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1. Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M: Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2010 May;32(3):215-21
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  • [Title] Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • We performed immunohistochemical assessment of p53 expression and TP53 mutational analysis of 15 malignant neoplasms arising from preexisting benign cylindroma, spiradenoma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • In one case only there were 2 p53 mutations, one being a c.673-1G>A splice-site mutation in the 3'-end of intron 6 (position--g.15289G>A, contig gb.AY838696.1) and the second being a c.743G>A (p.R248Q) mutation in exon 7 (position--15360G>A, contig gb.AY838696.1).
  • None of the 12 benign control group cases harbored a TP53 mutation, whereas all 12 demonstrated single nucleotide polymorphisms identical to those detected in the malignant tumor group.
  • In conclusion, we found a fairly high rate of p53 expression in malignant neoplasms arising from preexisting benign spiradenomas, cylindromas, and spiradenocylindromas.
  • Whereas immunostaining for p53 has been suggested as an adjunct tool to differentiate benign spiradenoma, cylindroma, and spiradenocylindroma from their malignant counterparts, its utility is limited by its heterogeneous pattern of expression, especially the sometimes lack of staining in clearly malignant areas and the occurrence of focal, weak positivity in the benign residua or in unequivocally benign neoplasms.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Neoplasms, Multiple Primary / genetics. Point Mutation. Sweat Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. DNA, Neoplasm / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Syndrome. Young Adult

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  • (PMID = 20075707.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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2. Nosrati N, Coleman NM, Hsu S: Axillary syringomas. Dermatol Online J; 2008;14(4):13
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  • Syringomas are common benign neoplasms encountered mostly around the eyes.
  • However, as described herein, these tumors can occur in atypical locations such as the axilla.
  • The differential diagnosis revolves around those entities more likely seen in this anatomical location (such as Fox-Fordyce, Hailey-Hailey and Darier diseases).
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis
  • [MeSH-minor] Adult. Axilla / pathology. Diagnosis, Differential. Female. Humans. Sex Factors. Skin / pathology

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  • (PMID = 18627735.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Xing BC, Sun Y, Bao Q, Qian HG, Hao CY, Huang XF, Wang Y, Gu J, Ji JF: [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm]. Zhonghua Yi Xue Za Zhi; 2006 Mar 14;86(10):690-2
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  • [Title] [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm].
  • OBJECTIVE: To investigate the feasibility and safety of spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins in treatment of benign neoplasms of distal pancreas.
  • METHODS: Four patients with solid-pseudopapillary neoplasm, 1 males and 3 females, aged 30 (17 - 37), underwent laparotomy.
  • The distal pancreas with tumor was cut.
  • CONCLUSION: Safe and feasible, spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins is one of the best choices for treatment of benign and borderline tumors of pancreas.
  • [MeSH-major] Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16681929.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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4. Hassounah M, Lach B, Allam A, Al-Khalaf H, Siddiqui Y, Pangue-Cruz N, Al-Omeir A, Al-Ahdal MN, Aboussekhra A: Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis. J Neurooncol; 2005 May;72(3):203-8
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  • [Title] Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis.
  • Here we have assessed the level of the survivin protein in some benign tumors of the nervous system: meningioma, schwannoma, low-grade ependymoma, pilocytic astrocytoma and pituitary adenoma.
  • Using immuno-blot analysis we present evidence that these low-grade tumors are positive for survivin expression.
  • In agreement, flow cytometrical analysis showed that both spontaneous and radiation-induced apoptosis levels are very low in these neoplasms.
  • Using host cell reactivation assay we have also shown that these tumor cells are proficient in the repair of gamma-ray-induced DNA damage.
  • These results suggest that survivin overexpression may be an early event in the stepwise tumoregenesis and hence could be responsible for the onset as well as the growth advantage during tumoregenic progression of malignant as well as benign neoplasms.
  • [MeSH-major] Apoptosis / physiology. Apoptosis / radiation effects. Microtubule-Associated Proteins / biosynthesis. Nervous System Neoplasms / metabolism. Nervous System Neoplasms / pathology
  • [MeSH-minor] Cell Line, Tumor. DNA Damage / radiation effects. Electrophoresis, Polyacrylamide Gel. Flow Cytometry. Gamma Rays. Genes, p53 / genetics. Genes, p53 / radiation effects. Humans. Immunoblotting. Inhibitor of Apoptosis Proteins. Neoplasm Proteins / metabolism. Oncogene Protein p21(ras) / biosynthesis. Oncogene Protein p21(ras) / radiation effects. Tumor Cells, Cultured. Ultraviolet Rays

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  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 3.6.5.2 / Oncogene Protein p21(ras)
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5. Ritter MR, Reinisch J, Friedlander SF, Friedlander M: Myeloid cells in infantile hemangioma. Am J Pathol; 2006 Feb;168(2):621-8
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  • Little is known about the pathogenesis of infantile hemangiomas despite the fact that they are relatively common tumors.
  • These benign neoplasms occur in as many as 1 in 10 births, and although rarely life threatening, hemangiomas can pose serious concerns to the cosmetic and psychosocial development of the afflicted child.

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  • (PMID = 16436675.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / F32 EY013916; United States / NEI NIH HHS / EY / R01 EY011254; United States / NEI NIH HHS / EY / F32 EY13916; United States / NEI NIH HHS / EY / R01 EY11254
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD14; 0 / Antigens, CD15; 0 / CD83 antigen; 0 / Immunoglobulins; 0 / Membrane Glycoproteins; 0 / Receptors, IgG
  • [Other-IDs] NLM/ PMC1606494
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6. Bellolio J E, Guzmán G P, Orellana C J, Roa S JC, Villaseca H M, Araya O JC, Tapia E O, Ineda N V: [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms]. Rev Med Chil; 2009 Sep;137(9):1173-8
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  • [Title] [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms].
  • [Transliterated title] Validez diagnóstica de la biopsia intraoperatoria en cirugía de lesiones mamarias palpables.
  • BACKGROUND: During the surgical treatment of breast neoplasms (benign or malignant), frozen section biopsy is frequently requested to assess the kind of lesion and determine the surgical margins.
  • MATERIAL AND METHODS: AH the pathological reports of frozen section biopsies and definitive biopsies of 337 women aged 26 to 88 years, operated for suspected breast neoplasms between 2002 and 2006, were reviewed.
  • The diagnosis of phyllodes tumor was missed by frozen section biopsy in three cases.
  • [MeSH-major] Biopsy / methods. Breast Neoplasms / pathology. Frozen Sections / standards. Intraoperative Care / methods

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  • (PMID = 20011957.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
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7. Schmitz-Feuerhake I, Pflugbeil S, Pflugbeil C: [Radiation risks from diagnostic radiology: meningiomas and other late effects after exposure of the skull]. Gesundheitswesen; 2010 Apr;72(4):246-54
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  • [Title] [Radiation risks from diagnostic radiology: meningiomas and other late effects after exposure of the skull].
  • [Transliterated title] Röntgenrisiko: Abschätzung der strahleninduzierten Meningeome und anderer Spätschäden bei Exposition des Schädels.
  • A complete assessment of late effects of X-ray diagnostics should take into account that radiation sensitivity varies considerably for the different ages at exposure and, furthermore, that not only malignant diseases but also benign neoplasms are induced which also may lead to severe detriment of the patient.
  • Dose-effect relationships for tumours of the brain, skin, thyroid, and other sites of the head region, leukaemia, and cataracts are taken from the literature.
  • 1,000 annual paediatric CT investigations of the skull will lead to about 3 excess neoplasms in the head region, i.e., the probability of an induced late effect must be suspected in the range of some thousandths.
  • The radiation-induced occurrence of meningiomas and other brain tumours most probably contributes to the continuously increasing incidence of these diseases which is observed in several industrial nations, as well as the exposure of the bone marrow by CT to the increase of childhood leukaemia.
  • [MeSH-major] Brain Neoplasms / etiology. Brain Neoplasms / radiography. Meningeal Neoplasms / etiology. Meningioma / etiology. Neoplasms, Radiation-Induced / etiology. Skull / radiation effects. Tomography, X-Ray Computed / adverse effects

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 19551621.001).
  • [ISSN] 1439-4421
  • [Journal-full-title] Gesundheitswesen (Bundesverband der Ärzte des Öffentlichen Gesundheitsdienstes (Germany))
  • [ISO-abbreviation] Gesundheitswesen
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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8. Joyner DE, Wade ML, Szabo A, Bastar J, Coffin CM, Albritton KH, Bernard PS, Randall RL: Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo. J Cancer Res Clin Oncol; 2005 Mar;131(3):137-46
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  • [Title] Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo.
  • BACKGROUND: Mesenchymal neoplasia comprises a heterogeneous group of tumors with over 200 benign neoplasms and 100 sarcomas.
  • Currently, tumors are classified using histologic and immunocytologic characteristics, with diagnostic error rates reported as high as 40% of cases.
  • As a feasibility study, our goal was to generate a preliminary discriminatory gene list for selected mesenchymal tumors, including sarcomas.
  • This technique may enable an eventual molecular classification schema based on expression profiles that can complement current clinical and pathologic diagnostic procedures in mesenchymal tumors.
  • METHODS: cDNA microarray analyses were preformed on connective tissue tumors obtained at time of surgical resection or biopsy.
  • Messenger RNA (mRNA) from four general tumor classes was competitively hybridized against a human dermal fibroblast cell line comparator and the resulting gene expression profiles processed by ANOVA and linear discriminate analysis.
  • RESULTS: The tissue classification involved 18 patients with malignant peripheral nerve sheath tumors, giant cell containing tumors, benign spindle cell lesions, or Ewing's family of tumors.
  • CONCLUSIONS: Linear discriminate analysis of cDNA gene expression profiles partitioned mesenchymal tumor classes, even when constrained by limited sample sizes.
  • [MeSH-major] DNA Fingerprinting. DNA, Neoplasm / analysis. Mesenchymoma / diagnosis. Mesenchymoma / genetics. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / genetics. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Analysis of Variance. Carcinoma / diagnosis. Carcinoma / genetics. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / genetics. Cell Line. Feasibility Studies. Fibroblasts. Gene Expression Regulation, Neoplastic. Humans. Linear Models. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / genetics. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / genetics. Skin / cytology

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  • (PMID = 15614524.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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9. Cavaliere R, Lopes MB, Schiff D: Low-grade gliomas: an update on pathology and therapy. Lancet Neurol; 2005 Nov;4(11):760-70
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  • Low-grade gliomas (LGG) are not benign neoplasms.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / therapy. Glioma / pathology. Glioma / therapy

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  • (PMID = 16239183.001).
  • [ISSN] 1474-4422
  • [Journal-full-title] The Lancet. Neurology
  • [ISO-abbreviation] Lancet Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 119
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10. Ducic Y, Oxford L, Pontius AT: Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg; 2006 Mar;134(3):466-70
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  • OBJECTIVES: To present our early experience with the transoral approach to the superomedial parapharyngeal space (PPS) and describe our technique for removal of these neoplasms.
  • METHODS: Eight patients with various neoplasms of the superomedial PPS were retrospectively reviewed for type of neoplasm, size, success with the transoral approach, need for conversion to another approach, length of hospitalization, and complications.
  • RESULTS: The transoral approach described herein safely allowed for en bloc resection of benign neoplasms with intraoperative control and exposure of the internal carotid artery.
  • Mean tumor size was 3.3 cm (range, 1.5 to 7 cm).
  • This technique is indicated for neoplasms with benign appearance on preoperative imaging or fine needle aspiration.
  • [MeSH-major] Mouth / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carotid Artery, Internal / pathology. Child. Female. Follow-Up Studies. Humans. Intraoperative Care. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications. Retrospective Studies. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 16500446.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Levy MJ, Gleeson FC, Campion MB, Caudill JL, Clain JE, Halling K, Rajan E, Topazian MD, Wang KK, Wiersema MJ, Clayton A: Prospective cytological assessment of gastrointestinal luminal fluid acquired during EUS: a potential source of false-positive FNA and needle tract seeding. Am J Gastroenterol; 2010 Jun;105(6):1311-8
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  • [Title] Prospective cytological assessment of gastrointestinal luminal fluid acquired during EUS: a potential source of false-positive FNA and needle tract seeding.
  • OBJECTIVES: Endoscopic ultrasound (EUS) fine needle aspiration (FNA) can result in false-positive cytology and can also cause needle tract seeding.
  • Our goal was to evaluate a potential cause, namely, the presence of malignant cells within gastrointestinal (GI) luminal fluid, either as a result of tumor sloughing from luminal cancers or secondary to FNA of extraluminal sites.
  • METHODS: During EUS, luminal fluid that is usually aspirated through the echoendoscope suction channel and discarded was instead submitted for cytological analysis among patients with cancer and benign disease.
  • The final diagnosis was based on strict clinicopathological criteria and >or=2-year follow-up.
  • This study was conducted in a tertiary referral center.
  • RESULTS: We assessed the prevalence of luminal fluid-positive cytology among patients with luminal (e.g., esophageal), extraluminal (e.g., pancreatic), and benign disease.
  • CONCLUSIONS: Malignant cells are commonly present in the GI luminal fluid of patients with luminal cancers and can also be found in patients with pancreatic cancer after EUS FNA.
  • Further study is needed to determine the impact of these findings on cytological interpretation, staging, risk of needle tract seeding, and patient care and outcomes.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Gastrointestinal Tract / pathology. Neoplasm Seeding. Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Endosonography. Female. Gastrointestinal Contents. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 20197762.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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12. Sugár I, Forgács B, István G, Bognár G, Sápy Z, Ondrejka P: Gastrointestinal stromal tumors (GIST). Hepatogastroenterology; 2005 Mar-Apr;52(62):409-13
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  • [Title] Gastrointestinal stromal tumors (GIST).
  • BACKGROUND/AIMS: Gastrointestinal stromal tumors (GIST) are the most frequent non-epithelial tumors of the alimentary tract.
  • GIST's occur throughout the gastrointestinal tract but are generally located in the stomach and the intestine.
  • The tumor size, mitotic rate, cellularity and nuclear pleomorphism are the most important parameters characterizing the biological behavior of tumors.
  • The diagnostic procedures are similar to those of other gastrointestinal neoplasms but only a half of the patients will have correct preoperative histological diagnosis.
  • RESULTS: All but one proved to be benign.
  • CONCLUSIONS: GIST is a rare neoplasm of the GI tract.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Incidental Findings. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 15816446.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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13. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Non-specificity of clinical and radiological features of these maxillary lesions makes their diagnosis difficult.
  • The awareness of the spectrum of pathology related to maxillary swelling is essential for correct diagnosis and treatment.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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14. Usunova I, Vladimirov V: [Benign neoplasms of female urethra]. Akush Ginekol (Sofiia); 2009;48(1):31-3
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  • [Title] [Benign neoplasms of female urethra].
  • In clinical practice neoplasms of female urethra are found usually in adult women.
  • Histological sample analysis has provided diagnosis of urethral polyp, caruncle and mucosal prolaps.
  • Collaboration between urologists and gynecologists is essential for early diagnosis, prophylaxis and successful treatment of above mentioned diseases.
  • [MeSH-major] Urethral Neoplasms / diagnosis. Urethral Neoplasms / surgery

