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1. Vaysse C, Delsol M, Carfagna L, Bouali O, Combelles S, Lemasson F, Le Mandat A, Castex MP, Pasquet M, Moscovici J, Guitard J, Pienkowski C, Rubie H, Galinier P, Vaysse P: Ovarian germ cell tumors in children. Management, survival and ovarian prognosis. A report of 75 cases. J Pediatr Surg; 2010 Jul;45(7):1484-90
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  • [Title] Ovarian germ cell tumors in children. Management, survival and ovarian prognosis. A report of 75 cases.
  • BACKGROUND/PURPOSE: The aims of this study were to evaluate survival and ovarian prognosis in patients treated for ovarian germ cell tumor (OGCT) and to propose a decision-making protocol.
  • Tumor characteristics were assessed by tumor markers, imaging, and pathology.
  • Tumors were benign in 58 cases and malignant in 17 cases.
  • The average of the largest diameter of benign OGCT was significantly lower than that of malignant OGCT (76.5 +/- 49 mm versus 169 +/- 54 mm, P < .0001).
  • Ovarian-sparing tumorectomy was carried out in 27 benign OGCT; 23 (85%) preserved ovaries were follicular.
  • CONCLUSIONS: In our series, both benign and malignant OGCTs have a good prognosis.
  • A 75-mm cutoff size is proposed as an important criterion to preoperatively differentiate between benign and malignant tumors.
  • In benign OGCT, ovarian-sparing tumorectomy leads to preserve ovaries in approximately 85% of cases, and in malignant OGCT, high survival rate has been obtained.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adolescent. Biomarkers, Tumor. Child. Child, Preschool. Female. France. Humans. Infant. Ovariectomy. Prognosis. Retrospective Studies

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20638529.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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2. Azurmendi Arín I, Llarena Ibarguren R, Rodríguez JG, Olano Grasa I, Cantón Aller E, Pertusa Peña C: [Sertoli cell malignant tumor]. Arch Esp Urol; 2008 Sep;61(7):834-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sertoli cell malignant tumor].
  • [Transliterated title] Tumor de células de Sertoli maligno.
  • OBJECTIVE: We report a new case of Sertoli cell testicular tumor with malignant characteristics.
  • METHODS: 77 year-old male patient, suffering a general wasting syndrome presenting with a left solid testicular mass with the diagnosis of malignant Sertoli cell tumor after orchyectomy, without local, regional or distant dissemination, and a benign outcome after 18 months of follow-up.
  • RESULTS: Sertoli cell tumor or androblastoma is classified as non-germ cell tumor derived from the stroma of the sexual cords.
  • There are three types depending on its cellular composition: calcified big cell, sclerotic cell, and the most frequent of all, the classic type.
  • CONCLUSIONS: Being the Sertoli cell testicular tumor rare, its malignant type is even rarer, accounting for not more than 10% of all.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 18972923.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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3. Gorosito M, Pancera B, Sarancone S, Nocito AL: Gonadoblastoma: an unusual ovarian tumor. Ann Diagn Pathol; 2010 Aug;14(4):247-50
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  • [Title] Gonadoblastoma: an unusual ovarian tumor.
  • Gonadoblastomas are unusual benign neoplasias that frequently appear in the dysgenetic gonads of women with chromosome Y anomaly.
  • In all the cases, the histologic examination showed germ cell proliferation and sex cords derivatives frequently surrounding small round deposits containing amorphous hyaline material resembling Call-Exner bodies.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20637428.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Oltmann SC, Garcia N, Barber R, Huang R, Hicks B, Fischer A: Can we preoperatively risk stratify ovarian masses for malignancy? J Pediatr Surg; 2010 Jan;45(1):130-4
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  • RESULTS: A total of 424 patients were identified, with a mean age 12.5 years (range, 1 day to 19 years), without an age disparity between benign (12.54 years, 89%) and malignant (11.8 years, 11%) cases.
  • Imaging of benign neoplasms had a mean size of 8 cm (range, 0.9-36 cm) compared with malignancies at 17.3 cm (6.2-50 cm, P < .001).
  • The malignancies (n = 46) included germ cell (50%, n = 23), stromal (28%, n = 13), epithelial (17%, n = 8), and other (4%, n = 2).
  • Tumor markers obtained in 71% of malignancies were elevated in only 54%, whereas 6.5% of those sent in benign cases were similarly elevated.
  • Tumor markers, positive or negative, were not conclusive in all cases but useful for postoperative surveillance.
  • [MeSH-minor] Abdominal Pain / diagnosis. Age Factors. Biomarkers, Tumor / blood. CA-125 Antigen / blood. Carcinoembryonic Antigen / blood. Child. Child, Preschool. Confidence Intervals. Diagnosis, Differential. Female. Humans. Infant. Neoplasm Staging. Neoplasms / blood. Neoplasms / diagnosis. Neoplasms / surgery. Ovary / pathology. Ovary / surgery. Prognosis. Puberty, Precocious / diagnosis. Risk Assessment

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20105592.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen
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5. Segal NH, Blachere NE, Shiu HY, Leejee S, Antonescu CR, Lewis JJ, Wolchok JD, Houghton AN: Antigens recognized by autologous antibodies of patients with soft tissue sarcoma. Cancer Immun; 2005 Mar 4;5:4
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  • In order to identify tumor antigens in soft tissue sarcoma (STS), sera from four patients with malignant fibrous histiocytoma (MFH), gastrointestinal stromal tumor (GIST), pleomorphic liposarcoma, and dedifferentiated liposarcoma were screened against cDNA libraries derived from autologous tumor.
  • Using oligonucleotide microarray technology, most genes were variably expressed across a panel of 16 benign specimens and 41 STSs of different histologies.
  • DLG7, however, showed restricted expression in testes and cancer, similarly to known germ cell cancer-testis antigens (or germ cell antigens, GCAs).
  • [MeSH-major] Antibodies, Neoplasm / immunology. Antigens, Neoplasm / immunology. Sarcoma / immunology

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  • (PMID = 15745419.001).
  • [ISSN] 1424-9634
  • [Journal-full-title] Cancer immunity
  • [ISO-abbreviation] Cancer Immun.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Immunoglobulin G
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6. Carmignani L, Morabito A, Gadda F, Bozzini G, Rocco F, Colpi GM: Prognostic parameters in adult impalpable ultrasonographic lesions of the testicle. J Urol; 2005 Sep;174(3):1035-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically 15 of the lesions were Leydig cell tumors (31%), 12 (25%) seminomas, 7 (14.5%) nonseminomatous germ cell tumors, 2 (4.5%) Sertoli cell tumors, 12 (25%) benign forms (fibrosis, infarct, lipoma, mesothelial hyperplasia, adenomatoid tumor).
  • Dimension was particularly related to germ cell tumors (for dimensions between 16 and 32 mm relative risk ratio [RRR] = 13.97, p=0.0449).
  • In particular an interesting correlation was found between the dimensions of the lesion and the malignant pathology and between Leydig cell tumor and infertility.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Follow-Up Studies. Humans. Infertility, Male / mortality. Infertility, Male / pathology. Infertility, Male / ultrasonography. Logistic Models. Male. Mathematical Computing. Middle Aged. Multivariate Analysis. Neoplasms, Germ Cell and Embryonal / mortality. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / ultrasonography. Prognosis. Retrospective Studies. Risk. Statistics as Topic. Survival Rate. Task Performance and Analysis

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  • (PMID = 16094042.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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7. Gwin K, Mariño-Enríquez A, Martel M, Reyes-Múgica M: Sclerosing stromal tumor: an important differential diagnosis of ovarian neoplasms in childhood and adolescence. Pediatr Dev Pathol; 2009 Sep-Oct;12(5):366-70
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  • [Title] Sclerosing stromal tumor: an important differential diagnosis of ovarian neoplasms in childhood and adolescence.
  • Sclerosing stromal tumors are an uncommon type of benign ovarian sex cord-stromal tumor.
  • Although the usual age of presentation is in the 2nd and 3rd decades, sclerosing stromal tumor can occur in adolescence or premenarchal girls.
  • Imaging studies frequently reveal solid or complex cystic adnexal masses with marked vascularity raising concern for germ cell tumors and, especially in the absence of elevated tumor markers, surface epithelial neoplasms.
  • The differential diagnosis of a benign sclerosing stromal tumor is seldom entertained.

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  • (PMID = 19071970.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Trousse D, Avaro JP: [Mediastinal tumors: introduction]. Rev Pneumol Clin; 2010 Feb;66(1):3-16
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  • Mediastinal masses represent a group of heterogeneous histological type cell.
  • A definite diagnosis is essential leading to an adequate prompt therapeutic strategy when either benign disease or aggressive malignant tumor is conceivable.
  • However the specific diagnosis could be complex and requires histological confirmation by an experienced pathologist after examination of large biopsies of the tumor.
  • [MeSH-minor] Adult. Diagnosis, Differential. Goiter / diagnosis. Goiter / pathology. Goiter / surgery. Humans. Lymph Node Excision. Lymphatic Metastasis / pathology. Lymphoma / diagnosis. Lymphoma / pathology. Lymphoma / surgery. Mediastinoscopy. Mediastinum / pathology. Mediastinum / surgery. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Thoracotomy. Thymoma / diagnosis. Thymoma / pathology. Thymoma / surgery. Thymus Neoplasms / diagnosis. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery. Tomography, X-Ray Computed. Video Recording. Young Adult

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20207291.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 40
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9. Stremmel C, Passlick B: [Surgery of mediastinal tumors]. Chirurg; 2008 Jan;79(1):9-10, 12-7
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  • Thymomas, lymphomas, and germ cell tumors are the most frequent lesions of the anterior mediastinum, whereas endodermal (bronchogenic) cysts and lymphomas are the most frequent lesions of the middle mediastinum.
  • Depending on tumor location, mediastinoscopy, mediastinotomy, and thoracoscopy are the preferred diagnostic methods.
  • The importance of surgical treatment of germ cell tumors is determined by a negative concentration of beta-HCG and alpha-fetoprotein and in cases of residual tumor after chemotherapy.
  • Ninety-eight percent of neurogenic tumors in adults are benign and usually resected via thoracoscopy or thoracotomy, depending on location and size.
  • [MeSH-major] Lymphoma / surgery. Mediastinal Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / surgery. Thymoma / surgery. Thymus Neoplasms / surgery
  • [MeSH-minor] Adult. Age Factors. Child. Female. Humans. Incidence. Male. Mediastinoscopy. Mediastinum / pathology. Neoplasm Staging. Prognosis. Radiography. Thoracoscopy. Thoracotomy

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  • [Cites] Ann Thorac Surg. 1991 Jul;52(1):6-13 [2069465.001]
  • [Cites] J Thorac Cardiovasc Surg. 1996 Aug;112(2):376-84 [8751506.001]
  • [Cites] J Thorac Cardiovasc Surg. 1983 Nov;86(5):727-31 [6632945.001]
  • [Cites] Chest. 1991 Feb;99(2):472-9 [1846573.001]
  • [Cites] Ann Thorac Surg. 1966 Jul;2(4):532-9 [5934068.001]
  • [Cites] J Pediatr Surg. 1986 Jun;21(6):548-51 [2425069.001]
  • [Cites] Cancer. 1981 Jan 15;47(2):373-81 [7459826.001]
  • [Cites] Ann Thorac Surg. 2003 Sep;76(3):878-84; discussion 884-5 [12963221.001]
  • [Cites] Ann Thorac Surg. 2002 Aug;74(2):615-23 [12173869.001]
  • [Cites] Ann Thorac Surg. 1986 Sep;42(3):338-45 [3530162.001]
  • [Cites] Ann Surg. 1948 Mar;127(3):476-502 [17859095.001]
  • [Cites] Ann Thorac Surg. 1991 Jan;51(1):152-6 [1985561.001]
  • [Cites] Ann Thorac Surg. 1987 Sep;44(3):229-37 [2820323.001]
  • [Cites] Int J Cancer. 2003 Jul 1;105(4):546-51 [12712448.001]
  • [Cites] Ann Thorac Surg. 2001 Jul;72 (1):208-11 [11465181.001]
  • [Cites] J Clin Oncol. 2002 Apr 1;20(7):1864-73 [11919246.001]
  • [Cites] Surg Today. 2005;35(10):805-11 [16175459.001]
  • [Cites] J Surg Oncol. 1992 May;50(1):43-6 [1573893.001]
  • [Cites] J Thorac Cardiovasc Surg. 2003 Feb;125(2):434-6 [12579125.001]
  • [Cites] Am J Surg Pathol. 2001 Jan;25(1):103-10 [11145244.001]
  • [Cites] Ann Thorac Surg. 2003 Dec;76(6):1859-64; discussion 1864-5 [14667600.001]
  • [Cites] Virchows Arch A Pathol Anat Histol. 1979 Jul 27;383(1):43-57 [157612.001]
  • [Cites] Cancer. 1997 Aug 15;80(4):681-90 [9264351.001]
  • [Cites] Ann Thorac Surg. 1995 Oct;60(4):943-6 [7574999.001]
  • [Cites] Thorax. 1978 Jun;33(3):359-67 [210531.001]
  • [Cites] Cancer. 1992 Jun 1;69(11):2755-60 [1373989.001]
  • [Cites] Ann Thorac Surg. 1995 Oct;60(4):908-13; discussion 914 [7574993.001]
  • [Cites] Ann Thorac Surg. 2004 May;77(5):1860-9 [15111216.001]
  • [Cites] Ann Surg. 1999 Oct;230(4):562-72; discussion 572-4 [10522726.001]
  • (PMID = 18058077.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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10. Kim E, Bae TS, Kwon Y, Kim TH, Chung KW, Kim SW, Ro J, Lee ES: Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. J Korean Med Sci; 2007 Jun;22(3):568-71
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  • [Title] Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report.
  • Teratomas comprise the most common extragonadal germ cell tumors in childhood.
  • Most teratomas involving the thyroid are benign and occur in children.
  • This is the first case, to our knowledge, of malignant thyroid teratoma with a exuberant primitive neuroectodermal tumor component in Korea.
  • [MeSH-minor] Adult. Female. Head and Neck Neoplasms / pathology. Humans. Neoplasm Metastasis. Positron-Emission Tomography / methods. Thyroid Diseases / diagnosis. Thyroidectomy. Tomography, X-Ray Computed

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  • [Cites] Cancer. 2000 Mar 1;88(5):1149-58 [10699906.001]
  • [Cites] Am J Otolaryngol. 2000 Mar-Apr;21(2):112-5 [10758996.001]
  • [Cites] Acta Cytol. 2000 May-Jun;44(3):375-9 [10833994.001]
  • [Cites] Ann Diagn Pathol. 2001 Oct;5(5):285-92 [11598856.001]
  • [Cites] N Engl J Med. 2003 Feb 20;348(8):694-701 [12594313.001]
  • [Cites] Thyroid. 2003 Apr;13(4):401-4 [12804109.001]
  • [Cites] Ann Oncol. 1998 Sep;9(9):1015-22 [9818077.001]
  • [Cites] J Clin Oncol. 1995 Nov;13(11):2796-804 [7595741.001]
  • [Cites] Am J Surg Pathol. 1997 Aug;21(8):896-904 [9255252.001]
  • [Cites] Am J Clin Oncol. 1998 Apr;21(2):212-4 [9537215.001]
  • [Cites] Ann Hematol. 1998 May;76(5):183-8 [9671130.001]
  • [Cites] Head Neck. 1998 Oct;20(7):649-53 [9744468.001]
  • [Cites] Bull Cancer. 1995;82 Suppl 1:56s-60s [7542945.001]
  • (PMID = 17596674.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2693658
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11. Lemeta S, Salmenkivi K, Pylkkänen L, Sainio M, Saarikoski ST, Arola J, Heikkilä P, Haglund C, Husgafvel-Pursiainen K, Böhling T: Frequent loss of heterozygosity at 6q in pheochromocytoma. Hum Pathol; 2006 Jun;37(6):749-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most PCCs are sporadic, but they also occur in inherited tumor syndromes, including von Hippel-Lindau disease.
  • Mutations of those genes that harbor germ-line mutations in familial cases cover only 10% to 15% of somatic mutations in sporadic PCCs.
  • We therefore investigated in detail 18 PCCs using 22 microsatellite markers spanning 6q to search for the presence of allele deletions and identify specific regions likely to contain tumor suppressor genes involved in PCC.
  • Moreover, we sought to compare PCC with capillary hemangioblastoma, another von Hippel-Lindau disease-associated tumor that we previously found to harbor frequent loss of heterozygosity (LOH) at 6q.
  • Loss of heterozygosity at 6q was observed in 6 benign (6/9; 67%) and 7 borderline (7/9; 78%) tumors.
  • Similar to our findings for capillary hemangioblastomas, our data for the first time suggest that one or several tumor suppressor genes located at 6q, particularly at 6q23-24, may play a role in the tumorigenesis of PCCs.
  • [MeSH-major] Allelic Imbalance. Cell Cycle Proteins / genetics. Chromosomes, Human, Pair 6. Loss of Heterozygosity. Pheochromocytoma / genetics. Transcription Factors / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Aged. Alleles. DNA, Neoplasm / analysis. Female. Gene Deletion. Genetic Markers. Hemangioblastoma / genetics. Hemangioblastoma / pathology. Humans. Male. Microsatellite Repeats. Middle Aged. Tumor Burden

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  • (PMID = 16733217.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA, Neoplasm; 0 / Genetic Markers; 0 / PLAGL1 protein, human; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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12. Miller JS, Lee TK, Epstein JI, Ulbright TM: The utility of microscopic findings and immunohistochemistry in the classification of necrotic testicular tumors: a study of 11 cases. Am J Surg Pathol; 2009 Sep;33(9):1293-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The submitting pathologists favored benign processes in 4 cases, Leydig cell tumor in 1, and lymphoma in 1.
  • Mean tumor size was 19 mm (range 7-53).
  • The combination of histologic features, immunostains and, in 1 case, serum AFP permitted classification of 8 tumors (4 seminomas, 3 embryonal carcinomas, 1 yolk sac tumor).
  • OCT4 stained 1 unclassifiable tumor, which lacked other specific markers.
  • We did not find placental alkaline phosphatase, AFP, and S100 stains useful, although S100 did highlight tumor "ghost" cells in 1 case.
  • Other features in most cases included intratubular germ cell neoplasia (6/11), tubular atrophy/hyalinization (10/11), tumor "ghost" cells (10/11), scar (9/11), and inflammation (10/11).
  • Of the 5 patients with available follow-up, 3 were free of disease at 1, 5, and 8 years after orchiectomy (2 necrotic seminomas and 1 germ cell tumor, unclassified).
  • One patient with yolk sac tumor (age 63 y) developed widespread metastases after 15 months and died of disease.
  • [MeSH-major] Carcinoma, Embryonal / classification. Endodermal Sinus Tumor / classification. Seminoma / classification. Testicular Neoplasms / classification
  • [MeSH-minor] Adolescent. Adult. Antigens, CD30 / analysis. Biomarkers, Tumor / analysis. Disease-Free Survival. Humans. Immunohistochemistry / methods. Keratins / analysis. Male. Middle Aged. Necrosis. Octamer Transcription Factor-3 / analysis. Orchiectomy. Proto-Oncogene Proteins c-kit / analysis. Young Adult. alpha-Fetoproteins / analysis

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  • (PMID = 19461507.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Biomarkers, Tumor; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / alpha-Fetoproteins; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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13. Gonzalez M, Krueger T, Schaefer SC, Ris HB, Perentes JY: Asymptomatic intrapericardial mature teratoma. Ann Thorac Surg; 2010 Jun;89(6):e46-7
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  • Benign mature teratomas are the most common type of germ cell tumors that arise in the anterior mediastinum.
  • Intrapericardial teratomas are a rare manifestation of this tumor type, which are generally diagnosed during infancy because of the heart compression symptoms they produce.

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20494011.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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14. Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF 3rd, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR Jr, Linehan WM, Schmidt LS, Zbar B: Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A; 2006 Oct 17;103(42):15552-7
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  • Birt-Hogg-Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(FLCN) gene, which encodes a tumor-suppressor protein, folliculin (FLCN), with unknown function.
  • The tumor-suppressor proteins encoded by genes responsible for several other hamartoma syndromes, LKB1, TSC1/2, and PTEN, have been shown to be involved in the mammalian target of rapamycin (mTOR) signaling pathway.


