylation. Retrospective Studies

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  • (PMID = 17227124.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Histones; 0 / Ki-67 Antigen; EC 2.3.1.85 / Fatty Acid Synthases; EC 3.4.22.- / Caspase 3
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48. Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J: Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiol; 2005 Oct;34(10):625-31
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  • [Title] Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.
  • OBJECTIVE: The purpose of this study is to delineate the magnetic resonance (MR) appearance of a granular cell tumor (GrCT) of the extremity and to correlate the imaging appearance with the microscopic findings.
  • DESIGN AND PATIENTS: A retrospective review of five patients with a histopathologic diagnosis of GrCT and pre-operative MR imaging of the neoplasm was done.
  • RESULTS: The benign subtype of GrCT is usually isointense or brighter than muscle on T1-weighted sequences, round or oval in shape, superficial in location, and 4 cm or less in size.
  • On T2-weighted sequences, benign lesions may demonstrate a high peripheral signal, as well as a central signal intensity that is isointense to muscle or suppressed fat.
  • A significant stromal component in the tumor and, hypothetically, a ribbon-like arrangement of tumor cells may influence the signal intensity demonstrated on the T1 and T2-weighted sequences.
  • CONCLUSION: Benign GrCT has imaging characteristics which may distinguish this tumor from other soft tissue neoplasms, as well as the malignant type of this tumor.
  • [MeSH-major] Foot Diseases / pathology. Granular Cell Tumor / pathology. Hand / pathology. Shoulder / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology

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  • [Cites] Skeletal Radiol. 1994 Jan;23 (1):63-6 [8160041.001]
  • [Cites] Cancer. 1977 Apr;39(4):1547-55 [856443.001]
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  • (PMID = 16003548.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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49. Yeh I, Tran DT, Davis TL, Argenyi ZB: An infiltrative variant of non-neural granular cell tumor: a case report. J Cutan Pathol; 2009 Oct;36 Suppl 1:46-51
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  • [Title] An infiltrative variant of non-neural granular cell tumor: a case report.
  • Dermal non-neural granular cell tumors are rare tumors of indeterminate lineage that typically present as well-circumscribed tumors with nuclear pleomorphism and mitotic activity.
  • We describe a dermal non-neural granular cell tumor with a distinctive growth pattern with granular cells interspersed between collagen bundles.
  • This asymptomatic papule arose on the scapula of a 46-year-old woman and consisted of a mixture of epithelioid and spindled granular cells.
  • The immunohistochemical characteristics were similar to those of previously reported dermal non-neural granular cell tumors.
  • Our case could represent a dermal non-neural granular cell tumor with unique architecture, a granular cellular neurothekeoma or a granular cell dermatofibroma.
  • As both dermal non-neural granular cell tumor and cellular neurothekeoma are of indeterminate lineage, our case with features characteristic of both entities may suggest a common precursor or lineage for dermal non-neural granular cell tumor and cellular neurothekeoma.
  • [MeSH-major] Granular Cell Tumor / pathology. Neurothekeoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Humans. Immunohistochemistry. Middle Aged. Scapula / pathology. Scapula / surgery

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  • (PMID = 19187104.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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50. Godoy G, Mufarrij PW, Tsou HC, Torre P, Taneja SS: Granular cell tumor of scrotum: a rare tumor of the male external genitalia. Urology; 2008 Sep;72(3):716.e7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of scrotum: a rare tumor of the male external genitalia.
  • We report a rare case of granular cell tumor in the scrotum.
  • Granular cell tumors are soft-tissue neoplasms originating from Schwann cells that rarely affect male external genitalia.
  • They are essentially benign; therefore, the treatment is complete excision of the lesion.
  • Because the clinical presentation is not specific, the diagnosis of malignant granular cell tumors can be made only by the pathologist.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Genital Neoplasms, Male / pathology. Granular Cell Tumor / diagnosis. Granular Cell Tumor / pathology. Scrotum / pathology

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  • (PMID = 18384852.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Arai E, Nishida Y, Tsukushi S, Sugiura H, Ishiguro N: Intramuscular granular cell tumor in the lower extremities. Clin Orthop Relat Res; 2010 May;468(5):1384-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramuscular granular cell tumor in the lower extremities.
  • Granular cell tumors are uncommon but typically histologically benign neoplasms that occasionally behave as malignant tumors.
  • Differentiation of benign granular cell tumors from malignant counterparts with radiographic and/or histologic analysis is crucial for physicians.
  • We retrospectively studied five cases of intramuscular granular cell tumors arising in the lower extremities.
  • All tumors had been histologically diagnosed as benign and were resected with a wide surgical margin.
  • Intramuscular granular cell tumors can be diagnosed based on their characteristic MRI features, such as peripheral high intensity on T2-weighed images, and histologic evaluation.
  • The histologic criteria described by Fanburg-Smith et al. can differentiate malignant granular cell tumors from benign tumors.
  • A wide resection seems suitable for most granular cell tumors in the extremities.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Leg

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  • [Cites] Clin Orthop Relat Res. 2000 Nov;(380):191-8 [11064991.001]
  • [Cites] Cancer. 2001 Dec 25;93(6):398-408 [11748580.001]
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  • [Cites] Skeletal Radiol. 1997 Feb;26(2):116-21 [9060104.001]
  • (PMID = 19760336.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853648
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52. Laskin WB, Fetsch JF, Davis CJ Jr, Sesterhenn IA: Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. Hum Pathol; 2005 Mar;36(3):291-8
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  • [Title] Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases.
  • The occurrence of granular cell tumor (GCT) in penile tissue is very rare, with only 9 examples reported to date in the English-language literature.
  • Duration of symptoms before surgery ranged from 5 days to 2 years with the presence of an asymptomatic nodule representing the most common tumor-related complaint (n=8).
  • Microscopically, the tumors were moderate to highly cellular and were composed of oval to polygonal-shaped cells with abundant coarsely granular eosinophilic cytoplasm.
  • Tumor cells grew in infiltrating nests, cords, and trabeculae and showed neural (n=2) and vessel wall (n=1) invasion or formed a relatively well-marginated solid nodule.
  • A tumor demonstrated diffuse nuclear atypia and was classified as "atypical."
  • All tumors tested showed moderate to strong immunohistochemical expression of S100 protein (n=6) and low-affinity nerve growth factor receptor (n=5), which was useful for detecting small deposits of tumor and helpful in evaluating surgical margins.
  • Focal tumor cell immunoreactivity was observed for calretinin (4/6 cases) and glial fibrillary acidic protein (1/6 cases).
  • All patients underwent simple (local) excision of their tumor.
  • No patient experienced recurrence or metastatic spread of tumor although surgical margins were microscopically involved by tumor in 5 cases.
  • Benign GCT involving superficial soft tissue of the penis can be adequately managed by a simple excision.
  • [MeSH-major] Granular Cell Tumor / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Calbindin 2. Cell Nucleus / pathology. Cytoplasm / pathology. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Male. Middle Aged. Receptor, Nerve Growth Factor / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Treatment Outcome