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  • (PMID = 19496462.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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15. Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC: Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer; 2008 Mar;15(1):243-56
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  • [Title] Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
  • Current classifications of human gastroenteropancreatic neuroendocrine tumors (NETs) are inconsistent and based upon histopathologic but not molecular features.
  • We sought to compare a molecular classification with the World Health Organization (WHO) histologic classification, identify genes that may be important for tumor progression, and determine whether gastrointestinal NETs (GI-NETs) differ in their molecular profile from pancreatic NETs (PNETs).
  • DNA microarray analysis was performed to identify differentially expressed genes in PNETs and GI-NETs.
  • Hierarchical clustering of 19 PNETs revealed a 'benign' and 'malignant' cluster that corresponded well with the WHO categories of well-differentiated endocrine tumor (WDET) and well-differentiated endocrine carcinoma (WDEC) respectively.
  • Malignant ileal GI-NETs exhibited a distinctive gene expression profile, and extracellular matrix protein 1 (ECM), vesicular monoamine member 1 (VMAT1), galectin 4 (LGALS4), and RET Proto-oncogene (RET) were highly up-regulated genes.
  • Gene expression profiles reflect the current WHO classification and can distinguish benign from malignant PNETs and also PNETs from GI-NETs.
  • This suggests that molecular profiling may enhance tumor classification schemes.

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  • (PMID = 18310291.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK040561; None / None / / P30 DK040561-12; United States / NIDDK NIH HHS / DK / P30 DK040561-12
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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16. Chekrine T, Tawfiq N, Bourhaleb Z, Benchakroun N, Jouhadi H, Sahraoui S, Benider A: [Giant-cell bone tumors of the spine: report of two cases and literature review]. Cancer Radiother; 2009 Sep;13(5):451-4
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  • [Title] [Giant-cell bone tumors of the spine: report of two cases and literature review].
  • [Transliterated title] Deux cas de tumeurs osseuses à cellules géantes du rachis et revue de la littérature.
  • Giant cell tumours (GCT) are relatively rare neoplasms, most often benign.
  • We report two observations of GCT, the spine in a 51-year-old woman and a 14-year-old boy.
  • Computed tomography and magnetic resonance imaging showed osteolysis of the body and vertebral arch of L5 for the first and a process affecting the vertebral body and medullary canal of T6-T7 with spinal cord compression for the second case.
  • The diagnosis was confirmed by histological examination in two cases.
  • [MeSH-major] Giant Cell Tumor of Bone / radiotherapy. Spinal Neoplasms / radiotherapy

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  • (PMID = 19615930.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 15
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17. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • [Title] Diagnosis and management of neoplastic lesions of the submandibular triangle.
  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • Definitive diagnosis was by excision and pathological examination.
  • Pleomorphic adenoma (n=37) were the most common benign neoplasms.
  • The most frequent primary lesions were malignant non-Hodgkin lymphoma (n=22), adenoid cystic carcinoma (n=9) and mucoepidermoid carcinoma (n=9).
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • Submandibular triangle neoplasms are rare and pose many diagnostic and therapeutic challenges.
  • There is a relatively high incidence of malignant neoplasms in this region (54%).
  • Benign tumours manifest a mild course of disease and have an excellent prognosis following adequate excision.
  • Malignant tumours have a poor symptomatology that can result in late (often post-operative) diagnosis.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.
  • [MeSH-major] Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Capovilla M, Couturier J, Molinié V, Bruneval P, Vieillefond A: [Juxtaglomerular cell tumors: report of two cases with genomic analysis]. Ann Pathol; 2008 Oct;28(5):474-6
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  • [Title] [Juxtaglomerular cell tumors: report of two cases with genomic analysis].
  • [Transliterated title] Tumeur à rénine du rein : à propos de deux cas, avec analyse génomique.
  • Juxtaglomerular-cell tumor (JGCT), first described in 1967, is a rare tumor of the kidney that derives from specialized smooth-muscle cells of the wall of the glomerular afferent arteriole.
  • JGCTs are considered benign, but the clinical follow-up has been short in most reported cases.
  • Only one metastatic case has been reported to date, raising the question of tumors of uncertain malignant potential rather than clearly benign neoplasms.
  • Similarly to the two previously reported cases, these two tumors showed losses on chromosomes 9 and 11, suggesting recurrent chromosomal imbalances.
  • Thus, JGCT might be better considered as a tumor of uncertain malignant potential consequently requiring a prolonged follow-up.
  • [MeSH-major] Juxtaglomerular Apparatus / pathology. Kidney Cortex / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19068398.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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19. Bisdas S, Baghi M, Wagenblast J, Knecht R, Thng CH, Koh TS, Vogl TJ: Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: feasibility of the method and initial results. Eur J Radiol; 2007 Nov;64(2):258-65
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  • [Title] Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: feasibility of the method and initial results.
  • AIM: We evaluated the feasibility of perfusion CT (CTP) of the parotid gland and attempted to differentiate benign from malignant tumors.
  • MATERIALS AND METHODS: CTP was performed in 17 patients with benign tumors and 10 patients with malignant parotid tumors.
  • Regions of interest were placed through the tumor site and the contralateral healthy parotid tissue.
  • Ratios of the perfusion values between the tumors and the contralateral healthy structures were also calculated.
  • RESULTS: Perfusion maps of all tumors were successfully obtained.
  • High Pearson correlation coefficients comparing the two readers' visually measured abnormalities were observed (r=0.79-0.86, P=0.001) for all perfusion maps, The MTT and PS values between malignant and benign tumors were not significantly different.
  • The BF and BV values were statistically significant different between the benign and malignant tumors (0.00<P<0.02).
  • Only the BV ratio criterion between malignant and benign neoplasms was statistically significant (P<0.004).
  • CONCLUSIONS: CTP of the parotid gland is feasible and may differentiate malignant from non-malignant lesions by means of absolute BF, BV and BV ratio values.
  • [MeSH-major] Image Processing, Computer-Assisted / methods. Parotid Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma / radiography. Adenolymphoma / radiography. Adenoma, Pleomorphic / radiography. Aged. Blood Volume / physiology. Capillary Permeability / physiology. Carcinoma, Adenoid Cystic / radiography. Contrast Media. Diagnosis, Differential. Feasibility Studies. Female. Humans. Iopamidol / analogs & derivatives. Male. Middle Aged. Parotid Gland / blood supply. Parotid Gland / radiography. Radiographic Image Enhancement / methods. Regional Blood Flow / physiology. Time Factors

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  • (PMID = 17399933.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 17E17JBP8L / iomeprol; JR13W81H44 / Iopamidol
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20. Yates CW, Weinberg M, Packer MJ, Jacob A: Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma. Ann Otol Rhinol Laryngol; 2010 Jun;119(6):402-5
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  • [Title] Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma.
  • Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve.
  • We report the case of a 69-year-old man with a large vestibular schwannoma who required anticoagulation for several medical comorbidities.
  • Attempts were made to stabilize the patient, including posterior fossa craniectomy and evacuation of hematoma; however, the intracranial hemorrhage ultimately resulted in a fatal outcome.
  • During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma.

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  • (PMID = 20583739.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin
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21. Spalding DR, Isla AM, Thompson JN, Williamson RC: Pancreas-sparing distal duodenectomy for infrapapillary neoplasms. Ann R Coll Surg Engl; 2007 Mar;89(2):130-5
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  • [Title] Pancreas-sparing distal duodenectomy for infrapapillary neoplasms.
  • INTRODUCTION: For neoplasms that arise in the third and fourth parts of the duodenum (D(3), D(4)), a duodenectomy that preserves the pancreas can provide adequate tumour clearance while avoiding the additional dissection and risk of the common alternative, pancreatoduodenectomy.
  • PATIENTS AND METHODS: Pancreas-sparing distal duodenectomy (PSDD) was performed in 14 patients with infrapapillary duodenal neoplasms between 1991-2002, and the clinical outcome is reviewed.
  • There were 11 malignant neoplasms (adenocarcinoma 5, stromal tumour 4, recurrent seminoma 1, plasmacytoma 1), 2 benign neoplasms (villous adenoma, lipoma) and 1 patient with steroid-induced ulceration.
  • Median operation time was 240 min and median blood loss 1197 ml, being greater for malignant than benign lesions (1500 ml versus 700 ml).
  • At a median follow-up of 47 months, three patients had died of recurrent disease while the other 10 were alive and well with no upper gastrointestinal symptoms.
  • CONCLUSIONS: Provided there is a minimum 1-cm clearance at the papilla, PSDD is a useful alternative to formal pancreatoduodenectomy in patients with unusual neoplasms arising from the third and fourth parts of the duodenum.
  • Although a major undertaking in its own right, it avoids the extra time of a pancreatic resection and the extra risk of a pancreatic anastomosis.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Duodenal Neoplasms / surgery. Pancreas / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17346405.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1964558
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22. Brønden LB, Eriksen T, Kristensen AT: Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2009;51:54
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  • [Title] Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • Neoplasms originating in the head and neck region are a heterogeneous group.
  • Also the proportions of benign and malignant neoplasms of different locations in dogs were compared using Fisher's exact test.
  • RESULTS: A total of 1768 cases of neoplasias (679 malignant, 826 benign, 263 unknown) were submitted.
  • Of all neoplasias HNC accounted for 7.2% (n = 128).
  • Of these, 64 (50%) were malignant and 44 (34%) benign.
  • The most common types of malignant neoplasia were SCC (18; 28% of malignant), OMM (13; 20% of malignant), soft tissue sarcoma (11; 17% of malignant) and adenocarcinoma (5; 11% of malignant).
  • The most common types of benign neoplasms were adenoma (7; 16% of benign), polyps (6; 14% of benign) and fibroma (5; 11% of benign).
  • CONCLUSIONS: In the current study, the proportion of neoplasia in the head and neck region in dogs in Denmark was similar to other canine studies and significantly more common than in humans with a large proportion of malignancies.
  • [MeSH-major] Dog Diseases / epidemiology. Head and Neck Neoplasms / veterinary. Melanoma / veterinary. Mouth Neoplasms / veterinary. Registries

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  • (PMID = 20021647.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803174
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23. Arai E, Nishida Y, Tsukushi S, Sugiura H, Ishiguro N: Intramuscular granular cell tumor in the lower extremities. Clin Orthop Relat Res; 2010 May;468(5):1384-9
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  • [Title] Intramuscular granular cell tumor in the lower extremities.
  • Granular cell tumors are uncommon but typically histologically benign neoplasms that occasionally behave as malignant tumors.
  • Differentiation of benign granular cell tumors from malignant counterparts with radiographic and/or histologic analysis is crucial for physicians.
  • We retrospectively studied five cases of intramuscular granular cell tumors arising in the lower extremities.
  • All tumors had been histologically diagnosed as benign and were resected with a wide surgical margin.
  • Intramuscular granular cell tumors can be diagnosed based on their characteristic MRI features, such as peripheral high intensity on T2-weighed images, and histologic evaluation.
  • The histologic criteria described by Fanburg-Smith et al. can differentiate malignant granular cell tumors from benign tumors.
  • A wide resection seems suitable for most granular cell tumors in the extremities.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Leg
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Retrospective Studies. Time Factors

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  • (PMID = 19760336.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853648
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24. Russo A, Zaottini A: [Diagnosis of synovial sarcoma of the knee accidentally revealed by trauma. Role of ultrasound. Differential diagnosis by scar-hematoma]. Ann Ital Chir; 2009 Mar-Apr;80(2):151-7
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  • [Title] [Diagnosis of synovial sarcoma of the knee accidentally revealed by trauma. Role of ultrasound. Differential diagnosis by scar-hematoma].
  • [Transliterated title] Diagnosi di sarcoma sinoviale del ginocchio fortuitamente favorita da evento traumatico. Il contributo dell'ecografia in urgenza al sospetto clinico e la diagnosi differenziale con l'ematoma in fase di cicatrizzazione.
  • Generally arising in the contest of joint or from immediately surrounding anatomical sites, first of all affecting inferior limbs (2/3), a sarcoma of the knee, elective anatomical site, is described, accidentally diagnosed after traumatic event.
  • Exhibiting a very poor 5 year survey, (55%), related to dimension, distal or proximal arising, necrosis rate and grading, it's the most fequently soft tissue malignancy misdiagnosed with benign neoplasms, such as Baker cyst or villonodular pigmented synovitis, considering its deceiving macroscopic and chronological features; the differential diagnosis seems to be very hard, relying on histhological biopsy.
  • [MeSH-major] Cicatrix, Hypertrophic / ultrasonography. Hematoma / ultrasonography. Knee Injuries / ultrasonography. Knee Joint / ultrasonography. Sarcoma, Synovial / ultrasonography. Soft Tissue Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Incidental Findings. Male. Middle Aged. Prognosis. Treatment Outcome

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  • (PMID = 19681299.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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25. Naama O, Gazzaz M, Akhaddar A, Belhachmi A, Asri A, Elmostarchid B, Elbouzidi A, Kadiri B, Boucetta M: Cavernous hemangioma of the skull: 3 case reports. Surg Neurol; 2008 Dec;70(6):654-9
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  • BACKGROUND: Intraosseous cavernous hemangiomas of the bone are uncommon tumors, accounting for 0.7% to 1% of all bone neoplasms.
  • Calvarial cavernous hemangioma is rare, comprising about 0.2% of all benign neoplasms of the skull.
  • CONCLUSION: Skull cavernous hemangiomas are rare benign tumors.
  • The preferred treatment is complete tumor removal with normal bony margins.
  • Consequently, the diagnosis is most often made during surgical resection.
  • [MeSH-major] Hemangioma, Cavernous / pathology. Skull Neoplasms / pathology

