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1. Niedzielska I, Sypniewski D, Mazurek U, Wilczok T, Niedzielski Z, Wziatek-Kuczmik D: Differential diagnosis of gingival hyperplasia based on IFN-gamma-stimulated gene expression using RT-PCR. Folia Biol (Praha); 2007;53(1):23-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential diagnosis of gingival hyperplasia based on IFN-gamma-stimulated gene expression using RT-PCR.
  • Epulus is a benign gingival tumour of unknown aetiopathogenesis.
  • The literature does not present any molecular analysis of the tumour characteristics.
  • The purpose of the present study was to compare benign (epulus) and malignant (cancer) gingival hyperplasias with regard to the activity of the genes of apoptosis, proliferation, and inflammation using RT-PCR.
  • The investigation involved 70 patients with epuli and 15 patients with gingival squamous cell carcinoma.
  • Each subject had specimens collected from the tumour, tissue margin (incision line), and healthy tissue.
  • Correlations have been disclosed between apoptosis and proliferation genes expression in giant cell epuli and high-differentiated gingival squamous cell carcinoma.
  • In RT-PCR molecular analysis, giant cell epulus shows characteristics of a neoplastic lesion, while other epulus types seem to be inflammatory tumours.
  • [MeSH-major] Gene Expression Regulation, Neoplastic / drug effects. Gingival Hyperplasia / diagnosis. Gingival Hyperplasia / genetics. Interferon-gamma / pharmacology
  • [MeSH-minor] Diagnosis, Differential. Gene Expression Profiling. Humans. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17328839.001).
  • [ISSN] 0015-5500
  • [Journal-full-title] Folia biologica
  • [ISO-abbreviation] Folia Biol. (Praha)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 82115-62-6 / Interferon-gamma
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2. Eguia A, Uribarri A, Gay Escoda C, Crovetto MA, Martínez-Conde R, Aguirre JM: Granular cell tumor: report of 8 intraoral cases. Med Oral Patol Oral Cir Bucal; 2006 Aug;11(5):E425-8
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  • [Title] Granular cell tumor: report of 8 intraoral cases.
  • Granular cell tumor (GCT) is an uncommon neoplasm of controversial origin that can appear in any corporal localization, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most of GCTs are benign.
  • In spite of the amount of research, the etiology of this neoplasm remains unclear and its histogenesis and its possible muscular, connective or neural origin has been broadly debated.
  • The main clinicopathologic and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Gingival Neoplasms / pathology. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16878061.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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3. Colombo P, Tondulli L, Masci G, Muzza A, Rimassa L, Petrella D, Santoro A: Oral ulcer as an exclusive sign of gastric cancer: report of a rare case. BMC Cancer; 2005;5:117
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  • [Title] Oral ulcer as an exclusive sign of gastric cancer: report of a rare case.
  • BACKGROUND: The oral cavity is a rare but occasional target for metastases, which may masquerade as various benign and inflammatory lesions, and sometimes also be asymptomatic.
  • CASE PRESENTATION: We here describe an uncommon case of a hard palate mucosa and gingival metastasis from gastric carcinoma that was originally diagnosed as a periodontal disease.
  • Histopathological examination of a biopsy of the lesion revealed a signet-ring cell carcinoma, and a subsequent biopsy of an ulcerated stomach lesion showed a poorly differentiated gastric carcinoma.
  • The patient underwent gastric resection but died of heart failure on the tenth postoperative day; a post-mortem examination revealed a residual bilateral ovarian infiltration by gastric carcinoma (Krukenberg's tumor).
  • CONCLUSION: An occult carcinoma of the stomach may rarely metastasise to the oral cavity even as a first and exclusive manifestation; it is important to bear this possibility in mind because such conditions may mimic a benign disease.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / pathology. Gingival Neoplasms / secondary. Mouth / pathology. Mouth Neoplasms / secondary. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Ulcer / pathology
  • [MeSH-minor] Biopsy. Carcinoma / pathology. Cell Differentiation. Fatal Outcome. Female. Humans. Immunohistochemistry. Middle Aged. Mouth Mucosa / pathology. Neoplasm Metastasis. Palate, Hard / pathology