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  • (PMID = 15791574.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Glial Fibrillary Acidic Protein; 0 / Receptor, Nerve Growth Factor; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins
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53. Tamborini F, Cherubino M, Scamoni S, Valdatta LA: Granular cell tumor of the toe: a case report. Dermatol Res Pract; 2010;2010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the toe: a case report.
  • Granular cell tumor is a rare tumor of unknown etiology that more commonly affects the oral cavity but can also occur at other sites.
  • The majorities of granular cell tumors are benign and present as a singular dermal nodule.
  • We discuss a case of granular cell tumor of the fourth toe in a 54-year-old patient that was treated with conservative surgery, instead of amputation, and reconstruction with a dermal regeneration template.

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  • (PMID = 20862204.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2938433
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54. Vered M, Carpenter WM, Buchner A: Granular cell tumor of the oral cavity: updated immunohistochemical profile. J Oral Pathol Med; 2009 Jan;38(1):150-9
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  • [Title] Granular cell tumor of the oral cavity: updated immunohistochemical profile.
  • BACKGROUND: Granular cell tumor (GCT) is a benign lesion that occurs at different body sites with preponderance to the oral cavity.
  • It is generally believed to be of schwann cell/neural cell origin.
  • The granular cells demonstrated a wide array of cytological features in terms of cell shape and position of the nucleus.
  • Granular cells were usually found to be strongly and diffusely positive for p75, vimentin, calretinin and NKI/C3, inhibin-alpha, PGP9.5, and S-100.
  • CONCLUSIONS: Immunoreactivity of the granular cells to a broad panel of antibodies that characterize different tissues does not confirm any particular cell type for the histogenetic origin of GCTs.
  • Furthermore, GCTs could be regarded as lesions that reflect a local metabolic or reactive change rather than a true neoplasm.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Calbindin 2. Cell Nucleus / pathology. Cell Shape. Child. Female. Humans. Immunohistochemistry. Inhibins / analysis. Macrophages / pathology. Male. Membrane Glycoproteins. Middle Aged. Nerve Tissue Proteins / analysis. Receptors, Nerve Growth Factor / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Tongue Neoplasms / pathology. Ubiquitin Thiolesterase / analysis. Vimentin / analysis. Young Adult. gp100 Melanoma Antigen

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  • (PMID = 19192059.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / CD68 antigen, human; 0 / Calbindin 2; 0 / Membrane Glycoproteins; 0 / NGFR protein, human; 0 / Nerve Tissue Proteins; 0 / PMEL protein, human; 0 / Receptors, Nerve Growth Factor; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; 0 / gp100 Melanoma Antigen; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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55. Sidwell RU, Rouse P, Owen RA, Green JS: Granular cell tumor of the scrotum in a child with Noonan syndrome. Pediatr Dermatol; 2008 May-Jun;25(3):341-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the scrotum in a child with Noonan syndrome.
  • Granular cell tumor is a rare neoplasm thought to be of neural origin, composed of cells with distinctive granular cytoplasm.
  • Granular cell tumors most often arise on the tongue, but can occur at any body site, and therefore initial presentation to dermatologists is common.
  • We report a granular cell tumor of the scrotum in a child with Noonan syndrome, known to have a mutation in the PTPN11 gene.
  • No previous reports of granular cell tumor of the scrotum in a child are found.
  • The tumor is usually benign; however, it can have a high local recurrence rate (variable between 2% and 50% dependent on whether initial excision is complete and on the occurrence of an infiltrative growth pattern) and therefore long-term follow-up is necessary.
  • This case highlights the occurrence of granular cell tumor, a diagnosis not to be missed by the dermatologist.
  • In addition, we postulate the possible role of PTPN11 mutations in the development of granular cell tumor.
  • [MeSH-major] Genital Neoplasms, Male / genetics. Granular Cell Tumor / genetics. Mutation. Noonan Syndrome / complications. Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics

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  • (PMID = 18577039.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11
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56. Hatta J, Yanagihara M, Hasei M, Abe S, Tanabe H, Mochizuki T: Case of multiple cutaneous granular cell tumors. J Dermatol; 2009 Sep;36(9):504-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case of multiple cutaneous granular cell tumors.
  • Granular cell tumor is an uncommon, benign tumor, which mainly occurs on the skin, tongue and oral cavity as a single nodule.
  • Multiple granular cell tumors are rare, with the incidence reported to vary from 7-29% in adult cases of the tumor.
  • We describe a case of multiple cutaneous granular cell tumors in the right lumber and back regions along with a brief review of the published work on multiple cutaneous granular cell tumors.
  • [MeSH-major] Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 19712278.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 9007-34-5 / Collagen
  • [Number-of-references] 25
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57. Zagólski O, Gajda M, Czajecki K: [Granular cell tumor of the larynx--literature review and case report]. Przegl Lek; 2007;64(9):598-600

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the larynx--literature review and case report].
  • Granular cell tumor (Abrikosov's tumor) of the larynx is a very uncommon lesion.
  • The exact origin of granular cell tumor is still unclear, however most authors believe it to be a neoplastic process derived from neuroectoderm.
  • No tumor was observed.
  • Applying Kleinsasser procedure, a tumor 3 mm in diameter covered with normal mucosa was found growing in the posterior wall of the bottom of the right ventricle.
  • The tumor as well as hypertrophic mucosa of the vocal folds were removed.
  • Histopathological examination of the operative specimen revealed a granular cell tumor and chronic laryngitis.
  • Immunohistochemically tumor cells were positive for S-100.
  • CONCLUSION: Surgical removal of the laryngeal granular cell tumor with indications and extent of the resection like in benign tumors, was therapeutically efficient in the presented case.
  • [MeSH-major] Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery