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  • (PMID = 18207223.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Santos RR, Damasceno RW, de Pontes FS, Cursino SR, Nishiwaki-Dantas MC, Vital Filho J, Dantas PE: Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings. Arq Bras Oftalmol; 2010 Jan-Feb;73(1):33-9
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  • [Title] Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings.
  • PURPOSE: To describe and analyze the features of a cases series of patients with primary epithelial neoplasms of the lacrimal gland, its surgical treatment, and histopathological findings.
  • METHODS: Retrospective evaluation of files from patients with primary epithelial neoplasms of the lacrimal gland in the period from 1997 to 2007.
  • All patients with primary epithelial tumors of the lacrimal gland were included in this study.
  • The slides with histological sections of the tumors were reviewed by the same pathologist.
  • RESULTS: During the study period, there were 12 patients, 5 (41.7%) with benign tumors, all pleomorphic adenomas (benign mixed tumor) and 7 (58.3%) with malignant neoplasms, thus distributed: four cases of adenoid cystic carcinoma, two of mucoepidermoid carcinoma and one carcinoma expleomorphic adenoma.
  • Globally, patients mean age was 54.1 years-old (ranging from 14 to 70 years-old), with mean age of 52.4 years-old (ranging from 14 to 65 years-old) for benign neoplasms, and 55.3 years-old for malignant neoplasms (ranging from 26 to 70 years-old).
  • CONCLUSIONS: The most frequent primary epithelial neoplasms of the lacrimal gland were pleomorphic adenoma and adenoid cystic carcinoma during the study period.
  • Malignant tumors were more frequent than benign tumors.
  • The histopathological diagnosis and the disease initial stage can play a significant role in patient's survival.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Young Adult

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  • (PMID = 20464111.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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27. Tian W, Li X, Li D, Liu X, Lin S, Liang Y: [Imageology features and transoral approach of benign parapharyngeal space tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Nov;24(21):983-6
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  • [Title] [Imageology features and transoral approach of benign parapharyngeal space tumors].
  • OBJECTIVE: To analyze the imageology features of benign parapharyngeal space (PPS) tumors, and also to summarize our experience in removing PPS benign tumors through transoral approach.
  • METHOD: A retrospective review was conducted to 48 patients with benign tumors in PPS during a 10-year period.
  • RESULT: CT scan and MRI often provided complementary information to help the surgeons delineate the size, precise location and likely cause of these tumors.
  • The transoral approach described herein safely allowed for en bloc resection of most benign neoplasms.
  • CONCLUSION: CT or MRI scan can distinguish prestyloid from poststyloid lesions, and to assess the extension of the tumor as well as its relationship with adjacent structures.
  • The transoral approach safely provides access to some benign PPS tumors with a low rate of complications and recurrence as well as traditional transcervical approaches.
  • [MeSH-major] Neoplasms / diagnosis. Neoplasms / surgery. Pharyngeal Neoplasms / diagnosis. Pharyngeal Neoplasms / surgery

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  • (PMID = 21261019.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Meher R, Varshney S: Leiomyoma of the nose. Singapore Med J; 2007 Oct;48(10):e275-6
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  • Leiomyomas are benign neoplasms that are thought to originate from the vascular smooth muscle.
  • They have a propensity to arise from the gastrointestinal tract, female genital tract (uterus) and subcutaneous tissue.
  • The nasal cavity is an uncommon site for a leiomyoma.
  • [MeSH-major] Leiomyoma / pathology. Nose Neoplasms / pathology

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  • (PMID = 17909665.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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29. Chon SH, Lee CB, Shinn SH, Heo JN, Paik SS: Rib xanthoma resected by video-assisted thoracoscopic surgery using a bone punch. Surg Laparosc Endosc Percutan Tech; 2009 Feb;19(1):e15-6
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  • Xanthomas of the rib are extremely rare benign neoplasms, most commonly reported in soft tissue, but rarely in bone.
  • We report a case of a 4-cm xanthoma of the rib resected by video-assisted thoracoscopic surgery and pulled through a 2-cm port incision around the patient's areola.
  • To the best of our knowledge, there are only 8 other such cases, and none of which were removed by thoracoscopic surgery.
  • [MeSH-major] Bone Neoplasms / surgery. Ribs / surgery. Thoracic Surgery, Video-Assisted. Xanthomatosis / surgery

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  • (PMID = 19238049.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Levy AD, Patel N, Dow N, Abbott RM, Miettinen M, Sobin LH: From the archives of the AFIP: abdominal neoplasms in patients with neurofibromatosis type 1: radiologic-pathologic correlation. Radiographics; 2005 Mar-Apr;25(2):455-80
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  • [Title] From the archives of the AFIP: abdominal neoplasms in patients with neurofibromatosis type 1: radiologic-pathologic correlation.
  • Mutations of the NF1 gene lead to abnormal tumor suppression.
  • Consequently, patients with NF1 have an increased prevalence of benign and malignant neoplasms throughout the body.
  • There are five categories of NF1 tumors that occur in the abdomen: neurogenic, neuroendocrine, nonneurogenic gastrointestinal mesenchymal, embryonal, and miscellaneous.
  • Many of these tumors are age related, occur at specific anatomic locations, and have unique imaging features.
  • Notably, many patients have a variety of organs affected because there is a high prevalence of multiple tumors occurring in the same patient.
  • Neurofibromas are the most common benign neoplasms and may occur in the retroperitoneum or visceral organs.
  • Malignant peripheral nerve sheath tumor is an aggressive malignancy that is the most common malignant tumor of the abdomen in patients with NF1.
  • Interpreting abdominal imaging studies in patients with NF1 can be challenging because of the wide spectrum and diverse nature of tumors that occur in this disease.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Neurofibromatosis 1 / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Nerve Sheath Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis. Neurofibroma / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 15798063.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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31. Amaro C, Freitas I, Lamarão P, Afonso A, Skrzypczak M, Heinritz W: Multiple trichoepitheliomas--a novel mutation in the CYLD gene. J Eur Acad Dermatol Venereol; 2010 Jul;24(7):844-6
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  • BACKGROUND: Trichoepitheliomas are benign neoplasms with follicular differentiation.
  • OBJECTIVE: The authors report the case of a 9-year-old African girl with multiple facial trichoepitheliomas in whom a mutation in the CYLD gene was hypothesised.
  • RESULTS: A novel heterozygous mutation in exon 18 of the CYLD gene (c.2449delT) was identified, with a deletion of one nucleotide resulting in a premature translational termination codon at amino acid position 831 on the affected allele (p.Cys817Valfs X15).
  • [MeSH-major] Mutation. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 19929939.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins; 9007-49-2 / DNA
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32. Lee DH, Lee SH, Sung JK: Inflammatory myofibroblastic tumor on intercostal nerve presenting as paraneoplastic pemphigus with fatal pulmonary involvement. J Korean Med Sci; 2007 Aug;22(4):735-9
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  • [Title] Inflammatory myofibroblastic tumor on intercostal nerve presenting as paraneoplastic pemphigus with fatal pulmonary involvement.
  • Inflammatory myofibroblastic tumors (IMTs) are benign neoplasms that can occur at different anatomic sites with nonspecific clinical symptoms.
  • A 48-yr-old woman presented with a 2-month history of a relapsed oral ulcer, progressive dyspnea, and a thoracic pain induced by breathing.
  • A tumorous mass was noticed in the right costodiaphragmatic recess on chest computed tomography and magnetic resonance imaging, and the patient underwent a right costotransversectomy with excision of the tumor, which originated from the 12th intercostal nerve.
  • Histology and immunohistochemistry showed that the tumor was an IMT of the intercostal nerve.
  • The patient's postoperative course was not favorable; dyspnea persisted after surgery, and a progressive pulmonary compromise developed.
  • A brief review of the heterogeneous theories concerning the pathogenesis, clinicopathological features, and differential diagnosis of this disease entity is presented.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Intercostal Nerves / pathology. Paraneoplastic Syndromes / pathology. Pemphigus / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Female. Humans. Lung Diseases / etiology. Lung Diseases / pathology. Middle Aged

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  • [Cites] Chest. 2000 Feb;117(2):603-7 [10669715.001]
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  • (PMID = 17728520.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2693830
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33. Ba-Ssalamah A, Zacherl J, Noebauer-Huhmann IM, Uffmann M, Matzek WK, Pinker K, Herold C, Schima W: Dedicated multi-detector CT of the esophagus: spectrum of diseases. Abdom Imaging; 2009 Jan-Feb;34(1):3-18
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  • Multi-detector computed tomography (CT) offers new opportunities in the imaging of the gastrointestinal tract.
  • Its ability to cover a large volume in a very short scan time, and in a single breath hold with thin collimation and isotropic voxels, allows the imaging of the entire esophagus with high-quality multiplanar reformation and 3D reconstruction.
  • In contrast to endoscopy and double-contrast studies of the upper GI tract, CT provides information about both the esophageal wall and the extramural extent of disease.
  • In addition, MDCT allows detection of other esophageal malignancies, such as lymphoma and benign esophageal tumors, such as leiomyma.
  • A diagnosis of rupture or fistula of the esophagus can be firmly established using MDCT.
  • [MeSH-minor] Contrast Media. Esophageal Neoplasms / pathology. Esophageal Neoplasms / radiography. Humans. Imaging, Three-Dimensional. Neoplasm Staging. Radiographic Image Interpretation, Computer-Assisted

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  • (PMID = 17653787.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 43
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34. Silverman SG, Israel GM, Herts BR, Richie JP: Management of the incidental renal mass. Radiology; 2008 Oct;249(1):16-31
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  • Despite substantial advances in the imaging-based diagnosis of renal masses, the increased detection of incidental renal masses with cross-sectional imaging poses problems to the radiologist and referring physician.
  • In this article, the literature will be reviewed and an approach to the diagnosis and management of the incidental renal mass will be suggested.
  • However, additional imaging, and in selected patients, percutaneous biopsy, is recommended to diagnose benign neoplasms.
  • [MeSH-major] Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Comorbidity. Female. Humans. Kidney Diseases, Cystic / classification. Kidney Diseases, Cystic / diagnosis. Kidney Diseases, Cystic / therapy. Life Expectancy. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • [Copyright] (c) RSNA, 2008.
  • (PMID = 18796665.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 102
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35. de Vicente Rodríguez JC, Fresno Forcelledo MF, González García M, Aguilar Andrea C: Sebaceous adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal; 2006 Aug;11(5):E446-8
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  • Tumors of the salivary glands constitute an important field of oral and maxillofacial pathology.
  • The majority of salivary gland neoplasms are benign, with malignant salivary tumors accounting for 15 to 32 percent.
  • The most common site for salivary gland tumors is the parotid gland, accounting up to 80 percent of all cases.
  • This article reports the pathologic picture in a case of sebaceous adenoma of the parotid gland.
  • The tumor was composed of epithelial cells lining ducts and closely associated with broad areas of sebaceous differentiation.
  • The presence of sebaceous glands in salivary neoplasms is frequent, however, and in spite of this, salivary neoplasms constituted partially or entirely of these cells are rarely observed.
  • To the surgeon and pathologist, the major problem in dealing with sebaceous adenoma is the recognition of this rare entity, avoiding confusing with other more aggressive neoplasms.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16878064.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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36. Shetty C, Avinash KR, Auluck A: Schwannoma of vagus nerve masquerading as a parotid tumour. Dentomaxillofac Radiol; 2006 Sep;35(5):376-9
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  • [Title] Schwannoma of vagus nerve masquerading as a parotid tumour.
  • A post-auricular swelling is the most common presentation of a parotid tumour, the majority of which are benign neoplasms like pleomorphic adenoma.
  • This case report discusses a post-styloid parapharyngeal space tumour presenting as a post-auricular mass which, on initial clinical and cytological examination, was diagnosed as pleomorphic adenoma.
  • A radiological differential diagnosis is also discussed.
  • [MeSH-major] Cranial Nerve Neoplasms / radiography. Neurilemmoma / radiography. Vagus Nerve Diseases / radiography
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Parotid Neoplasms / diagnosis. Pharynx / radiography. Tomography, Spiral Computed

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  • (PMID = 16940487.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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37. Seseke S, Schweyer S, Reissig K, Seseke F: [Leiomyoma of the urethra - cause of an obstruction misdiagnosed as hereditary urethral stricture in a young man]. Aktuelle Urol; 2008 Mar;39(2):150-1
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  • [Title] [Leiomyoma of the urethra - cause of an obstruction misdiagnosed as hereditary urethral stricture in a young man].
  • Leiomyomas are benign neoplasms arising from smooth muscle cells.
  • We describe the case of a 17-year-old boy admitted with progressive severe obstructive voiding symptoms.
  • Histopathological examination confirmed the very rare case of a leiomyoma of the urethra.
  • [MeSH-major] Leiomyoma / complications. Urethral Neoplasms / complications. Urethral Stricture / etiology

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  • (PMID = 18379970.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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38. Salles VJ, Marotta A, Netto JM, Speranzini MB, Martins MR: Bile duct hamartomas--the von Meyenburg complex. Hepatobiliary Pancreat Dis Int; 2007 Feb;6(1):108-9
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  • Hamartomas of the bile duct (von Meyenburg complex) are benign neoplasms of the liver, constituted histologically cystic dilatations of the bile duct, encompassed by fibrous stroma.
  • Magnetic resonance imaging and liver biopsy are the gold standards for diagnosis of this rare hepatobiliary condition.

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  • (PMID = 17287178.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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39. Wüstenberg EG, Offergeld C, Zahnert T, Hüttenbrink KB, Kittner T: Extension of intracranial thrombosis after unilateral dissection of the internal jugular vein. Arch Otolaryngol Head Neck Surg; 2005 May;131(5):430-3
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  • OBJECTIVE: Resection of the internal jugular vein can be necessary in cases of radical neck dissection or even in cases involving benign neoplasms such as glomus tumors.
  • According to the triad described by Virchow (ie, stasis of blood flow, damage to the endothelium, and changes in hemostasis), the development of a thrombosis in the venous vessels superior to the resected internal jugular vein seems to be possible.
  • Sixteen patients had malignant tumors, and 1 patient had a glomus tumor.
  • After unilateral radical neck dissection, the venous blood leaves the brain mainly via the venous system of the other side of the neck and the ipsilateral collateral veins.