15. Sajadi KP, Dalton RR, Brown JA: Sex cord-gonadal stromal tumor of the rete testis. Adv Urol; 2009;:624173
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  • [Title] Sex cord-gonadal stromal tumor of the rete testis.
  • The radical orchiectomy specimen contained an undifferentiated spindled sex cord-stromal tumor arising in the rete testis.
  • Testicular sex cord-stromal tumors are far less common than germ cell neoplasms and are usually benign.
  • This undifferentiated sex cord-stromal tumor, occurring in a previously unreported location, is an example of an unusual lesion mimicking an intratesticular malignant neoplasm.

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  • [Cites] Semin Diagn Pathol. 2000 Nov;17(4):258-69 [11202544.001]
  • [Cites] Radiographics. 2002 Jan-Feb;22(1):189-216 [11796908.001]
  • [Cites] Semin Diagn Pathol. 2000 Nov;17(4):270-93 [11202545.001]
  • [Cites] Virchows Arch. 2004 Jun;444(6):567-71 [15088145.001]
  • [Cites] Mod Pathol. 1997 Jul;10(7):693-700 [9237180.001]
  • [Cites] Pathol Annu. 1990;25 Pt 2:51-108 [2202966.001]
  • [Cites] Mod Pathol. 2005 Feb;18 Suppl 2:S131-45 [15502808.001]
  • (PMID = 19125206.001).
  • [ISSN] 1687-6369
  • [Journal-full-title] Advances in urology
  • [ISO-abbreviation] Adv Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2612754
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16. Leseur J, Trivin F, Dupont-Bière E, Boucher E, Kerbrat P, Raoul JL: [Hemoperitoneum secondary to spontaneous rupture of metastatic liver of a testicular germ cell tumor]. Gastroenterol Clin Biol; 2007 Dec;31(12):1150-2
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  • [Title] [Hemoperitoneum secondary to spontaneous rupture of metastatic liver of a testicular germ cell tumor].
  • We report a case of hemoperitoneum secondary to a spontaneous rupture of liver metastases of a testicular germ cell cancer.
  • In clinical practice, some aetiologies must be considered in case of spontaneous hemoperitoneum, mainly rupture of liver tumors: hepatocellular carcinoma or unfrequently benign tumors; the rupture of a metastase is very uncommon.

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  • (PMID = 18176377.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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17. Mhawech-Fauceglia P, Herrmann FR, Bshara W, Odunsi K, Terracciano L, Sauter G, Cheney RT, Groth J, Penetrante R, Mhawech-Fauceglia P: Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody. J Clin Pathol; 2007 Jun;60(6):694-700
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  • [Title] Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody.
  • However, it is also expressed in subsets of lymphoblastic lymphoma, Merkel cell carcinoma (MCC) and desmoplastic small round cell tumour (DSRCT).
  • AIM: To determine expression of FLI-1 in various benign and malignant neoplasms, by immunohistochemical analysis on 4323 tumours using multiple tumour microarrays, as well as on whole sections.
  • RESULTS: FLI-1 was expressed in 46/62 EWS/PNETs, 2/3 olfactory neuroblastomas, 7/102 small cell carcinomas of the lung, 10/34 MCCs, 1/14 rhabdomyosarcoma, 19/132 non-Hodgkin's lymphomas, 2/3 DSRCTs, and in 53/74 benign and malignant vascular tumours.
  • In addition, 27/508 squamous cell carcinomas, 19/837 adenocarcinomas, 10/400 urothelial bladder cancers, 1/40 basal cell carcinomas, 3/29 liposarcomas, 1/40 glioblastoma multiforme and 9/29 medullar carcinomas of the breast expressed FLI-1.
  • Finally, the sensitivity and specificity of FLI-1 to distinguish EWS/PNET from other small round cell tumours (SRCTs) were 74.2% and 91.6%, respectively.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms / metabolism. Proto-Oncogene Protein c-fli-1 / metabolism
  • [MeSH-minor] Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / metabolism. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / metabolism. Neuroectodermal Tumors, Primitive / diagnosis. Neuroectodermal Tumors, Primitive / metabolism. Protein Array Analysis / methods. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / metabolism. Sensitivity and Specificity

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  • [Cites] Am J Surg Pathol. 2001 Aug;25(8):1061-6 [11474291.001]
  • [Cites] Am J Surg Pathol. 2000 Dec;24(12):1657-62 [11117787.001]
  • [Cites] Oncogene. 2001 Sep 10;20(40):5747-54 [11607824.001]
  • [Cites] Am J Surg Pathol. 2002 Mar;26(3):320-7 [11859203.001]
  • [Cites] Hum Pathol. 2003 Oct;34(10):994-1000 [14608532.001]
  • [Cites] Hum Pathol. 2004 Jan;35(1):122-8 [14745734.001]
  • [Cites] Mod Pathol. 2004 May;17(5):547-52 [15001993.001]
  • [Cites] Appl Immunohistochem Mol Morphol. 2004 Jun;12(2):160-5 [15354743.001]
  • [Cites] Am J Clin Pathol. 2004 Nov;122(5):721-7 [15491968.001]
  • [Cites] Nat Med. 1998 Jul;4(7):844-7 [9662379.001]
  • [Cites] Int J Dev Biol. 1998 May;42(4):561-72 [9694627.001]
  • [Cites] Histopathology. 2005 Jun;46(6):622-34 [15910593.001]
  • [Cites] Am J Surg Pathol. 2005 Aug;29(8):1025-33 [16006796.001]
  • [Cites] Am J Surg Pathol. 2005 Sep;29(9):1184-93 [16096408.001]
  • [Cites] Int J Gynecol Pathol. 2006 Apr;25(2):151-4 [16633064.001]
  • [Cites] Semin Diagn Pathol. 2000 Aug;17(3):216-24 [10968707.001]
  • [Cites] Appl Immunohistochem Mol Morphol. 2001 Sep;9(3):255-60 [11556754.001]
  • (PMID = 16917000.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Protein c-fli-1
  • [Other-IDs] NLM/ PMC1955051
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18. Gabeau-Lacet D, Grant E, Stemmer-Rachamimov A, Yock T, Tarbell NJ: Sellar abnormalities in female first-degree relatives. Clin Neurol Neurosurg; 2008 Feb;110(2):202-6
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  • Each of these cases was diagnosed and managed differently, illustrating the relative importance of radiographic imaging, tumor markers and histopathologic examination in the diagnosis and treatment of intracranial disease.
  • One daughter was treated presumptively for germinoma based on characteristic radiographic studies and slightly elevated tumor marker.
  • The other daughter's lesion exhibited radiographic characteristics concerning for pituitary macroadenoma but with slightly elevated germ cell tumor marker, raising the suspicion for germinoma.
  • Biopsy of the intrasellar mass revealed only proteinaceous material and normal anterior pituitary, consistent with cyst content without evidence of neoplasm.
  • At least two of the patients had benign cysts.

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  • (PMID = 18035480.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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19. Nistal M, García-Cabezas MA, Castello MC, De Miguel MP, Regadera J: Age-related epididymis-like intratesticular structures: benign lesions of Wolffian origin that can be misdiagnosed as testicular tumors. J Androl; 2006 Jan-Feb;27(1):79-85
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  • [Title] Age-related epididymis-like intratesticular structures: benign lesions of Wolffian origin that can be misdiagnosed as testicular tumors.
  • The ELITSs are distinct from atrophic seminiferous tubules with a Sertoli cell-only pattern and from the benign glandular teratomatous component of an involution of a malignant testicular germ cell tumor, the so-called burn-out germ cell tumor.

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  • (PMID = 16400082.001).
  • [ISSN] 0196-3635
  • [Journal-full-title] Journal of andrology
  • [ISO-abbreviation] J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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20. Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X: Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery. Hum Gene Ther; 2005 Dec;16(12):1367-76
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  • [Title] Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
  • Benign hamartomas develop in multiple organs, believed to be caused by somatic mutation in addition to germ line mutation to cause loss of both alleles of either the TSC1 or TSC2 tumor suppressor gene, with resultant dysregulated growth due to loss of hamartin or tuberin function, respectively.
  • MRI detected 100% of the renal lesions (cystadenomas, renal cell carcinomas) and 75% of the hepatic lesions (hemangiosarcomas), later identified by histology.
  • Cell-mediated gene delivery was evaluated by immunohistochemical analysis of renal, hepatic, and lung lesions after intravenous delivery of MS1 mouse endothelial cells, transduced to express an enhanced form of green fluorescent protein (EGFP).
  • [MeSH-major] Gene Transfer Techniques. Genetic Therapy / methods. Tuberous Sclerosis / pathology. Tuberous Sclerosis / therapy. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Animals. Brain / pathology. Cell Line. Disease Models, Animal. Endothelial Cells. Genes, Tumor Suppressor. Green Fluorescent Proteins / genetics. Green Fluorescent Proteins / metabolism. Kidney Neoplasms / pathology. Lung / pathology. Magnetic Resonance Imaging. Mice. Mice, Knockout. Transduction, Genetic. Transgenes

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  • (PMID = 16390268.001).
  • [ISSN] 1043-0342
  • [Journal-full-title] Human gene therapy
  • [ISO-abbreviation] Hum. Gene Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA69246; United States / NINDS NIH HHS / NS / NS24279; United States / NCI NIH HHS / CA / P50 CA86355; United States / NCI NIH HHS / CA / R24 CA92782
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 147336-22-9 / Green Fluorescent Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein
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21. Liddle AD, Anderson DR, Mishra PK: Intrapericardial teratoma presenting in fetal life: intrauterine diagnosis and neonatal management. Congenit Heart Dis; 2008 Nov-Dec;3(6):449-51
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  • Intrapericardial teratoma is a rare and often fatal germ-cell tumor of neonates.
  • It is usually histologically benign but may cause death in utero by hydrops fetalis or by pericardial tamponade in the early days of life.

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  • (PMID = 19037988.001).
  • [ISSN] 1747-0803
  • [Journal-full-title] Congenital heart disease
  • [ISO-abbreviation] Congenit Heart Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. You YN, Leibovitch BC, Que FG: Hepatic metastasectomy for testicular germ cell tumors: is it worth it? J Gastrointest Surg; 2009 Apr;13(4):595-601
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  • [Title] Hepatic metastasectomy for testicular germ cell tumors: is it worth it?
  • BACKGROUND: Chemotherapy is highly effective for metastatic germ cell tumor (GCT), but experience with resection of hepatic metastases from GCT is limited.
  • Hepatic histology included: necrosis (33%), viable tumor (27%), mature teratoma (13%), and benign histology (27%).
  • Concomitant resection of extrahepatic disease (14 patients, 93%) found necrosis (53%), mature teratoma (27%), and viable tumor (13%).
  • At 8.2 years (mean) from resection, 11 patients (73%) were alive: five with no evidence of disease, two with elevated tumor marker only, and four with gross disease.
  • [MeSH-major] Hepatectomy. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / secondary

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  • [Cites] Ann Surg. 2005 Aug;242(2):260-6 [16041217.001]
  • [Cites] J Clin Oncol. 1997 Feb;15(2):594-603 [9053482.001]
  • [Cites] N Engl J Med. 1997 Jul 24;337(4):242-53 [9227931.001]
  • [Cites] J Urol. 2004 Jan;171(1):168-71 [14665869.001]
  • [Cites] J Urol. 2004 May;171(5):1835-8 [15076288.001]
  • [Cites] Ann Surg. 2008 Jan;247(1):125-35 [18156932.001]
  • [Cites] J Clin Oncol. 2006 Dec 10;24(35):5512-8 [17158536.001]
  • [Cites] Ann Thorac Surg. 1998 Nov;66(5):1709-14 [9875776.001]
  • [Cites] J Urol. 2006 Nov;176(5):1921-6 [17070212.001]
  • [Cites] J Clin Oncol. 2007 Dec 10;25(35):5603-8 [17998544.001]
  • [Cites] Cancer. 2003 Jan 1;97(1):63-70 [12491506.001]
  • [Cites] Cancer. 2001 Aug 1;92(3):578-87 [11505402.001]
  • [Cites] Curr Ther Endocrinol Metab. 1997;6:387-92 [9174777.001]
  • [Cites] J Clin Oncol. 2007 Mar 20;25(9):1033-7 [17261854.001]
  • [Cites] Ann Surg. 1990 Sep;212(3):290-3; discussion 293-4 [2168694.001]
  • [Cites] Urol Clin North Am. 2007 May;34(2):235-43; abstract x [17484928.001]
  • [Cites] Ann Surg Oncol. 2008 Jan;15(1):207-18 [17963007.001]
  • [Cites] J Pathol. 2007 Sep;213(1):65-71 [17634958.001]
  • [Cites] Ann Oncol. 2006 Sep;17 Suppl 10:x31-5 [17018745.001]
  • [Cites] Urol Clin North Am. 2007 May;34(2):199-217; abstract ix [17484925.001]
  • [Cites] Surgery. 2007 Jan;141(1):9-18 [17188163.001]
  • [Cites] Semin Urol Oncol. 2002 Nov;20(4):262-71 [12489059.001]
  • [Cites] Ann Surg Oncol. 1999 Oct-Nov;6(7):640-4 [10560848.001]
  • [Cites] Urol Clin North Am. 2007 May;34(2):187-97; abstract ix [17484924.001]
  • [Cites] Ann Oncol. 2004 Sep;15(9):1377-99 [15319245.001]
  • (PMID = 19190967.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


23. Spurlock G, Knight SJ, Thomas N, Kiehl TR, Guha A, Upadhyaya M: Molecular evolution of a neurofibroma to malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings. J Cancer Res Clin Oncol; 2010 Dec;136(12):1869-80
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  • [Title] Molecular evolution of a neurofibroma to malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings.
  • OBJECTIVE: Neurofibromatosis type 1 (NF1) patients have a 13% risk of developing a malignant peripheral nerve sheath tumor (MPNST).
  • Many MPNSTs are histopathologically complex, with regions exhibiting features of the original benign plexiform neurofibroma (PNF), of an atypical PNF, or of MPNST showing varying degrees of de-differentiation.
  • This study analyzed the genetic alterations associated with this pathological heterogeneity in order to identify the genetic processes involved in transformation from a benign to an aggressive malignant tumor.
  • METHODS: A histological and molecular analysis of a single MPNST tumor that was subdivided into three histopathologically distinct regions, a benign PNF (region 1), an atypical PNF (region 2), and a high-grade MPNST (region 3), was carried out.
  • Tumor DNA from each region was analyzed in conjunction with the patient's lymphocyte DNA.
  • The NF1-associated LOH analysis found that LOH increased in the three tumor areas, with 9, 42, and 97% LOH evident in regions 1, 2, and 3, respectively.
  • Additional genetic changes, including losses of TP53, RB1, CDKN2A, and of several oncogenes and cell-cycle genes, were found only in the malignant MPNST (region 3).
  • [MeSH-minor] Adult. Base Sequence. Comparative Genomic Hybridization. DNA Mutational Analysis. Disease Progression. Germ-Line Mutation. Humans. Loss of Heterozygosity. Male. Molecular Sequence Data


24. Brems H, Park C, Maertens O, Pemov A, Messiaen L, Upadhyaya M, Claes K, Beert E, Peeters K, Mautner V, Sloan JL, Yao L, Lee CC, Sciot R, De Smet L, Legius E, Stewart DR: Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association. Cancer Res; 2009 Sep 15;69(18):7393-401
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  • Neurofibromatosis type 1 (NF1) is a common disorder that arises secondary to mutations in the tumor suppressor gene NF1.
  • Glomus tumors are small, benign but painful tumors that originate from the glomus body, a thermoregulatory shunt concentrated in the fingers and toes.
  • In 12 NF1-associated glomus tumors, we used cell culture and laser capture microdissection to isolate DNA.
  • Genetic analysis showed germ line and somatic NF1 mutations in seven tumors.
  • Glomus tumors of the fingers or toes should be considered as part of the tumor spectrum of NF1.
  • [MeSH-major] Glomus Tumor / genetics. Neurofibromatosis 1 / genetics
  • [MeSH-minor] Actins / biosynthesis. Adolescent. Adult. Child. Comparative Genomic Hybridization. Female. Fibroblasts / metabolism. Fibroblasts / physiology. Gene Dosage. Gene Silencing. Genes, Neurofibromatosis 1. Humans. MAP Kinase Signaling System. Male. Middle Aged. Polymerase Chain Reaction. Receptors, Androgen / metabolism. Skin / cytology. Tumor Cells, Cultured. Young Adult. ras Proteins / metabolism

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  • [Cites] Hum Mutat. 1999;14(5):387-93 [10533064.001]
  • [Cites] N Engl J Med. 2002 Sep 12;347(11):854-5; author reply 854-5 [12226162.001]
  • [Cites] Leukemia. 2000 Jan;14(1):207-12 [10637497.001]
  • [Cites] Hum Mutat. 2000;15(6):541-55 [10862084.001]
  • [Cites] J Dermatol. 2000 Jun;27(6):418-9 [10920593.001]
  • [Cites] Cell. 2001 Feb 23;104(4):593-604 [11239415.001]
  • [Cites] Genes Dev. 2003 Feb 15;17(4):449-54 [12600938.001]
  • [Cites] Nat Genet. 2004 Apr;36(4):411-6 [15004558.001]
  • [Cites] Curr Hematol Rep. 2004 May;3(3):203-9 [15087069.001]
  • [Cites] Nucleic Acids Res. 2004;32(8):2529-40 [15133121.001]
  • [Cites] J Hand Surg Am. 1977 Jul;2(4):261-5 [197147.001]
  • [Cites] Cancer. 1982 Oct 15;50(8):1601-7 [6288219.001]
  • [Cites] Cancer Res. 1985 Apr;45(4):1437-43 [2983882.001]
  • [Cites] Science. 1990 Jul 13;249(4965):181-6 [2134734.001]
  • [Cites] Cell. 1990 Nov 16;63(4):843-9 [2121370.001]
  • [Cites] Nucleic Acids Res. 1991 Jul 11;19(13):3764 [1906608.001]
  • [Cites] Hum Mol Genet. 1993 Jun;2(6):725-30 [8353492.001]
  • [Cites] Hum Genet. 1993 Oct;92(4):429-30 [8225327.001]
  • [Cites] Hum Genet. 1994 Mar;93(3):351-2 [8125490.001]
  • [Cites] J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):277-8 [7829715.001]
  • [Cites] J Hand Surg Br. 1996 Apr;21(2):257-60 [8732413.001]
  • [Cites] Am J Hum Genet. 1997 Sep;61(3):512-9 [9326316.001]
  • [Cites] Hum Genet. 1999 Jan;104(1):49-55 [10071192.001]
  • [Cites] Cell. 1999 Mar 5;96(5):737-49 [10089888.001]
  • [Cites] J Dermatol. 1999 Aug;26(8):535-7 [10487011.001]
  • [Cites] J Heart Lung Transplant. 2005 Nov;24(11):1915-29 [16297800.001]
  • [Cites] Hum Mol Genet. 2006 Mar 15;15(6):1015-23 [16461335.001]
  • [Cites] J Hand Surg Am. 2006 Oct;31(8):1397-400 [17027805.001]
  • [Cites] Matrix Biol. 2007 Jan;26(1):30-41 [17074475.001]
  • [Cites] PLoS Comput Biol. 2007 Apr 20;3(4):e72 [17447839.001]
  • [Cites] Fam Cancer. 2007;6(1):21-34 [16944272.001]
  • [Cites] Am J Hum Genet. 2007 Aug;81(2):243-51 [17668375.001]
  • [Cites] Hum Mutat. 2008 Jan;29(1):74-82 [17960768.001]
  • [Cites] Mol Cancer. 2008;7:8 [18211683.001]
  • [Cites] J Med Genet. 2008 Oct;45(10):622-31 [18511569.001]
  • [Cites] Lancet Oncol. 2009 May;10(5):508-15 [19410195.001]
  • [Cites] Nucleic Acids Res. 2002 Jun 15;30(12):e57 [12060695.001]
  • [Cites] J Med Genet. 2002 Aug;39(8):e45 [12161612.001]
  • [ErratumIn] Cancer Res. 2009 Oct 15;69(20):8216. Messia, Ludwine [corrected to Messiaen, Ludwine]
  • (PMID = 19738042.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HG200329-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Receptors, Androgen; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS135382; NLM/ PMC2747722
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25. Hoffman JG, Strickland JL, Yin J: Virilizing ovarian dermoid cyst with leydig cells. J Pediatr Adolesc Gynecol; 2009 Jun;22(3):e39-40
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  • The most frequent germ cell tumor derived from the ovaries is the benign cystic teratoma (dermoid) which accounts for 25% of all ovarian neoplasms.
  • CONCLUSION: Benign cystic teratomas can produce active hormones, albeit rarely.
  • This is a finding important to consider when ovarian cystectomy is performed for removal of a benign cystic teratoma.