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  • (PMID = 18510083.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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58. Newman E, Eichenfield LF: Granular cell tumor on the palm of an 8-year-old girl. Pediatr Dermatol; 2010 Nov-Dec;27(6):656-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor on the palm of an 8-year-old girl.
  • Granular cell tumors are rare benign peripheral nerve neoplasms that are most commonly reported on the tongue and oral mucosa.
  • We report a child with a granular cell tumor of the palm that required removal by an orthopedic hand surgeon.
  • [MeSH-major] Granular Cell Tumor / pathology. Hand. Peripheral Nervous System Neoplasms / pathology

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  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 21510018.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Mindea SA, Kaplan KJ, Howard MA, O'Leary ST: Granular cell tumor involving the axillary nerve: an unusual occurrence. Case report. Neurosurg Focus; 2007;22(6):E24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor involving the axillary nerve: an unusual occurrence. Case report.
  • Granular cell tumors (GCTs) are benign lesions that, paradoxically, despite originating from the Schwann cell, are most commonly seen in nonneuronal tissue including the skin, subcutaneous tissue, and tongue.
  • [MeSH-major] Axilla / innervation. Granular Cell Tumor / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / radiography

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  • (PMID = 17613216.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Perçinel S, Savaş B, Yilmaz G, Erinanç H, Küpana Ayva S, Bektaş M, Ensari A: Granular cell tumor of the esophagus: three case reports and review of the literature. Turk J Gastroenterol; 2008 Sep;19(3):184-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the esophagus: three case reports and review of the literature.
  • The esophagus is the most common site of origin of gastrointestinal tract granular cell tumors.
  • Approximately 270 cases of esophageal granular cell tumors have been reported in the literature.
  • Most esophageal granular cell tumors are found incidentally during endoscopy.
  • Although granular cell tumor of the esophagus has become easily recognizable by its endoscopic features, it has to be differentiated from other benign and malignant mucosal and submucosal lesions.
  • The majority of esophageal granular cell tumors are asymptomatic and benign; thus, close follow-up of the patients with endoscopy could be considered sufficient as a therapeutic management.
  • Three cases of granular cell tumors with complaints of epigastric discomfort, regurgitation, nausea, and vomiting, which were detected in the lower part of the esophagus on upper gastrointestinal tract endoscopy, are discussed with the most recent literature review on this subject.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 19115155.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 53
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61. Meyer MA, Becker JM, Quinones W: Endobronchial granular cell tumor: a case report. J Radiol Case Rep; 2010;4(8):29-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endobronchial granular cell tumor: a case report.
  • Granular cell tumors (GCTs) are benign neoplasms that are most commonly found in the head and neck region.
  • We present a case of endobronchial granular cell tumor presenting as hemoptysis in a 22-year-old African American female.

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  • (PMID = 22470750.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303395
  • [Keywords] NOTNLM ; Granular cell tumor / endobronchial
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62. Abu-Eid R, Landini G: Morphometrical differences between pseudo-epitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas. Histopathology; 2006 Mar;48(4):407-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphometrical differences between pseudo-epitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas.
  • AIM: Granular cell tumour (GCT) is a benign tumour which occasionally induces pseudo-epitheliomatous hyperplasia (PEH) of the covering epithelium, mimicking squamous cell carcinoma (SCC) invasion.
  • The cell-wise discrimination between the two entities using cellular morphology was 76% but when the two approaches were combined, the correct discrimination was 96%.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Granular Cell Tumor / pathology. Mouth Neoplasms / pathology

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  • (PMID = 16487362.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Storck C, Savic S, Egli J, Fischer C, Wolfensberger M: [Granular cell tumor of the larynx: a case report]. HNO; 2008 Dec;56(12):1229-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the larynx: a case report].
  • Granular cell tumors are benign subcutaneous or submucosal lesions of neurogenic origin.
  • However, only about 200 cases of laryngeal granular cell tumors have been reported so far.
  • Most laryngeal granular cell tumors are located in the posterior part of the vocal fold and in the posterior commissure.
  • However, tumor extension and expected morbidity of the surgery will inevitably influence the extent of the resection.

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  • [Cites] J Otolaryngol. 1992 Dec;21(6):450-3 [1494192.001]
  • [Cites] Laryngoscope. 1988 Aug;98(8 Pt 1):810-4 [2456439.001]
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  • (PMID = 18340420.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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64. Stock D, McKee P, Donley B, Lakin R, Goldblum J, Howard M: Granular cell tumor of the toe: a case report. J Foot Ankle Surg; 2009 May-Jun;48(3):358-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the toe: a case report.
  • The authors present a case of a granular cell tumor of the second digit that was treated with a partial digit amputation.
  • Radiographs, magnetic resonance images, and, finally, ultrasound images were used to confirm the presence of an underlying mass, and biopsy confirmed the diagnosis of granular cell tumor.
  • We feel that it is important for surgeons to maintain a high index of suspicion, particularly when a seemingly benign lesion, such as a hyperkeratosis, fails to respond as expected to treatment.
  • [MeSH-major] Granular Cell Tumor / pathology. Soft Tissue Neoplasms / pathology. Toes / pathology

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  • (PMID = 19423037.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Xue JL, Fan MW, Wang SZ, Chen XM, Li Y: [A clinicopathological study of 14 cases of oral granular cell tumor]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jul;40(4):302-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A clinicopathological study of 14 cases of oral granular cell tumor].
  • OBJECTIVE: To describe clinical and histological features of oral granular cell tumor (OGCT)and discuss their proliferative activity.
  • Histologically, the lesions consisted of polygonal cells with abundant, granular cytoplasm.
  • Immunohistochemical analysis disclosed that 100% of granular cells demonstrated moderated/strong staining for S-100 protein, neuron specific enolase (NSE).
  • Nuclear immunostaining for Ki-67 was observed only in isolated granular cells.
  • Seven patients with benign and two patients with atypical granular cell tumor had no recurrence and metastases.
  • One patient with atypical granular cell tumor had local recurrence after 9 years and died of the disease 10 months later.
  • Most OGCTs are benign but few have malignant potential and periodic follow-up is mandatory to detect malignant transformation.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology

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  • (PMID = 16191373.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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66. Lauwers K, Bestman TJ, Bergmans G, Molderez C: Granular cell tumour of the male breast. Acta Chir Belg; 2008 Jan-Feb;108(1):112-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumour of the male breast.
  • Granular cell tumour (GCT) is a rare neoplasm that can be found in multiple sites throughout the body.
  • In general, it appears as a singular benign lesion, although it can be multi-focal and rare cases with malignant behaviour have been reported.
  • We report a rare case of granular cell tumour of the nipple in the male breast, treated by wide local excision.
  • [MeSH-major] Breast Neoplasms, Male / surgery. Granular Cell Tumor / surgery

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  • (PMID = 18411585.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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67. Silva GC, Vieira TC, Vieira JC, Martins CR, Silva EC: Congenital granular cell tumor (congenital epulis): a lesion of multidisciplinary interest. Med Oral Patol Oral Cir Bucal; 2007 Oct;12(6):E428-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital granular cell tumor (congenital epulis): a lesion of multidisciplinary interest.
  • Congenital granular cell tumor (CGCT), or congenital epulis, is a very uncommon benign soft tissue lesion that usually arises from the alveolar mucosa of neonates and may cause respiratory and feeding problems.
  • We report a case of a 3-day-old female newborn, who presented an intraoral tumor mass which was protruding from her mouth, and compromising feeding.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital

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  • (PMID = 17909507.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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68. Mnasri H, Bouchoucha S: Granular cell tumour of the perianal region: which therapeutic attitude? Acta Chir Belg; 2005 Feb;105(1):112-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumour of the perianal region: which therapeutic attitude?
  • Granular cell tumours are uncommon soft tissue tumours that could be located anywhere throughout the body.
  • Most of time they are benign but the diagnosis of malignancy is difficult to establish on histology: this is why the therapeutic decision is not easy to take in particular for some locations.
  • We report the case of a 18-year old man: he presented, in the perianal region, a granular cell tumour of uncertain malignant potential (so far the first case described in the literature) for which we decided a conservative surgical treatment that failed.
  • [MeSH-major] Anus Neoplasms / surgery. Granular Cell Tumor / surgery

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  • (PMID = 15790218.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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69. Abraham T, Jackson B, Davis L, Yu J, Peterson C: Mohs surgical treatment of a granular cell tumor on the toe of a child. Pediatr Dermatol; 2007 May-Jun;24(3):235-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs surgical treatment of a granular cell tumor on the toe of a child.
  • Granular cell tumors are uncommon, usually benign tumors of neural origin.
  • We report a granular cell tumor on the distal toe of a 5-year-old child, removed with Mohs surgery.
  • Review of the English language literature revealed four previously reported granular cell tumors treated with Mohs micrographic surgery, none of which was in a child.
  • [MeSH-major] Granular Cell Tumor / surgery. Mohs Surgery. Skin Neoplasms / surgery. Toes / surgery

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  • (PMID = 17542870.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Mesquita AT, Santos CR, Gomez RS, Jorge J, León JE, de Almeida OP: Central granular cell odontogenic tumor: a histopathologic and immunohistochemical study. Ann Diagn Pathol; 2009 Dec;13(6):405-12
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  • [Title] Central granular cell odontogenic tumor: a histopathologic and immunohistochemical study.
  • The central granular cell odontogenic tumor (CGCOT) is a rare lesion that usually affects the posterior region of the mandible of young adults.
  • The granular cells were positive for vimentin, CD68, lysozyme, muscle-specific actin, alpha-smooth muscle actin, calponin, neuron-specific enolase (NSE), CD138, and bcl-2.
  • Dendritic-like cells surrounding the OE displayed positivity for vimentin, CD1a, S100, CD68, and bcl-2, but it was negative for factor XIIIa, supporting a Langerhans cell phenotype.
  • These data confirm the benign nature of CGCOT, the association of OE with Langerhans cells, and a variable phenotype of the granular cells.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Granular Cell Tumor / metabolism. Mandibular Neoplasms / metabolism. Odontogenic Tumors / metabolism

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  • (PMID = 19917479.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Messina M, Severi FM, Buonocore G, Molinaro F, Amato G, Petraglia F: Prenatal diagnosis and multidisciplinary approach to the congenital gingival granular cell tumor. J Pediatr Surg; 2006 Oct;41(10):E35-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal diagnosis and multidisciplinary approach to the congenital gingival granular cell tumor.
  • OBJECTIVE: Congenital gingival granular cell tumor (CGCT) is a rare benign lesion appearing at birth on the alveolar median ridge of the maxilla.
  • Pathology revealed a tumor of large polyedric cells with vacuolar central nuclei and eosinophil granular cytoplasm.
  • [MeSH-major] Gingival Neoplasms / surgery. Gingival Neoplasms / ultrasonography. Granular Cell Tumor / surgery. Granular Cell Tumor / ultrasonography. Patient Care Team. Ultrasonography, Prenatal

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  • (PMID = 17011257.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Saint-Blancard P, Pierre B, Philippe C, de Soultrait FR: [A rare case of diminished visual acuity: neurohypophyseal granular cell tumor]. Neurochirurgie; 2007 Aug;53(4):296-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare case of diminished visual acuity: neurohypophyseal granular cell tumor].
  • A neurohypophyseal granular cell tumor was found in a 60-year-old man who presented diminished visual acuity.
  • Granulous cell tumors, which are common, are rarely located in the neurohypophysis.
  • Their origin remains a subject of debate, but unlike the other localizations, these tumors in the sellar and/or supra-sellar area are always considered benign.
  • [MeSH-major] Granular Cell Tumor / physiopathology. Pituitary Diseases / physiopathology. Pituitary Neoplasms / physiopathology. Vision Disorders / physiopathology. Visual Acuity / physiology

