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1. Chelly I, Bellil K, Mekni A, Bellil S, Belhadjsalah M, Kchir N, Haouet S, Zitouna MM: Malignant granular cell tumor of the abdominal wall. Pathologica; 2005 Jun;97(3):130-2
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  • [Title] Malignant granular cell tumor of the abdominal wall.
  • The granular cell tumor is an uncommon tumor that usually appears as a solitary small nodular growth and runs a benign course.
  • The authors report a case of malignant granular cell tumor which was arising in anterior abdominal wall of a 67-year-old woman.
  • [MeSH-major] Abdominal Neoplasms / pathology. Abdominal Wall / pathology. Granular Cell Tumor / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Fatal Outcome. Female. Humans. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Postoperative Complications. Pulmonary Embolism / complications

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  • (PMID = 16259279.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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2. Lucendo AJ, De Rezende L, Martín-Plaza J, Larrauri J: Esophageal granular cell tumor and eosinophilic esophagitis: two interesting entities identified in the same patient. Case Rep Gastroenterol; 2008;2(1):33-9
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  • [Title] Esophageal granular cell tumor and eosinophilic esophagitis: two interesting entities identified in the same patient.
  • Endoscopy detected a submucosal tumor in the upper third of the esophagus, which was typified, via biopsy, as a granular cell tumor with benign characteristics and probably responsible for the symptoms.
  • This is the first documented case of the link between granular cell tumors and Eosinophilic esophagitis, two different disorders which could cause dysphagia in young patients.

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  • (PMID = 21490835.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075163
  • [Keywords] NOTNLM ; Dysphagia / Eosinophilic esophagitis / Esophagus / Granular cell tumors
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3. K C S, Kouzu T, Hishikawa E: Multiple granular cell tumor of the esophagus treated endoscopically. JNMA J Nepal Med Assoc; 2007 Jan-Mar;46(165):40-3
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  • [Title] Multiple granular cell tumor of the esophagus treated endoscopically.
  • Granular cell tumor (GCT) of esophagus is a rare lesion, usually found incidentally during upper gastrointestinal endoscopic examination undertaken for another reasons.
  • The origin of this neoplasm is still unclear but no organ seems to be immune to this neoplasm.
  • Although most of the lesions are benign, few reports of malignant GCT, synchronous as well as metachronous, are also reported.

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  • (PMID = 17721562.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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4. Pertile D, Scabini S, Romairone E, Scordamaglia R, Rimini E, Ferrando V: Gastric Abrikosoff tumor (granular cell tumor): case report. G Chir; 2010 Oct;31(10):433-4
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  • [Title] Gastric Abrikosoff tumor (granular cell tumor): case report.
  • Granular Cells Tumor (GCT), also called Abrikosoff tumor, is very uncommon lesion of neural derivation.
  • It is characterized by the presence of granular cell; benign and malignamt counterparts are known, even if the second ones are rare.
  • Surgical en-block excision is curative for both benign an malignant forms.
  • We report the case of a 45 year old man who had a cytologic diagnosis of fusocellular stromal tumor of the gastric fundus during examination for gastritis.
  • He underwent a wedge resection of the gastric wall: at the histological examination neoplastic cells had a granular cytoplasm and immunoassay was positive for S100 protein, PGP 9.5 and NSE.
  • [MeSH-major] Granular Cell Tumor. Stomach Neoplasms

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  • (PMID = 20939949.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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5. Agaimy A, Märkl B, Kitz J, Wünsch PH, Arnholdt H, Füzesi L, Hartmann A, Chetty R: Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants. Virchows Arch; 2010 Apr;456(4):411-22
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  • Granular cell tumors (GCTs; n = 31) and schwannomas (n = 22) were the most common types of PNSTs encountered.
  • In conclusion, PNSTs of the GI tract are rare uniformly benign neoplasms that may show schwannian, perineurial, fibroblastic, or mixed differentiation.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Granular Cell Tumor / diagnosis. Granular Cell Tumor / epidemiology. Granular Cell Tumor / pathology. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Young Adult

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  • (PMID = 20155280.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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6. Veit AC, Painter JT, Miller RA, Hardisty JF, Dixon D: Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study. Vet Pathol; 2008 Sep;45(5):654-62
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  • [Title] Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study.
  • The granular cell tumor is most often a benign neoplasm of uncertain origin.
  • Four uterine granular cell tumors in control and treated female B6C3F1 mice were identified in chronic studies at the National Toxicology Program.
  • The main histomorphologic feature of tumor cells was the presence of abundant cytoplasmic eosinophilic granules that stained positive for periodic acid-Schiff with diastase resistance.
  • The characteristics of these uterine granular cell tumors were suggestive of a myogenic origin.
  • [MeSH-major] Granular Cell Tumor / veterinary. Uterine Neoplasms / veterinary

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  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
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  • (PMID = 18725470.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS103826; NLM/ PMC2691646
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7. Pino Rivero V, Marcos García M, Rejas Ugena E, Trinidad Ruiz G, Pardo Romero G, González Palomino A, Gómez de Tejada Romero R, Blasco Huelva A: [Granular cell tumor of the tongue (Abrikossoff's tumor). Report of a case and review of the literature]. An Otorrinolaringol Ibero Am; 2005;32(1):65-70
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  • [Title] [Granular cell tumor of the tongue (Abrikossoff's tumor). Report of a case and review of the literature].
  • [Transliterated title] Tumor de células granulares lingual (tumor de Abrikossoff). Presentación de un caso y revisión de la literatura.
  • Granular cell tumor, myoblastoma or Abrikossoff's tumor is an uncommon benign lesion, usually of slow-growing, that shows a predilection for the oral cavity, especially the tongue.
  • Its real etiopathogenia remains still controversial and in it's histogenesis have been implicated several cell types.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 15803921.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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8. Hatta J, Yanagihara M, Hasei M, Abe S, Tanabe H, Mochizuki T: Case of multiple cutaneous granular cell tumors. J Dermatol; 2009 Sep;36(9):504-7
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  • [Title] Case of multiple cutaneous granular cell tumors.
  • Granular cell tumor is an uncommon, benign tumor, which mainly occurs on the skin, tongue and oral cavity as a single nodule.
  • Multiple granular cell tumors are rare, with the incidence reported to vary from 7-29% in adult cases of the tumor.
  • We describe a case of multiple cutaneous granular cell tumors in the right lumber and back regions along with a brief review of the published work on multiple cutaneous granular cell tumors.
  • [MeSH-major] Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 19712278.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 9007-34-5 / Collagen
  • [Number-of-references] 25
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9. Singhi AD, Montgomery EA: Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol; 2010 Aug;34(8):1186-92
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  • [Title] Colorectal granular cell tumor: a clinicopathologic study of 26 cases.
  • Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA).
  • Although GCTs were benign tumors in this series, if incompletely excised regrowth of the lesion may occur and therefore, follow-up may be warranted.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Colectomy. Colonoscopy. Female. Humans. Immunohistochemistry. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. S100 Proteins / analysis

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  • (PMID = 20661017.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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10. Jin B, Saleh H: Pitfalls in the diagnosis of adult rhabdomyoma by fine needle aspiration: report of a case and a brief literature review. Diagn Cytopathol; 2009 Jul;37(7):483-6
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  • Adult rhabdomyoma is a rare benign tumor of striate muscle tissue usually located in the head and neck region.
  • Cytomorphologically, the tumor cells have eosinophilic finely granular cytoplasm, which sometimes can mimic other tumors.
  • We report a case of adult rhabdomyoma, which was initially misinterpreted as granular cell tumor on FNA biopsy due to lacking of typical cytological features of adult rhabdomyoma.
  • We recommend that adult rhabdomyoma should be included in differential diagnoses when the cytological features are suggestive of granular cell tumor.
  • [MeSH-major] Muscle Proteins / metabolism. Neoplasm Proteins / metabolism. Rhabdomyoma / metabolism. Rhabdomyoma / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19217050.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Muscle Proteins; 0 / Neoplasm Proteins
  • [Number-of-references] 13
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11. Makishima H, Ito T, Asano N, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Suzuki T, Kobayashi H, Kiyosawa K, Ishida F: Significance of chemokine receptor expression in aggressive NK cell leukemia. Leukemia; 2005 Jul;19(7):1169-74
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  • [Title] Significance of chemokine receptor expression in aggressive NK cell leukemia.
  • Natural killer (NK) cell-type lymphoproliferative diseases of granular lymphocytes can be subdivided into aggressive NK cell leukemia (ANKL) and chronic NK cell lymphocytosis (CNKL).
  • The mechanisms of cell trafficking associated with the chemokine system have been investigated in NK cells.
  • These results indicated that the chemokine system might play an important role in the pathophysiology of ANKL and that chemokine receptor profiling might be a novel tool for discriminating ANKL cells from benign NK cells.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Biomarkers, Tumor / physiology. Cell Movement / drug effects. Cell Movement / physiology. Chemokines / pharmacology. Child. Female. Gene Expression Profiling. Humans. Male. Middle Aged. Phenotype. Receptors, CCR5 / genetics. Receptors, CCR5 / physiology. Receptors, Interleukin-8A / genetics. Receptors, Interleukin-8A / physiology


12. Garrido E, Marín E, González C, Juzgado D, Boixeda D, Vázquez-Sequeiros E: [Endoscopic mucosal resection of Abrikosoff's tumor of the esophagus]. Gastroenterol Hepatol; 2008 Nov;31(9):572-5
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  • [Title] [Endoscopic mucosal resection of Abrikosoff's tumor of the esophagus].
  • [Transliterated title] Mucosectomía endoscópica de un tumor de Abrikosoff esofágico.
  • Abrikosoff's tumor (AT), or granular cell tumor (GCT), is relatively rare in the gastrointestinal tract, where the most common site is the esophagus.
  • This tumor is usually found incidentally when an upper gastrointestinal endoscopy is carried out for another reason.
  • The origin of GCT is neurogenic and the tumor is composed of eosinophilic granular cytoplasm and PAS-positive cells, which show the S-100 protein on immunohistochemistry.
  • Although GCT is usually clinically and histologically benign, some malignant cases have been reported.
  • Consensus is lacking on the treatment and follow-up of this tumor.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagoscopy. Granular Cell Tumor / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 19091245.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / S100 Proteins
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13. Lu D, Vohra P, Chu PG, Woda B, Rock KL, Jiang Z: An oncofetal protein IMP3: a new molecular marker for the detection of esophageal adenocarcinoma and high-grade dysplasia. Am J Surg Pathol; 2009 Apr;33(4):521-5
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  • IMP3 is an oncofetal protein and has been demonstrated to be associated with aggressive tumor behavior.
  • IMP3 showed strong cytoplasmic granular staining in 138 of 147 (94%) of invasive esophageal adenocarcinomas, 13 of 14 (93%) of metastatic esophageal adenocarcinomas, and 49 of 52 (94%) of high-grade dysplasias.
  • Expression of IMP3 was not found in adjacent benign squamous and glandular mucosa.
  • [MeSH-major] Adenocarcinoma / diagnosis. Barrett Esophagus / diagnosis. Biomarkers, Tumor / metabolism. Esophageal Neoplasms / diagnosis. Neoplasm Proteins / metabolism. Precancerous Conditions / diagnosis. RNA-Binding Proteins / metabolism
  • [MeSH-minor] Cell Transformation, Neoplastic. Esophagus / metabolism. Esophagus / pathology. Esophagus / surgery. Fluorescent Antibody Technique, Direct. Humans. Immunoenzyme Techniques. Mucous Membrane / metabolism. Mucous Membrane / pathology

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  • (PMID = 19047899.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / IMP3 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Proteins
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14. Scaranelo AM, Bukhanov K, Crystal P, Mulligan AM, O'Malley FP: Granular cell tumour of the breast: MRI findings and review of the literature. Br J Radiol; 2007 Dec;80(960):970-4
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  • [Title] Granular cell tumour of the breast: MRI findings and review of the literature.
  • Granular cell tumours (GCTs) are uncommon, usually benign neoplasms that can mimic malignancy on breast imaging.
  • We report a case of granular cell tumour of the breast presenting as a suspicious lesion on breast imaging, and review the MRI features of GCTs.
  • [MeSH-major] Breast Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 17940129.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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15. Lee MH, Kim NR, Ryu JA: Cyst-like solid tumors of the musculoskeletal system: an analysis of ultrasound findings. Skeletal Radiol; 2010 Oct;39(10):981-6
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  • Twenty-three masses were identified, of which initial interpretation on gray scale included cystic tumor which pathology revealed to be solid tumors.
  • RESULTS: Of 23 masses, there were 5 giant cell tumors of the tendon sheath, 4 schwannomas, 3 vascular leiomyomas, 2 benign fibrous histiocytomas, 2 dermatofibrosarcoma protuberans, 2 granular cell tumors, 1 dermatofibroma, 1 fibroma of the tendon sheath, 1 fibromatosis, 1 eccrine spiradenoma, and 1 granulation tissue.