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  • (PMID = 15897422.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Radlinsky MG: Thyroid surgery in dogs and cats. Vet Clin North Am Small Anim Pract; 2007 Jul;37(4):789-98, viii
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  • Thyroid surgery is indicated for malignant and benign neoplasms or hyperplasia of the thyroid glands.

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  • (PMID = 17619012.001).
  • [ISSN] 0195-5616
  • [Journal-full-title] The Veterinary clinics of North America. Small animal practice
  • [ISO-abbreviation] Vet. Clin. North Am. Small Anim. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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41. Mascarenhas F, Costa MS, Ortiz M, Almeida A, Carvalho H, Ferreira AG, Cattoni MB: [Stereotactic radiosurgery in the intracranial benign neoplasms and malignant tumors of the brain]. Acta Med Port; 2005 Jan-Feb;18(1):45-60
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  • [Title] [Stereotactic radiosurgery in the intracranial benign neoplasms and malignant tumors of the brain].
  • Stereotactic Radiosurgery has proven to be during the last years the therapy of choice in more and more patients with benign and malignant brain tumors.
  • This series presents the experience of treating more than 100 intracranial lesions with linear accelerator-based radiosurgery at Hospital de Santa Maria in Lisbon with special emphasis on the indications and results.
  • It also provides a review of the concepts and procedures of this modality as well as a general overview of the main published results in series of patients with brain tumors treated with stereotactic radiosurgery.
  • [MeSH-major] Brain Neoplasms / surgery. Radiosurgery

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  • (PMID = 16202334.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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42. Dhingra KK, Setia N, Khurana N: A rare case of congenital nasopharyngeal teratoma presenting with respiratory distress. Indian J Otolaryngol Head Neck Surg; 2010 Sep;62(3):329-31
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  • Teratomas of the head and neck are rare, benign neoplasms, usually presenting in the neonatal period and are often malignant with regard to their location.

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  • (PMID = 23120736.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450234
  • [Keywords] NOTNLM ; Congenital / Nasopharyngeal / Teratoma
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43. Velusamy A, Saw S, Gossage J, Bailey S, Schofield J: Combined adenocarcinoid and mucinous cystadenoma of the appendix: a case report. J Med Case Rep; 2009;3:28
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  • INTRODUCTION: Adenocarcinoid of the appendix is a rare malignant tumour with features of both adenocarcinoma and carcinoid, showing both epithelial and endocrine differentiation.
  • Mucinous cystadenoma is the commonest of the benign neoplasms of the appendix, with an incidence of 0.6% in appendicectomy specimens.
  • Right hemicolectomy is generally advised if any of the following features are present: tumours greater than 2 cm, involvement of resection margins, greater than 2 mitoses/10 high-power fields on histology, extension of tumour beyond serosa.

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  • (PMID = 19171048.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2647933
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44. Garrido-Ruiz MC, Carrillo R, Enguita AB, Peralto JL: Signet-ring cell dermatofibroma. Am J Dermatopathol; 2009 Feb;31(1):84-7
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  • Dermatofibroma or cutaneous fibrous histiocytoma is a common benign skin lesion with multiple, distinct histologic variants, including cellular, aneurismal, epithelioid, atypical, lipidized "ankle-type," palisading, and cholesterotic.
  • Although dermatofibromas are considered benign neoplasms, certain variants including cellular and aneurismal ones have shown to have a notable tendency to locally recur after excision.
  • The finding of signet-ring cells in a skin neoplasm always raises the suspicion of metastatic adenocarcinoma, although a number of reports have shown their occurrence in primitive cutaneous neoplasms as well.
  • We present, for the first time, a new, distinctive variant of dermatofibroma, so-called signet-ring cell dermatofibroma, in a 16-year-old man with a slowly growing skin tumor on the lateral side of his right leg.
  • Histochemical and immunohistochemical stainings confirmed the diagnosis of dermatofibroma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19155733.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Koseoglu RD, Parlaktas BS, Filiz NO, Erdemir F, Uluocak N, Tulunay O: Adenocarcinoma originating from a mature teratoma of the testis. Kaohsiung J Med Sci; 2007 May;23(5):265-8
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  • Although testicular teratomas in childhood are regarded as benign neoplasms, these tumors, if left untreated until advanced ages, may present the risk of malignant transformation.
  • [MeSH-major] Adenocarcinoma / pathology. Teratoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 17525010.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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46. Pereira PD, Lopes CC, Matos AJ, Cortez PP, Gärtner F, Medeiros R, Lopes C: Caveolin-1 in diagnosis and prognosis of canine mammary tumours: comparison of evaluation systems. J Comp Pathol; 2010 Aug-Oct;143(2-3):87-93
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  • [Title] Caveolin-1 in diagnosis and prognosis of canine mammary tumours: comparison of evaluation systems.
  • Results obtained with both scoring methods were similar, revealing absence of immunoreactivity in normal luminal epithelium and in benign neoplasms and clearly associating Cav-1 expression with malignant transformation.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma / veterinary. Caveolin 1 / metabolism. Dog Diseases / diagnosis. Mammary Glands, Animal / metabolism. Mammary Neoplasms, Animal / diagnosis
  • [MeSH-minor] Animals. Caveolae / metabolism. Dogs. Female. Immunohistochemistry. Neoplasm Invasiveness. Neoplasm Metastasis. Prognosis. Research Design. Survival Analysis

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20153868.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Caveolin 1
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47. Viswanathan S, George S, Ramadwar M, Shet T, Arora B, Laskar S, Qureshi S, Medhi S, Muckaden MA, Kurkure PA, Kane SV, Banavali S: Extraconal orbital tumors in children--a spectrum. Virchows Arch; 2009 Jun;454(6):703-13
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  • [Title] Extraconal orbital tumors in children--a spectrum.
  • We analyzed 47 specimens comprising biopsies, excision specimens, and FNAC of extraconal pediatric orbital masses (excluding retinoblastoma) accessioned in the pathology department over 5 years in a tertiary referral cancer center.
  • The chief presenting symptom was proptosis in 55.3% patients and radiologically 53.8% malignant tumors showed extraorbital extension.
  • Malignant round cell tumors (76.6%), chiefly embryonal rhabdomyosarcoma (51%), benign spindle cell neoplasms, and infectious lesions (tuberculosis, fungal infections), were seen.
  • Of the malignant tumors, those confined to the orbit achieved good treatment response and had an event-free follow-up while those with extraorbital spread had poor outcome.
  • Pediatric orbital masses range from completely treatable infectious lesions, surgically resectable benign neoplasms to aggressive malignancies requiring chemotherapy and radiotherapy.
  • Pathologists play a key role in distinguishing these on small biopsy material and expediating accurate treatment thus saving the vision or life of a patient.
  • [MeSH-major] Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Algorithms. Biomarkers, Tumor / analysis. Child. Child, Preschool. Exophthalmos / diagnosis. Female. Humans. Infant. Male. Mycoses / diagnosis. Mycoses / therapy. Rhabdomyosarcoma, Embryonal / chemistry. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / secondary. Tuberculosis / diagnosis. Tuberculosis / therapy

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  • [Cites] Ophthalmology. 2004 May;111(5):997-1008 [15121380.001]
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  • (PMID = 19421774.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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48. McBride SM, Haas-Kogan DA: Nutrient-sensitive, antagonistically pleiotropic genes and their contribution to malignant behavior. Med Hypotheses; 2008;70(2):444-53
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  • Consequently, we reasoned that the initiating genetic lesions seen in some of the Phakomatoses, disorders associated with predominantly benign neoplasms, may somehow fundamentally limit malignant behavior (invasion and metastasis).
  • We argue that inactivating mutations in these genes (labeled RPPMs: repressors of proliferation/promoters of motility) results in predominantly benign growths because, while such mutations promote unconstrained proliferation, they limit the ability of neoplastic cells to migrate and invade.
  • Such pleiotropy may represent an evolutionarily conserved strategy designed to limit the spread of nascent neoplasias.
  • When not inactivated, we show how selective pressures in the tumor microenvironment would suppress mutation in these genes during progression and how wild-type RPPMs may function synergistically with oncogenes to promote malignant behavior.
  • Finally, we explore how this model may help to explain oncogene addiction, tumor dormancy, and spontaneous regression.
  • [MeSH-major] Neoplasms / genetics
  • [MeSH-minor] Animals. Cell Movement / genetics. Humans. Models, Biological. Mutation. Neoplasm Invasiveness / genetics. Neoplasm Metastasis / genetics. Oncogenes. Polymorphism, Genetic. Tuberous Sclerosis / genetics

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  • (PMID = 17689876.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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49. Grady WM: Epigenetic events in the colorectum and in colon cancer. Biochem Soc Trans; 2005 Aug;33(Pt 4):684-8
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  • Colon cancers arise from benign neoplasms and evolve into adenocarcinomas through a stepwise histological progression sequence, proceeding from either adenomas or hyperplastic polyps/serrated adenomas.
  • CGI DNA methylation is an epigenetic mechanism that represses gene transcription in normal cellular processes, but it becomes excessive and aberrant in many neoplasms.
  • These hypermethylated genes are not only probable pathogenic events affecting colon-cancer formation, but also neoplasm-specific molecular events that may be useful as molecular markers for colon tumours.
  • Furthermore, aberrant DNA methylation of tumour-suppressor genes may occur secondary to a genetic predisposition or to a field-cancerization effect in the colon and may be useful as molecular markers for the risk of developing colon cancer.
  • [MeSH-major] Colon / physiology. Colonic Neoplasms / genetics. Epigenesis, Genetic / genetics. Rectum / physiology

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  • (PMID = 16042574.001).
  • [ISSN] 0300-5127
  • [Journal-full-title] Biochemical Society transactions
  • [ISO-abbreviation] Biochem. Soc. Trans.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Number-of-references] 33
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50. Müller CS, Tilgen W, Kutzner H, Pföhler C: Recurring mixed-type neurothekeoma of the face. Dermatoendocrinol; 2009 Jul;1(4):220-2
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  • BACKGROUND: Neurothekeomas are rare, benign neoplasms, typically occurring in younger patients with a remarkable predilection for the female population.
  • The nomenclature and derivation of these tumors is controversial.
  • The rarity of this unusual skin tumor in daily routine histopathologic findings prompted the following report.
  • Multiple treatments with laser surgery were performed and yielded no persistent remission of the tumor.
  • Histopathologic examination revealed a non-encapsulated dermal tumor, composed of multiple, closely situated medium-sized nodules, separated by a myxoid collagenrich stroma, without epidermal alteration.
  • In summary, due to the histoarchitecture and immunoprofile of the tumor, a mixed-type cellular neurothekeoma was diagnosed.
  • The aim of this report is to help to avoid misdiagnoses of malignant mesenchymal tumors with serious consequences, including extensive surgical therapy or radiation.

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  • (PMID = 20592794.001).
  • [ISSN] 1938-1980
  • [Journal-full-title] Dermato-endocrinology
  • [ISO-abbreviation] Dermatoendocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2835878
  • [Keywords] NOTNLM ; cellular / nerve sheath tumor / neurothekeoma / skin / soft tissue tumor
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51. Sanz OA, Martinez PR, Guarch RT, Goñi MJ, Alcazar JL: Bilateral Leydig cell tumour of the ovary: a rare cause of virilization in postmenopausal patient. Maturitas; 2007 Jun 20;57(2):214-6
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  • [Title] Bilateral Leydig cell tumour of the ovary: a rare cause of virilization in postmenopausal patient.
  • BACKGROUND: Leydig cell tumours of the ovary are very rare benign neoplasms, frequently associated with symptoms of virilisation, in postmenopausal patients.
  • A 77-year-old postmenopausal patient was referred from the Endocrinology Service due to a biochemical diagnosis of hyperandrogenism during hospital admission with unbalanced diabetes mellitus.
  • A CT scan demonstrated adrenal glands and ovaries without tumour.
  • RESULT: The pathological finding was a bilateral Leydig cell tumour, measuring 15 mm in the right ovary and 3 mm in the left ovary.
  • [MeSH-major] Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Virilism / etiology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Postmenopause

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  • (PMID = 17289310.001).
  • [ISSN] 0378-5122
  • [Journal-full-title] Maturitas
  • [ISO-abbreviation] Maturitas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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52. Woertler K: Soft tissue masses in the foot and ankle: characteristics on MR Imaging. Semin Musculoskelet Radiol; 2005 Sep;9(3):227-42
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  • Benign neoplasms and tumor-like lesions constitute the majority of soft tissue masses in the foot and ankle.
  • Therefore, malignant tumors are often unsuspected at this site and misdiagnosed clinically, especially if occurring in young individuals with unspecific or long-standing clinical symptoms.
  • In addition to radiography, MR imaging represents the method of choice in evaluation of foot tumors.
  • Because of their relatively characteristic imaging appearance, in most cases of benign soft tissue lesions of the foot and ankle a specific diagnosis can be suggested.
  • Unfortunately, malignant tumors can also arise with nonaggressive imaging features.
  • This article reviews the MR appearance of the most common benign and malignant soft tissue masses in the foot and ankle together with their clinical, radiographic, and pathological findings.
  • [MeSH-major] Ankle. Foot Diseases / diagnosis. Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Angiomyoma / diagnosis. Chondroma / diagnosis. Chondromatosis, Synovial / diagnosis. Fibroma / diagnosis. Fibromatosis, Aggressive / diagnosis. Fibrosis / diagnosis. Ganglion Cysts / diagnosis. Hemangioma / diagnosis. Humans. Lipoma / diagnosis. Sarcoma, Clear Cell / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis