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  • (PMID = 16171522.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1242220
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4. Ababneh KT: Biopsied gingival lesions in northern Jordanians: A retrospective analysis over 10 years. Int J Periodontics Restorative Dent; 2006 Aug;26(4):387-93
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  • [Title] Biopsied gingival lesions in northern Jordanians: A retrospective analysis over 10 years.
  • The frequency and distribution of 183 consecutive cases of biopsied gingival lesions from northern Jordanians are presented here.
  • Neoplasms accounted for 9% of biopsies (7% benign, 3% malignant).
  • The most frequent neoplasm was peripheral ossifying fibroma.
  • The maximum number of benign neoplasms occurred in patients aged 20 to 39 years, and malignant neoplasms did not occur in patients younger than 30 years.
  • The frequency and distribution of gingival lesions in north Jordan are similar to those found in other countries.
  • Additional nationwide multicenter studies are needed to describe all aspects of epidemiology of gingival lesions in Jordan.
  • [MeSH-major] Biopsy / statistics & numerical data. Gingival Diseases / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / epidemiology. Child. Female. Fibroma, Ossifying / epidemiology. Gingival Hyperplasia / epidemiology. Gingival Neoplasms / epidemiology. Granuloma, Giant Cell / epidemiology. Granuloma, Pyogenic / epidemiology. Humans. Jordan / epidemiology. Male. Middle Aged. Retrospective Studies. Sex Factors

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  • (PMID = 16939021.001).
  • [ISSN] 0198-7569
  • [Journal-full-title] The International journal of periodontics & restorative dentistry
  • [ISO-abbreviation] Int J Periodontics Restorative Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Cheng YS, Kessler H, Rees TD, Philofsky D, Pontikas A: Gingival swelling in a 13-year-old girl with multiple recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jan;103(1):85-91
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  • [Title] Gingival swelling in a 13-year-old girl with multiple recurrences.
  • We present a challenging case of gingival swelling that recurred several times in 3.5 years in a 13-year-old girl.
  • With the tissue specimens from subsequent multiple excisions and several immunohistochemical studies, the diagnoses evolved to benign cellular infiltrate of undetermined origin, epithelioid hemangioma, proliferating endothelial cell neoplasm of uncertain biologic potential, atypical vascular tumor, epithelioid hemangioendothelioma, and kaposiform hemangioendothelioma.
  • We discuss the list of differential diagnoses from various pathologists and propose our diagnosis of epithelioid hemangioendothelioma based on its clinical behavior, histologic features, and immunohistochemical findings.
  • [MeSH-major] Alveolar Process / surgery. Gingiva / pathology. Gingival Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Angiolymphoid Hyperplasia with Eosinophilia / pathology. Biomarkers / analysis. Biopsy. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Humans. Reoperation

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  • (PMID = 17178499.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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6. Ababneh K, Al-Khateeb T: Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report. J Contemp Dent Pract; 2009;10(6):E072-8
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  • [Title] Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report.
  • AIM: The aim of this report is to present the management of an aggressive, highly proliferative pregnancy tumor with clinical and radiographic characteristics highly suggestive of a malignant neoplasm.
  • BACKGROUND: Pregnancy tumor is a benign hyperplastic gingival lesion occurring during pregnancy that is indistinguishable from a pyogenic granuloma arising in nonpregnant females, or in males.
  • CASE DESCRIPTION: A 28-year-old woman at four months of gestation was referred for a massive gingival swelling (5.5 cm in greatest diameter) on the mandibular left side.
  • Advanced alveolar bone loss also was found beneath the lesion.
  • A malignant process was suspected, and an incisional biopsy revealed a pregnancy tumor.
  • SUMMARY: Pregnancy tumor represents an important differential diagnosis of oral masses and can behave in a very aggressive fashion, mimicking a malignant tumor.
  • CLINICAL SIGNIFICANCE: This lesion should always be included in the differential diagnosis of soft tissue masses in a pregnant woman even if the lesion is clinically very aggressive.
  • [MeSH-major] Alveolar Bone Loss / etiology. Gingival Neoplasms / pathology. Gingival Overgrowth / pathology. Granuloma, Pyogenic / pathology. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mandible. Pregnancy. Treatment Outcome