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  • [Cites] AJR Am J Roentgenol. 2008 Jun;190(6):1621-6 [18492916.001]
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  • (PMID = 20186412.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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16. Hascalik S, Celik O, Sarac K, Meydanli MM, Alkan A, Mizrak B: Metabolic changes in pelvic lesions: findings at proton MR spectroscopic imaging. Gynecol Obstet Invest; 2005;60(3):121-7
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  • RESULTS: Spectroscopy analysis of serous, mucinous and undifferentiated carcinoma of the ovary revealed Cho, lactate and lipid signals, but granulosa-theca cell tumor showed only a lipid signal.
  • The Cho signal was obtained from only 3 patients with mature cystic teratoma but none of the other benign ovarian tumors and pelvic abscesses.
  • A lipid signal was detected in 3 patients diagnosed with pelvic abscess and all benign ovarian tumors.
  • CONCLUSION: MRS demonstrates significant differences in metabolite concentration between benign and malignant ovarian tumors and pelvic abscesses.
  • [MeSH-minor] Abdominal Abscess / metabolism. Abdominal Abscess / pathology. Adult. Aged. Choline / metabolism. Creatine / metabolism. Dermoid Cyst / metabolism. Dermoid Cyst / pathology. Diagnosis, Differential. Endometriosis / metabolism. Endometriosis / pathology. Female. Granular Cell Tumor / metabolism. Granular Cell Tumor / pathology. Humans. Lipid Metabolism. Middle Aged. Neoplasms, Cystic, Mucinous, and Serous / metabolism. Neoplasms, Cystic, Mucinous, and Serous / pathology. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Protons. Teratoma / metabolism. Teratoma / pathology

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15920339.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Protons; MU72812GK0 / Creatine; N91BDP6H0X / Choline
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17. Ruschel HC, Beilke LP, Beilke RP, Kramer PF: Congential epulis of newborn: report of a spontaneous regression case. J Clin Pediatr Dent; 2008;33(2):167-9
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  • Congenital epulis of newborn is a rare benign tumor that is also known as a congenital granular cell tumor.

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  • (PMID = 19358386.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Mabongo M, Wood NH, Lemmer J, Feller L: Congenital epulis. A case report. SADJ; 2008 Jul;63(6):350-1
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  • Congenital epulis (CE) is an uncommon granular cell lesion of unknown pathogenesis and uncertain histogenesis that presents at birth.
  • It is a benign hamartoma that may interfere with feeding and respiration.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital

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  • (PMID = 18811099.001).
  • [ISSN] 1029-4864
  • [Journal-full-title] SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging
  • [ISO-abbreviation] SADJ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] South Africa
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19. Abraham T, Jackson B, Davis L, Yu J, Peterson C: Mohs surgical treatment of a granular cell tumor on the toe of a child. Pediatr Dermatol; 2007 May-Jun;24(3):235-7
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  • [Title] Mohs surgical treatment of a granular cell tumor on the toe of a child.
  • Granular cell tumors are uncommon, usually benign tumors of neural origin.
  • We report a granular cell tumor on the distal toe of a 5-year-old child, removed with Mohs surgery.
  • Review of the English language literature revealed four previously reported granular cell tumors treated with Mohs micrographic surgery, none of which was in a child.
  • [MeSH-major] Granular Cell Tumor / surgery. Mohs Surgery. Skin Neoplasms / surgery. Toes / surgery

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  • (PMID = 17542870.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Williams RW, Grave B, Stewart M, Heggie AA: Prenatal and postnatal management of congenital granular cell tumours: a case report. Br J Oral Maxillofac Surg; 2009 Jan;47(1):56-8
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  • [Title] Prenatal and postnatal management of congenital granular cell tumours: a case report.
  • Congenital granular cell tumour is a rare, benign, soft tissue lesion of the oral cavity.
  • Large or multiple lesions can cause mechanical obstruction of the oral cavity and may result in prenatal polyhydramnios, and postnatal feeding and respiratory problems.We present a case in which prenatal diagnostic imaging was used in the successful management of an infant with a large congenital granular cell tumour.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / congenital. Granular Cell Tumor / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 18556098.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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21. Sterker I, Hagert-Winkler A, Gradistanac T, Frerich B: [Granular cell tumor of the orbit]. Ophthalmologe; 2007 Sep;104(9):803-5
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  • [Title] [Granular cell tumor of the orbit].
  • Granular cell tumor (GCT, Abrikossoff tumor) is an extremely rare, benign tumor with a neurogenic origin occurring most commonly in the upper aerodigestive tract.
  • [MeSH-major] Granular Cell Tumor. Orbital Neoplasms

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  • (PMID = 17440732.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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22. Devi K, Mohanty P, Mohanty L, Bhuyan P, Mishra A, Hazra K: Cytodiagnosis of granular cell tumor: a case report. Indian J Pathol Microbiol; 2007 Jan;50(1):61-2
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  • [Title] Cytodiagnosis of granular cell tumor: a case report.
  • Fine needle aspiration diagnosis was benign granular cell tumor which was confirmed by histopathology.
  • Since it is an uncommon tumor, of controversial histogenesis, it is being reported here.
  • [MeSH-major] Granular Cell Tumor / diagnosis

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  • (PMID = 17474262.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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23. Abbas F, Memon A, Siddiqui T, Kayani N, Ahmad NA: Granular cell tumors of the urinary bladder. World J Surg Oncol; 2007;5:33
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  • [Title] Granular cell tumors of the urinary bladder.
  • BACKGROUND: Granular cell tumors (GCTs) are extremely rare lesions of the urinary bladder with only nine cases being reported in world literature of which one was malignant.
  • Generally believed to be of neural origin based on histochemical, immunohistochemical, and ultrastructural studies; they mostly follow a clinically benign course but are commonly mistaken for malignant tumors since they are solid looking, ulcerated tumors with ill-defined margins.
  • MATERIALS AND METHODS: We herein report two cases of GCTs, one benign and one malignant, presenting with gross hematuria in a 14- and a 47-year-old female, respectively.
  • The benign tumor was successfully managed conservatively with transurethral resection alone while for the malignant tumor, radical cystectomy, hysterectomy with bilateral salpingo-oophorectomy, anterior vaginectomy, plus lymph node dissection was done.
  • CONCLUSION: We recommend careful pathologic assessment for establishing the appropriate diagnosis and either a conservative or aggressive surgical treatment for benign or localized malignant GCT of the urinary bladder, respectively.
  • [MeSH-major] Cystoscopy / methods. Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Neoplasm Invasiveness / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biopsy, Needle. Emergency Service, Hospital. Female. Follow-Up Studies. Hematuria / diagnosis. Hematuria / etiology. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Nephrostomy, Percutaneous / methods. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17355632.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1828733
  • [General-notes] NLM/ Original DateCompleted: 20070810
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24. Dhingra S, Nada R, Rayat CS, Joshi K: Unusual eosinophilic variant of chromophobe cell renal carcinoma--an ultrastructural diagnosis. Indian J Pathol Microbiol; 2005 Apr;48(2):255-7
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  • [Title] Unusual eosinophilic variant of chromophobe cell renal carcinoma--an ultrastructural diagnosis.
  • A case of eosinophilic variant of chromophobe cell renal carcinoma (EVCCRC), an uncommon variety of renal cell carcinoma, occurred in a 72 year old male.
  • EVCCRC is a potentially malignant neoplasm whereas renal oncocytoma is totally benign.
  • Staining with Hale's Colloidal Iron using modified Mowry's technique showed granular cytoplasmic positivity.
  • The diagnosis was confirmed by ultrastructural examination of the tumor which revealed unique features of EVCCRC like presence of numerous cytoplasmic microvesicles along with mitochondria displaying tubulo-vesicular cristae.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / ultrastructure. Eosinophils / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / ultrastructure


25. Laskin WB, Fetsch JF, Davis CJ Jr, Sesterhenn IA: Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. Hum Pathol; 2005 Mar;36(3):291-8
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  • [Title] Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases.
  • The occurrence of granular cell tumor (GCT) in penile tissue is very rare, with only 9 examples reported to date in the English-language literature.
  • Duration of symptoms before surgery ranged from 5 days to 2 years with the presence of an asymptomatic nodule representing the most common tumor-related complaint (n=8).
  • Microscopically, the tumors were moderate to highly cellular and were composed of oval to polygonal-shaped cells with abundant coarsely granular eosinophilic cytoplasm.
  • Tumor cells grew in infiltrating nests, cords, and trabeculae and showed neural (n=2) and vessel wall (n=1) invasion or formed a relatively well-marginated solid nodule.
  • A tumor demonstrated diffuse nuclear atypia and was classified as "atypical."
  • All tumors tested showed moderate to strong immunohistochemical expression of S100 protein (n=6) and low-affinity nerve growth factor receptor (n=5), which was useful for detecting small deposits of tumor and helpful in evaluating surgical margins.
  • Focal tumor cell immunoreactivity was observed for calretinin (4/6 cases) and glial fibrillary acidic protein (1/6 cases).
  • All patients underwent simple (local) excision of their tumor.
  • No patient experienced recurrence or metastatic spread of tumor although surgical margins were microscopically involved by tumor in 5 cases.
  • Benign GCT involving superficial soft tissue of the penis can be adequately managed by a simple excision.
  • [MeSH-major] Granular Cell Tumor / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Calbindin 2. Cell Nucleus / pathology. Cytoplasm / pathology. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Male. Middle Aged. Receptor, Nerve Growth Factor / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Treatment Outcome