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  • (PMID = 19539195.001).
  • [ISSN] 1873-4332
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone
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26. De Moura J, Kavalec FL, Doghman M, Rosati R, Custodio G, Lalli E, Cavallari GM, Santa Maria J, Figueiredo BC: Heterozygous TP53stop146/R72P fibroblasts from a Li-Fraumeni syndrome patient with impaired response to DNA damage. Int J Oncol; 2010 Apr;36(4):983-90
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  • In order to investigate the disruption of the p53 function in a patient presenting this mutation and the TP53Arg72Pro polymorphism who had so far suffered five malignant tumors and a benign meningioma, we tested her fibroblasts in response to DNA damage by evaluating the proliferation rate, apoptosis, and disruption of the TP53 pathway.
  • The proband's heterozygous fibroblasts were not as efficient as control fibroblasts or those of her mother, who carried only the TP53Arg72Pro polymorphism, in causing cell arrest and cell death after DNA damage, which was correlated with diminished TP21 protein levels.
  • [MeSH-major] Codon, Nonsense. DNA Damage. Fibroblasts / metabolism. Germ-Line Mutation. Li-Fraumeni Syndrome / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Antineoplastic Agents, Phytogenic / pharmacology. Apoptosis. Cell Cycle. Cell Proliferation. Cells, Cultured. Codon, Terminator. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Etoposide / pharmacology. Female. Genotype. Heterozygote. Humans. Male. Middle Aged. Pedigree. Phenotype. Polymorphism, Genetic

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  • (PMID = 20198344.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / CDKN1A protein, human; 0 / Codon, Nonsense; 0 / Codon, Terminator; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 6PLQ3CP4P3 / Etoposide
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27. Dong Z, Yang Z, Li Y, Min P, Zhang X: [Extra-organic primary tumor in pelvis: correlation of multi-detector row computed tomography, anatomy and pathology]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2009 Feb;26(1):75-9
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  • [Title] [Extra-organic primary tumor in pelvis: correlation of multi-detector row computed tomography, anatomy and pathology].
  • The majority of entities in these 2 pouches were germ cell tumors (3/5 cases, 60.0%).
  • The majority entities of these 10 cases were germ cell tumors (7/10 cases, 70.0%).
  • The fatty element occurred in 7 masses, including 4 cases of teratoma, 1 case of malignant teratoma, 1 case of mixed germ cell tumor, and 1 case of liposarcoma.
  • MDCT with multi-planar reconstruction (MPR) could more clearly reveal the anatomic location of the extra-organic primary tumor in pelvis, could unveil the tumor's relationship with its surrounding organs, and could help to differentiate benign tumors from malignant tumors.

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  • (PMID = 19334559.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Liberis V, Tsikouras P, Sivridis E, Dadidou M, Koutlaki N, Galazios G: Irregular dental structures in a benign ovarian cystic teratoma (dermoid cyst): case report. Clin Exp Obstet Gynecol; 2008;35(2):151-2
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  • [Title] Irregular dental structures in a benign ovarian cystic teratoma (dermoid cyst): case report.
  • Mature cystic teratomas, often referred to as dermoid cysts, are the most common germ cell tumors of the ovary in women of reproductive age.
  • We present a case of a dermoid cyst ovarian tumor in a 24-your-old patient with a tooth lying on each wall.

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  • (PMID = 18581775.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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29. Hermsen MA, Sevilla MA, Llorente JL, Weiss MM, Grimbergen A, Allonca E, Garcia-Inclán C, Balbín M, Suárez C: Relevance of germline mutation screening in both familial and sporadic head and neck paraganglioma for early diagnosis and clinical management. Cell Oncol; 2010 Jan 1;32(4):275-83
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  • BACKGROUND: Head and neck paraganglioma (PGL) are benign tumors that can cause important direct or surgery induced morbidity.
  • Results were correlated to clinical characteristics including gender, age, tumor localization and multifocality.
  • The surgical approach was evaluated in terms of tumor origin, sequelae and subsequent evolution.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Early Detection of Cancer / methods. Female. Genetic Predisposition to Disease. Germ-Line Mutation / genetics. Humans. Male. Middle Aged. Pedigree. Predictive Value of Tests. Sex Factors. Spain

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  • (PMID = 20208144.001).
  • [ISSN] 1875-8606
  • [Journal-full-title] Cellular oncology : the official journal of the International Society for Cellular Oncology
  • [ISO-abbreviation] Cell. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Other-IDs] NLM/ PMC4619289
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30. De Backer A, Madern GC, Hazebroek FW: Retroperitoneal germ cell tumors: a clinical study of 12 patients. J Pediatr Surg; 2005 Sep;40(9):1475-81
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  • [Title] Retroperitoneal germ cell tumors: a clinical study of 12 patients.
  • PURPOSE: The aim of the study was to examine the clinical presentation, method(s) of treatment, complications, and results in newborns and infants with retroperitoneal germ cell tumors (GCTs).
  • Symptoms in these 8 boys and 4 girls were abdominal distension and a palpable upper abdominal mass, right-sided in 5, left-sided in 5, and central in 2; the tumor was usually big.
  • The patients with YSTs underwent surgical biopsy, followed by chemotherapy and excision of the remaining tumor and of the metastases.
  • No adjuvant treatment was administered in the patients with benign disease.
  • Nine survivors with benign tumor are disease-free between 1 and 30 years after surgery.
  • Surgical removal of the tumors appeared to be hazardous because of the extent of the tumor, the displacement and elongation of adjacent structures and organs, and/or the adhesion of the tumor to surrounding tissues; this resulted in several perioperative complications.
  • The long-term results are good, however, with 9 of 10 patients with benign tumors in good health after a mean follow-up of 12 years, and with the 2 patients with YST in remission for 6 and 5 years, respectively.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal. Retroperitoneal Neoplasms

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  • (PMID = 16150352.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Kumamoto H, Ohki K, Ooya K: Expression of p63 and p73 in ameloblastomas. J Oral Pathol Med; 2005 Apr;34(4):220-6
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  • METHODS: Tissue specimens of nine tooth germs and 48 benign and five malignant ameloblastomas were examined by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) for the expression of p63 and p73.
  • RESULTS: Immunoreactivity for p63 and p73 was evident in epithelial cells neighboring the basement membrane in developing and neoplastic odontogenic tissues. p63 expression in desmoplastic ameloblastomas was significantly higher than in acanthomatous and granular cell ameloblastomas, and ameloblastic carcinomas showed higher p63 expression than metastasizing ameloblastomas. p73 expression was significantly higher in plexiform ameloblastomas than in follicular ameloblastomas, and basal cell ameloblastomas showed higher p73 expression than granular cell ameloblastomas. mRNA transcripts for Delta Np63 and TAp73 were detected in all developing and neoplastic odontogenic tissues.
  • [MeSH-major] Ameloblastoma / genetics. Apoptosis / genetics. DNA-Binding Proteins / genetics. Genes, Tumor Suppressor. Nuclear Proteins / genetics. Phosphoproteins / genetics. Trans-Activators / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Basement Membrane / metabolism. Cell Differentiation / genetics. Cell Proliferation. Epithelial Cells / metabolism. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry. Protein Isoforms / genetics. Reverse Transcriptase Polymerase Chain Reaction. Tooth Germ / metabolism. Transcription Factors. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 15752257.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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32. Radovanovic I, Dizdarevic K, de Tribolet N, Masic T, Muminagic S: Pineal region tumors--neurosurgical review. Med Arh; 2009;63(3):171-3
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  • The treatment for the pineal region tumors depends on tumor histology.
  • For benign pineal tumors (pineocytoma, meningioma, mature teratomas, symptomatic pineal cysts, etc.) radical surgical resection can be curative.
  • Serum and CSF markers contribute to the diagnosis of pineal parenchymal tumors. b-HCG is mainly positive in choriocarcinomas, embryonal carcinomas and mixed germ cell tumors and AFP is expressed by yolk sac tumors, embryonic carcinomas, immature teratomas and mixed germ cell tumors, b-HCG is usually low in germinomas which are often positive for PLAP on immunohistochemistry.

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  • (PMID = 20088167.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Bosnia and Herzegovina
  • [Number-of-references] 10
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33. Uglialoro AD, Beebe KS, Hameed M, Benevenia J: A rare case of intraosseous benign notochordal cell tumor of the coccyx. Orthopedics; 2009 Jun;32(6):445
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  • [Title] A rare case of intraosseous benign notochordal cell tumor of the coccyx.
  • An excisional biopsy revealed benign notochord cell tumor.
  • Due to the rarity of intraosseous benign notochordal cell tumors, it is essential to document and review this type of tumor.
  • Only 2 benign notochordal cell tumors involving the coccyx have been previously reported, both of which presented with the same clinical symptoms of chronic coccydynia as our patient, likely due to the location of the involved lesion.
  • The other leading diagnosis in our patient was chordoma, a malignant and locally aggressive neoplasm that is important to consider and exclude.
  • Although chordomas have been well characterized in the surgery, pathology, and radiology literature, the benign notochordal cell tumor is a relative newcomer.
  • [MeSH-major] Coccyx / surgery. Low Back Pain / etiology. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery

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  • (PMID = 19634813.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Zynger DL, Dimov ND, Luan C, Teh BT, Yang XJ: Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol; 2006 Dec;30(12):1570-5
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  • [Title] Glypican 3: a novel marker in testicular germ cell tumors.
  • Glypican 3 (GPC3), a membrane-bound heparin sulfate proteoglycan, may play a role in promoting embryonic cell growth and differentiation.
  • However, the presence of the GPC3 protein in germ cell tumors has never been investigated.
  • The purpose of the study was to investigate the GPC3 expression in various histologic components of testicular germ cell tumors using immunohistochemistry and to assess its possible utility as a diagnostic marker.
  • All yolk sac tumor (24/24) and choriocarcinoma (7/7) components were immunoreactive for GPC3, whereas only 38% of teratomas with immature elements and 8% of embryonal carcinomas expressed GPC3.
  • There was no immunoreactivity in benign testicular tissue, intratubular germ cell neoplasia, seminomas (0/42), or teratomas with mature elements (0/20).
  • We conclude that the oncofetal protein GPC3 is a novel immunohistochemical marker in testicular germ cell tumors with differential expression in defined histologic subtypes.
  • Our findings suggest a possible role of GPC3 in tumor cell differentiation.
  • Furthermore, GPC immunostaining may be useful in the pathologic diagnosis of nonseminomatous germ cell tumors, particularly yolk sac tumor, and choriocarcinoma.
  • [MeSH-major] Glypicans / metabolism. Neoplasms, Germ Cell and Embryonal / metabolism. Testicular Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Fluorescent Antibody Technique, Indirect. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17122513.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPC3 protein, human; 0 / Glypicans
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35. Cheng L, Zhang S, MacLennan GT, Poulos CK, Sung MT, Beck SD, Foster RS: Interphase fluorescence in situ hybridization analysis of chromosome 12p abnormalities is useful for distinguishing epidermoid cysts of the testis from pure mature teratoma. Clin Cancer Res; 2006 Oct 1;12(19):5668-72
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  • PURPOSE: The distinction of epidermoid cyst of the testis from teratoma is of critical importance because the former is benign and the latter is a malignant tumor that may have associated metastasis of either teratomatous or non-teratomatous germ cell tumor types.
  • Chromosome 12p abnormalities are seen in the vast majority of testicular germ cell tumors of adults and are present in all histologic subtypes.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Humans. Interphase. Karyotyping. Male. Tumor Cells, Cultured

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  • (PMID = 17020968.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Tomas D, Lenicek T, Tuckar N, Puljiz Z, Ledinsky M, Kruslin B: Primary ovarian leiomyoma associated with endometriotic cyst presenting with symptoms of acute appendicitis: a case report. Diagn Pathol; 2009;4:25
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  • BACKGROUND: Ovarian leiomyoma is a rare benign tumor that accounts for 0.5 to 1% of all benign ovarian tumors.
  • It probably arises from smooth muscle cells in the ovarian hilar blood vessels but there are other possible origins including cells in the ovarian ligament, smooth muscle cells or multipotential cells in the ovarian stroma, undifferentiated germ cells, or cortical smooth muscle metaplasia.
  • Additionally, smooth muscle metaplasia of endometriotic stroma, smooth muscle present in mature cystic teratomas, and smooth muscle in the walls of mucinous cystic tumor may explain their occurrence in the ovary in some cases.
  • Upon laparotomy, there was a solid, oval left-sided ovarian tumor located behind the uterus.
  • The tumor was sent to the pathology department.
  • In our case, the tumor probably arose from smooth muscle cells derived from myofibroblasts that originate from metaplastic ovarian stromal cells present in the rim of the endometriotic cyst.
  • Despite its rarity, ovarian leiomyoma should be considered in the differential diagnosis of ovarian spindle cell tumors.

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  • [Cites] Int J Surg Pathol. 2009 Feb;17(1):38-40 [18397899.001]
  • [Cites] Histopathology. 2000 Apr;36(4):348-52 [10759949.001]
  • [Cites] Gynecol Oncol. 2004 Dec;95(3):733-5 [15581993.001]
  • [Cites] Cancer. 1961 Sep-Oct;14:989-1000 [13752348.001]
  • [Cites] Int J Gynecol Pathol. 1999 Jan;18(1):63-8 [9891243.001]
  • [Cites] Int J Gynecol Pathol. 1999 Jan;18(1):58-62 [9891242.001]
  • [Cites] Gynecol Oncol. 1997 Nov;67(2):226-9 [9367713.001]
  • [Cites] Obstet Gynecol. 1996 May;87(5 Pt 2):872-3 [8677121.001]
  • [Cites] Arch Pathol Lab Med. 1993 Aug;117(8):802-8 [7688213.001]
  • [Cites] Arch Pathol Lab Med. 1992 Oct;116(10):1068-71 [1417447.001]
  • [Cites] Am J Surg Pathol. 1991 Nov;15(11):1055-62 [1656803.001]
  • [Cites] Am J Obstet Gynecol. 1989 Jul;161(1):177-8 [2750800.001]
  • [Cites] Arch Pathol Lab Med. 1981 Oct;105(10):505-7 [6895159.001]
  • [Cites] J Obstet Gynaecol. 1999 Nov;19(6):676 [15512440.001]
  • [Cites] J Obstet Gynaecol. 1997 Sep;17(5):503-4 [15511944.001]
  • [Cites] Am J Surg Pathol. 2004 Nov;28(11):1436-51 [15489647.001]
  • [Cites] Mod Pathol. 2003 Jun;16(6):584-90 [12808064.001]
  • [Cites] Clin Imaging. 2000 Jan-Feb;24(1):34-7 [11120415.001]
  • [Cites] J Pediatr Adolesc Gynecol. 2008 Feb;21(1):33-6 [18312799.001]
  • (PMID = 19642987.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2724421
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37. Litten JB, Tomlinson GE: Liver tumors in children. Oncologist; 2008 Jul;13(7):812-20
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  • The embryonal tumor, hepatoblastoma, accounts for two thirds of malignant liver tumors in children.
  • Other liver malignancies in children include hepatocellular carcinoma, sarcomas, germ cell tumors, and rhabdoid tumors.
  • Benign tumors of the liver in children include vascular tumors, hamartomas, and adenomas.

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  • (PMID = 18644850.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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38. Nakajima J: [Surgical therapy for elderly patients with mediastinal neoplasms except for thymic epithelial tumors]. Kyobu Geka; 2005 Jul;58(8 Suppl):745-50
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  • Two of them had malignant neoplasms (a germ cell tumor and a malignant fibrous histiocytoma).
  • A 76-year-old patient with a malignant germ cell tumor had undergone reexploration because of persistent air leakage from the bronchopleural fistula.
  • Surgical procedures were practically performed to determine the pathological diagnosis or to treat the patients with pathologically benign neoplasms because of diverse biological behaviors of these mediastinal tumors.
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Combined Modality Therapy. Fatal Outcome. Female. Germinoma / diagnosis. Germinoma / surgery. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / surgery. Humans. Male. Postoperative Care. Prognosis. Retrospective Studies. Thoracoscopy. Tomography, X-Ray Computed

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  • (PMID = 16097630.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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39. Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S: Teratomas in central nervous system: a clinico-morphological study with review of literature. Neurol India; 2010 Nov-Dec;58(6):841-6
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  • Histopathology is diagnostic; most of the lesions are benign.
  • Of these, 11 were mature cystic teratomas; and 1 case each, of teratoma with malignant transformation, terato-carcinoma and mixed germ cell tumor (immature teratoma with germinoma).
  • Radiologically, contrast enhancement with predominantly solid component was suggestive of malignancy or an aggressive tumor.
  • Excision was curative or provided symptomatic relief in most cases; terato-carcinoma and mixed germ cell tumor patients needed adjuvant radiotherapy.

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  • (PMID = 21150046.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
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40. Kumamoto H, Ooya K: Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors. J Oral Pathol Med; 2006 Nov;35(10):606-12
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  • [Title] Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors.
  • BACKGROUND: To evaluate the roles of angiogenic factors in the development and progression of odontogenic tumors, expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) and of angiopoietins in ameloblastic tumors as well as in tooth germs.
  • Granular cell ameloblastomas showed PD-ECGF/TP reactivity in granular neoplastic cells as well as in stromal cells.
  • Immunoreactivity for angiopoietin-1 and -2 was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and in benign and malignant ameloblastic tumors.
  • CONCLUSION: Expression of PD-ECGF/TP and angiopoietin-1 and -2 in tooth germs and ameloblastic tumors suggests that these angiogenic factors participate in tooth development and odontogenic tumor progression by regulating angiogenesis.
  • Altered expression of PD-ECGF/TP and angiopoietins in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-minor] Humans. Stromal Cells / chemistry. Stromal Cells / enzymology. Tooth Germ / chemistry. Tooth Germ / enzymology

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  • (PMID = 17032393.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ANGPT1 protein, human; 0 / Angiopoietin-1; 0 / Angiopoietin-2; EC 2.4.2.4 / Thymidine Phosphorylase
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41. Van Cauwelaert Rojas R, Ruiz-Tagle Phillips D, Meneses Ciuffardi M, Carrasco Troncoso AM, Aguirre Aguirre C: [Three cases of unusual non-germ cell tumors of the testicle]. Actas Urol Esp; 2007 Sep;31(8):923-7
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  • [Title] [Three cases of unusual non-germ cell tumors of the testicle].
  • By describing 3 clinical cases of unusual testicular non germinal tumors, including an adenoma of the rete testis, an undifferenciated sex cord tumor and a mesothelioma of the tunica vaginalis, we make a literature review of the unusual testicular tumors and testicular apendix, including their incidence and management.
  • Also and as one of our conclusions, we expose the importance of the intraoperatory biopsy in the testicular cancer surgery, because even if it is infrecuent, the presence of this rare testicular tumors, in which if they are proven to be benign, the testicular unit could be preserved and the radical orquiectomy could be avoided.

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  • (PMID = 18020219.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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42. Fakhr IM, Khalil el-SA, El-Baradie TS, Shaalan MA, Shalaby LM, Nassif SL, Farahat IG: The role of surgical management in pediatric germ cell tumors (GCTs), NCI case series. J Egypt Natl Canc Inst; 2008 Mar;20(1):70-9
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  • [Title] The role of surgical management in pediatric germ cell tumors (GCTs), NCI case series.
  • PURPOSE: To review the experience of a tertiary referral center in pediatric germ cell tumors (GCTs) in the last 8 years and to investigate the impact of surgery and site of disease on prognosis.
  • PATIENTS AND METHODS: We retrospectively analyzed the cases of pediatric germ cell tumors at National Cancer Institute over an 8 years period.
  • One patient with benign GCT was excluded during analysis of the results.
  • Yolk sac tumor and malignant teratoma were the commonest histologic subtypes in our series.
  • CONCLUSION: The initial surgical approach to malignant GCTs at all sites should be complete resection when possible; the morbidity of extensive surgical resection should be weighed carefully against the good tumor control with chemotherapy.
  • The site of primary disease plays a role in the prognosis of pediatric germ cell tumors with the extragonadal pelvic tumors being the worst regarding resectability.
  • Good tumor response can be achieved with surgery and chemotherapy even for advanced stage and metastatic disease.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Humans. Infant. Lymphatic Metastasis. Male. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 19847284.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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43. Ben Temime R, Chachial A, Attial L, Ghodbanel I, Makhloufl T, Koubaal A, Kourda N, Ben Jilani S, Dammak T, El May A, Rahal K: 46 XY pure gonadal dysgenesis with gonadoblastoma and dysgerminoma. Tunis Med; 2008 Jul;86(7):710-3
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  • The tumor that usually develops in Swyer syndrome is gonadoblastoma.
  • Although gonadoblastoma is considered benign, the risk of malignant germ cell tumor development is high.
  • OBJECTIVE: The aim of this report is to stress on the risk of occurrence of malignant germ cell tumors on these dysgenesic gonads.