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  • (PMID = 20020084.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Brazão-Silva MT, Fernandes AV, Durighetto-Júnior AF, Cardoso SV, Loyola AM: Central odontogenic fibroma: a case report with long-term follow-up. Head Face Med; 2010;6:20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An osteolytic tumour of the mandible with prominent expansive growth on the alveolar ridge and displacement of the involved teeth is described in a 28-year-old man.
  • The lesion was diagnosed as a central odontogenic fibroma, an uncommon benign neoplasm derived from dental apparatus, and was removed by curettage.
  • The patient remains asymptomatic after thirteen years of follow-up, which supports the claimed indolent behavior of this poorly documented disease and the adequacy of a conservative surgical treatment.
  • [MeSH-major] Fibroma / surgery. Gingival Neoplasms / surgery. Odontogenic Tumors / surgery

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  • (PMID = 20707924.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2927520
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8. Abrahão AC, Camisasca DR, Bonelli BR, Cabral MG, Lourenço SQ, Torres SR, Pinto DS Jr: Recurrent bilateral gingival peripheral calcifying epithelial odontogenic tumor (Pindborg tumor): a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Sep;108(3):e66-71
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  • [Title] Recurrent bilateral gingival peripheral calcifying epithelial odontogenic tumor (Pindborg tumor): a case report.
  • Calcifying epithelial odontogenic tumor (CEOT) is an extremely rare, benign neoplasm, accounting for approximately 1% of all odontogenic tumors.
  • A 40-year-old female presented with bilateral soft, painful, erythematous, gingival swellings localized in premolar areas of the mandibular gingiva.
  • The presumptive diagnosis was bilateral pyogenic granuloma.
  • Morphologic features, and histochemical and immunohistochemical tests revealed bilateral peripheral calcifying odontogenic epithelial tumor.
  • Gingival masses must be carefully evaluated for clinical and histologic evidence of neoplasia.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Odontogenic Tumors / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Gingival Diseases / diagnosis. Granuloma, Pyogenic / diagnosis. Humans. Immunohistochemistry

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  • (PMID = 19716494.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Aytac-Yazicioglu D, Eren H, Görgün S: Peripheral odontogenic myxoma located on the maxillary gingiva: report of a case and review of the literature. Oral Maxillofac Surg; 2008 Sep;12(3):167-71
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  • [Title] Peripheral odontogenic myxoma located on the maxillary gingiva: report of a case and review of the literature.
  • BACKGROUND: Odontogenic myxoma is a rare, benign neoplasm and is often located in the maxillofacial region centrally most common in the mandible.
  • CASE REPORT: In this presentation, the patient with a peripheral odontogenic myxoma of the posterior maxillary gingiva was presented with histological findings following surgery, and the clinical differences and characteristics of the various types of myxomas were discussed by a review of the literature.
  • [MeSH-major] Gingival Neoplasms / pathology. Myxoma / pathology. Odontogenic Tumors / pathology

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  • (PMID = 18642035.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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10. LeCorn DW, Bhattacharyya I, Vertucci FJ: Peripheral ameloblastoma: a case report and review of the literature. J Endod; 2006 Feb;32(2):152-4
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  • Peripheral ameloblastoma is a rare, benign odontogenic tumor that histologically resembles an intraosseous ameloblastoma but develops in the soft tissues of the gingiva and mucosa and exhibits an innocuous clinical behavior.
  • We report a case of a recurrent peripheral ameloblastoma in a 61-year-old man that presented as a painless swelling on the maxillary anterior labial attached gingiva.
  • The peripheral ameloblastoma should be included in the differential diagnosis of a gingival lesion clinically resembling any of the myriads of entities seen on the gingiva including a pyogenic granuloma, peripheral giant cell granuloma, or parulis/gumboil.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Maxilla. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 16427467.001).
  • [ISSN] 0099-2399
  • [Journal-full-title] Journal of endodontics
  • [ISO-abbreviation] J Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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11. Chi AC, Barnes JD, Budnick S, Agresta SV, Neville B: Rhabdomyosarcoma of the maxillary gingiva. J Periodontol; 2007 Sep;78(9):1839-45
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  • [Title] Rhabdomyosarcoma of the maxillary gingiva.
  • BACKGROUND: Rhabdomyosarcoma is a malignant neoplasm of primitive mesenchyme exhibiting skeletal muscle differentiation.
  • METHODS: A 33-year-old woman presented with an erythematous gingival mass involving the anterior maxillary gingiva.
  • Many of the tumor cells exhibited abundant eosinophilic cytoplasm.
  • Immunohistochemical stains showed the tumor cells to be positive for desmin, myogenin, and myogenic differentiation 1 (MyoD1).
  • A diagnosis of embryonal rhabdomyosarcoma was made.
  • Pain is a variable presenting symptom, and early lesions may be mistaken for benign neoplastic, inflammatory, or infectious processes.
  • [MeSH-major] Gingival Neoplasms / pathology. Rhabdomyosarcoma / pathology