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  • (PMID = 15791574.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Glial Fibrillary Acidic Protein; 0 / Receptor, Nerve Growth Factor; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins
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26. Scala WA, Fernandes AM, Duprat Ade C, Costa HO: Granular cell tumor of the larynx in children: a case report. Braz J Otorhinolaryngol; 2008 Sep-Oct;74(5):780-5
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  • [Title] Granular cell tumor of the larynx in children: a case report.
  • The granular cell tumor (GCT) is an uncommon neoplasm, with slow progression, usually benign, that can be found in any organ.
  • Among the major theories of origin and based on the strongest evidence, the most accepted one is that the tumor stems from neuronal tissue.
  • [MeSH-major] Granular Cell Tumor / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 19082363.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 13
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27. Rinaggio J, Cleveland D, Koshy R, Gallante A, Mirani N: Peripheral granular cell odontogenic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):676-9
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  • [Title] Peripheral granular cell odontogenic fibroma.
  • Peripheral odontogenic fibroma is a rare lesion that arises on the gingiva and can clinically mimic a variety of reactive lesions, benign neoplasms, and metastases.
  • An excisional biopsy showed the lesional stroma to contain numerous polyhedral granular cells with occasional interspersed islands of inactive odontogenic epithelium.
  • We believe this to represent the fourth case of peripheral granular cell odontogenic fibroma to be reported in detail in the literature.
  • [MeSH-major] Fibroma / pathology. Gingival Neoplasms / pathology. Granular Cell Tumor / pathology. Mandibular Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17223586.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Number-of-references] 8
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28. Walsh SN, Sangüeza OP: PEComas: a review with emphasis on cutaneous lesions. Semin Diagn Pathol; 2009 Aug;26(3):123-30
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  • The connection between angiomyolipoma (AML) of the kidney, clear cell sugar tumor (CCST) of the lung, and pulmonary lymphangioleiomyoma (LAM), was progressively discovered because of the histologic and immunophenotypic similarities between the three tumors and their frequent association with tuberous sclerosis complex (TSC).
  • Morphologically, analogous lesions found in other locations are composed of the unifying cell, the perivascular epithelioid cell (PEC).
  • These neoplasms are composed of nests and fascicles of clear to granular epithelioid and/or spindled cells with a consistent arrangement around blood vessels.
  • Most reported cutaneous PEComas follow a benign course, however, a malignant case has been reported.
  • [MeSH-major] Desmin / metabolism. Epithelioid Cells / pathology. Perivascular Epithelioid Cell Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Female. Humans. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • [CommentIn] Am J Dermatopathol. 2016 Feb;38(2):165-6 [26825164.001]
  • (PMID = 20043511.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
  • [Number-of-references] 65
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29. Papalas JA, Shaco-Levy R, Robboy SJ, Selim MA: Isolated and synchronous vulvar granular cell tumors: a clinicopathologic study of 17 cases in 13 patients. Int J Gynecol Pathol; 2010 Mar;29(2):173-80
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  • [Title] Isolated and synchronous vulvar granular cell tumors: a clinicopathologic study of 17 cases in 13 patients.
  • Granular cell tumors (GCTs) are benign Schwann cell-derived neoplasms occurring throughout the body.
  • Cytologically, the tumors displayed round to polygonal cells with a granular cytoplasm, small hyperchromatic nuclei with minimal pleomorphism, and less than 2 mitoses per 10 high power fields.
  • One tumor (1/17) consisted of cells with predominantly vesicular nuclei and prominent nucleoli and was classified as an atypical vulvar GCT.
  • Eight of 17 tumor excision specimens had positive margins.
  • Patients with multifocal tumors did not have a higher risk of recurrence per tumor, compared with patients with isolated disease, regardless of the margin status.
  • As granular cell neoplasms have such a low risk or recurrence and behave generally in an indolent manner, aggressive therapy is usually unwarranted.
  • [MeSH-major] Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 20173503.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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30. Kent M, d'Amato T, Nordman C, Schuchert M, Landreneau R, Alvelo-Rivera M, Luketich J: Minimally invasive resection of benign esophageal tumors. J Thorac Cardiovasc Surg; 2007 Jul;134(1):176-81
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  • [Title] Minimally invasive resection of benign esophageal tumors.
  • OBJECTIVE: Benign tumors of the esophagus are uncommon.
  • METHODS: A retrospective review of patients who underwent resection of benign esophageal tumors between 1990 and 2005 was conducted.
  • Operative approach, tumor size, and outcomes after surgery were recorded.
  • RESULTS: Twenty patients were identified (leiomyoma: n = 15; stromal tumor: n = 3; granular cell tumor, n = 1; schwannoma: n = 1).
  • Mean tumor size in the open group was 8.1 cm (range 7-10 cm) compared with 3.5 cm (range 0.9-8 cm) in the minimally invasive group.
  • Five patients subsequently required fundoplication for worsening (n = 3) or new-onset (n = 2) gastroesophageal reflux disease after tumor resection.
  • CONCLUSIONS: Minimally invasive resection of benign esophageal tumors is technically safe and associated with a shorter length of stay compared with open approaches.
  • [MeSH-major] Esophageal Neoplasms / surgery. Granular Cell Tumor / surgery. Laparoscopy / methods. Leiomyoma / surgery. Neurilemmoma / surgery. Thoracoscopy / methods

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  • (PMID = 17599505.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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31. Chung EM, Cube R, Hall GJ, González C, Stocker JT, Glassman LM: From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation. Radiographics; 2009 May-Jun;29(3):907-31
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  • The spectrum of breast lesions in children and adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign.
  • After onset of puberty, most cases of breast enlargement arise from benign fibroadenoma in girls and gynecomastia in boys.
  • These conditions have specific imaging appearances, although juvenile (often giant) fibroadenoma cannot be distinguished from phyllodes tumor, which can be benign or malignant.
  • A diagnosis of juvenile papillomatosis (a benign lesion) portends later development of breast cancer, and patients with this condition should be closely monitored.
  • The most common primary breast malignancy is malignant phyllodes tumor.
  • Primary breast carcinoma is exceedingly rare in the pediatric age group, but its imaging appearance in children is the same as seen in adults and is different from that of almost all benign lesions.
  • [MeSH-minor] Adolescent. Breast / abnormalities. Breast / anatomy & histology. Breast / growth & development. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms, Male / diagnosis. Breast Neoplasms, Male / pathology. Breast Neoplasms, Male / radiography. Breast Neoplasms, Male / secondary. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / radiography. Carcinoma, Ductal, Breast / ultrasonography. Child. Child, Preschool. Female. Fibroadenoma / diagnosis. Fibroadenoma / pathology. Fibroadenoma / radiography. Granular Cell Tumor / diagnosis. Granular Cell Tumor / pathology. Granular Cell Tumor / radiography. Gynecomastia / pathology. Gynecomastia / radiography. Humans. Infant. Infant, Newborn. Male. Nipples / abnormalities. Papilloma / diagnosis. Papilloma / pathology. Papilloma / radiography. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology. Phyllodes Tumor / radiography. Puberty. Puberty, Precocious / diagnosis. Young Adult

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  • (PMID = 19448124.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 90
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32. Beer TW, Drury P, Heenan PJ: Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases. Am J Dermatopathol; 2010 Aug;32(6):533-40
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  • Histological variants identified included keloidal (n = 8), clear cell (n = 3), and granular cell (n = 3), plaque like (n = 4), and myxoid (n = 1).
  • Bland cytological appearances (spindle cell nonpleomorphic AFX) were noted in 5 tumors, with osteoclast-like giant cells in 2.
  • Histological mimics, such as poorly differentiated squamous cell carcinoma, must be carefully excluded.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged


33. Dupuis C, Coard KC: A review of granular cell tumours at the University Hospital of the West Indies: 1965-2006. West Indian Med J; 2009 Mar;58(2):138-41
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  • [Title] A review of granular cell tumours at the University Hospital of the West Indies: 1965-2006.
  • OBJECTIVE: Granular cell tumours are uncommon lesions that occur in a wide variety of sites.
  • They are usually benign, but as they are infrequently diagnosed preoperatively, they may be confused clinically with malignant lesions.
  • The objective of this study was to assess the relative frequency and the clinicopathologic characteristics of granular cell tumours identified at the University Hospital of the West Indies (UHWI) over a 41-year period.
  • METHODS: The archives of surgical pathology reports in the Department of Pathology at the UHWI from 1965 to 2006 were searched for all cases of granular cell tumour.
  • RESULTS: One hundred and thirty cases of granular cell tumours were found in 122 patients.
  • CONCLUSIONS: Compared with other studies, there was a notable difference in the distribution of granular cell tumours in this series.
  • [MeSH-major] Granular Cell Tumor / epidemiology. Granular Cell Tumor / pathology

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  • (PMID = 21866599.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Jamaica
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34. Zarovnaya E, Black C: Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med; 2005 Aug;129(8):1032-6
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  • [Title] Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
  • CONTEXT: The differentiation of pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma is a difficult and frequently encountered distinction, especially in biopsy specimens from head and neck mucosa.
  • OBJECTIVE: To distinguish pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma, utilizing a panel of antibodies to various epithelial and stromal elements (p53, matrix metalloproteinase 1, E-cadherin, and collagen IV) that has been shown to be useful in differentiating intestinal adenomas with invasive adenocarcinoma from displaced adenomatous epithelium.
  • DESIGN: Thirty-three archival specimens (16 squamous cell carcinoma [12 with invasion and 4 with microinvasion] and 17 pseudoepitheliomatous hyperplasia) from head and neck mucosal locations were immunostained and examined by the authors.
  • RESULTS: We found increased nuclear staining of the invasive tumor cells with p53.
  • There was decreased staining within invasive tumor nests with E-cadherin.
  • There was highly significant increased staining within tumor cells and adjacent stroma with matrix metalloproteinase 1 (P < .001).
  • It appeared fragmented in benign inflamed and malignant areas and therefore was not useful.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Granular Cell Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Mouth Mucosa / pathology. Skin Diseases / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Cadherins / metabolism. Child. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Immunoenzyme Techniques. Male. Matrix Metalloproteinase 1 / metabolism. Middle Aged. Tumor Suppressor Protein p53 / metabolism


35. Laco J: [Congenital granular cell epulis: a case report]. Cesk Patol; 2009 Oct;45(4):117-9
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  • [Title] [Congenital granular cell epulis: a case report].
  • Congenital granular cell epulis is a rare benign lesion occuring exclusively in newborns as a solitary or multiple swelling of alveolar mucosa of either maxilla or mandible.
  • On 24th postnatal day, the lesions were under general anesthesia excised and sent for microscopic examination, which revealed congenital granular cell epulis.
  • Immunohistochemically, granular cells showed expression of both vimentin and PGP 9.5, whereas the proof of S100 protein and inhibin was negative.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital

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  • (PMID = 20301840.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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36. Abo-Hager EA, Khater DS, Ahmed MM: Exploration of the histogenesis of congenital granular cell epulis: an immunohistochemical study. J Egypt Natl Canc Inst; 2009 Jun;21(2):77-83
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  • [Title] Exploration of the histogenesis of congenital granular cell epulis: an immunohistochemical study.
  • OBJECTIVE: Congenital granular cell epulis is a benign soft tissue lesion of the neonate that arises from the alveolar ridges of the jaws in newborns.
  • The aim of this study is to define the histogenesis of congenital granular cell epulis by using several immunohistochemical markers.
  • MATERIALS AND METHODS: A series of six cases of congenital granular cell epulis were immunostained with a panel of antibodies (NSE, CD68, CD99, Mesothelin, Inhibin-a, GFAP, Dystrophin, NGFR/p75 and TLR1).
  • RESULTS: Granular cells of all cases showed positive cytoplasmic immunostaining for NSE and CD68.
  • Granular and interstitial cells in all cases were negative with the remaining antibodies.
  • The immunoreactivity of the granular cells to NSE showed the statistically significantly highest mean area percent.
  • CONCLUSION: The expression of NSE and CD99 in all cases of the present study support a neuroectodermal derivation of congenital granular cell epulis.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gingival Neoplasms / metabolism. Gingival Neoplasms / pathology. Granular Cell Tumor / metabolism. Granular Cell Tumor / pathology

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  • (PMID = 21057558.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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37. Wiel J, Luis W, Kempf HG: [The interesting case -- case no. 70]. Laryngorhinootologie; 2005 Mar;84(3):196-9
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  • We will report two cases of newborn girls, who could not be breast fed because of a benign tumour in their oral cavity.
  • The size of neoplasm was in one case 3 x 2 cm, in the other one 2 x 1.5 cm.
  • Histological findings showed large tumour cells with abundant granular eosinophilic cytoplasm and a prominent vascularity.
  • All these findings are characteristic of congenital granular cell tumour and its synonym congenital epulis.
  • It differs from adult granular cell tumours by its prominent vascularity, the presence of scattered remnants of odontogenic epithelium, and the strong phosphatase activity.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Mouth Neoplasms / congenital

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  • (PMID = 15770569.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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38. Aneiros-Fernandez J, Arias-Santiago S, Husein-Elahmed H, Ovalle F, Siendones MI, Aneiros-Cachaza J: Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall. J Clin Med Res; 2010 Aug 18;2(4):185-8
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  • [Title] Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall.
  • We report the clinical-morphological study of a granular cell tumor in dermal/hypodermal junction and subcutaneous fat left breast of an 83-year-old woman with a family history of breast carcinoma.
  • The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors.
  • We present a benign lesion that clinically reproduces a breast carcinoma.
  • KEYWORDS: Granular cell tumor; Breast; Differential diagnosis; Cutaneous.