44. Schmidt D, Kommoss F: [Teratoma of the ovary. Clinical and pathological differences between mature and immature teratomas]. Pathologe; 2007 May;28(3):203-8
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  • Teratomas are the most frequent germ cell tumors of the ovary.
  • Mature teratomas are benign tumors, which are most often composed of derivatives of two or three germ cell layers.
  • Only in rare cases is the transition into a malignant tumor observed (most often squamous cell carcinoma).
  • Histologically, this tumor component can be identified as neurotubules or rosettes.
  • In childhood cases, foci of yolk sac tumor (YST) must be looked for, since this determines the prognosis.

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  • [Cites] Arch Pathol Lab Med. 1978 Aug;102(8):420-5 [580884.001]
  • [Cites] Pathol Res Pract. 1989 Apr;184(4):422-30 [2726609.001]
  • [Cites] N Engl J Med. 1975 Jan 9;292(2):63-6 [162806.001]
  • [Cites] Hum Pathol. 2004 Jun;35(6):685-8 [15188134.001]
  • [Cites] Mod Pathol. 2006 Jun;19(6):766-71 [16547466.001]
  • [Cites] Mod Pathol. 1997 Jun;10(6):597-601 [9195578.001]
  • [Cites] Am J Surg Pathol. 1998 Sep;22(9):1115-24 [9737245.001]
  • [Cites] Am J Surg Pathol. 1993 Aug;17(8):764-78 [8393302.001]
  • [Cites] Klin Padiatr. 2006 Nov-Dec;218(6):296-302 [17080330.001]
  • [Cites] J Clin Pathol. 1983 Jan;36(1):68-73 [6822679.001]
  • [Cites] Int J Oncol. 2004 Jul;25(1):17-25 [15201985.001]
  • [Cites] Int J Gynecol Pathol. 2005 Apr;24(2):173-82 [15782074.001]
  • [Cites] Ann Oncol. 2000 Mar;11(3):263-71 [10811491.001]
  • [Cites] Am J Obstet Gynecol. 1946 Feb;51:151-72 [21012750.001]
  • [Cites] Mod Pathol. 2005 Feb;18 Suppl 2:S61-79 [15761467.001]
  • [Cites] APMIS. 2003 Jan;111(1):152-60; discussion 160 [12752256.001]
  • [Cites] Am J Obstet Gynecol. 1999 Aug;181(2):353-8 [10454682.001]
  • [Cites] Int J Gynecol Pathol. 2002 Jan;21(1):82-5 [11781530.001]
  • [Cites] Cancer. 1976 May;37(5):2359-72 [1260722.001]
  • (PMID = 17396268.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


45. Rabban JT, Crawford B, Chen LM, Powell CB, Zaloudek CJ: Transitional cell metaplasia of fallopian tube fimbriae: a potential mimic of early tubal carcinoma in risk reduction salpingo-oophorectomies from women With BRCA mutations. Am J Surg Pathol; 2009 Jan;33(1):111-9
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  • [Title] Transitional cell metaplasia of fallopian tube fimbriae: a potential mimic of early tubal carcinoma in risk reduction salpingo-oophorectomies from women With BRCA mutations.
  • Transitional cell metaplasia is a benign epithelial alteration that is a common finding in the serosa of the tube but is underrecognized in the tubal fimbriae, where it may mimic tubal intraepithelial carcinoma.
  • The aim of this study was to define the incidence, morphology, immunophenotype, and distribution of transitional cell metaplasia of the fimbriae in RRSO specimens from 96 women with BRCA germline mutations and to compare these features to those of tubal intraepithelial carcinoma in this cohort.
  • Transitional cell metaplasia of the fimbriae was present in 26% of all RRSO specimens.
  • Median tumor size was 2.7 mm (range: 1 to 11 mm).
  • The key criteria distinguishing transitional cell metaplasia from tubal intraepithelial carcinoma were uniform cell size and shape, normal nucleus:cytoplasm ratios, lack of nuclear atypia, presence of nuclear grooves, lack of mitoses, and absence of p53 expression or increased staining for MIB-1.
  • No particular clinical variables (BRCA 1 vs. BRCA 2 mutation, parity, personal history of breast cancer, prior abdomino-pelvic surgery, or intraoperative findings) or benign pathologic alterations in the RRSO specimens were associated with the presence of transitional cell metaplasia of the fimbriae.
  • This study demonstrates that transitional cell metaplasia of the fimbriae is a common benign finding in RRSO specimens that should not be confused with the much less common finding of tubal intraepithelial carcinoma.
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Genes, BRCA1. Genes, BRCA2. Germ-Line Mutation. Humans. Immunohistochemistry. Metaplasia. Middle Aged. Ovariectomy. Risk Factors. Tumor Suppressor Protein p53 / metabolism


46. Denayer E, Devriendt K, de Ravel T, Van Buggenhout G, Smeets E, Francois I, Sznajer Y, Craen M, Leventopoulos G, Mutesa L, Vandecasseye W, Massa G, Kayserili H, Sciot R, Fryns JP, Legius E: Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations. Genes Chromosomes Cancer; 2010 Mar;49(3):242-52
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  • [Title] Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations.
  • One was classified as a rare benign variant and the other remains unclassified.
  • Three patients with SOS1 mutations presented with tumors (embryonal rhabdomyosarcoma, Sertoli cell testis tumor, and granular cell tumors of the skin).
  • One patient with a RAF1 mutation had a lesion suggestive for a giant cell tumor.
  • This is the first report describing different tumor types in NS patients with germ line SOS1 mutations.


47. Shi Y, Liu Z, Peng Z, Liu H, Yang K, Yao X: The diagnosis and treatment of Mullerian adenosarcoma of the uterus. Aust N Z J Obstet Gynaecol; 2008 Dec;48(6):596-600
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  • RESULTS: Patients typically presented with abnormal uterine bleeding, pain in the lower abdomen, enlargement of the uterus, a mass in the uterine cavity and/or a cervical neoplasm.
  • Microscopically, the glands were lined by benign or atypical glandular epithelium, together with sarcomatous stromal cells which showed characteristic structures of 'periglandular cuff' of increased cellularity and 'intraglandular polypoid projections'.
  • [MeSH-major] Adenosarcoma / diagnosis. Mixed Tumor, Mullerian / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Uterine Cervical Neoplasms / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Age Factors. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Treatment Outcome. Young Adult


48. Scolozzi P, Marret N, Bouzourene H, Luthi F, Bauer J, Jaques B, Lombardi T: Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving the maxillary gingiva. J Oral Pathol Med; 2006 Oct;35(9):579-81
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  • [Title] Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving the maxillary gingiva.
  • Because of their unremarkable clinical appearance, they can be difficult to distinguish from more common gingival hyperplastic or reactive lesions, such as pyogenic granuloma, peripheral giant cell granuloma, and peripheral ossifying granuloma.
  • We are reporting here an unusual case of a 36-year-old man with a mixed testicular germ cell tumor presenting as a metastatic pure choriocarcinoma involving the maxillary gingiva, extending from the first left premolar to the left second maxillary molar, mimicking a 'benign looking' gingival mass.
  • [MeSH-major] Choriocarcinoma / secondary. Gingival Neoplasms / secondary. Mixed Tumor, Malignant / secondary. Neoplasms, Germ Cell and Embryonal / secondary. Testicular Neoplasms

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  • (PMID = 16968241.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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49. Antón L, Pérez-Etchepare E, Soriano D, Gómez M, Barrientos G, Tracchia R: [Testicular tumors: wide spectrum in our short casuistics]. Cir Pediatr; 2010 Oct;23(4):222-4
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  • The pathology determines the specific cell.
  • We report seven cases, three germ cell tumors: a Yolk sac tumor in a child of 18 months and two mature teratomas in children between 2 and 11 years presenting as a painless testicular mass without other symptoms.
  • Testis-sparing surgery in Leydig cell tumor and resection of the paratesticular mass was performed through scrotal.
  • The Yolk sac tumor requiring chemotherapy with good outcome.
  • Many are benign and can be treated with preservation of the testis.

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  • (PMID = 21520554.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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50. Grichnik JM: Melanoma, nevogenesis, and stem cell biology. J Invest Dermatol; 2008 Oct;128(10):2365-80
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  • [Title] Melanoma, nevogenesis, and stem cell biology.
  • It is now well established that a subpopulation of tumor stem cells (TSCs) are present within cancer tissues.
  • This suggests that tumors evolve from stem cells; however, the exact cell of tumor origin, the potential role of dedifferentiation, and the role of plasticity in tumor development are largely unknown.
  • The developmental biology of melanocytes is relatively well understood, the cells pigment as they differentiate making them easy to identify, and benign and malignant tumors develop on the skin surface allowing direct observation of growth features, early detection, and removal.
  • These TSCs have access to embryologic developmental programs, including the capacity to differentiate along multiple cell lineages.
  • For example, melanomas can activate germ-cell pathways with major implications for TSC self-renewal through the activation of telomerase and genomic instability through the collision of meiotic and mitotic pathways (meiomitosis).
  • The TSC model is still evolving, but the existence of TSCs has significant ramifications for tumor development, diagnosis, prognosis, and treatment of melanoma and other cancers.
  • [MeSH-minor] Animals. Cell Differentiation. Cell Lineage. Cell Proliferation. Genomic Instability. Humans. Meiosis. Melanocytes / pathology


51. Oliveira RM, Verreschi IT, Lipay MV, Eça LP, Guedes AD, Bianco B: Y chromosome in Turner syndrome: review of the literature. Sao Paulo Med J; 2009 Nov;127(6):373-8
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  • The other cases present mosaicism, with a 45,X cell line accompanied by one or more other cell lines with a complete or structurally abnormal X or Y chromosome.
  • Even though gonadoblastoma is a benign tumor, it can undergo transformation into invasive dysgerminoma in 60% of the cases, and also into other, malignant forms of germ cell tumors.

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  • (PMID = 20512293.001).
  • [ISSN] 1806-9460
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Brazil
  • [Number-of-references] 74
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52. Swamy GG, Satyanarayana N: Clinicopathological analysis of ovarian tumors--a study on five years samples. Nepal Med Coll J; 2010 Dec;12(4):221-3
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  • Among 120 cases, majority 86 (71.6%) were benign, but alarming number 30 (25.0%) were malignant, remaining 4 cases were borderline.
  • The commonest benign tumor was serous cyst adenoma, while; the commonest malignant tumors were granulosa cell tumor and endometrial carcinoma.
  • Epithelial tumors were commonest variety of ovarian tumors followed by germ cell tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cystadenoma, Serous / pathology. Epithelium / surgery. Female. Granulosa Cell Tumor / pathology. Humans. Middle Aged. Young Adult

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  • (PMID = 21744762.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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53. Sotomayor P, Godoy A, Smith GJ, Huss WJ: Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate; 2009 Mar 1;69(4):401-10
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  • The stem cell properties of self-renewal and pluripotency in embryonic stem cells and germ cells are regulated by Oct4A, a splice variant of the POU5F1 (Oct3/4) gene, while the function of the alternative splice variant, Oct4B, is unknown.
  • RESULTS: Rare Oct4A expressing cells are present in human benign and malignant prostate glands and the number of Oct4A expressing cells increases in prostate cancers with high Gleason scores.
  • Oct4A expressing cells were non-proliferative, and did not co-express markers of basal epithelial cell or luminal epithelial cell differentiation, or AMACR, a marker of prostate cancer epithelial cells.
  • A subpopulation of the Oct4A expressing cells co-expressed Sox2, an embryonic stem cell marker, but did not express other putative stem cell markers, such as ABCG2, NANOG or CD133.
  • CONCLUSION: The increased number of cells that expressed Oct4A in prostate cancer compared to benign prostate, and in cancers of increasing grade, suggests that Oct4A/Chromogranin A co-expressing cells represent neuroendocrine cells in prostate cancer.

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  • [Copyright] 2008 Wiley-Liss, Inc.
  • [Cites] Am J Surg Pathol. 2007 Jun;31(6):836-45 [17527070.001]
  • [Cites] Cancer Res. 2007 May 15;67(10):4807-15 [17510410.001]
  • [Cites] J Biol Chem. 2007 Jul 20;282(29):21551-60 [17525163.001]
  • [Cites] Eur Urol. 2007 Nov;52(5):1365-73 [17126478.001]
  • [Cites] Endocr Relat Cancer. 2007 Sep;14(3):531-47 [17914087.001]
  • [Cites] Cell. 2007 Nov 30;131(5):861-72 [18035408.001]
  • [Cites] Exp Cell Res. 2008 Jan 1;314(1):92-102 [17900565.001]
  • [Cites] Science. 2007 Dec 21;318(5858):1917-20 [18029452.001]
  • [Cites] Nature. 2008 Jan 10;451(7175):141-6 [18157115.001]
  • [Cites] Cell Stem Cell. 2007 Oct 11;1(4):364-6 [18371374.001]
  • [Cites] Endocr Relat Cancer. 1999 Dec;6(4):503-19 [10730904.001]
  • [Cites] Pathol Res Pract. 2000;196(5):277-84 [10834383.001]
  • [Cites] Stem Cells. 2001;19(4):271-8 [11463946.001]
  • [Cites] Nature. 2001 Nov 1;414(6859):105-11 [11689955.001]
  • [Cites] Ann Oncol. 2001;12 Suppl 2:S159-64 [11762345.001]
  • [Cites] Cancer. 2002 Sep 1;95(5):1028-36 [12209687.001]
  • [Cites] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218.001]
  • [Cites] J Histochem Cytochem. 2003 Jun;51(6):697-706 [12754281.001]
  • [Cites] J Biol Chem. 2004 May 28;279(22):23495-503 [15047715.001]
  • [Cites] Prostate. 2004 Jul 1;60(2):91-7 [15162375.001]
  • [Cites] Cell Tissue Res. 2004 Jun;316(3):369-76 [15127288.001]
  • [Cites] Am J Surg Pathol. 2004 Jul;28(7):935-40 [15223965.001]
  • [Cites] J Cell Sci. 2004 Jul 15;117(Pt 16):3539-45 [15226377.001]
  • [Cites] Prostate Cancer Prostatic Dis. 2004;7(3):188-94 [15289813.001]
  • [Cites] Development. 2004 Oct;131(20):4955-64 [15371309.001]
  • [Cites] Cancer Res. 1988 Apr 15;48(8):1996-2004 [2450643.001]
  • [Cites] Nucleic Acids Res. 1992 Sep 11;20(17):4613-20 [1408763.001]
  • [Cites] Nature. 1994 Feb 17;367(6464):645-8 [7509044.001]
  • [Cites] Mod Pathol. 1995 Aug;8(6):591-8 [8532689.001]
  • [Cites] Mol Cell Biol. 1997 Jan;17(1):154-62 [8972195.001]
  • [Cites] J Urol. 1997 Jul;158(1):171-4 [9186347.001]
  • [Cites] Br J Urol. 1997 Aug;80(2):281-6 [9284203.001]
  • [Cites] Prostate. 1999 May;39(2):135-48 [10221570.001]
  • [Cites] Carcinogenesis. 2005 Feb;26(2):495-502 [15513931.001]
  • [Cites] Am J Pathol. 2005 Feb;166(2):545-55 [15681837.001]
  • [Cites] J Biol Chem. 2005 Feb 25;280(8):6265-8 [15640145.001]
  • [Cites] Cell. 2005 May 6;121(3):465-77 [15882627.001]
  • [Cites] Cancer Res. 2005 Aug 1;65(15):6640-50 [16061644.001]
  • [Cites] Biochem Biophys Res Commun. 2005 Dec 2;337(4):1047-51 [16229821.001]
  • [Cites] Cancer. 2005 Nov 15;104(10):2255-65 [16228988.001]
  • [Cites] Cancer Res. 2005 Dec 1;65(23):10946-51 [16322242.001]
  • [Cites] Endocr Relat Cancer. 2006 Mar;13(1):151-67 [16601285.001]
  • [Cites] Endocr Relat Cancer. 2006 Mar;13(1):181-95 [16601287.001]
  • [Cites] Eur J Cancer. 2006 Jun;42(9):1213-8 [16632344.001]
  • [Cites] Cancer Res. 2006 Sep 1;66(17):8598-607 [16951173.001]
  • [Cites] Prostate. 2006 Sep 15;66(13):1399-406 [16865726.001]
  • [Cites] J Biol Chem. 2006 Nov 3;281(44):33554-65 [16951404.001]
  • [Cites] Biochem Pharmacol. 2006 Nov 30;72(11):1577-88 [16854382.001]
  • [Cites] Stem Cells. 2006 Dec;24(12):2685-91 [16916925.001]
  • [Cites] Mol Carcinog. 2007 Jan;46(1):1-14 [16921491.001]
  • [Cites] Nat Cell Biol. 2007 Jan;9(1):72-9 [17159997.001]
  • [Cites] Nature. 2007 Jan 4;445(7123):111-5 [17122771.001]
  • [Cites] Nature. 2007 Jan 4;445(7123):106-10 [17122772.001]
  • [Cites] Int J Cancer. 2007 Apr 1;120(7):1598-602 [17205510.001]
  • [Cites] Prostate Cancer Prostatic Dis. 2007;10(1):6-14 [17075603.001]
  • [Cites] Mol Vis. 2007;13:823-32 [17615543.001]
  • (PMID = 19058139.001).
  • [ISSN] 1097-0045
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016056; United States / NCI NIH HHS / CA / P01 CA077739-050005; United States / NCI NIH HHS / CA / CA077739-040005; United States / NCI NIH HHS / CA / P01 CA077739; United States / NCI NIH HHS / CA / CA77739; United States / NCI NIH HHS / CA / CA077739-050005; United States / NCI NIH HHS / CA / CA016056; United States / NCI NIH HHS / CA / P01 CA077739-040005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / RNA, Messenger; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / Synaptophysin
  • [Other-IDs] NLM/ NIHMS197155; NLM/ PMC2865184
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54. Rim SY, Kim SM, Choi HS: Struma ovarii showing clinical characteristics of ovarian malignancy. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1156-9
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  • Struma ovarii is a rare form of ovarian neoplasm, composed entirely or predominantly of thyroid tissue and generally a benign germ cell tumor of the ovary.
  • We experienced a rare case of a postmenopausal woman with benign struma ovarii associated with massive ascites, a complex pelvic mass.
  • No recurrence of the ascites or of the tumor has been observed during the 10-month follow-up.
  • [MeSH-major] Biomarkers, Tumor / blood. CA-125 Antigen / blood. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Teratoma / pathology

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  • (PMID = 16343201.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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55. Siekmann AF, Brand M: Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling. Dev Dyn; 2005 Feb;232(2):498-505
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  • Mutations in EXT1 cause hereditary multiple exostoses (HME), benign outgrowths of the bones, and therefore were classed as tumor suppressors.
  • Both ext1a and ext1b are provided maternally and expressed during gastrulation: ext1a in the neurectoderm and ext1b in the embryonic midline and in the involuting mesendoderm of the germ ring.