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  • (PMID = 17585953.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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73. Narra SL, Tombazzi C, Datta V, Ismail MK: Granular cell tumor of the esophagus: report of five cases and review of the literature. Am J Med Sci; 2008 May;335(5):338-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the esophagus: report of five cases and review of the literature.
  • Granular cell tumor (GCT) is an uncommon esophageal neoplasm.
  • The usual course of GCTs is benign.
  • [MeSH-major] Esophageal Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 18480648.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Abo-Hager EA, Khater DS, Ahmed MM: Exploration of the histogenesis of congenital granular cell epulis: an immunohistochemical study. J Egypt Natl Canc Inst; 2009 Jun;21(2):77-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exploration of the histogenesis of congenital granular cell epulis: an immunohistochemical study.
  • OBJECTIVE: Congenital granular cell epulis is a benign soft tissue lesion of the neonate that arises from the alveolar ridges of the jaws in newborns.
  • The aim of this study is to define the histogenesis of congenital granular cell epulis by using several immunohistochemical markers.
  • MATERIALS AND METHODS: A series of six cases of congenital granular cell epulis were immunostained with a panel of antibodies (NSE, CD68, CD99, Mesothelin, Inhibin-a, GFAP, Dystrophin, NGFR/p75 and TLR1).
  • RESULTS: Granular cells of all cases showed positive cytoplasmic immunostaining for NSE and CD68.
  • Granular and interstitial cells in all cases were negative with the remaining antibodies.
  • The immunoreactivity of the granular cells to NSE showed the statistically significantly highest mean area percent.
  • CONCLUSION: The expression of NSE and CD99 in all cases of the present study support a neuroectodermal derivation of congenital granular cell epulis.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gingival Neoplasms / metabolism. Gingival Neoplasms / pathology. Granular Cell Tumor / metabolism. Granular Cell Tumor / pathology

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  • (PMID = 21057558.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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75. Lowe DL, Chaudhary AJ, Lee JR, Chamberlain SM, Schade RR, Cuartas-Hoyos U: Four cases of patients with gastrointestinal granular cell tumors. South Med J; 2007 Mar;100(3):298-300
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  • [Title] Four cases of patients with gastrointestinal granular cell tumors.
  • We present four cases of gastrointestinal granular cell tumors (GCT) with a literature review.
  • Gastrointestinal granular cell tumors, a benign neural tumor thought to arise from Schwann cells, can occur in several areas, including the gastrointestinal tract.
  • Although most GCTs are benign and can be followed endoscopically without resection, the malignant potential warrants evaluation with endoscopic ultrasound for possible endoscopic or surgical resection.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Esophageal Neoplasms / diagnosis. Granular Cell Tumor / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 17396735.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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76. Sargenti-Neto S, Brazão-Silva MT, do Nascimento Souza KC, de Faria PR, Durighetto-Júnior AF, Loyola AM, Cardoso SV: Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions. Br J Oral Maxillofac Surg; 2009 Jan;47(1):62-4
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  • [Title] Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions.
  • Granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue that characteristically affects the oral cavity, with increased frequency in the tongue.
  • [MeSH-major] Granular Cell Tumor / pathology. Lip Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Genital Neoplasms, Female / surgery. Humans. Neoplasm Recurrence, Local. Perineum / pathology. Perineum / surgery

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  • (PMID = 18976838.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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77. Di Cicilia R, Castellucci P, Nannini M, Balbi T, Zannetti G, Fanti S, Biasco G, Pantaleo MA: Unusual finding of benign Abrikossoff tumor by F-18 FDG-PET mimicking melanoma recurrence. Clin Nucl Med; 2009 Oct;34(10):696-7
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  • [Title] Unusual finding of benign Abrikossoff tumor by F-18 FDG-PET mimicking melanoma recurrence.
  • Granular cell tumor of Abrikossoff is a rare neoplasm that may occur in a wide variety of cutaneous and visceral sites.
  • Granular cell tumor generally shows benign behavior.
  • We present a case of F-18 fluorodeoxyglucose positron emission tomography in Abrikossoff tumor, suggesting that F-18 fluorodeoxyglucose positron emission tomography may have a potential role in the management of this neoplasm.
  • [MeSH-major] Fluorodeoxyglucose F18. Granular Cell Tumor / radionuclide imaging. Melanoma / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 19893405.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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78. Singhi AD, Montgomery EA: Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol; 2010 Aug;34(8):1186-92
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  • [Title] Colorectal granular cell tumor: a clinicopathologic study of 26 cases.
  • Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA).
  • Although GCTs were benign tumors in this series, if incompletely excised regrowth of the lesion may occur and therefore, follow-up may be warranted.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Colectomy. Colonoscopy. Female. Humans. Immunohistochemistry. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. S100 Proteins / analysis

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  • (PMID = 20661017.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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79. Aneiros-Fernandez J, Arias-Santiago S, Husein-Elahmed H, Ovalle F, Siendones MI, Aneiros-Cachaza J: Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall. J Clin Med Res; 2010 Aug 18;2(4):185-8

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  • [Title] Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall.
  • We report the clinical-morphological study of a granular cell tumor in dermal/hypodermal junction and subcutaneous fat left breast of an 83-year-old woman with a family history of breast carcinoma.
  • The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors.
  • We present a benign lesion that clinically reproduces a breast carcinoma.
  • KEYWORDS: Granular cell tumor; Breast; Differential diagnosis; Cutaneous.

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  • [Cites] J Magn Reson Imaging. 1999 Feb;9(2):187-96 [10077012.001]
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  • (PMID = 21629537.001).
  • [ISSN] 1918-3011
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3104657
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80. Mátrai Z, Langmár Z, Szabó E, Rényi-Vámos F, Bartal A, Orosz Z, Németh M, Tóth L: Granular cell tumour of the breast: case series and review of the literature. Eur J Gynaecol Oncol; 2010;31(6):636-40
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  • [Title] Granular cell tumour of the breast: case series and review of the literature.
  • Granular cell tumours (GCTs) are uncommon rare neoplasms that may occur in any part of the body.
  • Approximately 5-8% of granular cell tumours occur within the breast.
  • Although nearly always benign in behaviour, granular cell tumours of the breast can often mimic breast malignancies both clinically and on the basis of imaging techniques.
  • This article reports five cases of benign granular cell tumours appearing in the breast, mimicking a malignant breast lesion.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Granular Cell Tumor / diagnosis. Granular Cell Tumor / pathology