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  • (PMID = 21629537.001).
  • [ISSN] 1918-3011
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3104657
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39. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
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  • [Title] Recurrent granular cell tumor: how to treat.
  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The mass was excised two times at different centers and diagnosed as granular cell tumor after the pathologic examination.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Józefowicz-Korczyńska M, Kozłowski Z, Pietruszewska W, Lukomski M: [Granular-cell myoblastoma of the larynx clinical analysis]. Otolaryngol Pol; 2005;59(6):807-12
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  • [Title] [Granular-cell myoblastoma of the larynx clinical analysis].
  • Clinical date of four cases of granular-cell myoblastoma tumors arising in the larynx and clinical analysis of 11 cases published in Polish literature were reviewed and studied.
  • Granular-cell tumor is a rare, usually benign neoplasm that can occur in various part of the body.
  • The larynx tumor is accounting for 7% to 10% of all reported cases.
  • The tumor was generally presented in patients in their forth and fifth decade.
  • Clinically the tumors were considered benign.
  • In one case because the location and size of the tumor subtotal laryngectomy was necessary to conduct.
  • [MeSH-major] Granular Cell Tumor / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16521442.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 18
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41. Angiero F, Crippa R, Stefani M: Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery. Minerva Stomatol; 2006 Jul-Aug;55(7-8):423-30
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  • [Title] Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery.
  • METHODS: Between 1999 and 2004, 11 patients (6 females, 5 males; age range 28-66 years) were treated for tumours classified as being of neural origin; they were all myoblastomas or granular cells tumours (ex Abrikossoff tumour).
  • CONCLUSIONS: Granular cell tumour is a benign neoplasm with a tendency to relapse if not completely removed.
  • [MeSH-major] Granular Cell Tumor / surgery. Laser Therapy. Mouth Neoplasms / surgery

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  • (PMID = 17041542.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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42. Iglesias A, Arias M, Santiago P, Rodríguez M, Mañas J, Saborido C: Benign breast lesions that simulate malignancy: magnetic resonance imaging with radiologic-pathologic correlation. Curr Probl Diagn Radiol; 2007 Mar-Apr;36(2):66-82
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  • [Title] Benign breast lesions that simulate malignancy: magnetic resonance imaging with radiologic-pathologic correlation.
  • The typical appearance of benign breast conditions on magnetic resonance imaging (MRI) is well established and diagnosis is usually easy.
  • However, cases of benign breast lesions that are extremely difficult to differentiate from malignant breast tumors are occasionally encountered in MRI of the breast because overlap between benign and malignant lesions characteristics is found.
  • This article describes the MRI features of a variety of suspicious breast conditions that were confirmed to be benign in the histopathologic study.
  • We evaluated both enhancement kinetics and lesion morphological information to differentiate malignant from benign lesions.
  • Lesions evaluated included benign proliferative breast disease, fibroadenoma, intraductal papilloma, granular cell tumor, pseudoangiomatous stromal hyperplasia, fat necrosis, mastitis, inflammatory granuloma, epidermal inclusion cyst, and benign intramammary lymph node.
  • [MeSH-minor] Breast Cyst / diagnosis. Breast Neoplasms / diagnosis. Diagnosis, Differential. Female. Fibroadenoma / diagnosis. Granular Cell Tumor / diagnosis. Humans. Mastitis / diagnosis. Papilloma / diagnosis

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  • (PMID = 17331838.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Kucher C, McNiff JM: Epithelioid fibrous papule - a new variant. J Cutan Pathol; 2007 Jul;34(7):571-5
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  • Fibrous papules (FPs) are common benign lesions occurring most frequently on the nose.
  • Multiple variants have been described, including classic, hypercellular, clear cell, pigmented, pleomorphic, inflammatory and granular FPs.
  • Immunoperoxidase stains show that the cells of this 'epithelioid fibrous papule' are reactive for procollagen, and are negative for NKI/C3, unlike previously described clear cell variants.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Procollagen / metabolism

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  • (PMID = 17576337.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Procollagen
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44. López-Jornet P: Granular cell tumor of the tongue. N Y State Dent J; 2008 Aug-Sep;74(5):71-2
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  • [Title] Granular cell tumor of the tongue.
  • Granular cell tumor is an uncommon benign hamartomatous lesion occurring in almost any part of the body.
  • Granular cell lesions may be found in other diverse sites, such as the jaw, skin, gastrointestinal tract and respiratory tract.
  • In this paper, we report the occurrence of an oral granular cell tumor affecting the tongue of a 45-year-old male patient.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 18982973.001).
  • [ISSN] 0028-7571
  • [Journal-full-title] The New York state dental journal
  • [ISO-abbreviation] N Y State Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Mindea SA, Kaplan KJ, Howard MA, O'Leary ST: Granular cell tumor involving the axillary nerve: an unusual occurrence. Case report. Neurosurg Focus; 2007;22(6):E24
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  • [Title] Granular cell tumor involving the axillary nerve: an unusual occurrence. Case report.
  • Granular cell tumors (GCTs) are benign lesions that, paradoxically, despite originating from the Schwann cell, are most commonly seen in nonneuronal tissue including the skin, subcutaneous tissue, and tongue.
  • [MeSH-major] Axilla / innervation. Granular Cell Tumor / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / radiography

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  • (PMID = 17613216.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Porter GJ, Evans AJ, Lee AH, Hamilton LJ, James JJ: Unusual benign breast lesions. Clin Radiol; 2006 Jul;61(7):562-9
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  • [Title] Unusual benign breast lesions.
  • The purpose of this article is to show examples of the radiological (mammography and/or ultrasound) and pathological appearances of unusual benign breast lesions.
  • The conditions covered are granular cell tumours, fibromatosis, nodular fasciitis, myofibroblastomas, haemangiomas, neurofibromas, and leiomyomas.
  • [MeSH-minor] Fasciitis / radiography. Fasciitis / ultrasonography. Female. Fibroma / radiography. Fibroma / ultrasonography. Granular Cell Tumor / radiography. Granular Cell Tumor / ultrasonography. Hemangioma / radiography. Hemangioma / ultrasonography. Humans. Leiomyoma / radiography. Leiomyoma / ultrasonography. Mammography / methods. Neoplasms, Muscle Tissue / radiography. Neoplasms, Muscle Tissue / ultrasonography. Neurofibroma / radiography. Neurofibroma / ultrasonography. Ultrasonography, Mammary / methods

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  • (PMID = 16784941.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 26
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47. Sidwell RU, Rouse P, Owen RA, Green JS: Granular cell tumor of the scrotum in a child with Noonan syndrome. Pediatr Dermatol; 2008 May-Jun;25(3):341-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the scrotum in a child with Noonan syndrome.
  • Granular cell tumor is a rare neoplasm thought to be of neural origin, composed of cells with distinctive granular cytoplasm.
  • Granular cell tumors most often arise on the tongue, but can occur at any body site, and therefore initial presentation to dermatologists is common.
  • We report a granular cell tumor of the scrotum in a child with Noonan syndrome, known to have a mutation in the PTPN11 gene.
  • No previous reports of granular cell tumor of the scrotum in a child are found.
  • The tumor is usually benign; however, it can have a high local recurrence rate (variable between 2% and 50% dependent on whether initial excision is complete and on the occurrence of an infiltrative growth pattern) and therefore long-term follow-up is necessary.
  • This case highlights the occurrence of granular cell tumor, a diagnosis not to be missed by the dermatologist.
  • In addition, we postulate the possible role of PTPN11 mutations in the development of granular cell tumor.
  • [MeSH-major] Genital Neoplasms, Male / genetics. Granular Cell Tumor / genetics. Mutation. Noonan Syndrome / complications. Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics

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  • (PMID = 18577039.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11
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48. Rodriguez y Baena R, Di Ieva A, Colombo P, Collini P, Navarria P, Scorsetti M, Gaetani P, Santoro A: Intramedullary astrocytoma with granular cell differentiation. Neurosurg Rev; 2007 Oct;30(4):339-43; discussion 343
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  • [Title] Intramedullary astrocytoma with granular cell differentiation.
  • Granular cell astrocytomas are uncommon tumors of the central nervous system (CNS) of which no cases have been documented in the spinal cord.
  • This variant of glioma should not be confused with benign granular cell tumor which, although rare, has been well characterized in the spinal cord.
  • At surgery, the tumor was found to be infiltrating a posterior column with no dural attachment.
  • The histological diagnosis was astrocytoma with granular cell differentiation.
  • In addition to documenting a unique example of intramedullary granular cell astrocytoma, we review the literature to investigate differences from other tumors with granular changes described in the spinal cord.

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  • [Cites] Br J Neurosurg. 1997 Jun;11(3):257-9 [9231019.001]
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  • (PMID = 17483971.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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49. Rodriguez FJ, Scheithauer BW, Roncaroli F, Silva AI, Kovacs K, Brat DJ, Jin L: Galectin-3 expression is ubiquitous in tumors of the sellar region, nervous system, and mimics: an immunohistochemical and RT-PCR study. Am J Surg Pathol; 2008 Sep;32(9):1344-52
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  • Galectin-3 expression has been reported in spindle cell oncocytoma, certain pituitary adenoma subtypes, astrocytomas, oligodendrogliomas, and meningiomas.
  • Significant differences in protein expression were noted in the following 2 settings: specific meningioma subtypes (P=0.004, Fisher exact test) wherein clear cell meningioma demonstrated weak protein expression when compared with other meningioma variants.
  • Galectin-3 was also strongly expressed in benign nerve sheath tumors but only moderately expressed in malignant peripheral nerve sheath tumors (P=0.0009, Fisher exact test).
  • Although galectin-3 positivity is a key feature of the immunophenotype of spindle cell oncocytoma, its consistent expression in other morphologically similar tumors (meningioma, pituicytoma, nerve sheath tumors, granular cell tumor, metastases) makes it of little use in the differential diagnosis of sellar region tumors, a setting in which it should be discouraged.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18670355.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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50. Andrade ES, Filho JR, Rocha NS, Neto IC, Camargo IB: Isolated intra-oral granular cell tumor: report of two cases and review of the literature. Acta Odontol Latinoam; 2010;23(2):99-104
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  • [Title] Isolated intra-oral granular cell tumor: report of two cases and review of the literature.
  • Granular cell tumor (GCT) is a relatively uncommon lesion occurring in almost any part of the body, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most GCTs are benign.
  • The tumor generally occurs in middle-aged or older adults.
  • As most granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • Differential diagnoses include fibrous hyperplasia, minor salivary gland tumor condyloma acuminatum and neurilemmoma.
  • The main clinical pathology and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21053681.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Argentina
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51. Hoseini AT, Razavi SM, Khabazian A: Lipoma in oral mucosa: two case reports. Dent Res J (Isfahan); 2010;7(1):41-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoma is a common tumor of soft tissue.
  • Its location on the oral mucosa is rare, representing 1% to 5% of benign oral tumors although it is the most mesenchymal tumor of the trunk and proximal por-tions of extremities.
  • The overlying epithelium is intact, and superficial blood vessels are usually evident over the tumor.
  • Other benign connective tissue lesions such as granular cell tumor, neurofibroma, traumatic fibroma and salivary gland lesions (mucocele and mixed tumor) might be included in differential diagnosis.

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  • (PMID = 21448446.001).
  • [ISSN] 2008-0255
  • [Journal-full-title] Dental research journal
  • [ISO-abbreviation] Dent Res J (Isfahan)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3065337
  • [Keywords] NOTNLM ; Differential diagnosis / Lipoma / Pathology
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52. Huang BY, Castillo M: Nonadenomatous tumors of the pituitary and sella turcica. Top Magn Reson Imaging; 2005 Jul;16(4):289-99
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • While pituitary adenomas make up over 90% of all sellar masses, there are a number of less known tumors, both malignant and benign, which may arise within the sella turcica.
  • These include relatively common tumors such as meningiomas and craniopharyngiomas, as well as extremely rare tumors such as pituitary astrocytomas and granular cell tumors.
  • [MeSH-major] Craniopharyngioma / diagnosis. Ganglioneuroma / diagnosis. Granular Cell Tumor / diagnosis. Lymphoma / diagnosis. Meningioma / diagnosis. Pituitary Neoplasms / diagnosis. Sella Turcica / pathology

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  • (PMID = 16785844.001).
  • [ISSN] 0899-3459
  • [Journal-full-title] Topics in magnetic resonance imaging : TMRI
  • [ISO-abbreviation] Top Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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53. Joung MK, Lee YJ, Chung CU, Lee JE, Jung SS, Kim SY, Kim JO: A case of granular cell tumor of the trachea. Korean J Intern Med; 2007 Jun;22(2):101-5
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  • [Title] A case of granular cell tumor of the trachea.
  • The pathologic findings showed a benign granular cell tumor.
  • The respiratory symptoms resolved after biopsying the tumor.
  • On follow up, there were no signs of recurrence of the granular cell tumor after a period of 24 months.
  • [MeSH-major] Chest Pain / diagnosis. Granular Cell Tumor / diagnosis. Hemoptysis. Tracheal Neoplasms / diagnosis

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  • (PMID = 17616025.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2687619
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54. Godoy G, Mufarrij PW, Tsou HC, Torre P, Taneja SS: Granular cell tumor of scrotum: a rare tumor of the male external genitalia. Urology; 2008 Sep;72(3):716.e7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of scrotum: a rare tumor of the male external genitalia.
  • We report a rare case of granular cell tumor in the scrotum.
  • Granular cell tumors are soft-tissue neoplasms originating from Schwann cells that rarely affect male external genitalia.
  • They are essentially benign; therefore, the treatment is complete excision of the lesion.
  • Because the clinical presentation is not specific, the diagnosis of malignant granular cell tumors can be made only by the pathologist.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Genital Neoplasms, Male / pathology. Granular Cell Tumor / diagnosis. Granular Cell Tumor / pathology. Scrotum / pathology