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  • (PMID = 17760557.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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12. Curien R, Moizan H, Gerard E: Gingival metastasis of a bronchogenic adenocarcinoma: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Dec;104(6):e25-8
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  • [Title] Gingival metastasis of a bronchogenic adenocarcinoma: report of a case.
  • We report the case of a 64-year-old patient suffering from a multiple metastatic bronchial adenocarcinoma, referred to our department for a gingival tumefaction.
  • The diagnostic assumptions considered were those of a pyogenic granuloma, of a primary gingival carcinoma, or of a metastasis of the bronchial tumor.
  • An excisional biopsy was carried out and the histopathologic examination confirmed the latter diagnosis.
  • If metastases of pulmonary cancers represent the majority of gingival metastases, those of bronchial adenocarcinoma are very rare.
  • The main clinical diagnostic difficulty is the distinction between benign lesion and malignant lesion, and between primary lesion and metastasis.
  • Even if gingival metastases are rare, their semiological value incites the histopathologic examination of any presumedly benign tumor of the gingiva.
  • [MeSH-major] Carcinoma, Bronchogenic / secondary. Gingival Neoplasms / secondary. Lung Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 17942337.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Gondivkar SM, Indurkar A, Degwekar S, Bhowate R: Primary oral malignant melanoma--a case report and review of the literature. Quintessence Int; 2009 Jan;40(1):41-6
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  • Malignant melanoma is a neoplasm of melanocytic origin that arises from a benign melanocytic lesion or de novo from melanocytes within otherwise normal mucosa or skin.
  • Because most mucosal melanotic lesions are painless in their early stages, the diagnosis is unfortunately often delayed until symptoms resulting from ulceration or growth are noted.
  • The case of a 40-year-old man with primary malignant melanoma of the maxillary gingiva is reported
  • [MeSH-major] Gingival Neoplasms / pathology. Melanoma / pathology
  • [MeSH-minor] Adult. Humans. Male. Maxilla / surgery. Neoplasm Staging

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  • (PMID = 19159022.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 19
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14. Wiel J, Luis W, Kempf HG: [The interesting case -- case no. 70]. Laryngorhinootologie; 2005 Mar;84(3):196-9
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  • We will report two cases of newborn girls, who could not be breast fed because of a benign tumour in their oral cavity.
  • Tumours were fleshy, firm, dark-brown with a broad-based attachment to the alveolar ridge.
  • The size of neoplasm was in one case 3 x 2 cm, in the other one 2 x 1.5 cm.
  • Histological findings showed large tumour cells with abundant granular eosinophilic cytoplasm and a prominent vascularity.
  • All these findings are characteristic of congenital granular cell tumour and its synonym congenital epulis.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Mouth Neoplasms / congenital
  • [MeSH-minor] Age Factors. Breast Feeding. Female. Gingiva / pathology. Humans. Immunohistochemistry. Infant, Newborn. Mouth / pathology. Sex Factors. Treatment Outcome