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  • [Copyright] Copyright 2004 Wiley-Liss, Inc.
  • (PMID = 15614771.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Proteoglycans; 0 / SHH protein, human; 0 / Trans-Activators; 0 / Zebrafish Proteins; 63231-63-0 / RNA; EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1
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56. Schultz KA, Sencer SF, Messinger Y, Neglia JP, Steiner ME: Pediatric ovarian tumors: a review of 67 cases. Pediatr Blood Cancer; 2005 Feb;44(2):167-73
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  • RESULTS: Thirty patients had benign tumors.
  • Thirty-seven patients had malignant tumors: 11 immature teratomas, seven malignant mixed germ cell tumors, seven juvenile granulosa cell tumors, five dysgerminomas, two endodermal sinus tumors, two serous papillary cystadenocarcinomas, one small cell carcinoma, one anaplastic sex-cord tumor, and one undifferentiated sarcoma.
  • Torsion was seen more often in patients with benign tumors (23 vs. 8%); two patients had both torsion and acute appendicitis.
  • The neoplasm was an incidental finding in 12 patients.
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / blood. Child. Child, Preschool. Chromosome Aberrations. Female. Humans. Infant. Infant, Newborn. Neoplasm Metastasis

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  • (PMID = 15490488.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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57. Bahrami A, Ro JY, Ayala AG: An overview of testicular germ cell tumors. Arch Pathol Lab Med; 2007 Aug;131(8):1267-80
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  • [Title] An overview of testicular germ cell tumors.
  • CONTEXT: More than 90% of testicular neoplasms originate from germ cells.
  • Testicular germ cell tumors (GCTs) are a heterogeneous group of neoplasms with diverse histopathology and clinical behavior.
  • Unclassified intratubular germ cell neoplasia is the precursor of all GCTs, excluding spermatocytic seminoma and infantile/prepubertal GCTs.
  • Spermatocytic seminoma, a tumor of elderly men, typically has an indolent clinical behavior, but rarely it undergoes sarcomatous transformation associated with an aggressive behavior.
  • Most patients with prepubertal yolk sac tumor, the most common pediatric GCT, have stage I disease at presentation.
  • Teratomas in children regardless of maturity and dermoid cysts in adults are benign; in contrast, teratomas in adults have a malignant behavior.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Male. Prognosis. World Health Organization

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  • (PMID = 17683189.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 154
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58. Albert A, Tarrado X, Montaner A, Cáceres F, Parareda A, Cruz O, Mora J, Morales L: [The role of surgery for lung nodules in pediatric oncology]. Cir Pediatr; 2006 Oct;19(4):228-31
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  • The primary pathological diagnoses include: Osteosarcoma n = 17, Ewing's sarcoma n = 14, Rhabdomyosarcoma n = 5, Germ cell tumor n = 4, other sarcomas n = 4, Wilms' tumor n = 3, Neuroblastoma n = 3, Lymphoma n = 2.
  • Among the nine, five showed either normal lung tissue or scarring after tumor necrosis, and four had other benign diagnoses including: reactive inflammatory cells, pleural lymphangioma, mycobacteria infection and inflammatory pseudotumor.

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  • (PMID = 17352112.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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59. McCarthy JD, Erickson KM, Smith YR, Quint EH: Premenarchal ovarian torsion and elevated CA-125. J Pediatr Adolesc Gynecol; 2010 Feb;23(1):e47-50
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  • BACKGROUND: Ovarian tumors are the most common gynecologic malignancy occurring in childhood, with germ cell tumors being most frequent.
  • Tumor markers are an integral part of the work-up and may guide management.
  • Other tumor markers were normal.
  • This benign finding allowed attempting a conservative ovary-sparing approach during the surgery even in the presence of a highly elevated CA-125.

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  • [Copyright] Copyright 2010 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.
  • [Cites] J Pediatr Adolesc Gynecol. 1999 Feb;12(1):27-9 [9929837.001]
  • [Cites] Semin Pediatr Surg. 2005 May;14(2):86-92 [15846564.001]
  • [Cites] Obstet Gynecol. 2005 Jun;105(6):1405-9 [15932836.001]
  • [Cites] Arch Gynecol Obstet. 2007 Nov;276(5):559-61 [17497163.001]
  • [Cites] J Pediatr Surg. 2000 Aug;35(8):1248-51 [10945705.001]
  • [Cites] Obstet Gynecol. 2000 Aug;96(2):229-33 [10908768.001]
  • [Cites] Ann Intern Med. 1994 Jul 15;121(2):124-32 [8017726.001]
  • [Cites] J Pediatr Surg. 1993 Jul;28(7):930-3 [8229571.001]
  • (PMID = 19589703.001).
  • [ISSN] 1873-4332
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD059353-01; United States / NICHD NIH HHS / HD / L50 HD059353-01
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-125 Antigen
  • [Other-IDs] NLM/ NIHMS130831; NLM/ PMC2818042
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60. López Almaraz R, Villafruela Alvarez C, Rodríguez Luis J, Doménech Martínez E: [Neonatal neoplasms: a single-centre experience]. An Pediatr (Barc); 2006 Dec;65(6):529-35
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  • INTRODUCTION: Malignant tumors are uncommon in the neonatal period and benign tumors may have malignant potential.
  • The variables analyzed were the percentage of neonatal neoplasms among the total number of cancer cases in children aged less than 14 years, their incidence among all the newborns in our hospital, sex, year of diagnosis, age at clinical diagnosis, the presence or absence of prenatal diagnosis, type of tumor (histologic diagnosis), association with syndromes or other congenital anomalies, treatment, and long-term outcome.
  • Histologic diagnoses were neuroblastoma (n = 5; 31.2 %), teratoma/ germ cell tumor (n = 4; 25 %), soft tissue sarcoma (one fibrosarcoma of the thigh and two hemangiopericytoma of the back and heart; 18.8 %), and one case each of mesoblastic nephroma, cerebral tumor (ependymoblastoma), melanoma (associated with giant congenital melanocytic nevi), and acute leukemia (associated with Down syndrome).
  • CONCLUSIONS: The neoplasms most frequently diagnosed in the neonatal period were solid tumors, mainly neuroblastoma and teratomas/germ cell tumors; 12.5 % were associated with syndromes or congenital anomalies.

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  • [CommentIn] An Pediatr (Barc). 2007 Jul;67(1):85-6 [17663916.001]
  • (PMID = 17194321.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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61. Ulbright TM: Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Mod Pathol; 2005 Feb;18 Suppl 2:S61-79
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  • [Title] Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
  • Gonadal germ cell tumors continue to be the cause of diverse, diagnostically challenging issues for the pathologist, and their correct resolution often has major important therapeutic and prognostic implications.
  • Within the teratoma group, there is strong evidence that ovarian and prepubertal testicular teratomas are derived from benign germ cells, a pathogenesis that likely applies also to the rare dermoid cysts and uncommon epidermoid cysts of the testis.
  • In contrast, postpubertal testicular teratomas derive from malignant germ cells, specifically representing differentiation within a preexistent nonteratomatous cancer.
  • As expected, given the foregoing, teratomas in boys are clinically benign, whereas in postpubertal males they are malignant, independent of their degree of immaturity.
  • When uncommon somatic-type malignancies (usually squamous cell carcinoma) occur in mature cystic teratomas of the ovary, this is a de novo form of malignant transformation; similar tumors in the testis, a very rare event, represent overgrowth of teratomatous elements that originated from malignant, nonteratomatous germ cell tumors and, therefore, had previously undergone malignant transformation.
  • Germinomas may have several unusual features in each gonad; these include microcystic arrangements that suggest yolk sac tumor, tubular patterns that mimic Sertoli cell tumor, apparent increased cytological atypia that causes concern for embryonal carcinoma, and prominent syncytiotrophoblast giant cells that suggest choriocarcinoma.
  • A newly recognized aspect of this tumor is the propensity for some to be relatively monomorphic, making them apt to be mistaken for usual seminoma or embryonal carcinoma, although the characteristic polymorphic appearance in some foci, absence of intratubular germ cell neoplasia, unclassified type, and immunohistochemical stains should prevent this error.
  • Yolk sac tumor continues to be confused occasionally with clear cell carcinoma of the ovary.
  • The usually younger age of patients with yolk sac tumors helps with the differential considerations with the nongerm cell tumors, as do other clinical and microscopic features and selected immunohistochemical stains.
  • Syncytiotrophoblast cells alone, admixed with other forms of germ cell tumor, still are confused with choriocarcinoma, but this phenomenon, which is much more frequent than choriocarcinoma, lacks the plexiform arrangement of different trophoblast cell types that typifies the latter.
  • Mixed germ cell tumors (which may show almost any combination of components) are common in the testis but rare in the ovary.
  • A separately categorized, rare form of mixed germ cell tumor seen in both gonads is the polyembryoma.
  • It is perhaps the most photogenic of all gonadal germ cell tumors and is also intriguing because of its distinctive, organized arrangement of yolk sac tumor and embryonal carcinoma elements and recapitulation of very early embryonic development, even to the extent of having in its fundamental unit, the embryoid body, a miniature yolk sac, and amniotic cavity.
  • Embryoid bodies are also common as a minor component of many mixed germ cell tumors, particularly in the testis, and the diffuse embryoma is another variant that has a particular arrangement of yolk sac tumor and embryonal carcinoma elements.
  • Regression of gonadal germ cell tumors is a phenomenon restricted to the testis, for unknown reasons.
  • These so-called 'burnt-out' germ cell tumors can be recognized by a distinctive constellation of findings, including sometimes minor foci of residual recognizable germ cell neoplasia, a well-defined zone of scarring (often having residual ghost tubules), associated lymphoplasmacytic infiltrate, intratubular calcification and, in about 50%, of in situ germ cell neoplasia.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Ovarian Neoplasms / pathology. Testicular Neoplasms / pathology

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  • (PMID = 15761467.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Organic Cation Transport Proteins; 0 / solute carrier family 22 (organic cation transporter), member 3; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 132
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62. Merchant A, Stewart RW: Sacrococcygeal yolk sac tumor presenting as subcutaneous fluid collection initially treated as abscess. South Med J; 2010 Oct;103(10):1068-70
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  • [Title] Sacrococcygeal yolk sac tumor presenting as subcutaneous fluid collection initially treated as abscess.
  • Malignant extragonadal germ cell tumors, though more common in infants and children, are rare.
  • We report a case of an 11-month-old female with sacrococcygeal extragonadal yolk sac tumor manifesting as a draining subcutaneous nodule after initial treatment as an abscess.
  • Extragonadal germ cell tumors can present with external manifestations confusingly similar to other more benign soft tissue conditions.
  • [MeSH-major] Abscess / diagnosis. Endodermal Sinus Tumor / diagnosis. Sacrococcygeal Region

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  • (PMID = 20818302.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Mitra AV, Jameson C, Barbachano Y, Sodha N, Kote-Jarai Z, Javed A, Bancroft E, Fletcher A, Cooper C, Peock S, IMPACT and EMBRACE Collaborators, Easton D, Eeles R, Foster CS: Elevated expression of Ki-67 identifies aggressive prostate cancers but does not distinguish BRCA1 or BRCA2 mutation carriers. Oncol Rep; 2010 Feb;23(2):299-305
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  • This study was performed to test the hypothesis that enhanced expression of Ki-67, as a surrogate of cell proliferation, is a characteristic feature of prostate cancers occurring in BRCA1 or BRCA2 mutation carriers.
  • Of the combined sample cohort, 65.7% stained only within malignant tissues while 0.7% stained in both malignant and benign tissues (p<0.001).
  • While all prostate cancers occurring in the presence of BRCA germline mutations are clinically aggressive, their potentially different phenotypes consistently involve maximal rates of cell proliferation.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor. Cell Proliferation. Germ-Line Mutation. Heterozygote Detection / methods. Humans. Male. Middle Aged. Neoplasm Invasiveness. Up-Regulation

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  • (PMID = 20043088.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / 10118; United Kingdom / Medical Research Council / / G0802851; United Kingdom / Cancer Research UK / / C5047/A7357
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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64. Hoekzema R, Zonneveld IM, van der Wal AC: Type 2 segmental glomangiomas. Dermatol Online J; 2010;16(1):8
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  • Glomangiomas of the skin, currently named glomuvenous malformations (GVMs), are benign vascular lesions composed of thin-walled distorted blood vessels, surrounded by variable rows of glomus cells.
  • Glomuvenous malformations occur after both alleles of the gene encoding for glomulin, a molecule involved in smooth muscle cell differentiation, are hit by a loss-of-function mutation.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Glomus Tumor / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Germ-Line Mutation. Humans. Loss of Heterozygosity. Male. Myocytes, Smooth Muscle / pathology. Thigh. Thorax. Wrist

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  • (PMID = 20137750.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / GLMN protein, human
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65. De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW: Ovarian germ cell tumors in children: a clinical study of 66 patients. Pediatr Blood Cancer; 2006 Apr;46(4):459-64
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  • [Title] Ovarian germ cell tumors in children: a clinical study of 66 patients.
  • BACKGROUND: Ovarian germ cell tumors are rare in childhood.
  • The aim of this study is to review clinical presentation, management, and outcome in a two-center series of girls with ovarian germ cell tumor.
  • PROCEDURE: The records of 66 patients (median age 9 years) with histologically proven ovarian germ cell tumor (either benign or malignant), treated over a 44-year-span, were reviewed.
  • Sixteen patients had an emergency operation for tumor torsion.
  • Surgical removal of the tumor with or without the ovary and/or adnex was the sole treatment in 55 patients, chemotherapy was administered in 10 and radiotherapy + chemotherapy in one.
  • CONCLUSIONS: With a recurrence rate of 4.5% and a mortality rate of 3%, this series confirms the excellent prognosis for girls with ovarian germ cell tumor (GCT).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Germ Cell and Embryonal / drug therapy. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16206211.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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66. Dalloul M, Sherer DM, Gorelick C, Serur E, Zinn H, Sanmugarajah J, Zigalo A, Abulafia O: Transient bilateral ovarian enlargement associated with large retroperitoneal lymphoma. Ultrasound Obstet Gynecol; 2007 Feb;29(2):236-8
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  • Bilateral ovarian enlargement may reflect benign or malignant processes of the ovary.
  • Benign causes of ovarian enlargement include luteomas, tumors such as mature cystic teratomas, fibrothecomas, cystadenomas and rare conditions including capillary hemangioma and massive edema of the ovaries.
  • Ovarian malignancies include epithelial, stromal and germ-cell tumors.
  • Subsequent computerized tomography (CT) imaging depicted a large retroperitoneal tumor, CT-guided biopsy of which revealed diffuse large B cell lymphoma.
  • The patient responded well to chemotherapy with significant shrinkage of the tumor, and reappearance of normal findings on ovarian sonography.
  • This case demonstrates that bilaterally enlarged ovaries may be the first clinical evidence of a large retroperitoneal tumor and that in such cases CT imaging may be warranted.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Ovarian Neoplasms / pathology. Ovary / pathology. Retroperitoneal Neoplasms / pathology

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  • [Copyright] Copyright 2007 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 17252529.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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67. Wang WP, Guo C, Berney DM, Ulbright TM, Hansel DE, Shen R, Ali T, Epstein JI: Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2010 Apr;34(4):519-24
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  • All 29 primary carcinoids lacked associated intratubular germ cell neoplasia, unclassified type.
  • Of the 4 patients with a primary atypical carcinoid tumor, 1 at the time of diagnosis had retroperitoneal and lung metastases who after chemotherapy underwent resection of the retroperitoneal tumor showing metastatic yolk sac tumor and embryonal carcinoma.
  • Most primary carcinoid tumors of the testis have a benign clinical course even if associated with epidermoid/dermoid cysts, or histologically mature teratoma.
  • [MeSH-major] Carcinoid Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Nucleus / pathology. Child. Humans. Male. Middle Aged. Mitosis. Orchiectomy. Young Adult. alpha-Fetoproteins / analysis

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  • [ErratumIn] Am J Surg Pathol. 2010 Jul;34(7):1075. Ubright, Thomas M [corrected to Ulbright, Thomas M]
  • (PMID = 20351489.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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68. Camparo P, Durand X, Avances C, Culine S, Segui B, Rigaud J, Membres du GELU-Groupe d'Etude des Lésions Urologiques, Membres du CCAFU: [Histological features and principles of treating testicle tumors in the elderly subject]. Prog Urol; 2009 Nov;19 Suppl 3:S142-6
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  • Germ cell tumors, mainly seminomas, represent less than 20% cases.
  • Therapy do not differ from young adults germ cell tumors.
  • Sex cord stromal tumors, mesenchymal benign tumors, sarcomas and metastasis represent approximately 10% of cases each.
  • The one of metastasis depends on primitive tumor (prostatic or pulmonary adenocarcinoma or melanoma mainly).
  • Spermatocytic seminoma is a rare and benign tumor, if no sarcomatous component is observed.

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  • [Copyright] (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20123499.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Investigator] Choudat L; Priollet BC; Comperat E; Sibony M; Vassiliu V; Verkarre V; Allory Y; Ferlicot S; Molinié V; Denoux Y; Sautet A; Lesourd A; Trillet M; Petit T; Aillet G; Vieillefond A; Boccon-Gibod L
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69. Singalavanija S, Limpongsanurak W: Cutaneous mastocytosis in Thai children. J Med Assoc Thai; 2008 Oct;91 Suppl 3:S143-6
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  • Most of the children were healthy, except the one who had germ cell ovarian tumor Skin biopsies were performed in all cases and revealed mast cells infiltrate in the dermis.
  • Oral mast cell stabilizers were given in 6 patients (12%) and topical corticosteroids in 15 patients (30%).
  • CONCLUSION: Cutaneous mastocytosis is a benign disease in children without systemic involvement.

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  • (PMID = 19253510.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Histamine Antagonists; 9PHQ9Y1OLM / Prednisolone
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70. Tucci G, Muzi MG, Nigro C, Cadeddu F, Amabile D, Servadei F, Farinon AM: Dermoid cyst of the pancreas: presentation and management. World J Surg Oncol; 2007;5:85
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  • BACKGROUND: Dermoid cyst of the pancreas is a benign, well-differentiated, extremely rare germ cell neoplasm.
  • Computerized Tomography (CT) showed a 5 cm cystic tumor arising from pancreatic tail and Magnetic Resonance Imaging (MRI) suggested a tumor extension to the middle side of the stomach without defined margins.
  • CONCLUSION: Given the benign nature of the dermoid cyst, surgical resection most likely represents the definitive treatment and cure.

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  • [Cites] Semin Diagn Pathol. 2000 Feb;17(1):56-65 [10721807.001]
  • [Cites] JOP. 2006;7(6):643-6 [17095845.001]
  • [Cites] Mod Pathol. 2002 May;15(5):492-501 [12011254.001]
  • [Cites] Gastrointest Endosc. 2003 Nov;58(5):690-5 [14595302.001]
  • [Cites] Ann Saudi Med. 2004 May-Jun;24(3):206-9 [15307462.001]
  • [Cites] Vestn Khir Im I I Grek. 1972 Mar;107(3):124 [5027996.001]
  • [Cites] Vestn Khir Im I I Grek. 1973 Apr;110(4):92-3 [4712370.001]
  • [Cites] Am Surg. 1977 Aug;43(8):503-4 [889185.001]
  • [Cites] Arq Gastroenterol. 1984 Oct-Dec;21(4):183-6 [6536257.001]
  • [Cites] Radiology. 1987 Feb;162(2):431-3 [3541031.001]
  • [Cites] Chirurg. 1990 Jul;61(7):548-9 [2203644.001]
  • [Cites] Arch Surg. 1990 Sep;125(9):1215-8 [2205176.001]
  • [Cites] Gastroenterol Clin Biol. 1990;14(12):1023-5 [2289662.001]
  • [Cites] Ann Surg. 1992 Feb;215(2):132-9 [1546898.001]
  • [Cites] AJR Am J Roentgenol. 1993 Mar;160(3):523-4 [8430545.001]
  • [Cites] Diagn Cytopathol. 1993;9(1):66-9 [8458286.001]
  • [Cites] Eur J Surg. 1993 Aug;159(8):437-9 [8105979.001]
  • [Cites] Int J Pancreatol. 1993 Dec;14(3):269-73 [7906703.001]
  • [Cites] Hepatogastroenterology. 1998 Sep-Oct;45(23):1874-6 [9840167.001]
  • [Cites] Ann Surg. 1999 Aug;230(2):152-61 [10450728.001]
  • [Cites] Anticancer Res. 1999 Jul-Aug;19(4A):2717-20 [10470227.001]
  • [Cites] Pol Tyg Lek (Wars). 1956 Oct 1;11(40):1710-3 [13388866.001]
  • [Cites] Gastrointest Endosc. 2005 Jun;61(7):854-61 [15933687.001]
  • [Cites] J Hepatobiliary Pancreat Surg. 2005;12(4):336-40 [16133705.001]
  • [Cites] Gastrointest Endosc Clin N Am. 2000 Oct;10(4):619-36, vi [11036536.001]
  • (PMID = 17683548.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC1952065
  • [General-notes] NLM/ Original DateCompleted: 20070828
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71. Ueno S, Hirakawa H, Matsuda H, Tei E, Kaneko A, Ohta Y, Kajiwara H: A case of neonatal mature teratoma transformed to malignancy in the neck extending to the mouth floor. Tokai J Exp Clin Med; 2009 Dec;34(4):130-4
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  • Puncture and marsupialisation of the cyst could not relieve her symptom and the tumor was resected in three occasions and was diagnosed as mature teratoma without malignant component.
  • Biopsied specimen demonstrated the mass to be germ cell tumor with embryonal carcinoma and yolk sac tumor component.
  • Head and neck teratomas in children are mostly benign amenable to curative excision but its rarity and site and size of the tumor make its treatment challenging.
  • There exists a relationship between the age at diagnosis and outcome of a patient with teratoma and head and neck teratomas in neonate are mostly benign but should be removed completely as soon as the patient condition is stabilized to reduce the risk of malignant change.
  • [MeSH-major] Cell Transformation, Neoplastic. Head and Neck Neoplasms / secondary. Mouth Floor / pathology. Mouth Neoplasms / secondary. Teratoma / pathology

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  • (PMID = 21319013.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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72. Veras E, Deavers MT, Silva EG, Malpica A: Ovarian nonsmall cell neuroendocrine carcinoma: a clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol; 2007 May;31(5):774-82
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  • [Title] Ovarian nonsmall cell neuroendocrine carcinoma: a clinicopathologic and immunohistochemical study of 11 cases.
  • Nonsmall cell neuroendocrine carcinoma (NSCNEC) of the ovary is a rare and aggressive tumor commonly associated with other surface epithelial and germ cell neoplasms.
  • In 2 cases, the tumor was associated with a mature cystic teratoma; one of them also containing an invasive moderately differentiated adenocarcinoma.
  • A single case was associated with a benign ovarian cyst.
  • NSCNEC represented anywhere from 10% to 90% of the ovarian tumor.
  • In summary, ovarian NSCNEC is an aggressive tumor with a tendency to present at advanced stage and cause death within a mean of 17 months after diagnosis; however, some patients, particularly those with stage I disease and/or those who have received platinum-based therapy, may have a more favorable prognosis.
  • [MeSH-major] Biomarkers, Tumor. Carcinoma, Neuroendocrine / pathology. Immunoenzyme Techniques. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Proteins / analysis. Neoplasm Staging. Neoplasms, Multiple Primary. Remission Induction. Treatment Outcome

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  • (PMID = 17460463.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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73. Khonsari RH: [Jaw tumors of embryonic origin]. Rev Stomatol Chir Maxillofac; 2009 Sep;110(4):214-6
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  • The term jaw tumor of embryonic origin includes vestiges of organogenetic processes, hamartomas, teratomas, and blastemal tumors.
  • Oral cavity teratomas are almost always mature and thus benign and encapsulated.
  • It can be immediate postbirth tumor removal when neonatal respiratory distress can be managed by the anesthesiologist, or an EXIT (ex utero intrapartum) procedure.
  • [MeSH-major] Jaw Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis

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  • (PMID = 19647282.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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74. Jha R, Karki S: Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J; 2008 Jun;10(2):81-5
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  • A female's risk at birth of having ovarian tumor sometime in her life is 6-7%.
  • Relative frequency of ovarian tumor is different for western and Asian countries.
  • One hundred and thirty five of these tumors (83.9%) were benign and 16.1% (26/161) were malignant.
  • Surface epithelial tumors were most common (52.2%) followed by germ cell tumors (42.2%).
  • Mature cystic teratoma was commonest benign tumor (48.2%).
  • Serous adenocarcinoma was commonest malignant tumor (46.2%).
  • For all age groups, benign tumors were more common than malignant ones.
  • In 1st two decades, germ cell tumors were more common than other tumors.