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  • (PMID = 18384852.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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55. Saleh H, El-Fakharany M, Frankle M: Multiple synchronous granular cell tumors involving the colon, appendix and mesentery: a case report and review of the literature. J Gastrointestin Liver Dis; 2009 Dec;18(4):475-8
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  • [Title] Multiple synchronous granular cell tumors involving the colon, appendix and mesentery: a case report and review of the literature.
  • A granular cell tumor (GCT) is typically a benign neural tumor of Schwann cell origin that occurs in the 4th to 6th decade of life usually as a solitary painless nodule in the dermis or subcutis.
  • However, surgical resection of all the masses in an exploratory laporatomy proved them to be benign GCTs.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Colonic Neoplasms / diagnosis. Granular Cell Tumor / diagnosis. Incidental Findings. Mesentery / pathology. Neoplasms, Multiple Primary

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  • (PMID = 20076822.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 22
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56. Mentzel T, Schärer L, Kazakov DV, Michal M: Myxoid dermatofibrosarcoma protuberans: clinicopathologic, immunohistochemical, and molecular analysis of eight cases. Am J Dermatopathol; 2007 Oct;29(5):443-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dermatofibrosarcoma protuberans (DFSP) represents a locally aggressive mesenchymal neoplasm of skin and subcutis with characteristic clinicopathologic, immunohistochemical, and molecular findings.
  • In addition to typical cases, morphologic variants such as pigmented, fibrosarcomatous, myofibroblastic, and granular cell DFSP have been described.
  • Tumor size ranged from 1.5 to 12 cm.
  • Histologically, a nodular growth with peripheral diffuse infiltration, as well as a diffusely infiltrating growth of relatively uniform spindled and stellated tumor cells containing slightly enlarged nuclei, was noted.
  • Three cases were entirely myxoid, and in five cases more than 80% of the tumor area showed myxoid stromal changes.
  • In two cases each, focal fibrosarcomatous and focal giant cell fibroblastoma-like changes were present.
  • Scattered enlarged tumor cells were seen in two cases.
  • Immunohistochemically, tumor cells in all cases stained positively for CD34, and in one case each a focal expression of alpha-smooth muscle actin and epithelial membrane antigen (EMA) was noted.
  • In conclusion, myxoid DFSP represents a very rare morphologic variant with characteristic changes that has to be distinguished from benign and malignant myxoid mesenchymal neoplasms as superficial angiomyxoma, superficial acral fibromyxoma, myxoid solitary fibrous tumor, myxoid perineurioma, low-grade myxofibrosarcoma, low-grade fibromyxoid sarcoma, myxoid liposarcoma, and myxoid synovial sarcoma.
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Antigens, CD34 / metabolism. Cell Proliferation. Collagen Type I / genetics. Collagen Type I / metabolism. Diagnosis, Differential. Female. Gene Fusion / genetics. Humans. Male. Middle Aged. Mucin-1 / metabolism. Proto-Oncogene Proteins c-sis / genetics. Proto-Oncogene Proteins c-sis / metabolism. Translocation, Genetic

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  • (PMID = 17890911.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Collagen Type I; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-sis; 0 / collagen type I, alpha 1 chain
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57. Cserni G, Bori R, Sejben I: Vascular invasion demonstrated by elastic stain-a common phenomenon in benign granular cell tumors. Virchows Arch; 2009 Feb;454(2):211-5
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  • [Title] Vascular invasion demonstrated by elastic stain-a common phenomenon in benign granular cell tumors.
  • Granular cell tumor is generally benign, but rare malignant cases have been documented.
  • Venous invasion was incidentally identified with the orcein elastic stain in an otherwise benign granular cell tumor (propositus case).
  • Four further benign granular cell tumors were also analyzed; venous invasion was discovered in three.
  • It is suggested that vascular invasion is not uncommon in granular cell tumors and should not lead to the classification of the tumor as malignant or atypical.
  • [MeSH-major] Blood Vessels / pathology. Elastic Tissue / pathology. Granular Cell Tumor / pathology. Staining and Labeling / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Neoplasm Invasiveness

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  • [Cites] Dis Colon Rectum. 2007 Nov;50(11):1867-72 [17665249.001]
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  • (PMID = 19066954.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Punnya AV, Rekha K: "Ameloblastoma with mucous cells": review of literature and presentation of 2 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Dec;106(6):e20-6
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  • Ameloblastoma, a relatively rare benign odontogenic tumor; originates from the odontogenic epithelium and has been studied extensively for its unique clinicopathologic features.
  • It usually exhibits a range of histopathologic features, such as follicular, plexiform, acanthomatous, granular, basal cell, and desmoplastic variants, which are well recognized.
  • Histologically, the mucous cells in most cases were associated with areas of squamous metaplasia, suggesting a close relation between these 2 cell types.
  • [MeSH-minor] Adolescent. Adult. Cell Differentiation. Epithelial Cells / pathology. Humans. Male. Mucins / analysis

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  • (PMID = 19000605.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 28
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59. Barbuţa OI, Aprodu GS, Gavrilescu S, Mihaila D, Iliev G, Olaru V, Munteanu V, Savu A: [Congenital oropharyngeal tumors in the newborn: problems in team diagnosis and treatment]. Rev Med Chir Soc Med Nat Iasi; 2006 Oct-Dec;110(4):883-6
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  • Congenital epulis of the newborn is a rare tumour which is usually benign.
  • Epulis is also known as a congenital gingival granular cell tumour because of its histological features.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / diagnosis. Granular Cell Tumor / surgery

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  • (PMID = 17438893.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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60. Brunner EC, Romeike BF, Jung M, Comtesse N, Meese E: Altered expression of beta-catenin/E-cadherin in meningiomas. Histopathology; 2006 Aug;49(2):178-87
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  • AIMS: Meningiomas are generally slow-growing benign tumours representing approximately 20% of all primary intracranial tumours.
  • The NF2 encoded protein merlin appears to function as a tumour suppressor gene by controlling cadherin-mediated cell-cell adhesion.
  • The E-cadherin cell adhesion system includes beta-catenin that indirectly connects cadherin to actin filaments.
  • METHODS AND RESULTS: Immunohistochemical analysis revealed lack of E-cadherin expression at the cell membrane in 34% of meningiomas independent of their WHO grade.
  • An intense perinuclear granular immunoreactivity of beta-catenin without nuclear location was detected in the majority of meningiomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Aberrations. Chromosomes, Human, Pair 22 / genetics. Cytogenetic Analysis. Female. Gene Deletion. HeLa Cells. Humans. Immunohistochemistry. Karyotyping. Male. Microscopy, Fluorescence. Middle Aged. Neurofibromin 2 / genetics. Tumor Cells, Cultured

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  • (PMID = 16879395.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Neurofibromin 2; 0 / beta Catenin
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61. Padilla-Rodriguez AL, Padilla-Villalta A, Arandia Y: Synchronous benign and malignant mesenchymal breast tumor. Breast J; 2007 May-Jun;13(3):314-5
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  • [Title] Synchronous benign and malignant mesenchymal breast tumor.
  • [MeSH-minor] Breast Diseases / pathology. Female. Fibroma / pathology. Granular Cell Tumor / pathology. Humans. Middle Aged

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  • (PMID = 17461913.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Sokolova IA, Hes O, Michal M, Matsko DE: [Small-cell variant of renal oncocytoma]. Arkh Patol; 2007 Sep-Oct;69(5):34-6
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  • [Title] [Small-cell variant of renal oncocytoma].
  • Renal oncocytoma is a distinct benign tumor accounting for approximately 3-5% of all renal tumors.
  • This neoplasm is easily recognizable in its classic form: there are polygonal cells with abundant granular eosinophilic cytoplasm filled with mitochondria.
  • The tumor cells are arranged in nests and tubular pattern.
  • The term "small-cell variant of renal oncocytoma" was proposed for these cases.
  • The unusual extensive small-cell component of the tumor may represent a potential diagnostic pitfall for primary or metastatic malignant small cell tumors.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Small Cell / pathology. Cytoplasm / pathology. Kidney Neoplasms / pathology. Mitochondria / pathology
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Metastasis

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  • (PMID = 18074818.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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63. Kumamoto H, Ohki K, Ooya K: Expression of p63 and p73 in ameloblastomas. J Oral Pathol Med; 2005 Apr;34(4):220-6
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  • METHODS: Tissue specimens of nine tooth germs and 48 benign and five malignant ameloblastomas were examined by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) for the expression of p63 and p73.
  • RESULTS: Immunoreactivity for p63 and p73 was evident in epithelial cells neighboring the basement membrane in developing and neoplastic odontogenic tissues. p63 expression in desmoplastic ameloblastomas was significantly higher than in acanthomatous and granular cell ameloblastomas, and ameloblastic carcinomas showed higher p63 expression than metastasizing ameloblastomas. p73 expression was significantly higher in plexiform ameloblastomas than in follicular ameloblastomas, and basal cell ameloblastomas showed higher p73 expression than granular cell ameloblastomas. mRNA transcripts for Delta Np63 and TAp73 were detected in all developing and neoplastic odontogenic tissues.
  • [MeSH-major] Ameloblastoma / genetics. Apoptosis / genetics. DNA-Binding Proteins / genetics. Genes, Tumor Suppressor. Nuclear Proteins / genetics. Phosphoproteins / genetics. Trans-Activators / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Basement Membrane / metabolism. Cell Differentiation / genetics. Cell Proliferation. Epithelial Cells / metabolism. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry. Protein Isoforms / genetics. Reverse Transcriptase Polymerase Chain Reaction. Tooth Germ / metabolism. Transcription Factors. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 15752257.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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64. Atallah D, Rouzier R, Chamoun ML, Mansour F, Nabaa T, Chababi M, Duvillard P, Chahine G: Benign lipoblastomalike tumor of the vulva: report of a case affecting a young patient. J Reprod Med; 2007 Mar;52(3):223-4
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  • [Title] Benign lipoblastomalike tumor of the vulva: report of a case affecting a young patient.
  • BACKGROUND: Mesenchymal vulvar tumors are rare, and a benign lipoblastomalike tumor may be confused with malignancy.
  • After excision, histologic examination revealed a well-circumscribed and lobulated tumor.
  • The lobules were composed of slender spindle cells showing slightly eosinophilic cytoplasm with indistinct boundaries, uniform nuclei with finely granular chromatin and no nucleoli.
  • CONCLUSION: This mesenchymal tumor had adipocytic differentiation and no patent sign of malignancy, akin to infantile lipoblastoma.
  • Because of the benign behavior of this tumor, complete excision without radiation is recommended.
  • [MeSH-minor] Adolescent. Cell Division. Female. Humans. Immunohistochemistry. Treatment Outcome

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  • (PMID = 17465291.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Mohr U, Ernst H, Roller M, Pott F: Pulmonary tumor types induced in Wistar rats of the so-called "19-dust study". Exp Toxicol Pathol; 2006 Aug;58(1):13-20
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  • [Title] Pulmonary tumor types induced in Wistar rats of the so-called "19-dust study".
  • The incidences of primary lung tumor types histologically diagnosed in 28 groups of Wistar rats of the so-called "19-dust study" are described, the total study having been already presented by Pott and Roller (Carcinogenicity study with nineteen granular dusts in rats.
  • Eleven of the 13 dusts were classified as respirable granular bio-durable particles without known significant specific toxicity (abbreviation of the nine-word definition: GBP).
  • In 579 (58%) lungs of 1002 rats which survived more than 26 weeks after the first instillation of GBP, at least one primary lung tumor type was observed, and in 306 (31%) at least two types.
  • Three benign tumor types were diagnosed in the 579 tumor-bearing rats: bronchiolo-alveolar adenoma in 46%, cystic keratinizing epithelioma in 53%, and non-keratinizing epithelioma in 2.6% of the rats.
  • Two of three malignant tumor types (bronchiolo-alveolar carcinoma and squamous cell carcinoma) occurred in 46% and 31% of the tumor-bearing rats, respectively, and adenosquamous carcinoma was diagnosed in 0.9%.
  • Numerous lungs with a malignant tumor also showed one or more benign tumor types.
  • The proportionate incidences of the four predominantly diagnosed tumor types were compared with three summarized experimental groups which were exposed either to carbon black (two size classes), to titanium dioxide (two size classes), or to the total of the other nine GBP.
  • [MeSH-minor] Aluminum Oxide / toxicity. Aluminum Silicates / toxicity. Animals. Carbon / toxicity. Carcinoma, Adenosquamous / chemically induced. Carcinoma, Adenosquamous / pathology. Carcinoma, Squamous Cell / chemically induced. Carcinoma, Squamous Cell / pathology. Female. Intubation, Intratracheal. Particle Size. Rats. Rats, Wistar. Silicon Dioxide / toxicity. Specific Pathogen-Free Organisms. Titanium / toxicity

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  • [CommentIn] Exp Toxicol Pathol. 2007 Aug;58(6):407; author reply 409 [17560773.001]
  • (PMID = 16806863.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Aluminum Silicates; 0 / Dust; 15FIX9V2JP / titanium dioxide; 7440-44-0 / Carbon; 7631-86-9 / Silicon Dioxide; D1JT611TNE / Titanium; LMI26O6933 / Aluminum Oxide
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66. Schittenhelm J, Ebner FH, Harter P, Bornemann A: Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol; 2009;20(1):73-7
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  • Benign epithelial tumors are rarely found at this site.
  • The excised tumor was composed of nests of large polygonal cells with eosinophilic partial granular cytoplasm.
  • The tumor showed diffuse positivity for melan-A, synaptophysin, and alpha-inhibin.
  • Ultrastructural examination showed abundant mitochondria, suggesting an oncocytic tumor.
  • Immunohistochemistry excluded oncocytic paraganglioma, oncocytic meningioma, renal cell carcinoma, alveolar soft part sarcoma, and granular cell tumor.