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  • (PMID = 15770569.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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15. Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE: Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature. J Periodontol; 2007 Aug;78(8):1639-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature.
  • BACKGROUND: Nerve sheath myxoma (NSM) is an extremely rare benign neoplasm in the oral cavity.
  • This paper describes the first case, to our knowledge, of NSM in the gingival mucosa of an 84-year-old female patient.
  • METHODS: Intraoral examination revealed a painless and well-defined nodule in the lingual gingival mucosa of the right mandibular lateral incisor, which measured approximately 1.0 cm in diameter.
  • A trauma-induced gingival hyperplasia was the main diagnostic hypothesis.
  • According to the histopathologic and immunohistochemical features, the diagnosis of NSM was established.
  • CONCLUSION: Although NSM is an extremely rare oral tumor, it should be considered in the clinical differential diagnosis of gingival nodules.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myxoma / diagnosis. Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Gingival Hyperplasia / diagnosis. Humans. Incisor / pathology. Mandible / pathology. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 17668985.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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16. Fleury RN, Damante JH, Soares CT, Sant'Ana E, Mello EJ Jr, Moreira CR: Malignant fibrous histiocytoma (undifferentiated high-grade pleomorphic sarcoma) occurring in tuberous sclerosis: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Apr;103(4):e54-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis is an autosomal dominant genetic disorder that is characterized by the early development of hamartomas, malformations, and congenital tumors of the nervous system, skin, kidneys, lungs, and heart.
  • Variable clinical expressivity has been reported and more than one gene can be responsible for the disorder.
  • Benign neoplasias accompanying the syndrome are common but malignant neoplasias are rare, being generally mesenchymal and possibly affecting the jaws.
  • We report here a clinical case of a malignant fibrous histiocytoma (undifferentiated high-grade pleomorphic sarcoma) of the mandible in a patient with tuberous sclerosis.
  • [MeSH-major] Gingival Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Tuberous Sclerosis / complications
  • [MeSH-minor] Adolescent. Biopsy. Diagnosis, Differential. Humans. Male


17. Azevedo Rde S, Pires FR, Della Coletta R, de Almeida OP, Kowalski LP, Lopes MA: Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jun;105(6):e35-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis.
  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • Differential diagnosis included benign and malignant mesenchymal neoplasms, salivary gland tumors, and reactive processes.
  • Microscopic analysis of both lesions revealed a spindle cell tumor with immunoreactivity for vimentin, muscle-specific actin, and specific smooth muscle isoform alpha-actin, rendering the diagnoses of myofibroma.
  • Myofibroma presents a wide range of differential diagnosis, including benign and malignant neoplasms.
  • Therefore, accurate diagnosis may avoid an unnecessary aggressive therapy.
  • [MeSH-major] Gingival Neoplasms / pathology. Lip Neoplasms / pathology. Myofibroma / pathology
  • [MeSH-minor] Actins / analysis. Child. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Vimentin / analysis

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  • (PMID = 18417385.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Vimentin
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18. Levi PA Jr, Kim DM, Harsfield SL, Jacobson ER: Squamous cell carcinoma presenting as an endodontic-periodontic lesion. J Periodontol; 2005 Oct;76(10):1798-804
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Regardless of advances in diagnosis and treatment during the past 40 years, the overall 5-year survival rates for oral and oropharyngeal squamous cancers have only slightly improved and remain around 50%.
  • Thus, the early diagnosis and treatment of carcinoma by health care providers are essential in achieving a good prognosis.
  • We report a case of invasive squamous cell carcinoma that presented as a benign endodontic-periodontic lesion with a 7-mm periodontal pocket on tooth #15 in a 40-year-old, non-smoking woman.
  • The patient remained free of tumor for 5 years after the initial presentation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Maxillary Neoplasms / pathology. Periodontal Cyst / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Maxillary Sinus Neoplasms / pathology. Neoplasm Invasiveness / pathology

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  • (PMID = 16253104.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Mikou A, Al Bouzidi A, Kabbaj R, Chahdi H, Kamous W, Zoubeir Y, Rharrassi I, Rimani M, Labraimi A, El Khatib M, Rzin A, Nassih M: [Desmoplastic ameloblastoma in a 7 year old child]. Rev Laryngol Otol Rhinol (Bord); 2008;129(4-5):341-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Améoblastome desmoplastique chez un enfant de 7 ans.
  • Desmoplastic ameloblastoma is a benign, locally aggressive neoplasm of proliferating odontogenic epithelial origin.
  • We report the case of a 7 year old child, having presented since the 5 years age, a gingival tumefaction on the left higher incisivo-canin group which increased volume gradually.
  • The stomatologic examination showed a gingival tumefaction covered with a healthy mucous membrane, ovoid form and measuring 3 cm on its horizontal axis.
  • A curetting of the lesion was carried out and the anatomopathologic examination retained the diagnosis of desmoplastic ameloblastoma.
  • A radical surgical treatment is suggested for this tumour to avoid recurrency.