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  • (PMID = 18828427.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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75. Datiashvili RO, Izadi K, Centurion SA, Lambert WC, Scarpidis U: Malignant melanocytic trichoblastoma. Ann Plast Surg; 2006 Feb;56(2):208-10
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  • Trichoblastoma is an uncommon benign cutaneous neoplasm of the hair germ cell.
  • The pigmented variety of the tumor is rare.
  • We are presenting a case report of a 47-year-old patient with malignant trichoblastoma containing melanin deposits and propose to define this variety of the tumor as a separate entity: malignant melanocytic trichoblastoma.

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  • (PMID = 16432335.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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76. Hinz S, Magheli A, Weikert S, Schulze W, Krause H, Schrader M, Miller K, Kempkensteffen C: Deregulation of EZH2 expression in human spermatogenic disorders and testicular germ cell tumors. World J Urol; 2010 Oct;28(5):631-5
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  • [Title] Deregulation of EZH2 expression in human spermatogenic disorders and testicular germ cell tumors.
  • INTRODUCTION: Enhancer of Zeste 2 (EZH2) is an epigenetic transcriptional repressor involved in cell cycle control and cell fate decisions.
  • Since these processes play key roles during intact spermatogenesis, deregulation of EZH2 expression may contribute to the development and progression of benign and malignant testicular diseases.
  • The objective of this study was to investigate the expression profile of EZH2 in testicular germ cell tumors (TGCT) and spermatogenic defects.
  • EZH2 tumor levels were not related to the histological TGCT subtype or clinical tumor stage.
  • [MeSH-major] Biomarkers, Tumor / metabolism. DNA-Binding Proteins / metabolism. Down-Regulation / physiology. Neoplasms, Germ Cell and Embryonal / metabolism. Spermatogenesis / physiology. Testicular Neoplasms / metabolism. Transcription Factors / metabolism

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  • [Cites] Biochim Biophys Acta. 2002 Jun 21;1602(2):151-61 [12020801.001]
  • [Cites] Int J Androl. 2004 Jun;27(3):161-5 [15139971.001]
  • [Cites] Hum Reprod. 1998 May;13(5):1230-4 [9647552.001]
  • [Cites] J Cell Biochem Suppl. 2001;Suppl 36:129-43 [11455578.001]
  • [Cites] Cell. 2003 Mar 7;112(5):599-606 [12628181.001]
  • [Cites] J Androl. 2007 Jul-Aug;28(4):466-80 [17287457.001]
  • [Cites] Stem Cells. 2007 Sep;25(9):2191-9 [17525233.001]
  • [Cites] Int J Androl. 2005 Aug;28(4):224-9 [16048634.001]
  • [Cites] J Clin Oncol. 2006 Jan 10;24(2):268-73 [16330673.001]
  • [Cites] J Cancer Res Clin Oncol. 2008 Mar;134(3):331-6 [17694325.001]
  • [Cites] Mol Hum Reprod. 2007 Jan;13(1):33-43 [17114209.001]
  • [Cites] J Immunol. 2001 May 15;166(10 ):5925-34 [11342607.001]
  • [Cites] Cell. 2006 Apr 21;125(2):301-13 [16630818.001]
  • [Cites] Nature. 2002 Oct 10;419(6907):624-9 [12374981.001]
  • [Cites] J Pathol. 2008 Jun;215(2):175-83 [18393368.001]
  • [Cites] Hum Reprod. 1999 Sep;14 Suppl 1:82-96 [10573026.001]
  • [Cites] J Cell Physiol. 2008 Feb;214(2):295-300 [17786943.001]
  • [Cites] Cancer Res. 2000 Mar 15;60(6):1475-82 [10749107.001]
  • [Cites] Mutat Res. 2008 Dec 1;647(1-2):21-9 [18723033.001]
  • [Cites] Neoplasia. 2005 Nov;7(11):1011-9 [16331887.001]
  • [Cites] EMBO J. 2003 Oct 15;22(20):5323-35 [14532106.001]
  • (PMID = 20043168.001).
  • [ISSN] 1433-8726
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Enhancer of Zeste Homolog 2 Protein; EC 2.1.1.43 / Polycomb Repressive Complex 2
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77. Behtash N, Karimi Zarchi M: Placental site trophoblastic tumor. J Cancer Res Clin Oncol; 2008 Jan;134(1):1-6
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  • [Title] Placental site trophoblastic tumor.
  • Placental site trophoblastic tumor (PSTT) is a rare neoplasm that rises from intermediate trophoblasts and commonly presents with low and variable concentration of HCG immunoactivity in serum, which can be difficult to differentiate from early stage choriocarcinoma/gestational trophoblastic neoplasm (GTN) or quiescent gestational trophoblastic disease.
  • There is a wide clinical spectrum of presentation and behavior ranging from a benign condition to an aggressive disease with fatal outcome.
  • Nontrophoblastic malignancies such as germ cell tumors or other tumors secreting low HCG must also be considered in the differential diagnosis.
  • [MeSH-major] Trophoblastic Tumor, Placental Site / pathology. Uterine Neoplasms / pathology

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  • [Cites] Gynecol Oncol. 2004 Feb;92(2):708-12 [14766272.001]
  • [Cites] Gynecol Oncol. 1999 May;73(2):216-22 [10329037.001]
  • [Cites] Cancer. 2002 Apr 15;94(8):2288-94 [12001129.001]
  • [Cites] Gynecol Oncol. 1988 Sep;31(1):32-42 [2842238.001]
  • [Cites] Gynecol Oncol. 2000 Jan;76(1):115-7 [10620452.001]
  • [Cites] Int J Gynecol Cancer. 2004 May-Jun;14 (3):558-63 [15228435.001]
  • [Cites] Hum Pathol. 1993 Oct;24(10):1098-106 [7691711.001]
  • [Cites] Med Pediatr Oncol. 2002 Mar;38(3):187-91; discussion 192 [11836719.001]
  • [Cites] Gynecol Oncol. 2001 Sep;82(3):415-9 [11520134.001]
  • [Cites] Clin Cancer Res. 1996 May;2(5):897-902 [9816247.001]
  • [Cites] Radiat Med. 1999 Nov-Dec;17 (6):427-30 [10646979.001]
  • [Cites] Obstet Gynecol Surv. 2003 Jul;58(7):484-8 [12832940.001]
  • [Cites] Hum Pathol. 1985 Jan;16(1):35-42 [2982714.001]
  • [Cites] Hum Pathol. 1998 Mar;29(3):280-8 [9496832.001]
  • [Cites] Lab Invest. 2000 Jun;80(6):965-72 [10879746.001]
  • [Cites] Gynecol Oncol. 1981 Oct;12(2 Pt 1):238-48 [6271654.001]
  • [Cites] World J Surg Oncol. 2005 Jun 15;3(1):34 [15958158.001]
  • [Cites] Gynecol Oncol. 1998 Jan;68(1):62-5 [9454662.001]
  • [Cites] J Reprod Med. 1998 Jan;43(1):37-43 [9475148.001]
  • [Cites] Histopathology. 1982 Mar;6(2):211-26 [6281156.001]
  • [Cites] Hum Pathol. 1998 Jan;29(1):27-33 [9445130.001]
  • [Cites] J Reprod Med. 2004 Jun;49(6):447-52 [15283052.001]
  • [Cites] APMIS Suppl. 1991;23:138-45 [1652995.001]
  • [Cites] Obstet Gynecol. 1985 Apr;65(4):527-34 [2984618.001]
  • [Cites] Hum Pathol. 1997 Nov;28(11):1302-6 [9385938.001]
  • [Cites] Placenta. 1984 Jul-Aug;5(4):349-69 [6209706.001]
  • [Cites] J Reprod Med. 2002 Jun;47(6):460-4 [12092014.001]
  • [Cites] Gynecol Oncol. 2006 Aug;102(2):160-4 [16631918.001]
  • [Cites] Hum Pathol. 1991 Sep;22(9):847-55 [1655617.001]
  • [Cites] Pathol Oncol Res. 2000;6(4):292-4 [11173663.001]
  • [Cites] Eur J Gynaecol Oncol. 2003;24(1):25-9 [12691312.001]
  • [Cites] Br J Cancer. 1992 Mar;65(3):355-8 [1348423.001]
  • [Cites] Cancer. 1976 Sep;38(3):1214-26 [182351.001]
  • [Cites] Gynecol Oncol. 2002 Dec;87(3):303-7 [12468329.001]
  • [Cites] Int J Gynecol Cancer. 1995 Jul;5(4):241-249 [11578484.001]
  • [Cites] Obstet Gynecol. 1985 Sep;66(3 Suppl):95S-100S [2991836.001]
  • [Cites] Acta Cytol. 1998 May-Jun;42(3):745-50 [9622699.001]
  • [Cites] Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:445-8 [16515643.001]
  • [Cites] J Reprod Med. 1998 Jan;43(1):53-9 [9475150.001]
  • [Cites] J Clin Oncol. 2000 Feb;18(4):854-9 [10673528.001]
  • [Cites] Int J Gynecol Cancer. 2004 Sep-Oct;14(5):980-3 [15361212.001]
  • (PMID = 17701427.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 48
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78. Salemi M, Calogero AE, Vicari E, Migliore E, Zaccarello G, Cosentino A, Amore M, Tricoli D, Castiglione R, Bosco P, Rappazzo G: A high percentage of skin melanoma cells expresses SPANX proteins. Am J Dermatopathol; 2009 Apr;31(2):182-6
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  • The expression of SPANX (sperm protein associated with the nucleus in the X chromosome) gene family has been reported in many tumors, such as melanoma, myeloma, glioblastoma, breast carcinoma, ovarian cancer, testicular germ cell tumors, and hematological malignancies.
  • The expression of SPANX proteins was evaluated by immunohistochemistry in normal skin (n = 12), melanomas (n = 21), and benign nevi (n = 10), using a polyclonal antibody raised in our laboratory.
  • Benign nevi had an intermediate number of cells expressing SPANX proteins (25% +/- 8.5%), which resulted significantly higher than normal skin cells and significantly lower than skin melanoma cells.
  • In melanoma cells, the labeling was mostly nuclear, sometimes incomplete or limited to the perinuclear wall, even if cytoplasmic staining was also seen in SPANX-positive tumor cells.

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  • (PMID = 19318807.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Epitopes; 0 / Nuclear Proteins; 0 / SPANXA1 protein, human
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79. Devouassoux-Shisheboran M, Deschildre C, Mauduit C, Berger G, Mejean-Lebreton F, Bouvier R, Droz JP, Fénichel P, Benahmed M: Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors. Oncol Rep; 2006 Aug;16(2):335-40
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  • [Title] Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors.
  • The aim of our study was to investigate galectin-3 mRNA and protein expression in normal ovaries and testes as well as in a variety of 51 gonadal sex cord stromal and germ cell tumors, and two testicular seminomatous and non-seminomatous cell lines, using either real-time PCR or immunohistochemistry.
  • In human ovaries, galectin-3 is absent from granulosa cells, as well as from granulosa cell and Sertoli-Leydig cell tumors, and is not a useful marker in distinguishing granulosa cell from Sertoli-Leydig cell tumors.
  • In malignant testicular Sertoli cell tumors, the expression of galectin-3 is down-regulated while, in benign Leydig cell tumors, this expression is maintained, indicating the possible implication of this gene in the development of more aggressive testicular sex cord stromal tumors.
  • In contrast to sex cord stromal tumors, galectin-3 expression is up-regulated in testicular germ cell tumors.
  • By real-time PCR, we demonstrated a significant elevation of the galectin-3 mRNA level in non-seminomatous testicular germ cell tumors and cell line as compared to normal testes and seminomas (p=0.0432 and p=0.0247, respectively), indicating the possible role of this gene in the non-seminomatous differentiation of germ cell tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Galectin 3 / analysis. Sertoli Cell Tumor / diagnosis. Sex Cord-Gonadal Stromal Tumors / diagnosis. Testicular Neoplasms / diagnosis

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  • (PMID = 16820912.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / RNA, Messenger; 0 / Receptors, Androgen
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80. Ciotti P, Garuti A, Gulli R, Ballestrero A, Bellone E, Mandich P: Germline mutations in the von Hippel-Lindau gene in Italian patients. Eur J Med Genet; 2009 Sep-Oct;52(5):311-4
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  • von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumours, most frequently retinal, cerebellar, and spinal hemangioblastoma, renal cell carcinoma, pheochromocytoma, and pancreatic tumours.
  • [MeSH-major] Genes. Germ-Line Mutation. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics

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  • (PMID = 19464396.001).
  • [ISSN] 1878-0849
  • [Journal-full-title] European journal of medical genetics
  • [ISO-abbreviation] Eur J Med Genet
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9007-49-2 / DNA; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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81. Biesheuvel CJ, Vergouwe Y, Steyerberg EW, Grobbee DE, Moons KG: Polytomous logistic regression analysis could be applied more often in diagnostic research. J Clin Epidemiol; 2008 Feb;61(2):125-34
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  • STUDY DESIGN AND SETTING: We used data from a study on the diagnosis of residual retroperitoneal mass histology in patients presenting with nonseminomatous testicular germ cell tumor.
  • The differential diagnoses include benign tissue, mature teratoma, and viable cancer.
  • The ROC areas for benign tissue, mature teratoma, and viable cancer were similar for both modeling methods, 0.83 (95% confidence interval [CI]=0.80-0.85) vs. 0.83 (95% CI=0.80-0.85), 0.78 (95% CI=0.75-0.81) vs. 0.78 (95% CI=0.75-0.81), and 0.66 (95% CI=0.61-0.71) vs. 0.64 (95% CI=0.59-0.69), for polytomous and dichotomous regression models, respectively.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Data Interpretation, Statistical. Humans. Male. Neoplasm, Residual. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / secondary. Teratoma / diagnosis. Teratoma / drug therapy. Teratoma / secondary. Testicular Neoplasms / drug therapy

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  • (PMID = 18177785.001).
  • [ISSN] 0895-4356
  • [Journal-full-title] Journal of clinical epidemiology
  • [ISO-abbreviation] J Clin Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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82. Venizelos ID, Tatsiou ZA, Roussos D, Karagiannis V: A case of sebaceous carcinoma arising within a benign ovarian cystic teratoma. Onkologie; 2009 Jun;32(6):353-5
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  • [Title] A case of sebaceous carcinoma arising within a benign ovarian cystic teratoma.
  • BACKGROUND: Mature cystic teratoma, also known as dermoid cyst, is the most common germ cell tumor of the ovary.
  • Malignant change in a component of a mature ovarian teratoma is rare, occurring in less than 2% of cases, with squamous cell carcinoma corresponding to 80% of such neoplasms.
  • Abdominal and pelvic ultrasound as well as computed tomography demonstrated a heterogenic tumor of the right ovary.
  • Histological examination of the tumor showed features of a well-differentiated sebaceous carcinoma arising within a mature cystic teratoma.

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19521124.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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83. Mitra A, Jameson C, Barbachano Y, Sanchez L, Kote-Jarai Z, Peock S, Sodha N, Bancroft E, Fletcher A, Cooper C, Easton D, IMPACT Steering Committee and IMPACT and EMBRACE Collaborators, Eeles R, Foster CS: Overexpression of RAD51 occurs in aggressive prostatic cancer. Histopathology; 2009 Dec;55(6):696-704
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  • RAD51 protein expression in the cytoplasm and nuclei of the benign tissues was significantly less than in the malignant tissues (P < 0.001).
  • In all cancers, cytoplasmic expression of RAD51 was more prevalent and associated with higher Gleason score (P < 0.05) irrespective of BRCA mutational status, than its expression in benign tissues (P < 0.001).
  • Although nuclear immunoreactivity was not observed in BRCA-associated cancers with Gleason score < or =7, it was significantly increased in all other groups of prostatic cancers when compared with benign tissues (P < 0.001).
  • CONCLUSIONS: RAD51 protein is strongly expressed in high-grade prostatic cancers, whether sporadic or associated with BRCA germ-line mutations.
  • [MeSH-major] BRCA1 Protein / genetics. BRCA2 Protein / genetics. Germ-Line Mutation / genetics. Prostatic Neoplasms / metabolism. Rad51 Recombinase / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Cell Count. Gene Expression Regulation, Neoplastic. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Severity of Illness Index