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  • (PMID = 19039533.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Miron I, Miron L, Dumitraş S, Aprodu G, Ciobanu A, Tansanu I: [Statistical study of the evolution over ten years of the clinical and therapeutic approach in childhood soft tissue sarcoma]. Rev Med Chir Soc Med Nat Iasi; 2007 Apr-Jun;111(2):358-62
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  • Based on histological examination 19 cases (32.75%) were of rhabdomyosarcoma type with following subtypes: alveolar--7 patients, embryonic-- 9 cases, fusiform - 2 cases, bothrioid--1 case), 8 cases were undifferentiated soft tissue sarcomas and one patient had a tumor of pleiomorphic type; 13 children (22.41%) had non-rhabdomyosarcoma soft tissue sarcomas: 6 fibrosarcomas, 2 synovial sarcomas, 1 leiomyosarcoma, 1 Kaposi sarcoma, 1 case of malignant peripheral nerve sheath tumor, 1 case of angioma tumor, one liposarcoma; 16 cases were included in soft tissue tumors of uncertain origin (fibromatosis--6 cases, fibrous histiocytoma--4 cases, hamartoma--cases, myoblastoma--1 case, fibro-xanthoma--1 case, hemangioendothelioma--1 case); 1 PPNET (Askin tumor).

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  • (PMID = 17983168.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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68. Huang P, Staerkel G, Sneige N, Gong Y: Fine-needle aspiration of pancreatic serous cystadenoma: cytologic features and diagnostic pitfalls. Cancer; 2006 Aug 25;108(4):239-49
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  • BACKGROUND: The preoperative diagnosis of pancreatic serous cystadenoma (SCA) is important because as a typically benign tumor it can be treated expectantly, whereas many other cystic tumors require excision.
  • This study examines the cytology, clinical and radiologic features, diagnostic accuracy of fine-needle aspiration (FNA), and potential pitfalls associated with this rare tumor.
  • Aspirates were sparsely cellular against a clean or granular, proteinaceous background.
  • Tumor cells formed loose clusters or monolayered sheets composed of cuboidal cells with indistinct cell borders and granular or clear cytoplasm that was often stripped from the nucleus.
  • Seven (25%) of the aspirates were initially classified as "consistent with SCA," 6 (21%) as "no malignant cells," 3 (11%) as "nondiagnostic specimen," 3 (11%) as "suspicious for malignancy," 3 (11%) as "rare atypical cells," and 6 (21%) as "probably or consistent with mucinous cystic neoplasm."
  • Contaminating GI epithelium and mucin should be distinguished from components of a mucinous neoplasm.

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  • [Copyright] Copyright 2006 American Cancer Society.
  • (PMID = 16691573.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Stieglitz F, Kitz R, Schäfers HJ, Eickmeier O, Rose M, Fellbaum C, Zielen S: Granular cell tumor of the trachea in a child. Ann Thorac Surg; 2005 Feb;79(2):e15-6
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  • [Title] Granular cell tumor of the trachea in a child.
  • Granular cell tumors are uncommon benign neoplasms.
  • We present the case of a 14-year-old girl with a granular cell tumor of the trachea.
  • The tumor was incidentally found at bronchoscopy performed to exclude suspected foreign body aspiration.
  • Biopsies revealed the histologic pattern of a benign granular cell tumor.
  • She has not had any recurrence of the tumor during 3 years of follow-up.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Granular Cell Tumor / surgery. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / surgery

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  • (PMID = 15680798.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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70. Eandi JA, Asuncion A, Vandewalker KN, Javidan J: Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma. Int J Urol; 2007 Sep;14(9):862-4
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  • [Title] Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma.
  • Granular cell tumor of the bladder is exceptionally rare, with only 11 cases reported in the published reports.
  • Pseudoepitheliomatous hyperplasia of the overlying squamous epithelium has been observed in non-bladder granular cell tumors.
  • We herein report the first case of bladder granular cell tumor to exhibit pseudoepitheliomatous hyperplasia.
  • This phenomenon is significant as it may potentially lead to difficulty in the distinction between infiltrative squamous cell carcinoma and pseudoepitheliomatous hyperplasia in cases of granular cell tumor of the bladder.
  • This case also represents the first granular cell tumor to demonstrate colocalization with adenocarcinoma of the bladder.
  • Based on our findings and a review of the published reports, management for granular cell tumor of the bladder should involve a course of local resection combined with active surveillance given its typical benign course, albeit with the potential for local recurrence.
  • [MeSH-major] Adenocarcinoma / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17760758.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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71. Torrijos-Aguilar A, Alegre-de Miquel V, Pitarch-Bort G, Mercader-García P, Fortea-Baixauli JM: [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases]. Actas Dermosifiliogr; 2009 Mar;100(2):126-32
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  • [Title] [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases].
  • [Transliterated title] Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos.
  • BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells.
  • OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature.
  • METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases).
  • CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
  • [MeSH-major] Granular Cell Tumor / epidemiology. Mouth Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Child, Preschool. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Female. Fibroma / diagnosis. Humans. Male. Middle Aged. Retrospective Studies. Skin Neoplasms / chemistry. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Staining and Labeling. Young Adult

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  • (PMID = 19445877.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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72. Meyer MA, Becker JM, Quinones W: Endobronchial granular cell tumor: a case report. J Radiol Case Rep; 2010;4(8):29-35
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  • [Title] Endobronchial granular cell tumor: a case report.
  • Granular cell tumors (GCTs) are benign neoplasms that are most commonly found in the head and neck region.
  • We present a case of endobronchial granular cell tumor presenting as hemoptysis in a 22-year-old African American female.

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  • (PMID = 22470750.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303395
  • [Keywords] NOTNLM ; Granular cell tumor / endobronchial
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73. Cheewakriangkrai C, Sharma S, Deeb G, Lele S: A rare female genital tract tumor: benign granular cell tumor of vulva: case report and review of the literature. Gynecol Oncol; 2005 May;97(2):656-8
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  • [Title] A rare female genital tract tumor: benign granular cell tumor of vulva: case report and review of the literature.
  • BACKGROUND: The granular cell tumor (GCT) of vulva is a rare female genital tract tumor.
  • Histologic examination of the tumor showed sheets and clusters of infiltrating tumor cells with morphologic features consistent with granular cell tumor.
  • CONCLUSION: Although benign and slow growing, it has a tendency for recurrence and can cause morbidity and mortality when presenting with multicentric or multiple organ involvement due to the lack of effective systemic therapy.
  • [MeSH-major] Granular Cell Tumor / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 15863174.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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74. Arai E, Nishida Y, Tsukushi S, Sugiura H, Ishiguro N: Intramuscular granular cell tumor in the lower extremities. Clin Orthop Relat Res; 2010 May;468(5):1384-9
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  • [Title] Intramuscular granular cell tumor in the lower extremities.
  • Granular cell tumors are uncommon but typically histologically benign neoplasms that occasionally behave as malignant tumors.
  • Differentiation of benign granular cell tumors from malignant counterparts with radiographic and/or histologic analysis is crucial for physicians.
  • We retrospectively studied five cases of intramuscular granular cell tumors arising in the lower extremities.
  • All tumors had been histologically diagnosed as benign and were resected with a wide surgical margin.
  • Intramuscular granular cell tumors can be diagnosed based on their characteristic MRI features, such as peripheral high intensity on T2-weighed images, and histologic evaluation.
  • The histologic criteria described by Fanburg-Smith et al. can differentiate malignant granular cell tumors from benign tumors.
  • A wide resection seems suitable for most granular cell tumors in the extremities.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Leg

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  • [Cites] Clin Orthop Relat Res. 2000 Nov;(380):191-8 [11064991.001]
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  • (PMID = 19760336.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853648
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75. Dudrap E, Lemierre G, Auquit-Auckbur I, Courville P, Milliez PY: [Abrikossoff's tumor: about one case of inter-mammary cutaneous localization and review of literature]. Ann Chir Plast Esthet; 2008 Dec;53(6):521-5
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  • [Title] [Abrikossoff's tumor: about one case of inter-mammary cutaneous localization and review of literature].
  • SUBJECT: Our report concerns a large inter-mammary cutaneous Abrikossoff tumor on a 41-year-old female patient, which has prompted us to review the literature.
  • CASE: It was a low pre-sternal skin tumor; CT-Scanning showed a homogeneous mass 5 cm high, 4 cm wide and 4 cm deep.
  • DISCUSSION: Abrikossoff tumors (or granular cell tumors) are rare ubiquity tumors locating preferably in ENT and oral cavity mucosa.
  • They are overwhelmingly single and benign but on occasion multifocal or malignant.
  • [MeSH-major] Granular Cell Tumor / surgery. Skin Neoplasms / surgery

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  • (PMID = 18541358.001).
  • [ISSN] 1768-319X
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 14
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76. Luzar B, Calonje E: Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: a review. J Cutan Pathol; 2010 Mar;37(3):301-9
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  • Additional changes were hemorrhagic and pseudoangiomatous areas (24.2%), granular cell change (22.7%), keloid-like areas (9.1%), myxoid change (7.6%), osteoclast-like giant cells (6.1%) and clear cell change (4.6%).
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Arm / pathology. Biomarkers, Tumor. Diagnosis, Differential. Female. Fibrosis / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Scalp / pathology. Sex Factors


77. Denayer E, Devriendt K, de Ravel T, Van Buggenhout G, Smeets E, Francois I, Sznajer Y, Craen M, Leventopoulos G, Mutesa L, Vandecasseye W, Massa G, Kayserili H, Sciot R, Fryns JP, Legius E: Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations. Genes Chromosomes Cancer; 2010 Mar;49(3):242-52
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  • [Title] Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations.
  • One was classified as a rare benign variant and the other remains unclassified.
  • Three patients with SOS1 mutations presented with tumors (embryonal rhabdomyosarcoma, Sertoli cell testis tumor, and granular cell tumors of the skin).
  • One patient with a RAF1 mutation had a lesion suggestive for a giant cell tumor.
  • This is the first report describing different tumor types in NS patients with germ line SOS1 mutations.