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  • (PMID = 19408524.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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20. Shigeishi H, Yamaguchi S, Mizuta K, Nakakuki K, Fujimoto S, Amagasa T, Kamata N: Amphiregulin induces proliferative activities in osseous dysplasia. J Dent Res; 2009 Jun;88(6):563-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Human osseous dysplasia (OD) is a benign fibro-osseous neoplasm of periodontal ligament origin in which normal bone is replaced with fibrous connective tissue containing abnormal bone or cementum.
  • We identified amphiregulin to be highly expressed in OD-1 compared with osteoblasts and gingival fibroblasts.
  • [MeSH-minor] Adolescent. Amphiregulin. Cell Line, Transformed. Cell Proliferation. Cells, Cultured. EGF Family of Proteins. Female. Fibroblasts / metabolism. Gingiva / cytology. Gingiva / metabolism. Humans. Oligonucleotide Array Sequence Analysis. Osteoblasts / metabolism. Periodontal Ligament / metabolism. Recombinant Proteins / pharmacology

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  • (PMID = 19587163.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AREG protein, human; 0 / Amphiregulin; 0 / EGF Family of Proteins; 0 / Glycoproteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Recombinant Proteins
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21. Dias PF, Pedro Rde L, Janine ME, Maia LC: Congenital epulis: an unusual case of spontaneous regression. Gen Dent; 2008 Jul-Aug;56(5):e25-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Congenital epulis is a rare benign neoplasm of the soft tissues.
  • Typically, this condition manifests as a firm, smooth, pink mass that appears exclusively on the alveolar ridges in newborn infants.
  • This article reports an unusual case of a girl whose dentist diagnosed congenital epulis when she was 16 months old; the epulis disappeared completely three months later.
  • [MeSH-major] Gingival Neoplasms / congenital. Neoplasm Regression, Spontaneous / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant

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  • (PMID = 21444268.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Kim K, Velez I, Kaltman SI, Lopez E, Stern D: Odontogenic carcinoma differentiation into rhabdomyosarcoma: report of a rare case. Quintessence Int; 2009 Nov-Dec;40(10):837-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Odontogenic carcinoma differentiation into rhabdomyosarcoma: report of a rare case.
  • The histology and clinical features of this aggressive odontogenic neoplasm are described.
  • Within the English-language literature, only 2 cases are reported of an odontogenic tumor with muscle differentiation: a benign odontogenic tumor (ameloblastoma) with differentiation into a rhabdomyosarcoma and an odontogenic sarcoma with smooth-muscle differentiation.
  • [MeSH-major] Gingival Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Odontogenic Tumors / pathology. Rhabdomyosarcoma / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Gingival Diseases / diagnosis. Granuloma, Giant Cell / diagnosis. Granuloma, Pyogenic / diagnosis. Humans. Male. Maxillary Neoplasms / pathology

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  • (PMID = 19898715.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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23. Gallego L, Junquera L, Baladrón J, Villarreal P: Oral squamous cell carcinoma associated with symphyseal dental implants: an unusual case report. J Am Dent Assoc; 2008 Aug;139(8):1061-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This case report describes a patient with history of oral lichen planus (OLP) and previous SCCa of the gingiva who developed SCCa adjacent to symphyseal implants.
  • CLINICAL IMPLICATIONS: This case report demonstrates that recurrent primary malignancy can masquerade as benign peri-implant complications.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Dental Implants / adverse effects. Gingival Neoplasms / etiology. Mandibular Neoplasms / etiology. Neoplasm Recurrence, Local / etiology

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  • (PMID = 18682620.001).
  • [ISSN] 0002-8177
  • [Journal-full-title] Journal of the American Dental Association (1939)
  • [ISO-abbreviation] J Am Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dental Implants
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24. Koyuncu BO, Zeytinoğlu M, Unal T, Zeytinoğlu B: Myofibroma of the gingiva: report of a case. J Clin Pediatr Dent; 2010;34(3):253-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myofibroma of the gingiva: report of a case.
  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy.
  • This report describes a myofibroma of the gingiva in a 14 year old girl and is reported together with the conventional histologic, and immunohistochemical findings.
  • The tumor showed rapid increase in size and clinical features suggestive of malignancy.
  • However on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myofibroma / diagnosis
  • [MeSH-minor] Actins / analysis. Adolescent. Desmin / analysis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 20578664.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / Vimentin
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