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  • (PMID = 21319506.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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81. Popovska S: [Granular cell tumor of the breast--review of the literature and research for a period of 5 years]. Khirurgiia (Sofiia); 2006;(1):53-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the breast--review of the literature and research for a period of 5 years].
  • Granular cell tumor is relatively rare neoplasm, and always benign in its prognostic behavior.
  • Location of this tumor in the breast presents serious problems for differential diagnosis, both from a clinical point of view and at gross pathologic examination, because of its resemblance to carcinoma.
  • Most granular cell tumors appear to be derived from Schwann cells of peripheral nerves, but many different lesions in the breast show granular cell changes.
  • The authors describe four typical cases of breast granular cell tumors that occurred in patients of different ages, and discuss the most important problems concerning this lesion.
  • [MeSH-major] Breast Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 18771140.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Bulgaria
  • [Number-of-references] 11
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82. Nagaraj PB, Ongole R, Bhujanga-Rao BR: Granular cell tumor of the tongue in a 6-year-old girl--a case report. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E162-4

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  • [Title] Granular cell tumor of the tongue in a 6-year-old girl--a case report.
  • Granular cell tumor is a relatively uncommon benign hamartomatous lesion occurring in almost any part of the body.
  • Granular cell lesions may be found in other diverse sites such as the jaw, skin, gastro intestinal tract and respiratory tract.
  • The tumor generally occurs in middle or older aged adults.
  • As most of the granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • We describe a case of granular cell tumor of the tongue in a 6 year old girl along with a brief review of literature on granular cell tumors.
  • [MeSH-major] Granular Cell Tumor. Tongue Neoplasms

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  • (PMID = 16505796.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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83. Laco J: [Congenital granular cell epulis: a case report]. Cesk Patol; 2009 Oct;45(4):117-9
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  • [Title] [Congenital granular cell epulis: a case report].
  • Congenital granular cell epulis is a rare benign lesion occuring exclusively in newborns as a solitary or multiple swelling of alveolar mucosa of either maxilla or mandible.
  • On 24th postnatal day, the lesions were under general anesthesia excised and sent for microscopic examination, which revealed congenital granular cell epulis.
  • Immunohistochemically, granular cells showed expression of both vimentin and PGP 9.5, whereas the proof of S100 protein and inhibin was negative.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital

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  • (PMID = 20301840.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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84. Miyake M, Tateishi U, Maeda T, Arai Y, Hasegawa T, Sugimura K: Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT. Radiat Med; 2006 Feb;24(2):154-7

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  • [Title] Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT.
  • Bronchial granular cell tumor is an uncommon benign tumor that causes pulmonary complications due to obstruction of the airways.
  • [MeSH-major] Bronchial Neoplasms / complications. Granular Cell Tumor / complications. Lung Diseases, Obstructive / etiology

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  • (PMID = 16715680.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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85. Caltabiano R, Cappellani A, Di Vita M, Lanzafame S: The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. J Craniofac Surg; 2008 Nov;19(6):1691-4
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  • [Title] The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study.
  • We report a case of a 47-year-old man with a granular cell tumor (GCT) of the tongue colocalized with a squamous cell carcinoma.
  • Furthermore, we performed an immunohistochemical analysis with p63 to distinguish pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma.
  • Clinicians and pathologists must be made aware of this potential diagnostic pitfall so that the workup of a tongue lesion does not end prematurely with a benign diagnosis of granular cell tumor with overlying pseudoepitheliomatous hyperplasia.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Epithelium / pathology. Follow-Up Studies. Humans. Hyperplasia. Immunohistochemistry. Male. Membrane Proteins / analysis. Middle Aged. Mouth Mucosa / pathology. Neoplasm Invasiveness. S100 Proteins / analysis

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  • (PMID = 19098584.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins
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86. Reuhl J, Fink T, Glees M, Bernd L, Fisseler-Eckhoff A: [An unusual complication after an insect bite? Diagnostic procedures in a case of granular cell tumor]. Pathologe; 2007 Jul;28(4):273-7
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  • [Title] [An unusual complication after an insect bite? Diagnostic procedures in a case of granular cell tumor].
  • Granular cell tumors are, in almost all cases, benign soft tissue tumors, although malignant variants have rarely been described in a variety of anatomical locations.
  • In the case presented here, a so-called atypical granular cell tumor was diagnosed based on two criteria, being differentiated from the usual histological findings by enhanced mitotic activity and focal spindle cell proliferation.
  • Further suspicious characters of the tumor were its size of 13x10x5 cm on MRT as well as its long-term clinical course (1.5 years).
  • The diagnostic procedures undergone until resection of the tumor, including the macroscopic and histological findings, are presented.
  • The tumor cells react positively with antibodies against S-100 protein, NSE, laminin, myelin proteins and myelin-associated glycoproteins.
  • These staining patterns underscore the neural origin of the tumor tissue.
  • In this case a mitotic frequency of two per ten high power fields and focal spindle cells led to the diagnosis of an atypical granular cell tumor, whereas the criteria for a malignant variant were not met.
  • [MeSH-major] Bites and Stings / complications. Bites and Stings / pathology. Granular Cell Tumor / pathology. Skin Neoplasms / pathology

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  • [Cites] Hum Pathol. 1996 Aug;27(8):853-8 [8760023.001]
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  • (PMID = 16555043.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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87. Kondo T, Kajimoto S, Okuda H, Toma H, Tanabe K: A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. Int J Urol; 2006 Jun;13(6):827-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery.
  • Granular cell tumor is a benign neoplasm which frequently occurs in the oral cavity, skin, and subcutaneous tissue.
  • Granular cell tumor of the bladder is an extremely rare disease, and only nine cases have been reported.
  • We present here an additional case of granular cell tumor occurring in the bladder.
  • Unlike the other tumors reported, this tumor extruded into the Retzius' cavity.
  • Therefore, the tumor was successfully excised through extraperitoneal laparoscopic surgery.
  • The small tumor located in Retzius' cavity could be managed with extraperitoneal laparoscopic surgery.
  • [MeSH-major] Granular Cell Tumor / therapy. Laparoscopy. Urinary Bladder Neoplasms / therapy