78. Epstein DS, Pashaei S, Hunt E Jr, Fitzpatrick JE, Golitz LE: Pustulo-ovoid bodies of Milian in granular cell tumors. J Cutan Pathol; 2007 May;34(5):405-9
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  • [Title] Pustulo-ovoid bodies of Milian in granular cell tumors.
  • BACKGROUND: Granular cell tumors (GCTs) are benign neural tumors with a distinct histologic appearance on light microscopy, characterized by eosinophilic cytoplasmic granules.
  • METHODS: We examined the sections of 47 cases of GCT stained with hematoxylin and eosin to determine the frequency of POB within this tumor.
  • When grouped according to clinical characteristics, there was an even distribution of POB by age, sex and site of the tumor.
  • [MeSH-major] Granular Cell Tumor / pathology. Inclusion Bodies / pathology. Skin Neoplasms / pathology

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  • (PMID = 17448196.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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79. Policarpio-Nicolas ML, Abbott TE, Dalkin AC, Bennett-Wick J, Frierson HF Jr: Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature. Diagn Cytopathol; 2008 Feb;36(2):115-9
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  • [Title] Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature.
  • Oncogenic (tumor-induced) osteomalacia is a rare paraneoplastic syndrome of phosphate wasting that is frequently associated with phosphaturic mesenchymal tumor (PMT).
  • As the cytologic features of this tumor apparently have not been reported, we describe the fine-needle aspiration (FNA) findings for PMT that arose from the gluteal soft tissue in a patient with hypophosphatemia and multiple fractures secondary to osteomalacia.
  • Smears from the computerized tomography (CT)-guided FNA showed groups of spindle cells having elongated nuclei, fine to moderately coarsely granular chromatin, inconspicuous nucleoli, and delicate cytoplasm.
  • The differential diagnosis included a variety of benign and malignant spindle cell neoplasms such as monophasic synovial sarcoma, leiomyoma, peripheral nerve sheath tumor, fibrosarcoma, and, less likely, metastatic melanoma and sarcomatoid carcinoma.
  • The bland-appearing cytologic features of a spindle cell tumor in a patient with osteomalacia should suggest the diagnosis of PMT.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181193.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphates
  • [Number-of-references] 21
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80. Wang Y, Li X, Guo Y, Chan L, Guan X: alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism; 2010 Jul;59(7):967-76
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  • In addition, metabolic action and cellular signaling of LA were studied in cultured mouse myoblastoma C2C12 cells.

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  • (PMID = 20015518.001).
  • [ISSN] 1532-8600
  • [Journal-full-title] Metabolism: clinical and experimental
  • [ISO-abbreviation] Metab. Clin. Exp.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K01 DK075489-04; United States / NIDDK NIH HHS / DK / R03 DK084125; United States / NHLBI NIH HHS / HL / R01 HL051586; United States / NHLBI NIH HHS / HL / HL51586; United States / NIDDK NIH HHS / DK / DK075489-04S1; United States / NHLBI NIH HHS / HL / R01 HL051586-12; United States / NIDDK NIH HHS / DK / K01 DK075489-01; United States / NHLBI NIH HHS / HL / HL051586-12; United States / NIDDK NIH HHS / DK / R03 DK084125-02; United States / NIDDK NIH HHS / DK / DK075489-04; United States / NIDDK NIH HHS / DK / DK075489-01; United States / NIDDK NIH HHS / DK / K01 DK075489-04S1; United States / NIDDK NIH HHS / DK / 5K01DK75489; United States / NIDDK NIH HHS / DK / K01 DK075489; United States / NIDDK NIH HHS / DK / DK084125-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Fatty Acids; 0 / Ppargc1a protein, mouse; 0 / Trans-Activators; 0 / Transcription Factors; 47E5O17Y3R / Phenylalanine; 63231-63-0 / RNA; 73Y7P0K73Y / Thioctic Acid; 9G2MP84A8W / Deoxyglucose; EC 2.7.11.11 / Cyclic AMP-Dependent Protein Kinases
  • [Other-IDs] NLM/ NIHMS166156; NLM/ PMC2882509
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81. Lerman M, Freedman PD: Nonneural granular cell tumor of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar;103(3):382-4
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  • [Title] Nonneural granular cell tumor of the oral cavity: a case report and review of the literature.
  • Nonneural granular cell tumors (NNGCTs) are rare benign neoplasms originally described in 1991 by Leboit et al.
  • Typical granular cell tumors (GCTs) are commonly encountered in the oral cavity, but NNGCTs, unlike GCTs, are S-100 negative and may display cytologic atypia, allowing for misdiagnosis as a more aggressive lesion.
  • [MeSH-major] Granular Cell Tumor / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17321450.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD63 protein, human; 0 / CD68 antigen, human; 0 / Platelet Membrane Glycoproteins
  • [Number-of-references] 9
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82. Armah HB, Parwani AV: Perivascular epithelioid cell tumor. Arch Pathol Lab Med; 2009 Apr;133(4):648-54
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  • [Title] Perivascular epithelioid cell tumor.
  • Perivascular epithelioid cell tumors are mesenchymal neoplasms defined by the presence of histologically and immunohistochemically distinctive perivascular epithelioid cells.
  • The perivascular epithelioid cell has no known normal tissue counterpart and coexpresses myoid and melanocytic markers.
  • This tumor family shows marked female predominance and includes angiomyolipoma, clear cell sugar tumor, lymphangioleiomyomatosis, and a group of rare, morphologically and immunophenotypically similar tumors arising at a variety of visceral and soft tissue sites.
  • This latter subset has been collectively termed perivascular epithelioid cell tumors-not otherwise specified.
  • They are usually composed of epithelioid, but occasionally spindled, cells with clear to granular eosinophilic cytoplasm and focal perivascular accentuation.
  • Although most cases are benign, a subset behaves in a malignant fashion.
  • This review focuses on the perivascular epithelioid cell tumors-not otherwise specified subset.
  • [MeSH-major] Perivascular Epithelioid Cell Neoplasms. Soft Tissue Neoplasms

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  • (PMID = 19391667.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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83. Zhao YC, Li NY, Zhou XJ, Zhou HB, Ma HH, Zhang RS: [Clinicopathologic study of pilocytic astrocytoma]. Zhonghua Bing Li Xue Za Zhi; 2008 Sep;37(9):609-14
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  • Cystic degeneration was noted in 41 cases (60.3%), and enhancement of the tumor was noted in 43 cases (87.8%).
  • Total tumor excision was performed in 35 patients, subtotal tumor excision was performed in 31 patients, and the procedures of other 2 patients were not clear.
  • Among 51 patients with follow-up information, 44 were alive, 7 had recurrent tumor, and 7 died.
  • Tumors with classic histopathology demonstrated biphasic pattern of growth, consisting of compact elongated bipolar astrocytes associated with rosenthal fibers, and less cellular areas of multipolar cells with granular bodies and microcyst.
  • All cases showed diffuse positive staining for GFAP and low expression for Ki-67, except 1 anaplastic tumor with 10% Ki-67 indices.
  • CONCLUSIONS: PA is a benign, WHO grade I tumor with favorable prognosis, and does not require radiotherapy after total resection.
  • The tumor can be mistaken as higher-grade astrocytoma when involving the subarachnoid space, and with cytological atypia, leading to unnecessary radiotherapy after surgery.
  • The outcome for patients with brainstem tumor or anaplastic PA is poor.
  • [MeSH-minor] Cell Nucleus / pathology. Female. Humans. Male. Prognosis. Treatment Outcome

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  • (PMID = 19094585.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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84. Kapur P, Rakheja D, Balani JP, Roy LC, Amirkhan RH, Hoang MP: Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors. Arch Pathol Lab Med; 2007 Jan;131(1):57-64
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  • [Title] Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors.
  • CONTEXT: Granular cell tumors (GCTs) are classified as benign when none of the following features is present: spindling of the tumor cells, necrosis, diffuse pleomorphism, prominent nucleoli, high nuclear-cytoplasmic ratio, and mitotic rate >2 per 10 high-power fields.
  • OBJECTIVE: To compare immunohistochemical staining for phosphorylated histone H3 (PHH3), Ki-67 (MIB-1), p21, fatty acid synthase, and cleaved caspase-3 in histologically classified benign and atypical GCTs.
  • The expression of p21, fatty acid synthase, and cleaved caspase-3 was not significantly different between atypical and benign GCTs.
  • [MeSH-major] Caspase 3 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Fatty Acid Synthases / metabolism. Granular Cell Tumor / metabolism. Histones / metabolism. Ki-67 Antigen / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry / methods. Male. Middle Aged. Mitosis. Necrosis / pathology. Phosphorylation. Retrospective Studies

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  • (PMID = 17227124.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Histones; 0 / Ki-67 Antigen; EC 2.3.1.85 / Fatty Acid Synthases; EC 3.4.22.- / Caspase 3
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85. Arican O, Ciralik H, Sasmaz S: Multiple plaques on the back: S-100 negative benign granular cell tumor. J Dermatol; 2005 Jul;32(7):585-8
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  • [Title] Multiple plaques on the back: S-100 negative benign granular cell tumor.
  • Granular cell tumor is a rarely seen disease characterized by a gradually developing nodular lesion, which is difficult to diagnose.
  • The tumor usually appears in the 4th-6th decades of life, more frequently in women and blacks, and has a multifocal location in 10-25% of the cases.
  • The present paper describes an 18-year-old female patient with benign granular cell tumor.
  • This rarely seen type of tumor was S-100 negative and has been detected in biopsies taken from multiple asymptomatic plaques and maculopapular lesions.
  • [MeSH-major] Granular Cell Tumor / pathology. S100 Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 16335876.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / S100 Proteins
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86. Miyake M, Tateishi U, Maeda T, Arai Y, Hasegawa T, Sugimura K: Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT. Radiat Med; 2006 Feb;24(2):154-7
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  • [Title] Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT.
  • Bronchial granular cell tumor is an uncommon benign tumor that causes pulmonary complications due to obstruction of the airways.
  • [MeSH-major] Bronchial Neoplasms / complications. Granular Cell Tumor / complications. Lung Diseases, Obstructive / etiology

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  • (PMID = 16715680.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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87. Thillaikarasi R, Balaji J, Gupta B, Ilayarja V, Vani NV, Vidula B, Saravanan B, Ponniah I: Cystic granular cell ameloblastoma. J Maxillofac Oral Surg; 2010 Sep;9(3):310-3
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  • [Title] Cystic granular cell ameloblastoma.
  • Ameloblastoma is a locally aggressive benign epithelial odontogenic tumor, while unicystic ameloblastoma is a relatively less aggressive variant.
  • Although rare in unicystic or cystic ameloblastoma, granular cell change in ameloblastoma is a recognized phenomenon.
  • The purpose of the present article is to report a case of cystic granular cell ameloblastoma in 34-year old female.

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  • (PMID = 22190813.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177435
  • [Keywords] NOTNLM ; Ameloblastoma / Cystic / Granular cell / Odontogenic
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88. Bekteshi E, Toth JW, Benninghoff MG, Kang J, Betancourt M: Granular cell tumor of trachea. J Bronchology Interv Pulmonol; 2009 Jan;16(1):68-9
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  • [Title] Granular cell tumor of trachea.
  • Granular cell tumors of the tracheobronchial tree are rare benign lesions of neurogenic origin.
  • These benign tumors mostly involve the skin, oral cavity, or esophagus.
  • There is no consensus regarding treatment of granular cell tumors.

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  • (PMID = 23168477.001).
  • [ISSN] 1944-6586
  • [Journal-full-title] Journal of bronchology & interventional pulmonology
  • [ISO-abbreviation] J Bronchology Interv Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Novakov-Mikić A, Ivanović L, Lucić M, Kiralj A, Koprivsek K, Vucković N: [Prenatal diagnosis of granular cell myoblastoma--a case report]. Med Pregl; 2006 Nov-Dec;59(11-12):573-6
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  • [Title] [Prenatal diagnosis of granular cell myoblastoma--a case report].
  • INTRODUCTION: The aim of this paper is to present a case of prenatal diagnosis of a congenital tumor of the oral cavity diagnosed at 28 weeks of gestation.
  • CASE REPORT: After the diagnosis of oral cavity tumor was made by 21) ultrasound, a 3D scan was performed, which confirmed the diagnosis revealing a peduncle at the upper border of maxilla.
  • Magnetic resonance imaging was performed, confirming the diagnosis and the site of the tumor.
  • Regular three-week follow-up scans were performed to follow the growth of the tumor, as well as the state of the amniotic fluid.
  • No tumor growth was detected, and the amniotic fluid volume was normal until 39 weeks of gestation.
  • Cesarean section was scheduled, due to the risk of tumor disruption during a vaginal delivery.
  • The histopathological diagnosis was: granular cell myoblastoma.
  • The female newborn was developing normally, and at 5 months of age there were no traces of scarring at the place of the tumor.
  • [MeSH-major] Granular Cell Tumor / congenital. Mouth Neoplasms / congenital. Mouth Neoplasms / diagnosis

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  • (PMID = 17633900.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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90. Wolfe SQ, Bruce J, Morcos JJ: Pituicytoma: case report. Neurosurgery; 2008 Jul;63(1):E173-4; discussion E174
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  • To date, we have found only 28 cases reported in the literature and have reviewed these in addition to our own case to delineate the clinical implications of this relatively recently defined tumor.
  • CLINICAL PRESENTATION: A 71-year-old woman presented with bitemporal hemianopsia and was found to have a large sellar tumor, resembling a pituitary adenoma.
  • Transsphenoidal resection was attempted but was complicated by significant tumor vascularity.
  • Pathology at that time was interpreted as a "granular cell tumor."
  • The patient was then referred to our institution for management of the residual tumor.
  • INTERVENTION: The patient underwent preoperative embolization to decrease tumor vascularity, and subtotal tumor resection was performed via a craniofacial approach.
  • Postoperatively, the patient has enjoyed significantly improved visual fields despite residual tumor.
  • There has been no regrowth of the residual tumor, as shown on magnetic resonance imaging, over a follow-up period of 1.5 years.
  • CONCLUSION: Pituicytomas are benign, slow-growing tumors that seem to be cured by gross total resection.
  • We advocate an aggressive surgical approach with possible preoperative embolization to reduce the vascularity of the tumor.