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  • (PMID = 16247723.001).
  • [ISSN] 1089-7860
  • [Journal-full-title] Seminars in musculoskeletal radiology
  • [ISO-abbreviation] Semin Musculoskelet Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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53. Lerman M, Freedman PD: Nonneural granular cell tumor of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar;103(3):382-4
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  • [Title] Nonneural granular cell tumor of the oral cavity: a case report and review of the literature.
  • Nonneural granular cell tumors (NNGCTs) are rare benign neoplasms originally described in 1991 by Leboit et al.
  • Typical granular cell tumors (GCTs) are commonly encountered in the oral cavity, but NNGCTs, unlike GCTs, are S-100 negative and may display cytologic atypia, allowing for misdiagnosis as a more aggressive lesion.
  • We report a case of a 43-year-old male with a lesion of the mandible that we believe to be the first intraoral example of an NNGCT.
  • [MeSH-major] Granular Cell Tumor / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17321450.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD63 protein, human; 0 / CD68 antigen, human; 0 / Platelet Membrane Glycoproteins
  • [Number-of-references] 9
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54. Lasota J, Wang ZF, Sobin LH, Miettinen M: Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases. Mod Pathol; 2009 Aug;22(8):1049-56
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  • [Title] Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases.
  • The inflammatory fibroid polyp is a rare benign lesion occurring throughout the digestive tract.
  • There were 26 deletions, three deletion-insertions, duplication, and single nucleotide substitution in exon 12, and a single nucleotide substitution and deletion in exon 18.
  • However, 1835_1852delinsCGC leading to the same S566_E571delinsR, were found in two tumors.
  • Similar gain-of-function PDGFRA mutations reported in gastrointestinal stromal tumors have been considered to be a driving pathogenetic force.
  • This study showed consistent expression and common mutational activation of PDGFRA in small intestinal inflammatory fibroid polyps as in their gastric counterparts, and these lesions should be considered PDGFRA-driven benign neoplasms.
  • [MeSH-major] Biomarkers, Tumor / genetics. Intestinal Neoplasms / genetics. Intestinal Polyps / genetics. Leiomyoma / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. Female. Gastrointestinal Stromal Tumors / genetics. Humans. Immunohistochemistry. Intestine, Small / pathology. Male. Middle Aged. Mutation. Polymerase Chain Reaction. Young Adult

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  • (PMID = 19448595.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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55. Akgün RC, Güler UÖ, Onay U: A glomus tumor anterior to the patellar tendon: a case report. Acta Orthop Traumatol Turc; 2010;44(3):250-3
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  • [Title] A glomus tumor anterior to the patellar tendon: a case report.
  • Glomus tumors are benign neoplasms originating from the glomus body.
  • They are most frequently found in the nail bed of the hands, and their occurrence in other parts of the body is rare.
  • Plain radiographs showed no pathology other than mild degenerative changes.
  • The mass was excised and the histopathological diagnosis was reported as glomangioma.
  • [MeSH-major] Glomus Tumor / diagnosis. Patellar Ligament
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 21088468.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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56. Marulaiah M, Gilhotra A, Moore L, Boucaut H, Goh DW: Testicular and paratesticular pathology in children: a 12-year histopathological review. World J Surg; 2010 May;34(5):969-74
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  • In all, 442 patients had non-neoplastic pathology, with 60.4% presenting acutely.
  • The most common non-neoplastic pathologies were hydatid of Morgagni (42.6%) and "vanishing testis" (14.3%).
  • A total of 32 patients had neoplasms.
  • Of 27 patients with testicular neoplasms, 55.6% were malignant (29.6% primary and 26% secondary), the principal primary malignancy was yolk sac tumor; the most common benign neoplasms were epidermoid cysts and teratomas.
  • Five patients had paratesticular neoplasms, with rhabdomyosarcoma in 80%.
  • CONCLUSIONS: The variety of scrotal and testicular pathology in children is considerable, with acute pathologic conditions comprising the bulk in the older (7-15 years) children, whereas impalpable testes and neoplasms comprise most of the lesions in infants.
  • Benign testicular neoplasms occur more frequently than primary malignancies.

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  • (PMID = 20151127.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Henning JS, Firoz BF: Combat dermatology: the prevalence of skin disease in a deployed dermatology clinic in Iraq. J Drugs Dermatol; 2010 Mar;9(3):210-4
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  • [Title] Combat dermatology: the prevalence of skin disease in a deployed dermatology clinic in Iraq.
  • The most prevalent diagnoses included eczematous dermatitis [17%, n=462] and benign neoplasms [14%, n=375].
  • CONCLUSION: This is the largest publication of the prevalence of skin disease in an exclusively dermatologic clinic in a combat setting.
  • For the first time the presence of skin cancer is noted in a combat setting.
  • [MeSH-minor] Adolescent. Adult. Aged. Eczema / epidemiology. Female. Humans. Iraq War, 2003-2011. Male. Middle Aged. Prevalence. Skin Diseases, Infectious / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 20232580.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Pieta B, Opala T, Wilczak M, Grodecka-Gazdecka S, Kramer L, Samulak D, Wieznowska-Maczyńska K: Past obstetric history and risk of malignant breast neoplasms. Eur J Gynaecol Oncol; 2008;29(4):374-7
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  • [Title] Past obstetric history and risk of malignant breast neoplasms.
  • They are also probably responsible for the development of benign neoplasms and play a role in the origin and development of breast carcinoma.
  • The purpose of the study was to analyze the obstetrical past of patients and the potential influence on the risk of developing malignant breast neoplasms.
  • The participants in the study were healthy women with no changes in mammary glands (control group) and women with diagnosed malignant or benign breast neoplasms (study group).
  • Hormonal disorders in childhood and puberty symptoms of early menarche play a crucial role in increasing the risk of malignant breast neoplasms.
  • In women who experienced one or more miscarriages the risk of malignant breast neoplasms is significantly increased.
  • On the basis of our study we calculated the odds ratio (OR) of malignant breast neoplasms among women who during lactation experienced problems needing medical intervention (OR = 2.25; 95% CI, 1.20-4.19) in comparison to women who experienced no problems).
  • [MeSH-major] Breast Neoplasms / epidemiology. Reproductive History

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  • (PMID = 18714573.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Estrogens
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59. Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M: Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol; 2009 May;33(5):705-19
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  • [Title] Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome.
  • The authors present a series of 24 malignant neoplasms arising in preexisting benign spiradenoma (20), cylindroma (2), and spiradenocylindroma (2).
  • Nineteen patients (12 females, 7 males; age range, 41 to 92 y) had a solitary neoplasm (size range, 2.2 to 17.5 cm; median 4 cm), whereas the remaining 5 (4 females, 1 male; age range, 66 to 72 y) manifested clinical features of Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease characterized by widespread, small, benign neoplasms on which background larger malignant lesions appeared.
  • Microscopically, all cases showed the residuum of a preexisting benign neoplasm.
  • 3) invasive adenocarcinoma, not otherwise specified (IAC-NOS); and 4) sarcomatoid (metaplastic) carcinoma.
  • In 1 case of IAC-NOS, an in situ adenocarcinoma was also found, presumed to have evolved from an adjacent adenomatous and atypical adenomatous component.
  • Cases harboring a sarcomatoid carcinoma featured a malignant epithelial component composed of varying combinations of BCAC-HG, BCAC-LG, IAC-NOS, or squamous cell carcinoma, whereas the sarcomatoid component appeared as either a pleomorphic or spindle-cell sarcoma.
  • Of the 21 patients with available follow-up (range, 3 mo-15 y; average 4.8 y; median 3.5 y), 10 were without evidence of disease, 1 was alive with metastatic disease, 1 was alive with BSS, 3 developed local recurrences, 4 had died of disease, and 2 were dead of other causes.
  • The histologic pattern of the malignant neoplasm correlated to some extent with the clinical course.
  • BCAC-LG neoplasms showed a less aggressive course, with local recurrences but no distant metastases, whereas the BCAC-HG neoplasms typically followed a highly aggressive course resulting in the death 3 of 6 patients with BCAC-HG.
  • Given the morphologic diversity and complexity of the neoplasms in question, we propose using a more specific terminology with the precise description of the neoplasm components, rather than generic and less informative terms such as "spiradenocarcinoma" or "carcinoma ex cylindroma. "
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Australia. Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Cell Differentiation. Chromosomes, Human, Pair 16. Europe. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged. Mutation. Neoplasm Invasiveness. South Africa. Syndrome. Treatment Outcome. Tumor Suppressor Proteins / genetics


60. Strong VE, Kennedy T, Al-Ahmadie H, Tang L, Coleman J, Fong Y, Brennan M, Ghossein RA: Prognostic indicators of malignancy in adrenal pheochromocytomas: clinical, histopathologic, and cell cycle/apoptosis gene expression analysis. Surgery; 2008 Jun;143(6):759-68
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  • The histologic differentiation between benign and malignant tumors is difficult, the latter diagnosed by the presence of metastatic disease or recurrence.
  • A senior endocrine pathologist, blinded to clinical outcome, reviewed the histopathologic characteristics of all cases using the PASS system.
  • This pheochromocytoma scoring system is based on the presence of 12 different histologic parameters, including tumor necrosis, mitotic rate, tumor cell spindling, and the presence of large cell nests.
  • In addition, we constructed a tissue microarray of all 5 malignant tumors and 41 of the benign tumors.
  • RESULTS: Forty-three patients had a benign clinical course while 5 patients harbored a clinically malignant pheochromocytoma.
  • Tumor necrosis (focal or confluent) was a particularly powerful indicator of malignancy present in 4 of 5 patients (80%) with malignant tumors, but only in 3 of 42 cases (7%) with benign neoplasms (P = .0009).
  • The presence of a high mitotic rate (>3/10 high power fields) and tumor cell spindling significantly correlated with malignancy (P = .026 and .041, respectively).
  • There was a highly significant difference in PASS scores between benign and malignant cases (P = .0003).
  • Two of the 4 patients testing positive for Ki-67 (>2% nuclear staining) had a clinically malignant course while only 3 (7%) of the 41 cases with lower Ki-67 positivity rate behaved in a malignant fashion (P = .055).
  • Ki-67-positive tumor had a significantly higher chance of harboring tumor necrosis than Ki-67-negative neoplasms (P < .01).
  • There was no difference in staining between benign and malignant pheochromocytomas using p53, Bcl-2, mdm-2, cyclin D1, p21, and p27. CONCLUSIONS:.
  • (1) A PASS score of <4 predicted benign pheochromocytomas. (2) All malignant pheochromocytomas had a PASS score >/=6, which was significantly higher compared with the benign lesions.
  • Ki-67 may help identify those neoplasms at risk for recurrence by prompting the pathologist to look aggressively for adverse histologic features.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / pathology. Apoptosis. Cell Cycle. Gene Expression Regulation, Neoplastic. Neoplasm Recurrence, Local / genetics. Pheochromocytoma / diagnosis. Pheochromocytoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / genetics. Ki-67 Antigen / metabolism. Male. Middle Aged. Necrosis / diagnosis. Necrosis / genetics. Necrosis / pathology. Predictive Value of Tests. Prognosis. Prospective Studies. Risk Factors. Severity of Illness Index. Single-Blind Method


61. Passman C, Urban D, Klemm K, Lockhart M, Kenney P, Kolettis P: Testicular lesions other than germ cell tumours: feasibility of testis-sparing surgery. BJU Int; 2009 Feb;103(4):488-91
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  • [Title] Testicular lesions other than germ cell tumours: feasibility of testis-sparing surgery.
  • OBJECTIVE: To review all non-germ-cell testicular lesions presenting at our institution and to determine the feasibility of testis-sparing surgery for these patients.
  • The study comprised men who had radical orchidectomy for suspected germ-cell tumour but had other final pathology, and those where testis-sparing surgery was attempted for a presumed benign lesion.
  • The lesions could be categorized as inflammatory (three hyalinized fibrosis, two sarcoidosis, one chronic inflammation), cystic (one epidermoid cyst, one unilocular cyst), benign neoplasms (two adenomatoid tumours, one Leydig cell tumour, one capillary haemangioma) or malignant neoplasms (one lymphoma).
  • In the other five, testis-sparing surgery was not attempted because the preoperative impression was that of a germ cell tumour.
  • CONCLUSION: Testis-sparing surgery might be possible if there is significant suspicion of a benign lesion.
  • [MeSH-minor] Adolescent. Adult. Aged. Feasibility Studies. Humans. Leydig Cell Tumor / pathology. Leydig Cell Tumor / surgery. Leydig Cell Tumor / ultrasonography. Male. Middle Aged. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18793303.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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62. Garg K, Lee P, Ro JY, Qu Z, Troncoso P, Ayala AG: Adenomatoid tumor of the adrenal gland: a clinicopathologic study of 3 cases. Ann Diagn Pathol; 2005 Feb;9(1):11-5
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  • [Title] Adenomatoid tumor of the adrenal gland: a clinicopathologic study of 3 cases.
  • Adenomatoid tumors are relatively uncommon benign neoplasms of mesothelial origin, usually occurring in the male and female genital tracts.
  • Rare extragenital adenomatoid tumors have been identified in the adrenal glands, heart, mesentery, pleura, and lymph nodes.
  • In the adrenal gland, adenomatoid tumors may pose a diagnostic challenge.
  • The differential diagnosis includes adrenocortical carcinoma and metastatic carcinoma, especially signet ring cell carcinoma.
  • Because of its glandular pattern, an adenomatoid tumor may be confused with an adenocarcinoma.
  • We present 3 cases of adrenal adenomatoid tumors, including one with a concurrent large hemorrhagic vascular adrenal cyst.
  • The adenomatoid tumors were unilateral, appeared solid and white, and varied from 1.7 to 4.2 cm in diameter.
  • One patient presented with abdominal pain due to the presence of a concurrent large adrenal cyst.
  • The tumor was an incidental radiological finding in another case and was discovered during the course of a workup for hypertension in the third case.
  • The light microscopic appearances were consistent with those of typical adenomatoid tumors.
  • Immunohistochemical stains for calretinin and cytokeratin 5/6 were positive, confirming the tumors' mesothelial origin.
  • In our experience, the key to the diagnosis of this rare benign tumor is to consider adenomatoid tumor in the differential diagnosis of any glandular tumor occurring in the adrenal gland.
  • [MeSH-major] Adenoma / pathology. Adrenal Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adult. Biomarkers, Tumor / metabolism. Calbindin 2. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Cysts / complications. Cysts / metabolism. Cysts / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. S100 Calcium Binding Protein G / metabolism. Treatment Outcome