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  • (PMID = 16834673.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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88. Wright NA, Thomas CG, Calame A, Cockerell CJ: Granular cell atypical fibroxanthoma: case report and review of the literature. J Cutan Pathol; 2010 Mar;37(3):380-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell atypical fibroxanthoma: case report and review of the literature.
  • We present a case of granular cell atypical fibroxanthoma of the scalp.
  • The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man.
  • Histology demonstrated a diffuse proliferation of atypical epithelioid cells with abundant granular cytoplasm.
  • The granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarcoma protuberans, fibrous papules, basal cell carcinomas, leiomyosarcomas, angiosarcomas and primitive polypoid granular cell tumors.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor. Disease-Free Survival. Humans. Immunohistochemistry. Male. Scalp / metabolism. Scalp / pathology. Scalp / surgery. Treatment Outcome

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  • (PMID = 19341433.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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89. Abbas F, Memon A, Siddiqui T, Kayani N, Ahmad NA: Granular cell tumors of the urinary bladder. World J Surg Oncol; 2007;5:33
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  • [Title] Granular cell tumors of the urinary bladder.
  • BACKGROUND: Granular cell tumors (GCTs) are extremely rare lesions of the urinary bladder with only nine cases being reported in world literature of which one was malignant.
  • Generally believed to be of neural origin based on histochemical, immunohistochemical, and ultrastructural studies; they mostly follow a clinically benign course but are commonly mistaken for malignant tumors since they are solid looking, ulcerated tumors with ill-defined margins.
  • MATERIALS AND METHODS: We herein report two cases of GCTs, one benign and one malignant, presenting with gross hematuria in a 14- and a 47-year-old female, respectively.
  • The benign tumor was successfully managed conservatively with transurethral resection alone while for the malignant tumor, radical cystectomy, hysterectomy with bilateral salpingo-oophorectomy, anterior vaginectomy, plus lymph node dissection was done.
  • CONCLUSION: We recommend careful pathologic assessment for establishing the appropriate diagnosis and either a conservative or aggressive surgical treatment for benign or localized malignant GCT of the urinary bladder, respectively.
  • [MeSH-major] Cystoscopy / methods. Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Neoplasm Invasiveness / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biopsy, Needle. Emergency Service, Hospital. Female. Follow-Up Studies. Hematuria / diagnosis. Hematuria / etiology. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Nephrostomy, Percutaneous / methods. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17355632.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1828733
  • [General-notes] NLM/ Original DateCompleted: 20070810
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90. Ramaswamy PV, Storm CA, Filiano JJ, Dinulos JG: Multiple granular cell tumors in a child with Noonan syndrome. Pediatr Dermatol; 2010 Mar-Apr;27(2):209-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple granular cell tumors in a child with Noonan syndrome.
  • Granular cell tumors are benign neurally derived neoplasms, involving cutaneous and subcutaneous tissues; and typically occur as solitary lesions.
  • Multiple granular cell tumors occur in 10% of affected individuals, but are in children.
  • Children with underlying somatic and genetic syndromes, including neurofibromatosis and Noonan syndrome, appear to be at higher risk of developing multiple granular cell tumors.
  • Skin biopsy assists in diagnosis, since granular cell tumors have a similar appearance to other cutaneous nodules.
  • Painful or rapidly growing granular cell tumors should be excised and asymptomatic non-growing granular cell tumors may be observed.
  • Children with multiple granular cell tumors should have a complete physical examination to rule out an underlying genetic syndrome.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Neoplasms, Multiple Primary / diagnosis. Noonan Syndrome / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20537083.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11
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91. Porter GJ, Evans AJ, Lee AH, Hamilton LJ, James JJ: Unusual benign breast lesions. Clin Radiol; 2006 Jul;61(7):562-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual benign breast lesions.
  • The purpose of this article is to show examples of the radiological (mammography and/or ultrasound) and pathological appearances of unusual benign breast lesions.
  • The conditions covered are granular cell tumours, fibromatosis, nodular fasciitis, myofibroblastomas, haemangiomas, neurofibromas, and leiomyomas.
  • [MeSH-minor] Fasciitis / radiography. Fasciitis / ultrasonography. Female. Fibroma / radiography. Fibroma / ultrasonography. Granular Cell Tumor / radiography. Granular Cell Tumor / ultrasonography. Hemangioma / radiography. Hemangioma / ultrasonography. Humans. Leiomyoma / radiography. Leiomyoma / ultrasonography. Mammography / methods. Neoplasms, Muscle Tissue / radiography. Neoplasms, Muscle Tissue / ultrasonography. Neurofibroma / radiography. Neurofibroma / ultrasonography. Ultrasonography, Mammary / methods

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  • (PMID = 16784941.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 26
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92. Chaudhry IH, Calonje E: Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases. Histopathology; 2005 Aug;47(2):179-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases.
  • AIMS: Cutaneous and soft tissue granular cell tumour is a well-characterized benign neoplasm of neural origin.
  • However, there remains a subcategory of granular cell tumour, first described by Le Boit as 'primitive polypoid granular cell tumour', that shows no obvious line of differentiation.
  • METHODS AND RESULTS: Eleven cases of dermal non-neural granular cell tumour were retrieved from one of the authors referral archives (E.C.) and both the histology and immunohistochemistry reviewed.
  • The tumours were composed of elongated spindle-shaped to polygonal or round cells with prominent granular cell change, and tumour nuclei showing mild focal atypia to rare moderate atypia.
  • [MeSH-major] Granular Cell Tumor / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Child. Factor XIIIa / analysis. Female. Humans. Immunohistochemistry. Lysosomes / immunology. Male. Middle Aged

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  • (PMID = 16045779.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa
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93. Persaud R, Tudge S, Amonoo-Kuofi K, Beale T, O'Flynn P: Parapharyngeal granular cell tumour: a unique surgical challenge. J Laryngol Otol; 2005 Jan;119(1):68-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parapharyngeal granular cell tumour: a unique surgical challenge.
  • A granular cell tumour is a rare lesion of probable nerve sheath origin.
  • It is typically benign but up to seven per cent may be malignant.
  • The authors report a case of a 49-year-old African woman with an oro-naso-parapharyngeal granular cell neoplasm causing mild dysphagia.
  • [MeSH-major] Granular Cell Tumor / surgery. Pharyngeal Neoplasms / surgery