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  • [Cites] Pathologe. 1987 May;8(3):138-40 [3303008.001]
  • [Cites] Mol Cell Biol. 2004 Nov;24(21):9305-16 [15485900.001]
  • [Cites] Nat Genet. 2009 Oct;41(10):1058-60 [19767752.001]
  • [Cites] Nat Genet. 2009 Oct;41(10):1116-21 [19767753.001]
  • [Cites] Br J Cancer. 2009 Oct 20;101(8):1469-80 [19826428.001]
  • [Cites] Nat Rev Cancer. 2009 Nov;9(11):821-9 [19776747.001]
  • [Cites] J Biol Chem. 2009 Nov 13;284(46):31945-52 [19783859.001]
  • [Cites] J Natl Cancer Inst. 1997 Jan 1;89(1):66-71 [8978408.001]
  • [Cites] Cell. 1997 Jan 24;88(2):265-75 [9008167.001]
  • [Cites] Cell. 1997 Aug 8;90(3):425-35 [9267023.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12075-80 [9342365.001]
  • [Cites] J Natl Cancer Inst. 1999 Aug 4;91(15):1310-6 [10433620.001]
  • [Cites] Cancer Res. 1999 Aug 1;59(15):3547-51 [10446958.001]
  • [Cites] Nat Cell Biol. 2005 Feb;7(2):195-201 [15665856.001]
  • [Cites] J Biol Chem. 2005 Mar 4;280(9):8051-9 [15611070.001]
  • [Cites] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078.001]
  • [Cites] Br J Cancer. 2005 Jul 11;93(1):137-43 [15956972.001]
  • [Cites] Br J Cancer. 2005 Aug 22;93(4):478-82 [16091762.001]
  • [Cites] Nat Struct Mol Biol. 2005 Oct;12(10):902-9 [16186822.001]
  • [Cites] J Clin Oncol. 2005 Oct 20;23(30):7503-11 [16234517.001]
  • [Cites] J Cell Biochem. 2005 Dec 15;96(6):1095-109 [16215984.001]
  • [Cites] Hum Mutat. 2006 Jan;27(1):14-20 [16278824.001]
  • [Cites] Eur J Gynaecol Oncol. 2005;26(6):589-98 [16398215.001]
  • [Cites] J Cell Biochem. 2006 Feb 15;97(3):433-47 [16267836.001]
  • [Cites] Int J Oncol. 2006 May;28(5):1113-9 [16596227.001]
  • [Cites] J Natl Cancer Inst. 2007 Jun 20;99(12):929-35 [17565157.001]
  • [Cites] BJU Int. 2007 Dec;100(6):1240-4 [17979924.001]
  • [Cites] Br J Cancer. 2008 Jan 29;98(2):502-7 [18182994.001]
  • [Cites] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387.001]
  • [Cites] Br J Cancer. 2008 Apr 22;98(8):1457-66 [18349832.001]
  • [Cites] Hum Mol Genet. 2008 Oct 15;17(R2):R109-15 [18852198.001]
  • [Cites] BJU Int. 2009 Jul;104(1):20-4 [19239456.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2460-7 [19723918.001]
  • [Cites] Oncogene. 2000 May 25;19(23):2791-5 [10851081.001]
  • [Cites] Int J Cancer. 2000 Dec 15;88(6):907-13 [11093813.001]
  • [Cites] Oncogene. 2002 Jul 25;21(32):5002-5 [12118380.001]
  • [Cites] J Natl Cancer Inst. 2002 Sep 18;94(18):1358-65 [12237281.001]
  • [Cites] Am J Hum Genet. 2003 Jan;72(1):1-12 [12474142.001]
  • [Cites] Oncogene. 2003 Feb 27;22(8):1115-23 [12606939.001]
  • [Cites] Exp Cell Res. 2003 Jun 10;286(2):298-307 [12749858.001]
  • [Cites] Oncogene. 2004 Jan 15;23(2):546-53 [14724582.001]
  • [Cites] J Mol Biol. 2004 Jun 11;339(4):797-804 [15165851.001]
  • [Cites] J Pathol. 1994 Aug;173(4):371-9 [7965396.001]
  • (PMID = 20002770.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / 10118; United Kingdom / Cancer Research UK / / A3354; United Kingdom / Cancer Research UK / / C5047/A8385
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BRCA1 Protein; 0 / BRCA2 Protein; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 2.7.7.- / RAD51 protein, human; EC 2.7.7.- / Rad51 Recombinase
  • [Other-IDs] NLM/ PMC2856636; NLM/ UKMS28917
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84. Riethdorf S, Reimers N, Assmann V, Kornfeld JW, Terracciano L, Sauter G, Pantel K: High incidence of EMMPRIN expression in human tumors. Int J Cancer; 2006 Oct 15;119(8):1800-10
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  • Extracellular matrix metalloproteinase inducer expressed by tumor cells stimulates peritumoral fibroblasts to produce matrix metalloproteinases, thus contributing to tumor invasion and metastasis.
  • EMMPRIN expression was detected immunohistochemically using monoclonal antibodies MEM-M6/1 and HIM6 and tissue microarrays with 2,348 and 608 tissue samples from 129 distinct tumor types and 76 different normal tissues, respectively.
  • EMMPRIN expression was found in 112 of 129 tumor entities analyzed with malignant tumors being EMMPRIN positive more frequently than benign tumors.
  • A remarkable heterogeneity in EMMPRIN expression between tumor entities was observed.
  • Among others, squamous-cell carcinomas (60-100%), pancreatic (87%), chromophobic kidney (83%), hepatocellular (83%) or medullary breast (83%) adenocarcinomas as well as glioblastoma multiforme (79%) presented with a particular high incidence of EMMPRIN expression.
  • There were a limited number of EMMPRIN-positive normal cell types including proliferatively active and differentiating epithelial cells, germ cells, myocardial cells in the left heart ventricle or vascular endothelial cells of the brain.
  • [MeSH-minor] Carbohydrate Metabolism. Cell Line, Tumor. Female. Humans. Immunohistochemistry. Male. Protein Isoforms / metabolism

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16721788.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Isoforms; 136894-56-9 / Antigens, CD147
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85. Treiyer A, Blanc G, Stark E, Haben B, Treiyer E, Steffens J: Prepubertal testicular tumors: frequently overlooked. J Pediatr Urol; 2007 Dec;3(6):480-3
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  • RESULTS: Of 15 primary testicular tumors, eight (53%) were germ-cell tumors (three teratomas, two yolk sac tumors, one seminoma, one embryonic carcinoma and one choriocarcinoma), four (27%) tumor-like lesions (epidermoid cysts), two (13%) gonadal stromal tumors (a Leydig and a Sertoli cell tumor), and one (7%) gonadoblastoma with gonadal dysgenesis.
  • All boys were presented with a painless scrotal mass and four (27%) of them with elevated tumor markers.
  • At a mean 4-year follow-up no patient has presented with recurrent tumor in the residual or contralateral testicle.
  • Postoperative physical examination and scrotal ultrasound were obtained in 14 patients at a median follow-up of 48.2 months, and there was no evidence of tumor progression.
  • CONCLUSIONS: Benign teratoma and epidermoid cysts were the most common prepubertal testicular tumors.
  • Any suspicion of a testicular tumor warrants an inguinal approach to prevent scrotal violation of the tumor.
  • Our limited experience with testis-sparing procedures supports the current trends that organ-confined surgery should be performed for benign lesions such as teratoma, Leydig cell tumor and epidermoid cysts based on frozen biopsy findings.

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  • (PMID = 18947799.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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86. Leiserowitz GS: Managing ovarian masses during pregnancy. Obstet Gynecol Surv; 2006 Jul;61(7):463-70
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  • The etiologies of ovarian masses are reflective of the patient's age; and, therefore, benign entities such as functional ovarian cysts, benign cystic teratomas, and serous cystadenomas predominate.
  • In the unusual cases when cancer is present, they are typically germ cell and borderline ovarian tumors, and are commonly low stage and low grade.
  • Morphologic criteria more accurately identify benign cysts compared with malignant tumors.
  • Tumor markers are used primarily to monitor disease status after treatment rather than establish the ovarian tumor diagnosis as a result of lack of specificity, because several markers can be elevated inherent to the pregnancy itself (eg, CA-125, beta-hCG).
  • The extent of surgery depends on the intraoperative diagnosis of a benign versus a malignant tumor.
  • Conservative surgery is appropriate for benign masses and borderline ovarian tumors.
  • [MeSH-minor] Female. Humans. Laparoscopy / methods. Neoplasm Staging. Pregnancy. Pregnancy Outcome. Prognosis. Risk Factors. Sensitivity and Specificity


87. Bandarchi B, Ma L, Marginean C, Hafezi S, Zubovits J, Rasty G: D2-40, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans. Mod Pathol; 2010 Mar;23(3):434-8
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  • D2-40 identifies a 40-kDa O-linked sialoglycoprotein present on a variety of tissues including testicular germ cell tumors as well as lymphatic endothelium.
  • [MeSH-major] Antibodies, Monoclonal / analysis. Biomarkers, Tumor / analysis. Dermatofibrosarcoma / diagnosis. Histiocytoma, Benign Fibrous / diagnosis

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  • (PMID = 20062007.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40; EC 2.3.2.13 / Factor XIIIa
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88. Tellechea O, Reis JP: Trichogerminoma. Am J Dermatopathol; 2009 Jul;31(5):480-3
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  • A case of distinctive benign follicular neoplasm previously reported under the designation of trichogerminoma is described.
  • The lesion had the characteristics of hair germ tumors; however, most lobules depicted a distinctive pattern of rounded nests of concentrically arranged clear cells.
  • This neoplasm and the other tumors with hair germ differentiation such as trichoblastoma and panfolliculoma seem to represent the same spectrum of hair follicle neoplasms only distinguishable by their degree of differentiation.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 19542926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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89. Kempkensteffen C, Hinz S, Krause H, Jager T, Köllermann J, Weikert S, Christoph F, Schostak M, Miller K, Schrader M: Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors. Tumour Biol; 2008;29(2):76-82
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  • [Title] Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors.
  • The inhibitor of apoptosis family member livin is expressed in several neoplasms but is absent in most benign tissues.
  • Livin has therefore been evaluated as a diagnostic and prognostic marker and recently gained much attention as a target for tumor therapy.
  • We evaluated the expression of livin splicing variants in 131 testicular germ cell tumors (TGCT) compared to 20 normal testicular tissue samples using dual-color real-time RT-PCR and Western blot analysis.
  • Livin expression was strongly related to TGCT differentiation but not to clinical tumor stage and patient age.
  • The beta-variant was expressed in 67.5% of seminomas but only in 27.1% of nonseminomatous germ cell tumors (NSGCT).
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Apoptosis / physiology. Gene Expression Regulation, Neoplastic / physiology. Inhibitor of Apoptosis Proteins / genetics. Neoplasm Proteins / genetics. Neoplasms, Germ Cell and Embryonal / genetics. Protein Splicing / genetics. Testicular Neoplasms / genetics

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18515985.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BIRC7 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Neoplasm Proteins; 0 / Protein Isoforms
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90. Blum B, Benvenisty N: The tumorigenicity of human embryonic stem cells. Adv Cancer Res; 2008;100:133-58
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  • Human embryonic stem cells (HESCs) are the in vitro descendants of the pluripotent inner cell mass (ICM) of human blastocyst stage embryos.
  • HESCs can be kept undifferentiated in culture or be differentiated to tissues representing all three germ layers, both in vivo and in vitro.
  • These are benign masses of haphazardly differentiated tissues.
  • We thus conclude with a survey of approaches to evade HESC-induced tumor formation.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Embryonic Stem Cells / physiology. Teratocarcinoma / etiology
  • [MeSH-minor] Adaptation, Biological / physiology. Animals. Cell Culture Techniques. Cell Differentiation / physiology. Embryonic Development / genetics. Embryonic Development / physiology. Genetic Diseases, Inborn / pathology. Humans. Models, Biological. Teratoma / etiology

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  • (PMID = 18620095.001).
  • [ISSN] 0065-230X
  • [Journal-full-title] Advances in cancer research
  • [ISO-abbreviation] Adv. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 128
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91. Thomas L, Kluwe L, Chuzhanova N, Mautner V, Upadhyaya M: Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden. Neurogenetics; 2010 Oct;11(4):391-400
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  • [Title] Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden.
  • Neurofibromatosis type 1, (NF1) is a complex, autosomal dominant disorder characterized by benign and malignant tumors which result from NF1 gene mutations.
  • These modifying loci may include deficiencies in mismatch repair genes and elements involved in cell cycle regulation (TP53, RB1, and CDKN2A).
  • We have analyzed the somatic mutations in 89 cutaneous neurofibromas derived from three unrelated NF1 patients with high tumor burden, by loss of heterozygosity (LOH) analysis of the NF1, TP53, RB1, and CDKN2A genes, by assessing microsatellite instability (MSI), by direct sequencing of the NF1, TP53, and several mismatch repair (MMR) genes and by multiplex ligation-dependent probe amplification of the NF1 and TP53 genes.
  • Each mutation was distinct demonstrating the independent origin of each tumor.
  • LOH of markers flanking the RB1 gene was also found in one tumor but no CDKN2A mutations were detected.
  • The identification of LOH involving TP53 and RB1 loci is a novel finding in benign cutaneous neurofibromas possibly demonstrating an alternative underlying molecular mechanism associated with the development of these benign tumors from this cohort of patients.
  • [MeSH-minor] Adult. Computational Biology / methods. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Mutational Analysis. Female. Genes, p53. Germ-Line Mutation. Humans. Loss of Heterozygosity. Male. Middle Aged. Retinoblastoma Protein / genetics

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  • [Cites] Nature. 1998 May 21;393(6682):229-34 [9607760.001]
  • [Cites] Hum Genet. 2008 Sep;124(2):105-22 [18709565.001]
  • [Cites] Electrophoresis. 2008 Dec;29(23):4627-36 [19053154.001]
  • [Cites] Am J Pathol. 1999 Dec;155(6):1879-84 [10595918.001]
  • [Cites] Genes Chromosomes Cancer. 2006 Oct;45(10):893-904 [16830335.001]
  • [Cites] Hum Genet. 2003 Feb;112(2):117-23 [12522551.001]
  • [Cites] Hum Mutat. 2004 Feb;23(2):177-85 [14722921.001]
  • [Cites] Clin Cancer Res. 2008 Feb 15;14(4):1015-24 [18281533.001]
  • [Cites] Cell Stem Cell. 2009 May 8;4(5):453-63 [19427294.001]
  • [Cites] Cancer Res. 2005 Oct 1;65(19):8662-70 [16204034.001]
  • [Cites] Cancer Res. 2001 Feb 1;61(3):1154-61 [11221846.001]
  • [Cites] Virchows Arch. 2002 Jun;440(6):610-5 [12070601.001]
  • [Cites] Nat Genet. 2001 Jul;28(3):294-6 [11431704.001]
  • [Cites] Hum Mutat. 2004 Feb;23(2):134-46 [14722917.001]
  • [Cites] Hum Mutat. 2006 Oct;27(10 ):1030-40 [16941471.001]
  • [Cites] Cancer Res. 1995 Dec 1;55(23):5677-80 [7585653.001]
  • [Cites] Trends Cell Biol. 2009 Aug;19(8):395-403 [19615906.001]
  • [Cites] Am J Hum Genet. 1997 Sep;61(3):512-9 [9326316.001]
  • [Cites] J Med Genet. 2007 Feb;44(2):81-8 [17105749.001]
  • [Cites] Cancer Genet Cytogenet. 2005 Mar;157(2):181-6 [15721644.001]
  • [Cites] Am J Med Genet A. 2008 Jun 1;146A(11):1444-52 [18438896.001]
  • [Cites] Nucleic Acids Res. 1991 Dec 25;19(24):6977 [1762941.001]
  • [Cites] J Vis Exp. 2007;(8):309 [18989416.001]
  • [Cites] Nat Genet. 1995 Oct;11(2):210-2 [7550353.001]
  • [Cites] Nucleic Acids Res. 1991 Sep 11;19(17):4796 [1716362.001]
  • [Cites] Biochem Biophys Res Commun. 1997 May 19;234(2):346-50 [9177273.001]
  • [Cites] Curr Opin Neurol. 2004 Apr;17(2):101-5 [15021234.001]
  • [Cites] Hum Mutat. 2005 Sep;26(3):205-13 [16086312.001]
  • [Cites] Biochim Biophys Acta. 2000 Jul 31;1471(1):M13-9 [10967421.001]
  • [Cites] Genes Chromosomes Cancer. 1994 Aug;10(4):250-5 [7522538.001]
  • [Cites] Genes Chromosomes Cancer. 2007 Sep;46(9):820-7 [17563086.001]
  • [Cites] Science. 1999 Dec 10;286(5447):2172-6 [10591652.001]
  • [Cites] Hum Mutat. 2003 Sep;22(3):229-44 [12938088.001]
  • [Cites] Hum Mutat. 2008 Aug;29(8):E103-11 [18484666.001]
  • [Cites] Cell. 2001 Feb 23;104(4):593-604 [11239415.001]
  • [Cites] Am J Hum Genet. 1989 Oct;45(4):547-55 [2577468.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14162-7 [15377784.001]
  • [Cites] Hum Genet. 2000 Jul;107(1):33-9 [10982032.001]
  • [Cites] Fam Cancer. 2007;6(4):463-71 [17551851.001]
  • [Cites] J Med Genet. 2000 Jan;37(1):44-9 [10633134.001]
  • [Cites] Science. 1999 Dec 10;286(5447):2176-9 [10591653.001]
  • [Cites] Mol Cell Probes. 1999 Apr;13(2):157-65 [10208807.001]
  • [Cites] Lab Invest. 2000 May;80(5):709-18 [10830781.001]
  • [Cites] Glia. 2008 Nov 1;56(14):1590-605 [18803326.001]
  • [Cites] Am J Pathol. 1999 Dec;155(6):1855-60 [10595915.001]
  • [Cites] Bioinformatics. 1999 Dec;15(12):994-9 [10745989.001]
  • [Cites] Eur J Hum Genet. 2000 Dec;8(12):939-45 [11175282.001]
  • [Cites] Cancer Res. 1996 Aug 15;56(16):3842-9 [8706033.001]
  • [Cites] Cancer Res. 2008 Jul 1;68(13):5059-66 [18593904.001]
  • [Cites] Neurosurgery. 2006 Jan;58(1):1-16; discussion 1-16 [16385324.001]
  • [Cites] Diagn Mol Pathol. 1996 Sep;5(3):214-9 [8866236.001]
  • [Cites] Hum Mutat. 2003 Jan;21(1):28-44 [12497629.001]
  • (PMID = 20358387.001).
  • [ISSN] 1364-6753
  • [Journal-full-title] Neurogenetics
  • [ISO-abbreviation] Neurogenetics
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein
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92. Connolly SS, D'Arcy FT, Bredin HC, Callaghan J, Corcoran MO: Value of frozen section analysis with suspected testicular malignancy. Urology; 2006 Jan;67(1):162-5
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  • The exclusion criteria included lesions of paratesticular origin, size greater than 5 cm, and the known presence of elevated tumor markers or metastatic disease.
  • RESULTS: Eighty men underwent FSA, facilitating the diagnosis of germ cell malignancy in 51 (54.3%) of the 94 new cases encountered during this period.
  • Malignancy was reported by FSA in 52 patients (65.0%), but was later revised in 3 to benign Leydig cell tumor after orchiectomy.
  • Also, 2 of 27 specimens reported as benign by FSA were revised to malignant after analysis of paraffin-embedded tissue from the biopsies.
  • FSA was reported as "suspicious" (intratubular germ cell neoplasia with necrosis) in 1 patient, in whom orchiectomy was performed and malignancy confirmed.
  • Of 13 lesions 1 cm or less, 10 (76.9%) were benign.

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  • (PMID = 16413354.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Saito M, Yuasa T, Nanjo H, Tsuchiya N, Satoh S, Habuchi T: A case of testicular angiomyolipoma. Int J Urol; 2008 Feb;15(2):185-7
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  • The majority of testicular tumors are germ cell tumors, which are the most prevalent solid malignancies in young adult males.
  • Non-germ cell tumors of the testis are rare.
  • A 22-year-old male underwent left orchiectomy under a diagnosis of testicular tumor.
  • The tumor demonstrated neither cytological atypia nor widespread mitotic activity.
  • In addition, the tumor cells showed intense expression of CD34 and smooth muscle actin, whereas HMB-45 was entirely negative.
  • Although the true cellular origin and its clinical implications remain unknown, pathological and immunohistochemical studies strongly indicated benign testicular AML with a non-germ cell origin.