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  • (PMID = 18728556.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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91. Thamboo TP, Tan LH, Tan SY: Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. J Cutan Pathol; 2006 Jan;33(1):27-32
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  • [Title] Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors.
  • Little is known about the expression of Bcl-x in cutaneous adnexal structures and benign cutaneous adnexal tumors.
  • METHODS: Tissues from 31 cases of benign cutaneous adnexal tumors (five trichofolliculomas, five trichoepitheliomas, two sebaceous adenomas, five apocrine hidradenomas, five eccrine poromas, five eccrine spiradenomas, and four syringomas) were immunostained for Bcl-x.
  • RESULTS: Strong staining for Bcl-x was seen in cells of the epidermal granular layer and inner root sheath of hair follicles.
  • CONCLUSIONS: The degree of Bcl-x expression in cutaneous adnexal glandular structures appears to be related to their mode of secretion, being strongest in cells with apoptotic degradation of the entire cell (sebocytes).
  • This pattern is recapitulated in the corresponding benign cutaneous adnexal tumors.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epidermis / metabolism. Epidermis / pathology. Humans. Immunoenzyme Techniques. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 16441408.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / bcl-X Protein
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92. Pu RT, Yang J, Wasserman PG, Bhuiya T, Griffith KA, Michael CW: Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration? Diagn Cytopathol; 2006 May;34(5):330-4
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  • [Title] Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration?
  • The diagnosis of an adequately sampled thyroid FNA is generally grouped into three categories: benign, malignant, and indeterminate.
  • The latter group usually includes follicular neoplasm, follicular lesion, and sometimes a more specific diagnosis such as Hurthle cell neoplasm or follicular lesion/neoplasm with Hurthle cell change.
  • Whether a FNA diagnosis of Hurthle cell lesion/neoplasm (HLN) denotes a worse clinical outcome than follicular lesion/neoplasm (FLN) remains controversial.
  • Upon excision, the FNA diagnosis of HLN group had 14 cases of goiter/nodular hyperplasia (16%), 46 cases of adenoma (12 follicular adenoma (14%) and 34 cases of Hurthle cell adenoma (39%)), and 27 cases of carcinoma (31%, 12 papillary carcinoma and 15 Hurthle cell carcinoma).
  • The FLN group had 74 cases of goiter/nodular hyperplasia (34.3%), 8 cases of Hashimoto thyroiditis (3.7%), 73 cases of follicular adenoma (33.8%), one case of granular cell tumor, and 60 cases of carcinoma (27.8%, 46 papillary carcinoma, 12 follicular carcinoma, and 1 Hurthle cell carcinoma and 1 parathyroid carcinoma) upon excision.
  • Hurthle cell carcinoma patients are typically older than patients with other cancer diagnoses (59 versus 44, P = 0.0077).
  • Males and older patients with a HLN FNA diagnosis carry a higher risk of Hurthle cell carcinoma upon thyroidectomy.

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  • (PMID = 16604553.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Collins BT, Phillips NJ, Hsueh EC: Fine needle aspiration biopsy of splenic hamartoma with bizarre stromal cells: a case report. Acta Cytol; 2008 May-Jun;52(3):347-50
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  • BACKGROUND: Splenic hamartoma is a rare benign "tumor" with disorganized red pulp tissue without white pulp elements.
  • Cell fragments possessed a variable proportion of spindle to ovoid cells.
  • The bizarre large cells had single or multiple round, oval or distorted nuclei with granular chromatin.
  • Cell block mirrored the smear pattern, and the bizarre large cells were negative by immunohistochemistry.
  • Malignant spindle cell neoplasm was favored.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged. Vimentin / metabolism

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  • (PMID = 18540303.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
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94. Eriksen JR, Ibsen PH, Gyrtrup HJ: [Granular cell tumor of the colon--Abrikossoff's tumor]. Ugeskr Laeger; 2006 May 22;168(21):2080-1
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  • [Title] [Granular cell tumor of the colon--Abrikossoff's tumor].
  • [Transliterated title] Granularcelletumor i colon--Abrikossoffs tumor.
  • Histopathologic examination of the specimen showed a tubulovillous adenoma with moderate dysplasia and an adjacent 1 x 1 cm submucosal tumor classified as a benign GCT due to the appearance in the light microscope and immunohistochemical analysis.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 16768929.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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95. Haikal F, Maceira J, Dias E, Ramos-E-Silva M: Histogenesis of Abrikossoff tumour of the oral cavity. Int J Dent Hyg; 2010 Feb;8(1):53-62
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  • BACKGROUND: Abrikossoff or granular cell tumour (GCT) is a relatively rare neoplasia, benign in most of the cases.
  • MATERIALS AND METHODS: Samples of tissues from the oral mucosa, tongue and lips placed in paraffin blocks, from eleven patients with a histopathological diagnosis of benign GCT were studied.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Cytoplasm / pathology. Female. Humans. Hyperplasia. Immunohistochemistry. Lip Neoplasms / pathology. Male. Middle Aged. Mouth Mucosa / pathology. Neuroendocrine Cells / pathology. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis. Schwann Cells / pathology. Tongue Neoplasms / pathology. Ubiquitin Thiolesterase / analysis. Vimentin / analysis. Young Adult

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  • (PMID = 20096083.001).
  • [ISSN] 1601-5037
  • [Journal-full-title] International journal of dental hygiene
  • [ISO-abbreviation] Int J Dent Hyg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase; EC 4.2.1.11 / Phosphopyruvate Hydratase
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96. Caltabiano R, Cappellani A, Di Vita M, Lanzafame S: The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. J Craniofac Surg; 2008 Nov;19(6):1691-4
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  • [Title] The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study.
  • We report a case of a 47-year-old man with a granular cell tumor (GCT) of the tongue colocalized with a squamous cell carcinoma.
  • Furthermore, we performed an immunohistochemical analysis with p63 to distinguish pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma.
  • Clinicians and pathologists must be made aware of this potential diagnostic pitfall so that the workup of a tongue lesion does not end prematurely with a benign diagnosis of granular cell tumor with overlying pseudoepitheliomatous hyperplasia.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Epithelium / pathology. Follow-Up Studies. Humans. Hyperplasia. Immunohistochemistry. Male. Membrane Proteins / analysis. Middle Aged. Mouth Mucosa / pathology. Neoplasm Invasiveness. S100 Proteins / analysis

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  • (PMID = 19098584.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins
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97. Huang W, Kanehira K, Drew S, Pier T: Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):12-7
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  • [Title] Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study.
  • BACKGROUND: Differentiating oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation.
  • DESIGN: A renal cell neoplasm tissue microarray was constructed including oncocytoma (n=30), chromophobe RCC (n=18), conventional RCC (n=64), papillary RCC (n=50), and benign renal tissues (n=31).
  • CK7, CD10, epithelial membrane antigen, renal cell carcinoma marker (RCCma), vimentin, and endogenous avidin-binding activity (EABA) were studied.
  • RESULT: EABA was positive in 97% of oncocytoma, 26% of conventional RCC and 35% of papillary RCC with granular/eosinophilic (G/E) features and 6% of chromophobe RCC.

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  • (PMID = 18769342.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Vimentin; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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98. Kondo T, Kajimoto S, Okuda H, Toma H, Tanabe K: A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. Int J Urol; 2006 Jun;13(6):827-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery.
  • Granular cell tumor is a benign neoplasm which frequently occurs in the oral cavity, skin, and subcutaneous tissue.
  • Granular cell tumor of the bladder is an extremely rare disease, and only nine cases have been reported.
  • We present here an additional case of granular cell tumor occurring in the bladder.
  • Unlike the other tumors reported, this tumor extruded into the Retzius' cavity.
  • Therefore, the tumor was successfully excised through extraperitoneal laparoscopic surgery.
  • The small tumor located in Retzius' cavity could be managed with extraperitoneal laparoscopic surgery.
  • [MeSH-major] Granular Cell Tumor / therapy. Laparoscopy. Urinary Bladder Neoplasms / therapy

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  • (PMID = 16834673.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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99. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG: A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg; 2005 Feb;102(2):256-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: This is a retrospective review of 146 surgically treated benign and malignant peripheral non-neural sheath tumors (PNNSTs).
  • Tumor classifications with patient numbers, locations of benign PNNSTs, and surgical techniques and adjunctive treatments are presented.
  • The results of a literature review regarding tumor frequencies are presented.
  • METHODS: One hundred forty-six patients with 111 benign and 35 malignant PNNSTs were treated between 1969 and 1999 at the Louisiana State University Health Sciences Center (LSUHSC).
  • The benign tumors included 33 ganglion cysts, 16 cases of localized hypertrophic neuropathy, 12 lipomas, 12 tumors of vascular origin, and 11 desmoid tumors.
  • There were four each of lipofibrohamartomas, myositis ossificans, osteochondromas, and ganglioneuromas; two each of meningiomas, cystic hygromas, myoblastoma or granular cell tumors, triton tumors, and lymphangiomas; and one epidermoid cyst.
  • The locations of benign PNNSTs were the following: 33 in the brachial plexus region, 39 in an upper extremity, one in the pelvic plexus, and 38 in a lower extremity.
  • There were two melanomas metastatic to nerve and one tumor each that had metastasized from the bladder, rectum, skin, head and neck, and thyroid, and from a primary Ewing sarcoma.
  • CONCLUSIONS: There were more benign PNNSTs than malignant ones.
  • Benign tumors were relatively equally distributed in the brachial plexus region and upper and lower extremities, with the exception of the pelvic plexus, which had only one tumor.

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  • (PMID = 15739553.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Rekhi B, Jambhekar NA: Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center. Ann Diagn Pathol; 2010 Jun;14(3):162-7
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  • [Title] Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center.
  • A granular cell tumor (GCT) is relatively uncommon and objectively diagnosed with neural markers on immunohistochemistry (IHC).
  • Herein, we present morphologic spectrum of 12 GCTs of soft tissues and skin, including 10 benign and 2 malignant subtypes with an optimal diagnostic IHC panel.
  • Cytologic smears in 2 cases displayed polygonal cells with abundant, eosinophilic, granular cytoplasm.
  • On histopathology, all cases invariably revealed a nonencapsulated infiltrating tumor comprising groups and nests of granular cells with vesicular nuclei.
  • In 5 cases, granular cells were noted in close proximity to the nerves.
  • Immunohistochemistry in 10 cases (83.3%) showed diffuse S-100 positivity in all 7 benign and 2 malignant cases: cytoplasmic CD68 positivity (all 10 cases) and membranous vimentin staining (all 4 cases).
  • A GCT is a discrete tumor entity and can be identified from other granular lesions by its proximity to nerves and objective identification with diffuse S-100 positivity, CD68 positivity, and membranous vimentin positivity that form an optimal IHC panel in limited resource settings, irrespective of benign or malignant types.
  • [MeSH-major] Cancer Care Facilities. Granular Cell Tumor / pathology. Referral and Consultation. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Biomarkers, Tumor / metabolism. Child. Female. Humans. Male. Middle Aged. S100 Proteins / metabolism. Vimentin / metabolism. Young Adult

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  • (PMID = 20471560.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / S100 Proteins; 0 / Vimentin
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