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  • (PMID = 15807973.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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94. Kent M, d'Amato T, Nordman C, Schuchert M, Landreneau R, Alvelo-Rivera M, Luketich J: Minimally invasive resection of benign esophageal tumors. J Thorac Cardiovasc Surg; 2007 Jul;134(1):176-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive resection of benign esophageal tumors.
  • OBJECTIVE: Benign tumors of the esophagus are uncommon.
  • METHODS: A retrospective review of patients who underwent resection of benign esophageal tumors between 1990 and 2005 was conducted.
  • Operative approach, tumor size, and outcomes after surgery were recorded.
  • RESULTS: Twenty patients were identified (leiomyoma: n = 15; stromal tumor: n = 3; granular cell tumor, n = 1; schwannoma: n = 1).
  • Mean tumor size in the open group was 8.1 cm (range 7-10 cm) compared with 3.5 cm (range 0.9-8 cm) in the minimally invasive group.
  • Five patients subsequently required fundoplication for worsening (n = 3) or new-onset (n = 2) gastroesophageal reflux disease after tumor resection.
  • CONCLUSIONS: Minimally invasive resection of benign esophageal tumors is technically safe and associated with a shorter length of stay compared with open approaches.
  • [MeSH-major] Esophageal Neoplasms / surgery. Granular Cell Tumor / surgery. Laparoscopy / methods. Leiomyoma / surgery. Neurilemmoma / surgery. Thoracoscopy / methods

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  • (PMID = 17599505.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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95. Scaranelo AM, Bukhanov K, Crystal P, Mulligan AM, O'Malley FP: Granular cell tumour of the breast: MRI findings and review of the literature. Br J Radiol; 2007 Dec;80(960):970-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumour of the breast: MRI findings and review of the literature.
  • Granular cell tumours (GCTs) are uncommon, usually benign neoplasms that can mimic malignancy on breast imaging.
  • We report a case of granular cell tumour of the breast presenting as a suspicious lesion on breast imaging, and review the MRI features of GCTs.
  • [MeSH-major] Breast Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 17940129.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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96. Scala WA, Fernandes AM, Duprat Ade C, Costa HO: Granular cell tumor of the larynx in children: a case report. Braz J Otorhinolaryngol; 2008 Sep-Oct;74(5):780-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the larynx in children: a case report.
  • The granular cell tumor (GCT) is an uncommon neoplasm, with slow progression, usually benign, that can be found in any organ.
  • Among the major theories of origin and based on the strongest evidence, the most accepted one is that the tumor stems from neuronal tissue.
  • [MeSH-major] Granular Cell Tumor / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 19082363.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 13
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97. Lerman M, Freedman PD: Nonneural granular cell tumor of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar;103(3):382-4
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  • [Title] Nonneural granular cell tumor of the oral cavity: a case report and review of the literature.
  • Nonneural granular cell tumors (NNGCTs) are rare benign neoplasms originally described in 1991 by Leboit et al.
  • Typical granular cell tumors (GCTs) are commonly encountered in the oral cavity, but NNGCTs, unlike GCTs, are S-100 negative and may display cytologic atypia, allowing for misdiagnosis as a more aggressive lesion.
  • [MeSH-major] Granular Cell Tumor / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17321450.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD63 protein, human; 0 / CD68 antigen, human; 0 / Platelet Membrane Glycoproteins
  • [Number-of-references] 9
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98. Lochan R, Balupuri S, Bennett MK, Manas DM: Granular cell tumor as an unusual cause of obstruction at the hepatic hilum: report of a case. Surg Today; 2006;36(10):934-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor as an unusual cause of obstruction at the hepatic hilum: report of a case.
  • Although benign tumors occasionally develop in this location, preoperative recognition is difficult and most are treated as malignant lesions.
  • We illustrate this clinical scenario in this case report of a granular cell tumor (GCT) that developed at the biliary bifurcation, necessitating right hemi-hepatectomy with extrahepatic biliary tree excision.
  • We describe the clinical presentation, imaging findings, treatment, and histological findings of this tumor.
  • However, the possibility of this tumor should be considered in the differential diagnosis of a lesion in this location.
  • [MeSH-major] Bile Duct Neoplasms / complications. Cholestasis, Extrahepatic / etiology. Granular Cell Tumor / complications. Hepatic Duct, Common

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99. Patti R, Almasio PL, Di Vita G: Granular cell tumor of stomach: a case report and review of literature. World J Gastroenterol; 2006 Jun 7;12(21):3442-5
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of stomach: a case report and review of literature.
  • Granular cell tumor (GCT) was described for the first time by Abrikosoff in 1926.
  • It is a relatively rare neoplasm that may occur at many sites, but most commonly in the skin or soft tissues.
  • Although GCTs are usually clinically and histologically benign, some malignant cases have been reported.
  • A correct preoperative diagnosis of this tumor can only be made in 50% of all patients and it is always based on endoscopic biopsy.
  • In this study, the authors reported a case of a 49-year-old woman with a solitary granular cell tumor of the stomach with infiltrative pattern, successfully treated with surgical resection.
  • [MeSH-major] Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 16733867.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 17
  • [Other-IDs] NLM/ PMC4087881
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100. Hong R, Lim SC: Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report. World J Gastroenterol; 2009 Jul 14;15(26):3315-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report.
  • A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.
  • In addition to the tumor, endoscopic examination revealed the presence of a 5-mm-polyp in the descending colon and multiple tiny polyps in the sigmoid colon and rectum.
  • Histological examination demonstrated a cecal tumor 1.5 cm x 1.0 cm x 0.7 cm with a hard consistency; in cut sections, mixed cells with yellowish and whitish portions were seen.
  • The tumor was located between the mucosa and subserosa, and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm, which were immunoreactive for S-100 protein, vimentin, neuron-specific enolase, inhibin-alpha and calretinin.
  • The tumor showed extensive hyalinization and focal dystrophic calcification.
  • Immunohistochemical profiles did not confirm any particular cell type for the histogenetic origin of the GCT, including a nerve sheath origin.
  • Extensive hyalinization and calcification showing involution of tumor cells suggest benign clinical behavior of GCT.
  • [MeSH-major] Calcinosis / pathology. Cecum / pathology. Granular Cell Tumor / pathology. Hyalin / metabolism
  • [MeSH-minor] Biomarkers, Tumor. Calbindin 2. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / pathology. Humans. Male. Middle Aged. Phosphopyruvate Hydratase. S100 Calcium Binding Protein G. S100 Proteins. Vimentin

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  • (PMID = 19598311.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Other-IDs] NLM/ PMC2710791
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