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  • (PMID = 15692945.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 68238-35-7 / Keratins
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63. Novikov DV, Belova TV, Pegov RG, Aliasova AA, Morozova PN, Kniazev DI, Kalugin AV, Kontorshchikova KN, Baryshnikov AIu, Novikov VV: [Detection rate of MAGE-A1-A6 mRNA in the peripheral blood of cancer patients]. Klin Lab Diagn; 2009 Apr;(4):25-7
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  • The mRNA expression of 6 MAGE-A (MAGE-A1-A6) antigens by the tumor focal cells and cancer cells circulating in blood was studied in solid malignant and benign neoplasms.
  • MAGE- A1-A6 mRNA expression was detected in the tumor focal cells in more than 90% of cases of cancer of the breast, lung, and stomach and melanoma cell lines.
  • The detection rate of peripheral blood MAGE-A1-A6-positive tumor cells was 95% in lung cancer, 53% in corpus uteri cancer, 67% in gastric cancer, 63% in breast cancer, 33% in melanoma, and 42% in uterine myoma.
  • [MeSH-major] Biomarkers, Tumor / blood. Neoplastic Cells, Circulating / metabolism. RNA, Messenger / blood
  • [MeSH-minor] Antigens, Neoplasm / blood. Female. Humans. Melanoma-Specific Antigens. Neoplasm Proteins / blood. Neoplasms / blood

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  • (PMID = 19514330.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MAGEA3 protein, human; 0 / MAGEA4 protein, human; 0 / MAGEA6 protein, human; 0 / Mage-a2 antigen; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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64. Rakic S, Nikolic B, Dragojevic-Dikic S: Ovarian neoplasms and pregnancy. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1120-3
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  • [Title] Ovarian neoplasms and pregnancy.
  • The aim of our study was to investigate the incidence of ovarian malignant neoplasms in pregnancy.
  • We examined 37 pregnant women; the incidence of ovarian cancer was 13.5% vs 6.5% in other works.
  • Treatment depends on the neoplasms type, grade, and presence of the metastatic pathways.
  • In benign neoplasms, we used laparoscopic treatment with minor invasion.
  • Distribution of benign neoplasms was in the same range as that in other works.
  • [MeSH-major] Ovarian Neoplasms / epidemiology. Pregnancy Complications, Neoplastic / epidemiology

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  • (PMID = 16343192.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Ridder GJ, Behringer S, Kayser G, Pfeiffer J: [Malignancies arising in sinonasal inverted papillomas]. Laryngorhinootologie; 2008 Nov;87(11):783-90
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  • BACKGROUND: Inverted papillomas are primarily benign neoplasms that occur in the nasal cavity and paranasal sinuses.
  • However, neither the etiology and pathogenesis of these tumors nor the putative role as a precursor to carcinoma and the factors responsible for associated malignancy have been clarified.
  • PATIENTS AND METHODS: In a retrospective study we reviewed the charts of 93 patients with sinonasal inverted papillomas who were treated at our department between 1990 and 2007.
  • Comparison was made between the group of patients with inverted papillomas and associated squamous cell carcinomas and the group of patients with benign inverted papillomas.
  • Our data suggest, that the association between carcinoma and inverted papilloma is indirect and that the gradual progression from inverted papilloma to a malignant neoplasm is if at all infrequent.
  • [MeSH-major] Carcinoma, Squamous Cell. Neoplasms, Multiple Primary. Neoplasms, Second Primary. Nose Neoplasms. Papilloma, Inverted. Paranasal Sinus Neoplasms. Sphenoid Sinus
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Maxillary Sinus / pathology. Maxillary Sinus Neoplasms / pathology. Maxillary Sinus Neoplasms / surgery. Middle Aged. Neoplasm Staging. Nose / pathology. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 18633858.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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66. Chirieac LR, Dekmezian RH, Ayala AG: Characterization of the myxoid variant of hibernoma. Ann Diagn Pathol; 2006 Apr;10(2):104-6
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  • Hibernomas are rare benign neoplasms composed of brown adipose tissue.
  • In this report, we present and characterize the spectrum of morphological features of the myxoid variant of hibernoma by describing the case of a 45-year-old white man who was referred to our hospital for treatment of an ovoid mass in the posterior segment of the right deltoid region.
  • Histopathologic examination of the resected specimen revealed a multilobulated, tan-yellow, variegated tumor with a rubbery consistency that was separated by thick fibrous septa with interspersed collections of foamy histiocytes.
  • This report highlights recent advances that may help confirm the diagnosis and explain the differential diagnosis of this rare tumor.
  • This is one of only a few cases of a myxoid variant of hibernoma reported in the literature.
  • [MeSH-major] Lipoma / diagnosis. Shoulder Joint
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 16546046.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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67. Hirabayashi K, Yasuda M, Umemura S, Itoh H, Itoh J, Yazawa N, Imaizumi T, Osamura RY: Cytological features of the cystic fluid of pancreatic schwannoma with cystic degeneration. A case report. JOP; 2008;9(2):203-8
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  • CONTEXT: Schwannomas are benign neoplasms arising from peripheral nerve tissue.
  • We present the histological and cytological features of a pancreatic schwannoma with cystic degeneration.
  • CASE REPORT: A 51-year-old male was diagnosed with a cystic tumor measuring approximately 6 cm in the tail of the pancreas.
  • Cystic fluid from the tumor was obtained intraoperatively by fine-needle aspiration, and it showed scattered spindle tumor cells against a background of hemosiderin-laden histiocytes.
  • During the operation, we informed the surgeon that the tumor consisted of "atypical spindle cells".
  • Histologically, the tumor was diagnosed as a schwannoma with cystic degeneration which had originated in the pancreas.
  • The diagnosis was confirmed by positive immunostaining of the tumor cells in both histological and cytological materials for S-100 protein.
  • CONCLUSION: Problems occasionally arise with the use of fine-needle aspiration in the diagnosis of cystic diseases of the pancreas because of the difficulty in obtaining adequate specimens.
  • Nevertheless, it should be emphasized that intraoperative fine-needle aspiration is as informative as a frozen section diagnosis, when appropriately performed.
  • [MeSH-major] Cyst Fluid / cytology. Neurilemmoma / pathology. Pancreas / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18326930.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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68. Llauger J, Aixut S, Cañete N, Palmer J, Solà M, Bagué S: Meningioma of the scapula. Skeletal Radiol; 2008 Feb;37(2):169-71
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  • Meningiomas account for approximately 15% of all intracranial tumors and are the most common non-glial primary tumors of the central nervous system.
  • Most meningiomas are benign neoplasms with characteristic imaging features.
  • [MeSH-major] Bone Neoplasms / diagnosis. Meningioma / diagnosis. Scapula / diagnostic imaging. Scapula / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Rare Diseases. Shoulder Pain / etiology. Tomography, X-Ray Computed

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  • [Cites] AJNR Am J Neuroradiol. 2005 Sep;26(8):2053-6 [16155159.001]
  • [Cites] J Neurosurg. 2000 Dec;93(6):940-50 [11117866.001]
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  • (PMID = 18030466.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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69. Alvarez Ardura M, Hernández Cañas V, de la Morena Gallego JM, Rengifo Abbad D, González-Chamorro Ladrón de Guevara F, Llorente Abarca C: [Giant renal oncocytoma]. Actas Urol Esp; 2005 Sep;29(8):791-3
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  • Renal oncocytoma is a benign neoplasms arising from cells of the distal renal tubule.
  • They acount for 3-7% of all renal tumors. most are incidental findings.
  • Differential diagnosis with renal cells carcinoma is often difficult.
  • Here we report a case of big renal oncocytoma as an incidental finding while performing an abdominal ultrasound in a patient with low abdominal pain.
  • [MeSH-major] Adenoma, Oxyphilic / diagnostic imaging. Kidney Neoplasms / diagnostic imaging

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  • (PMID = 16304913.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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70. Zhou YA, Huang JH, Wan CY, Zuo ZB: [Surgical treatment and effect observation of cervical intraspinal benign neoplasms]. Zhongguo Gu Shang; 2009 Nov;22(11):856-8
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  • [Title] [Surgical treatment and effect observation of cervical intraspinal benign neoplasms].
  • OBJECTIVE: To investigate the diagnosis, surgical procedure and clinical outcome of cervical intraspinal benign neoplasm.
  • The tumors were removed completely in 18 cases, above 60% in 3 cases and 25% with biopsy in 1 case.
  • Cervical stability in 11 cases was restored after removal of tumors.
  • Symptoms improved in 20 cases and stable in 1 case and worsened in 1 case postoperatively according to JOA scoring system.
  • The average recover ratio of total was (46.7 +/- 2.46)%, cervical stability was (62.37 +/- 3.58)%, the other methods was (41.21 +/- 4.63)%.
  • CONCLUSION: The surgical exairesis for cervical intraspinal benign neoplasm has low post-operative recurrence.
  • The main reason of recurrence is not removed the tumor completely.
  • MRI is regarded the effective method which is helpful in differential diagnosis and surgery guidance.
  • [MeSH-major] Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery

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  • (PMID = 20084949.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Eskenazi B, Warner M, Samuels S, Young J, Gerthoux PM, Needham L, Patterson D, Olive D, Gavoni N, Vercellini P, Mocarelli P: Serum dioxin concentrations and risk of uterine leiomyoma in the Seveso Women's Health Study. Am J Epidemiol; 2007 Jul 1;166(1):79-87
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  • Uterine leiomyomata (fibroids), benign neoplasms of the smooth muscle, are a major cause of hysterectomy.
  • The authors investigated the risk of uterine leiomyoma associated with exposure to 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) for women who resided near Seveso, Italy, in 1976 at the time of a chemical explosion.
  • Compared with that for women with TCDD levels of < or = 20 parts per trillion, the age-adjusted hazard ratios were 0.58 (95% confidence interval: 0.41, 0.81) for women with levels of 20.1-75.0 parts per trillion and 0.62 (95% confidence interval: 0.44, 0.89) for women with levels of >75.0 parts per trillion.
  • [MeSH-major] Environmental Pollutants / adverse effects. Leiomyoma / chemically induced. Tetrachlorodibenzodioxin / adverse effects. Uterine Neoplasms / chemically induced. Women's Health

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  • (PMID = 17443023.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Grant] United States / FIC NIH HHS / TW / F06 TW02075-01; United States / NIEHS NIH HHS / ES / P30-ES001896-17; United States / NIEHS NIH HHS / ES / R01 ES07171
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Environmental Pollutants; DO80M48B6O / Tetrachlorodibenzodioxin
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72. Chung C, Forte AJ, Narayan D, Persing J: Giant nevi: a review. J Craniofac Surg; 2006 Nov;17(6):1210-5
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  • Congenital nevi are benign neoplasms that are present at birth and composed of nevomelanocytes.
  • Findings of a culture of melanocytes from such a lesion from a showed chromosome rearrangements involving 1p,12q, and 19p.
  • [MeSH-major] Nevus, Pigmented. Skin Neoplasms

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  • (PMID = 17119398.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 53
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73. Vernon SE, Casiano RR: Sphenoid sinus chondromyxoid fibroma mimicking a mucocele. Am J Otolaryngol; 2006 Nov-Dec;27(6):406-8
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  • We report the case of a 44-year-old man who presented with a chondromyxoid fibroma (CMF) of the sphenoid sinus, which filled the sinus and clinically and radiologically resembled a mucocele.
  • Chondromyxoid fibromas are the least common cartilaginous neoplasms of bone, typically occurring in the metaphysis of long bones.
  • Chondromyxoid fibroma displays a relatively unique histological appearance, with characteristic lobulation, with spindle to stellate cells embedded in a myxoid or chondroid matrix.
  • Although CMFs are generally regarded as benign neoplasms, they may show an infiltrative pattern and may recur, particularly when they are in locations where complete surgical excision may be difficult or impossible.
  • [MeSH-major] Fibroma / diagnosis. Mucocele / pathology. Paranasal Sinus Neoplasms / diagnosis. Sphenoid Sinus / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17084225.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Redman RS, Katuri V, Tang Y, Dillner A, Mishra B, Mishra L: Orofacial and gastrointestinal hyperplasia and neoplasia in smad4+/- and elf+/-/smad4+/- mutant mice. J Oral Pathol Med; 2005 Jan;34(1):23-9
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  • [Title] Orofacial and gastrointestinal hyperplasia and neoplasia in smad4+/- and elf+/-/smad4+/- mutant mice.
  • BACKGROUND: Smad4 is vital to the roles of Smads 2 and 3 in transforming growth factor-beta (TGF)-beta signal transduction, and inactivated Smad4 is common to human gastrointestinal cancers.
  • METHODS: Smad4+/- mice, known to develop gastrointestinal cancer, were crossbred with elf+/- mice.
  • RESULTS: In addition to polyps and adenocarcinomas of the stomach and duodenum, the smad4+/- mice developed squamous cell carcinomas of the skin, oral mucosa and forestomach, benign neoplasms of connective tissue and lacrimal gland, and a lymphoma.
  • The smad4+/-/elf+/- mice developed extensive hyperplasia and neoplasia of the gastric mucosa.
  • CONCLUSION: These findings indicate that investigating interactions among smad4, elf, and other genes involved in TGF-beta signaling should be useful in further delineating the processes of neoplasia in a wide variety of tissues.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. DNA-Binding Proteins / genetics. Neoplasms / genetics. Trans-Activators / genetics
  • [MeSH-minor] Animals. Female. Gastrointestinal Neoplasms / genetics. Hybridization, Genetic. Hyperplasia / genetics. Male. Mice. Mice, Mutant Strains. Mouth Neoplasms / genetics. Skin Neoplasms / genetics. Smad4 Protein

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  • (PMID = 15610403.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01DK56111; United States / NIDDK NIH HHS / DK / R01DK58637
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Smad4 Protein; 0 / Trans-Activators
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75. Chittiboina P, Zhang S, Bao J, Vannemreddy P, Guthikonda B: Subependymoma at the foramen of Monro presenting with intermittent hydrocephalus: case report and review of the literature. J La State Med Soc; 2010 Jul-Aug;162(4):214-7
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  • Subependymomas are benign neoplasms, accounting for 0.5 % of all central nervous system tumors.
  • These tumors are frequently asymptomatic, often discovered incidentally at autopsy.
  • However, patients may be symptomatic with the symptoms depending on location of the tumor.
  • We present a rare case report of a subependymoma at the foramen of Monro presenting with intermittent hydrocephalus.
  • The patient's tumor was asymptomatic for many years.
  • Even though our patient presented with a histologically benign ventricular tumor, she demonstrated rapidly worsening symptoms that culminated in herniation.
  • Once diagnosed, we recommend early tumor removal and restoration of normal cerebrospinal fluid (CSF) pathways for these intraventricular tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Cerebral Ventricles. Glioma, Subependymal / diagnosis. Hydrocephalus / etiology

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  • (PMID = 20882814.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Seow-Choen F: The management of desmoids in patients with familial adenomatous polyposis (FAP). Acta Chir Iugosl; 2008;55(3):83-7
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  • Desmoids are benign neoplasms that are capable of infiltrating locally with a high risk of recurrence (25-65%) even after extirpating surgery.