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  • (PMID = 18269463.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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94. Yu DK, Joo YH, Cho KH: Trichoblastoma with apocrine and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):6-8
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  • Trichoblastoma is a rare, benign tumor that differentiates toward the hair germ, the embryonic precursor of a hair follicle.
  • An immunohistochemical study showed that the neoplasm, or areas in it, stained positive for low molecular cytokeratin, high molecular cytokeratin, EMA, S-100, and GCDFP-15.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic. Female. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome

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  • (PMID = 15677969.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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95. Kaur H, Bagga R, Saha SC, Gainder S, Srinivasan R, Adhya AK, Dhaliwal LK: Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. Int J Clin Oncol; 2009 Feb;14(1):78-81
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  • [Title] Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites.
  • Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade.
  • Being solid tumors, they may be associated with ascites and pleural effusion (Meigs' syndrome), which resolve after surgical removal of the tumor.
  • Tumor markers for GCT are still investigational (inhibin) and of not much use in making a preoperative diagnosis, unlike in the case of germ cell tumors.
  • In the present patient, because of the association of Meigs' syndrome, a preoperative diagnosis of benign tumors such as fibroma/thecoma was also considered.
  • We report this rare tumor with an aim of reviewing the diagnosis and management from the reported literature.
  • [MeSH-major] Ascites / etiology. Granulosa Cell Tumor / pathology. Meigs Syndrome / pathology. Ovarian Neoplasms / pathology. Pleural Effusion, Malignant / etiology

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  • [Cites] Singapore Med J. 2001 May;42(5):203-7 [11513057.001]
  • [Cites] Korean J Intern Med. 2005 Mar;20(1):105-9 [15906965.001]
  • [Cites] Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):323-7 [9988794.001]
  • [Cites] Obstet Gynecol. 1978 Dec;52(6):718-23 [733139.001]
  • [Cites] Gynecol Oncol. 1999 Apr;73(1):51-5 [10094880.001]
  • [Cites] Gynecol Oncol. 1995 Dec;59(3):405-8 [8522265.001]
  • [Cites] Gynecol Oncol. 2007 Feb;104(2):396-400 [17030354.001]
  • [Cites] Cancer. 1997 May 15;79(10):1951-5 [9149022.001]
  • [Cites] Gynecol Oncol. 2005 Jan;96(1):204-9 [15589602.001]
  • [Cites] Gynecol Oncol. 1999 Apr;73(1):35-41 [10094877.001]
  • [Cites] Am J Obstet Gynecol. 2004 Jul;191(1):366-7 [15295395.001]
  • [Cites] Gynecol Oncol. 1996 Mar;60(3):484-8 [8774662.001]
  • [Cites] N Engl J Med. 1989 Sep 21;321(12):790-3 [2770810.001]
  • [Cites] Gynecol Oncol. 1995 Mar;56(3):338-44 [7705666.001]
  • [Cites] Gynecol Oncol. 2006 Oct;103(1):31-4 [16537089.001]
  • (PMID = 19225930.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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96. Waldmann J, Bartsch DK, Kann PH, Fendrich V, Rothmund M, Langer P: Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening. Langenbecks Arch Surg; 2007 Jul;392(4):437-43
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  • Age at diagnosis of MEN-1, type of adrenal tumor, genotype, therapy, and clinical characteristics have been analyzed.
  • Median tumor size was 12 mm (5-40 mm).
  • Tumor size smaller than 10 mm was observed in 11 patients.
  • CONCLUSION: MEN-1-associated adrenal tumors are mostly small, benign, and nonfunctioning and much more common than previously reported.
  • [MeSH-minor] Adolescent. Adrenalectomy. Adult. Aged. DNA Mutational Analysis. Endosonography. Female. Genotype. Germ-Line Mutation. Humans. Male. Middle Aged. Phenotype. Prevalence. Prospective Studies

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  • [Cites] Acta Med Scand. 1968 Sep;184(3):211-4 [5703975.001]
  • [Cites] Endocr Pract. 2000 Jan-Feb;6(1):13-9 [11419921.001]
  • [Cites] Int J Cancer. 1999 Jan 29;80(3):373-9 [9935177.001]
  • [Cites] Arch Intern Med (Chic). 1948 Jan;81(1):37-41 [18899021.001]
  • [Cites] NIH Consens State Sci Statements. 2002 Feb 4-6;19(2):1-25 [14768652.001]
  • [Cites] Crit Rev Oncol Hematol. 1984;2(2):117-84 [6152202.001]
  • [Cites] World J Surg. 1996 Sep;20(7):872-6; discussion 877 [8678965.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Sep;86(9):4371-4 [11549677.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Dec;86(12):5658-71 [11739416.001]
  • [Cites] Cancer Genet Cytogenet. 1992 Oct 1;63(1):17-21 [1358429.001]
  • [Cites] Arch Dermatol. 1997 Jul;133(7):853-7 [9236523.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Mar;88(3):1066-81 [12629087.001]
  • [Cites] World J Surg. 2002 Aug;26(8):891-6 [12016472.001]
  • [Cites] Arch Surg. 1996 Jul;131(7):699-702 [8678766.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23 [11158604.001]
  • [Cites] J Clin Endocrinol Metab. 1992 Jul;75(1):76-81 [1352309.001]
  • [Cites] Cancer Genet Cytogenet. 1995 Feb;79(2):123-6 [7889502.001]
  • [Cites] Medicine (Baltimore). 2004 Jan;83(1):43-83 [14747767.001]
  • [Cites] Science. 1997 Apr 18;276(5311):404-7 [9103196.001]
  • [Cites] Gastroenterology. 1999 Feb;116(2):286-93 [9922308.001]
  • [Cites] Surgery. 1998 Dec;124(6):1106-13; discussion 1113-4 [9854591.001]
  • [Cites] J Urol. 2001 Jul;166(1):24-7 [11435815.001]
  • [Cites] Gen Diagn Pathol. 1996 Mar;141(3-4):203-8 [8705784.001]
  • [Cites] Sem Hop. 1971 Feb 14;47(8):494-525 [4396157.001]
  • [Cites] Ann Intern Med. 1998 Sep 15;129(6):484-94 [9735087.001]
  • [Cites] J Pathol. 1969 Sep;99(1):1-18 [5359219.001]
  • [Cites] Med Klin (Munich). 1998 Sep 15;93(9):546-9 [9792021.001]
  • [Cites] Eur J Endocrinol. 2000 Jun;142(6):689-95 [10822234.001]
  • [Cites] Cell. 1999 Jan 8;96(1):143-52 [9989505.001]
  • [Cites] Oncogene. 1999 Oct 21;18(43):5936-42 [10557080.001]
  • [Cites] Hum Genet. 1999 Dec;105(6):603-10 [10647896.001]
  • [Cites] Can Med Assoc J. 1970 Jul 4;103(1):34-6 [5424294.001]
  • [Cites] J Intern Med. 1998 Jun;243(6):465-70 [9681844.001]
  • [Cites] World J Surg. 1997 Jan;21(1):36-40 [8943175.001]
  • [Cites] Endocrinol Metab Clin North Am. 2000 Sep;29(3):541-67 [11033760.001]
  • [Cites] Endocr Rev. 1987 Nov;8(4):391-405 [2891500.001]
  • [Cites] Curr Opin Oncol. 2003 Jan;15(1):84-90 [12490767.001]
  • [Cites] Oncogene. 2001 Aug 16;20(36):4917-25 [11526476.001]
  • [Cites] Lancet. 1967 Mar 4;1(7488):468-70 [4164067.001]
  • [Cites] QJM. 1996 Sep;89(9):653-69 [8917740.001]
  • [Cites] Am J Med. 1954 Mar;16(3):363-71 [13138607.001]
  • [Cites] Surgery. 1995 Dec;118(6):1077-82 [7491526.001]
  • [Cites] Medicine (Baltimore). 1964 Jul;43:481-516 [14183520.001]
  • [Cites] Surgery. 2000 Dec;128(6):958-66 [11114630.001]
  • [Cites] J Clin Endocrinol Metab. 1999 Jan;84(1):216-9 [9920087.001]
  • [Cites] Am J Surg. 1987 Jul;154(1):142-8 [2886072.001]
  • (PMID = 17235589.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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97. Tinelli A, Vergara D, Martignago R, Leo G, Pisanò M, Malvasi A: An outlook on ovarian cancer and borderline ovarian tumors: focus on genomic and proteomic findings. Curr Genomics; 2009 Jun;10(4):240-9
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  • Ovarian tumors can be classified on the basis of the cells of origin in epithelial, stromal and germ cell tumors.
  • Epithelial ovarian tumors display great histological heterogeneity and can be further subdivided into benign, intermediate or borderline, and invasive tumors.
  • In this review, the current state of knowledge about the genoproteomic and potential clinical value of gene expression profiling in ovarian cancer and ovarian borderline tumors is discussed, focusing on three main areas: distinguishing normal ovarian tissue from ovarian cancers and borderline tumors, identifying different genotypes of ovarian tissue and identifying proteins linked to cancer or tumor development.
  • By these targets, authors focus on the use of novel molecules, developed on the proteomics and genomics researches, as potential protein biomarkers in the management of ovarian cancer or borderline tumor, overlooking on current state of the art and on future perspectives of researches.

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  • [Cites] Br J Cancer. 2001 Dec 14;85(12):1922-7 [11747335.001]
  • [Cites] Ann Epidemiol. 2001 Nov;11(8):568-74 [11709277.001]
  • [Cites] Oncogene. 2001 Oct 4;20(45):6503-15 [11641774.001]
  • [Cites] Tumour Biol. 2001 Sep-Oct;22(5):282-5 [11553857.001]
  • [Cites] J Natl Cancer Inst. 2001 Jul 18;93(14):1054-61 [11459866.001]
  • [Cites] J Biol Chem. 2001 Jul 20;276(29):27371-5 [11369781.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8018-23 [11416160.001]
  • [Cites] Anticancer Res. 2000 Nov-Dec;20(6D):4965-8 [11326648.001]
  • [Cites] Oncogene. 2009 Mar 5;28(9):1206-17 [19151754.001]
  • [Cites] Gynecol Oncol. 2009 Mar;112(3):475-80 [19150122.001]
  • [Cites] Int J Biochem Cell Biol. 2009 May;41(5):1034-45 [18930836.001]
  • [Cites] Br J Cancer. 2009 Jan 13;100(1):134-44 [19088723.001]
  • [Cites] Acta Obstet Gynecol Scand. 2008;87(12):1353-60 [18951210.001]
  • [Cites] Biochem Pharmacol. 2008 Sep 15;76(6):707-16 [18644348.001]
  • [Cites] Endocrinology. 2008 Aug;149(8):3809-16 [18450971.001]
  • [Cites] FEBS Lett. 2008 Jun 18;582(14):2102-11 [18396168.001]
  • [Cites] Histol Histopathol. 2008 Aug;23(8):935-44 [18498068.001]
  • [Cites] Mol Cancer Res. 2008 May;6(5):695-705 [18505915.001]
  • [Cites] J Proteome Res. 2007 Nov;6(11):4127-34 [17939699.001]
  • [Cites] Micron. 2007;38(8):824-33 [17709250.001]
  • [Cites] Mol Carcinog. 2007 Aug;46(8):725-31 [17610223.001]
  • [Cites] J Proteome Res. 2007 Jul;6(7):2509-17 [17547437.001]
  • [Cites] Mol Cancer Ther. 2007 Jul;6(7):1993-2002 [17620429.001]
  • [Cites] Cancer. 2007 May 1;109(9):1887-96 [17373668.001]
  • [Cites] Ann Oncol. 2007 May;18(5):881-5 [17301071.001]
  • [Cites] Int J Gynecol Pathol. 2007 Jan;26(1):10-5 [17197890.001]
  • [Cites] Gynecol Oncol. 2006 Dec;103(3):924-31 [16842844.001]
  • [Cites] Cancer. 2006 Dec 1;107(11):2730-40 [17063503.001]
  • [Cites] J Natl Cancer Inst. 2006 Nov 1;98(21):1558-70 [17077358.001]
  • [Cites] Cancer. 2006 Oct 1;107(7):1511-9 [16944535.001]
  • [Cites] Cancer Res. 2006 Sep 15;66(18):9017-25 [16982743.001]
  • [Cites] Cancer. 2006 Sep 15;107(6):1407-18 [16902988.001]
  • [Cites] Clin Obstet Gynecol. 2006 Sep;49(3):433-47 [16885651.001]
  • [Cites] EMBO Rep. 2006 Jun;7(6):599-604 [16741504.001]
  • [Cites] Eur J Gynaecol Oncol. 2006;27(2):171-6 [16620064.001]
  • [Cites] Clin Cancer Res. 2006 Mar 15;12(6):1707-14 [16551853.001]
  • [Cites] Ann Intern Med. 2006 Mar 21;144(6):397-406 [16549852.001]
  • [Cites] Clin Cancer Res. 2006 Mar 1;12(5):1487-93 [16533772.001]
  • [Cites] Nat Rev Cancer. 2006 Mar;6(3):227-39 [16498445.001]
  • [Cites] Pathol Int. 2006 Feb;56(2):62-70 [16445817.001]
  • [Cites] Clin Cancer Res. 2006 Jan 15;12(2):447-53 [16428485.001]
  • [Cites] J Clin Oncol. 2005 Dec 20;23(36):9338-43 [16361633.001]
  • [Cites] Int J Gynecol Cancer. 2005 Nov-Dec;15 Suppl 3:274-81 [16343244.001]
  • [Cites] Nat Rev Cancer. 2005 Nov;5(11):845-56 [16239904.001]
  • [Cites] Am J Obstet Gynecol. 2005 Nov;193(5):1630-9 [16260202.001]
  • [Cites] Cancer Res. 2005 Oct 15;65(20):9415-25 [16230405.001]
  • [Cites] Mol Endocrinol. 2005 Oct;19(10):2564-78 [15928314.001]
  • [Cites] Oncogene. 2005 Aug 29;24(37):5764-74 [16123809.001]
  • [Cites] Int J Gynecol Cancer. 2005 Jul-Aug;15(4):618-23 [16014115.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 May 24;102(21):7677-82 [15890779.001]
  • [Cites] Br J Cancer. 2005 May 9;92(9):1729-36 [15841084.001]
  • [Cites] Eur J Cancer. 2005 Feb;41(3):461-9 [15691647.001]
  • [Cites] Nat Rev Cancer. 2004 Nov;4(11):876-90 [15516960.001]
  • [Cites] Nat Med. 1999 Aug;5(8):938-42 [10426319.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 May 25;96(11):6249-54 [10339573.001]
  • [Cites] Anticancer Res. 1999 Jan-Feb;19(1B):849-51 [10216504.001]
  • [Cites] Clin Chem. 1999 May;45(5):651-8 [10222351.001]
  • [Cites] Anal Chem. 1997 Dec 1;69(23):4751-60 [9406525.001]
  • [Cites] Hum Pathol. 1997 Aug;28(8):922-8 [9269828.001]
  • [Cites] Genomics. 1997 Mar 1;40(2):371-4 [9119409.001]
  • [Cites] Mol Cell Biol. 1990 Dec;10(12):6316-24 [2174105.001]
  • [Cites] Proc Natl Acad Sci U S A. 1987 Sep;84(18):6379-83 [2819873.001]
  • [Cites] Clin Cancer Res. 2004 Aug 1;10(15):5145-50 [15297418.001]
  • [Cites] Oncol Rep. 2004 Jun;11(6):1153-9 [15138549.001]
  • [Cites] Endocr Relat Cancer. 2004 Mar;11(1):35-49 [15027884.001]
  • [Cites] Annu Rev Immunol. 2004;22:329-60 [15032581.001]
  • [Cites] Gynecol Oncol. 2004 Mar;92(3):761-8 [14984938.001]
  • [Cites] Cancer Cell. 2004 Jan;5(1):19-24 [14749123.001]
  • [Cites] Mol Cancer Ther. 2003 Oct;2(10):1067-78 [14578472.001]
  • [Cites] J Clin Pathol. 2003 Oct;56(10):764-8 [14514780.001]
  • [Cites] Exp Cell Res. 2003 Aug 15;288(2):382-9 [12915129.001]
  • [Cites] J Clin Oncol. 2003 May 15;21(10 Suppl):200s-205s [12743135.001]
  • [Cites] J Clin Oncol. 2003 May 15;21(10 Suppl):194s-199s [12743134.001]
  • [Cites] Physiol Rev. 2003 Apr;83(2):433-73 [12663865.001]
  • [Cites] Nature. 2002 Nov 7;420(6911):19 [12422186.001]
  • [Cites] Bioessays. 2002 Apr;24(4):350-61 [11948621.001]
  • [Cites] Curr Opin Genet Dev. 2001 Feb;11(1):41-7 [11163149.001]
  • [Cites] Clin Exp Metastasis. 2000;18(1):83-8 [11206843.001]
  • [Cites] Adv Cancer Res. 2000;77:81-137 [10549356.001]
  • [Cites] Eur J Gynaecol Oncol. 2007;28(2):103-8 [17479670.001]
  • [Cites] Eur J Gynaecol Oncol. 2007;28(2):83-8 [17479666.001]
  • [Cites] Int J Cancer. 2007 Jun 1;120(11):2426-34 [17294443.001]
  • [Cites] J Proteome Res. 2007 Apr;6(4):1440-50 [17315909.001]
  • [Cites] J Proteome Res. 2007 Apr;6(4):1295-305 [17291023.001]
  • [Cites] Am J Obstet Gynecol. 2007 Apr;196(4):348.e1-5 [17403417.001]
  • [Cites] Nat Rev Cancer. 2007 Feb;7(2):139-47 [17218951.001]
  • [Cites] Cancer Res. 2007 Feb 15;67(4):1670-9 [17308108.001]
  • [Cites] Trends Biotechnol. 2007 Mar;25(3):111-8 [17257698.001]
  • [Cites] J Proteome Res. 2007 Feb;6(2):772-80 [17269733.001]
  • [Cites] Anticancer Res. 2006 Nov-Dec;26(6C):4943-8 [17214367.001]
  • [Cites] Anticancer Res. 2006 Nov-Dec;26(6C):4721-8 [17214332.001]
  • [Cites] Cancer. 2007 Jan 15;109(2):332-40 [17154180.001]
  • [Cites] Nat Rev Cancer. 2002 Mar;2(3):161-74 [11990853.001]
  • [Cites] Biochim Biophys Acta. 2002 Mar 14;1602(1):47-59 [11960694.001]
  • [Cites] Br J Nutr. 2002 Jan;87 Suppl 1:S23-9 [11895152.001]
  • [Cites] Lancet. 2002 Feb 16;359(9306):572-7 [11867112.001]
  • [Cites] Proteomics. 2002 Jan;2(1):76-84 [11788994.001]
  • (PMID = 19949545.001).
  • [ISSN] 1875-5488
  • [Journal-full-title] Current genomics
  • [ISO-abbreviation] Curr. Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2709935
  • [Keywords] NOTNLM ; Ovarian cancer / borderline ovarian tumors / genomics / markers / oncogenes. / proteomics
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98. Ylisaukko-oja SK, Cybulski C, Lehtonen R, Kiuru M, Matyjasik J, Szymañska A, Szymañska-Pasternak J, Dyrskjot L, Butzow R, Orntoft TF, Launonen V, Lubiñski J, Aaltonen LA: Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma. Eur J Hum Genet; 2006 Jul;14(7):880-3
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  • Germline mutations in the fumarate hydratase (FH) gene were recently shown to predispose to the dominantly inherited syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC).
  • HLRCC is characterized by benign leiomyomas of the skin and the uterus, renal cell carcinoma, and uterine leiomyosarcoma.
  • The aim of this study was to identify new families with FH mutations, and to further examine the tumor spectrum associated with FH mutations.
  • These results suggest that benign ovarian tumors may be associated with HLRCC.
  • [MeSH-major] Cystadenoma, Mucinous / genetics. Fumarate Hydratase / genetics. Germ-Line Mutation. Neoplastic Syndromes, Hereditary / genetics. Ovarian Neoplasms / genetics
  • [MeSH-minor] Carcinoma, Renal Cell / genetics. Cystadenocarcinoma, Mucinous / genetics. Female. Genes, Dominant. Humans. Kidney Neoplasms / genetics. Leiomyoma / genetics. Male. Neoplasms / genetics. Skin Neoplasms / genetics. Urinary Bladder Neoplasms / genetics

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
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  • (PMID = 16639410.001).
  • [ISSN] 1018-4813
  • [Journal-full-title] European journal of human genetics : EJHG
  • [ISO-abbreviation] Eur. J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 4.2.1.2 / Fumarate Hydratase
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99. Tansel T, Onursal E, Dayloğlu E, Başaran M, Sungur Z, Qamci E, Yilmazbayhan D, Eker R, Ertuğrul T: Childhood mediastinal masses in infants and children. Turk J Pediatr; 2006 Jan-Mar;48(1):8-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There were 24 benign (64.8%) and 13 malignant (35.2%) tumors.
  • The cases were lymphoma (27%), neurogenic tumors (21.6%), cystic lesions (18.9%), germ cell tumors (13.5%), thymic lesions (10.8%) and cardiac tumors (8.1%).
  • Complete and partial resections of the tumor were the surgical procedures performed in 24 patients (64.8%) and 3 patients (8.1%), respectively.
  • The three patients with a malignant tumor, in whom the entire mass could not be removed, received chemotherapy and radiation after surgery.

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  • (PMID = 16562779.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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100. Wilson C, Idziaszczyk S, Parry L, Guy C, Griffiths DF, Lazda E, Bayne RA, Smith AJ, Sampson JR, Cheadle JP: A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Hum Mol Genet; 2005 Jul 1;14(13):1839-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma.
  • Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the TSC1 or the TSC2 genes and characterized by the development of benign hamartomatous growths in multiple organ systems.
  • We have inactivated Tsc1 in the mouse germ line by gene targeting in ES cells and confirmed that the mutant allele (Tsc1-) has a recessive embryonic lethal phenotype.
  • Eighty percent (16/20) of Tsc1+/- mice on a Balb/c background exhibited solid renal cell carcinomas (RCC) by 15-18 months and in 41%, RCCs were > or = 5 mm, resulting in grossly deformed kidneys.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Kidney Neoplasms / genetics. Tuberous Sclerosis / genetics. Tumor Suppressor Proteins / genetics






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