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  • (PMID = 19069698.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Serbia
  • [Number-of-references] 21
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77. Simaga S, Osmak M, Babic D, Sprem M, Vukelic B, Abramic M: Quantitative biochemical analysis of lactate dehydrogenase in human ovarian tissues: correlation with tumor grade. Int J Gynecol Cancer; 2005 May-Jun;15(3):438-44
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  • [Title] Quantitative biochemical analysis of lactate dehydrogenase in human ovarian tissues: correlation with tumor grade.
  • In an attempt to identify glycolytic capacity of normal and neoplastic human ovary, total lactate dehydrogenase (LDH) activity was measured in tissue cytosol originating from 69 patients (18 with benign ovarian tumor, 34 with ovarian carcinoma, six with nonepithelial ovarian malignant tumors, and 11 with tumor metastatic to ovary) and compared to the LDH activity of normal ovarian tissues (n = 19).
  • Median value of total LDH-specific activity expressed as U/mg protein was 0.546 in normal tissues, 0.584 in benign tumors, 1.071 in malignancies metastatic to ovaries, 0.872 in nonepithelial primary ovarian tumors, and 0.818 in primary carcinomas.
  • A significant rise in LDH-specific activity was found in malignant primary and secondary tumors of epithelial and nonepithelial origin, but not in benign neoplasms, compared to the activity in normal tissue.
  • Ovarian carcinomas of serous histologic type did not differ in LDH activity from mucinous tumors.
  • The subgroup of grade 1 tumors did not differ in LDH activity from normal and benign ovarian tissue.
  • Obtained results suggest that direct correlation might exist between ovarian epithelial tumor grade and lactate dehydrogenase activity.
  • [MeSH-major] L-Lactate Dehydrogenase / analysis. L-Lactate Dehydrogenase / metabolism. Ovarian Neoplasms / enzymology. Ovarian Neoplasms / pathology. Ovary / enzymology

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  • (PMID = 15882167.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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78. Manjunatha HK, Ramaswamy AS, Kumar BS, Kumar SP, Krishna L: Lipoleiomyoma of uterus in a postmenopausal woman. J Midlife Health; 2010 Jul;1(2):86-8
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  • [Title] Lipoleiomyoma of uterus in a postmenopausal woman.
  • Lipoleiomyomas are uncommon benign neoplasms of uterus and are considered to be a variant of uterine myomas.
  • These tumors generally occur in asymptomatic obese perimenopausal or menopausal women.

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  • (PMID = 21716761.001).
  • [ISSN] 0976-7819
  • [Journal-full-title] Journal of mid-life health
  • [ISO-abbreviation] J Midlife Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3122497
  • [Keywords] NOTNLM ; Lipoleiomyoma / menopause / smooth muscle / uterus
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79. Sucandy I, Sharma D, Dalencourt G, Bertsch DJ: Gallbladder neurofibroma presenting as chronic epigastric pain - Case report and review of the literature. N Am J Med Sci; 2010 Oct;2(10):496-8
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  • CONTEXT: Benign nonepithelial neoplasms of the gallbladder are unusual.
  • In this study we report a case of gallbladder neurofibroma presenting as chronic epigastric pain in a young patient.
  • Physical examination, laboratory and radiologic workups were unremarkable for signs of biliary tract diseases.
  • Open conversion was necessitated because of the presence of a gallbladder mass preventing safe anatomic dissection.
  • CONCLUSIONS: Benign neoplasms such as gallbladder neurofibroma should be included in the differential diagnosis for chronic epigastric pain symptom in a young otherwise healthy patient with neurofibromatosis.

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  • (PMID = 22558554.001).
  • [ISSN] 1947-2714
  • [Journal-full-title] North American journal of medical sciences
  • [ISO-abbreviation] N Am J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3339114
  • [Keywords] NOTNLM ; Neurofibroma / benign tumors / gallbladder
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80. Velnar T, Bunc G: Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. Wien Klin Wochenschr; 2008;120(23-24):766-9
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  • [Title] Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report.
  • As far as we know, the presented case is the first report in the literature of iatrogenic seeding of a benign meningioma to the scalp following surgery.
  • A 37-year-old woman was admitted because of a relapsing meningioma in the frontal lobe.
  • At follow-up, three new masses were found: a bifrontal meningioma on the edge of the falx, a smaller one in the falx just under the saggital sinus and a small mass, believed to be ectopic, in the periosteum at the site of the previous craniotomy.
  • Histologically, the ectopic tumor was an atypical meningioma, similar to the one excised 10 years previously, with no relation to the other two intracranial masses.
  • Because of the histological similarity and the location in the old craniotomy, the ectopic tumor was believed to have developed from an implantation metastasis as a consequence of the first surgery.
  • The authors suggest that strict adherence to oncological principles should be applied in the case of benign neoplasms in order to prevent contamination of wounds with tumor cells and potential recurrence.
  • [MeSH-major] Craniotomy. Meningeal Neoplasms / surgery. Meningioma / secondary. Meningioma / surgery. Neoplasm Seeding. Neoplasms, Multiple Primary / surgery. Periosteum. Skull Neoplasms / secondary

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  • (PMID = 19122989.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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81. Harper L, Lavrand F, Le Bail B, Brun M, Ferron S, Oses P, Vergnes P: Glomus tumor of the mesocolon. J Pediatr Surg; 2005 Oct;40(10):e37-8
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  • [Title] Glomus tumor of the mesocolon.
  • Glomus tumors are rare distinctive benign neoplasms, which arise from modified smooth muscle cells of the normal glomus body and are most commonly located in the subungual region of the finger.
  • We report a case of glomus tumor of the mesocolon in a 10-year-old girl.
  • Histopathology showed it to be a glomus tumor of the mesocolon.
  • [MeSH-major] Glomus Tumor. Mesocolon. Peritoneal Neoplasms

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  • (PMID = 16226974.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Park EA, Cho JY, Lee MW, Kim SH, Seong CK, Kim SH: MR features of fluid-fluid levels in ovarian masses. Eur Radiol; 2007 Dec;17(12):3247-54
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  • In non-teratomas, we assessed whether SI of the FFLs of benign masses and malignant neoplasms differed using the chi(2) test.
  • FFLs were observed in 66 of 556 ovarian masses (11.9%) on MR images, fat-fluid levels were observed in 11 of 80 teratomas, and FFLs attributed to hemorrhage in 54 of 476 non-teratomas and one twisted teratoma.
  • Non-neoplastic cystic lesions were most common non-teratomas to contain FFLs (27/197, 13.7%), followed by malignant neoplasms (23/177, 13.0%).
  • Benign neoplasms rarely contained FFLs (4/102, 3.9%); those that did were commonly associated with complications such as torsion or inflammation.
  • A hypointense supernatant layer together with a hyperintense dependent layer on T1-weighted images (T1WIs) was significantly more common in malignant neoplasms than in benign masses (P < 0.0001).
  • FFLs occurred in various ovarian masses ranging from benign to malignant neoplasms on MR images.
  • In non-teratomas, a hypointense supernatant layer and a hyperintense dependent layer on T1WIs may favor a diagnosis of malignancy.
  • [MeSH-minor] Adolescent. Adult. Aged. Chi-Square Distribution. Child. Contrast Media. Diagnosis, Differential. Female. Gadolinium DTPA. Humans. Middle Aged. Retrospective Studies

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  • (PMID = 17639405.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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83. Kaspareit J, Friderichs-Gromoll S, Buse E, Habermann G: Spontaneous neoplasms observed in cynomolgus monkeys (Macaca fascicularis) during a 15-year period. Exp Toxicol Pathol; 2007 Nov;59(3-4):163-9
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  • [Title] Spontaneous neoplasms observed in cynomolgus monkeys (Macaca fascicularis) during a 15-year period.
  • A total of 33 tumors were observed during a time period of 15 years (1992-2006) in cynomolgus monkeys.
  • The great majority of neoplasms was benign (23 benign neoplasms versus 10 malignant tumors).
  • The age of tumor-bearing animals ranged between 2 years 2 months and 13 years 9 months.
  • Most of the tumors (22) in the cynomolgus monkeys were seen in endocrine organs (adrenal cortical adenoma, adrenal hemangioma, C-cell carcinoma, follicular adenoma), respiratory system (nasal cavity adenoma, pulmonary squamous cell carcinoma, bronchio-alveolar carcinoma, bronchiolar papilloma, chondromatous hamartoma) and female genital system (uterine polyp, uterine adenoma, uterine leiomyoma and teratoma of the ovary).
  • [MeSH-major] Macaca fascicularis. Monkey Diseases / pathology. Neoplasms / veterinary

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  • (PMID = 17869495.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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84. Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, Casanova M, Mattavelli F, Scaramellini G: Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer; 2006 Nov;47(6):806-10
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  • [Title] Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan.
  • BACKGROUND: Epithelial salivary gland tumors are very uncommon in pediatric age.
  • We report a series of 52 cases treated at the Istituto Nazionale Tumori of Milan, Italy, over a 30-year period.
  • These results are presented in conjunction with a literature review of salivary tumors with a view to providing an up-to-date overview of the clinical course, prognosis, and treatment options for this rare tumor.
  • PROCEDURE: Fifty-two cases of epithelial salivary tumors were reviewed and the clinical-pathological information concerning tumor characteristics, therapy, and follow-up were collected.
  • RESULTS: The major salivary glands were the main site of tumor occurrence (79% of cases arose in parotid glands); 37 patients had benign tumors (pleomorphic adenoma), 15 had malignant tumors (12 mucoepidermoid carcinoma, 9 low grade).
  • All the patients were treated by surgery; local relapses after parotidectomy were 4% and 25%, in benign and malignant tumors, respectively.
  • When tumor enucleation was performed, recurrences occurred in 50% of benign neoplasms.
  • At the time of the report, all patients with benign tumors were alive, 35(95%) without evidence of disease; only one patient with malignant tumor died of disease.
  • CONCLUSIONS: Epithelial salivary glands tumor in children had different characteristics compared with their adult counterpart with respect to the frequency of histotypes and site of occurrence, but their prognosis seems to be similar.
  • Parotidectomy (total or superficial) is the best choice for achieving good cure rates in both benign and malignant tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Carcinoma, Acinar Cell / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / surgery

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16425245.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Yancovitz M, Gonzalez ME, Votava HJ, Walters R, Kundu R, Shupack JL: Acquired smooth-muscle hamartoma. Dermatol Online J; 2009;15(8):12
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  • Cutaneous smooth-muscle hamartomas are uncommon benign neoplasms.
  • These lesions have been described as part of a spectrum of neoplasms that include Becker nevi since they share many clinical and histopathologic features.

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  • (PMID = 19891920.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. González-Moles MA, Mosqueda-Taylor A, Delgado-Rodríguez M, Martínez-Mata G, Gil-Montoya JA, Díaz-Franco MA, Bravo-Pérez JJ, M-González N: Analysis of p53 protein by PAb240, Ki-67 expression and human papillomavirus DNA detection in different types of odontogenic keratocyst. Anticancer Res; 2006 Jan-Feb;26(1A):175-81
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  • OBJECTIVE: To investigate the possible association between alterations in the p53 system and human papillomavirus (HPV) infection in the etiology of odontogenic keratocysts (OKCs) and to study proliferation and epithelial maturation patterns by topographic analysis of Ki-67 expression.
  • MATERIALS AND METHODS: Eighty-three OKC samples (29 cases associated with nevoid basal cell carcinoma syndrome, 29 solitary non-recurrent cases 20 solitary recurrent cases, and 5 chondroid keratocysts) were studied by immunohistochemistry to detect p53 protein (PAb 244) and Ki-67 (MIB-1) expression, and by PCR to detect HPV DNA.
  • OKCs show proliferation and genuine maturation behavior reminiscent of benign neoplasms with local destructive capacity.
  • [MeSH-major] DNA, Viral / analysis. Ki-67 Antigen / biosynthesis. Odontogenic Cysts / metabolism. Odontogenic Cysts / virology. Papillomaviridae / genetics. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 16475695.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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87. Braunschweig T, Kaserer K, Chung JY, Bilke S, Krizman D, Knezevic V, Hewitt SM: Proteomic expression profiling of thyroid neoplasms. Proteomics Clin Appl; 2007 Mar;1(3):264-71
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  • [Title] Proteomic expression profiling of thyroid neoplasms.
  • Thyroid cancer is the most common endocrine neoplasm with multiple histologic subtypes, each associated with different treatments and outcomes.
  • Differentiating benign neoplasms such as follicular adenomas from malignant entities such as follicular carcinomas and papillary carcinoma can be challenging.
  • To define the proteomic profile of different thyroid tumors, we screened an antibody array of 330 features against five thyroid neoplasms: follicular adenoma, follicular carcinoma, papillary carcinoma, anaplastic carcinoma, and medullary carcinoma as well as normal thyroid epithelium.
  • Eight candidate biomarkers; c-erbB-2, Stat5a, Annexin IV, IL-11, RARα, FGF7, Caspase 9, and phospho-c-myc were identified as differentially expressed on the antibody array, and validated with immunohistochemistry on tissue microarrays, with a total of 144 samples of the same variety of thyroid neoplasms.
  • Analysis revealed c-erbB-2, Annexin IV, and Stat5a have potential clinical utility to differentiate follicular adenoma, follicular carcinoma, and papillary carcinoma from each other.
  • By using an antibody array as a discovery platform and a tissue microarray as a first step in validation on a large number of specimens, we have identified new markers that have potential utility in the diagnosis of thyroid neoplasms.

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  • [Copyright] Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • (PMID = 21136677.001).
  • [ISSN] 1862-8346
  • [Journal-full-title] Proteomics. Clinical applications
  • [ISO-abbreviation] Proteomics Clin Appl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Carney JA: Hyalinizing trabecular tumors of the thyroid gland: quadruply described but not by the discoverer. Am J Surg Pathol; 2008 Apr;32(4):622-34
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  • [Title] Hyalinizing trabecular tumors of the thyroid gland: quadruply described but not by the discoverer.
  • Hyalinizing trabecular tumors of the thyroid have been described on 4 occasions, by Carney and colleagues in 1987, by Ward and coworkers in 1982, by Pierre Masson in 1922, and by Rahel Zipkin in 1905.
  • Unaware of the 3 earlier descriptions, Carney and colleagues described 11 circumscribed or encapsulated thyroid tumors with elongated and polygonal cells arranged in trabeculae that contained a hyaline material resembling amyloid.
  • The nuclei of the tumor cells had cytoplasmic invaginations and grooves similar to those of papillary carcinoma.
  • Carney and colleagues labeled the neoplasms hyalinizing trabecular adenomas because of their microscopic appearance, absence of invasion, and benign natural history.
  • Subsequently, the nuclear features of the tumor and the molecular genetic findings led to the introduction of equivocal designations for it, hyalinizing trabecular tumor and hyalinizing trabecular neoplasm, and later to its designation as a variant of papillary carcinoma.
  • Experience has shown that most circumscribed or encapsulated follicular thyroid tumors with intratrabecular hyalin and nuclear features of papillary carcinoma behave as benign neoplasms.
  • Hyalinizing trabecular carcinoma is a very rare tumor.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Papillary / pathology. Hyalin / metabolism. Terminology as Topic. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18367942.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Historical Article; Journal Article; Portraits
  • [Publication-country] United States
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89. Landi B, Palazzo L: The role of endosonography in submucosal tumours. Best Pract Res Clin Gastroenterol; 2009;23(5):679-701
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  • Submucosal tumours (SMTs) are relatively common findings in patients undergoing endoscopy, especially in upper gastrointestinal (GI) tract.
  • This term includes various non-neoplastic and neoplastic conditions.
  • In this review, the following issues will be addressed: the endosonographic features of SMT; the diagnostic accuracy of EUS; the ability of EUS to distinguish benign and malignant SMTs; the value of EUS-guided fine-needle aspiration (FNA); and the influence of EUS on clinical management.
  • [MeSH-major] Endoscopy, Gastrointestinal. Endosonography. Gastrointestinal Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Gastrointestinal Stromal Tumors / ultrasonography. Humans. Mucous Membrane / ultrasonography. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 19744633.001).
  • [ISSN] 1532-1916
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 33
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90. Hulsmann AR, de Bont N, den Hollander JC, Borgstein JA: Hamartomas of the oro- and nasopharyngeal cavity in infancy: two cases and a short review. Eur J Pediatr; 2009 Aug;168(8):999-1001
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  • [Title] Hamartomas of the oro- and nasopharyngeal cavity in infancy: two cases and a short review.
  • INTRODUCTION: Oro- and nasopharyngeal masses are rare in infancy and consist of developmental anomalies and, mostly benign, neoplasms.
  • CASE REPORT: We report two infants with a tumour in the ear-nose-throat region.
  • [MeSH-major] Dermoid Cyst / pathology. Esophageal Neoplasms / pathology. Hamartoma / pathology. Oropharyngeal Neoplasms / pathology. Otorhinolaryngologic Diseases / pathology

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  • [Cites] Am J Surg Pathol. 2007 Aug;31(8):1186-90 [17667541.001]
  • [Cites] Pediatr Surg Int. 2003 Nov;19(9-10):639-45 [14600772.001]
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  • (PMID = 18987884.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 77
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91. Mimatsu K, Oida T, Kawasaki A, Aramaki O, Kuboi Y, Katsura Y, Amano S: Preoperatively undetected solitary bile duct hamartoma (von Meyenburg complex) associated with esophageal carcinoma. Int J Clin Oncol; 2008 Aug;13(4):365-8
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  • Bile duct hamartomas, also known as von Meyenburg complexes, are benign neoplasms consisting of cystic dilatation of the bile duct surrounded by fibrous stroma.
  • We report a rare case in a 60-year-old man who presented with coexistent von Meyenburg complex and esophageal carcinoma.
  • Preoperative computed tomography did not reveal any liver tumors.
  • As von Meyenburg complexes are small cystic lesions located throughout the liver, and as they do not present characteristic imaging findings, their preoperative morphological diagnosis and differential diagnosis from liver metastasis is extremely difficult.
  • In conclusion, von Meyenburg complex should be considered in the differential diagnosis of intrahepatic cystic neoplasms.
  • [MeSH-major] Bile Duct Diseases / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / complications. Hamartoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Male. Middle Aged

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  • (PMID = 18704640.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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92. Ramana RK, Darki A, Havens M, Wojcik E, Brylka D, Singh MM, Leya F: Lipotamous cardiac disorders: two unsual cases and a review of the literature. J Invasive Cardiol; 2009 Apr;21(4):E65-9
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  • [Title] Lipotamous cardiac disorders: two unsual cases and a review of the literature.
  • Tumors involving the heart and surrounding cardiac structures may be benign or malignant and can be classified as primary versus secondary in etiology.
  • Primary cardiac tumors are rare lesions and the vast majority of these are benign neoplasms.
  • [MeSH-major] Cardiomyopathy, Hypertrophic / diagnosis. Heart Diseases / diagnosis. Heart Neoplasms / diagnosis. Lipomatosis / diagnosis

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  • (PMID = 19342764.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
  • [Number-of-references] 36
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93. Ang WM, Yates P, Robbins P, Wood D: Recurrent benign solitary intraosseous schwannoma of the tibia. Orthopedics; 2008 Feb;31(2):176
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  • [Title] Recurrent benign solitary intraosseous schwannoma of the tibia.
  • Schwannomas (neurilemmomas) are benign neoplasms composed of well-differentiated Schwann cells and are usually found in the soft tissues.
  • The occurrence of schwannomas in bone is rare, accounting for less than 0.2% of primary bone tumors.
  • We report the first case of a recurrent benign solitary intraosseous schwannoma of the tibia, and detail the clinical, radiological and histological findings.
  • [MeSH-major] Bone Neoplasms / radiography. Bone Neoplasms / surgery. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / surgery. Neurilemmoma / radiography. Neurilemmoma / surgery. Tibia / surgery

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  • (PMID = 19292192.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Biswas D, Marnane CN, Mal RK, Baldwin DL: The presenting features of middle ear facial nerve sheath tumors: a clinical review. Am J Otolaryngol; 2008 Jan-Feb;29(1):58-62
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  • [Title] The presenting features of middle ear facial nerve sheath tumors: a clinical review.
  • Facial nerve sheath tumors are the most common middle ear benign neoplasms.
  • Four facial nerve sheath tumors in the middle ear were diagnosed in our department over a 12-year period, and we described our experience in the management of these tumors.
  • A thorough review of the English literature on middle ear peripheral nerve sheath tumors has been conducted, and the findings of this review are presented and discussed.
  • We have paid particular attention to the presenting features of these tumors with the aim of enhancing diagnostic ability.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Ear, Middle / innervation. Facial Nerve Diseases / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Retrospective Studies. Tomography, X-Ray Computed / methods

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  • [CommentIn] Am J Otolaryngol. 2010 Jan-Feb;31(1):72; author reply 72 [19944908.001]
  • (PMID = 18061834.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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95. Farage MA, Miller KW, Berardesca E, Maibach HI: Neoplastic skin lesions in the elderly patient. Cutan Ocul Toxicol; 2008;27(3):213-29
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  • Benign neoplasms afflict virtually every individual over the age of 65, and more often than not afflicted individuals carry large numbers of growths.
  • Malignant neoplasms, which can create significant morbidity, are increasing in parallel to an increase in prevalence.
  • [MeSH-major] Carcinoma, Basal Cell. Carcinoma, Squamous Cell. Keratosis, Actinic. Skin Neoplasms / epidemiology

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  • (PMID = 18988090.001).
  • [ISSN] 1556-9535
  • [Journal-full-title] Cutaneous and ocular toxicology
  • [ISO-abbreviation] Cutan Ocul Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Dabholkar JP, Chhabria S, Mishra M, Chirmade S, Sikdar A: Benign laryngopharyngeal lesions: a case series. Indian J Otolaryngol Head Neck Surg; 2008 Mar;60(1):7-10
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  • [Title] Benign laryngopharyngeal lesions: a case series.
  • Benign neoplasms of the laryngopharynx are extremely rare.
  • While one was managed by conventional endoscopic route the other two required external approach.
  • All these cases highlights the need of a competent surgeon to treat benign laryngopharyngeal lesions.

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  • [Cites] Ann Otol Rhinol Laryngol. 2000 Mar;109(3):301-5 [10737315.001]
  • (PMID = 23120489.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450707
  • [Keywords] NOTNLM ; Laryngofissure / Microlaryngoscopy / Pharyngotomy / Schwannoma
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97. Wanke I, Jäckel MC, Goericke S, Panagiotopoulos V, Dietrich U, Forsting M: Percutaneous embolization of carotid paragangliomas using solely Onyx. AJNR Am J Neuroradiol; 2009 Sep;30(8):1594-7
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  • BACKGROUND AND PURPOSE: Paragangliomas are highly vascularized usually benign neoplasms arising from nerve tissue.
  • Our purpose was to evaluate angiographic and clinical outcome using Onyx for percutaneous glomus tumor embolization.
  • CONCLUSIONS: Further documentation is necessary to prove the higher grade of devascularization of paragangliomas with Onyx compared with other embolic material and the associated potential to facilitate surgery.
  • Nevertheless, Onyx seems to be safe when used percutaneously due to its lavalike pattern flow and its controllable properties, allowing slow tumor bed penetration.
  • [MeSH-major] Carotid Body Tumor / radiography. Carotid Body Tumor / therapy. Cerebral Angiography. Dimethyl Sulfoxide / therapeutic use. Embolization, Therapeutic / methods. Polyvinyls / therapeutic use

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  • (PMID = 19369617.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemostatics; 0 / Onyx copolymer; 0 / Polyvinyls; YOW8V9698H / Dimethyl Sulfoxide
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98. Dias Pereira P, Lopes CC, Matos AJ, Santos M, Gärtner F, Medeiros R, Lopes C: COX-2 expression in canine normal and neoplastic mammary gland. J Comp Pathol; 2009 May;140(4):247-53
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  • COX-2 expression was examined immunohistochemically in samples of normal canine mammary tissue (n=22) and benign (n=36) and malignant (n=45) mammary tumours including metastases (n=12).
  • By contrast, in neoplastic lesions and in adjacent non-neoplastic mammary tissue COX-2 was expressed in the cytoplasm of epithelial cells, suggesting that internalization of the molecule is associated with oncogenesis.
  • Marked expression of COX-2 was observed in 8.3% of benign neoplasms and in 42.2% of malignant neoplasms, mainly in poorly differentiated areas.
  • The majority of metastatic lesions (58.3%) exhibited strong COX-2 labelling and in almost all cases (83.3%) the labelling intensity was similar or stronger to that of the primary neoplasm.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Dog Diseases / enzymology. Mammary Glands, Animal / enzymology. Mammary Neoplasms, Animal / enzymology. Neoplasms / enzymology. Neoplasms / veterinary
  • [MeSH-minor] Animals. Dogs. Female. Immunohistochemistry / veterinary. Neoplasm Metastasis / pathology

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  • (PMID = 19203768.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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99. Keenan S, Bui-Mansfield LT: Musculoskeletal lesions with fluid-fluid level: a pictorial essay. J Comput Assist Tomogr; 2006 May-Jun;30(3):517-24
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  • The presence of fluid-fluid levels within a musculoskeletal lesion is an important finding, which can significantly aid in the differential diagnosis.
  • This finding can be observed in a wide variety of lesions: osseous and soft tissue masses, neoplastic or nonneoplastic lesions, malignant or benign neoplasms, and primary or metastatic malignancies.
  • When a fluid-fluid level is detected, in conjunction with clinical history, the differential diagnosis for a lesion can often be limited to a few choices.
  • We will review both osseous and soft tissue lesions, focusing on their imaging characteristics and other important findings.
  • [MeSH-major] Body Fluids. Magnetic Resonance Imaging. Musculoskeletal Diseases / diagnosis
  • [MeSH-minor] Bone Cysts / diagnosis. Bone Cysts, Aneurysmal / diagnosis. Bone Neoplasms / diagnosis. Chondroblastoma / diagnosis. Diagnosis, Differential. Fibrous Dysplasia of Bone / diagnosis. Humans. Lipoma / diagnosis. Osteosarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16778633.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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100. Do TV, Kubba LA, Antenos M, Rademaker AW, Sturgis CD, Woodruff TK: The role of activin A and Akt/GSK signaling in ovarian tumor biology. Endocrinology; 2008 Aug;149(8):3809-16
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  • [Title] The role of activin A and Akt/GSK signaling in ovarian tumor biology.
  • We hypothesize that activin A plays a role in ovarian tumor biology, and analyzed activin-mediated pro-oncogenic signaling in vitro and the expression of activin signaling pathway molecules in vivo.
  • To validate in vitro observations, immunostaining of the betaA-subunit of activin A and phospho-GSKalpha/beta (Ser9/21) was performed, and the correlation between immunoreactivity levels of these markers and survival was evaluated in benign serous cystadenoma, borderline tumor, and cystadenocarcinoma microarrays.
  • Analysis of tissue microarrays revealed that betaA expression in epithelia did not correlate with survival or malignancy, but expression was elevated in stromal cells from carcinomas when compared with benign tumors.
  • Phospho-GSKalpha/beta (Ser9/21) staining was more intense in mitotically active carcinoma cells and exhibited a polarized localization in benign neoplasms that was absent in carcinomas.

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  • (PMID = 18450971.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD044464; United States / NICHD NIH HHS / HD / HD044464
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / activin A; 104625-48-1 / Activins; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.26 / Glycogen Synthase Kinase 3
  • [Other-IDs] NLM/ PMC2488253
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